Cellular Defenses Against Radiation-Induced Carcinogenesis:

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Mutation spectrum matched UV mutagenesis and differs from mutations in internal tumors: NCI DE REB Brash <strong>Radiation</strong> Epidemiology et al. PNAS Course, May 88:10124, 14, 2007 1991 TJJ
For BCC, PTCH may be even a bigger target than p53 p53 PTCH J Dermatol Sci 29:1, 2002 NCI REB <strong>Radiation</strong> Epidemiology Course, May 14, 2007 TJJ
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Cellular Defenses Against Radiation
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GOALS: • Provide an overall descr
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NCI REB Radiation Epidemiology Cour
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Cancer cells “evolve” into a hi
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WHY CHECKPOINTS Fidelity of cell di
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Cyclin/CDK complexes seem to be reg
Page 19 and 20: • At least two checkpoints are re
Page 21 and 22: DO DEFECTIVE CHECKPOINTS CAUSE CANC
Page 23 and 24: Radiation-Induced G2 delay in lymph
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Page 31 and 32: Major DNA repair pathways: • Non-
Page 37 and 38: “… the failure of DNA repair in
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Page 41 and 42: NER PATHWAY GENES GENE ALIASES DESC
Page 43 and 44: Mismatch repair associated tumors i
Page 45 and 46: Non-Homologous End Joining (NHEJ) N
Page 47 and 48: Illegitimate Recombination NCI REB
Page 49 and 50: TARGET THEORY NCI REB Radiation Epi
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Page 53 and 54: OTHER TARGET QUESTIONS: • If DNA
Page 55 and 56: Mutations in Chk2 produce the Li-Fr
Page 57 and 58: CASE STUDY: Finding Molecular Targe
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