Tuesday, april 27 anatomy - Experimental Biology

Tuesday, April 27 

Anatomy 

822. Cell Biology and Cell Signaling 

Poster 

Tu e. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b it Ha l l CD 

Presentation time: 12:30 p m-2:00 p m 

C179 822.1 Substrate-dependent localization of 

transglutaminase 2. J. van den Akker, G.B. Afink, A. van 

Weert, J. de Vos, E.N.T.P. Bakker and E. vanBavel. Acad. 

Med. Ctr., Amsterdam. 

C180 822.2 Rab 11 is associated with Nectin 2 positive 

vesicles in Sertoli cells at newly forming adhesion junctions 

with early elongating spermatids in rat testis. J.S. Young and 

W. Vogl. Univ. of British Columbia. 

C181 822.3 Distribution patterns of soft and hard keratin 

proteins in finger nails, cat claws, and horse hooves. H.H. 

Bragulla, A.L. Foster, A.M. Stokes, M.J. Lopez and D.G. 

Homberger. LSU Sch. of Vet. Med. and LSU. 

C182 822.4 Role of caveolin-1 in the entry of HCMV into 

human extravillous trophoblast cells. L. Wang and L. Zhou. 

Sch. of Basic Med., Wuhan Univ., People’s Republic of China. 

C183 822.5 Eps15, but not AP-2, is recruited and essential 

for the formation of enteropathogenic E. coli pedestals. A.E. 

Lin, A. Benmerah and J.A. Guttman. Simon Fraser Univ., 

Canada, Univ. Paris Descartes and INSERM U567, Paris. 

C184 822.6 The involvement of CD2APp and endocytic 

proteins during enteropathogenic E. coli pedestal formation. 

J.A. Guttman, A.E. Lin, E. Veiga, P. Cossart and B.B. Finlay. 

Simon Fraser Univ., Canada, Univ. of British Columbia, Inst. 

Pasteur, Paris and Hosp. Univ. de Princesa, Madrid. 

C185 822.7 Nexilin is a component of enteropathogenic 

Escherichia coli pedestals. H.T. Law, J.S. Jackson and J.A. 

Guttman. Simon Fraser Univ., Canada. 

C186 822.8 Spectrin is a crucial component of EPEC 

pedestals. T.J. Ruetz and J.A. Guttman. Simon Fraser Univ., 

Canada. 

C187 822.9 Notch and transforming growth factor-beta 

signaling pathways cooperatively regulate vascular smooth 

muscle cell differentiation. Y. Tang and L. Liaw. Maine Med. 

Ctr. Res. Inst. 

C188 822.10 Leptin signaling through the PI3K-PDE3B 

pathway is impaired during chronic hypoxic exposure. D.G. 

Litvin, C.P. Tsipis, M.C. Puchowicz and J.C. LaManna. Case 

Western Reserve Univ. 

C189 822.11 A phenotypic study of intraflagellar transport 

and FLA10 in the lf4 mutant of Chlamydomonas reinhardtii. B. 

Meek, N. Wilson and K. Pargeter. Oklahoma State Univ. Col. 

of Osteo. Med. 

C190 822.12 An amphipathic alpha-helical domain identified 

in nucleoporins plays a role at the nuclear pore complex of 

Saccharomyces cerevisiae. M.D. Lazarus, P. Natarajan and 

S. Wente. Vanderbilt Univ. 

C191 822.13 Polymorphisms of the lamina maturation 

pathway and their association with the metabolic syndrome: the 

DESIR Prospective Study. B. Fontaine-Bisson, F. Fumeron, 

M. Marre, A. Dutour, C. Badens, N. Levy, J. Tichet, D-A. 

Tregouet, B. Balkau and P-E. Morange. Univ. of Ottawa, 

Xavier Bichat Med. Sch., Paris, INSERM U626 and U910, 

Marseille, Reg. Inst. for Hlth., Tours, INSERM U525, Paris and 

INSERM U780, Villejuif. 

823. Wound Healing, Tissue Repair and 

Regeneration 

Poster 



C192 823.1 Inflammation inhibits patterning but not 

dedifferentiation in amphibian limb regeneration. A.L. Mescher, 

A.W. Neff and M.W. King. Indiana Univ. Sch. of Med., 

Bloomington and Terre Haute. 

C193 823.2 Albumingel for cartilage and intervertebral 

disc regeneration prevents blood vessel formation. B. Scholz, 

C. Kinzelmann, K. Benz, Y. Baumer, J. Mollenhauer and B. 

Schlosshauer. Univ. of Tuebingen and TETEC AG Reutlingen, 

Germany. 

C194 823.3 The characteristics of rabbit and rat 

mesenchymal stromal cell growth and attachment to mesh used 

in hernia repair. D.L. Fagan, M. Lydic, H. Marie, P. Fredette, 

J. Heffner and H. Dorion. Youngstown State Univ. and Saint 

Elizabeth Hlth. Ctr. 

C195 823.4 Rotational stress impairs cutaneous wound 

healing in mice. A. Monte-Alto-Costa and B. Romana-Souza. 

State Univ. of Rio de Janeiro. 

C196 823.5 An animal model for simulating deep tissue 

injury for pressure ulcer research on spinal cord injury. M. 

Makhsous, F. Lin, A. Cichowski, A. Pandya and M. Modi. 

Northwestern Univ., Chicago and Rehab. Inst. of Chicago. 

C197 823.6 Upregulation proliferation and senescence 

markers in hyperplasia induced in mouse skin by sulfur mustard 

exposure. Y-C. Chang, J.D. Wang, M. Soriano, M.K. Gordon 

and D.R. Gerecke. Rutgers Univ., Piscataway. 

C198 823.7 Continuous measurement of negative 

pressure effects on cell migration in wounded monolayer cell 

with electrical wound-healing assay. C-C. Hsu, W-C. Tsai and 

J-S. Wang. Chang Gung Mem. Hosp.. Keelung and Linkou and 

Chang Gung Univ., Taiwan. 

C199 823.8 Effects of negative pressure on cell-cell 

junctions and cell migration. Y-M. Lu, C-C. Hsu and J-S. Wang. 

Chang Gung Mem. Hosp. at Keelung and Chang Gung Univ., 

Taiwan. 

C200 823.9 Myocardin-related transcription factor-A is a 

key regulator of myofibroblast formation and function. B. Crider, 

G. Risinger, Jr., E. Howard, C. Haaksma and J.J. Tomasek. 

Univ. of Oklahoma Hlth. Sci. Ctr. 

C201 823.10 Ectopic telomerase expression in Dupuytren’s 

disease myofibroblasts. M.B. Vaughan, J.J. Tomasek, M.C. 

Noon and A.M. Isiaho. Univ. of Central Oklahoma and Univ. of 

Oklahoma Hlth. Sci. Ctr. 

254

tuesday 

C202 823.11 Antioxidant effect on myofibroblast 

differentiation. T.R. Palmer and M.B. Vaughan. Univ. of Central 

Oklahoma. 

C203 823.12 Clonal analysis of myofibroblast differentiation. 

S. Chukwuma and M. Vaughan. Univ. of Central Oklahoma. 

C204 823.13 Aging causes accumulation of nonproliferative 

adipose-derived stem cells that is attenuated by caloric 

restriction in mice. E.G. Schmuck, J.D. Mulligan and K.W. 

Saupe. Univ. of Wisconsin-Madison. 

824. Muscle: Stem Cells and Regeneration 

Poster 



C205 824.1 Upregulation of Sca-1 in satellite cells 

during diaphragmatic skeletal muscle regeneration: potential 

novel mechanism of skeletal muscle regeneration. B.M. 

Rezk, T. Yoshida, L. Semprun-Prieto, S. Sukhanov and P. 

Delafontane. Tulane Univ. 

C206 824.2 Oxygen concentration modulates in vitro 

differentiation of porcine muscle-derived stem cells. P.T. 

Loughna and Z. Redshaw. Sch. of Vet. Med. and Sci., Univ. of 

Nottingham. 

C207 824.3 Bioengineered skeletal muscle for defect 

replacement in a rodent model. M.A. Machingal, B.T. Corona, 

V. Kesireddy, K. Andersson, M. Herco, S. Vishwjit, B. 

Bishwokarma, W. Zhao, J.J. Yoo and G.J. Christ. Wake 

Forest Sch. of Med. and Virginia Tech-Wake Forest Univ. Sch. 

of Biomed. Engin. and Sci. 

C208 824.4 Angiotensin II signalling regulates skeletal 

muscle growth and myoblast chemotaxis. A. Johnston, J. 

Baker, L. Bellamy, M. De Lisio and G. Parise. McMaster 

Univ., Canada. 

C209 824.5 Efficient myogenic commitment of hESCs and 

iPSC-derived cells on biomimetic materials replicating myoblast 

topography. N.S-y. Hwang and R.S. Langer. MIT. 

C210 824.6 Functional heterogeneity of muscle satellite 

cells in both somite-derived and branchiomeric muscles. Y. 

Ono, L. Boldrin, P. Knopp, J.E. Morgan and P.S. Zammit. 

King’s Col. London and University Col. London. 

C211 824.7 FACS analysis and immunohistochemical 

analysis of human myogenic stem cell number and cell-cycle 

kinetics in response to acute myotrauma. B. McKay, K. Toth, M. 

Tarnopolsky and G. Parise. McMaster Univ., Canada. 

C212 824.8 Dose-response relationship of human CD34 + 

cells in an athymic rat model of myocardial infarction. B. 

Brooks, J. McKee, D. Rice, B. Baumgartner, D. Motlagh 

and D. Amrani. Baxter Healthcare Corp., Round Lake and 

Deerfield, IL. 

825. Anatomy Education: Computer-Assisted 

Learning 

Poster 



C213 825.1 Anatomical education: bringing a dead 

science to life through a hybrid online approach. M.T. Bee, G. 

Grabowski and J. Montante. Oakland Univ. William Beaumont 

Sch. of Med. and Univ. of Detroit Mercy. 

anatomy 

C214 825.2 Using QuickTime videos of cone beam 

computed tomography of the mandible in the instruction of 

first year dental students. K.D. Smith, T.F. Lanphier, M.A. 

Jergenson, P.C. Edwards, T.S. Saini and N.S. Norton. 

Creighton Univ. and Univ. of Michigan. 

C215 825.3 Virtual pelvic anatomy simulator improved 

medical student comprehension of pelvic anatomy. J.P. 

Hassinger, E.J. Dozois, S.D. Holubar, W. Pawlina, R. 

Pendlimari, J.L. Fidler, D.R. Holmes and R.A. Robb. Mayo 

Med. Sch. and Mayo Clin. 

C216 825.4 3D-X: making spatial sense of cross-sectional 

anatomy in an online learning environment. S. Bhattacharyya, 

K. Dorosh, T. Wilson and M. Johnson. Univ. of Western 

Ontario. 

C217 825.5 Development of a synchronous online 

microscopic anatomy course using virtual microscopy. M. 

Barbeau and K. Rogers. Univ. of Western Ontario. 

C218 825.6 Low cost, high impact video system for use in a 

gross anatomy laboratory. E.M. Goldman. Sch. of Sci. & Hlth., 

Philadelphia Univ. 

C219 825.7 Student interaction with a novel computer 

interface in a gross anatomy lab. E.M. Goldman. Sch. of Sci. & 

Hlth., Philadelphia Univ. 

C220 825.8 Evaluation by medical students of a new 

computer-based dissection manual. B. Kraszpulska and R. 

Gainor. Wright State Univ. 

C221 825.9 Production and assessment of interactive 

animations for medical education. J.R. Fredieu, J. Watson, 

C. Hughart, A. Almon and T. Nikiforova. Sch. of Med., Case 

Western Reserve Univ. and Cleveland Inst. of Art. 

C222 825.10 Evaluation of computer visualizations 

developed for anatomy education. N. Nguyen, A. Nelson and 

T. Wilson. Univ. of Western Ontario. 

826. Anatomy Education: Clinical Based 

Learning 

Poster 



C223 826.1 Integrating anatomical and clinical illustrations 

in a teaching format. D. Cui, J.C. Lynch, G. Yang and D.E. 

Haines. Univ. of Mississippi Med. Ctr. 

C224 826.2 Cadaver programs at the undergraduate level: 

student-led dissection with a focus on exploring pathologies 

and anatomical variations. V. Flynn, I. Blackmon, A. Darkow, 

N. Nekouian, K. Schulte and A.C. Potterfield. Westminster 

Col., MO. 

C225 826.3 iMorphology: integrative, blended teaching of 

anatomy and diagnostic imaging. J. Streicher. Med. Univ. of 

Vienna. 

C226 826.4 Use of CT imaging to enhance learning of gross 

anatomy in medical curriculum. C.P. Nyauncho, J.M. Barlow, 

K. Christensen, E.A. Scoville, J.P. Hassinger, N. Kumar, N. 

Lachman and W. Pawlina. Mayo Med. Sch. and Mayo Clin. 

C227 826.5 Cadaver computed tomography as a tool for 

teaching anatomy: an update. S.H. Ellozy, S. Lerner, J.S. 

Reidenberg, J. Weintraub, M.L. Marin and J.T. Laitman. 

Mount Sinai Sch. of Med. 

C228 826.6 Promoting student scholarship: a web-based 

peer-reviewed educational resource. W.G. Pearson, A. 

Zumwalt and T. Hoagland. Boston Univ. Sch. of Med. 

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anatomy 

C229 826.7 Diagnosis of pediatric intussusception using 

point of care ultrasound in the pediatric emergency department. 

B.M. Halm, R.B. Boychuk and A.A. Franke. Kapiolani Med. 

Ctr. for Women and Children, Univ. of Hawaii John A Burns Sch. 

of Med. and Cancer Res. Ctr. of Hawaii, Honolulu. 

C230 826.8 Designing a PBL curriculum that enhances 

education opportunities for general medical practitioners in 

Mozambique. E.R. Walker, H. Billings, A. Gomes, M. Inroga 

and J. Pearson. West Virginia Univ., Univ. of Pittsburgh and 

Catholic Univ. of Mozambique. 

C231 826.9 The development of a web-based module 

on gestational diabetes mellitus for patients and healthcare 

professionals. A. Clancy, M. Johnson, A. Watson, T. Paul and 

M. Mottola. Univ. of Western Ontario. 

827. Anatomy Education: Teaching Methods 

and Innovations 

Poster 



C232 827.1 Increased presence of peer teaching and 

teamwork in gross anatomy. P. Bernd and B. Richards. 

Columbia Univ. 

C233 827.2 Peer teaching as an educational tool for 

learning basic concepts of the peripheral nervous system. A.R. 

Severson. Univ. of Minnesota Med. Sch.-Duluth. 

C234 827.3 The BioNetLab Anatomy Collaboratory. M.J. 

Pescitelli, C. Lilagan, S. Huntley, S. Landers, E. Theiss and 

M. Doyle. Univ. of Illinois Col. of Med. at Chicago and Iomas 

Technol. LLC and Buonacorsi Fndn., Wheaton, IL. 

C235 827.4 Popularity versus effectiveness of two methods 

to teach gross anatomy: a preliminary study. A. Cochran and 

C. Nichols. Med. Col. of Georgia. 

C236 827.5 Diffusion of innovations: use of mobile 

technology for point-of-contact clinical anatomy learning 

resources. R. Trelease. David Geffen Sch. of Med. at UCLA. 

C237 827.6 Public domain (copyright free) resources in 

human gross anatomy. G.H. Albrecht. USC Keck Sch. of Med. 

C238 827.7 Development of a scientist-educator program. D. 

Bader, A.F. Dalley, J.J. Norden, L.B. Nanney, C.C. Pettepher, 

A.W. Richmond, S. Wente and R. Chalkley. Vanderbilt Univ. 

C239 827.8 Personalizing embryology teaching to increase 

interest and clinical relevance. V. Lyons. Dartmouth Med. Sch. 

C240 827.9 The clinical relevance of teaching the medial 

line theme of the lower limb to future healthcare professionals. 

B. Benninger. Oregon Hlth. & Sci. Univ. 

C241 827.10 Exercises to encourage analytical skills and 

enrich understanding in a pre-baccalaureate anatomy course. 

S.A. Miller. Hamilton Col., NY. 

C242 827.11 Understanding protein synthesis: a role 

play approach in large undergraduate human anatomy and 

physiology classes. D. Sturges and T. Maurer. Georgia 

Southern Univ. 

828. Anatomy Education: Assessment, 

Curriculum and Mentoring 

Poster 

Tuesday 



C243 828.1 Experience of true life: a qualitative inquiry of 

first-year medical students’ experience of cadaver dissection. 

M.D. Skinner, S. Morrow and D.A. Morton. Univ. of Utah. 

C244 828.2 Death is only the beginning: cadaver use at 

Indiana University. P. Husmann. Indiana Univ. 

C245 828.3 The logistics of facilitating a dissection-based 

anatomy curriculum in a distributed medical program. J. Fraser, 

E. Mogerman and C. Krebs. Univ. of British Columbia. 

C246 828.4 The outcomes logic model: an approach 

for program planning and evaluation; taking successful pilot 

programs to scale; evolution of TBL anatomy program. N. 

Vasan and D. DeFouw. UMDNJ-New Jersey Med. Sch. 

C247 828.5 Evaluating quality of medical students’ 

dissections in the gross anatomy laboratory. N. Kumar, J.P. 

Hassinger, E.A. Scoville, K. Christensen, C.P. Nyauncho, N. 

Lachman and W. Pawlina. Mayo Med. Sch. 

C248 828.6 Medical gross anatomy laboratory tours have 

a positive impact on participant interest in the health care 

professions. C.M. Eckel, R.L. Pratt, D. Hermey and J.B. 

Hanna. West Virginia Sch. of Osteo. Med. and Lincoln Mem. 

Univ., TN. 

C249 828.7 Using gross anatomy as a predictor of academic 

success in a post-baccalaureate program. N.S. Norton, M.A. 

Jergenson, L.C. Barritt and F.J. Ayers. Creighton Univ. 

C250 828.8 Using histology as a predictor of academic 

success in a post-baccalaureate program. L.C. Barritt, M.A. 

Jergenson, N.S. Norton and F.J. Ayers. Creighton Univ. 

C251 828.9 Student-centered collaborative learning in 

a medical histology course through virtual microscopy and 

team-based learning. G. Enfield, D. DeFouw and N. Vasan. 

UMDNJ-New Jersey Med. Sch. 

C252 828.10 Digital photography versus anatomical 

illustration: which method is more accurate J.S. Reidenberg, 

N. Asch and J.T. Laitman. Mount Sinai Sch. of Med. 

829. Anatomy Education: Educational 

Research 

Poster 



C253 829.1 Anatomical dissection: youthful or mature 

inexperience R. Ettarh and G.F. Perry. Sch. of Med. and Med. 

Sci., Univiversity Col. Dublin. 

C254 829.2 Assessment of biomedical students 

performance in human anatomy. N.M. Afifi, H.W. Bargal and 

A. Al Thani. Qatar Univ. 

C255 829.3 How dental students are taught the anatomical 

sciences: survey results from North American basic science 

course directors. H.W. Lambert, D.J. Gould, D.T. Burk, L.M.J. 

Lee, S. Atsas and B. Hutchins. West Virginia Univ. Sch. of 

Med., Ohio State Univ. Col. of Med., Univ. of Pacific Dugoni Sch. 

of Dent. and Texas A&M Hlth. Sci. Ctr. Baylor Col. of Dent. 

256

tuesday 

C256 829.4 Effectiveness of a web-based cross-sectional 

anatomy learning tool (3D-X) at improving students’ ability to 

interpret CT images. K. Dorosh, S. Bhattacharyya and P. 

Haase. Univ. of Western Ontario. 

C257 829.5 Testing knowledge of clinically-relevant surface 

anatomy. M. Hankin, C.A.C. Baptista, R.D. Lane, D.E. Morse 

and C.A. Bennett-Clarke. Univ. of Toledo. 

Biochemistry/anatomy 

C258 829.6 Correlating numerical course grades between 

gross anatomy and clinical courses with strong orthopedic 

content in the physical therapy curriculum. T.P. Bukoskey and 

R. Barredo. Tennessee State Univ. 

Biochemistry and Molecular Biology 

830. Chromatin Structure and Remodeling 

Poster 



B1 830.1 A functional role for CHD8 in transcriptional 

regulation through the modulation of chromatin structure. D.A. 

Bochar, T. Menon and J.A. Yates. Univ. of Michigan. 

B2 830.2 Changes of antioxidant activity and phenolic 

compounds during fermentation by lactic acid bactera. J. 

Jung, J.H. Shin and S.K. Yoo. Sookmyung Women’s Univ. and 

Joongbu Univ., Republic of Korea. 

B3 830.3 Identification of novel regulatory domains 

in the yeast Snf2 protein. P. Sen, S. Ghosh, F. Pugh and B. 

Bartholomew. Southern Illinois Univ. and Penn State. 

831. Co-Transcriptional Processing 

Poster 



B4 831.1 Chemical-genomic dissection of the CTD code. 

A.Z. Ansari. Univ. of Wisconsin-Madison. 

B5 831.2 Sem1 is required for TREX2 stability. E.G. 

Oliver, P.P. García and S.R. Navarro. Ctr. Invest. Príncipe 

Felipe, Valencia. 

B6 831.3 A genome-wide RNAi screen identifies novel 

factors involved in the processing of snRNA. E.J. Wagner, T.R. 

Albrecht, J. Chen and N. Ezzeddine. Univ. of Texas Hlth. Sci. 

Ctr. at Houston. 

832. Mechanisms of Chromatin Remodeling 

Poster 



B7 832.1 Structural studies of ATP-dependent chromatin 

remodeling. A. Leschziner, B. Isaac, C.R. Clapier and B.R. 

Cairns. Harvard Univ. and HHMI, Univ. of Utah Sch. of Med. 

833. Transcriptional Regulation 

Poster 



B8 833.1 Inhibition of Notch is directly correlated with 

VPAC repression in HT-29 colon carcinoma cells. D.S. Bakke, 

K.D. Benton, R. Hermann, G. Dorsam and D.S. Bakke. North 

Dakota State Univ. 

B9 833.2 Ikaros engages the VPAC1 promoter and 

recruits HDAC1 in activated HuT78 cells. K.D. Benton, R.J. 

Hermann, T. Van der Steen, J. Failing and G.P. Dorsam. 

North Dakota State Univ. 

B10 833.3 Regulation of transcription factor AP-1 in 

human fibroblasts in response to cytokines: role in regulation 

of matrix metalloproteinase-3. R. Borghaei, M. Chambers, G. 

Gorski and G. Kirkpatrick. Philadelphia Col. of Osteo. Med. 

B11 833.4 Role of STAT6 in regulation of matrix 

metalloproteinase-3. R. Borghaei, M. Chambers, C. Gunsolly, 

G. Gorski and M. Evans. Philadelphia Col. of Osteo. Med. 

B12 833.5 Examining the influence of the sulfur 

assimilation pathway on the regulation of Yap1 activity in 

Saccharomyces cerevisiae. H.A. Brown and J.D. West. Col. of 

Wooster. 

B13 833.6 Saccharomyces cerevisiae responds to cold 

shock by inducing the transcription of genes required for zinc ion 

homeostasis. K.M. Buckmelter, B.A. Infanzon, E.M. Liu, O.S. 

Sakhon, K.R. Rodriguez and W.T. Citti. Loyola Marymount 

Univ. 

B14 833.7 Tungsten carbide-cobalt nanoparticles induce 

reactive oxygen species, AKT, ERK, AP-1, NF-kB, VEGF, and 

angiogenesis. M. Ding, J. Zhao, L. Bowman, V. Castranova 

and B-H. Jiang. 

B15 833.8 Roles of the yeast Ccr4-Not complex in 

regulating transcription. A. Dutta, J.A. Kruk, D.S. Gilmour and 

J.C. Reese. Penn State. 

B16 833.9 Can neuropeptide receptors really cause 

leukemogenesis. J. Failing, S. Dorsam, R. Hermann, S. Batra 

and G. Dorsam. North Dakota State Univ. and MeritCare Hlth. 

Systs., Fargo. 

B17 833.10 Phospholipase C is required for histone 

acetylation in Saccharomyces cerevisiae. L. Galdieri and A. 

Vancura. St. John’s Univ., NY. 

B18 833.11 Genome wide mapping of histone methylation 

reveals a distinct epigenomic signature in human pluripotent 

stem cells. M.J. Hitchler, C.S. Veerappan, J. Aman, V. Fox, C. 

Cuningham, D. Van Den Berg, B. Berman, M. Pera, P. Laird 

and J.C. Rice. Univ. of Southern California. 

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iochemistry 

B19 833.12 DNA sequence specificity of alternatively 

spliced TCF1E. N.P. Hoverter, J.H. Ting and M.L. Waterman. 

Univ. of California, Irvine. 

B20 833.13 Saccharomyces cerevisiae responds to cold 

shock by inducing the transcription of ribosome biogenesis 

genes. B.A. Infanzon, K.M. Buckmelter, E.M. Liu, O.S. 

Sakhon, W.T. Citti and K.D. Dahlquist. Loyola Marymount 

Univ. 

B21 833.14 Phenotypic and functional genomic analysis 

of heat and cold stress in transcription factor deletion strains 

of Saccharomyces cerevisiae. L.N. Kubeck, K.R. Rodriguez, 

K.C. Entzminger, S.D. Kuelbs, K.B. Hubbard and K.D. 

Dahlquist. Loyola Marymount Univ. 

B22 833.15 Retinoic acid enhances natriuretic peptide 

receptor-A gene transcription: role of additive effect of retinoic 

acid receptor-a and Ets-1. P. Kumar, G. Bolden and K.N. 

Pandey. Tulane Univ. Hlth. Sci. Ctr. 

B23 833.16 Transcriptional regulation of the lysyl oxidase 

gene by the hypoxia-inducible factor 1. W. Li, Y. Zhao, S. Gao 

and P. Toselli. Boston Univ. Sch. of Med. 

B24 833.17 PC4 is a coactivator for basal and TSA-induced 

luteinizing hormone receptor transcription. M. Liao, Y. Zhang 

and M.L. Dufau. NICHD, NIH. 

B25 833.18 Neuropeptides and colon cancer; another 

Notch in the complexity of tumorigenesis. N.G. Light, K.D. 

Benton, R.J. Hermann, J. Failing and G.P. Dorsam. North 


B26 833.19 TREM-2, an innate immune receptor, is 

dependent on C/EBPalpha and PU.1 transcription factors during 

the differentiation of hematopoietic stem cells to macrophages. 

M.M. Mancarelli, C. Derossi and B.E. Torbett. The Scripps 

Res. Inst. 

B27 833.20 Binding of nBmp2 to PLSCR suggests a 

possible mechanism for nBbmp2 regulation of Ca 2+ -modulating 

proteins. B.T. McCune, C.L. Fox, A.D. Schmidt, J.L. Mayo, 

M.J. Finley and L. Bridgewater. Brigham Young Univ. 

B28 833.21 Regulation of alpha-fetoprotein expression in 

the mouse liver by HNF1 and NF1. H. Ren and B. Spear. Univ. 

of Kentucky. 

B29 833.22 Genetic evidence for PKCD signaling in 

thrombin-induced NF-kB activation in endothelial cells. V. 

Singh, P.B. Thippegowda, P.C. Sundivakkam, S.M. Vogel, 

A.B. Malik, R.D. Ye and C. Tiruppathi. Univ. of Illinois at 

Chicago. 

B30 833.23 Molecular mechanisms of a disease 

susceptibility variant of SIRT1: genotoxic stress-induced, 

CTCF-dependent activation of SIRT1 gene expression. X. 

Song, M. Cho, J. Han, H. Hazuda, R. Duggirala, J. Blangero, 

M.G. Rosenfeld and Y. Suh. Sch. of Med. and HHMI, UCSD 

and Albert Einstein Col. of Med. 

B31 833.24 Histone H4 lysine 20 mono methylation at 

specific genomic sequences induces transcriptional repression. 

C.S. Veerappan, L.M. Congdon, S.I. Houston, T.M. Spektor 

and J.C. Rice. Univ. of Southern California. 

B32 833.25 Overexpression of Act1 drives beta-defensin 

expression. S. Velichko, J.D. Anderson, O. Li, F. Huang and 

R. Wu. Univ. of California, Davis and Penn State. 

B33 833.26 An androgen response-like element half-site 

is essential for androgen regulation of gonadotropin regulated 

testicular RNA helicase (GRTH/DDX25) transcription. J. Villar, 

C-H. Tsai-Morris and M.L. Dufau. NICHD, NIH. 

B34 833.27 KLF 4 is involved in ATRA-induced mitofusin 2 

expression in vascular smooth muscle cells. R. Zhang, M. Han, 

B. Zheng, Y-j. Li, Y-n. Shu and J-k. Wen. Hebei Med. Univ., 

People’s Republic of China. 

258 

834. Chaperones 

Poster 




B35 834.1 Characterization of the small heat shock 

protein aB-crystallin chaperone binding regions in human gDcrystallin 

using single domain constructs of gD-crystallin. L. 

Acosta-Sampson and J. King. MIT. 

B36 834.2 Novel phosducin-like protein 1 interactions. 

A. Gray, A. Howlett, J. Prince, N. Ahn and B.M. Willardson. 

Brigham Young Univ. and Univ. of Colorado at Boulder. 

B37 834.3 The group II chaperonin Mm-Cpn binds and 

refolds mutant H[&gamma]D crystallin to a native-like structure. 

K.M. Knee, D.R. Goulet, K. Moreau and J. King. MIT. 

B38 834.4 Human aB-crystallin binds to and suppresses 

the aggregation of human gD-crystallin congenital cataract 

mutants. K. Moreau, L. Acosta Sampson and J. King. MIT. 

835. Enzyme Kinetics 

Poster 



B39 835.1 Probing the active site of Thermotoga maritima 

adpglucose pyrophosphorylase. A. Arteaga, M. Matsui, A. 

Orry and C.R. Meyer. California State Univ., Fullerton and 

Molsoft LLC, La Jolla. 

B40 835.2 The role of methionine residues in activity and 

subunit communication in malate dehydrogenase. F. Billue 

and E. Bell. Univ. of Richmond. 

B41 835.3 Insights into the function of the a-helical tail 

of Haemophilus influenzae 3-deoxy-d-manno-octulosonate 

8-phosphate phosphatase. A.D. Hanuszkiewicz, L. Briski and 

R. Woodard. Col. of Pharm., Univ. of Michigan and Kalamazoo 

Col. 

B42 835.4 The effects of flow on the activation of bovine 

prothrombin by prothrombinase at physiologically relevant 

shear rates. L.M. Haynes, Y. Dubief, T. Orfeo and K.G. Mann. 

Univ. of Vermont, Colchester and Burlington. 

B43 835.5 A novel secondary alcohol dehydrogenase 

from Micrococcus luteus WIUJH20: purification, cloning, and 

properties. J-K. Huang, J.K. Park, B.R. Dhungana, N.D. 

Youngblut, C-T. Lin and L. Wen. Western Illinois Univ. and 

Natl. Taiwan Ocean Univ. 

B44 835.6 The role of G51 and I140 in glyoxasomal 

malate dehydrogenase. R. Jones, R. Gruner and E. Bell. Univ. 

of Richmond and Robious Middle Sch., Midlothian, VA. 

B45 835.7 Nicotinic acid degradation in Bordetella 

bronchiseptica: mechanistic studies of the novel enzyme NicF. 

V.A. Kincaid. Col. of Wooster. 

B46 835.8 Engineering platelet-activating factor 

acetylhydrolase as a catalytic bioscavenger for 

organophosphorus compounds. S. Kirby, J. Norris, D. Cerasoli 

and B. Bahnson. U.S. Army Med. Res. Inst. of Chem. Def., 

Aberdeen Proving Ground, MD and Univ. of Delaware. 

B47 835.9 Activity studies of Epulopiscium type B 

1,3-b-glucanase. K.L. Lajeunesse and A.J. Piefer. Hartwick 

Col., NY.

tuesday 

B48 835.10 Characterization of the Thermotoga maritima 

ADP-glucose pyrophosphorylase: both glgC and glgD subunits 

are required for optimal activity and allosteric regulation. M. 

Matsui, E. Guandique, M. Tran, S. Nisperos, A. Orry and 

C.R. Meyer. California State Univ., Fullerton and Molsoft LLC, 

La Jolla. 

B49 835.11 Engineering human paraoxonase-1 double 

mutants to hydrolyze organophosphorus compounds. J. Norris, 

M. Chung, J.R. Smith and S. Kirby. U.S. Army Med. Res. Inst. 

of Chem. Defense, Aberdeen Proving Ground, MD. 

B50 835.12 Kinetic characterization of a BCP-class 

peroxiredoxin from Escherichia coli. S.A. Reeves, D. 

Parsonage, K.J. Nelson and L.B. Poole. Wake Forest Univ. 

Sch. of Med. 

B51 835.13 Cloning, expression and purification of yeast 

aminotransferase. Z.L. Reyes, W.E. Karsten, K.D. Bobyk, P.F. 

Cook and L. Chooback. Univ. of Central Oklahoma and Univ. 

of Oklahoma. 

836. Photochemical Sensors 

Poster 



B52 836.1 Measuring readily exchangeable zinc in 

Escherichia coli by carbonic anhydrase-based expressible 

ratiometric zinc sensor. D. Wang, T.K. Hurst, C.A. Fierke and 

R.B. Thompson. Univ. of Michigan and Univ. of Maryland Sch. 

of Med. 

837. Protease: Structure and Regulation 

Poster 



B53 837.1 Identification of a receptor-induced binding site 

in plasminogen induced by its interaction with cells. J. Han, R.J. 

Parmer and L.A. Miles. The Scripps Res. Inst. and UCSD and 

VA San Diego Healthcare Syst. 

B54 837.2 Localization and purification of phagosomeassociated 

proteases in Tetrahymena thermophila. T. Kaur, 

J.R. Carreon and J.W. Straus. Vassar Col. and Ramapo Col. 

of New Jersey. 

B55 837.3 Enhancing the catalytic activity of an 

engineered threonine protease. M. Lansang and T. Baird, Jr. 

San Francisco State Univ. 

B56 837.4 Introducing extended substrate selectivity into 

trypsin through redesign. S.P. Najibi and T. Baird, Jr. San 

Francisco State Univ. 

B57 837.5 Structural analysis of HIV-1 protease inhibition 

using physical models. Lincoln SMART Team, S. Colton, T. 

Herman, K. Giles, B. Koo, S. Jeske, N. Ollikainen and J. 

Reis. Lincoln H.S., San Francisco, Milwaukee Sch. of Engin. 

and UCSF. 

B58 837.6 Asn 362 contributes to zinc binding by leukotriene 

A 4 

hydrolase. M.W. Thompson, A. Schaible and R.L. Seipelt. 

Middle Tennessee State Univ. 

B59 837.7 Role of the reactive center loop of protein Z 

dependent protease inhibitor in determining specificity of the 

protease reaction. L. Yang and A.R. Rezaie. Saint Louis Univ. 

838. Protein Synthesis, Catalysis and 

Turnover 

Poster 

Biochemistry 



B60 838.1 Use of RNA affinity chromatography to 

investigate factors involved in selenoprotein synthesis and 

nonsense decay. M.J. Berry, L. Seale, C.L. Gilman and A. 

Seyedali. Univ. of Hawaii at Manoa. 

B61 838.2 Covalent modification of proteins by a small 

peptide Zfra. N-S. Chang, M-H. Lee and S-R. Lin. ‘Natl. Cheng 

Kung Univ. Med. Col., Taiwan and SUNY Upstate Med. Univ. 

B62 838.3 Single molecule structural dynamics of 

ribosome before and during translocation. B.S. Cooperman, 

C. Chen, B. Stevens, H. Liu, D. Cabral, H. Zhang, J. Kaur, 

Y. Wang, D. Pan, Z. Smilansky and Y.E. Goldman. Univ. of 

Pennsylvania, Univ. of Houston and Anima Cell Metrology Inc., 

Bernardsville, NJ. 

B63 838.4 Interrupted catalysis: the EF4 (LepA) effect 

on back translocation. H. Liu, D. Pan, M. Pech and B.S. 

Cooperman. Univ. of Pennsylvania, Harvard Univ., Boston and 

Max Planck Inst. for Molec. Genet., Berlin. 

B64 838.5 Signal transduction on the ribosome:timing 

EF-Tu release from aminoacyl-tRNA. W. Liu, K. Poruri, W. 

Mandecki, Y.E. Goldman and B.S. Cooperman. Univ. of 

Pennsylvania and UMDNJ, Newark. 

B65 838.6 Facile chemoenzymatic platform for protein 

tyrosine-sulfate production. L.Y. Lu, B.H. Chen, J.Y-S. Wu, T.A. 

Liu, D.H. Chen, C.C. Wang, T.H. Lin, C.C. Hsu and Y.S. Yang. 

Natl. Chiao Tung Univ., Taiwan. 

B66 838.7 Generating permissive site-specific unnatural 

amino acid synthetases. R.A. Mehl, S.J. Miyake-Stoner and 

C.A. Refakis. Franklin & Marshall Col. 

B67 838.8 Utilizing elongation factor Tu mutagenesis to 

incorporate large unnatural amino acids in vivo. J.C. Peeler 

and R.A. Mehl. Franklin & Marshall Col. 

B68 838.9 Determination of protein synthesis in vivo with 

15 

N-glycine labeling and MALDI-TOF spectrum analysis. P.N. 

Wahjudi, G.G. Xiao, W.N.P. Lee, M.W. Nowak and N. Shiva. 

Los Angeles Biomed. Res. Inst., Creighton Univ. Med. Ctr. and 

Endcode Bio Inc. and Proteio Inc., Pasadena. 

839. Protein Turnover and Quality Control 

Poster 



B69 839.1 Biochemical characterization of the cellular 

biosynthesis and trafficking of Caspr2. G. Falivelli, C. Davide, 

N. Dubi, A. De Jaco, J. Wilson and P. Taylor. Skaggs Sch. of 

Pharm. and Pharmaceut. Sci., UCSD. 

B70 839.2 Premature translation termination products are 

substrates for the rapidly degraded polypeptide pathway. J.R. 

Lacsina, X. Liu and C.V. Nicchitta. Duke Univ. Med. Ctr. 

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iochemistry 

840. Protein Turnover in Cell Regulation 

Poster 



B71 840.1 Regulation of cyclin E stability in Xenopus 

embryos. Y. Brandt, T. Mitchell, Y. Wu and R. Hartley. Univ. of 

New Mexico Hlth. Sci. Ctr. 

841. Protein Turnover: Function and 

Regulation of the 26S Proteasome 

Poster 



B72 841.1 The immunoproteasome, the 20S proteasome, 

and the Pa28ab proteasome regulator are oxidative stressadaptive 

proteolytic complexes. A.M. Pickering, A.L. Koop, 

C.T. Pimental, G. Ermak, T. Grune and K.J.A. Davies. Univ. of 

Southern California and Heinrich Heine Univ. Duesseldorf. 

B73 841.2 Stimulation of adrenergic receptors regulates 

proteasome function in cardiomyocytes. M.J. Ranek and X. 

Wang. Univ. of South Dakota. 

B74 841.3 Activation of muscarinic receptor 2 stimulates 

proteasome function in cardiomyocytes. M.J. Ranek and X. 

Wang. Univ. of South Dakota. 

842. Protein Turnover: Tagging Substrates 

for Ubiquitination 

Poster 



B75 842.1 Processing of the ubiquitin-like autophagic 

protein LC3 by the 20S proteasome. X. Jiang, Z. Gao, N. 

Gammoh, P-M. Wong, H. Erdjument-Bromage and P. 

Tempst. Mem. Sloan-Kettering Cancer Ctr. 

B76 842.2 Molecular mechanism of the ubiquitin 

conjugating enzyme E2-25K to synthesize the polyubiquitin 

chains. D.Y. Shin, E.S. Park and Y.J. Yoo. Gwangju Inst. of Sci. 

& Technol., Republic of Korea. 

B77 842.3 HIP E3 ligase and USP2 deubiquitinating 

enzyme antagonistically control AIF-mediated programmed 

cell death. S.W. Yang, K.H. Oh, J.M. Park, Y.J. Jeon and C.H. 

Chung. Sch. of Biol. Sci., Seoul Natl. Univ. 

843. Ubiquitin: Pathways, Targeting, and 

Pathogenesis 

Poster 



B78 843.1 SUMO modification of the Polycomb group 

protein Sex Comb on Midleg counteracts its function as a 

repressor of homeotic genes. A.J. Courey, M. Smith, J.A. 

Simon and D.R. Mallin. UCLA and Univ. of Minnesota, 

Minneapolis. 


B79 843.2 Small-ubiquitin-like modifier in Tetrahymena 

thermophila. S.L. Matejka, A. Knobbe, J. Johnson, D.P. 

Weeks and C. Bailey. Univ. of Nebraska-Lincoln. 

B80 843.3 Molecular mechanisms of TRAF6 ubiquitination 

and activation. K.Z.Q. Wang, A-J. Su, J. Adamik, D.L. Galson 

and P.E. Auron. Duquesne Univ. and Univ. of Pittsburgh. 

844. Biochemistry and Physiology of Plant 

Lipids 

Poster 



B81 844.1 Temperature-sensitive, post-translational 

regulation of plant omega-3 fatty acid desaturases is mediated 

by the ER-associated degradation pathway. D. Zhang, J. 

O’Quin, L. Bourassa, S. Foss, J. Shocky, S. Gidda, K. 

Chapman, R. Mullen and J. Dyer. U.S. Arid Land Agr. Ctr., 

Maricopa, AZ, Univ. of New Orleans, USDA, New Orleans, 

Univ. of Guelph, Canada and Univ. of North Texas. 

845. Cellular Lipid Movement and 

Compartmentalized Metabolism 

Poster 



B82 845.1 FATP4 contributes as an enzyme to the insulinmediated 

fatty acid uptake of C2C12 muscle cells. M. Digel, 

S. Staffer, W. Stremmel, R. Ehehalt and J. Fuellekrug. Univ. 

Hosp. Heidelberg, Germany. 

B83 845.2 Compartmentalization of eicosanoid 

substrates, signaling lipids, and enzymes into nanoparticles in 

human cerebrospinal fluid. A.N. Fonteh, E. Oborina and M. 

Harrington. Huntington Med. Res. Insts., Pasadena. 

B84 845.3 Targeting of acyl-CoA synthetase 3 to lipid 

droplets. J. Fuellekrug, R. Grossmann, B. Rudolph, M. 

Becker, C. Thiele, W. Stremmel, R. Ehehalt and M. Digel. 

Univ. Hosp. Heidelberg and LIMES Inst., Bonn. 

B85 845.4 The role of Arv1 in sterol metabolism and its 

contribution to the unfolded protein response. C.F. Shechtman, 

A. Henneberry, T. Seimon, I. Tabas and S.L. Sturley. Columbia 

Univ. 

846. Non-animal Genetic Models of Lipid 

Metabolism 

Poster 



B86 846.1 Regulation and physiological roles of the 

phospholipase B’s encoded by PLB1-3 in Saccharomyces 

cerevisiae. B. Surlow, A. Bishop and J. Patton-Vogt. 

Duquesne Univ. 

260

tuesday 

847. Organelle Lipid Biosynthesis 

Poster 



B87 847.1 Extraction and evaluation of gangliosidelike 

material in Lactobacillus bacterium. A.J. Sawdon, A.C. 

Ettinger and K.H. Moore. Oakland Univ., MI. 

848. Phosphatidylinositol Signaling 

Poster 



B88 848.1 Prohibitin interacts with phosphatidylinositol 

3,4,5-triphosphate and modulates insulin signaling. S.R. Ande 

and S. Mishra. Univ. of Manitoba. 

849. Stress and Lipid Metabolism 

Poster 



B89 849.1 Characterization of a coenzyme Q biosynthetic 

complex in Saccharomyces cerevisiae. C.M. Allan, U. Tran, M. 

Gulmezian, B.N. Marbois and C. Clarke. UCLA. 

B90 849.2 Isotope-reinforced polyunsaturated fatty acids 

protect yeast cells from oxidative stress. C.F. Clarke, V.V. 

Shmanai, K. Hirano, S. Hill, B. Kay, V. Tse, B.N. Marbois, R.J. 

Molinari and M. Shchepinov. UCLA, Inst. of Phys. Organic 

Chem., Minsk, Belarus and Retrotope, Los Altos Hills, CA. 

B91 849.3 Zhx2 protects the liver from high fat-induced 

liver damage. E.L. Fleishaker, M. Peterson and B. Spear. 

Univ. of Kentucky. 

B92 849.4 Modeling changes in energy substrate usage 

in response to acute stress in birds. B.H. Fokidis, R. Sparr, P. 

Deviche and K. Sweazea. Arizona State Univ. 

B93 849.5 Para-aminobenzoic acid is a coenzyme Q 

biosynthetic precursor in Saccharomyces cerevisiae. B.N. 

Marbois, S. Choi, T. Nguyen, K. Hyman, K. Hirano and C. 

Clarke. UCLA. 

B94 849.6 Effects of fatty acids on production of reactive 

oxygen species by skeletal muscle cells. R.T. Nachbar, A.D. 

Luchessi, T.D. Cambiaghi, R.H. Lambertucci, S.M. Hirabara, 

K.F. Vitzel, C.H. Pinheiro and R. Curi. Univ. of São Paulo. 

B95 849.7 17b-Estradiol inhibits isoproterenol activated 

lipolysis in murine adipocytes. N. Tagawa, S. Mitsumasu, R. 

Yuda and Y. Kobayashi. Kobe Pharmaceut. Univ., Japan. 

B96 849.8 Expression of human ADCK3 restores 

coenzyme Q biosynthesis and phosphorylation of Coq 

polypeptides in yeast abc1/coq8 mutants. L. Xie, E.J. Hsieh, S. 

Watanabe, C.M. Allan, U.C. Tran and C.F. Clarke. UCLA. 

Biochemistry 

850. Structure and Regulation of Lipid 

Transporters and Metabolizing 

Enzymes 

Poster 



B97 850.1 Endoplasmic reticulum stress enhances 

steroidogenic acute regulatory-related lipid transfer domain 

protein 5 expression and cholesterol efflux in HKC-8 human 

renal proximal tubule cells. B.J. Clark, Y. Chen, R. Brown, J.A. 

Carroll, K.M. Blaker, R.K. Meier, S.J. Khundmiri and E.D. 

Lederer. Univ. of Louisville and VA Med. Ctr. 

B98 850.2 Calcium regulation of group VIA calciumindependent 

phospholipase A2. Y-H. Hsu and E.A. Dennis. 

UCSD Sch. of Med. 

B99 850.3 A liver mitochondrial outer membrane fatty acid 

transfer complex. K. Lee, J. Kerner and C.L. Hoppel. Case 

Western Reserve Univ. 

B100 850.4 Fatty acid uptake in African trypanosomes. 

K.S. Paul, P. Vigueira, B. Winston, B. McCall, S. Cain, M. 

Ligon and J. McCallister. Clemson Univ. 

B101 850.5 Arachidonoyl substrate specificity of 

diacylglycerol kinases. Y. Shulga, M.K. Topham and R.M. 

Epand. McMaster Univ. Hlth. Sci. Ctr., Canada and Univ. of 

Utah. 

851. Tissue-Specific Regulation of Lipid 

Metabolism 

Poster 



B102 851.1 Adipose-specific deletion of SCD1 does not 

protect mice from obesity. M. Flowers, M. Strable, L. Ade, M. 

Zhao and J. Ntambi. Univ. of Wisconsin-Madison. 

B103 851.2 A comparative study of the lipid composition 

of the brain of chicken and rat during myelination: a 

chromatographic-densitometric analysis. F.M. Helmy and A. 

Morris. Delaware State Univ. 

B104 851.3 Hepatic oleate synthesis restores SREBP-1 

processing and lipogenesis in SCD1-deficient mice. M.S. 

Strable, X. Liu and J.M. Ntambi. Univ. of Wisconsin-Madison. 

852. Membrane Protein Synthesis, Insertion 

and Assembly 

Poster 



B105 852.1 Cotranslational regulation of calcium sensing 

receptor biosynthesis by an allosteric agonist. A. Cavanaugh 

and G.E. Breitwieser. Geisinger Clin., Danville, PA. 

B106 852.2 Protocadherin of the liver, kidney and colon 

associates with detergent-resistant membranes during cellular 

differentiation. S. Rizk, M.P. Krahn, M. Alfalah, M. Behrendt 

and H.Y. Naim. Lebanese American Univ., Beirut and Univ. of 

Vet. Med. Hannover. 

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853. Vesicular Trafficking 

Poster 



B107 853.1 Role of SNARE proteins in the pathogenesis of 

HIV. A. Achuthan, J.L. Zhou, S. Crowe and A. Jaworowski. 

Burnet Inst., Melbourne. 

B108 853.2 Downregulation of EGFR signaling requires 

Gas. A. Beas, A. Osipov and M.G. Farquhar. UCSD. 

B109 853.3 Biochemical and molecular confirmation of 

candidate endosome and vacuole interface (env) mutants 

derived from a genomic screen and characterization of four novel 

env deletion mutants: env6 - env9. S. Chhun, M. Serranilla, D. 

Olson, F. Ricarte, T. Soreta and E. Gharakhanian. California 

State Univ., Long Beach. 

B110 853.4 A novel vision to the process of ERpahgy in 

yeast. A-Y. Liu, K-H. Ho and W-P. Huang. Natl. Taiwan Univ. 

B111 853.5 Internalization of guanylyl cyclase/natriuretic 

peptide receptor-A occurs involving clathrin-dependent 

mechanisms. N.K. Somanna, A.C. Pandey, E. Wu, K.K. Arise 

and K.N. Pandey. Tulane Univ. Hlth. Sci. Ctr. 

B112 853.6 Clathrin binding to the DLLRKN region of 

huntingtin-interacting protein 1 requires coiled coil instability. 

J.A. Ybe, A. Alphonse Ignatius, D. Giedroc, M. Illingworth 

and S. Poorfarahani. Indiana Univ. 

854. Evolution and Development 

Poster 



B113 854.1 Nestling oral microbial colonization in tree 

swallows (Tachycineta bicolor). H.A. Danhof, P.A. Thorpe and 

M.P. Lombardo. Grand Valley State Univ. 

B114 854.2 Ribosomal protein sequence analysis reveals 

the order of evolution of bacterial classes, direct lineage 

of Cyanobacteria and chloroplasts and that LUCA was an 

Actinobacteria. W. Duax, R. Huether, D. Hogan, J. Teysir and 

D. Dziak. Hauptman-Woodward Inst., Buffalo. 

B115 854.3 Two members of the unusually large family of 

protein phosphatase 2B (PP2B, calcineurin) in paramecium 

have distinct roles in calcium dependent processes. D. 

Fraga, I. Sehring, R. Kissmehl, M. Reiss, R. Gaines and R. 

Hinrichsen. Col. of Wooster, Univ. of Konstanz, Germany and 

Indiana Univ. of Pennsylvania. 

B116 854.4 Possible immune functions of two mosquito 

multicopper oxidases. M. Lang, M.J. Gorman, S.G. Gardner, 

S.L. Yungeberg and M.R. Kanost. Kansas State Univ. and 

Agr. Univ. of Hebei, People’s Republic of China. 

B117 854.5 Investigating the molecular basis of 

temperature-dependent sex determination in the painted 

turtle. K.L. O’Shaughnessy, N. Valenzuela, J. Neuwald, R. 

Literman, A. Harris and T. Manternach. Capital Univ., OH, 

Iowa State Univ. and Hempstead H.S., Dubuque, IA. 

B118 854.6 Characterization of multicopper oxidase 

related protein in two insect species. Z. Peng, M.J. Gorman, Y. 

Arakane and M.R. Kanost. Kansas State Univ. 

855. G Proteins and Protein Kinases 

Poster 



B119 855.1 Regulator of G-protein signalling 4 KO mice 

show increased susceptibility to atrial fibrillation. C. Cifelli, K. 

Dissanayake, H. Zhang, J. Liu, S. Nattel, P.H. Backx and S. 

Heximer. Univ. of Toronto and McGill Univ. 

B120 855.2 Characterization of apical and basolateral 

PAR-2. C.S. Lau. Univ. of California, Riverside. 

B121 855.3 Does presynaptic GSK-3beta signaling play 

a role in bipolar disorder: studies of on dopamine transporter 

coding variants. L. Miller and R. Blakely. Vanderbilt Univ. 

B122 855.4 The nuclear protein chromodomain helicase 

binding protein 8 is a novel A-kinase anchoring protein. M.E. 

O’Donnell, M. Russell, L. Lund, Y. Zhang, R. Bloch and M. 

Bond. Univ. of Maryland Baltimore and Kent State Univ. 

B123 855.5 Structural analysis of the Gb1-CCT complex 

provides insight into the mechanism of Gb1 folding. R. 

Plimpton, C.W.J. Lai, K. Haines, C. Stowell, J. Cuellar, J. 

Martin-Benito, J.M. Valpuesta and B.M. Willardson. Brigham 

Young Univ. and Natl. Biotechnol. Ctr., Autonomous Univ. of 

Madrid. 

B124 855.6 Effect of TBT exposures on protein kinase D 

activity of human natural killer cells. K. Rana and M. Whalen. 

Tennessee State Univ. 

B125 855.7 Is b-arrestin-2 a determining factor in PARr-2 

stimulated allergic asthma H.L. Richards, E. Wilson and K. 

DeFea. Univ. of California, Riverside. 

B126 855.8 GRK2 activation by receptors. R. Sterne- 

Marr, A. Leahey, S.M. Amie, R. Donnelly, T.S. Lopez and J.J. 

Tesmer. Siena Col., NY and Univ. of Michigan. 

B127 855.9 Yeast kinome screen reveals a novel G-protein 

kinase. M.P. Torres, S.T. Westrick and H.G. Dohlman. Univ. of 

North Carolina at Chapel Hill. 

B128 855.10 VPAC1 signaling blocks Ikaros degradation by 

a PKA dependent mechanism in activated HuT-78 cells. T. Van 

der Steen, R. Hermann, K. Benton and G. Dorsam. North 


B129 855.11 Phosphorylation of Yin Yang 1 mediates 

fentanyl-induced decrease in miR-190 expression. H. Zheng, 

J. Chu, Y. Zeng, H.H. Loh and P-Y. Law. Univ. of Minnesota, 

Minneapolis. 

856. GTPases 

Poster 



B130 856.1 Characterization of GIV-Gai3, a non-receptor 

GEF-G protein complex involved in cell migration and 

metastasis. M. Garcia-Marcos, P. Ghosh, J. Ear and M.G. 

Farquhar. UCSD. 

262

tuesday 

857. Hormone Receptors 

Poster 



B131 857.1 Estrogen receptor-alpha expression in striatal 

tissue for future use in studying the effects of bisphenol A in the 

mammalian brain. K.J. Dickinson. Col. of Saint Benedict, St. 

John’s Univ., MN. 

B132 857.2 Measuring arrestin binding to G protein coupled 

receptors: BRET and recruitment assays tell different stories. 

L.E. Gimenez, G.J. Digby, C.D. Weaver, P.J. Conn and V.V. 

Gurevich. Vanderbilt Univ. Med. Ctr. 

B133 857.3 Binding-folding induced regulation of the 

glucocorticoid receptor AF1 transactivation domain by a cofactor 

that binds to its DNA binding domain. S.H. Khan, A.S. Garza, 

C.M. Moure, D.P. Edwards and R. Kumar. Commonwealth 

Med. Col., PA, Univ. of Texas Med. Branch and Baylor Col. of 

Med. 

B134 857.4 Postendocytotic trafficking of ETB receptors 

in cardiomyocytes: effects of pressure-overload hypertrophy 

on their subcellular distribution. C. Merlen, N. Farhat, L.R. 

Villeneuve, M-A. Gillis, E. Thorin and B.G. Allen. Montreal 

Heart Inst. and Univ. of Montreal. 

858. Peptide Hormones 

Poster 



B135 858.1 Decreased mineralization and lack of cyclin D1 

response to parathyroid hormone related peptide in primary 

osteoblasts isolated from MKP-1 knockout mice. N. Datta, B. 

Chaker and A. Abou-Samra. Wayne State Univ. Sch. of Med. 

B136 858.2 Estradiol regulates neuropeptidase activity 

in hypothalamic regions involved in regulating gonadotropinreleasing 

hormone. J.W. Qiao, N.E. Cyr, L.A. Bruce, M.J. Tetel 

and A.J. Wolfson. Wellesley Col. 

859. Posttranslational Modifications 

Poster 



B137 859.1 Deciphering the high mobility group proteins 

code. A. Beltran and B. Garcia. Hunter Col., CUNY and 

Princeton Univ. 

B138 859.2 Effects of high NaCl on cellular glutathione and 

glutathionylation of proteins in HeLa cells. S.K. Edwards, M.B. 

Burg and N.I. Dmitrieva. NHLBI, NIH. 

B139 859.3 Enzymology of DHHC-mediated protein 

palmitoylation. B.C. Jennings and M.E. Linder. Cornell Univ. 

and Washington Univ. in St. Louis. 

B140 859.4 Sumoylation impacts the transcriptional activity 

of Nrf2 and is necessary for its localization to promyelocytic 

leukemia nuclear bodies. M. Theodore, D. McIntosh, Y. Kawai 

and I.J. Arinze. Meharry Med. Col. 

Biochemistry 

860. Systems Biology, Synthetic Biology 

and Signal Transduction 

Poster 



B141 860.1 Nuclear import of RNA polymerase II requires 

the conserved GPN-loop GTPase XAB1/GPN1. A-A. Lacombe, 

D. Forget, P. Cloutier, R. Al-Khoury, A. Bouchard, M. Lavallee- 

Adam, C. Jeronimo, J. Archambault, M. Blanchette and B. 

Coulombe. Montreal Clin. Res. Inst., McGill Ctr. for Bioinformat. 

and Univ. of Montreal. 

B142 860.2 The importance of STAT6 regulated genes 

activated by type I interferon. H. Yu-An and W. Lei. Natl. Tsing 

Hua Univ. and China Med. Univ., Taiwan. 

861. Adapter Proteins 

Poster 



B143 861.1 A putative role for AHNAKk1 in maintaining 

gastric epithelial permeability barrier properties. A.A. Alli, G.M. 

Carter, D.M. Houyou, E.S. Routen and W.R. Gower, Jr. Univ. 

of South Florida and James A. Haley VA Hosp. 

B144 861.2 BS69 negatively regulates the canonical NFkB 

activation induced by Epstein-Barr virus-derived LMP1. O. 

Ikeda, Y. Sekine, R. Muromoto, A. Nanbo and T. Matsuda. 

Grad. Sch. of Pharmaceut. Sci. Hokkaido Univ., Japan. 

862. MAP Kinases 

Poster 



B145 862.1 Role of p44/42 activation in TBT-induced 

losses of granzyme B and perforin in human natural killer cells. 

A. Abraha and M. Whalen. Tennessee State Univ. 

B146 862.2 Tributyltin causes activation of the MAP3K, 

c-Raf, but not Ras in human natural killer cells. L. Celada and 

M. Whalen. Tennessee State Univ. 

B147 862.3 Effects of ziram on humman natural killer cell 

MAP kinases and cytolytic proteins. T.R. Taylor and M. Whalen. 

Tennessee State Univ. 

863. Phosphatases 

Poster 



B148 863.1 Protein phosphatase 1 controls function of 

Ikaros transcriptional factor and regulates chromatin remodeling 

during lymphocyte differentiation. S. Dovat, C. Song, Z. Gurel, 

K.J. Payne and M. Popescu. Univ. of Wisconsin-Madison and 

Loma Linda Univ. 

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B149 863.2 PPB is a novel serine/threonine phosphatase 

of Akt and is involved in myogenesis. X. Duan, S. Tao, X. Gao, 

J. Zhang, X. Lin and X-H. Feng. Baylor Col. of Med. and Johns 

Hopkins Univ. Sch. of Med. 

B150 863.3 Immunohistochemical and 

immunocytochemical localization of human phostensin. Y.S. 

Lin, T-F. Wang, H.C. Yu, R.S. Hung, K.Y. Huang, N.S. Lai 

and H.B. Huang. Natl. Chung Cheng Univ. and DaLin Tzu Chi 

Buddhist Hosp., Taiwan. 

B151 863.4 PHLPP phosphatase regulation of EGFR 

expression. M.J. Niederst, G. Reyes Cava, M. Kunkel and A. 

Newton. UCSD. 

B152 863.5 Deuterium exchange mass spectrometry 

reveals structural dynamics of glucan phosphatases. A. 

Sherwood and M. Gentry. Univ. of Kentucky Col. of Med. 

864. Protein Phosphorylation and 

Dephosphorylation 

Poster 



B153 864.1 Regulation of human cytidine triphosphate 

synthetase 2 by phosphorylation. D.R. Au, K.M. Kassel, M. 

Hines and L.M. Graves. Univ. of North Carolina at Chapel 

Hill. 

B154 864.2 Model for protein kinase A type RIa tetrameric 

holoenzyme. A.J. Boettcher, J. Wu, J. Yang, N. Cheung, A.P. 

Kornev, C. Kim and S.S. Taylor. UCSD and HHMI, La Jolla. 

B155 864.3 Defining the conserved internal architecture 

of a protein kinase. A.P. Kornev and S.S. Taylor. HHMI and 

UCSD. 

B156 864.4 Effects of site-specific phosphorylation on the 

structure and functions of the intrinsically disordered N-terminal 

activation function (AF1) domain of the glucocorticoid receptor. 

R. Kumar, A.S. Garza and S.H. Khan. Commonwealth Med. 

Col., PA and Univ. of Texas Med. Branch. 

B157 864.5 An inhibitor against CKII phosphorylation 

downregulates VPAC1 expression in HuT-78 cells. A.M. Nelson, 

K.D. Benton, R. Hermann, T. Van der Steen and G. Dorsam. 


B158 864.6 Small molecule inhibitors of PHLPP determined 

by chemical and virtual screening. E. Sierecki, W. Sinko, J.A. 

McCammon and A.C. Newton. UCSD. 

B159 864.7 Characterization of a putative AS regulatory 

phosphorylation site implicated in vascular endothelial nitric 

oxide production. R. Thompson, K.D. Corbin, L.C. Pendleton 

and D.C. Eichler. Univ. of South Florida and Univ. of North 

Carolina at Chapel Hill, Kannapolis. 

865. Receptor Tyrosine Kinase Signaling to 

Nucleus 

Poster 



B160 865.1 The nerve growth factor receptor TrkA exists as 

a pre-formed homodimer before ligand binding. J. Shen and I. 

Maruyama. Okinawa Inst. of Sci. and Technol. 

866. Serine/Threonine Kinase 

Poster 




B161 866.1 Investigation of Rho-associated kinase 

phosphorylation of carboxyl terminus of the sodium hydrogen 

exchanger isoform 1. D.J. Hammes, A. Slusser, J.B. Shabb, 

W.W. Muhonen, M.A. Wallert and J.J. Provost. Minnesota 

State Univ. Moorhead and Univ. of North Dakota Sch. of Med. 

and Hlth. Sci. 

B162 866.2 Involvement of protein kinase Ca in invadopodia 

formation in Src-3T3 cells. A.K. O’Neill, L.L. Gallegos and 

A.C. Newton. UCSD and Harvard Med. Sch. 

B163 866.3 Structure of D-AKAP2-PKA RI isoform complex: 

insights into AKAP specificity and selectivity. G.N. Sarma, F.S. 

Kinderman, S. von Daake and S.S. Taylor. UCSD. 

B164 866.4 Consequences of activation loop 

phosphorylation on protein kinase A. J.M. Steichen, G.H. Iyer, 

S. Li, V.L. Woods and S.S. Taylor. UCSD, Vertex Pharmaceut., 

Cambridge, MA and HHMI, La Jolla. 

867. Small GTPases 

Poster 



B165 867.1 Identifying the essential arginine required for 

ELMOD1 GAP activity. J.R. Fritz, M.P. East and R.A. Kahn. 

Emory Univ. 

B166 867.2 GIT1 act as GAP for Arf6 downstream integrin 

outside-in signaling during platelet aggregation. Y. Huang and 

W. Sidney. Univ. of Kentucky Col. of Med. 

B167 867.3 Electrophysiological abnormalities in mice with 

genetic ablation of Rap1a GTPase. S.C. Jeyaraj, M.S. Joshi, H. 

Huang, N.T. Unger, N.P. El-Dahdah, L.E. Wold, A.R. Strauch, 

T.S. Elton, L.A. Quilliam, J.A. Bauer and M.A. Chotani. 

Nationwide Children’s Hosp., Davis Heart & Lung Res. Inst., 

Columbus and Indiana Univ. Sch. of Med. 

B168 867.4 Allosteric modulation of Ras: a novel role for 

glutamine 61 in catalysis. C. Mattos, G. Buhrman, S. Fetics 

and G. Holzapfel. North Carolina State Univ. 

B169 867.5 Cholecystokinin-induced PKC a activation 

mediates the translocation of RhoA in mouse pancreatic acini. 

M.E. Sabbatini and J.A. Williams. Univ. of Michigan. 

B170 867.6 Rho signaling is involved in HIV-1 tat-induced 

tight junction protein ZO-1 translocation and alterations of 

claudin-5 expression in brain endothelial cells. Y. Zhong, B. 

Hennig and M. Toborek. Univ. of Kentucky. 

868. Tyrosine Kinases 

Poster 



B171 868.1 Requirement of c-Src in angiotensin II and 

endothelin 1-induced activation of MAP kinases in vascular 

smooth muscle cells. G. Vardatsikos, G. Kapakos and A.K. 

Srivastava. Univ. of Montreal and Univ. of Montreal Hosp. Ctr. 

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Biochemistry 

869. Calcium 

Poster 



B172 869.1 Role of calcium in the structure and function of 

protocadherin of the liver, kidney and colon. M. Behrendt, M.P. 

Krahn, S. Rizk, M. Alfalah and H.Y. Naim. Univ. of Vet. Med. 

Hannover. 

B173 869.2 Agonist-induced Ca 2+ mobilization is regulated 

by a complex involving Orai1, hTRPC3 and the type I inositol 

1,4,5-trisphosphate receptor. I. Jardin, G.E. Woodard, J.J. 

Lopez, G.M. Salido and J.A. Rosado. Univ. of Extremadura, 

Spain and NIDDK, NIH. 

B174 869.3 Binding of STIM1, but not Orai1 to TRPC4 

activates store-operated calcium entry in mouse lung 

endothelial cells. P. Sundivakkam, M. Freichel, I. Levitan, 

S.M. Vogel, V. Flockerzi, A.B. Malik and C. Tiruppathi. Univ. 

of Illinois at Chicago and Univ. des Saarlandes, Germany. 

870. Cyclic AMP 

Poster 



B175 870.1 Analysis of cyclic AMP-coupled signature 

molecules in human microvascular smooth muscle cells shows 

link to stress-associated proteins. S.C. Jeyaraj, N.T. Unger, N.P. 

El-Dahdah, R.J. Sessler, M. Zirwas, A. Pleister, K.B. Green- 

Church and M.A. Chotani. Nationwide Children’s Hosp. and 

Ohio State Univ. 

871. Nitric Oxide 

Poster 



B176 871.1 Stimulation of GTP cyclohydrolase I by 

phosphorylation upon T cell activation. W. Chen, L. Li, T. Brod, 

O. Saeed, S. Dikalov and D.G. Harrison. Emory Univ. 

B177 871.2 Heterologous expression of microbial 

flavohemoglobin can modulate the effects of nitric oxide in 

mammalian cells. C.E. Eyler, M.T. Forrester, A.B. Hjelmeland 

and J.N. Rich. Duke Univ. and Cleveland Clin. 

B178 871.3 Monitoring GTPCH-1 interaction with GFRP 

using time-resolved fluorescence resonance energy transfer. 

L. Li, Y. Du, H. Fu, J.C. Salerno, W. Chen and D.G. Harrison. 

Emory Univ. Sch. of Med. and Kennesaw State Univ., GA. 

B179 871.4 Conformational effects induced by YC-1 and 

carbon monoxide binding to soluble guanylate cyclase. I. Lopez- 

Pena, J. Kristianto, N. Counts Gerber and R. Esquerra. San 

Francisco State Univ. 

B180 871.5 Insulin coordinately regulates nitric oxide 

synthase and argininosuccinate synthase to maintain vascular 

endothelial function. L.C. Pendleton, R.J. Thompson, K.D. 

Corbin, C.J. Meininger and D.C. Eichler. Univ. of South 

Florida, Univ. of North Carolina at Chapel Hill, Kannapolis and 

Texas A&M Hlth. Sci. Ctr., Temple. 

872. Phosphodiesterases 

Poster 



B181 872.1 S-adenosylmethionine downregulates 

phosphodieterease 4B expression and attenuates endotoxininduced 

TNF expression in monocytes via cAMP/PKA pathway. 

L. Gobejishvili, S. Barve, I. Kirpich, D. Avila, S. Joshi-Barve 

and C. McClain. Univ. of Louisville. 

873. Second Messengers 

Poster 



B182 873.1 Diacylglycerol production at the Golgi: 

regulation by Ca 2+ . M. Kunkel and A. Newton. UCSD. 

874. The 3Rs, Genome Instability, and Disease 

Poster 



B183 874.1 DNA breaks at fragile sites generate oncogenic 

RET/PTC rearrangements in human thyroid cells. L. Dillon, 

M. Gandhi, S. Pramanik, L. Pierce, Y. Nikiforov and Y-H. 

Wang. Wake Forest Univ. Sch. of Med., Univ. of Pittsburgh and 

UCSD. 

B184 874.2 Role of base pairing partner on DNA-protein 

crosslinking from guanine oxidation. Z.A. Perez, A. Madison 

and E.D.A. Stemp. Mount St. Mary’s Col., CA. 

B185 874.3 Enhanced level of genome instability 1 has 

an essential role in early development and suppressing 

tumorigenesis. N. Sikdar and K. Myung. NHGRI, NIH. 

875. DNA Damage Signaling and Repair 

Poster 



B186 875.1 Ku and DNA-PK dynamic conformations and 

assembly regulate DNA binding and the initial NHEJ complex. 

M. Hammel. Lawrence Berkeley Natl. Lab. 

B187 875.2 Phosphorylation of RPA2 is required for 

TopBP1 recruitment and ATR activation. S. Liu, J. Glanzer and 

G. Oakley. Univ. of Nebraska Med. Ctr., Lincoln. 

B188 875.3 Elucidating the role of the DNA helicase Pfh1 in 

DNA repair in fission yeast. K.E. McMurdie, J. Little, J. Sielge 

and S. Dunaway. Drew Univ. 

B189 875.4 Evidence for multiple active forms of the DNA 

damage response protein UmuD. J.N. Ollivierre, A. Wallace 

and P.J. Beuning. Northeastern Univ. 

B190 875.5 Role of Dps1 and Dps2 in reactive oxygen 

species tolerance in Deinococcus radiodurans. B.J. Reon and 

A. Grove. LSU. 

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876. DNA Repair Mechanisms 

Poster 



B191 876.1 Defining the interaction between the 

Escherichia coli RecA and DinI proteins. L.B. Bane, R.L. Britt, 

M.M. Cox and E.H. Egelman. Univ. of Wisconsin-Madison and 

Univ. of Virginia. 

B192 876.2 Developing reporter systems to monitor the 

structural dynamics of MutS. C.W. Doucette and F.N. Biro. 

Wesleyan Univ. 

B193 876.3 Induction of DNA damage repair defect by the 

exogenous expression of BRCA2 BRC repeat in Trypanosoma 

bruce. M. Hall III, S. Misra, M. Chaudhuri and G. Chaudhuri. 

Meharry Med. Col. 

B194 876.4 Human DNA glycosylase NEIL1 but not NEIL2 

preferentially collaborates with proteins of DNA replication to 

carry out LP-BER in replicating cells. M.L. Hegde, P.M. Hegde, 

C.A. Theriot, A.A. Tomkinson, G-M. Li, T.K. Hazra and S. 

Mitra. Univ. of Texas Med. Branch, Univ. of Maryland Sch. of 

Med. and Univ. of Kentucky Col. of Med. 

B195 876.5 A sliding scale governs mismatch recognition 

and initiation of DNA mismatch repair. M. Hingorani and J. 

Zhai. Wesleyan Univ. 

B196 876.6 NMR study of the effect of Zn on conformational 

activation of rat DNA polymerase b. T.W. Kirby, W.A. Beard, 

S.H. Wilson and R.E. London. NIEHS, NIH, Research Triangle 

Park. 

B197 876.7 Evidence that nucleosomes inhibit mismatch 

repair in eukaryotic cells. F. Li, L. Tian, L. Gu and G-M. Li. 


B198 876.8 Role of a strictly conserved residue in 

N-glycosylic bond cleavage by human thymine DNA glycosylase. 

A. Maiti and A.C. Drohat. Univ. of Maryland Sch. of Med. and 

Greenebaum Cancer Ctr. 

B199 876.9 PCNA phosphorylation at tyrosine211 inhibits 

mismatch repair at the initiation step. J. Ortega, T. Zhang, J. 

Huang, G-M. Li and L. Gu. Univ. of Kentucky and Wuhan Univ., 

People’s Republic of China. 

B200 876.10 Saccharomyces cerevisiae mismatch repair 

complex MLH1-PMS1 binds and rapidly diffuses along DNA 

in one dimension. A.J. Plys, J. Gorman, M-L. Visnapuu, E. 

Greene and E. Alani. 

B201 876.11 Interactions of yeast HMO2 with distorted DNA. 

W. Rahman, S. Ray and A. Grove. LSU. 

B202 876.12 High mobility group protein HMO2 promotes 3′ 

and 5′- homologous strand invasion in yeast. S. Ray and A. 

Grove. LSU. 

B203 876.13 Role of cooperative ATP hydrolysis in RecA 

protein filaments. R.M. Reyes, M.C. Gruenig and M.M. Cox. 

Univ. of Wisconsin-Madison. 

B204 876.14 Effects of the antioxidants in pomegranate 

juice on DNA-protein crosslinking via guanine oxidation. K. 

Rodgers, L. Marzvanyan, A. Madison and E. Stemp. Mount 

St. Mary’s Col., CA. 

B205 876.15 Structural insights into DNA polymerase X from 

African swine fever virus in the presence of oxoG lesions. B.A. 

Sampoli Benitez, K. Arora, J. Bogdanovic and T. Schlick. 

Marymount Manhattan Col., Univ. of Michigan and NYU. 


B206 876.16 Processing of various sizes of (CAG)n/(CTG)n 

hairpins in human nuclear extracts. T. Zhang, J. Huang, L.G. 

Gu and G-M. Li. Wuhan Univ., People’s Republic of China and 


877. Genome Diversity and DNA 

Recombination 

Poster 



B207 877.1 An evolutionary and functional analysis of 

vibrio pathogenicity island 2. M.G. Napolitano, S. Almagro- 

Moreno and F. Boyd. Univ. of Delaware. 

B208 877.2 Analysis of genetic variation between wild and 

mutant strains of hyper-pectinolytic Aspergillus niger using 

RAPD-PCR. U.A. Okafor, V.I. Okochi, O.A.O. Ebuehi, J. 

Okpuzor and A.A. Adekunle. Univ. of Lagos, Idi Araba and 

Akoka, Nigeria. 

B209 877.3 Characterization of the functional domains of 

TnsC. J.M. Spencer and N.L. Craig. Johns Hopkins Sch. of 

Med. and HHHMI, Baltimore. 

B210 877.4 Maturational alteration of differential 

expressions of GC:AT-biased genotypes of Cordyceps sinensis 

fungi and Paecilomyces hepiali in Cordyceps sinensis. J-S. 

Zhu, L. Gao, Y. Yao and Y. Zhou. Pharmanex Res. Inst., Provo, 

Sch. of Pharm., Shihezi Univ., People’s Republic of China and 

Pharmanex Beijing Pharmacol. Ctr. 

878. Genome Stability and DNA Repair 

Poster 



B211 878.1 Age-dependent accumulation of mitochondrial 

DNA damage in brain tissues derived from Apex1 +/- mice. K. 

Acevedo-Torres, C.A. Torres-Ramos, C.A. Walter and S. 

Ayala-Torres. San Juan Bautista Sch. of Med., PR, Univ. of 

Puerto Rico Med. Sci. Campus, Univ. of Texas Hlth. Sci. Ctr. at 

San Antonio and South Texas Veteran’s Hlth. Care Syst. 

B212 878.2 Computational prediction and experimental 

validation of 5 DNA-binding residues of human flap 

endonuclease 1. J. Kanjanapangka, L.D. Finger, Jr. and B. 

Shen. City of Hope, Duarte. 

B213 878.3 Increased DNA damage and decreased DNA 

repair following poly(ADP-ribose) glycohydrolase inhibition and 

chemotherapy. D.W. Koh, Y. Zhou, X. Feng and K.D. Garcia. 

Washington State Univ. 

B214 878.4 A role for Np95 in genome integrity maintenance. 

H.S. Mistry. Univ. of Toronto. 

B215 878.5 Influence of Werner helicase deficiency on 

nonhomologous end-joining in human cells. K. Smith and A.S. 

Waldman. Univ. of South Carolina. 

B216 878.6 Transcription arrest at G quadruplex DNAforming 

sequences. S. Tornaletti, J.S. Beckett and C. 

Broxson. Univ. of Florida. 

B217 878.7 Apex1 haploinsufficiency leads to agedependent 

increases in mtDNA lesions in liver. C.A. Torres- 

Ramos, C. Torres-Ortíz, C.A. Walter and S. Ayala-Torres. 

Univ. of Puerto Rico Med. Sci. Campus, Univ. of Texas Hlth. Sci. 

Ctr. at San Antonio and South Texas Veteran’s Hlth. Care Syst. 

266

tuesday 

B218 878.8 Role of sororin in sister chromatid cohesion 

and separation in vertebrates. N. Zhang, A.K. Panigrahi, Y. 

Jiang, P.H. Rao and D. Pati. Baylor Col. of Med. 

879. Mechanism of DNA Recombination 

Poster 



B219 879.1 The N-terminal domain of BLM/Sgs1 displays a 

strand-annealing and strand-exchange activity that is required 

for in vivo function. C-F. Chen and S. Brill. Rutgers Univ., 

Piscataway. 

B220 879.2 microRNA analysis of the role of RecA2 in 

plant mitochondrial DNA replication in A. thaliana. A.N. Wright 

and J. Cupp. Brigham Young Univ. 

880. Signaling Responses to DNA Damage 

Poster 



B221 880.1 CpG-DNA protects against UV-induced 

apoptosis via enhancement of AKT and mTORC1 in 

keratinocytes and dendritic cells. S. Lu, C. Cao, R. Kivlin, S. 

Sarkisian, J. Parisi, M. McCauley, A. Nalbandian, G. Brum, 

A. Xu, W-m. Chu, J. Marshall and Y. Wan. Providence Col., 

Brown Univ. and The 3rd Hosp. of Hangzhou, People’s Republic 

of China. 

B222 880.2 DNA damage response protein UmuD displays 

conformational dynamics. J.L. Sikora, J.N. Ollivierre, D.E. 

Budil and P.J. Beuning. Northeastern Univ. 

881. Alternative splicing 

Poster 



B223 881.1 Alternative splicing of Kruppel-like factor 4 

plays a pivotal role in human tumorigenesis. J.H. Bahn, S-H. 

Lee and S.J. Baek. Univ. of Tennessee, Knoxville. 

B224 881.2 Analyses of alternative splicing in C. elegans 

longevity genes. R.L. Seipelt, L. Saites, V. Mohan and A. 

Winfrey. Middle Tennessee State Univ. 

882. Ribozyme Structure and Catalysis 

Poster 



B225 882.1 Annotation and structural modeling of 

Anabaena group I ribozyme variants. E. Bow, H. Koaches and 

C. Rohlman. Albion Col., MI. 

B226 882.2 Toward the isolation of a novel RNA-RNA 

interaction based on an activity of a trans-acting ribozyme. J. 

Ishikawa, H. Furuta and Y. Ikawa. Kyushu Univ., Japan and 

PRESTO, JST, Tokyo. 

Biochemistry 

B227 882.3 In vivo selection of mRNA repair ribozymes 

from randomized pools. U.F. Müller and K.E. Olson. UCSD. 

B228 882.4 Minimization and refinement of hepatitis delta 

virus-like ribozyme secondary structure descriptors. N.J. 

Riccitelli and A. Luptak. Univ. of California, Irvine. 

B229 882.5 Fluorescent-based assay for group I ribozymes 

using an ABI 310 genetic analyzer. T. Stevens and C. Rohlman. 

Albion Col., MI. 

B230 882.6 An all RNA hypercyclic network. N. Vaidya and 

N. Lehman. Portland State Univ. 

B231 882.7 Discovering HDV/CPEB3-like ribozymes. 

C-H.T. Webb, N.J. Riccitelli, D.J. Ruminski and A. Lupták. 

Univ. of California, Irvine. 

B232 882.8 Fluorophore optimization for FRET-based 

ribozyme studies. M. Zaborowicz and C. Rohlman. Albion 

Col., MI. 

883. RNA Folding 

Poster 



B233 883.1 Knot your average RNA: the Chlorella virus 

pyrimidine dimer-specific glycosylase intron. B.C. Larson, A.S. 

Burton and N. Lehman. Portland State Univ. 

884. RNA Processing 

Poster 



B234 884.1 Evolution of new exons and alternative splicing 

in primates. L. Lin, S. Shen, P. Jiang, S. Sato, B.L. Davidson 

and Y. Xing. Univ. of Iowa. 

B235 884.2 Analysis of the structure and function of a 

forkhead-associated domain-containing gene, DAWDLE, 

in Arabidopsis thaliana. L.A. Narayanan and D. Chevalier. 

Mississippi State Univ. 

B236 884.3 Optimizing conditions for cleavage of pre-tRNA- 

Gln(CAA) by Haloferax volcanii tRNA intron endonuclease. K. 

Tellings, C. Salva, M.E. Ginn-Pease and J.M. Hemmingsen. 

Capital Univ. 

885. RNA Structure and Dynamics 

Poster 



B237 885.1 In vitro selection of novel classes of GNRA 

tetraloop receptors. E.R. Calkins, V. Keleshian and L. Jaeger. 

Univ. of California, Santa Barbara. 

B238 885.2 Murine leukemia virus pseudoknot: structural 

analysis of conformational changes. C. Salguero, V. D’Souza 

and M. Durney. Hunter Col., CUNY and Harvard Univ. 

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886. RNA Therapeutics 

Poster 



B239 886.1 Nucleic acid nanocapsules: packaging mRNA 

into the vault particle. M. Pupols, V.A. Kickhoefer and L.H. 

Rome. UCLA. 

887. Splicing Mechanism and Regulation 

Poster 



B240 887.1 Mechanisms involved in efficient removal of 

multiple introns. T.L. Crabb, B.J. Lam and K.J. Hertel. Univ. of 

California, Irvine and The Scripps Res. Inst. 

B241 887.2 Insulin signaling via PKCD isoforms in the 

diabetic brain promotes cognitive function. N.A. Patel and D.R. 

Cooper. James A. Haley VA Hosp. and Univ. of South Florida. 

B242 887.3 Analysis of ESTs for alternatively spliced 3’ 

and 5’ splice sites reveals optimal exon size in vertebrates. P.J. 

Shepard and K.J. Hertel. Univ. of California, Irvine. 

B243 887.4 Postnatal AFP repression by Zhx2 through 

RNA splicing inhibition. L. Turcios, B. Spear and M. Peterson. 


888. Aging and Metabolism 

Poster 



B244 888.1 The role of wnt-10b in osteoblast development. 

J.A. Chase, U. Moedder, D. Monroe and S. Khosla. South 

Dakota State Univ. and Mayo Clin. 

B245 888.2 The influence of dietary lipids on mitochondrial 

hydrogen peroxide production in liver of calorie restricted mice. 

Y. Chen, K. Domer, K. Hagopian and J. Ramsey. Univ. of 

California, Davis. 

B246 888.3 Multi-analyte profiling reveals MCP-1 and 

MMP-9 as plasma biomarkers of cardiac aging. Y.A. Chiao, Y. 

Jin, Q. Dai, Y-M. Chou and M.L. Lindsey. Univ. of Texas Hlth. 

Sci. Ctr. at San Antonio and Univ. of Texas at San Antonio. 

B247 888.4 Using thermotolerance to explore differences in 

Caenorhabditis elegans diet. L. Lee, F. Gomez, C. Srinivasan 

and C.F. Clarke. California State Univ., Fullerton and UCLA. 

B248 888.5 The effects of diet cycling on longevity. E.O. 

List, J. Wright-Piekarski, D.E. Berryman and J.J. Kopchick. 

Ohio Univ. 

B249 888.6 Metabolic signaling in aging and disease. L. 

Pilgeram. Univ. of California, Santa Barbara. 

B250 888.7 The effect of p66 Shc on energy expenditure 

in mice. J.H. Stern, K. Hagopian, R.B. McDonald and J.J. 

Ramsey. Univ. of California, Davis. 

889. Metabolism and Disease 

Poster 



B251 889.1 Fluxome analysis of C13-pyruvate reveals 

differential metabolic responses between heart, liver and red 

blood cells following endotoxemia. R.M. Bateman, Y. Nagahata, 

M. Ohmura, T. Hishiki and M. Suematsu. Keio Univ., Japan. 

B252 889.2 Reduced milk triglycerides in mice lacking 

phosphoenolpyruvate carboxykinase in mammary gland 

adipocytes and white adipose tissue contribute to the 

development of insulin resistance in pups. C.M. Croniger, C-W. 

Hsieh, C.A. Millward, D. DeSantis, S. Pisano, J. Machova 

and J.C. Perales. Case Western Reserve Univ. and Univ. of 

Barcelona. 

B253 889.3 Molecular mechanism of RBP4 on the basis of 

insulin signaling pathway in primary hepatocytes. J. Namkung, 

M.Y. Kim, M.K. Woo, J.H. Sohn, S.W. An and B-I. Yeh. Wonju 

Col. of Med., Yonsei Univ., Republic of Korea. 

B254 889.4 Cold treatment does not increase the rate of 

platelet clearance in 13-lined ground squirrels. K.E. Richters, 

R. Benrud, P. Hordyk and S. Cooper. Univ. of Wisconsin-La 

Crosse. 

B255 889.5 Vitamin A and vitamin E levels in lung from 

subjects with chronic obstructive pulmonary disease with 

different degree of severity of emphysema. M.W. Schäffer, S. 

Sinha Roy and S.K. Das. Meharry Med. Col. 

B256 889.6 Impact of intracellular glycosylation on the prosurvival 

role of insulin. C-F. Teo, E.G. El-Karim and L. Wells. 

Univ. of Georgia. 

B257 889.7 Biochemical-structural-phenotypic correlation 

of adenylosuccinate lyase deficiency based on analysis of 

mutant enzyme complexes. M. Zikanova, V. Skopova, A. 

Hnizda, J. Krijt and S. Kmoch. First Fac. of Med., Charles 

Univ. in Prague. 

890. Metabolism and Epigenetics 

Poster 



B258 890.1 DNA methyltransferases in male offspring of 

sleep-deprived mice. B.F.A. Calegare, L. Fernandes, S. Tufik 

and V. D’Almeida. UNIFESP, São Paulo. 

B259 890.2 Phosphorylation of Thr522 activates SIRT1 

and is required for DYRK-mediated cell survival in response 

to DNA damage. X. Li, X. Guo, J. Williams and R. Bienstock. 

NIEHS, NIH, Research Triangle Park. 

B260 890.3 Epigenetic marks of nuclear-encoded 

mitochondrial genes by DNA methylation. M. Takasugi, K. 

Hirabayashi, S. Yagi and K. Shiota. Univ. of Tokyo. 

B261 890.4 Dot1a-AF9-AF17-mediated transcriptional 

changes in the epithelial sodium channel (ENaC) are translated 

into changes in ENaC-mediated Na + transport. W. Zhang. Univ. 

of Texas Med. Sch. at Houston. 

268

tuesday 

Biochemistry 

891. Metabolism and Neurodegeneration 

Poster 



B262 891.1 Effects of 2-chloroethyl ethyl sulfide on guinea 

pig brain morphology. J. Gadsden-Gray, S. Mukherjee, O. 

Ogunkua and S.K. Das. Meharry Med. Col. 

B263 891.2 The role of methionine cycle metabolites in 

autoimmune neurodegenerative diseases. L.A. Gardner, 

A.M. Hartzes, D. Clark, E. Gotuzzo and M.C. Levin. Univ. of 

Tennessee Hlth. Sci. Ctr. and VA Med. Ctr., Memphis and Inst. 

Of Trop. Med. Alexander von Humboldt, Lima, Peru. 

B264 891.3 Understanding molecular mechanisms in 

mitochondria underlying LRRK2-related Parkinson’s disease. 

H. Liu, W.L. Ho, W.M. Ho, Z.J. Zhou and S.L. Ho. Univ. of Hong 

Kong. 

B265 891.4 Enhanced expression of Glia maturation factor 

in Alzheimer’s disease. A. Zaheer, S. Zaheer, R. Thangavel, L. 

Ramamoorthy, X. Yang and S.K. Sahu. VA Med. Ctr. and Univ. 

of Iowa. 

892. Metabolism and Nutrition 

Poster 



B266 892.1 Mitochondrial de novo thymidylate biosynthesis. 

D.D. Anderson, C.M. Quintero and P.J. Stover. Cornell Univ. 

B267 892.2 Calcium levulinate: dietary supplement and 

pro-drug of abuse. S.R. Anderson, G-F. Zhang, A.M. Murphy, 

K.A. Tomcik and H. Brunengraber. Case Western Reserve 

Univ. 

B268 892.3 Myo-inositol synthesis in Drosophila 

melanogaster effects development. G.D. Batugedara, T-V. Ho, 

N.A. Jackson, A. Ugarte, A.J.R. Carter, E.D. Eldon and L.S. 

Klig. California State Univ., Long Beach. 

B269 892.4 Dysregulation of lipolysis and lipid metabolism 

in visceral and subcutaneous adipocytes by high-fat diet. R.B. 

Ceddia, N.M. Anthony, P. Patel, F. Noor, T.J. Hawke and 

M.P. Gaidhu. Sch. of Kinesiol. and Hlth. Sci., York Univ. and 

McMaster Univ., Canada. 

B270 892.5 Regulation of de novo thymidylate biosynthesis 

by ubiquitination. J.Y. Eom, D.D. Anderson and P.J. Stover. 

Cornell Univ. 

B271 892.6 Robotic high throughput fatty acid analysis of 

umbilical cord serum. Y. Lin, J.R. Hibbeln, W. Zhou, J. Loewke, 

J.A. Brown, W.E.M. Lands, E.M. Wells, L.R. Goldman and N. 

Salem, Jr. NIAAA, NIH, Case Western Reserve Univ. Sch. of 

Med. and Johns Hopkins Univ. Bloomberg Sch. of Publ. Hlth. 

893. Metabolism and Signaling 

Poster 



B272 893.1 Role of 4-hydroxynonenal in oxidative stressinduced 

signaling. P. Chaudhary, R. Sharma, A. Sharma, R. 

Vatsyayan, S. Yadav, M. Hadley, S. Awasthi and Y.C. Awasthi. 

Univ. of North Texas Hlth. Sci. Ctr. 

B273 893.2 Exploring signaling events surrounding 

extracellular amastigote invasion processes of Trypanosoma 

cruzi. E.R. Ferreira, E.A. Silva, R.W. Costa, M.C. Cruz, M.C. 

Fernandes, R.A. Mortara and D. Bahia. Paulista Sch. of Med.- 

UNIFESP, São Paulo and Univ. of Maryland College Park. 

B274 893.3 Oltipraz inhibits liver X receptor-alphadependent 

lipogenic gene induction and hepatic steatosis via 

AMPK-S6K1 pathway. S.G. Kim, S.H. Hwang, S.H. Ki, E.J. 

Bae and H.E. Kim. Col. of Pharm., Seoul Natl. Univ. 

B275 893.4 Akt1 and Akt2 exhibit isoform-specific functions 

in HL-1 cardiomyocytes. A. Raupach, S.L. Möllendorf and A. 

Gödecke. Heinrich Heine Univ. Düsseldorf. 

B276 893.5 Postnatal rosiglitazone administration to 

neonatal rat pups does not alter the adult metabolic phenotype. 

V.K. Rehan, N. Truong, R. Sakurai, W-N.P. Lee and J.S. 

Torday. LA BioMed, Torrance. 

B277 893.6 Retinoid metabolism and signaling in lung from 

COPD patients with different degree of emphysema. S. Sinha 

Roy, M.W. Schäffer, D.E. Ong and S.K. Das. Meharry Med. 

Col. and Vanderbilt Univ. 

B278 893.7 Metadoxine, an ion-pair of pyridoxine and L-2- 

pyrrolidone-5-carboxylate, inhibits adipocyte differentiation 

through its repression of PKA-dependent CREB activity. Y.M. 

Yang, H.E. Kim, S.H. Ki and S.G. Kim. Col. of Pharm., Seoul 

Natl. Univ. 

894. Nutrient Regulation of Signaling and 

Transcription 

Poster 



B279 894.1 Divalent metal-dependent regulation of 

hepcidin expression by MTF-1. S. Balesaria, H. Bayele and K. 

Srai. University Col. London. 

B280 894.2 Repressive effect of polyunsaturated fatty 

acids on serine dehydratase expression in rat hepatocytes. 

A. Contreras, V. Ortiz, N. Torres and A.R. Tovar. Natl. 

Autonomous Univ. of Mexico and Natl. Inst. of Med. Sci. and 

Nutr. Salvador Zubirán , Mexico City. 

B281 894.3 Distinct phosphatase requirements and 

GATA factor responses to nitrogen catabolite repression and 

rapamycin treatment in S. cerevisiae. T.G. Cooper, J.J. Tate, I. 

Georis and E. Dubois. Univ. of Tennessee, Memphis and Inst. 

of Microbiol. Res. J-M. Wiame, Brussels. 

B282 894.4 Selected beta-apocarotenoids antagonize 

retinoic acid-induced transactivation of retinoic acid receptors. 

A. Eroglu, D. Hruszkewycz, R.W. Curley and E.H. Harrison. 

Ohio State Univ. 

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iochemistry 

B283 894.5 Selenium-dependent expression of 

hematopoietic prostaglandin D synthase in macrophages. U.H. 

Gandhi, N. Kaushal and K.S. Prabhu. Penn State. 

B284 894.6 Regulation of arginase-I expression in 

macrophages by selenium. S.M. Nelson, U.H. Gandhi, N. 

Kaushal and K.S. Prabhu. Penn State. 

B285 894.7 Alpha-keto acid metabolites of organoselenium 

compounds inhibit HDAC activity. H. Nian and R.H. Dashwood. 

Oregon State Univ. 

895. Cell Migration 

Poster 



B286 895.1 Investigating mechanisms that mediate 

cyclooxygenase-2 signaling in colon cancer development. 

R.R. Bean, K.L. Harpster, K.M. Hessel, R. Jakobi and Y-W.E. 

Chang. Kansas City Univ. of Med. and Biosci., MO. 

B287 895.2 The actin binding protein cortactin is 

overexpressed in metastatic cancer cells. S. Click and A.E. 

Kruchten. Linfield Col., OR. 

B288 895.3 Promoting dendritic cell migration by airway 

epithelial cells through interleukin-17A-induced CCL20 

expression. L.Y. Hung, F. Huang, T.T. Nguyen and R. Wu. 

Univ. of California, Davis. 

B289 895.4 Imidazole inhibits B16 melanoma cell migration 

via degradation of beta-catenin. Y.M. Jeong, H.L. Li, S.Y. Kim, 

H-Y. Yun, K.J. Baek, N.S. Kwon and D-S. Kim. Chung-ang 

university, Republic of Korea. 

B290 895.5 C. elegans homolog of tailless regulates male 

gonadal migration. M. Kato and P. Sternberg. Caltech and 

HHMI. 

B291 895.6 Role of mDia1 in RAGE signaling and smooth 

muscle cell migration. F. Toure, G. Fritz, Q. Li, J. Peng, Y. Lu, 

R. Rosario, S.F. Yan, A. Alberts, R. Ramasamy and A.M. 

Schmidt. Columbia Univ., Univ. of Kontanz, Germany and Van 

Andel Inst., Grand Rapids. 

B292 895.7 Tetraspanin CD151 is required for both a3 and 

a6 integrin function. S. Zevian, N. Winterwood, M. Meland 

and C. Stipp. Univ. of Iowa. 

896. Plant Biochemistry 

Poster 



B293 896.1 Biodegradation of cellulosic wastes using 

Aspergillus niger: prospect for poultry feed formulation. M.O. 

Babalola, I.V. Okochi and U.A. Okafor. Univ. of Lagos, 

Nigeria. 

B294 896.2 Investigation of mutations of sunflower 

cotyledon acetoacetyl CoA thiolase. M. Cadet, I. Gomez, A.C. 

Schiedel, S. Oeljeklaus and J.H. Dyer. Montclair State Univ., 

NJ, PharmaCtr. Bonn and Ruhr Univ. Bochum, Germany. 

B295 896.3 Identifying the functional orthologs of lipid 

transfer proteins for developmental regulation in flowering 

plants. S.L. Caonguyen, S.J. Patel and R.L. Vellanoweth. 

California State Univ., Los Angeles. 


B296 896.4 Expression and purification of sunflower 

cotyledon acetoacetyl CoA thiolase mutants. I. Gomez, M. 

Cadet, S. Oeljeklaus, A.C. Schiedel and J.H. Dyer. Montclair 

State Univ., Ruhr Univ. Bochum and PharmaCtr. Bonn. 

B297 896.5 Expression of single chain antibody variable 

regions against botulinum neurotoxin-A in the unicellular green 

alga Chlamydomonas reinhardtii. S. Jeong, A. Vo and A. 

Cohen. California State Univ., Fullerton. 

B297A 896.6 Anatomical deviations caused by a monopartite 

geminivirus infection in tissues of tomato plants. M.S. 

Montasser. Univ. of Kuwait. 

897. Integration of Carbon and Nitrogen 

Metabolism 

Poster 



B298 897.1 Enzyme involved in degradation of isonitrile 

with a nitrogen-carbon triple bond. M. Kobayashi, H. Sato and 

Y. Hashimoto. Univ. of Tsukuba, Japan. 

898. Regulation of Plant Metabolism 

Poster 



B299 898.1 Divergent biochemical roles for cytosolic and 

chloroplastic pyruvate phosphate dikinase regulatory protein. 

C.J. Failing and C.J. Chastain. Minnesota State Univ. 

Moorhead. 

B300 898.2 Regulatory dephosphorylation of catalytic 

His-P of inactive PPDK in maize. L. Manandhar and C.J. 

Chastain. Minnesota State Univ. Moorhead. 

899. Computational Approaches in Systems 

Biology 

Poster 



B301 899.1 Comparative analysis of genome-scale 

metabolic models for Mycoplasma genitalium, Ureaplasma 

parvum, and Mycoplasma hominis reveals novel routes through 

the pentose phosphate pathway. M. DeJongh, N.B. Poel, A.A. 

Best and C.S. Henry. Hope Col., MI and Argonne Natl. Lab., 

IL. 

900. Electrophoresis 

Poster 



B302 900.1 Characterization of charge-variant 

bioconjugates derived from chemical labeling of proteins. G. 

Burgos, T. Rae, R. Bonn, J. Fishpaugh, J. Munoz, M. Pope 

and B. Bax. Abbott. 

270

tuesday 

B303 900.2 Evaluation of rapid western blot incubation 

system. E.Z. Lang, K.R. Rupprecht, T.D. Rae and J.R. 

Fishpaugh. Abbott Diagnostics Division. 

901. Experimental and Computational 

Approaches to Systems Biology 

Poster 



B304 901.1 Systems biology approaches to characterize 

exposures to infectious agents. R. Hammamieh and M. Jett. 

Walter Reed Army Inst. of Res. 

B305 901.2 Replacement of aromatic amino acids based on 

their consensus temporal order suggests that ancient proteins 

tend to be intrinsically disordered. J. Meng, D. Johnson, C. 

Oldfield, V. Uversky and A.K. Dunker. Indiana Univ. Purdue 

Univ. Indianapolis, Inst. for Biol. Instrument., Russian Acad. of 

Sci., Moscow. 

B306 901.3 Staphylococcus enterotoxin B-induced host 

response signatures in the presence and absence of battlefieldlike 

stress. S. Muhie, R. Hammamieh, D. Yang and M. Jett. 

Georgetown Univ. and Walter Reed Army Inst. of Res. 

902. New Frontiers in Genomics and 

Quantitative Proteomics 

Poster 



B307 902.1 Stoichiometric quantification of Akt 

phosphorylation using LC-MS/MS. A. Atrih, D. Turnock, G. 

Sellar, A. Thompson, M. Ferguson and J. Huang. Sch. of Life 

Sci., Univ. of Dundee and Pfizer Inc., U.K. 

B308 902.2 How to use the PSI Structural Genomics 

Knowledgebase to enable research. H.M. Berman, J. 

Westbrook, M. Gabanyi, Y-P. Tao, R. Shah, T. Schwede, K. 

Arnold, F. Kiefer, L. Bordoli, P. Adams, L. Carter, W. Minor 

and J. LaBaer. Rutgers Univ., Piscataway, Univ. at Basel, 

Lawrence Berkeley Natl. Lab., Univ. of Virginia and Arizone 

State Univ. 

B309 902.3 Biomarker discovery by stable isotope 

labeling and quantitative proteomics. M.D. Filiou, Y. Zhang, L. 

Teplytska, S. Reckow, E. Frank, M.S. Kessler, G. Maccarrone, 

B. Hambsch, R. Landgraf and C.W. Turck. Max Planck Inst. of 

Psychiatry, Munich. 

B310 902.4 Comparing nematode enhancers: conservation, 

divergence, and co-evolution. I. Ruvinsky. Univ. of Chicago. 

903. New Molecular and Cellular Imaging 

Agents 

Poster 



B311 903.1 Fluorescent peptide biosensors for imaging 

protein kinases involved in cell proliferation and cancer. 

M.C. Morris, L. Kurzawa and M. Pellerano. CRBM-CNRS, 

Montpellier. 

Biochemistry 

B312 903.2 IMAGEtag (intracellular multiaptamer genetic 

tag) for real-time imaging of gene promoter activity. I. Shin, 

M. Ilgu, H.E. Haarberg, V. Gupta, G.A. Kraus and M. Nilsen- 

Hamilton. Iowa State Univ. 

904. Posttranslational Modifications 

Poster 



B313 904.1 Defining the mechanisms by which 

palmitoylation regulates the localization and function of 

RGS4. K. Dissanayake, G. Bastin and S.P. Heximer. Univ. of 

Toronto. 

B314 904.2 Thioredoxin interacting protein is feedback 

regulator of S-nitrosylation. M.T. Forrester, D. Seth, A. 

Hausladen, C.E. Eyler, M.W. Foster, A. Matsumoto, M. 

Benhar, H.E. Marshall and J.S. Stamler. Duke Univ. Med. 

Ctr., Case Western Reserve Univ., Osaka Univ. and Technion - 

Israel Inst. of Technol. 

B315 904.3 Investigating the catalytic mechanism of the 

yeast palmitoyltransferase Akr1p. X. Guan, A.F. Roth, N.G. 

Davis and C.A. Fierke. Univ. of Michigan and Wayne State 

Univ. Sch. of Med. 

B316 904.4 Molecular recognition of FTase and GGTase-I 

in vivo. C.L. Lamphear and C.A. Fierke. Univ. of Michigan. 

B317 904.5 Formation of w-NG–monomethylarginine as 

the sole product of human protein arginine methyltransferase 

7: a true type III methyltransferase C.I. Lopez, T. Sandberg 

and S.G. Clarke. UCLA. 

B318 904.6 Tropomyosin phosphorylation in healthy and 

diseased hearts. H.N. Sheikh and D.F. Wieczorek. Dubai Med. 

Col. and Univ. of Cincinnati Med. Ctr. 

B319 904.7 Generation of O-GlcNAc specific monoclonal 

antibodies using a novel synthetic immunogen. C-F. Teo, S. 

Ingale, M.A. Wolfert, G.A. Elsayed, L.G. Not, J.C. Chatham, L. 

Wells and G-J. Boons. Univ. of Georgia and Univ. of Alabama 

at Birmingham. 

905. Quantitative Analysis of 

Posttranslational Modifications 

Poster 



B320 905.1 Quantitative proteomics for analyzing the 

histone code. B.A. Garcia. Princeton Univ. 

B321 905.2 Quantitative phosphoproteomics of 

depolarization-dependent protein phosphorylation in nerve 

terminals. M.R. Larsen, G. Palmisano, K. Engholm-Keller, 

K. Kulej, J. Xue, M. Graham and P.J. Robinson. Univ. of 

Southern Denmark and kChildren’s Med. Res. Inst., Sydney. 

B322 905.3 Quantitative chemical proteomics of dynamic 

palmitoylation. B. Martin and B. Cravatt. The Scripps Res. 

Inst. 

B323 905.4 Identifying protease cleavage sites by labelfree 

mass spectrometry. Q. Sun, N. Gupta, P. Cieplak, W. Zhu, 

B. Ratnikov, P.A. Pevzner and J.W. Smith. Burnham Inst. for 

Med. Res., La Jolla and UCSD. 

271 

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iochemistry 

B324 905.5 Simultaneous quantification of histone 

acetylation, methylation and ubiquitination at multiple sites 

by LC/MS/MS-MRM. K. Zhang, M. Schrag, A. Darmanto, A. 

Semotiuk, G. Xu and W. Kirsch. Loma Linda Univ. and Inst. of 

Biochem. and Cell Biol., Shanghai. 

906. Recombinant DNA Technology 

Poster 



B325 906.1 Lentiviral vector expressing Nef as a tool to 

study HIV neuropathology. E.A. Cruz and R.J. Noel. Ponce 

Sch. of Med., PR. 

B326 906.2 Characterization of bovine 20a-HSD gene 

promoter. K-S. Min, N. Purevjargal and M-H. Kang. Hankyong 

Natl. Univ. and Hoseo Univ., Republic of Korea. 

B327 906.3 Construction of the broad range cloning vector 

pHC60mCherry: plant-microbe interaction applications. G.A. 

Ramirez, N. Vozza, A. Zorreguieta and M. Tolmasky. California 

State Polytech Univ., Pomona, Inst. Fndn. Leloir, Buenos Aires 

and California State Univ., Fullerton. 

907. Chemical Biology and Drug Discovery 

Poster 



B328 907.1 Fluorescent intercalator displacement as a tool 

for RNA-ligand discovery. P.N. Asare-Okai and C.S. Chow. 

Wayne State Univ. 

B329 907.2 Chemical protein modification: tools for 

synthetic biology. G. Bernardes. Max Planck Inst., Berlin. 

B330 907.3 Structure based design and structure activity 

relationship of new reversible peptides inhibitors of thrombin 

derived from D-Phe-Pro-Arg substrate peptide. C.C. Clement 

and M. Philipp. Albert Einstein Col. of Med. and Lehman Col., 

CUNY. 

B331 907.4 Thermal stability assay for glaucoma-causing 

myocilin mutants using maltose binding fusion protein. J.L. 

Harris, R. Lieberman, J.N. Burns and S. Orwig. Capital Univ. 

OH and Georgia Tech. 

B332 907.5 Shape-shifting proteins with a potential link to 

drug side effects. S.H. Lawrence, T. Selwood, U.D. Ramirez, 

L. Stith and E.K. Jaffe. Fox Chase Cancer Ctr. 

B333 907.6 A screening assay for Z a1-antitrypsin 

aggregation. M.J. LeMieux, E. Rowe and V. Berthelier. Univ. 

of Tennessee Grad. Sch. of Med. 

B334 907.7 Imaging the distribution of carbon-11 labeled 

rifampicin, isoniazid and pyrazinamide in baboons using PET. 

L. Liu, J.M. Hooker, J.S. Fowler and P.J. Tonge. Stony Brook 

Univ. and Brookhaven Natl. Lab. 

B335 907.8 Development of a peptide nucleic acid-based 

siRNA delivery system. T.U. Naik and M.O. Sullivan. Univ. of 

Delaware. 

B336 907.9 Screen for chemical modulators of the laminininduced 

clustering of dystroglycan reveals novel inhibitors of 

aquaporin-4 polarized distribution in astrocytes. G.P. Noel, S. 

Stevenson and H. Moukhles. Univ. of British Columbia. 

B337 907.10 Hyperactive mice show elevated D2High 

receptors, a model for schizophrenia: calcium/calmodulindependent 

kinase II alpha knockouts. G. Novak and P. Seeman. 

Univ. of Toronto. 

B338 907.11 SAR studies of diphenyl ethers, potential antituberculosis 

drugs as InhA inhibitors. P. Pan, N. Liu, R.A. 

Slayden and P. Tonge. Stony Brook Univ. and Colorado State 

Univ. 

B339 907.12 Binary selectivity for HCV NS3/4A protease 

versus host proteases via irreversible inactivation at a noncatalytic 

cysteine. R.C. Petter, M. Hagel, D. Niu, T. St. Martin, 

M.P. Sheets, L. Qiao, H. Bernhard, R. Karp, Z. Zhu, M.T. 

Labenski, P. Chaturvedi, M. Nacht, W. Westlin and J. Singh. 

Avila Therapeut., Waltham, MA. 

B340 907.13 Allosteric modulators of a protein kinase via 

disulfide-trapping. J.D. Sadowsky and J. Wells. UCSF. 

B341 907.14 Selection of aptamers against live E. coli cells 

using cell SELEX. S.L. Shipley, E. White and S-K. Kim. Baylor 

Univ. 

B342 907.15 Using a combination of chemical and systems 

biological approaches for defining a mechanism by which a 

novel anti-aging compound greatly extends yeast longevity. V. 

Titorenko, A. Goldberg, S. Bourque, A. Beach, M. Burstein, 

V. Richard, P. Kyryakov, C. Gregg, T. Boukh-Viner, M. Juneau 

and A. Glebova. Concordia Univ., Canada. 

908. Chemical Biology: Evolution, 

Engineering and Design 

Poster 



B343 908.1 Physical models of enzymes engineered for 

biofuel cells: 2010 Pingry School SMART team project. T.S. 

Hata, S. Banta, E. Campbell, T. Herman, C. Ha, E. Kong, F. Ma, 

D. Ober, M-L. Picard, D. Sukhin, D. Sun, R. Vollbrechthausen, 

C. Wang, E. Xiao and D. O’Mara. Pingry Sch., Martinsville, NJ, 

Columbia Univ. and Milwaukee Sch. of Engin. 

B344 908.2 Combinatorial design of a four-helix bundle 

protein using high-throughput thermal scanning. T.J. Magliery, 

J.J. Lavinder, S.B. Hari, C. Nguyen and S. Sen. Ohio State 

Univ. 

B345 908.3 Novel transformations in the biosynthesis of 

the marine-derived antibiotic marinopyrrole. K.S. Ryan, T.A.M. 

Gulder and B.S. Moore. UCSD. 

909. Drug Resistance 

Poster 




B346 909.1 Investigation of class I integron presence and 

subsequent variable region characterization of 15 clinical 

isolates from Buenos Aires, Argentina. J. Kim, J. Mercado, D. 

Centron and M. Tolmasky. California State Univ., Fullerton 

and Univ. of Buenos Aires. 

B347 909.2 Biophysical basis for TetX mediated antibiotic 

resistance. K. Walkiewicz, K. Lau and Y. Shamoo. Rice Univ. 


tuesday 

910. Fragment-Based Drug Discovery: Size 

Matters 

Poster 



B348 910.1 Informatics-driven, fragment-based drug 

discovery and refinement engine coupled with integrative 

pharmacology screens effectively prioritizes novel CNS 

experimental therapeutic selection. L.K. Chico and D.M. 

Watterson. Northwestern Univ., Chicago. 

911. Modulation of Enzyme Activation 

Poster 



B349 911.1 Activation of mice skeletal muscle 

6-phosphofructo-1 kinase by serotonin is mediated by PLC-b 

PKC dependent pathway. W.S. Coelho and M. Sola-Penna. 

UFRJ, Rio de Janeiro. 

B350 911.2 Oxidative inhibition of MAPKAP kinase 

2 is predominately mediated through the activation loop 

cysteine. B.J. Forsberg, R. Patel, C. Schumacher and C.A. 

Chrestensen. Kennesaw State Univ. 

912. Protein-Small Molecule Interactions 

Poster 



B351 912.1 Role of heme in the regulation of signaling 

kinases. P. Balamurugan, A. Arvey, X. Yao, D. Huyn, C. 

Leslie and L. Zhang. Univ. of Texas at Dallas and Mem. Sloan- 

Kettering Cancer Ctr. 

B352 912.2 Neurosteroid binding domains of the NMDA 

receptor NR2B and NR2D subunits. K. Cameron, B. Borkowski, 

J. Kim, S. Rhoads, G. Cassada, M. Rocha and L. Gentile. 

Univ. of Richmond. 

B353 912.3 Spectroscopic and functional characterization 

of the nitric oxide adducts of the Fe(III) and Fe(II) states of the 

CO-sensing transcription factor, CooA, from Carboxydothermus 

hydrogenoformans. R.W. Clark, E. Jani, A.R. Francis, E. 

LaRoche and I. Malone. Valparaiso Univ. and Hope Col. 

B354 912.4 Mammalian sperm are dependent on JAM-A for 

normal motility: progressing from mice to humans. J. Huynh, R. 

Aravindan and P.A. Martin-DeLeon. Univ. of Delaware. 

B355 912.5 Impact of nitric oxide treatment on the 

spectroscopic properties and DNA binding activity of the 

carbon monoxide-sensing heme transcription factor, CooA. E. 

Jani and R.W. Clark. Valparaiso Univ. 

B356 912.6 Urate responsive MarR homolog from 

Agrobacterium tumefaciens. I.C. Perera and A. Grove. LSU. 

B357 912.7 Bioorthogonal ligation using site-specific 

tetrazine-alkene coupling on proteins. C.A. Refakis, M.L. 

Blackman, J.M. Fox and R.A. Mehl. Franklin & Marshall Col. 

and Univ. of Delaware. 

B358 912.8 Characterization of bivalent peptides that bind 

to X-linked inhibitor of apoptosis protein. K. Speer and K. 

Splan. Macalester Col. 

B359 912.9 Impact of heme reconstitution on the 

spectroscopic properties and DNA binding activity of the H82A 

variant of the carbon monoxide-sensing heme transcription 

factor, CooA. R.E. Troester and R.W. Clark. Valparaiso Univ. 

B360 912.10 Mutagenesis studies to investigate ligand 

binding to the carbon monoxide-sensing heme protein, CooA, 

from Carboxydothermus hydrogenoformans. L. Wagoner, J. 

Wagoner, T.E. Goyne and R.W. Clark. Valparaiso Univ. 

913. Small Molecule Modulation of Protein 

Folding and Assembly 

Poster 



B361 913.1 Protein quaternary structure focus for small 

molecule allosteric control. E.K. Jaffe, S.H. Lawrence and T. 

Selwood. Fox Chase Cancer Ctr. 

914. Small Molecule Tools for Biology 

Poster 



Biochemistry 

B362 914.1 Exploring hydra biology using chemical 

genetics. K.M. Glauber, C.E. Dana, S.S. Park, T. Li, A.R. 

Chamberlin and R.E. Steele. Univ. of California, Irvine and 

Anchen Pharmaceuts. Inc., Irvine. 

B363 914.2 Peroxisome proliferator-activated receptorg 

agonist rosiglitazone increases expression of lipin-1 in 

adipocytes. J. Kim, D.C. Han and B-M. Kwon. Korea Res. 

Inst. of Biosci. and Biotechnol., Daejeon and Univ. of Sci. and 

Technol. in Korea. 

B364 914.3 Bioluminescent amplification assay for 

microRNA detection. Y. Sun and V. Golovlev. Sci-Tec Inc., 

Knoxville. 

B365 914.4 Design of ultra-sensitive diagnosis for anthrax 

protective antigen base on polyvalent-directed peptide polymer 

using horizontally stacked hexagonal ZnO platelets. M.Y. Yoon. 

Hanyang Univ., Republic of Korea. 

B366 914.5 Small molecule activation of apoptotic 

caspases. J.A. Zorn, D.W. Wolan, D.C. Gray and J.A. Wells. 

UCSF. 

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nutritioN 


Nutrition 

915. One Carbon Metabolism Nutrients II 

Poster 


Presentation time: 12:45 p m-1:45 p m (I); 1:45 p m-2:45 p m (II) 

A1 I 915.1 Interconversions of plasma folate 

species in response to dosing with oral folic acid and 

5-methyltetrahydrofolate: an LC-MS/MS pilot study. Z. Fazili, 

S.W. Bailey, N. Paladugula, J.E. Ayling and C.M. Pfeiffer. 

Ctrs. for Dis. Control and Prevent. and Univ. of South Alabama. 

A2 II 915.2 Acculturation factors and the 

proportion of older Mexican Americans with inadequate folate 

intakes: National Health and Nutrition Examination Survey, 

2003–2006. H.C. Hamner, M.E. Cogswell and M.A. Johnson. 

Ctrs. for Dis. Control and Prevent. and Univ. of Georgia. 

A3 I 915.3 Acculturation factors and usual folate 

intakes among Mexican American women: National Health 

and Nutrition Examination Survey, 2003–2006. H.C. Hamner, 

M.E. Cogswell and M.A. Johnson. Ctrs. for Dis. Control and 

Prevent. and Univ. of Georgia. 

A4 II 915.4 Impact of vitamin B-6 availability 

on gluconeogenesis from amino acid precursors in human 

hepatoma (HepG2) cells. V.R. Da Silva, M. Ralat and J.F. 

Gregory III. Univ. of Florida. 

A5 I 915.5 Associations between folate, 

DNA methylation, methylenetetrahydrofolate reductase 

polymorphisms, and colorectal cancer risk: a review. S.G. 

Miszewski, A. Nazmi and D. Derelian. California Polytech 

State Univ., San Luis Obispo. 

A6 II 915.6 Phenotypes in utilization of formate 

for purine nucleotide biosynthesis de novo in adult humans. J.E. 

Baggott, G.S. Gorman and S.L. Morgan. Univ. of Alabama at 

Birmingham and Southern Res. Inst. 

A7 I 915.7 Paternal folate deficiency during 

reproduction influences folate concentrations in the brain of the 

offspring. H.W. Kim, Y.A. Lee, H-H. Kim, S. Lee and N. Chang. 

Ewha Womans Univ. and Col. of Med., CHA Univ., Republic of 

Korea. 

A8 II 915.8 BHMT deletion results in altered sulfurcontaining 

amino acids, disturbed one-carbon metabolism, 

elevated hepatic fat deposition, and diminished white adipose 

tissue mass. Y-W. Teng and S.H. Zeisel. Univ. of North Carolina 

at Chapel Hill. 

A9 I 915.9 Effect of nitrous oxide explosure 

during surgery on homocysteine concentrations of children. 

D. Pichardo, I. Luginbuehl, Y. Shakur and P. Wales. Univ. of 

Toronto and SickKids, Toronto. 

A10 II 915.10 Genistein mediates perturbations in 

one-carbon metabolism during diet-induced folate deficiency. 

E.B. Nonnecke and K.L. Schalinske. Iowa State Univ. 

A11 I 915.11 Characterization of methyl group 

metabolism in the non-obese diabetic mouse. J.C. Neuman, 

K.M. Nieman and K.L. Schalinske. Iowa State Univ. 

A12 II 915.12 In vivo enrichment of chicken eggs 

with 14C-B12 for determining vitamin B12 bioavailability 

in humans. M.G. Garrod , J.W. Miller, C.C. Calvert, B.A. 

Buchholz, R. Green, H.A. Johnson and L.H. Allen. USDA, 

Davis., Univ. of California Davis, Sacramento, Sch. of Vet. Med., 

Univ. of California, Davis and Lawrence Livermore Natl. Lab. 

916. Selenium 

Poster 



A13 I 916.1 Selenocysteine abundance was 

decreased in the hepatic GPX1 protein of SOD1-/- mice. S.K. 

Wang, S. Zhang and X.G. Lei. Cornell Univ. 

A14 II 916.2 Effects of dietary Se deficiency 

or excess on gene expression of 13 novel selenoproteins in 

growing pigs. H. Zhao, Q. Zhang, K. Li, J. Tang, X-J. Xia, K-N. 

Wang and X.G. Lei. Sichuan Agr. Univ., People’s Republic of 

China and Cornell Univ. 

A15 I 916.3 Gene expression profile of 

selenoproteins in an obese pig model induced by a high-fat 

diet. K. Li, H. Zhao, X. Xia and X.G. Lei. Sichuan Agr. Univ., 

People’s Republic of China and Cornell Univ. 

A16 II 916.4 Effects of selenium source on blood 

selenium content, blood cell counts and peripheral blood 

mononuclear cell mRNA profiles in maturing beef heifers. K.M. 

Brennan, W.R. Burris, J.A. Boling and J.C. Matthews. Alltech 

Inc., Nicholasville, KY and Univ. of Kentucky. 

A17 I 916.5 Methylselenol, a selenium metabolite, 

plays common and different roles in colonic cancer and 

nontumorigenic colonic cell growth. H. Zeng, M. Briske- 

Anderson and M.P. Moyer. USDA, Grand Forks and INCELL 

Corp., San Antonio. 

A18 II 916.6 Effect of physiological levels of sodium 

selenite on the expression and regulation of hypermethylated 

tumor supressor gene in human breast cancer cell line. Y-H. 

Chen, F.L. Yang, C-F. Kao and Y. Chen. Fu Jen Catholic Univ., 

Taiwan and Inst. of Cellular and Organismic Biol., Acad. Sinica, 

Taipei. 

A19 I 916.7 Selenoprotein P reduces lipid 

hydroperoxides in human embryonic kidney cells following 

exposure to 15-hydroperoxyeicosatetraenoic acid. C. Rock 

and P.J. Moos. Univ. of Utah. 

A20 II 916.8 The mismatch repair protein hMLH1 

regulates selenium-induced DNA damage response in 

colorectal cancer cells. Y. Qi, N.W. Schoene and W-H. Cheng. 

Univ. of Maryland College Park, Sch. of Life Sci., Lanzhou 

Univ., People’s Republic of China and USDA , Beltsville, MD. 

A21 I 916.9 ATM is upstream of DNA-PK cs 

in the 

activation of DNA damage response by sodium selenite. C. 

Rocourt and W-H. Cheng. Univ. of Maryland College Park. 

A22 II 916.10 Selenium supplementation for 6 

months increases plasma selenium levels in HIV + adults in 

Botswana. S. Sales, L. Tsalaile, P.J. Burns, A. Campa, J. 

Makhema, R. Marlink and M.K. Baum. R. Stempel Col. of 

Publ. Hlth. and Soc. Work, Florida Intl. Univ., Botswana Harvard 

Partnership, Gaborone and Harvard Sch. of Publ. Hlth. 

A23 I 916.11 Basal diet composition determines 

effects of supplemental selenium. T.E. Quiner, H.S. Lindsay, 

B.A. Mason, E.D. Lephart and M.J. Christensen. Brigham 

Young Univ. 

A24 II 916.12 Characterization of selenoprotein V. 

M.E-S. Moustafa and R. El-Srouji. Beirut Arab Univ. 

A25 I 916.13 tRNA (Ser)Sec coexpression affects 

SECp43 levels in HEK 293 cells. C.L. Gilman, L.A. Seale, A. 

Seyedali and M.J. Berry. Univ. of Hawaii at Manoa. 


tuesday 

A26 II 916.14 Selenocysteine lyase expression in 

selenoprotein P knockout mouse. L.A. Seale, C.L. Gilman, 

A.C. Hashimoto, A. Seyedali and M.J. Berry. Univ. of Hawaii 

at Manoa. 

A27 I 916.15 Analysis of selenium in meats and 

meat products using INAA-method. O. Lee, Y. Chung and 

J. Moon. Yongin Univ., Republic of Korea and Korea Atomic 

Energy Res. Inst., Daejeon. 

917. Calcium, Phosphorus, Magnesium, and 

Vitamin D 

Poster 



A28 I 917.1 Intestinal cell calcium uptake and 

the targeted knockout of the 1,25D 3 

-MARRS receptor/PDIA3/ 

ERp57. I. Nemere, N. Garbi and G. Hammerling. Utah State 

Univ. and German Cancer Res. Ctr., Heidelberg. 

A29 II 917.2 Weight loss is associated with 

increased serum 25(OH)vitamin D in overweight or obese 

women. C.L. Rock, D.D. Heath, S.W. Flatt, N. Karanja, B. 

Pakiz, N.E. Sherwood and C.A. Thomson. UCSD, Kaiser 

Permanente, Ctr. for Hlth. Res., Portland, OR, Univ. of 

Minnesota, Minneapolis and Univ. of Arizona. 

A30 I 917.3 Effect of magnesium on heart rate 

variability in healthy subjects. L. Brilla, L. Teichler, T. Hahn, J. 

Freeman and Y. Li. Western Washington Univ. 

A31 II 917.4 Vitamin D status in Saudi Arabian 

women: is there an association with breast cancer risk F.M. 

Yousef, C. Thomson, T. Kumosani and J. Yousef. Univ. of 

Arizona and King Abdulaziz Univ., Saudi Arabia. 

A32 I 917.5 Changes in vitamin D status of female 

soldiers during basic combat training. N.E. Andersen, J.P. Karl, 

J.E. Diaz, S.J. Cable, K.W. Williams, J.C. Rood, A.J. Young, 

H.R. Lieberman and J.P. McClung. U.S. Army Res. Inst. of 

Envrn. Med., Natick, MA, Directorate of Basic Combat Trng., 

Fort Jackson, SC and Pennington Biomed. Res. Ctr., Baton 

Rouge. 

A33 II 917.6 Intakes and sources of vitamin D in 

the U.S. population. J.K.C. Ahuja, D. Rhodes, J.D. Goldman, 

G. Omolewa-Tomobi, R. LaComb and A. Moshfegh. USDA, 

Beltsville, MD. 

A34 I 917.7 Age related changes in CTX type 

bone biomarkers are differently affected by calcium status. 

M.E. Río, H.C. Dupraz, L.B. Zago, N. Piazza and S.N. Zeni. 

Univ. of Buenos Aires and CONICET, Buenos Aires. 

A35 II 917.8 Vitamin D status of elderly Mayan 

residents of the Western highlands of Guatemala. O.I. 

Bermudez, S. Sud, G. Montenegro-Bethancourt, R. Heaney, 

L. Armas and N.W. Solomons. Tufts Univ. Sch. of Med., 

CeSSIAM, Guatemala City and Creighton Univ. 

A36 I 917.9 Vitamin K content of Hispanic foods. 

D. Haytowitz, S.L. Booth, J. Peterson and S. Barakat. USDA 

at Tufts Univ. 

A37 II 917.10 Hockey stick relationship between 25 

OH vitamin D and BMI NHANES. L. Arab, H. Kim and A. Ebel. 

David Geffen Sch. of Med. and Sch. of Publ. Hlth., UCLA and 

Humbolt Univ. Berlin. 

Nutrition 

A38 I 917.11 Markers of bone turnover, 

osteoprotegerin, and vitamin D across gestation in pregnant 

adolescents. B.V. Essley, T. McNanley, E. Cooper, A. McIntyre, 

T. Kent, M. Foehr, F. Witter, L. Harris and K.O. O’Brien. 

Cornell Univ., Univ. of Rochester Med. Ctr., Johns Hopkins Sch. 

of Med. and Vanderbilt Univ. Sch. of Med. 

A39 II 917.12 Effects of tomato and broccoli on 

the bone status of growing female rats with different levels of 

calcium intake. C. Wang, L. Huang and C. Butler. Kentucky 

State Univ. 

A40 I 917.13 Urine potassium is a valid biomarker 

for diet potassium and a surrogate measure of compliance to 

a high dairy intervention in teenage girls. K. Rafferty and J. 

Lappe. Creighton Univ. 

A41 II 917.14 Physical exercise practice influences 

serum concentrations of 25(OH)D and PTH in spinal cord 

injured men. A. Chain, J.C. Koury, F.A. Figueiredo, G.L.C. 

d’Oliveira and F.F. Bezerra. Fed. Univ. of Rio de Janeiro and 

Brazilian Inst. of Rights of People with Disabil., Rio de Janeiro. 

A42 I 917.15 Possible rise in Ca:Mg ratio from food 

intake in USA adults. A. Rosanoff. Ctr. for Magnesium Educ. & 

Res. LLC, Pahoa, HI. 

A43 II 917.16 Vitamin D/calcium-mediated apoptosis 

in cancer cells and adipocytes. I.N. Sergeev. South Dakota 

State Univ. 

A44 I 917.17 Low vitamin D status among 

overweight and obese Puerto Rican adults. K.E. Gil, C. 

Palacios, C.M. Perez and K. Joshipura. Univ. of Puerto Rico 

Med. Sci. Campus. 

A45 II 917.18 Megalin- and disabled-2-mediated 

uptake of vitamin D-binding protein is modulated by all-transretinoic 

acid in prostate and colon epithelial cells. S.B. Ternes 

and M.J. Rowling. Iowa State Univ. 

A46 I 917.19 Obesity prevalence according calcium 

status in adolescent women. M.E. Rio, A.L. Felipoff, L. Zago 

and N. Piazza. Univ. of Buenos Aires, CONICET, Ciudad 

Autonoma de Buenos Aires and Epidemiol., Vicente Lopez. 

A47 II 917.20 Effects of vitamin D supplementation 

during exercise training on strength and body composition. 

A.E. Carrillo, M.G. Flynn, C. Pinkston, M.M. Markofski, Y. 

Jiang, S.S. Donkin and D. Teegarden. Purdue Univ. and Col. 

of Charleston. 

A48 I 917.21 Magnesium supplementation attenuates 

aldosterone-induced hypertension, kidney damage and 

oxidative stress in genetically hypomagnesemic mice. A. Yogi, 

G.E. Callera, S.E. O’Connor, Y. He, R.C. Tostes, A. Mazur 

and R.M. Touyz. Univ. of Ottawa, Med. Sch. of Georgia and 

Natl. Inst. of Agron. Res., Saint-Genes-Champanelle, France. 

A49 II 917.22 Phosphate-dependent physiological 

changes during short-term dietary phosphorus deficiency with 

or without a dietary phosphorus binder. E.A. Bobeck and M.E. 

Cook. Univ. of Wisconsin-Madison. 

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nutritioN 

918. Dietary Bioactive Compounds IV: Anti- 

Obesity Medicinal Foods 

Poster 



A50 I 918.1 Sprasis crispa mushroom extract 

affects adipogenesis and lipolysis in 3T3-L1 cells. J-K. Park, 

M-A. Lee, Y-Y. Choi, H-R. Kim and Y.K. Park. Kyung Hee 

Univ., Republic of Korea. 

A51 II 918.2 Antiobesity effects of bioceramic 

stone water in C57BL/6 mice. S-S. Bak, J-Y. Kim, S-M. Lee, 

J-M. Byun and K-Y. Park. Pusan Natl. Univ., Republic of Korea, 

Sun Pi Korea, Busan. 

919. Dietary Bioactive Compounds IV: 

Antioxidant Medicinal Foods 

Poster 



A52 I 919.1 Coffee is the most important 

contributor to the total antioxidant capacity in Brazilians’ diet. T. 

Torres and A. Farah. Fed. Univ. of Rio de Janeiro. 

A53 II 919.2 Effect of peanut skin phenolics on 

pancreatic amylase activity and fructose-mediated albumin 

glycation. P.L. Garner, J.L. Hargrove, D.K. Hartle, R.B. Pegg 

and P. Greenspan. Univ. of Georgia. 

A54 I 919.3 Antioxidative effects of new herbal 

formula extracts. S.J. Park, N.Y. Kim, S.H. Park, W.B. Yoon 

and J.D. Kim. Hallym Col., Songho Col., Kunjang Col. and 

Kangwon Natl. Univ., Republic of Korea. 

920. Dietary Bioactive Compounds IV: Anti- 

Diabetic Medicinal Foods 

Poster 



A55 I 920.1 Combination of fenugreek and 

cayenne improves glucose handling of a type 2 diabetic mouse 

model. P. Hanlon, B. Eshelman, W. Harriman and D. Barnes. 

Standard Process Inc., Palmyra, WI and Univ. of Wisconsin 

-Whitewater. 

A56 II 920.2 Dietary cranberry, blueberry, and 

black raspberry affect the development of dyslipidemia and 

insulin insensitivity associated with metabolic syndrome in high 

fructose fed rats. R. Khanal, S. Wilkes, T. Rogers, L. Howard 

and R. Prior. Univ. of Arkansas and Arkansas Children’s Nutr. 

Ctr., USDA, Little Rock. 

A57 I 920.3 Effect on anti-diabetic effect of the 

mushrooms grown in germinated brown rice extracts in RIN 

and 3T3-L1 cells. Y-S. Cha, J-E. Park, H-J. Kang, J-R. Soh 

and S-H. Beak. Chonbuk Natl. Univ. and Haeddeulnal Co., 

Republic of Korea. 

A58 II 920.4 Development of medicinal food 

recipes including bitter gourd, fenugreek and guava for type 

II diabetes. K-l. Syu and C. Tam. California State Univ., Los 

Angeles, Pasadena and Monterey Park. 


A59 I 920.5 Morinda citrifolia (noni) inhibits hepatic 

gluconeogenesis via increased phosphorylation of forkhead 

transcription factor (FoxO1). P.V. Nerurkar, A. Nishioka, 

P.O. Eck, L.M. Johns, E. Volper and V.R. Nerurkar. Univ. of 

Hawaii. 

921. Dietary Bioactive Compounds III: 

Antioxidants and Free Radicals II 

Poster 



A60 I 921.1 Effects of regular black tea 

consumption on the antioxidant activity. M. Fisunoglu and H.T. 

Besler. Hacettepe Univ., Turkey. 

A61 II 921.2 Total antioxidant capacity of grape 

and pomegranate juices in vitro is dependent upon assay 

dilution factor. B.W. Bolling, J.B. Blumberg and C-Y.O. Chen. 

USDA at Tufts Univ. 

A62 I 921.3 Common plant foods consumed 

in Korea are rich source of phytochemicals. G-A. Yoon, Y-S. 

Cho, K-J. Yeum, C-Y.O. Chen, G. Tang, J.B. Blumberg, R.M. 

Russell, S. Yoon and Y.C. Lee-Kim. USDA at Tufts Univ., Dong- 

Ewi Univ., Republic of Korea, Florida Coastal Sch. of Law, OD, 

NIH and Yonsei Univ., Republic of Korea. 

A63 II 921.4 Composition and stability of 

phytochemicals in five varieties of black soybeans (Glycine 

max). C.R. Correa, L. Li, G. Aldini, M. Carini, C-Y.O. Chen, 

H-K. Chun, S-M. Cho, K-M. Park, R. Russell, J.B. Blumberg 

and K-J. Yeum. USDA at Tufts Univ., Univ. degli studi of Milan, 

Natl. Acad. of Agr. Sci. and Sungkunkwan Univ., Republic of 

Korea. 

A64 I 921.5 Effects of Ecklonia cava on plasma 

and liver lipids, platelet aggregation and RBC membrane 

stability in rats fed cholesterol diets. W.T. Yeh, Y-J. Jeon, 

Y-H. Kang and J.S. Kang. Jeju Natl. Univ. and Hallym Univ., 


A65 II 921.6 An integrated high resolution mass 

spectrometric and bioinformatic approach for the rapid 

identification of flavonoids in plant extract. G. Aldini, L. 

Regazzoni, M. Scevaroli, M. Carini, H-K. Chun, S.M. Cho, 

K.M. Park and K-J. Yeum. Univ. of Milan, Natl.Acad. of Agr. 

Sci., Suwon and Sungkyunkwan Univ., Republic of Korea and 


A66 I 921.7 Effect of manganese exposure and 

antioxidant therapy on oxidative stress in the rat brain. S. 

Fordahl, P. Cooney, D. Milatovic, M. Aschner and K. Erikson. 

Univ. of North Carolina at Greensboro and Vanderbilt Univ. 

A67 II 921.8 Antioxidant capacities of seven 

flavonoid compounds isolated from pulp of acai fruit (Euterpe 

oleracea). J. Kang, T. Wu, Z. Li, G.S. Jensen, A.G. Schauss 

and X. Wu. Univ. of Arkansas for Med. Sci., Shanghai Inst. 

of Pharmaceut. Industry, NIS Labs., Klamath Falls, OR and 

AIBMR Life Sci. Inc., Puyallup, WA. 

A68 I 921.9 Delphinidin alters hydrogen peroxideinduced 

cytotoxicity and apoptosis in human colon 

adenocarcinoma cells. Y. Tokarev and J.G. Fischer. Univ. of 

Georgia. 

A69 II 921.10 Antidiabetic effect of color potatoes in 

streptozocin-induced diabetic rats. M-H. Kang, M-K. Choi and 

Y-S. Jeon. Hoseo Univ., Kongju Natl. Univ. and Chungwoon 



tuesday 

A70 I 921.11 Anti-oxidative effects of fermented 

rice bran extract on H 2 

O 2 

-induced oxidative stress in 3T3-L1 

adipocytes. D. Kim, B. Jeong, J.P. Fan, H.C. Chung, H.S. Kim, 

Y.H. Ko and G.W. Kim. Col. of Natural Resources, Yeungnam 


A71 II 921.12 Cytoprotective activity of leaf crude 

extract of Eugenia uniflora L. and quercetin in insulin-producing 

cells. H.R. Emilio, S.M. Braatz, E.T. Felipe, M.R.P. Oliveira, 

C.C. Kanunfre, A.R. Carpinelli and R. Curi. State Univ. of 

Ponta Grossa, Brazil and Univ. of São Paulo. 

A72 I 921.13 Differential antioxidant and antiinflammatory 

activities of dietary polyphenols and vitamins. C. 

Hapner, S. Page, P. Deuster and Y. Chen. Uniformed Svcs. 

Univ. of Hlth. Sci. 

A73 II 921.14 Effects of decaffeination process 

on the phenolic content and antioxidant capacity of brewed 

coffees. M.R. Freeman, S.E. Landin and T. Wilson. Winona 

State Univ. 

A74 I 921.15 Polyphenolic content and antioxidant 

capacity of cranberry stem and leaf extracts. S.E. Landin, M.R. 

Freeman, N.L. Hoeft, C.J. Malone, A.P. Singh, N. Vorsa and T. 

Wilson. Winona State Univ. and Rutgers Univ., New Brunswick 

and Chatsworth. 

A75 II 921.16 Antioxidative properties of dark 

chocolate and bloomed dark chocolate. M.Y. Hong and T. 

Nemoseck. San Diego State Univ. 

A76 I 921.17 Camel’s milk alleviates oxidative 

stress and lipid peroxidation induced by chronic aluminum 

chloride exposure in rat’s testes. F.H. AL-Hashem. King Khalid 

Univ., Saudi Arabia. 

922. Dietary Bioactive Compounds IV: 

Medicinal Foods II 

Poster 



A77 I 922.1 Urinary excretion of chlorogenic acids 

and metabolites in humans after green mate (I. paraguariensis) 

consumption. V.X. Marques and A. Farah. Fed. Univ. of Rio de 

Janeiro. 

A78 II 922.2 Chlorogenic acids from green and 

roasted coffees are equally absorbed and metabolized by 

humans. M.C. Monteiro, V.X. Marques and A. Farah. Fed. 

Univ of Rio de Janeiro. 

A79 I 922.3 The addition of milk to coffee 

decreases the urinary excretion of chlorogenic acids and 

metabolites in humans when compared to plain coffee. G.S. 

Duarte and A. Farah. Fed. Univ. of Rio de Janeiro. 

A80 II 922.4 Effects of fermented soy food 

containing natural S-equol on tail skin temperature in 

ovariectomized rat. T. Yoneda, T. Ueno, S. Iwashita and S. 

Uchiyama. Otsuka Pharmaceut. Co. Ltd., Saga, Japan. 

A81 I 922.5 Quantitative analysis of ginsenoside 

composition in flower buds of Korean (Panax ginseng) and 

Chinese (Panax notoginseng) ginseng. S.K. Ko, O.S. Cho, 

H.M. Bae, B.O. Im, O-H. Lee and B-Y. Lee. Semyung Univ. 

and CHA Univ., Republic of Korea. 

Nutrition 

A82 II 922.6 Royal jelly enhances migration of 

human dermal fibroblasts with decreased levels of triglycerides 

and cholesterol in in vitro wound healing model. Y. Kim, H.J. 

Yun, J.A. Lee, H.M. Park, S.Y. Kim and Y. Cho. Grad. Sch. of 

East-West Med. Sci., Kyung Hee Univ., Republic of Korea. 

A83 I 922.7 Effect of dietary supplementation with 

Laminaria japonica and Laminaria saccharina on loperamideinduced 

constipation in rats fed high fat diet. K.J. Chang, Z. Xu, 

J. You, D. Huan and C.M. Lee. Inha Univ., Republic of Korea 

and Univ. of Rhode Island. 

A84 II 922.8 Antimicrobial and genotoxicity 

activities of medicinal plant extracts in vitro. S.J. Park, X. He 

and J. Ahn. Hallym Col. and Kangwon Natl. Univ., Republic of 

Korea. 

A85 I 922.9 Resistant starch content of rice varies 

with rice variety but not cooking method. M.L. Stewart and L. 

Manglicmot. Univ. of Hawaii at Manoa. 

A86 II 922.10 Quercetin supplementation and upper 

respiratory tract infection: a randomized community clinical trial. 

D.C. Nieman, S.A. Heinz, D.A. Henson, M. Austin and F. Jin. 

Appalachian State Univ. 

A87 I 922.11 Beta-glucan supplement reduces 

upper respiratory tract infections and improves mood state in 

healthy stressed subjects. S. Talbott, J. Talbott and D. Cox. 

SupplementWatch, Draper, UT and Biothera, Eagan, MN. 

A88 II 922.12 A simple and rapid method for 

induction of experimental allergy in mice. L. Christopher and 

S. Kuvibidila. Oklahoma State Univ. 

A89 I 922.13 Inhibitory effects of Rhaponticum 

uniflorum extract fractions on the biosynthesis of inflammatory 

mediators. G.H. Kim, K.H. Hwang and J-H. Lee. Duksung 

Women’s Univ., Republic of Korea. 

A90 II 922.14 Walnut type affects the response 

to occlusion-induced vasodilation following a high fat meal in 

dyslipidemic humans. P.J. Fitschen, B.K. Allen, M.A. Manzy 

and M.A. Maher. Univ. of Wisconsin-La Crosse. 

923. Fermented Foods and Probiotics II 

Poster 



A91 I 923.1 Lactobacillus bacteria strain Weissella 

koreensis OK1-6 mediated inhibition of intracellular lipid 

accumulation in 3T3-L1 cells: a plausible approach to obesity 

management. Y-S. Cha, P.B.T. Pichiah, Y-J. Moon and S-H. 

Oh. Chonbuk Natl. Univ. and Woosuk Univ., Republic of Korea. 

A92 II 923.2 Antiobesity effects of doenjang 

prepared with bioceramic stone water in 3T3-L1 adipocyte. S-S. 

Bak, J-K. Jeong, Z. Xin, E-J. Jeong and K-Y. Park. Pusan 

Natl. Univ., Republic of Korea. 

A93 I 923.3 Anti-inflammatory effects of 

docosahexaenoyl lysophosphatidylcholine in RAW 264.7 cells 

and in mice models. M. Kim, M. Sohn, D-E. Sok and M.R. Kim. 

Chungnam Natl. Univ., Republic of Korea. 

A94 II 923.4 Fish egg extract inhibits 

lysophospholipase D activity. M.R. Son, H.S. Yook and M.R. 

Kim. Chungnam Natl. Univ., Republic of Korea. 

A95 I 923.5 Antiobesity and inflammatory 

cytokines effect of Lactobacillus sps OPK-3 isolated from 

kimchi on 3T3-L1 preadipocytes. Y-S. Cha, J-E. Park and S-H. 

Oh. Chonbuk Natl. Univ. and Woosuk Univ., Republic of Korea. 

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nutritioN 

A96 II 923.6 High temperature and high pressure 

processed garlic improves lipid profiles in rat fed high cholesterol 

diet. B. You, C.W. Sohn, M.Y. Kim and M. Kim. Chungnam 


A97 I 923.7 Supplementation of high temperature 

and high pressure processed garlic reduces lymphocytes DNA 

damage and oxidative stress in rat fed high cholesterol diet. 

H.R. Kim, C.W. Sohn, M.H. Kim and M.R. Kim. Chungnam 


A98 II 923.8 Menu planning and recipe 

development using red yeast (Monascus purpureus) fermented 

rice and its products. O.S. Tzou, C.F. Tam, W-J. Lin and H-I. 

Chen. Sch. of Kinesiol. and Nutr. Sci., California State Univ., 

Los Angeles. 

A99 I 923.9 Effect of probiotics on dietary energyharvest 

by modulation of intestinal carbohydrate- and lipiddigesting 

enzymes. R. Cotten, D. Vattem, B.J. Friedman and 

V. Maitin. Texas State Univ. 

A100 II 923.10 Hypolipidemic effect of Lactobacillus 

acidophilus in Wistar strain albino rats fed with high fat diet. O.O. 

Adebawo, I.O. Banjoko, M.M. Adeyanju and O. Ademuyiwa. 

Olabisi Onabanjo Univ., Nigeria, Olabisi Onabanjo Univ. B, 

Saint Lucia and Univ. of Agr., Nigeria. 

924. Dietary Bioactives and Gene Expression 

Poster 



A101 I 924.1 Alcohol consumption and Western 

style diet alter colonic Sirt1 gene expression during aging. L.K. 

Park, J. Sauer, H. Jang, E.M. Zimmerly, S. Ledbetter and 

S-W. Choi. USDA at Tufts Univ. 

A102 II 924.2 Microarray analysis reveals effects on 

important biological pathways in the liver of mice fed a dietary 

soy isoflavone concentrate. N.F. Shay, M-L. Ricketts, T.I. 

Medrano and K.T. Shiverick. Univ. of Florida. 

A103 I 924.3 Regulation of ATP binding cassette 

transporter A1 (ABCA1) and ABCG1 by fatty acids in RAW 

264.7 macrophages. C.S. Ku, Y-K. Park, S.L. Coleman, J.M. 

Seo and J-Y. Lee. Univ. or Nebraska-Lincoln. 

A104 II 924.4 Abrogation of TCDD induced 

epigenetic silencing of BRCA-1 by resveratrol. A. Papoutsis, 

D. Romagnolo and O. Selmin. Univ. of Arizona. 

A105 I 924.5 Turmeric curcuminoids (Curcuma 

longa L.) interacts with microRNAs in the regulation of 

inflammation on human umbilical vein endothelial cells. G. 

Angel-Morales, G. Noratto and S. Mertens-Talcott. Texas 

A&M Univ. 

A106 II 924.6 Unsaturated fatty acids repress the 

expression of adipose fatty acid binding protein (aP2) in RAW 

264.7 macrophages. S.L. Coleman, Y-K. Park, C.S. Ku and 

J-Y. Lee. Univ. of Nebraska-Lincoln. 

A107 I 924.7 Selective effect of dyslipidemic 

human sera on in vitro gene expression. H. Zirpoli, M. Caputo, 

A. Carraturo, G. Torino, A. Fazio, M. Attya, L. Rastrelli and 

M.F. Tecce. Univ. of Salerno, Santa Maria Goretti Hosp., Latina 

and Univ. of Calabria, Italy. 


925. Immune Modulating Nutraceuticals and 

Functional Foods II 

Poster 



A108 I 925.1 Dietary supplementation with green 

tea EGCG at high dose promotes inflammatory response. M. 

Pae, Z. Ren, M. Meydani, F. Shang, S.N. Meydani and D. Wu. 


A109 II 925.2 Inhibitory effect of a Mori Cortex water 

extract on Th2 cytokine expression and b-hexosaminidase 

release by IgE antigen complex-stimulated RBL2H3 cells. J.M. 

Kim, M.J. Chung, D.J. Kim, T.H. Kim, J.M. Baek, S.C. Lee, 

C.A. Kim and M. Choe. Bori Nara and Nutraceut. Bio Brain 

Korea 21 Project Gp., Chunchon and Kangwon Univ., Republic 

of Korea. 

A110 I 925.3 Anti-asthma effects of water extract 

from Perillae semen on DNP IgE plus antigen-stimulated RBL- 

2H3 cells. J.M. Kim, M.J. Chung, D.J. Kim, T.H. Kim, J.M. Baek, 

S.C. Lee, C.A. Kim and M. Choe. Bori Nara and Nutraceut. 

Bio Brain Korea 21 Project Gp., Chunchon and Kangwon Univ., 


A111 II 925.4 Effects of Gelidium amansii gel 

extracts on immune responses in RAW 264.7 macrophages. 

M-L. Wang and Y-H. Chen. Taipei Med. Univ. 

A112 I 925.5 Effect of dietary yeast b-glucan on 

immune development in neonatal piglets. S.N. Hester, S.C. 

Cope, S.S. Comstock, M.H. Monaco and S.M. Donovan. 

Univ. of Illinois, Urbana. 

A113 II 925.6 Water soluble extracts from multiple 

mushroom varieties inhibit activation of Jurkat cells. B. Metzger, 

M.G. Williams, D. Barnes and P. Hanlon. Standard Process, 

Palmyra, WI. 

926. Animal Models of Gastrointestinal 

Health and Disease II 

Poster 



A114 I 926.1 Phylogenetic and gene-centric 

metagenomics of the canine gastrointestinal microbiome 

reveals similarities with human and mouse gut metagenomes. 

K.S. Swanson, S.E. Dowd, J.S. Suchodolski, I.S. Middelbos, 

B.M. Vester, K.A. Barry, K.E. Nelson, I.K.O. Cann, B.A. White 

and G.C. Fahey, Jr. Univ. of Illinois, Urbana, Res. and Testing 

Lab., Lubbock, Texas A&M Univ. and J. Craig Venter Inst., 

Rockville, MD. 

A115 II 926.2 Effects of dietary fat on resistant 

starch fermentation in mice. D. Badkoobeh, R.T. Tulley, R.J. 

Martin, A.M. Raggio, K.L. McCutcheon, F. Goldsmith, J. 

Zhou and M.J. Keenan. LSU AgCtr., Pennington Biomed. Res. 

Ctr. and VA Med. Ctr., Washington, DC. 

A116 I 926.3 Soluble fibers and resistant starch 

ameliorate disease activity in an experimental model of 

inflammatory bowel disease. J. Bassaganya-Riera, M. 

Diguardo, A. de Horna, S. Sanchez, A.W.C. Einerhand, L. 

Sanders and R. Hontecillas. Virginia Tech, Nutr. Therapeut. 

Inc., Blacksburg and Tate & Lyle Hlth. and Nutr. Sci., Decatur, 

IL. 


tuesday 

A117 II 926.4 Circadian regulator PER2 plays a 

critical role in regulating fat metabolism and the development 

of fatty liver disease. B.A. Pope, J. Menio, J. Deng and M.D. 

Wheeler. East Carolina Univ. 

A118 I 926.5 Poly (ADP-ribose) polimerase 

inhibition in experimental acute necrotizing pancreatitis. B. 

Uysal, M. Yasar, E. Oztas, S. Sadir, O. Coskun, T. Cayci, S. 

Oter, A. Guven and A. Korkmaz. Gulhane Military Med. Acad., 

Turkey. 

A119 II 926.6 Punicic acid modulates mucosal 

immune responses and prevents gut inflammation through 

PPAR g and D-dependent mechanisms. J. Bassaganya-Riera, 

M. Diguardo, M. Climent, C. Vives, A. de Horna, S. Sanchez, 

M. Orpi, E. Duran, A.W.C. Einerhand, M. O’Shea and R. 

Hontecillas. Virginia Tech, Nutr. Therapeut., Blacksburg and 

and Lipid Nutr. B.V., Channahon, IL. 

927. Animal Research Models in 

Macronutrient Metabolism II 

Poster 



A120 I 927.1 Dietary n-3 polyunsaturated fatty acids 

increased oxidative stress in rats with intracerebral hemorrhagic 

stroke. Y. Park. Hanyang Univ., Republic of Korea. 

A121 II 927.2 Nutritional support for piglets 

simulating nutrition support in the NICU. K. Smith and P.R. 

Borum. Univ. of Florida. 

A122 I 927.3 Identification of candidate genes 

responsible for the assembly of apolipoprotein-B containing 

lipoproteins in an avian system using estrogen induction. E.R. 

Trojacek, H. Zhou, X. Li, Y. Wang and R.L. Walzem. Texas 

A&M Univ. 

A123 II 927.4 A proposal to use golden-mantled 

ground squirrel (Spermaphilus lateralis) to study nonalcoholic 

fatty liver disease. M.L. Iao and C.F. Tam. California State 

Univ., Los Angeles. 

A124 I 927.5 Use of a mouse model for conjugated 

linoleic acid-induced changes in adipose depots. S.M. 

Ippagunta, K.M. Kanosky and K.M. Barnes. West Virginia 

Univ. 

A125 II 927.6 Role of mTOR/p70S6K in amino 

acid-induced cardiac protection. E. Katayama, R. Tsutsumi, Y. 

Nakaya, K. Hirose, K. Tanaka, S. Oshita and Y.M. Tsutsumi. 

Univ. of Tokushima, Japan. 

A126 I 927.7 The increase in Akt phosphorylation 

following feeding is independent of age in growing and mature 

thoroughbred mares. A.L. Wagner, J.C. Gould, R.B. Ennis 

and K.L. Urschel. Univ. of Kentucky. 

A127 II 927.8 High fat diet feeding impairs 

lactogenesis and butyrophilin expression in the mammary gland 

of mice. T.G. Anthony, J.K. Cundiff, K. Lohe, C. Parsons, I.H. 

Mather and R.M. Akers. Indiana Univ. Sch. of Med., Evansville, 

Virginia Tech and Univ. of Maryland College Park. 

A128 I 927.9 Using whole-body phenylalanine 

kinetics to measure the effects of amino acid supplementation 

in mature horses. K.L. Urschel, R.J. Geor, A.L. Wagner, L.M. 

Williamson, T.L. Smith, M.D. Hanigan and P.A. Harris. Univ. 

of Kentucky, Michigan State Univ., Virginia Tech and WALTHAM 

Ctr. for Pet Nutr., U.K. 

Nutrition 

A129 II 927.10 Ground squirrels as an animal 

research model for eating and metabolic disorders. M.A. 

Maher, B.M. Kohlnhofer, C. Abboud, W. Hill, J. Benrud and 

S.T. Cooper. Univ. of Wisconsin-La Crosse and Saint Louis 

Univ. 

A130 I 927.11 Pharmacological dose of alphatocopherol 

induces cardiotoxicity in Wistar rats determined by 

echocardiography and histology. A.L.A. Ferreira, M.C.M.O. 

Nascimento, B.B. Mastubara, L.S. Matsubara, C.R. Correa, 

E.J. Pereira, P.L. Moreira, F.A. Carvalho, C.H.P. Burini, C.R. 

Padovani and K-J. Yeum. Botucatu Med. Sch.-UNESP, Brazil 

and USDA at Tufts Univ. 

A131 II 927.12 Metabolic availability of threonine 

in common foodstuffs in pigs. C.L. Levesque, S. Moehn, P. 

Pencharz and R.O. Ball. Univ. of Alberta and Univ. of Toronto. 

A132 I 927.13 Cardiovascular and autonomic 

changes induced by 2 cardiovascular risk factors: salt and 

fructose. P. Fiorino, R. Yokota, C. Selles, R. Akemi, M. 

Fonteles and V. Farah. Mackenzie Univ., Brazil. 

A133 II 927.14 High fat diet primes the rat to glucose 

intolerance after low dose streptozotocin. V. Farah, H. Lopes, 

G. Dias, E. de Sousa, P. Fiorino and M. Fonteles. Mackenzie 

Univ., Brazil. 

928. Diet and Cancer, Micronutrients and 

Bioactive Molecules II 

Poster 



A134 I 928.1 A chemoenzymatic method to 

prepare gram-scale Allium organosulfur compounds and their 

presumptive metabolic products, and associated biological 

activities. G. Zhang and K.L. Parkin. Univ. of Wisconsin- 

Madison. 

A135 II 928.2 Justicidin A inhibits AKT/mTOR and 

activates type III PI3K/beclin 1 signaling pathways leading to 

autophagy of human colorectal cancer cells. C-L. Su, C-H. Yen, 

C-N. Lin and S-J. Won. Natl. Taiwan Normal Univ., Chang Jung 

Christian Univ., Sch. of Pharm., Kaohsiung Med. Univ. and Col. 

of Med., Natl. Cheng Kung Univ., Taiwan. 

A136 I 928.3 The polycyclic flavonoid, maackiain, 

arrests cell cycle progression in LNCaP and PC-3 human 

prostate cancer cells and repairs DNA damage in PC-3 and 

NHPrE cells. J.J. Zhang, N.W. Schoene, Y. Qi, A. Alshatwi, 

M. Alsaif and K.Y. Lei. Univ. of Maryland College Park, USDA, 

Beltsville, King Saud Univ., Saudi Arabia and Ctr. Excellence 

Biotech. Res., Riyadh. 

A137 II 928.4 Prolonged sulforaphane treatment 

activates extracellular-regulated kinase 1/2 signaling in 

nontumorigenic colon cells but not colon cancer cells. H. Zeng, 

O. Trujillo, M.P. Moyer and J.H. Botnen. USDA, Grand Forks, 

Univ. of Arizona and INCELL Corp., San Antonio. 

A138 I 928.5 The regulation of LIV-1 mRNA in 

MDA-MB-231 human breast cancer cells and its association 

with E-cadherin. L. Chong, K. Sankavaram and H.C. Freake. 

Univ. of Connecticut. 

A139 II 928.6 Intestinal tumors adapt to excess 

dietary iron by altering expression of a diverse set of 

oxidoreductases. J. Swain, C. Li and P. Leahy. Case Western 

Reserve Univ. 

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nutritioN 

A140 I 928.7 Hepatoprotective effects of 

equol through antioxidative and anti-apoptotic function in 

7,12-dimethylbenz[a]anthracene-induced oxidative stress 

of mice. G.H. Kim and E.J. Choi. Duksung Women’s Univ., 

Republic of Korea and Plant Resources Res. Inst., Seoul. 

A141 II 928.8 Zinc status and DNA damage in 

pediatric patients with acute lymphoblastic leukemia. P. 

Phoonlapdacha, S. Pakakasama, R.W. Kalpravidh, U. 

Suthutvoravut and N. Chongviriyaphan. Fac. of Med., 

Ramathibodi Hosp. and Siriraj Hosp., Mahidol Univ., Thailand. 

A142 I 928.9 In vitro screening of tumoricidal 

properties of international medicinal herbs. E.A. Mazzio, K. 

Park and K.F. Soliman. Col. of Pharm. and Pharmaceut. Sci., 

Florida A&M Univ. 

A143 II 928.10 Alpha-mangostin reduces HT-29 

colon cancer cell proliferation in vitro and inhibits transplantable 

tumorigenesis in vivo. C. Chitchumroonchokchai, S. 

Suksumrarn, J-G. Yu, S.K. Clinton and M.L. Failla. Ohio 

State Univ. and Srinakharinwirot Univ., Thailand. 

A144 I 928.11 NSAID-activated gene-1 as a 

molecular target for capsaicin-induced apoptosis through a 

novel molecular mechanism involving GSK3[beta], C/EBPb, 

and ATF3. S-H. Lee, C. Krisanapun and S.J. Baek. Univ. of 

Tennessee, Knoxville. 

A145 II 928.12 Disrupting vitamin D signaling 

increases androgen-dependent proliferation and reduces 

apoptosis in mouse prostate. J.C. Fleet, P. Kovalenko, Z. 

Zhang, J-G. Yu and S.K. Clinton. Purdue Univ. and Ohio State 

Univ. 

A146 I 928.13 Synergistic inhibition of colon cancer 

cell growth by 5-hydroxy nobiletin and atorvastatin. P. Qiu, 

P. Dong, R. Riddle and H. Xiao. Univ. of Massachusetts 

Amherst. 

A147 II 928.14 Inhibitory effects of resveratrol and 

pterostilbene on human colon cancer cells: a side-by-side 

comparison. W. Nutakul, H.S. Sober, P. Qiu, P. Dong and H. 

Xiao. Univ. of Massachusetts Amherst. 

A148 I 928.15 Broccoli inhibits colon inflammation 

and carcinogenesis in azoxymethane and dextran sulfate 

sodium-reated mice. S.M. Butler, C-W. Nho, C-H. Pan and 

E.H. Jeffery. Univ. of Illinois at Urbana-Champaign and KIST, 

Gangneung, Republic of Korea. 

A149 II 928.16 Phosphatidylinositol 3-kinase mediates 

the ability of retinol to inhibit colon cancer cell invasion in 

vitro. J.N. Griffin and M.A. Lane. Texas State Univ. 

A150 I 928.17 Prickly pear seed extracts with 

antioxidant and cancer-preventing capacity. D.R. Camarena- 

Ordonez, J. Gutierrez-Uribe, C. Hernandez-Brenes and S. 

Mertens-Talcott. Tecnol. of Monterrey, Mexico, Texas A&M 

Univ. 

A151 II 928.18 Impact of selenate treatment on 

broccoli glucosinolate profile and bioactivity. S.E. Volker, J. 

Freeman, G. Banuelos and E.H. Jeffery. Univ. of Illinois at 

Urbana-Champaign and USDA, Parlier, CA. 

A152 I 928.19 Structure-activity relationships of 

(1′S)-acetoxychavicol acetate for the decrease in intracellular 

glutathione level in Ehrlich ascites tumor cells. I. Matusi-Yuasa, 

S. Xu, A. Kojima-Yuasa, H. Azuma and D.O. Kennedy. Grad. 

Sch. of Human Life Sci. and Grad. Sch. of Engin., Osaka City 

Univ., Japan. 

A153 II 928.20 Fatty acid and retinoid modulation of 

breast cancer progression. S.N. Hawk and D. Brown. Central 

Washington Univ. and California Polytech State Univ. , San Luis 

Obispo. 


A154 I 928.21 Probiotic lactobacilli decrease 

invasion of metastatic human colon cancer cells in vitro. J. 

Escamilla, M.A. Lane and V. Maitin. Texas State Univ. 

A155 II 928.22 Dark chocolates suppress rat aberrant 

crypt foci formation by downregulation of inflammation involved 

gene expression. E. DeIulio and M.Y. Hong. San Diego State 

Univ. 

A156 I 928.23 The effects of the extract of Rubaiyat, 

an Oklahoma grape variety, and resveratrol on cellular 

proliferation and apoptosis of MCF-7 human breast cancer 

cells. E. Luebcke, S. Peterson, E. Stafne, S. Clarke, A. Basu, 

B. Smith and E. Lucas. Oklahoma State Univ. 

A157 II 928.24 Zinc supplementation protects THP-1 

cells against etoposide-induced apoptosis through promoting 

metallothionein expression. Z. Xu and M. Purtzki. Univ. of 

British Columbia. 

A158 I 928.25 Zinc depletion-induced apoptosis in 

human breast cancer MDA-MB-231 cells is calcium-dependent. 

Z. Xu and M. Purtzki. Univ. of British Columbia. 

A159 II 928.26 The effects of talosin A on the 

proliferation of breast cancer cells and RANKL-OPG expression 

in osteoblasts. S-C. Kang, N-S. Kang, S. Pyo and E-H. Sohn. 

Semyung Univ., Col. of Pharm., Sungkyunkwan Univ.and 


929. Translational and Clinical Aspect of 

Diet and Cancer 

Poster 



A160 I 929.1 Oral amino acids and testosterone 

therapy to improve muscle mass and quality of life during 

chemotherapy in recurrent cervical cancer: a case study. E.L. 

Dillon, K.M. Randolph, S.L. Casperson, W.J. Durham, R.J. 

Urban, L. Levine, C. Diaz-Arrastia and M. Sheffield-Moore. 

Univ. of Texas Med. Branch. 

A161 II 929.2 Association between serum cytokine 

concentrations, flavonol intake and colorectal adenoma 

recurrence in the polyp prevention trial. G. Bobe, G. Murphy, 

P.S. Albert, L.B. Sansbury, A. Schatzkin, E. Lanza, N.H. 

Colburn and A.J. Cross. Oregon State Univ., NCI-Frederick 

and NCI and NICHD, NIH, Bethesda. 

A162 I 929.3 Sulforaphane absorption and excretion 

from fresh broccoli sprouts and a semi-purified broccoli powder 

rich in glucoraphanin in healthy men. J.M. Cramer and E.H. 

Jeffery. Univ. of Illinois at Urbana-Champaign. 

A163 II 929.4 Anorexia in patients with smell loss 

(hyposmia) corrected by treatment with intranasal theophylline. 

R.I. Henkin, V. Gouliouk, M. Schultz and L. Minnick. Taste 

and Smell Clin., Washington, DC, Fndn. Care LLC, Earth City, 

MO and St. Louis Col. of Pharm. 

A164 I 929.5 Effect of Opuntia ficus-indica extract 

on anti-inflammatory in murine macrophages. J. Jung and 

J.H. Shin. Sookmyung Womenn’s Univ. and Joongbu Univ., 


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930. Nutrition and Cancer Survivorship 

Poster 



A165 I 930.1 Dietary intakes in pediatric patients 

with acute lymphoblastic leukemia during chemotherapy. S. 

Chatvuttinun, P. Phoonlapdacha, U. Suthutvoravut and 

N. Chongviriyaphan. Ramathibodi Hosp., Mahidol Univ., 

Thailand. 

A166 II 930.2 Binding of DNnp63 to the promoter 

of p21, a p53-dependent cell cycle arrest gene, modifies the 

response of salivary glands to therapeutic radiation. G.C. 

Mitchell, J.L. Fillinger, J.L. Avila, K.R. Victory and K.H. 

Limesand. Univ. of Arizona. 

A167 I 930.3 IGF1 prevents radiation-induced 

salivary gland dysfunction which does not affect survival of 

head and neck tumors. K.R. Victory and K.H. Limesand. Univ. 

of Arizona. 

A168 II 930.4 Restoration of radiation therapyinduced 

salivary gland dysfunction by post therapy IGF1 

administration. K.H. Limesand, O. Grundmann, J.L. Fillinger 

and K.R. Victory. Univ. of Arizona. 

A169 I 930.5 The association between serum folate 

and folate sub-species with overall survival after breast cancer 

diagnosis. A.J. McEligot, A. Ziogas and H. Anton-Culver. 

California State Univ., Fullerton and Univ. of California, Irvine. 

931. Obesity, Inflammation, and Cancer Risk 

Poster 



A170 I 931.1 Dietary oleanolic acid suppresses 

adipocyte differentiation and expression of proinflammatory 

visfatin. H-Y. Sung, J. Li, S-W. Kang, J-L. Kim, D.S. Kim and 

Y-H. Kang. Hallym Univ., Republic of Korea. 

A171 II 931.2 Adiponectin and body weight regulate 

colon cancer tumorigenesis in obese mice. R.L. Boddicker, E. 

Whitley, M. Nilsen-Hamilton, D.F. Birt and M.E. Spurlock. 

Iowa State Univ. 

A172 I 931.3 NG2 expression in mammary gland 

and DMBA-induced tumor of obese Zucker rat model. B.M. 

Karbassi, S. Korourian, C.H. Jo and R. Hakkak. Univ. of 

Arkansas for Med. Sci. 

A173 II 931.4 A legume-enriched diet facilitates 

weight loss and improves biomarkers of insulin resistance and 

inflammation. Z. Zhang, E. Lanza, D. Mitchell, R. Mentor- 

Marcel, N. Colburn and T. Hartman. Penn State and NCI- 

Frederick. 

A174 I 931.5 Obesity and prostate cancer 

aggressiveness among African and Caucasian Americans. 

L.J. Su, L. Arab, S. Steck, J.C. Schroeder, E.T.H. Fontham, 

J.T. Bensen and J.L. Mohler. NCI, NIH, UCLA, Univ. of South 

Carolina, NIEHS, NIH, Durham, LSU Hlth. Sci. Ctr., New 

Orleans, Univ. of North Carolina at Chapel Hill and Roswell 

Park Cancer Inst. 

A175 II 931.6 Mining serum for a lipolysis factor. 

L.O. Byerley and M. Lively. LSU Hlth. Sci. Ctr., New Orleans 

and Wake Forest Univ. Sch. of Med. 

Nutrition 

A176 I 931.7 Adipocity-associated plasma 

biomarkers in breast cancer patients and their relationship 

with dietary nutrient intake and BMI. J-y. Yeon, J-s. Kim and 

M-K. Sung. Sookmyung Women’s Univ. and Natl. Cancer Ctr., 

Gyeonggi-do, Republic of Korea. 

A177 II 931.8 High-fat diet induced obesity 

accelerates colon tumor formation in AJ and ICR mice. S-Y. 

Park, J-S. Kim, Y-R. Seo and M-K. Sung. Sookmyung Women’s 

Univ., Kyungpook Natl. Univ. and Kyunghee Univ., Republic of 

Korea. 

A178 I 931.9 Peroxisome proliferator-activated 

receptor-gamma ligand suppressed leptin-mediated expression 

of interleukin-8 and tumor angiogenesis in human colon cancer 

cells. F-Y. Wang and F-Y. Tang. China Med. Univ., Taiwan. 

932. Obesity, Diabetes, and Metabolic Risk 

Poster 



A179 I 932.1 A systematic review of the separate 

and combined effects of energy restriction and exercise on 

fat-free mass in middle-aged and older adults: implications 

for sarcopenic obesity. E. Weinheimer, L.P. Sands and W.W. 

Campbell. Purdue Univ. 

A180 II 932.2 Carbohydrate intake is associated 

with diet quality in patients with type 2 diabetes. J-Y. Hwang, 

J.E. Park, S.J. Kim, Y.J. Choi, K.B. Huh, N. Chang and W.Y. 

Kim. Ewha Womans Univ., Republic of Korea and 21C Diabet. 

and Vasc. Res. Ctr., Seoul. 

A181 I 932.3 Dietary patterns of Korean patients 

with type 2 diabetes and their relation to risk factors of diabetic 

complications. J-Y. Hwang, Y.J. Lee, S.J. Kim, N. Chang and 

W.Y. Kim. Ewha Womans Univ., Republic of Korea. 

A182 II 932.4 The relationship between 

microalbuminuria and glycemic control in Haitian Americans 

with type 2 diabetes. G.G. Zarini and F.G. Huffman. Florida 

Intl. Univ. 

A183 I 932.5 Understanding the differences in 

pulse pressure in two minority groups: Haitians and Cubans. 

F.G. Huffman, G.G. Zarini, J.C. Exebio, E. Nelson, N. Pinzon, 

J. Negron, V. Morgan and N.R. Ortiz. Florida Intl. Univ. 

A184 II 932.6 Acculturation, diabetes selfmanagement, 

Cuban Americans. J.A. Vaccaro, D. Gundupalli, 

Z. Dixon and F.G. Huffman. Florida Intl. Univ. 

A185 I 932.7 Effect of family support and education 

on diabetes self management in Cuban Americans. D.P. 

Gundupalli, J. Vaccaro and F.G. Huffman. Florida Intl. Univ. 

A186 II 932.8 Use of HbA 1c 

in screening for Cuban- 

Americans with undiagnosed type 2 diabetes. J.C. Exebio, 

G.G. Zarini, C. Exebio and F.G. Huffman. Florida Intl. Univ. 

and Univ. Privada Antenor Orrego, Peru. 

A187 I 932.9 Comparison of vitamin D status in 

Cuban-Americans with and without type 2 diabetes. J.P. Liuzzi, 

H.P. Modi, G.G. Zarini and F.G. Huffman. Florida Intl. Univ. 

A188 II 932.10 Antiobesity effects of foeniculum 

fructus water extracts in high fat diet-induced obese mice. J.M. 

Baek, M.J. Chung, D.J. Kim, D.J. Seo, J.K. You, T.H. Kim and 

M. Choe. Kangwon Natl. Univ., Republic of Korea. 

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A189 I 932.11 A study on the glucose-regulating 

enzyme activities of water extracts from Korea medicinal 

herbs of HepG2 in hyperglycemic conditions. D.J. Kim, M.J. 

Chung, D.J. Seo, J.K. You, J.M. Baek, J.M. Kim and M. Choe. 


A190 II 932.12 Effects of Foeniculum fructus and 

mixture water extracts on activities of key enzymes on lipid 

metabolism. D.J. Kim, M.J. Chung, D.J. Seo, J.K. You, T.H. 

Kim, J.M. Baek and M. Choe. Kangwon Natl. Univ. and 

Nutraceut. Bio Brain Korea 21 Project Gp., Chuncheon, 


933. The Metabolic Syndrome: Measurement 

Issues and Their Effects on Health 

Outcomes 

Poster 



A191 I 933.1 Waist circumference was not better in 

identifying individuals at risk for metabolic disorders than BMI 

among Koreans. S-K. Lee. Inha Univ., Republic of Korea. 

A192 II 933.2 Metabolic syndrome in healthy, 

multiethnic adolescents in Toronto: the use of fasting blood 

glucose as a simple indicator. V. Vuksan, A. Rogovik, V. Peeva, 

U. Beljan-Zdravkovic, M. Stavro, A. Jenkins, A. Dias, S. 

Devanesen, C. Fairgrieve and A. Hanna. St. Michael’s Hosp. 

and Univ. of Toronto. 

A193 I 933.3 Metabolic syndrome risk is associated 

with lower cardiovascular fitness and daily activity levels among 

young adults. J.S. Morrell, T.J. Quinn, G.B. Carey, R.A. Reilly 

and J.D. Burke. Univ. of New Hampshire. 

934. Obesity and the Metabolic Syndrome: 

Liver and Muscle 

Poster 



A194 I 934.1 A mouse model for nonalcoholic 

steatohepatitis. S. Sundaresan, P. Vijayagopal, N. Mills, V. 

Imrhan and C. Prasad. Texas Woman’s Univ. 

A195 II 934.2 High-fat diet with adequate methionine 

and choline levels induces hepatic insulin resistance via 

Akt signaling pathway in a rodent model for nonalcoholic 

steatohepatitis. S. Sundaresan, P. Vijayagopal, N. Mills, V. 

Imrhan and C. Prasad. Texas Woman’s Univ. 

A196 I 934.3 Improved obesity-induced insulin 

resistance in mice lacking tumor progression locus 2. Y. Lee, 

J.W. Perfield, E. Chang, S. Hussain, C. Xie, P.N. Tsichlis, 

M.S. Obin and A.S. Greenberg. USDA at Tufts Univ., Univ. of 

Missour-Columbia and Sch. of Med., Tufts Med. Ctr. 

A197 II 934.4 Obese canine skeletal muscle 

transcriptome exhibits altered inflammatory signaling. R.W. 

Grant, B.M. Vester Boler, T.K. Ridge, T.K. Graves and K.S. 

Swanson. Univ. of Illinois at Urbana-Champaign. 


935. Obesity and the Metabolic Syndrome 

Poster 



A198 I 935.1 Prevalence of metabolic syndrome in 

young adults in a historically black college setting. A.M. Tope 

and P.F. Rogers. Kentucky State Univ. 

A199 II 935.2 Metabolic risk of obese middle school 

students in Korea. J. Koo and K.J. Jang. Korea Natl. Open 

Univ. 

A200 I 935.3 Blood pressure is associated with BMI 

and predicts plasma glucose control and triglycerides among 

obese Latinos with type 2 diabetes. J. Chhabra, S. Vega- 

López, D. D’Agostino, M.L. Fernandes, S. Segura-Pérez, G. 

Damio and R. Pérez-Escamilla. Hartford Hosp., Arizona State 

Univ., Univ. of North Texas Hlth. Sci. Ctr.,Univ. of Connecticut, 

Hispanic Hlth. Council, Hartford and Yale Sch. of Publ. Hlth. 

A201 II 935.4 Body fat correlates with metabolic 

and inflammatory markers in clinically healthy obese Mexican 

subjects. M. Kaufer-Horwitz, K.I. Valencia-Barragán, R. 

Saldaña and F.E. Gómez. Natl. Inst. of Med. Sci. and Nutr. 

Salvador Zubirán, Mexico City. 

A202 I 935.5 Adipocity-related chemokines as 

early biomarkers of metabolic syndrome in Korean adults. Y-J. 

Bae, S-H. Kim, J-H. Chung, K-S. Kim, O-R. Kwon, M-K. Kim 

and M-K. Sung. Sookmyung Women’s Univ., Catholic Univ. of 

Korea and Ewha Womans Univ., Republic of Korea. 

A203 II 935.6 Relationship between elevated 

serum alanine aminotransferase concentration and metabolic 

syndrome in Korean adults. J. Kim. Daegu Univ., Republic of 

Korea. 

A204 I 935.7 The elevated serum monocyte 

chemoattractant protein-1 in obesity is influenced by parathyroid 

hormone and not body mass index. D. Sukumar, N. Partridge, 

X. Wang and S. Shapses. Rutgers Univ., NYU and UMDNJ, 

New Brunswick. 

936. Obesity II 

Poster 



A205 I 936.1 Impact of adherence to new IOM 

weight gain guidelines on birth outcomes among obese 

pregnant women. D. Castaneda, J. De Haene, M. Perez, N. 

Stotland, E. Murphy and J.C. King. Children’s Hosp. Oakland 

Res. Inst. and UCSF, San Francisco Gen. Hosp. 

A206 II 936.2 Omega-3 fatty acid consumption of 

lean and obese children ages 8 to 11 living in a community 

near the east coast of the United States . K. Heidal, R.C. 

Hickner, C.J. Tanner, P. Brophy, B. Schmitt and M. Piland. 

East Carolina Univ. 

A207 I 936.3 Extreme childhood obesity and risk 

for gastroesophageal reflux disease. C. Koebnick, D. Getahun, 

N. Smith, A.H. Porter, J. DerSarkissian and S.J. Jacobsen. 

Kaiser Permanente Southern California, Pasadena, Baldwin 

Park and Los angeles. 

A208 II 936.4 Influence of marketing on 

preschoolers’ product preference. S.E. Colby, J. Bulova, A. 

Person and V. Carraway-Stage. East Carolina Univ. 

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A209 I 936.5 Suppressed cytokine production 

in whole blood culture is partially corrected following weight 

reduction in morbidly obese women. L. Tussing-Humphreys, 

C. Braunschweig, M. Pini and G. Fantuzzi. USDA, Baton 

Rouge and Univ. of Illinois at Chicago. 

A210 II 936.6 The effect of corn gluten hydrolysates 

containing high leucine on weight reduction in diet-induced 

obese rats. H. Bong, M.S. Moon, S. Hong and O. Kwon. Ewha 

Womans Univ., Republic of Korea. 

A211 I 936.7 Hormonal and body composition 

changes associated with amelioration of diet-induced obesity 

by deoxynivalenol in the mouse. K. Hattori, B. Flannery, C. 

Amuzie and J. Pestka. Michigan State niv. and Tokyo Univ. of 

Agr. 

A212 II 936.8 The Fat Suit Study: when skinny 

companions lead us to eat healthier. M. Shimizu, L.E. Smith 

and B. Wansink. Cornell Univ. 

A213 I 936.9 Anti-obesity effect of Blumea 

balsamifera extract in 3T3-L1 preadipocytes and adipocytes. 

A. Kojima-Yuasa, H. Kubota and I. Matsui-Yuasa. Grad. Sch. 

of Human Life Sci., Osaka City Univ. 

A214 II 936.10 Anthropometric parameters of 

personnel who attend the nutrition clinic at Universidad 

Iberoamericana (Mexico City). A. Suverza-Fernández, K. 

Haua, C. Villegas, K. Loza-Hirasaka, G. Bilbao and A.B. 

Pérez-Lizaur. Univ Iberoamericana, Mexico. 

A215 I 936.11 Influence of dietary fatty acid content 

and composition on lipid metabolism in the Syrian hamsters. 

A.H. Keenan, B.J. Belda, W.R. Keyes and J.W. Newman. 

Univ. of California, Davis and USDA, Davis. 

A216 II 936.12 Adherence self-perception and 

weight and fat loss in the nutrition clinic at the Universidad 

Iberoamericana Mexico. A.B. Pérez-Lizaur, I. Gomez, T. 

Velasco, A. Zárate, C. Masliah and M. García Campos. Univ. 

Iberoamericana, Mexico. 

A217 I 936.13 Sub-chronic effects of orally ingested 

liquid dietary supplement, TAIslim ® containing a combination 

of soluble dietary fiber, phenylalanine, N-acetyltyrosine, tea 

polyphenols with caffeine and Lycium barbarum on body weight 

and other anthropom H. Amagase and R. Handel. FreeLife 

Intl., Phoenix. 

A218 II 936.14 Convenience stores are associated 

with early childhood obesity in low-income households. M. 

Koleilat, G. Harrison, S. Whaley, J. Gomez and E. Jenks. 

UCLA and Publ. Hlth. Fndn. Enterprises WIC Prog., Irwindale, 

CA. 

A219 I 936.15 Perceived determinants of childhood 

obesity among WIC participants. M.A. Mejia, S.B. Montgomery 

and H. Melgar-Quinonez. Andrews Univ., Loma Linda Univ. 

and Ohio State Univ. 

A220 II 936.16 Psychological factor changes during 

a randomized trial of legume consumption during weight loss. 

E.A. Murphy, J.C. Lovejoy, P.A. Palmer, P.E. Eichelsdoerfer, 

M.M. Gehrke, I.T. Kavanaugh and M.A. McCrory. Purdue 

Univ., Free & Clear, Seattle and Bastyr Univ. 

937. Lipid and Fatty Acid Metabolism and 

Transport II 

Poster 

Nutrition 



A221 I 937.1 Erythrocytes fatty acid composition and 

dietary intakes are correlated with markers of atherosclerosis 

in patients with myocardial infarction. Y. Park. Hanyang Univ., 


A222 II 937.2 The expression of enzymes related 

to reverse cholesterol transport metabolism in metabolic 

syndrome: KMSRI-Seoul project. M.Y. Park, I.H. Kang, S.Y. 

Lee, K.M. Park and M.S. Lee. SungShin Women’s Univ., 


A223 I 937.3 Branched chain fatty acids are taken 

up and metabolized by cultured human intestinal cells (Caco- 

2). R.R. Ran-Ressler, K.S.D. Kothapalli, R.P. Glahn and J.T. 

Brenna. Cornell Univ. and USDA, Ithaca. 

A224 II 937.4 Dietary LCPUFA upregulate FADS3 

alternative transcripts in neonatal baboon liver. H.T. Reardon, 

W.J. Park, K.S.D. Kothapalli and J.T. Brenna. Cornell Univ. 

A225 I 937.5 Soy protein regulates differently 

reverse cholesterol transport in liver and ileum in mice. O. 

Granados, M. Gonzalez-Granillo, N. Torres and A.R. Tovar. 

Natl. Inst. of Med. Sci. and Nutr. Salvador Zubirán, Mexico City. 

A226 II 937.6 A high fructose diet affects synthesis 

and composition of fatty acids in the liver of lactating dams and 

body of their suckling pups. V. Douard, J. Mourot, S. Shapses 

and R. Ferraris. UMDNJ-New Jersey Med. Sch., INRA, St. 

Gilles, France and Rutgers Univ. 

A227 I 937.7 The effect of altering n-6:n-3 ratio 

using plant and marine sources of n-3 fatty acids on biomarkers 

of bone turnover. S. Rajaram, L. Nguyen, S. Mohan, K. Oda 

and J. Sabaté. Loma Linda Univ. and Jerry L. Pettis VA Med. 

Ctr. 

938. Dietary Factors Affecting Lipid 

Metabolism II 

Poster 



A228 I 938.1 The dose response effects of lean 

beef on LDL-C change: results from the Beef in an Optimal 

Lean Diet Study. M.A. Roussell, T. Gaugler, S. West, J. Vanden 

Heuvel and P.M. Kris-Etherton. Penn State. 

A229 II 938.2 Lipids profile after consumption of 

different types of vegetable oils: a pilot test in rats. G. Gaona, 

P. Reyes, R. Delgado, A. Montañez, R.A. Ferriz, M.C. 

Caamaño, M.A. Anaya, O.P. García, J.L. Rosado, T. García 

and K. de la Torre-Carbot. Autonomous Univ. of Querétaro 

and Autonomous Univ. of Aguascalientes, Mexico. 

A230 I 938.3 High-fat diet: effects on serum lipid 

profile in an experimental model. P.D. Perris, M.S. Feliu, I. 

Fernandez and N. Slobodianik. Sch. of Nutr., Univ. of Buenos 

Aires. 

A231 II 938.4 Consumption of high-oleic peanuts 

reduces LDL cholesterol in golden Syrian hamsters. N.F. Shay, 

B. Tillman and D.W. Gorbet. Univ. of Florida, Gainesville and 

Marianna. 

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A232 I 938.5 A very low carbohydrate diet and 

increased physical activity improve LDL particle size in 

individuals taking statins. E.E. Quann, K.D. Ballard, B.R. 

Kupchak, C.M. Maresh, W.J. Kraemer, M.L. Fernandez, R.L. 

Seip and J.S. Volek. Univ. of Connecticut. 

A233 II 938.6 A Mediterranean-style low glycemic 

load diet reduces LDL oxidation and lipoprotein (a) in women 

classified with the metabolic syndrome. M.V. Comperatore, C. 

Andersen, J. Jones, R.H. Lerman and M.L. Fernandez. Univ. 

of Connecticut and MetaProteomics LLC, Gig Harbor, WA. 

A234 I 938.7 Effects of consuming a yogurt 

containing plant sterols, as part of a therapeutic lifestyle 

changes diet, on blood lipids in men and women with primary 

hypercholesterolemia. S.S. Jonnalagadda, K.C. Maki, M.S. 

Reeves, T.M. Rains and M. Witchger. General Mills, Golden 

Valley, MN and Provident Clin. Res., Bloomington, IN. 

A235 II 938.8 A Mediterranean-style low glycemic 

load diet decreases the risk for heart disease by decreasing 

atherogenic lipoproteins: addition of a medical food containing 

has a more favorable effect on LDL metabolism. J. Jones, J. 

Barona, M. Calle, R. Lerman, M. McIntosh, C. Kalynych, C. 

Vukich, J.S. Volek and M.L. Fernandez. Univ. of Connecticut, 

MetaProteomics LLC, Gig Harbor, WA and Univ. of Florida, 

Jacksonville. 

A236 I 938.9 Low density lipoprotein quantification: 

a new look. M. Schlegl-Zawadzka and J. Hartwich. Jagiellonian 

Univ. Med. Col., Poland. 

A237 II 938.10 Effects of vitamin B6 deficiency on 

lipid metabolism in HepG2 cells. M. Zhao, V. da Silva, M. Ralat 

and J.F. Gregory. Univ. of Florida. 

A238 I 938.11 A high fat diet reduces the expression 

of lipogenic, lipolytic and oxidative genes in white adipose 

tissue: the effect of the concentration and type of fatty acid 

is dependent of the dietary protein. A. Diaz-Villaseñor, B. 

Palacios-Gonzalez, C. Tovar-Palacio, A.R. Tovar and N. 

Torres. Natl. Inst. of Med. Sci. and Nutr. Salvador Zubirán, 

Mexico City. 

A239 II 938.12 Effect of dietary fatty acids on lipid 

profile and gene expression in blood, skeletal muscle, adipose, 

liver and intestine. E.D. Jesch, Z. Wang, P.N. Black and C.C. 

DiRusso. Univ. of Nebraska-Lincoln. 

A240 I 938.13 The type and amount of dietary fat and 

time of consumption alters hepatic lipogenesis and oxidation: 

role of PGC1b. G. Ordaz-Nava, N. Cruz-Salazar, N.E. Lara- 

Pompa, A.R. Tovar and N. Torres. Natl. Inst. of Med. Sci. and 

Nutr. Salvador Zubirán , Mexico City. 

A241 II 938.14 Effect of fish oil supplementation on 

mammary lipogenesis in mice. M. Hussein, K.J. Harvatine, 

Y.R. Boisclair and D.E. Bauman. Cornell Univ. and Penn 

State. 

939. Polyunsaturated Fatty Acids and 

Health II 

Poster 



A242 I 939.1 Flaxseed oil and vitamin K effect on 

turkey bone mineralization and strength. B.E. Newell, R.S. 

Smith, N.P. Johnston and R.T. Davidson. Brigham Young 

Univ. 


A243 II 939.2 Correlation between n-3 fatty acid 

intakes estimated using a food frequency questionnaire and 

concentrations measured in plasma phospholipids. V. Garneau, 

A-M. Paradis, G. Godin, P. Julien, L. Perusse and M-C. Vohl. 

Laval Univ., Canada. 

A244 I 939.3 Inhibition of collagen-mediated 

platelet reactivity in response to high doses of polyunsaturated 

omega-3 fatty acids. J.M. Anderson-Daniels, E.L. Graslie, J. 

Tholen, J.H. Ashmore, A.J. Korth, G.C. Shearer, W.S. Harris 

and M.K. Larson. Augustana Col. and Univ. of South Dakota. 

A245 II 939.4 Stearidonic acid-enriched soybean 

oil as an effective source of long-chain polyunsaturated fat in 

foods. S. Lemke, R. Wilkes, D. Welsby, D. Goldstein, E. Krul, 

R. Mukherjea and W.S. Harris. Monsanto Co., Solae LLC, St. 

Louis and Sanford Res./Univ. of South Dakota. 

A246 I 939.5 Differences in maternal serum 

fatty acid composition and dietary fat intake in women with 

gestational diabetes or mild gestational hyperglycemia. X. 

Chen, T.O. Scholl, M. Leskiw, J. Savaille and T.P. Stein. 

UMDNJ-Sch. of Osteo. Med. 

A247 II 939.6 Fatty acids of plasma phospholipids 

and erythrocytes are reliable biomarkers of n-3 polyunsaturated 

fatty acid supplementation. I. Rudkowska, M. Plourde, P. 

Julien, S. Lemieux, P. Couture and M-C. Vohl. CHUL Res. 

Ctr. and Nutraceut. and Funct. Foods Inst., Quebec City. 

A248 I 939.7 The influence of diets differing in 

polyunsaturated fatty acids on renal function in female rats. J. 

Gigliotti, R.E. Lukas, A.L. Smith and J.C. Tou. West Virginia 

Univ. 

A249 II 939.8 Lipidemic and cholesterolemic effects 

of feeding an algal source of docosahexaenoic acid to mice. 

R.A. Pietrofesa and K.M. Barnes. West Virginia Univ. 

A250 I 939.9 Docosahexanoic acid intake from 

food and supplement sources of pregnant women living in a 

non-coastal community. C.G. Campbell and R. Filipowicz. 


A251 II 939.10 The expression of tetranectin is 

affected by polyunsaturated fatty acids in human adipocytes. 

Y-C. Wang, H-T. Wu, H-Y. Lin and S-T. Ding. Natl. Taiwan 

Univ. 

A252 I 939.11 The synergistic effect of calcium, 

alpha-linolenic acid and conjugated-linoleic acid on 

osteoblastogenesis and adipogenesis. Y. Kim, O.J. Kelly and 

J.Z. Ilich. Florida State Univ. and Texas Woman’s Univ. 

A253 II 939.12 Effect of omega-3 fatty acid 

supplementation on indicators of membrane fluidity. A. 

Carughi, L.T. Huynh and D. Perelman. Hlth. Res. & Studies 

Ctr., Atherton, CA and GNLD Intl., Fremont, CA. 

A254 I 939.13 The modulation of intestinal endotoxin 

transport by different dietary fats. V. Mani and N.K. Gabler. 


A255 II 939.14 Endocannabinoid system expression 

in osteoblast-like cells is influenced by differentiation and 

eicosapentaenoic acid treatment. H.L. Hutchins , Y. Li, K. 

Hannon and B.A. Watkins. Purdue Univ. 

A256 I 939.15 Omega-3 fatty acid concentrates 

dose dependently alter triglycerides and erythrocyte fatty 

acid composition with no effect on endothelial function. A.C. 

Skulas-Ray, P.M. Kris-Etherton, P.R. Wagner, W.S. Harris, 

L.F. Groves, W.J. Turbitt, M.D. Crispell, N. Poupin and S.G. 

West. Penn State, South Hills Sch. of Business and Technol., 

PA and Univ. of South Dakota. 

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A257 II 939.16 Prediction of biological docosahexanoic 

status using novel and traditional dietary assessment 

tools. R. Filipowicz, R. Foster and C. Campbell. Iowa State 

Univ. 

A258 I 939.17 Incorporation profiles of isomers 

of conjugated linoleic acids into raft and non-raft lipids of 

CHOcells. P.V. Subbaiah, I.G. Gould and S. Lal. Univ. of Illinois 

at Chicago. 

940. Nutrition Education II 

Poster 



A259 I 940.1 Educational modules created to teach 

freshman and senior year nutrition students about nutritional 

genomics were effective. C. Fang, K. Moltzen and C. Manning. 

Univ. of Delaware. 

A260 II 940.2 Nutritional status, knowledge about 

diet therapy according to age, education level in patients with 

type 2 diabetes in Korea. M. Doo, S-S. Cha and Y. Kim. Ewha 

Womans Univ., Republic of Korea. 

A261 I 940.3 Evaluation and implementation of 

nutrition competencies and a competency-based resource 

guide in preschool-aged children. R.E. Scherr, M. Brigss, H. 

Reed and S. Zidenberg-Cherr. Univ. of California, Davis and 

California Dept. of Educ., Sacramento. 

A262 II 940.4 Fast-food consumption among college 

students and their attitudes toward healthier fast-food options. 

C. Haines, C.E. O’Neil and M. Zanovec. Sch. of Human Ecol., 

LSU. 

A263 I 940.5 Assessment of the general nutrition 

knowledge level of medical students attending Sultan Qaboos 

University in Oman. M.I. Waly, Y. Al-Mukhaini and A. Ali. 

Sultan Qaboos Univ. and Hosp., Oman. 

A264 II 940.6 Teachers perceive California Nutrition 

Education Competencies, pre-Kindergarten through Grade 

Twelve as a useful framework for classroom instruction. M.M. 

Briggs, H. Reed and S. Zidenberg-Cherr. Univ. of California, 

Davis and California Dept.of Educ., Sacramento. 

A265 I 940.7 An evaluation of the California 

Instructional School Garden Program grants. E.L. Hazzard, 

E. Moreno, D.L. Beall and S. Zidenberg-Cherr. Univ. of 

California, Davis and California Dept. of Educ., Sacramento. 

A266 II 940.8 Garden-enhanced nutrition education 

improves nutrition knowledge and behavior in second-grade 

students. A. Jones, C. Ly, L. Wasilewski and S. Zidenberg- 

Cherr. Univ. of California, Davis and Get Healthy San Mateo 

County. 

A267 I 940.9 What is the minimal nutrition education 

dosage to achieve behavior change for SNAP-Ed participants 

A.C. Zubieta, C.A. Conway, J.A. Shertzer, J. Doyle Paddock 

and J. Dollahite. Ohio State Univ. and Cornell Univ. 

A268 II 940.10 A pilot study of paraprofessional peer 

teaching by teen moms in a teen parenting nutrition education 

program. S.S. Wong and S.D. Keller. Utah State Univ. and 

Women, Infants and Children Prog., Salt Lake City. 

Nutrition 

941. Tailoring Nutrition Education 

Intervention for Diverse Audiences 

Poster 



A269 I 941.1 Identification of food sources 

contributing to dietary quality in the Lower Mississippi Delta 

region: a systematic approach to designing dietary modifications 

for obesity prevention. S.J. Onufrak, C. Connell, J. Zoellner, 

J. Thomson, C. Champagne, M.L. Bogle and M.K. Yadrick. 

USDA, Stoneville, MS, Univ. of Southern Mississippi, USDA, 

Baton Rouge, Pennington Biomed. Res. Ctr. and USDA, Little 

Rock. 

A270 II 941.2 Endorsing healthier nutritional choices 

on a college campus: perceptions of and by student athlete 

endorsers. W.H. Ressler, W. Williams, M. Lindberg and R. 

McCabe. Ithaca Col. 

A271 I 941.3 Soul food or salsa: African American 

dietary patterns in the Sonaouthwest. S.V. Thompson, D.M. 

Winham and J.R. Wolven. Arizona State Univ., Mesa. 

A272 II 941.4 Individually tailored nutrition program 

is effective in improvement of chronic disease risk factors in 

worksite settings. H. Park, E. Kim, M. Hwang, Y-m. Paek, T-i. 

Choi and Y.K. Park. Kyung Hee Univ., Res. Inst. of Clin. Nutr., 

Seoul and Korea & Hydro Nuclear Power Co. Ltd., Seoul. 

A273 I 941.5 Ketogenic therapy education modules 

for caregivers and healthcare professionals. H. Allen, K. Lee, 

L. Jones, E. Andrade, P. Carney, Z. Liu and P.R. Borum. Univ. 

of Florida. 

A274 II 941.6 Nutrition intervention for adults with 

intellectual or developmental disabilities residing in group 

homes: MENU-AIDDs. K. Humphries, M.A. Traci and T.W. 

Seekins. Rural Inst. on Disabil., Univ. of Montana. 

942. Assessing Dietary Supplement Use and 

Data Base Issues 

Poster 



A275 I 942.1 A survey of micronutrient 

supplementation for patients with HIV. M.T. Greene and C.F. 

Tam. California State Univ., Los Angeles. 

A276 II 942.2 The Dietary Supplement Ingredient 

Database: comparison of adult and children’s multivitamin/ 

mineral products. K. Andrews, J. Roseland, A. Middleton, 

M. Feinberg, C. Zhao, J. Holden, J. Dwyer, M.F. Picciano, 

L. Saldanha, C. Sempos, R. Bailey and L. Douglass. USDA, 

Beltsville, MD, ODS, NIH and Consulting Statistician, Longmont, 

CO. 

A277 I 942.3 Use of dietary supplements by 

cardiologists, dermatologists and orthopedists: results of a 

survey. A. Dickinson, N. Boyon and A. Shao. Dickinson 

Consulting LLC, St. Paul, Ipsos Publ. Affairs, New York and 

Council for Responsible Nutr., Washington, DC. 

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A278 II 942.4 Iodine intake from dietary supplements 

among pregnant females in the U.S.: National Health 

and Nutrition Examination Survey 1999-2006. J. Gahche, R. 

Bailey, L. Mirel, J. Dwyer, R. Russell, C. Sempos and M.F. 

Picciano. Natl. Ctr. for Hlth. Stats., Hyattsville, MD and OD, 

NIH. 

A279 I 942.5 Survey of dietary supplement use 

in intercollegiate athletes. K.E. Vasaeli, L.J. Kruskall, K.S. 

Wilson and J.C. Young. Univ. of Nevada, Las Vegas. 

943. Applications, Benefits, Challenges 

of Public Use Data Set for Nutrition 

Research 

Poster 



A280 I 943.1 Discretionary energy, added sugars, 

and beverage choice by U.S. adults: results from What We Eat 

in America/NHANES 2005-2006. R. Sebastian, C. Wilkinson 

Enns, J.D. Goldman and A. Moshfegh. USDA, Beltsville, 

MD. 

A281 II 943.2 Converting food intakes to retail 

commodities: a novel approach to identify trends in food 

commodity usage by Americans. S. Bowman, C. Martin, J. 

Friday, A. Moshfegh and B-H. Lin. USDA, Beltsville, MD and 

Washington, DC. 

A282 I 943.3 Bone mineral density in U.S. adults 

in relation to urinary isoflavone excretion: secondary analysis 

using the National Nutrition and Health Examination Survey 

data. C.L. Frankenfeld. George Mason Univ. 

A283 II 943.4 Foodwiki: a distributed annotation 

system for building a nutrition and food database. P. Woolf, L. 

Fu and A. Basu. Foodwiki LLC, Ann Arbor. 

A284 I 943.5 The relationship between alcohol 

intake and mortality in Whites, Blacks and Hispanics using the 

NHIS mortality linked data set. E. Smit, C.T. Sempos, J. Rehm, 

N. Huguet and C.J. Crespo. Oregon State Univ., OD, NIH, Ctr. 

for Addiction and Ment. Hlth., Toronto and Portland State Univ. 

944. Trends in Dietary and Anthropometric 

Data for Special Populations II 

Poster 



A285 I 944.1 Correlations between dietary intake or 

body mass index and serum androgen in women with polycystic 

ovary syndrome. T-W. Wang, J.C-J. Chao, H-J. Wei, R. Young, 

C-M. Liaw, S-S. Wang, B-S. Jiang and H-J. Ho. Sch. of Nutr. 

and Hlth. Sci., Taipei Med. Univ., Taiwan and Taiwan Adventist 

Hosp., Taipei. 

A286 II 944.2 Differences in percent body fat and 

plant protein intake between females with and without polycystic 

ovary syndrome in South Korea. S-h. Park, J-Y. Hwang, N. 

Chang, H.W. Chung and Y-A. Sung. Ewha Womans Univ., 


A287 I 944.3 Dietary protein intake among adults in 

the United States and its relationship to select body composition 

measures. K.B. Parker, L.A. Berner and J. Doi. California 

Polytech State Univ., San Luis Obispo. 

A288 II 944.4 Dietary patterns affected the increase 

of bone mineral content in Korean girls. H.Y. Noh, Y. Song, 

M.K. Park, S.J. Li, H. Joung and H.Y. Paik. Seoul Natl. Univ., 

Sch. of Human Ecol., Catholic Univ. of Korea and JiLin Med. 

Col., People’s Republic of China. 

A289 I 944.5 An evaluation of the protein adequacy 

of typical U.S. vegetarian diets. C.S. Johnston and M. Williams. 

Arizona State Univ., Mesa. 

945. Measures of Diet and Their Association 

with Health Outcomes II 

Poster 



A290 I 945.1 Assessment of content validity and 

reliability of Institute of Functional Medicine Matrix Model, 

2008. S. Koutoubi, D. Boutin, M. Sasagawa, R.A. Crouse, 

M.G. Gill, A. Hoverter, M.R.M. Lesher, T.L. Mingione, J.M. 

Morgan, M.A. Rasmussen, M. Shurnene and S.E. Wells. 

Bastyr Univ. 

A291 II 945.2 Study on the blood profiles in patients 

with pulmonary tuberculosis during hospitalization period. J-Y. 

Kim, H. You and Y. Kim. Ewha Womans Univ., Republic of 

Korea. 

A292 I 945.3 Associations of obesity measures 

with consumption of regular/rich and light/fat-free ice cream 

served from multiple-serving packages or available as singleserving 

products: NHANES, 1999-2006. D.R. Keast, C. Kapica 

and D. Panyam. Food & Nutr. Database Res. Inc., Okemos, 

MI, Ketchum Inc., Chicago and Dreyer’s Grand Ice Cream Inc., 

Oakland, CA. 

A293 II 945.4 Decoupling the independent effects 

of multiple simultaneous behavior changes in weight loss. R.W. 

Patterson, C.R. Payne and B. Wansink. Cornell Univ. and 

New Mexico State Univ. 

A294 I 945.5 Caffeine intake and HIV viral burden 

in HIV + drug users in Miami. V. Ramamoorthy, A. Campa, S. 

Sales, Y. Li, D.T. Jayaweera, B.J. Page and M.K. Baum. R 

Stempel Col. of Publ. Hlth., Florida Intl. Univ. and Univ. of Miami 

Miller Sch. of Med. 

946. Osteoporosis, Nutrition, and Aging 

Poster 




A295 I 946.1 Varying dietary calcium, but not 

vitamin D, influences bone and calcium metabolism in mature 

mice. R.D. Schoch, J. Smolinski, R. McCreedy, S.K. Clinton 

and J.C. Fleet. Purdue Univ. and Ohio State Univ. 

A296 II 946.2 Resveratrol affects bone minerals 

and strength in aging hindlimb suspended rats. S. Wright, J.R. 

Jackson, M.J. Ryan, S.E. Alway and J.C. Tou. West Virginia 

Univ. 

286

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A297 I 946.3 Comparative effects of isoflavones 

and exercise on bone in hamsters. N. Bakhshalian, S.C. 

Campbell, S. Hooshmand, S.C. Chai and B.H. Arjmandi. 

Florida State Univ. 

A298 II 946.4 Effects of astragalus membranaceus 

supplementation with calcium on the bone mineral density and 

bone metabolism in Ca-deficient ovariectomized rats. H.J. Kim, 

S-C. Kang and M-H. Kim. Kangwon Natl. Univ. and Semyung 


A299 I 946.5 Anti-osteoporotic effects of silibinin 

and silymarin and on osteoblast differentiation and RANKLdependent 

osteoclast differentiation. J-L. Kim, J-S. Choi, S-M. 

Oh and Y-H. Kang. Hallym Univ., Republic of Korea. 

A300 II 946.6 Higher protein weight loss diet does 

not affect bone mineral density in a double-blind RCT in 

postmenopausal women. M.P. Thorpe, M.C. Mojtahedi, A.L. 

Richey, D.K. Layman and E.M. Evans. Univ. of Illinois at 

Urbana-Champaign. 

A301 I 946.7 Effect of plant and marine sources of 

n-3 fatty acids on markers of bone turnover in healthy adults. 

L. Nguyen, S. Rajaram, S. Mohan and J. Sabaté. Loma Linda 

Univ. and Jerry L. Pettis VA Med. Ctr. 

A302 II 946.8 Green tea polyphenols and Tai Chi 

exercise for postmenopausal osteopenic women: safety report 

from a 24-week placebo-controlled randomized trial. C-L. Shen, 

M-C. Chyu, J.K. Yeh, Y. Zhang, B.C. Pence, C.K. Felton, R.Y. 

Dagda, M. Dagda, S. Doctolero, M.J. Flores and J-S. Wang. 

Texas Tech Univ. Hlth. Sci. Ctr., Winthrop-Univ. Hosp., Mineola, 

NY and Univ. of Georgia. 

A303 I 946.9 Acidic diet and bone mineral content 

in older men: the CHAMP study. M. Heer, C. Chen, R.G. 

Cumming, M. Lichfield, V. Naganathan, F. Blyth, H. Creasey, 

L. Waite, D.J. Handelsman, D. Le Couteur, P. Sambrook 

and M.J. Seibel. Univ. of Sydney and German Aerospace Ctr. 

(DLR), Cologne. 

A304 II 946.10 Effects of duration of proton pump 

inhibitor therapy on markers of bone health in men and 

postmenopausal women. Z. Pabin, B.E. Newell, R. Richards, 

K.B. Franz and R.T. Davidson. Brigham Young Univ. 

A305 I 946.11 Association of bone mineral density, 

bone mineral content and serum lipids in Hispanics with type 2 

diabetes. E. Ojo, L. Beeson, I. Chukwueke, E. Shulz, A. Firek, 

M. DeLeon, H. Balcazar and Z. Cordero-MacIntyre. Loma 

Linda Univ. and Univ. of Texas Sch. of Publ. Hlth. at Houston. 

A306 II 946.12 Association of bone mineral density 

with lean mass and fat mass. S. Hooshmand, S.C. Chai, R.L. 

Saadat and B.H. Arjmandi. Florida State Univ. 

A307 I 946.13 Contribution of inflammatory markers 

to changes in bone in postmenopausal women: a 1-year 

investigation. E.R. Gertz, N. Silverman, K.S. Wise, J.W. 

Stewart, K.B. Hanson, D.L. Alekel and M.D. Van Loan. USDA 

and Univ. of California, Davis and Iowa State Univ. 

A308 II 946.14 Associations between bone quality 

and restrained eating, body weight, diet and physical activity 

in young adult Caucasian females. M. Zanovec and G. Tuuri. 

Sch. of Human Ecol., LSU AgCtr. 

A309 I 946.15 Association between risk perception 

and real fracture risk in adults. P. Clark, J. Tamayo, K. Haua, A. 

Suverza-Fernández and A.B. Pérez-Lizaur. Hosp. Infantil de 

México Federico Gomez, Osteosol and Univ. Iberoamericana, 

Mexico City. 

947. Community Nutrition and Aging II 

Poster 



A310 I 947.1 CordyMax extends the lifespan in an 

aging model: a preliminary report. N. Tan, Y. Zhang, J. Yang, 

C. Zhao and J-S. Zhu. Pharmanex Beijing Pharmacol. Ctr., 

Pharmanex Res. Inst., Provo, UT and Sch. of Pharm., Xinjiang 

Shihezi Univ., People’s Republic of China. 

A311 II 947.2 Anti-oxidation activities of CordyMax 

in an oxidative stress model: a mechanism of its anti-aging 

property. J. Yang, N. Tan, C. Zhao, Y. Zhang and J-S. Zhu. 

Pharmanex Beijing Pharmacol. Ctr., Pharmanex Res. Inst., 

Provo, UT and Xinjiang Shihezi Univ., People’s Republic of 

China. 

A312 I 947.3 Effect of natural plant water extracts 

suppressed melanin production in B16 mouse melanoma cell. 

T.H. Kim, M.J. Chung, D.J. Kim, J.K. You, D.J. Seo, J.M. Baek 

and M. Choe. Kangwon Natl. Univ., Republic of Korea. 

A313 II 947.4 Effect of natural plant water extracts 

suppressed melanin production in human skin cell(CCD-986sk). 

J.Y. Jang, M.J. Chung, J.K. You, D.J. Kim, D.J. Seo, T.H. Kim 

and M. Choe. Kangwon Natl. Univ., Republic of Korea. 

948. Environment and Diet in Aging 

Poster 



A314 I 948.1 Female rats fed low level whole 

cottonseed for life develop apparent brain neurofibrillary 

tangles. B.A. Semon. Wisconsin Inst. of Nutr., Milwaukee. 

A315 II 948.2 Diet restriction that improves longevity 

and health span also modifies gut microbiology. R.J. Martin, 

R.N. Senevirathne, M. Janes, V. Dixit and M.J. Keenan. LSU 

AgCtr. and Pennington Biomed. Res. Ctr. 

949. The Use of Consumer Insights and 

Understanding and Communicating 

Benefits of Natural State Foods 

Poster 

Nutrition 



A316 I 949.1 Benefits and barriers towards 

pulse consumption in physically active adults. G.A. Zello, 

C.B. Bennett, A.J. DesRoches and P.D. Chilibeck. Univ. of 

Saskatchewan. 

A317 II 949.2 Quality protein of Argentinean 

Northwest quinoa crops: study based on amino acids 

composition. S.M. Vidueiros, L. Dyner, D. Bertero and A. 

Pallaro. Sch. of Pharm. and Biochem. and Sch. of Agron., Univ. 

of Buenos Aires. 

A318 I 949.3 Do organic snack foods taste healthier 

because of their label J.W-C. Lee. Cornell Univ. 

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Pathology 

950. BioBanking 

Poster 


Presentation time: 11:30 a m-1:30 p m 

A323 950.1 Human biospecimens collection in the era 

of personalized medicine: challenges and perspectives. O. 

Potapova. Cureline Inc., Burlingame, CA. 

A324 950.2 Idiopathic pulmonary hypertension human 

tissue biobank. W.E. Grizzle, K.C. Sexton, R.M. Tuder, V.V. 

McLaughlin and S.B. Parker. Univ. of Alabama at Birmingham, 

Univ. of Colorado Denver, Aurora and Univ. of Michigan. 

951. Hemostasis 

Poster 



A325 951.1 Identification of a conformational epitope 

induced when plasminogen binds to fibrin. K-H. Kim, N. Baik, 

R.J. Parmer and L.A. Miles. The Scripps Res. Inst. and UCSD 

and VA San Diego Healthcare Syst. 

A326 951.2 von Willebrand factor and vWF propeptide 

are upregulated in heparin-induced thrombocytopenia. J.M. 

Walenga, D. Hoppensteadt, R. Davis, W. Jeske, V. Escalante, 

B. Conway and J. Fareed. Loyola Univ. Med. Ctr. and GTI 

Diagnostics, Waukesha, WI. 

A327 951.3 The role of V Leiden, prothrombin G20210A and 

C677T MTHFR mutations as risk factors for venous thrombosis 

and recurrent pregnancy loss. A. Al Thani, R. Badii, M. Al- 

Jaber, N. Almarii and S. Fahad. Qatar Univ. and Hamad Med. 

Corp., Qatar. 

A328 951.4 Biochip array analysis of various mediators 

of inflammation in disseminated intravascular coagulation. S. 

Rahman, D. Hoppensteadt, J. Cunanan, R. Davis, N. Sadeghi 

and J. Fareed. Loyola Univ. Med. Ctr. 

A329 951.5 Comparative studies on the USP reference 

standard over-sulfated chondroitin sulfate and two semisynthetic 

over-sulfated chondroitin sulfate preparations. N. 

Sadeghi, D. Hoppensteadt, O. Iqbal, W. Jeske, J.M. Walenga 


A330 951.6 Differential immunogenic responses of branded 

and generic versions of low molecular weight heparins. E. 

Ramaciotti, M. Gomez, J.M. Walenga, D. Hoppensteadt, G. 

Rao, H. Nader, W. Jeske and J. Fareed. Univ. of Michigan, 

Loyola Univ. Med. Ctr., Lillehei Heart Inst., Minneapolis and 

Fed. Univ. of São Paulo. 

A331 951.7 Comparative studies on branded dalteparin 

with two generic versions: hepagumin and fluzepamin. N. 

Sadeghi, D. Hoppensteadt, O. Iqbal, W. Jeske, J.M. Walenga 


A332 951.8 Potency adjustment of unfractionated heparins 

to harmonize the USP and WHO standardization: impact 

on anticoagulant practice in the U.S. D. Hoppensteadt, N. 

Sadeghi, O. Iqbal, R. Wahi, B. Lewis and J. Fareed. Loyola 

Univ. Med. Ctr. 

A333 951.9 Comparative studies on six unfractionated 

heparin batches from China. N. Sadeghi, D. Hoppensteadt, 

O. Iqbal, W. Jeske, J.M. Walenga and J. Fareed. Loyola Univ. 

Med. Ctr. 

A334 951.10 Different sources of over-sulfated chondroitin 

sulfate may produce differential interactions with heparins. A. 

Gray, D. Hoppensteadt, E. Litinas and J. Fareed. Loyola 


A335 951.11 Cross-reactivity of rabbit anti-bovine thrombin 

IgGs with a human plasma-derived thrombin preparation 

(Evithrom TM ). H. Zhu, D. Hoppensteadt, J. Cunanan and J. 

Fareed. Loyola Univ. Med. Ctr. 

A336 951.12 Increased microparticle procoagulant activity 

in mice lacking alpha(1,3)-fucosyltransferase-IV and –VII. H. 

Wang, M. Morales-Levy and J.W. Homeister. Univ. of North 

Carolina at Chapel Hill. 

A337 951.13 Elevated levels of circulating microparticles 

in disseminated intravascular coagulation and their impact 

on the inflammatory process. S. Rahman, M. Cichon, D. 

Hoppensteadt, J. Cunanan, W. Jeske and J. Fareed. Loyola 


A338 951.14 Effect of tamoxifen and raloxifene on platelet 

activation markers. Y. Dobrydneva and S.R. Vishneski. 

Eastern Virginia Med. Sch. 

A339 951.15 MBL-associated serine protease 1 is 

necessary for thrombin substrate cleavage in vitro. L.R. La 

Bonte, V. Pavlov, M. Takahashi, T. Fujita, K. Takahashi and 

G.L. Stahl. Harvard Med. Sch., Fukushima Med. Univ., Japan 

and Massachusetts Gen. Hosp. 

952. Mucosal Barriers and Host-Pathogen 

Defense 

Poster 



A340 952.1 Hepatocyte growth factor activator inhibitor 

type 1 is required for the integrity of intestinal epithelium. M. 

Kawaguchi, T. Fukushima, N. Takeda, S. Hoshiko, K. Yorita, 

K. Kohama, H. Orikawa, T. Baba and H. Kataoka. Univ. of 

Miyazaki and Univ. of Kumamoto, Japan. 

A341 952.2 Role of periostin in epithelial injury. T.A. Reaves, 

D.P. Lebel and J. Suber. Med. Univ. of South Carolina. 

A342 952.3 Effects of claudin overexpression in carcinoma 

cell lines. V.E. Zavala-Zendejas, A.C. Torres-Martínez, B. 

Salas-Morales and E.P. Rendon-Huerta. UNAM, Mexico 

City. 

A343 952.4 Yin and yang: CCL2 and IL-10 in otitis mediainduced 

inner ear inflammation. S.K. Moon, J-I. Woo, H. Pan, 

X. Li and D.J. Lim. House Ear Inst., Los Angeles and Univ. of 

Southern California. 

A344 952.5 Galectin-3 mediates chronic airway allergic 

inflammation and airway remodeling. X.N. Ge, N.S. Bahaie, 

B.N. Kang, R.M. Hosseinkhani, S.G. Ha, E.M. Frenzel, F-T. 

Liu, S.P. Rao and P. Sriramarao. Univ. of Minnesota, St. Paul 

and Univ. of California Davis, Sacramento. 

288

tuesday 

A345 952.6 Toll-like receptor 2 signaling pathway in lung 

injury. A. Jezierska, I.A. Kolosova and A.D. Verin. Med. Col. 

of Georgia and Bloomberg Sch. of Publ. Hlth., Johns Hopkins 

Univ. 

A346 952.7 Post-secretory activation of Paneth cell 

a-defensins in the cecal and colonic lumen of matrix 

metalloproteinase-7-null mice. J.R. Mastroianni, J.K. Costales, 

N.H. Salzman and A.J. Ouellette. USC Keck Sch. of Med. and 

Med. Col. of Wisconsin. 

A347 952.8 Diversity and activation of rhesus Paneth cell 

a-defensins. R.A. Llenado, A. Maemoto, M.T. Shanahan and 

A.J. Ouellette. Univ. of California, Irvine, Sapporo Higashi 

Tokusyukai Hosp., Japan, Univ. of North Carolina at Chapel Hill 

and USC Keck Sch. of Med. 

A348 952.9 Commensal-epithlial signaling mediated via 

formyl peptide receptor. C.C. Wentworth, R. Jones, A. Nusrat 

and A. Neish. Emory Univ. 

A349 952.10 Escherichia coli K1 induces the upregulation of 

CD47 in myeloid dendritic cells. R. Mittal and N.V. Prasadarao. 

Childrens Hosp. Los Angeles. 

A350 952.11 PKR regulates immunoglobulin class switching 

during RSV infection in vivo. S.A. Thakur, Z. Zalinger, T.R. 

Johnson, R.A. Corn Minor, B.S. Graham and F. Imani. 

NIEHS, NIH, Research Triangle Park and Bethesda and North 

Carolina A&T State Univ. 

A351 952.12 Bovine pituitary extract interferes with SARS- 

CoV replication. T. Jelesijevic, E. Uhl, F. Michel and R.J. 

Hogan. Univ. of Georgia Col. of Vet. Med. 

953. Role of Extracellular Matrix in 

Pathobiology 

Poster 



A352 953.1 Characterization of chondrocyte differentiation 

of ATDC5 cell line induced by ascorbic acid. T.M. Temu, C. 

Phornphtkul and P.G. Gruppuso. Warren Alpert Med. Sch., 

Brown Univ. 

A353 953.2 Changes in protein profile composition of 

coronary luminal membrane induced by ischemia and ischemia/ 

reperfusion. R. Rubio, B. Arroyo-Flores, A. Barba de la Rosa 

and M. Knabb. Autonomous Univ. of SLP and IPICYT, San 

Luis Potosi, Mexico and West Chester Univ. 

A354 953.3 Effect of trichostatin A on human diabetic 

fibroblast migration and matrix metalloproteinase expression. 

W.J. Lindblad. Husson Univ. Sch. of Pharm. 

A355 953.4 Fibrocytes express several matrix 

metalloproteinases: possible role in migration and homing. 

C. Garcia de Alba, C. Becerril, S. Reyes, M. Selman and 

A. Pardo. Natl. Inst. of Resp. Dis., Mexico City and Natl. 

Autonomous Univ. of Mexico. 

A356 953.5 Hyaluronan-chondrocyte interactions mediate 

cell signaling pathways. N. Luo, C.B. Knudson and W. 

Knudson. East Carolina Univ. 

A357 953.6 Rac1-mediated H 2 

O 2 

generation suppresses 

MMP-9 expression via ERK. S. Murthy and A.B. Carter. Univ. 

of Iowa. 

A358 953.7 Characterization of the opioid peptide 

dynorphin A as a novel ligand for leukocyte integrin a M 

b 2 

(Mac- 

1). J. Brothwell, N.P. Podolnikova and T.P. Ugarova. Sch. of 

Life Sci., Arizona State Univ. 

pathology 

954. Molecular Pathobiology of Neoplasia 

Poster 



A359 954.1 Cell phones as a new m-Health opportunity for 

mass cervical cancer screening. O. Markovic and N. Markovic. 

BioSciCon Inc., Rockville, MD. 

A360 954.2 MR angiogenesis imaging with Robo4- versus 

alphavbeta3-targeted nanoparticles in the B16/F10 mouse 

melanoma model. K. Boles, A. Schmieder, S. Caruthers, G. 

Hu, M. Scott, H. Zhang, B. Reynolds, S. Wickline and G. 

Lanza. Washington Univ. in St. Louis. 

A361 954.3 Molecular histology of tissue using imaging 

mass spectrometry and classification analysis. D.S. Cornett, 

K. Schwamborn, P. Wild and R.M. Caprioli. Bruker Daltonics, 

Billerica, MA,Vanderbilt Univ. and Univ. Hosp. Zurich. 

A362 954.4 Modern methods in histo- and cytopathology: 

a view from Russia. S.V. Jargin. Peoples’ Friendship Univ. of 

Russia. 

A363 954.5 An analysis of 1 year versus 3 month alphainterferon 

treatment in patients with melanoma stages IIB, 

IIC, and IIIA. A. Frankenthaler and M.B. Atkins. Beth Israel 

Deaconess Med. Ctr. and Union Col., NY. 

A364 954.6 Effect of cancer hereditary susceptibility on the 

prognosis of esophageal cancer patients from high esophageal 

cancer incidence area in China. X. Li, Z-M. Zhao, Y-Z. Zhang, 

F-Y. Zhou, X-H. Hou and H-L. Ji. Xinxiang Med. Univ., First 

People’s Hosp. of Zhengzhou, Tumor Hosp. of Anyang, Wuhan 

Union Hosp., Tongji Med. Col. of Huazhong Univ. of Sci. and 

Technol., People’s Republic of China and Univ. of Texas Hlth. 

Sci. Ctr. at Tyler. 

A365 954.7 P2 receptors and ATP enhance the migration 

of prostate cancer cells. W. Peters, R.A. Sikes, R. Duncan and 

C. Maguire. Lincoln Univ. and Univ. of Delaware. 

A366 954.8 Lysophosphatidic acid enhances VEGF-C 

expression in PC-3 human prostate cancer cells. C-e. Lin, C-H. 

Lin, C-L. Chang, Y-L. Huang and H. Lee. Natl. Taiwan Univ. 

A367 954.9 Sphingosine 1-phosphate-induced autophagy 

is mediated through activating endoplasmic reticulum stress 

response in human prostate cancer PC-3 cells. C-J. Shih, Y-L. 

Huang, C-L. Chang, W-P. Huang and H. Lee. Natl. Taiwan 

Univ. 

A368 954.10 The potential of conditionally replicating 

adenovirus expressing TIMP2 for ovarian cancer therapy. 

S. Yang, J.T. Douglas, R.D. Alvarez, G.P. Siegal and S. 

Ponnazhagan. Univ. of Alabama at Birmingham. 

A369 954.11 Oligonucleotide-based array CGH analysis of 

diffuse large B-cell lymphomas identifies gain of 7q22 as the 

most common genomic alteration. E.A. Medina, A.R. Bolla, 

R.L. Bandi and R.S. Robetorye. Univ. of Texas Hlth. Sci. Ctr. 

at San Antonio. 

A370 954.12 Epac1 is upregulated in chronic lymphocytic 

leukemic B cells. L. Brown, L. Zhang, T.J. Kipps and P.A. 

Insel. UCSD. 

A371 954.13 Bowel morphologic evaluation in a model of 

experimental intoxication with 1-naphtyl-N-methylcarbamate. 

K.P. Cavalcanti, I.A. Souza, R. Castro, N. Teles and A.S. 

Cabrita. Fac. of Med., Univ. of Coimbra, Portugal and Univ. 

Fed. of Pernambuco, Brazil. 

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pathology/Pharmacology 

A372 954.14 Bowel morphologic evaluation in experimental 

administration of wine and a pesticide. K.P. Cavalcanti, A.P. 

Gurgel, T. Mendes, P. Barreto, I.A. Souza, N.T. Filho and 

A.S. Cabrita. Fac. of Med., Univ. of Coimbra, Portugal and Fed. 

Univ. of Pernambuco, Brazil. 

A373 954.15 VEGF xxx 

b is relatively downregulated in 

malignant neuroblastoma but not in benign ganglioneuroma. 

M. Peiris, D.O. Bates and P. Ramani. Univ. of Bristol. 

A374 954.16 Low immunohistochemical expression of 

MGMT in ACTH secreting pituitary tumors of patients with 

Nelson syndrome. F. Salehi, B.W. Scheithauer, V.J. Moyes, 

W.M. Drake, L. Syro, B. Manoranjan, S. Sharma, E. Horvath 

and K. Kovacs. St. Michael’s Hosp., Univ. of Toronto, Mayo 

Clin., St. Bartholomew’s Hosp., London and Hosp. Pablo Tobon 

Uribe, Medellin, Colombia. 


A375 954.17 Immunoexpression of endoglin and CD-34 

in various human pituitary adenoma types. F. Rotondo, S. 

Sharma, B.W. Scheithauer, M. Cusimano and K. Kovacs. St. 

Michael’s Hosp., Univ. of Toronto and Mayo Clin. 

A376 954.18 Sensory dysesthesia: rare presentation of 

subependymoma. M. Kurukumbi, G. Ramidi, S. Samineni, A. 

Jayam-Trouth and A. Dabi. Howard Univ. Hosp. 

A377 954.19 The IKK inhibitor BMS345541 affects aurora 

kinase expression in human melanoma. R. Splittgerber, Y-J. 

Su, Y.M. Thu, D. Raman and A. Richmond. Vanderbilt Univ. 

Pharmacology and Experimental Therapeutics 

955. Vascular Function in Hypertension 

Poster 



C1 955.1 Adventitial infiltration of activated macrophages 

in mesenteric arteries of DOCA-salt rats. L.V. Thang and J.J. 

Galligan. Michigan State Univ. 

C2 955.2 Expression of Ang 1-7 receptor (MAS receptor) 

in aortic tissue during pregnancy-induced hypertension in rats. 

L. Anguiano-Robledo, M.A. Avila, B. Vazquez-Cruz and P. 

Lopez-Sanchez. Esc. Superior de Med.-IPN, Mexico City and 

FES Iztacala-UNAM, Mexico. 

C3 955.3 Renin/prorenin receptor decreased expression 

in heart during pregnancy-induced hypertension in rats. P. 

Lopez-Sanchez, E.M. Lopez, M.A. Avila and L. Anguiano- 

Robledo. Esc. Superior de Med.-IPN, Mexico City. 

C4 955.4 Expression of renin/prorenin receptor is 

decreased in vessels and kidney during pregnancy-induced 

hypertension in rats. R. Esteban, L. Anguiano-Robledo, J.A. 

Vela and P. Lopez-Sanchez. Esc. Superior de Med.-IPN, 

Mexico City. 

C5 955.5 Arterial function and flow related arterial 

remodeling during DOCA-salt hypertension. P. Lemkens, J. 

Nelissen, G.E. Fazzi, B.J.A. Janssen, J.G.R. De Mey and 

P.M.H. Schiffers. Maastricht Univ., Netherlands. 

C6 955.6 Increased catecholamine content and release 

from adrenal chromaffin cells of DOCA-salt hypertensive rats. 

M.J. Fhaner, G. Swain and J.J. Galligan. Michigan State 

Univ. 

C7 955.7 Role of TLR4 expression in experimental 

hypertension. G.F. Bomfim, R.C. Tostes, Z. Fortes and M.H. 

Carvalho. Univ. of São Paulo. 

C8 955.8 Influence of ACE gene polymorphisms on 

antihypertensive efficacy, left ventricular mass and proteinuria 

in children undergoing ramipril monotherapy. R. Buescher, 

I. Finkelberg and P.F. Hoyer. Univ. of Duisburg-Essen, 

Germany. 

C9 955.9 Differential alteration of sympathetic 

norepinephrine transporter in mesenteric arteries and veins 

in DOCA-salt hypertensive rats. S. Sangsiri, H. Dong, G.M. 

Swain, J.J. Galligan and H. Xu. Michigan State Univ. 

C10 955.10 Beneficial vascular effect of a non-selective 

PPAR activator in aorta of spontaneously hypertensive rats. C. 

Qu, S.W.S. Leung, P.M. Vanhoutte and R.Y.K. Man. Univ. of 

Hong Kong. 

C11 955.11 Mitogen-activated protein kinase phosphatase-1 

is low in dorsal medulla of hypertensive (mRen2)27 

transgenic rats. M. Nautiyal, E.A. Tallant, M.C. Chappell and 

D.I. Diz. Wake Forest Univ. Sch. of Med. 

956. Vascular Endothelial Function: 

General 

Poster 



C12 956.1 Myogenic constriction occurs in the absence 

of a detectable increase in pLC20 in the presence of agonistinduced 

tone. A.F. El-Yazbi, E.J. Walsh, M.P. Walsh and W.C. 

Cole. Univ. of Calgary. 

C13 956.2 Angiotensin (1-7) induced inhibition of the 

nerve-stimulation induced release of norepinephrine and 

neuropeptide Y from the rat mesenteric arterial bed: role of 

prostacyclin. J.M. Murray, H. Macarthur and T.C. Westfall. 

Saint Louis Univ. 

C14 956.3 Regulation of vascular endothelial signaling 

with therapeutic nanoparticles that target the NF-kB pathway. 

H. Pan, G.M. Lanza and S.A. Wickline. Washington Univ. Sch. 

of Med. 

C15 956.4 Loss of endothelial focal adhesion kinase 

in mice causes lung vascular leak, alveolar destruction and 

inflammation. T.L. Thennes, M. Tauseef, N. Knezevic, J.R. 

Göthert, T-L. Shen, J-L. Guan, D.A. Cheresh and D. Mehta. 

Univ. of Illinois at Chicago, Univ. Hosp. of Essen, Germany, 

Natl. Taiwan Univ., Univ. of Michigan and UCSD. 

C16 956.5 Inhibition of TNF-a-induced reactive oxygen 

species generation, cell adhesion molecule expression and 

NF-kB activation by 5-hydroxymethylfurfural in human umbilical 

vein endothelial cells. H.K. Kim, H.J. Kim, J.K. Park, E.N. Lee, 

S-O. Oh, S-Y. Baek, B-S. Kim, Y-W. Choi and S. Yoon. Sch. of 

Med. and Col. of Natural Resources and Life Sci., Pusan Natl. 


290

tuesday 

C17 956.6 High intravascular pressure decreases 

endothelial Ca 2+ pulsars and impairs endothelium-dependent 

vasodilation in mouse mesenteric arteries. S.K. Sonkusare, 

T.J. Heppner, A.D. Bonev, R.M. Hannah, Y. Talline, M.I. 

Kotlikoff and M.T. Nelson. Univ. of Vermont and Cornell Univ. 

C18 956.7 Cyclic AMP response element binding protein, 

Creb, induces endothelial cell proliferation and angiogenesis 

in response to thrombin. K.R. Chava and D. Mehta. Univ. of 

illinois at Chicago. 

C19 956.8 High molecular weight kininogen regulates 

endothelial function. D.S. Kolte, N. Osman, J. Yang and Z. 

Shariat-Madar. Univ. of Mississippi. 

957. Coronary and Cerebral Artery 

Endothelial Function 

Poster 



C20 957.1 Rapid estrogen signaling via GPER in human 

coronary artery smooth muscle. G. Han, H. Ma, S.A. Barman, 

M. Sellers, X. Yu, J.N. Stallone and R.E. White. Texas A&M 

Univ. and Med. Col. of Georgia. 

C21 957.2 Nitric oxide synthase and soluble guanylyl 

cyclase activation are required for hypoxic endotheliumdependent 

contractions of the porcine coronary artery. C.K.Y. 

Chan, J.C.W. Mak, R.Y.K. Man and P.M. Vanhoutte. Univ. of 

Hong Kong. 

C22 957.3 Melatonin inhibits NO-induced cGMP 

accumulation by increasing PDE5 phosphorylation in coronary 

arteries. P. Shukla, A. Grazul-Bilska and S.T. O’Rourke. 


C23 957.4 Coronary endothelium: new pharmacological 

target for heart hypertrophy/failure. X. Sun and D.D. Ku. Univ. 

of Alabama at Birmingham. 

C24 957.5 Adiponectin is secreted by vascular smooth 

muscle cells and regulates muscle contractile phenotype. M. 

Ding, R.J. Wagner and K.A. Martin. Dartmouth Col. and Yale 

Univ. 

C25 957.6 Regulation of cerebral blood flow by hydrogen 

sulfide. G. Ahmed, A.O. Oyekan and M.A. Yakubu. Texas 

Southern Univ. Col. of Pharm. & Hlth. Sci. and Texas Southern 

Univ. 

C26 957.7 Possible involvement of cytoskeletal reorganization 

in PKC-induced cerebroarterial constriction. A.F. El- 

Yazbi. Univ. of Calgary. 

958. Role of Adenosine Receptors in 

Vascular Function 

Poster 



C27 958.1 Role of A 1 

adenosine receptors in vascular 

reactivity and inflammation in a murine model of allergic asthma. 

D.S. Ponnoth, A. Nadeem, S. Tilley and S.J. Mustafa. West 

Virginia Univ. and Univ. of North Carolina at Chapel Hill. 

C28 958.2 Evidence for the role of A 2B 

adenosine receptor 

in the regulation of vascular tone using A 2B 

KO mice. M. Sharifi 

Sanjani, D.S. Ponnoth, K. Roush, S. Tilley and S.J. Mustafa. 

West Virginia Univ. and Univ. of North Carolina at Chapel Hill. 

pHarmacology 

C29 958.3 Exaggerated vasoconstriction depends on 

w-hydroxyylase through adenosine A 1 

receptor in A 1 

WT 

compared to A 1 

KO mouse aorta. S.S. Kunduri, M.A. Nayeem, 

J.R. Falck, J. Schnermann and S.J. Mustafa. West Virginia 

Univ., Univ. of Texas Southwestern Med. Ctr. and NIDDK, NIH. 

C30 958.4 The involvement of PPARa in epoxide-induced 

activation of adenosine receptors in angiogenesis. Y.Q. Rizvi, 

M. Choi, C. Mehta and A.O. Oyekan. Texas Southern Univ. 

959. Role of Nitric Oxide in Vascular 

Function 

Poster 



C31 959.1 Interaction between sympathomimetic amines, 

ephedrine, tyramine and norepinephrine at uptake 1 in 

sympathetic nerves and the role of nitric oxide. J.A. Simaan. 

American Univ. of Beirut. 

C32 959.2 p38 MAPK inhibition prevents angiotensin 

II-induced elevation of arginase activity and impaired 

vasorelaxation. A. Shatanawi, M.J. Romero, S. Chandra, L. 

Yao, H. Flores Toque, J.A. Iddings, R.B. Caldwell and R.W. 

Caldwell. Med. Col. of Georgia. 

C33 959.3 Mechanisms of AVE3085 against asymmetrical 

dimethylarginine-induced endothelial dysfunction. H-M. Xue, 

G-W. He, J-H. Huang and Q. Yang. Chinese Univ. of Hong 

Kong, Nankai Univ & TEDA Cardiovasc Hosp, Tianjin, People’s 

Republic of China and Providence Heart & Vasc. Inst., Oregon 

Univ. & Hlth. Sci. 

C34 959.4 Peroxynitrite and hydrogen peroxide increase 

arginase activity through the RhoA/Rho kinase pathway. S. 

Chandra, M.J. Romero, A. Shatanawi, R.B. Caldwell and 

R.W. Caldwell. Med. Col. of Georgia. 

C35 959.5 Genetic inactivation of endothelial nitric oxide 

synthase enhances vasodilator effect of cilostazol. A.V.R. 

Santhanam, M.G. Hire, L.A. Smith and Z.S. Katusic. Mayo 

Clin. Col. of Med. 

C36 959.6 A novel signaling pathway for high output 

eNOS-derived nitric oxide in inflamed endothelial cells. J.L. 

Lowry, V. Brovkovych, Y. Zhang and R.A. Skidgel. Univ. of 

Illinois at Chicago. 

C37 959.7 Impaired l-arginine recycling induces 

compensatory mechanisms in NO-dependent vessels. R. 

Chennupati, B.J.A. Janssen, W.H. Lamers, J.G.R. De Mey 

and S.E. Koehler. Maastricht Univ., Netherlands. 

C38 959.8 Phosphorylation of endothelial nitric oxide 

synthase is increased in mouse model of GTP-cyclohydrolase 

I deficiency. L.V. d’Uscio and Z.S. Katusic. Mayo Clin. 

C39 959.9 Nitroglycerin reduces TNF-a toxicity to 

endothelial cells but compromises the protective effects of 

propofol. H-m. Liu, S. Lei, T. Luo, Z-y. Xia, Y. Liu, G.P. Leung, 

P.M. Vanhoutte, M.G. Irwin and Z. Xia. Univ. of Hong Kong 

and Renmin Hosp., Wuhan Univ., People’s Republic of China. 

C40 959.10 Modulation of cyclosporine-induced 

hypertension by central endothelial and neuronal nitric oxide 

synthases. M.M. El-Mas, A.G. Omar, M.M. Helmy and M.M. 

Mohy El-Din. Fac. of Pharm., Univ. of Alexandria, Egypt. 

C41 959.11 Pioglitazone ameliorates cyclosporine-induced 

attenuation of carbachol renovascular vasodilations: role of 

PPARg/nitric oxide synthase signaling. M.M. El-Mas, H.M. El- 

Gowelli, E.I. Saad, K.S. Abd-Elrahman and A-G.A. Abdel- 

Galil. Fac. of Pharm., Univ. of Alexandria, Egypt. 

291 

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Pharmacology 

960. Effect of Natural Products on 

Cardiovascular Function 

Poster 



C42 960.1 EGCG reduces Ang II-induced NAD(P)H 

oxidase and NO synthase expression in HUVECs. H.Y. Ahn, 

C.H. Kim and S.T. Davidge. Col. of Med., Chungbuk Univ., 

Republic of Korea and Univ. of Alberta. 

C43 960.2 Contractions of the SHR aorta to high doses of 

epigallocatechin gallate are due to vasoconstrictor prostanoids. 

Z. Li, M.W. Koo, R.Y. Man and P.M. Vanhoutte. Univ. of Hong 

Kong. 

C44 960.3 Inhibition of TNF-a-induced ROS generation, 

VCAM-1 expression and NF-kB activation by chloroform extract 

of aged black garlic in human umbilical vein endothelial cells. 

J.K. Park, H.K. Kim, M.J. Kim, H.J. Kim, E.N. Lee, S-O. Oh, 

S-Y. Baek, B-S. Kim, Y-W. Choi and S. Yoon. Sch. of Med. 

and Col. of Natural Resources and Life Sci., Pusan Natl. Univ., 


C45 960.4 Antihyperglycemic effect of Centratherum 

anthelminticu, Terminalia chebul and Terminalia bellirica 

extracts. A. Arya, B.S. Haerian and M. Ali Mohamad. Univ. of 

Malaya, Malaysia. 

C46 960.5 Immunohistochemical studies of vascular 

endothelial growth factor and tumor suppressor protein p53 in 

mammary tumor of mice under the effect of green tea. A.M.A. 

Amin. Med. Res. Inst., Alexandria, Egypt. 

C47 960.6 Ginger oleoresin supplementation lowers 

blood pressure and triglyceride levels in hypercholesterolemic 

rats. T.R. Henry, O.R. Simon and M. Gossell-Williams. Univ. 

of West Indies, Jamaica. 

961. Cardiovascular Pharmacology 

Poster 



C48 961.1 In utero exposure to nicotine reduces PKC 

epsilon gene expression in the fetal rat heart. J.C.A. Lawrence, 

D. Xiao and L. Zhang. Loma Linda Univ. 

C49 961.2 Acute nicotine attenuates reflex tachycardia 

in male rats via inhibition of baroreceptor-mediated cardiac 

sympathetic control. M.M. El-Mas, S.M. El-gowilly, M.A. Fouda 

and E.I. Saad. Fac. of Pharm., Univ. of Alexandria, Egypt. 

C50 961.3 Estrogen protects female rats against the 

nicotine-induced attenuation of reflex tachycardia: role of central 

estrogen receptors. M.M. El-Mas, S.M. El-gowilly, M.A. Fouda 

and E.I. Saad. Fac. of Pharm., Univ. of Alexandria, Egypt. 

C51 961.4 Metoprolol reduces central sympathetic drive 

and restores cardiac output during the development of ischemic 

heart failure in conscious rats. S.K. Burris and M. Knuepfer. 

Saint Louis Univ. 

C52 961.5 Amelioration by tempol of the hypertensive and 

baroreflex depressant effects of cyclosporine in conscious rats: 

role of cardiac autonomic control. M.M. El-Mas, A.G. Omar, 

M.M. Helmy and M.M. Mohy El-Din. Fac. of Pharm., Univ. of 

Alexandria, Egypt. 


C53 961.6 No distinct address and message domains 

involved in endothelin-1/ ET A 

-mediated arterial contractions. 

M.G. Compeer, M.J.P.M.T. Meens, T.M. Hackeng and J.G.R. 

De Mey. Maastricht Univ., Netherlands. 

C54 961.7 TRP channel activation promotes dissociation 

of ET-1/ET A 

-complexes and terminates vasoconstriction in rat 

resistance arteries. M.J.P.M.T. Meens, M.G. Compeer, M.A. 

van Zandvoort, T.M. Hackeng and J.G.R. De Mey. Maastricht 

Univ., Netherlands. 

C55 961.8 Knockout strategy reveals synergy between 

alpha-1-adrenoceptor subtypes and P2X receptors in nerveinduced 

vascular responses. J.C. McGrath, P.C. Simpson, 

C.J. Daly and L. Methven. Univ. of Glasgow and UCSF. 

C56 961.9 Inhibition of reverse-mode sodium-calcium 

exchange by the anti-anginal agent ranolazine. D. Soliman, L. 

Wang, K.S.C. Hamming, L.C. Matemisz, A.S. Clanachan and 

P.E. Light. Univ. of Alberta. 

C57 961.10 Adenosinergic modulation of the imidazoline 

I1-receptor-dependent hypotensive effect of ethanol in acute 

renal failure. M.M. El-Mas, H.M. El-Gowelli, O.F. Harraz, 

A-R.M. Ghazal and M.M. Mohy El-Din. Fac. of Pharm., Univ. 

of Alexandria, Egypt. 

C58 961.11 Aldehyde dehydrogenase 1 in the metabolism 

and bioactivation of organic nitrates. N.A. Page, P-S. Tsou, 

S.M. Fung and H-L. Fung. Univ. at Buffalo. 

C59 961.12 Activation of aldehyde dehydrogenase 2 

reduces nitroglycerin-induced cardiac damage. L. Sun and D. 

Mochly-Rosen. Stanford Univ. 

C60 961.13 Improved antioxidant and lipid profiles underlie 

the protective effect of pioglitazone against cyclosporineinduced 

endothelium dysfunction in isolated rat aortas. M.M. 

El-Mas, H.M. El-Gowelli, E.I. Saad, K.S. Abd-Elrahman 

and A-G.A. Abdel-Galil. Fac. of Pharm., Univ. of Alexandria, 

Egypt. 

C61 961.14 Norepinephrine decreases ejection fraction and 

downregulates sepsis-induced elevated antiapoptotic genes in 

a hyperdynamic polymicrobial septic rat model. M. Chopra, P. 

Das, H.B. Golden, D.E. Dostal and A.C. Sharma. Amity Univ., 

India and Texas A&M Hlth. Sci. Ctr., Dallas and Temple. 

C62 961.15 Modulation of myocardial mitochondrial VDAC/ 

mitoK ATP 

channels in sepsis. A.C. Sharma, P. Das and M. 

Chopra. Texas A& M Hlth. Sci. Ctr. Baylor Col. of Dent. and 

Amity Univ., India. 

C63 961.16 Antiarrhythmic drug-induced modulation of Kv 

channel surface density in cardiomyocytes. S.M. Schumacher, 

L. Zhang and J.R. Martens. Univ. of Michigan. 

962. Signal Transduction: Second 

Messengers 

Poster 



C64 962.1 Effect of alcohols on a soluble form of adenylyl 

cyclase type 7 expressed in bacteria. U. Dokphrom and M. 

Yoshimura. Sch. of Vet. Med., LSU. 

C65 962.2 Hydrogen sulfide stimulates cyclic AMP 

formation in mammalian retina through the adenylyl cyclase 

pathway. Y.F. Njie-Mbye, M. Kulkarni, C.A. Opere and S.E. 

Ohia. Texas Southern Univ. and Creighton Univ. 

292

tuesday 

C66 962.3 Hydrogen peroxide enhances the expression of 

Gi protein in aortic vascular smooth muscle cells : relationship 

with adenylyl cyclase. N. Mbong and M.B. Anand-Srivastava. 

Univ. of Montreal. 

C67 962.4 A dominant negative allele of Gs alpha blocks 

signaling through adenylyl cyclase. R.P. Rylaarsdam, D. 

Sultan, A. Ghouse and P. Patel. Benedictine Univ., IL. 

C68 962.5 Heterologous sensitization of human AC5: 

dependence on heterotrimeric G proteins. K.F.K. Ejendal, R. 

Sadana, P-A. Vidi, C.W. Dessauer and V.J. Watts. Purdue 

Univ. and Univ. of Texas Hlth. Sci. Ctr. at Houston. 

C69 962.6 Angiotensin II-induced reactive oxygen radical 

production by NAD(P)H oxidase is mediated by arachidnic 

acid metabolism via cytochrome P4501B1 in vascular smooth 

muscle cells. C.Y. Song, H.U.B. Ghafoor, F.A. Yaghini, X.R. 

Fang and K.U. Malik. Univ. of Tennessee Hlth. Sci. Ctr., 

Memphis. 

C70 962.7 Atrial natriuretic peptide activates pancreatic 

islet phosphatidylinositol-3′-kinase/Akt/FoxO1a/cyclin D2 

signaling. H. You and S.G. Laychock. Univ. at Buffalo, SUNY. 

C71 962.8 Inhibition of fMLP-stimulated respiratory 

burst in human neutrophils by 5-hydroxy-2-(4-hydroxy-3- 

methoxyphenyl)-3,7-dimethoxy-4H-chromen-4-one (MSF-2), 

a natural lignan extract from Melicope semecarpifolia: specific 

inhibition of phosphatidylinosit C-H. Liao, C-H. Liu, J-J. Chen, 

C-P. Tseng and Y-J. Day. Col. of Med., Chang-Gung Univ., 

Grad. Inst. of Natural Products, Taoyuan, Ta-jen Univ., Grad. 

Inst. of Med. Biotechnol., Taoyuan and Chang-Gung Memory 

Hosp., Taiwan. 

C72 962.9 Cytoplasmic RIP140 negatively modulates 

adiponectin secretion in adipocytes. Y-S. Chuang, P-C. Ho, 

S.D. Persuad, Y-W. Lin, S.C. Chan, S-C. Luo and L-N. Wei. 

Univ. of Minnesota, Minneapolis. 

C73 962.10 A negative regulatory pathway of GLUT4 

trafficking in adipocyte: new function of RIP140 in the cytoplasm 

via AS160. P-C. Ho, Y-W. Lin, Y-C. Tsui, P. Gupta and L-N. 

Wei. Univ. of Minnesota, Minneapolis. 

C74 962.11 Activation of P2X7 receptor can lead to NAD + 

release from astrocytes. W. Ying, W. Xia and H. Chen. Rui Jin 

Hosp. and Shanghai Jiao Tong Univ. Sch. of Med. 

C75 962.12 SH3 domain of bPix interacts with Sprouty2. C. 

Ying, K.M. Anderson and T.B. Patel. Loyola Univ. Chicago, 

Stritch Sch. of Med. 

C76 962.13 Orphanin FQ/nociceptin activates nuclear 

factor kappa B in neuronal cells. C.L. Donica, H.O. Awwad, H. 

Wu and K.M. Standifer. Univ. of Oklahoma Hlth. Sci. Ctr. 

963. Signal Transduction: MAP Kinases 

Poster 



C77 963.1 Lipopolysaccharide-induced expression of 

VCAM-1 in human renal mesangial cells. J-T. Chen and C-M. 

Yang. Chang Gung Univ., Taiwan. 

C78 963.2 Modulation of epidermal growth factor 

stimulated ERK phosphorylation and cell motility by inositol 

trisphosphate kinase. M.C. Sekar, K. Shahiwala, L. Leloup 

and A. Wells. Univ. of Findlay and Univ. of Pittsburgh. 

pHarmacology 

C79 963.3 TNF-a induces cytosolic phospholipase A 2 

expression via MAPKs and NF-kB in human pulmonary alveolar 

epithelial cells. Y-C. Hsiao and C-M. Yang. Chang Gung Univ., 

Taiwan. 

C80 963.4 EV71 induces COX-2 expression and PGE 2 

synthesis through c-Src/EGFR/p42/p44 MAPK/CREB in SK- 

N-SH cells. W-H. Tung and C-M. Yang. Chang Gung Univ., 

Taiwan. 

C81 963.5 Endothelin-1-induced COX-2 expression in 

mouse brain endothelial cells. H-J. Chan and C-M. Yang. 

Chang Gung Univ., Taiwan. 

C82 963.6 The SWIM domain of MEKK1 is required for 

complex formation with Jun that controls Fra-2 ubiquitination. 

B.D. Cuevas and T. Duellman. Loyola Univ. Med. Ctr. 

C83 963.7 Mnk1 is essential to efficient murine T cell IFNg 

release. B.L. Burnette and J.B. Monahan. Pfizer Global R&D, 

Chesterfield, MO. 

964. Chemotherapy 

Poster 



C84 964.1 Pharmacological and toxicological study of 

two analogues of amphotericin by using in vitro models. A. 

León-Buitimea, R. Morales-Nava, M. Fernández-Zertuche, 

I. Ortega-Blake, J. Reyes-Esparza and L. Rodriguez- 

Fragoso. Autonomous Univ. del Estado de Morelos, Mexico 

and Autonomous Univ. of Mexico, Cuernavaca. 

C85 964.2 Danazol in the treatment of thrombocytopenia 

associated with the use of peg-interferon alfa 2a and ribavirin 

in patients with chronic hepatitis C. D. Gómez-Galicia, G. 

Cabrera-Alvarez, L. Rodriguez-Fragoso and J. Reyes- 

Esparza. Univ. Autónoma del Estado de Morelos and HGZ 1 

IMSS, Cuernavaca. 

C86 964.3 Preparation of a claudin-4-targeted anti-tumor 

molecule. M. Kondoh, R. Saeki, H. Kakutani, T. Hamakubo, 

A. Watari and K. Yagi. Grad. Sch. of Pharmaceut. Sci., Osaka 

Univ. and Univ. of Tokyo. 

C87 964.4 Superior antiproliferative activity of histone 

deacetylase inhibitor apicidin and proteasome inhibitors against 

human colorectal cancer cells. M.S. Abaza, A-M. Bahman and 

R. Al-Attiyah. Kuwait Univ. 

C88 964.5 CAMP-dependent pathway(s) directs the B-Raf 

MAPK-mediated cytosolic mislocalization of p27kip-cyclin D1 

in renal cancer. K.Y. Tham, J.D. Cohen, T.J. Monks and S.S. 

Lau. Univ. of Arizona. 

C89 964.6 SRJ23, a new investigational anti-prostate 

cancer agent. H.C. Wong, S.R. Sagineedu, N.H. Lajis and J. 

Stanslas. Univ. Putra Malaysia. 

C90 964.7 Histone acetylation upregulates phosphatidylinositol-3,4,5-triphosphate-dependent 

Rac exchange factor 

1 expression to promote prostate cancer metastasis. C-Y.A. 

Wong, D. Ha, Y. Xie, D.W. Wolff, P.W. Abel and Y. Tu. Creighton 


C91 964.8 Low dose deguelin suppresses in situ oral 

cancer metastasis through downregulation of Akt-independent 

NF-kB signaling. Y-H. Jan, T-C. Lai, T. Chiu, J-S. Chang and 

M. Hsiao. Genomics, Res. Ctr., Acad. Sinica, Taipei. 

t 

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293

Pharmacology 

C92 964.9 Effect of resveratrol and curcumin on tumor 

volume and survival in Ehrlich ascites carcinoma-bearing mice. 

M.F. El-Azab, H. Hishe, Y. Moustafa and E-S. El-Awady. Suez 

Canal Univ. 

C93 964.10 Resveratrol enhances the sensitivity of 

doxorubicin-mediated cell proliferation, invasion, and migration 

in human breast cancer cell lines. H.S. Kim and T.H. Kim. Col. 

of Pharm., Pusan Natl. Univ., Republic of Korea. 

C94 964.11 Identification of novel chemosensitivity nodes 

using siRNA synthetic lethal screens. C.A. Kitchens, P.R. 

McDonald, N.G. Thaker, T.Y. Shun, I.F. Pollack and J.S. Lazo. 

Univ. of Pittsburgh. 

C95 964.12 Novel protein kinase D inhibitors cause potent 

arrest in cancer cell growth and motility. C.R. LaValle, K. Bravo- 

Altamirano, K. Giridhar, J. Chen, E.R. Sharlow, J.S. Lazo, P. 

Wipf and Q.J. Wang. Univ. of Pittsburgh. 

C96 964.13 Mechanistic exposure-response model of 

combination rituximab chemotherapy in murine lymphoma 

xenografts. D.E. Mager and J.M. Harrold. Univ. at Buffalo, 

SUNY. 

C97 964.14 Regulation of breast cancer resistance protein 

(BCRP/ABCG2) by microRNA-328. Y. Pan, M. Morris and A. 

Yu. Univ. at Buffalo, SUNY. 

C98 964.15 Efficacy versus toxicity of docetaxel in Asian 

and Caucasian cancer patients from the pharmacogenomics 

perspectives: a review of the literature. R.S. Jabir, R. Naidu, 

M. Azrif and J. Stanslas. Univ. Putra Malaysia, Sch. of Med., 

Monash Univ. Malaysia Campus and Univ. Kebangsaan 

Malaysia Med. Ctr. 

C99 964.16 Gbg signaling promotes breast cancer cell 

migration and invasion. J.K. Kirui, Y. Xie, D.W. Wolff, H. Jiang, 

P.W. Abel and Y. Tu. Creighton Univ. Sch. of Med. 

C100 964.17 Upregulated phosphoinositide 3-kinase g 

promotes breast cancer metastasis. Y. Xie, J.K. Kirui, H. Jiang, 

C. Deng and Y. Tu. Creighton Univ. Sch. of Med. 

965. Mechanisms of Cell Injury and Death 

Poster 



C101 965.1 Inhibition of NRF2 in cancer cells enhances 

apoptotic response and suppresses cell growth:a potential 

involvement of the p53 signaling. T-h. Kim, A. You, S. 

Manandhar, C-w. Nam and S-J. Kang. Col. of Pharm., 

Yeungnam Univ., Republic of Korea. 

C102 965.2 Targeting phosphodiesterase 7B and exchange 

protein directly activated by cAMP-1 in chronic lymphocytic 

leukemia. F. Murray, E. Apaydin, L. Zhang, A. Zahno, L. 

Rassenti, T.J. Kipps and P.A. Insel. UCSD. 

C103 965.3 Cytotoxic activity of Taraxacum officinale in 

OV2008 human ovarian cancer cell line is mediated by caspase 

8 activity. A.S-A. Levy and D.G. Stupack. Univ. of West Indies, 

Jamaica and UCSD. 

C104 965.4 The molecular mechanism of xanthohumolinduced 

apoptosis in MCF-7 and MCF-7/ADR cells. Y. Kang, 

M-A. Park, K.W. Kang and J-A. Kim. Yeungnam Univ. Col. of 

Pharm. and Chosun Univ. Col. of Pharm., Republic of Korea. 

C105 965.5 NADH can induce necrosis of C6 glioma 

cells and Neuro2a cells. Y. Ma, C. Zhao, W. Xia and W. Ying. 

Shanghai Jiao Tong Univ., People’s Republic of China. 


C106 965.6 NAD + treatment can block rotenone-induced 

nuclear apoptotic changes of PC12 cells. Y. Hong, J. Shao, W. 

Xia and W. Ying. Rui Jin Hosp. and Shanghai Jiao Tong Univ. 

Sch. of Med. 

C107 965.7 Radiosensitizing effects of xanthohumol on 

human cancer cells. S-W. Heo, Y. Kang, M-A. Park, K.W. Kang 

and J-A. Kim. Yeungnam Univ. Col. of Pharm. and Chosun 

Univ. Col. of Pharm., Republic of Korea. 

C108 965.8 Involvement of NSAID-activated gene-1 in 

a novel synthetic hexahydrocannabinol analogue-induced 

growth inhibition and apoptosis of colon cancer cells. D. Thapa, 

D. Babu, M-K. Kwak, Y-R. Lee and J-A. Kim. Yeungnam Univ. 

Col. of Pharm. and Sch. of Chem. Engin. and Technol., Republic 

of Korea. 

C109 965.9 The mechanisms by which fenretinide and alltrans 

RA induces apoptosis and differentiation, respectively in 

human HCC cells. N. Bushue and Y-J.Y. Wan. Univ. of Kansas 

Med. Ctr. 

C110 965.10 Butyrate uptake and effect on proliferation, 

differentiation, viability and apoptosis of Caco-2 cells: influence 

of polyphenols. P. Gonçalves, J.R. Araújo and F. Martel. Fac. 

of Med., Univ. of Porto, Portugal. 

C111 965.11 Effect of porcine-serum on viability, proliferation 

and morphology of hepatic cells. U. Osuna-Martínez, A. 

Gómez-Solís, E. Alvarez-Ayala, J. Reyes-Esparza and L. 

Rodriguez-Fragoso. Univ. Autónoma del Estado de Morelos, 

Mexico. 

966. Immunopharmacology 

Poster 



C112 966.1 Marine sponge Hymeniacidon sp. amphilectane 

metabolites potently inhibit rat brain microglia thromboxane B 2 

generation. A.M. Mayer, S. Chaudhry, M.L. Hall, E. Aviles 

and A.D. Rodriguez. Midwestern Univ., IL and Univ. of Puerto 

Rico. 

C113 966.2 Phagocyte immunomodulatory activity of 

oenothein B, a macrocyclic elligatannin isolated from Epilobium 

angustifolium. I.A. Schepetkin, L.N. Kirpotina, L. Jakiw, C.L. 

Blaskovich, M.A. Jutila and M.T. Quinn. Montana State 

Univ. 

C114 966.3 Human mast cell degranulation is distinguished 

from selective secretion of TNF through intracellular calcium, 

energy and mitochondrial morphology dynamics. B. Zhang, A. 

Angelidou, K-D. Alysandratos, M. Tagen, D. Kempuraj, S. 

Asadi and T. Theoharides. Tufts Univ. 

C115 966.4 Novel small-molecule agonists of human 

formyl peptide receptors and pharmacophore models of their 

recognition. L.N. Kirpotina, A.I. Khlebnikov, I.A. Schepetkin, 

R.D. Ye, M-J. Rabiet, M.A. Jutila and M.T. Quinn. Montana 

State Univ., Altai State Tech Univ., Russia, Univ. of Illinois, 

Chicago and CEA, Grenoble. 

C116 966.5 Novel role of STAT1 in the recovery from 

doxorubicin-induced immunosuppression. N. Parajuli, S. 

Datta, S. Pohle, A. Villunger, J.B. Koller, L. Hannesdóttir, 

V. Labi and W. Doppler. Univ. of Arkansas for Med. Sci. and 

Innsbruck Med. Univ. 

294

tuesday 

C117 966.6 Ramaline inhibits LPS-induced NO release in 

macrophages by regulating MAPK and NF-kB activities. H-J. 

Park, J.H. Yim and S. Pyo. Col. of Pharm., Sungkyunkwan 

Univ., Republic of Korea and Korea Polar Res. Inst., Incheon. 

C118 966.7 Histone deacetylases play a critical role in 

regulating IFNa-mediated anti-HCV gene expression. S. 

Mathews, F. Ademosu, S. Joshi-Barve, C. McClain and S. 

Barve. Univ. of Louisville and Louisville VA Med. Ctr. 

C119 966.8 An optimized method for paroxysmal nocturnal 

hemoglobinuria screening flow cytometric diagnosis. A.M. 

Peiro, N. Bastande, M.L. Fernández, J. Lucas, E. López- 

Abadía and F. Tarín. Gen. Hosp. of Alicante, Spain. 

C120 966.9 Ethanol inhibits lipid raft-dependent TCR 

signaling and IL-2 expression: potential mechanism of alcoholinduced 

immune suppression. S. Joshi-Barve, S. Ghare, M. 

Patil, P. Hote, J. Suttles, C. McClain and S. Barve. Univ. of 

Louisville and Louisville VA Med. Ctr. 

C121 966.10 Metabolism of prostaglandin glyceryl esters by 

human carboxylesterases, CES1 and CES2, and its inhibition 

by bioactive metabolites of organophosphate insecticides. M.K. 

Ross, A. Borazjani, P.M. Potter and S. Xie. Col. of Vet. Med., 

Mississippi State Univ. and St. Jude Children’s Hosp. 

C122 966.11 Pharmacological evaluation of FL-6, a new 

immunomodulatory drug, on coccidiosis in chickens. M. 

Corbalá-Nava, G. Tellez, B. Hargis, L. Rodríguez-Fragoso 

and J. Reyes-Esparza. Autonomous Univ. del Estado de 

Morelos, Mexico and Univ. of Arkansas. 

967. Drug Metabolism: Phase I and Phase II 

Enzymes 

Poster 



C123 967.1 Tecarfarin: a new oral anticoagulant and 

the characterization of its in vitro metabolism using rat, dog, 

and human hepatocytes. L. Lightning, P. Kumaraswamy, 

R. Coleman, I. Irwin, M. Palme and P. Druzgala. ARYx 

Therapeut., Fremont, CA. 

C124 967.2 NMR-based structural model of rabbit 

cytochrome P450 2B4 with the analgesic amidopyrine, 

the intermediate desmethylamidopyrine, and its product 

aminoantipyrine: implications for the structural basis of 

sequential metabolism. A.G. Roberts, K. Vu and J.R. Halpert. 

UCSD Skaggs Sch. of Pharm. and Pharmaceut. Sci. and 

Sahlgrenska Acad., Univ. of Gothenburg, Sweden. 

C125 967.3 Suppression of cytochrome P450 reductase 

expression in hepatoma cells replicates the hepatic lipidosis 

observed in hepatic reductase-null mice. T.D. Porter, S. 

Banerjee and E.I. Stolarczyk. Univ. of Kentucky. 

C126 967.4 Determination of mouse liver and lung Fmo 

isoforms by absolute quantification. D.E. Williams, M.C. 

Henderson, J.T. Morre and S.K. Krueger. Oregon State 

Univ. 

C127 967.5 Lack of substrate inhibition in a monomeric 

form of human cytosolic SULT2A1. I.T. Cook, T. Leyh and C. 

Falany. Univ. of Alabama at Birmingham and Albert Einstein 

Col. of Med. 

C128 967.6 Residence of p450 system enzymes in 

endoplasmic reticular lipid microdomains. L. Brignac-Huber, 

R. Reed and W.L. Backes. LSU Hlth. Sci. Ctr., Metairie and 

New Orleans. 

pHarmacology 

C129 967.7 Studies on the subcellular location and 

molecular mobility of human cytosolic sulfotransferase 

SULT1C1 in living human embryonic kidney 293 cells. J. 

Sheng. Massachusetts Col. of Pharm. and Hlth. Sci. 

C130 967.8 Homology modeling and molecular dynamics 

of CYP1A1 and CYP2B1 to explore aryl derivatives metabolism 

by docking, followed by experimental assays. J.E. Mendieta- 

Wejebe, J. Correa-Basurto, J.G. Trujillo-Ferrara and M.C. 

Rosales-Hernández. Grad. Sch. of Med.-IPN, Mexico City. 

C131 967.9 HPLC-UV analysis of bupropion and 

hydroxybupropion: application to in vivo pharmacokinetic 

drug-drug interaction studies between bupropion and potent 

CYP2B6 inhibitors. A.L. Myers, J.C. Molnari, B.M. Moeller 

and A.L. Myers. Drake Univ. 

C132 967.10 Tecarfarin: a novel oral anticoagulant and 

characterization of its pharmacokinetics, tissue distribution, 

and mass balance in Sprague-Dawley rats. S. Rao, L. Shao, 

I. Irwin, M. Palme and P. Druzgala. ARYx Therapeut. Inc., 

Fremont, CA. 

C133 967.11 The effect of obesity on drug metabolism in 

African-American children. M. Chiney and L.A.L. Johnson. Col. 

of Pharm. and Sch. of Med., Univ. of Minnesota, Minneapolis. 

C134 967.12 Human UDP-glucuronosyltransferases are 

involved in the metabolism of the natural resveratrol analogues 

arachidin-1, arachidin-3 and piceatannol. A. Radominska- 

Pandya, V. Nair, S.M. Bratton, A.E. Gallus-Zawada, P.L. 

Prather and F. Medina-Bolivar. Univ. of Arkansas for Med. Sci. 

and Arkansas State Univ. 

C135 967.13 Ligand-induced conformational changes 

in cytochrome P450 2B4: a multi-technique approach. P.R. 

Wilderman, S.C. Gay, A.G. Roberts, S. Li, T. Liu, V.L. Woods 

and J.R. Halpert. Scaggs Sch. of Pharm. and Pharmaceut. 

Sci. and Dept. of Med., UCSD. 

C136 967.14 Structural importance of residue 334 in the 

stability of cytochromes P450 2B6 and 2B11. J.C. Talakad, 

P.R. Wilderman, D.R. Davydov, S. Kumar and J.R. Halpert. 

Skaggs Sch. of Pharm. and Pharmaceut. Sci., UCSD and Univ. 

of Missouri-Kansas City. 

C137 967.15 Determinants of variability in divalproex 

sodium (VPA) glucuronidation in children. J.S. Leeder, R.E. 

Pearce, K.E. Price, R.M. Ward, J.F. Bale, F.S. Abbott, T.K.H. 

Chang, M.J. Kennedy, J. Sullivan and A. Gaedigk. Children’s 

Mercy Hosps. and Clins., Kansas City, MO, Univ. of Utah, Univ. 

of British Columbia, Sch. of Pharm., Virginia Commonwealth 

Univ. and Kosair Children’s Hosp., Louisville. 

C138 967.16 Crystal structure of a cytochrome P450 2B6 

genetic variant in complex with the inhibitor 4-(4-chlorophenyl) 

imidazole at 2.0 Å resolution. S.C. Gay, M.B. Shah, J.C. 

Talakad, K. Maekawa, A.G. Roberts, P.R. Wilderman, L. 

Sun, J.Y. Yang, S.C. Huelga, Q. Zhang, C.D. Stout and J.R. 

Halpert. UCSD, Univ. of Texas Med. Branch and The Scripps 

Res. Inst. 

C139 967.17 Mitochondrion is a novel site of biotransformation 

of dichloroacetate by glutathione transferase zeta. W. 

Li, M.O. James, S. McKenzie and P.W. Stacpoole. Univ. of 

Florida. 

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Pharmacology 

968. Renal Pharmacology and Toxicology 

Poster 



C140 968.1 Differential effects of angiotensin II on intrarenal 

hemodynamics in rats. I. Igbe and A. Oyekan. Col. of 

Pharm. and Hlth. Sci., Texas Southern Univ. 

C141 968.2 Delayed treatment with actinonin, a meprin A 

inhibitor, protects the renal microcirculation and renal function 

during sepsis in mice. Z. Wang, C. Herzog, G.P. Kaushal and 

P.R. Mayeux. Univ. of Arkansas for Med. Sci. 

C142 968.3 Reactive nitrogen species generation in a 

new in vitro model of sepsis-induced renal epithelial injury. E. 

Pathak and P.R. Mayeux. Univ. of Arkansas for Med. Sci. 

C143 968.4 Role of NRF2 in cyclosporine A-induced renal 

fibrosis. K-A. Jung, D-h. Shin, S. Lee, T.W. Kensler and M-K. 

Kwak. Yeungnam Univ. Col. of Pharm., Republic of Korea and 

Johns Hopkins Univ. Bloomberg Sch. of Publ. Hlth. 

C144 968.5 Comparative protective effect of N-acetyl 

cysteine and tetramethylpyrazine in rats with gentamicin 

nephrotoxicity. B.H. Ali, S. Al Salam, I. Alhusseni and A. 

Nemmar. Sultan Qaboos Univ., Oman and United Arab 

Emirates Univ. 

C145 968.6 3,4-Dichloronitrobenzene and 1,2,3-trichloro-5- 

nitrobenzene in vitro nephrotoxicity in isolated rat renal cortical 

cells. G.O. Rankin, B. Greene, C. Schuetz and D. Anestis. 

Marshall Univ. 

C146 968.7 Mitochondria-targeted antioxidant peptide 

promotes ATP recovery and reduces renal ischemia-reperfusion 

injury. F-Y. Cheng, S. Liu, S. Darrah, Z. Zhao, Y. Soong, D. Wu 

and H.H. Szeto. Weill Cornell Grad. Sch. of Med. Sci. 

969. Gastrointestinal Pharmacology 

Poster 



C147 969.1 Effects of Portulaca polysaccharide on the 

dysbacteria in intestinal tract of mice. J. Yang, X. Hu, X. Meng 

and Y-M. Kang. Jiamusi Univ. and Shanxi Med. Univ., People’s 

Republic of China and LSU. 

C148 969.2 Rifaximin protection of DSS-induced 

inflammatory bowel disease by inhibition of nuclear factor 

kappa B through activation of human pregnane X receptor. 

J. Cheng, Y.M. Shah, X. Ma, X. Pang, K.W. Krausz and F.J. 

Gonzalez. NCI, NIH, Univ. of Michigan Sch. of Med. and Univ. 

of Kansas Med. Ctr. 

C149 969.3 Synthesis, characterization and evaluation of 

derivates of 5-aminosalicylic acid with antioxidant activity in 

inflammatory bowel disease. L.A.R. Duran, J.G.T. Ferrara, 

M.C. Rosales-Hernández, D. Ramírez Rosales and J. Correa 

Basurto. Grad. Sch. of Med.-IPN and Grad. Sch. of Physics 

and Math.-IPN, Mexico City. 

C150 969.4 Administration of ampicillin elevates hepatic 

primary bile acid synthesis through suppression of ileal FGF15 

expression. M. Miyata, Y. Takamatsu, H. Kuribayashi and 

Y. Yamazoe. Grad. Sch. of Pharmaceut. Sci., Tohoku Univ., 


Japan. 

C151 969.5 Electrophysiological characterization of 

postnatal enteric neuron cell line. E.G. Hawkins, W.L. Dewey, 

S. Srinivasan and H.I. Akbarali. Virginia Commonwealth Univ. 

and Emory Univ. 

C152 969.6 Administration of ampicillin increases ileal 

Asbt protein amounts resulting in reduction of fecal bile acid 

excretion in mice. Y. Yamazoe, Y. Takamatsu, M. Hamatsu 

and M. Miyata. Grad. Sch. of Pharmaceut. Sci., Tohoku Univ., 

Japan. 

C153 969.7 Octreotide ameliorates gastric lesions 

in chronically mild stressed rats: possible involvement of 

antioxidant, anti-inflammatory and antiapoptotic mediators. 

N.N. Nassar, D.M. Abdallah, H.F. Zaki and M.F. Schlaan. 

Fac. of Pharm., Cairo Univ. and Fac. of Pharm., Misr Intl. Univ., 

Egypt. 

C154 969.8 Propenone derivatives inhibit TNF-a- and 

TNBS-induced intestinal inflammation in vitro and in vivo. S-Y. 

Park, D. Thapa, Y. Kang, M-A. Park, M-Y. Cho, J-S. Lee, S-W. 

Heo, E-S. Lee and J-A. Kim. Yeungnam Univ. Col. of Pharm., 


C155 969.9 Protective effects of puerarin on liver injury 

induced by d-galactosamine in rats. S.J. Kim, Y.I. Nam, C.W. 

Ahn and Y.C. Kim. Col. of Pharm., Seoul Natl. Univ. 

C156 969.10 Pranlukast prevents cysteinyl leukotrieneinduced 

emesis in the least shrew (Cryptotis parva). S. 

Chebolu, Y. Wang, A. Ray and N.A. Darmani. Western Univ. 

of Hlth. Sci. 

970. Pulmonary Pharmacology and 

Pathology 

Poster 



C157 970.1 Antihistaminergic effect of a pure compound 

(GT) isolated from garden slug (Diplosolenodes occidentalis) 

on tracheal smooth muscle contraction. A.S. Jacob, O.R. 

Simon, D.S. Wheatle and P.L. Ruddock. Univ. of West Indies, 

Jamaica. 

C158 970.2 Epac as a novel relaxant factor in airway 

smooth muscle. M. Schmidt, S. Roscioni, H. Maarsingh, H. 

Meurs and A. Halayko. Univ. of Groningen, Netherlands and 

Univ. of Manitoba. 

C159 970.3 PAR-2 involvement in activation of human 

airway epithelial cells. R. Campbell, S. Boitano and M. 

Halonen. Univ. of Arizona Hlth. Sci. Ctr. 

C160 970.4 Lung apoptotic signalling and oxidative stress 

during sub-chronic administration of doxorubicin to Wistar rats. 

N.G. Machado and P.J. Oliveira. Univ. of Coimbra, Portugal. 

C161 970.5 Long-term effects of gamma-tocopherol 

nebulization in cutaneous burn and smoke inhalation with 

early excision and skin autografting in sheep. Y. Yamamoto, P. 

Enkhbaatar, E.R. Kraft, S. Rehberg, L.E. Sousse, L.D. Traber 

and D.L. Traber. Univ. of Texas Med. Branch. 

C162 970.6 Potentially useful interactions between 

theophylline and salbutamol on cytokine release in human 

monocytes. C. Ezeamuzie and P. Shihab. Fac. of Med., Kuwait 

Univ. 

296

tuesday 

C163 970.7 Liposomal amikacin (Arikace TM ) in the treatment 

of lower respiratory tract Escherichia coli in a patient with cystic 

fibrosis. J. Laskoski and C. Landon. ‘Landon Pediat. Fndn., 

Ventura, CA. 

C164 970.8 Separation, characterization, and proteomic 

analysis of hog-barn dust fractions to identify lung diseaserelevant 

mediators. P.R. Dodmane, P.S. Ciborowski, N.A. 

Schulte, A.J. Heires, D.J. Romberger and M.L. Toews. Univ. 

of Nebraska Med. Ctr. and Omaha VA Med. Ctr. 

C165 970.9 Hog manure extract and porcine pancreatic 

elastase modulate airway epithelial cell EGF receptors, 

calcium signaling, and cytokine release. A.C. Zimbelman, P.R. 

Dodmane, N.A. Schulte, A.J. Heires, D.J. Romberger and 

M.L. Toews. Univ. of Nebraska Med. Ctr. and Omaha VA Med. 

Ctr. 

971. Ocular Pharmacology 

Poster 

pHarmacology /physiology 



C166 971.1 Lacritin, a novel tear glycoprotein, is an effective 

topical treatment in dry eye animal models. A. Hosseini, S.S. 

Samudre, J.D. Sheppard, Jr., R.L. McKown, G.W. Laurie, 

F.A. Lattanzio, Jr. and P.B. Williams. Eastern Virginia Med. 

Sch., James Madison Univ. and Univ. of Virginia. 

C167 971.2 Peroxide-induced production of metabolites 

of polyunsaturated fatty acids in bovine retina, in vitro. C.A. 

Opere, J. Jamil, A. Wright, Y.F. Njie and S.E. Ohia. Creighton 

Univ. and Texas Southern Univ. Sch. of Pharm. 

Physiology 

972. Lymphatic and Venular Function 

Poster 

(Sponsored by: The Microcirculatory Society) 



D1 972.1 Lymph flow in instrumented dogs varies with 

exercise intensity. P.V. Desai, A.G. Williams, Jr., P.R. Prajapati 

and H.F. Downey. Univ. of North Texas Hlth. Sci. Ctr. 

D2 972.2 Lymphatic pump treatment increases thoracic 

duct lymph flow in conscious dogs with edema due to 

constriction of the inferior vena cava. P.R. Prajapati, P.V. Shah, 

H.H. King, A.G. Williams, Jr., P.V. Desai and H.F. Downey. 


D3 972.3 Flow-mediated NO production in the 

endothelium is dependent on eNOS activity and shear. H.G. 

Bohlen, E. Rahbar, J. Moore, W. Wang, A.A. Gashev and D. 

Zawieja. Indiana Univ. Med. Sch. and Texas A&M Univ. 

D4 972.4 Aging of the mesenteric lymph pump. T. Nagai, 

E. Bridenbaugh and A.A. Gashev. Texas A&M Hlth. Sci. Ctr. 

Col. of Med. 

D5 972.5 Collecting lymphatic vessel permeability 

response to atrial natriuretic peptide. J.P. Scallan and V.H. 

Huxley. Univ. of Missouri Med. Sch. 

D6 972.6 Evaluation of gravimetric techniques to estimate 

the microvascular filtration coefficient. R. Dongaonkar, C.M. 

Quick, R.H. Stewart and G.A. Laine. Texas A&M Univ. 

D7 972.7 Simple passive device to ensure isotonic 

contraction of intact tubular or spherical organs. T.L. Nguyen, 

R.H. Stewart, G.A. Laine and C.M. Quick. Texas A&M Univ. 

D8 972.8 Lymphatic pump manipulation mobilizes 

inflammatory mediators into lymphatic circulation. L.M. Hodge, 

J. Huff, A. Schander, A. Williams and F. Downey. Univ. of 

North Texas Hlth. Sci. Ctr. 

D9 972.9 Mechanical and contractile characteristics of 

rat thoracic duct and cervical lymphatics. Z.V. Nepiyushchikh, 

D.C. Zawieja and M. Muthuchamy. Texas A&M Hlth. Sci. Ctr. 

Col. of Med. 

973. Microvascular Flow Regulation/ 

Oxygen Delivery/Networks 

Poster 




D10 973.1 Effects of environmental temperature and light 

intensity on blood physiological parameters of broilers. H.A. 

Olanrewaju, S.L. Branton, J.L. Purswell, S.D. Collier and 

W.A. Dozier III. USDA, Mississippi State. 

D11 973.2 Low oxygen affinity hemoglobin solution 

increases oxygenation of partially ischemic tissues during 

acute anemia. P. Cabrales. UCSD. 

D12 973.3 Oscillations in microvessel networks with RBC 

suspensions: preliminary in vitro experimental results in a 

3-node network. R.T. Carr, M. Maher and J.B. Geddes. Univ. 

of New Hampshire and F.W. Olin Col., MA. 

D13 973.4 Rate of oxygen disappearance from arterioles 

in rat mesentery measured with scanning phosphorescence 

quenching microscopy. A.S. Golub, B.K. Song and R.N. 

Pittman. Virginia Commonwealth Univ. 

D14 973.5 Efficacy of parallel capillary arrays in modelling 

oxygen transport in discrete microvascular networks. G.M. 

Fraser, D. Goldman and C.G. Ellis. Univ. of Western Ontario. 

D15 973.6 Simulation of metabolism-perfusion matching 

in a heterogeneous microvascular network. T.K. Roy, M.J. 

Joyner and T.W. Secomb. Mayo Clin. and Univ. of Arizona. 

D16 973.7 Distinct phenotypes after cell-specific deletion 

of Cx40: loss in endothelial cells impairs conduction in arterioles 

and loss in renin-producing cells elevates blood pressure. A. 

Jobs, A. Kurtz and C. de Wit. Univ. of Lübeck and Univ. of 

Regensburg, Germany. 

D17 973.8 Exercise training improves oxygen consumption 

and exercise performance in obese Zucker rats. L.B. Jones, 

W.L. Fuller, L. Xiang and R. Hester. Univ. of Mississippi Med. 

Ctr. 

D18 973.9 Impaired arteriolar constriction to hemorrhage 

in obese Zucker rats with orthopedic trauma. L. Xiang, W.L. 

Fuller and L.B. Jones. Sch. of Med., Univ. of Mississippi Med. 

Ctr. 

297 

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Physiology 

D19 973.10 Effect of top-loading a hemoglobin-based 

oxygen carrier on mean arterial pressure, arteriolar diameter 

and tissue oxygenation. B.K. Song, W.N. Nugent, A.S. Golub, 

P.F. Moon-Massat and R.N. Pittman. Virginia Commonwealth 

Univ. and Naval Med. Res. Ctr., Silver Spring, MD. 

D20 973.11 Elucidating the sources of enhanced oxygen 

consumption during early reperfusion following skeletal muscle 

ischemia in the rat spinotrapezius muscle. W.N. Nugent, A.S. 

Golub and R. Pittman. Virginia Commonwealth Univ. 

D21 973.12 Sphingosine-1-phosphate and endothelin-1 

cause vasoconstriction of inner ear capillaries. K. Reimann, 

E.Q. Scherer, W.G. Wier and P. Wangemann. Kansas State 

Univ., Tech Univ. of Munich and Univ. of Maryland Sch. of Med. 

D22 973.13 Investigating the hemodynamic parameters 

involved in microvasculature O 2 

regulation in skeletal muscle of 

Zucker diabetic fatty rat exposed to surface hypoxia. G.M. Dias, 

S. Milkovich, D. Goldman and C.G. Ellis. Univ. of Western 

Ontario. 

D23 973.14 Adenosine supersensitivity in coronary blood 

flow regulation. A.M. Hou and J.B. Bassingthwaighte. Univ. 

of Washington. 

D24 973.15 Inter-individual differences in arteriolar tree 

architecture in the mouse spinotrapezius may suggest a 

genetic basis for susceptibility to ischemic insult. A. Bruce, F. 

Mac Gabhann and S.M. Peirce. Univ. of Virginia. 

974. Microvascular Mechanics/ 

Hemodynamics/Remodeling 

Poster 




D25 974.1 Comparison of the microvascular network 

resistance between normotensive and spontaneously 

hypertensive rats. M. Yang, T. Jan and W.L. Murfee. Tulane 

Univ. 

D26 974.2 Modulation of NO bioavailability by temporal 

variability of cell-free layer width in the arterioles. P.K. Ong, 

S. Jain, P. Johnson and S. Kim. Natl. Univ. of Singapore and 

UCSD. 

D27 974.3 Inhibition of Rho kinase by Y27632 increases 

low oxygen tension-induced ATP release from human red 

blood cells. K. Thuet, E. Bowles, M. Sridharan, S. Adderley, 

R. Sprague and A. Stephenson. Saint Louis Univ. 

D28 974.4 An experimental and computational systems 

approach for studying how hemodynamics and bone marrowderived 

cells coordinate to regulate microvascular remodeling. 

S.S. Bajikar, J.K. Meisner and R.J. Price. Univ. of Virginia. 

D29 974.5 Estimation of effective reaction rate constant 

for NO-RBC reaction in microcirculation. P. Deonikar and M. 

Kavdia. Univ. of Arkansas. 

D30 974.6 Cellular mechanism and computational 

modeling of the conductive arterial hyperpolarization/dilation. 

Z-G. Jiang, F-Y. Chen and K-T. Ma. Oregon Hlth. & Sci. Univ. 

D31 974.7 Determinants of leukocyte margination 

in rectangular microchannels. L.L. Munn and A. Jain. 

Massachusetts Gen. Hosp., Charlestown and Boston Univ. 

D32 974.8 A hematocrit-dependent red blood cell 

exclusion zone (No Fly Zone) is present at the wall of arterioles. 

O. Yalcin, M. Jivani, M. Intaglietta and P. Johnson. UCSD. 


D33 974.9 Effect of systemic hematocrit on volume flow 

and cell free layer width in arterioles. S.E. Gorski, O. Yalcin, M. 

Jivani, M. Intaglietta and P.C. Johnson. UCSD. 

975. Permeability/Fluid and Solute 

Exchange/Glycocalyx 

Poster 




D34 975.1 Cellular mechanisms of hydrogen peroxide 

(H 2 

O 2 

)-induced permeability increases in intact venules: role 

of H 2 

O 2 

-induced Ca 2+ -independent nitric oxide production in 

endothelial cells. X. Zhou and P. He. West Virginia Univ. Hlath. 

Sci. Ctr. 

D35 975.2 Sphingosine 1-phosphate prevents platelet 

activating factor-induced permeability increases by activation 

of Rac-1 signaling in intact venules. G. Zhang, X. Zhou and P. 

He. Hlth. Sci. Ctr., West Virginia Univ. 

D36 975.3 Sphingosine-1-phosphate attenuation of acute 

inflammatory response versus reactive oxygen generation in 

rat microvessels. R.H. Adamson, R.K. Sarai, A. Altangerel, 

J.F. Clark and F.E. Curry. Univ. of California, Davis. 

D37 975.4 Sex-dependent influence of insulin (regular and 

fast) on in vivo albumin and protein clearance. S. Bingaman 

and V.H. Huxley. Univ. of Missouri Med. Sch. and Natl. Ctr. for 

Gender Physiol., Columbia, MO. 

D38 975.5 Phosphodiesterase IV inhibitor rolipram 

attenuates ANP-dependent intravascular fluid loss. Y-C. Lin, 

J.F. Clark, R.H. Adamson and F.E. Curry. Univ. of California, 

Davis Sch. of Med. 

D39 975.6 Rnd3 modulates the balance of RhoA and 

Rac1 activity during thrombin-induced hyperpermeability. K.M. 

Kurtz, T.M. Doggett and J.W. Breslin. LSU Hlth. Sci. Ctr. Sch. 

of Med., New Orleans. 

D40 975.7 GFP-actin dynamics during histamine-induced 

endothelial barrier dysfunction. J.W. Breslin, D.A. Maietta, 

K.M. Kurtz, T.M. Doggett, F.M. Souza and R.A. Worthylake. 

LSU Hlth. Sci. Ctr. Sch. of Med., New Orleans. 

D41 975.8 Loss of glycocalyx barrier properties impairs 

insulin-mediated recruitment of microvascular blood volume in 

rat hind limb muscle. B. Eskens, H. Cobelens, H. Vink and J. 

VanTeeffelen. Maastricht Univ., Netherlands. 

D42 975.9 A compartment model to evaluate the 

permeability of gap junctions between tenocytes in tendon 

fascicles. S. Ye, E. Maeda, M. Knight, D. Lee, D. Bader and W. 

Wang. Sch. of Engin. and Materials Sci., Queen Mary Univ. of 

London. 

D43 975.10 Prolyl hydroxylase inhibition attenuates 

hypoxia-induced hyperpermeability via iNOS upregulation. J.G. 

Wood, M. Moncure, J.H. Thomas, N.B. Holloway and N.C. 

Gonzalez. Univ. of Kansas Med. Ctr. 

D44 975.11 Enhanced acute responses to inflammatory 

stimuli at early stage of microvessel remodeling. D. Yuan, X. 

Zhou and P. He. West Virginia Univ. Hlth. Sci. Ctr. 

D45 975.12 Measurements of isolated glomerular albumin 

permeability do not change in a variety of proteinuric conditions. 

L.M. Sage, J. Ferguson, C.R. Neal, S.J. Harper, D.O. Bates 

and A.H.J. Salmon. Univ. of Bristol. 

298

tuesday 

D46 975.13 Systemic clearance of fluorescent dextrans 

after hemorrhage in rats. H. Carvalho, A.R. Woodruff, K.L. 

Simmons and R.N. Pittman. Virginia Commonwealth Univ. 

D47 975.14 Shear stress L p 

response enhanced by 

chondroitin sulfate and hyaluronic acid is Rho kinase dependent. 

R.H. Adamson, R.K. Sarai, A. Altangerel, J.F. Clark and F.E. 

Curry. Univ. of California, Davis. 

D48 975.15 Role of endothelial surface layer in mediation 

of flow-induced dilation of isolated arterioles. A. Marki, E. Gara, 

Z. Veresh, L. Seress, P. Toth and A. Koller. Semmelweis Univ. 

and Univ. of Pecs, Hungary and New York Med. Col. 

D49 975.16 Platelet activating factor induces S-nitrosylation 

of signalling proteins in an endothelial cell line. F.G. González, 

F.A. Sánchez, V. Velarde, M.P. Boric and W.N. Durán. UMDNJ- 

New Jersey Med. Sch., Pontificia Univ. Catolica de Chile and 

Univ. Austral de Chile. 

D50 975.17 Transendothelial transport may determine 

adiponectin oligomer functions. J.M. Rutkowski and P.E. 

Scherer. Univ. of Texas Southwestern Med. Ctr. 

D51 975.18 Na-K-ATPase activity involved in noise induced 

blood-labyrinth-barrier leakage. X. Shi and A.L. Nuttall. Oregon 

Hlth. & Sci. Univ. 

976. Vasomotor Control: Endothelium/ 

Smooth Muscle/Nerves 

Poster 




D52 976.1 Flow/shear stress-induced constriction of 

rat middle cerebral artery. P. Toth, Z. Vamos, Z. Springo, S. 

Komoly, T. Doczi and A. Koller. New York Med. Col. and Univ. 

of Pecs, Hungary. 

D53 976.2 Ankyrin-B is a critical determinant of vasomotor 

function. S.R. Cunha, P.J. Mohler and J.D. Miller. Univ. of Iowa 

and Mayo Clin. 

D54 976.3 Glycated proteins inhibit K channels in isolated 

vascular smooth muscle cells. Y. Yang, S.T. de Dios, A.J. 

Jenkins, M.J. Davis and M.A. Hill. Univ. of Missouri-Columbia 

and Univ. of Melbourne. 

D55 976.4 The effects of acute treatment with low doses 

of arsenic on vasoconstrictor and vasodilator responses 

of thoracic aorta from rats. K.M. Brooks, W.E. Rodriguez- 

Alvarez, J.T. Fleming and I.G. Joshua. Tennessee State Univ. 

and Univ. of Louisville. 

D56 976.5 Functional adrenoreceptor distribution in 

arteriolar networks of mouse gluteus maximus muscle. A.W. 

Moore, W.F. Jackson and S.S. Segal. Univ. of Missouri- 

Columbia and Michigan State. 

D57 976.6 Role of 20-HETE in differential effects of high 

salt diet on resistance artery function in Dahl salt-sensitive 

(SS) rats and SS-5BN consomic rats. K. Beehner, J.R. Falck, 

R.J. Roman and J.H. Lombard. Med. Col. of Wisconsin and 

Univ. of Texas Southwestern Med. Ctr. 

D58 976.7 Salt-induced increase in 20-HETE production 

alters vascular function of mesenteric resistance arteries of 

Dahl salt-sensitive rats. G. Raffai, J. Wang, J.R. Falck, R.J. 

Roman and J.H. Lombard. Med. Col. of Wisconsin and Univ. 

of Texas Southwestern Med. Ctr. 

physiology 

D59 976.8 Functional response to endothelin in macroand 

microvascular endothelial cells. V. Shlyonsky, I. Ben 

Soussia, N. Cheriaa, R. Naeije and F. Mies. Univ. de Libré 

Brusells, Belgium. 

D60 976.9 Effect of juvenile growth on arteriolar eNOS 

phosphorylation. L.S. Kang, T.R. Nurkiewicz, G. Wu and M.A. 

Boegehold. West Virginia Univ. and Texas A&M Univ. 

D61 976.10 O-GlcNAc transferase inhibition does not 

improve renal artery function in male angiotensin II hypertensive 

rats. C.S. Rigsby, V.V. Lima, R.C. Webb and R.C. Tostes. Med. 

Col. of Georgia and Univ. of São Paulo. 

D62 976.11 Role of endothelial canonical transient 

receptor potential channels in ATP-mediated vasorelaxation. 

S.P. Marrelli, M.Y. Kochukov, R.C. Noel, M.M. Mbaka and J. 

Chen. Baylor Col. of Med. 

D63 976.12 Caveolin-1 limits the contribution of BK(Ca) 

channel to EDHF-mediated arteriolar dilation. A. Feher, N. 

Labinskyy and Z. Bagi. New York Med. Col. 

D64 976.13 Diabetic pregnancy impairs EDHF-dependent 

uteroplacental vasodilation mediated by intermediateconductance 

Ca 2+ -activated K + channels. N.I. Gokina, O.Y. 

Kuzina, A.M. Vance and J.K. Phillips. Univ. of Vermont. 

D65 976.14 Microprojections amplify EC response to SMC 

stimulation: a theoretical study. S. Nagaraja, A. Kapela and N. 

Tsoukias. Florida Intl. Univ. 

D66 976.15 Sympathetic modulation of baseline hindlimb 

blood flow and vascular conductance in a model of prediabetes 

using young Zucker diabetic fatty rats. N.M. Novielli, B.K. 

Al-Khazraji, C.G. Ellis and D.N. Jackson. Univ. of Western 

Ontario. 

D67 976.16 The a2 isoform of the Na,K-pump is involved 

in synchronization of smooth muscle cells in the arterial wall. 

C. Aalkjær, N. Møller-Nielsen and V. Matchkov. Aarhus Univ., 

Denmark. 

D68 976.17 Steady-state decrease of smooth muscle 

cell and endothelial cell pH prevents hypertension induced 

by angiotensin II or NO-synthase inhibition. C. Aalkjær, E. 

Bødtkjer and J. Praetorius. Aarhus Univ., Denmark. 

D69 976.18 Deletion of myostatin improves cardiac and 

vascular function in mice. D.W. Stepp, M.I. Ali, E.J. Belin de 

Chantemele, L. Germany, J. Mintz and J.M. Osmond. Med. 

Col. of Georgia. 

D70 976.19 Key role of Ca 2+ -activated K + channels of small 

and intermediate conductance in the NO signaling of resistance 

vessels. P.S. Gaete and X.F. Figueroa. Pontifical Catholic Univ. 

of Chile. 

977. Blood Pressure Regulation III 

Poster 



D71 977.1 Chronic treatment with propranolol does not 

alter sympathetic and cardiovagal baroreflex sensitivity in 

the postural orthostatic tachycardia syndrome. Q. Fu, T.B. 

VanGundy, M.M. Galbreath, S. Shibata, S.S. Jarvis and B.D. 

Levine. IEEM and Univ. of Texas Southwestern Med. Ctr. 

D72 977.2 Activation of adenosine A 2A 

receptors causes 

hypotension in newborn but not adult rats. J.M. Abu-Shaweesh. 

Case Western Reserve Univ. 

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Physiology 

D73 977.3 Carotid baroreflex function in African Americans 

at rest. D. Fulton, T.G. Hodge, K. Vespoli and D.M. Keller. 

Univ. of Texas at Arlington. 

D74 977.4 Salt induced vascular response through 

adenosine A 2A 

receptor: role of CYP epoxygenase and 

soluble epoxide hydrolase. M.A. Nayeem, D.C. Zeldin, M.A. 

Boegehold, D.S. Ponnoth, K.P. Roush and J.R. Falck. West 

Virginia Univ.NIEHS, NIH, Research Triangle Park and Univ. of 

Texas, Dallas. 

D75 977.5 Pressor and baroreflex effects of ouabain in 

(mRen2)27 and mRen2.Lewis rats. E. Logan, A. Johnson, D. 

Diz and A. Aileru. Winston Salem State Univ. and Wake Forest 


D76 977.6 Effects of chronic melatonin treatment in 

renovascular hypertension. V.R. Almeida, F.R. Almeida, M.L. 

Andersen, R.R. Campos and C.T. Bergamaschi. Fed. Univ. of 

São Paulo. 

D77 977.7 A novel solid state telemetry sensor for the 

chronic measurement of pressure in rats. M. Lim, B. Pauly, 

D. McCormick, R. Kirton, D. Budgett, M. Kondo, S-J. Guild, 

C.J. Barrett and S.C. Malpas. Telemetry Res. Ltd., Auckland, 

Millar Instruments Inc., Houston and Univ. of Auckland. 

D78 977.8 Hemodynamic effects of torcetrapib and 

cardiotonic steroids in rats. X. Ma, H. Zhao and M.J. Forrest. 

Merck Res. Labs. 

D79 977.9 Greater orthostatic tolerance in young black 

compared to white women. K. Hinds and N. Stachenfeld. 

John B. Pierce Lab. and Yale Univ. Sch. of Med. 

D80 977.10 The aortic and carotid sinus baroreflexes 

contribute equally to control blood pressure and heart rate 

variabilities. X. Tang, T. Hu and J.S. Snyder. Penn State Col. of 

Med. and Wesleyan Univ. 

978. Cardiovascular Consequences of the 

Metabolic Syndrome 

Poster 



D81 978.1 Altered spatio-temporal microvascular blood 

flow distribution patterns in skeletal muscle with metabolic 

syndrome. J.C. Frisbee, F. Wu and D.A. Beard. West Virginia 

Univ. Hlth. Sci. Ctr. and Med. Col. of Wisconsin. 

D82 978.2 A stochastic model of flow bifurcation predicts 

altered spatial flow distributions in obese Zucker rats. F. Wu, 

J.C. Frisbee and D.A. Beard. Med. Col. of Wisconsin and West 

Virginia Univ. Hlth. Sci. Ctr. 

D83 978.3 Reduced leptin and resistin and increased 

adiponectin are associated with improved endothelial function 

during weight loss with low fat compared to low carbohydrate 

diets. S.A. Phillips, J-T. Bian, S. Bhutani and K.A. Varady. 

Univ. of Illinois at Chicago. 

D84 978.4 Store-operated Ca 2+ influx predicts coronary 

artery disease and is induced by dyslipidemia in metabolic 

syndrome and type 2 diabetes. Z.P. Neeb, M. Alloosh, J. 

Edwards, I.N. Bratz and M. Sturek. Indiana Univ. Sch. of Med. 

and Northeastern Ohio Univs. Col. of Med. 

D85 978.5 Epicardial perivascular adipose tissue 

exacerbates coronary endothelial dysfunction in metabolic 

syndrome via leptin-induced activation of PKC-b. G.A. Payne, 

L. Borbouse, S. Kumar, Z.P. Neeb, M. Alloosh, M. Sturek 

and J.D. Tune. Indiana Univ. Sch. of Med. 


D86 978.6 Mitochondria mediated vasodilation by BMS- 

191095, a selective mitochondrial K ATP 

channel activator. P.V.G. 

Katakam, M.M. Steed, J.A. Snipes and D.W. Busija. Wake 

Forest Univ. Hlth. Sci. 

D87 978.7 Cerebrovascular reactivity after experimental 

subarachnoid hemorrhage in insulin resistant rats. A. Institoris, 

F. Domoki, F. Bari and D.W. Busija. Wake Forest Univ. Hlth. 

Sci. and Univ. of Szeged, Hungary. 

D88 978.8 Elevated glucose compromises myocardial 

mitochondrial DNA integrity by activation of mitochondrial 

topoisomerase activity. J.G. Edwards, S. Medikayala, B. Piteo 

and N. Labinskyy. New York Med. Col. 

D89 978.9 Impaired mesenteric resistance artery 

relaxation to KATP channel activation in cardiometabolic 

syndrome is improved by rosiglitazone treatment. K.A. Walsh, 

M.A. Carpenter and J.D. Imig. Med. Col. of Wisconsin. 

D90 978.10 Attenuated endothelin-1 vasoconstrictor 

responses in cardiometabolic syndrome are attributed to 

increased ET-B receptors. D. Wallace, K.A. Walsh and J.D. 

Imig. Med. Col. of Wisconsin. 

D91 978.11 Myostatin gene knockout improves endothelium 

dependent dilation in coronary arteries of obese mice. M.I. Ali, 

J.D. Mintz, M. Hamrick, D.J. Fulton and D.W. Stepp. Med. 

Col. of Georgia. 

D92 978.12 Role of arterial TRPV1 channels in metabolic 

syndrome. V.A. Ohanyan, P.E. Shamheart, G. Guarini, P.K. 

Talasila and I.N. Bratz. Northeastern Ohio Univs. Col. of 

Med. 

D93 978.13 Insulin resistance mediated changes in matrix 

metalloproteinase expression and activity in diverse vascular 

beds. M.M. Steed, P.V. Katakam and D.W. Busija. Wake 

Forest Univ. Hlth. Sci. 

D94 978.14 Flow-mediated, redox-dependent AT1R 

regulation determines collateral growth capacity. J.L. Unthank, 

S.J. Miller and C.A. Labarrere. Indiana Univ. and Clarian Hlth., 

Indianapolis. 

D95 978.15 The tempo of cardiovascular and metabolic 

responses to fasting is different between lean and obese mice. 

J. Tanner, D. Kearns, B.J. Kim, C. Sloan, G. Yang, Z. Jia, T. 

Yang, E.D. Abel and J.D. Symons. Col. of Hlth. and Sch. of 

Med., Univ. of Utah. 

D96 978.16 Ceramide-induced disruption of endothelial 

nitric oxide synthase dimerization in bovine aortic endothelial 

cells is not secondary to peroxynitrite formation. L. Wilson, 

Q. Zhang, C. Arrant, D. Pettey, C. Kowalski, D. McCamey, 

C. Boehme, W. Baker, R.N. Soorappan, E.D. Abel and J.D. 

Symons. Univ. of Utah. 

D97 978.17 Hsp90 inhibition leads to the degradation of 

O-linked N-acetylglucosamine transferase and to the reduction 

of O-GlcNAcylation. F. Zhang, C. Snead, A.S. Chang and J.D. 

Catravas. Med. Col. of Georgia. 

D98 978.18 O-GlcNAc signaling regulates cardiac 

hypertrophy via NFAT activation. H.T.F. Facundo, R.E. Brainard 

and S.P. Jones. Univ. of Louisville. 

D99 978.19 Role of dicer in diabetic cardiomyopathy 

through dysregulation of MMP-9 and TIMP-4. P.K. Mishra, S. 

Givvimani, U. Sen, O.A. Abe, N. Tyagi, P. Basu, C. Munjal 

and S.C. Tyagi. Univ. of Louisville. 

D100 978.20 Polyol pathway contributes to the acute 

hyperglycemia-induced contractile dysfunction in perfused 

heart from rat. W.H. Tang, W.T. Cheng, S.K. Chung and S.M.S. 

Chung. Univ. of Hong Kong. 

300

tuesday 

D101 978.21 Differences in the cardiac proteome in rats 

selected for either low or high running capacity. J. Burniston, 

J. Kenyani, J. Wastling, L. Koch and S.L. Britton. Liverpool 

John Moores Univ., Sch. of Vet. Sci., Univ. of Liverpool and 

Univ. of Michigan. 

D102 978.22 Diosgenin supress cardiac apoptosis and 

enhance survival pathway in ovariectomized rats. S-D. Lee, C-Y. 

Tasi, H-C. Ou and C-Y. Huang. China Med. Univ., Taiwan. 

D103 978.23 The ZDSD, a new rat model of metabolic 

syndrome: evidence of cardiovascular disease. C.S. Packer, 

L.M. Meulen, A.M. Boice, K. Coy and R.G. Peterson. Indiana 

Univ. Sch. of Med. and PreClinOmics, Indianapolis. 

D104 978.24 The ZDSD, a new rat model of metabolic 

syndrome: altered arterial muscle mechanics. C.S. Packer, 

A.M. Boice, L.M. Meulen, K. Coy and R.G. Peterson. Indiana 

Univ. Sch. of Med. and PreClinOmics, Indianapolis. 

D105 978.25 Niacin reduces renal damage and insulin 

insensitivity in Charles River obese SHR (SHROB/cp): a model 

of the metabolic syndrome. Y-J. Kang, T. Manero, S. Levine, 

D. Owens, P. Chander and C. Stier. New York Med. Col., 

Nathan Kline Inst., Orangeburg, NY and Charles River Labs., 

Wilmington, MA. 

D106 978.26 Telmisartan improves cognitive function 

through the increase in neurotrophic factor and inhibition of 

apoptosis in hippocampus of rats with metabolic syndrome. T. 

Kishi, Y. Hirooka and K. Sunagawa. Kyushu Univ. Grad. Sch. 

of Med. Sci., Japan. 

979. Cerebral Circulation I 

Poster 



D107 979.1 Canrenoic acid, a mineralocorticoid receptor 

antagonist, attenuates resistance artery remodeling in strokeprone 

spontaneous hypertensive rats. P.W. Pires, J.L. McClain 

and A.M. Dorrance. Michigan State Univ. 

D108 979.2 Postnatal maturation and hypoxic acclimatization 

modulate PKG-mediated activation of BK channels in ovine 

cerebral arteries. J.M. Williams, S.L. Stockman, T.M. Lincoln 

and W.J. Pearce. Loma Linda Univ. Sch. of Med. and Univ. of 

Southern Alabama Col. of Med. 

D109 979.3 Involuntary breathing movements improve 

cerebral oxygenation during apnea struggle phase in elite 

divers. Z. Dujic, L. Uglesic, T. Breskovic, Z. Valic, K. Heusser, 

J. Marinovic, M. Ljubkovic and I. Palada. Univ. of Split Sch. of 

Med., Croatia and Hannover Med. Sch., Germany. 

D110 979.4 Inhibition of PPARg during pregnancy causes 

inward remodeling of brain parenchymal arterioles. M.J. 

Cipolla, S-L. Chan, A.C. Chapman and J.A. Godfrey. Univ. of 

Vermont. 

D111 979.5 Role of cAMP and cGMP in arachidonic acid 

and PGE2-induced cerebral vasodilation in newborn pigs. 

A.J. Kanu and C.W. Leffler. Univ. of Tennessee Hlth. Sci. Ctr., 

Memphis. 

D112 979.6 PPARa agonists acutely dilate the mouse 

middle cerebral artery. N.K. Parelkar, M.Z. Badr and J. 

Andresen. Sch. of Med. and Sch. of Pharm., Univ. of Missouri- 

Kansas City. 

physiology 

D113 979.7 Indication for cholinergically mediated cerebral 

vasodilatation during static exercise in humans. T. Seifert, J.P. 

Fisher, C.N. Young, D. Hartwich, P.J. Fadel and N.H. Secher. 

Univ. of Copenhagen, Sch. of Sport & Exercise Sci., Univ. of 

Birmingham, UK and Univ. of Missouri-Columbia. 

D114 979.8 Akt/Bcl-2 signaling is critical for anti-apoptotic 

effects of carbon monoxide against TNF-alpha-mediated 

inflammatory damage in cerebral vascular endothelial cells. S. 

Basuroy, S. Bhattacharya, C.W. Leffler and H. Parfenova. 

Univ. of Tennessee Hlth. Sci. Ctr., Memphis. 

980. Coordinate Regulation of Vascular 

Smooth Muscle Gene Expression, Cell 

Phenotype, and Vessel Function 

Poster 



D115 980.1 Cyclosporine upregulates KLF4 in vascular 

smooth muscle cells and drives phenotypic modulation in vivo. 

D.S. Sinden, S.M. Garvey, D.L. Rose, P.D. Schoppee Bortz, 

M.Y. Lee and B.R. Wamhoff. Univ. of Virginia. 

D116 980.2 Genomics approach using calcineurin/NFAT 

inhibitors to identify novel effectors of vascular smooth muscle 

phenotypic modulation. M.Y. Lee, S.M. Garvey and B.R. 

Wamhoff. Univ. of Virginia. 

D117 980.3 Sphingosine kinase 1 is required for smooth 

muscle cell phenotypic modulation in response to vascular 

injury. B.R. Wamhoff, T. Matthews, J. Hogan, A. Morris, Y. 

Karel, T. Macdonald and K.R. Lynch. Univ of Virginia and 


D118 980.4 Nuclear factor of activated T cells regulates 

osteopontin expression in arterial smooth muscle in response 

to diabetes-induced hyperglycemia. M.F. Gomez, L.M. 

Nilsson-Berglund, A.V. Zetterqvist, J. Nilsson-Öhman, M. 

Sigvardsson, L.V. Gonzalez-Bosc, M-L. Smith, A. Salehi, 

E. Agardh, G. Nordin-Fredrikson, C-D. Agardh, J. Nilsson, 

B.R. Wamhoff and A. Hultgårdh-Nilsson. Lund Univ. and 

Linköping Univ., Sweden, Univ. of New Mexico and Univ. of 

Virginia. 

D119 980.5 NFAT5 positively regulates SMaA gene 

expression in vascular smooth muscle. J.A. Lemmon, H.M. 

Kwon and B.R. Wamhoff. Univ. of Virginia and Univ. of 

Maryland Baltimore. 

D120 980.6 Interference with peroxisome proliferator 

activated receptor gamma in smooth muscle causes aortic 

dysfunction via a Rho-kinase-dependent mechanism. C.J. 

Pelham, P. Ketsawatsomkron, S. Groh, W.J. de Lange, F.M. 

Faraci and C.D. Sigmund. Univ. of Iowa. 

D121 980.7 In P14 rat middle cerebral arteries relations 

between myogenic tone and cytosolic Ca 2+ are enhanced by 

myofilament Ca 2+ sensitization and increased Ca 2+ influx, but 

attenuated by high proportions of noncontractile smooth m 

S.M. Charles, L. Zhang, M.J. Cipolla, J.N. Buchholz and W.J. 

Pearce. Loma Linda Univ. Sch. of Med. and Univ. of Vermont 

Col. of Med. 

D122 980.8 Phenotypic differences between neonatal and 

adult ovine carotid arteries predict reactivity to chronic hypoxia 

and VEGF. O.O. Adeoye, S.M. Butler, J.M. Abrassart, E.A. 

Mock, J.M. Williams and W.J. Pearce. Loma Linda Univ. Sch. 

of Med. 

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Physiology 

981. Diabetes and Insulin Resistance III 

Poster 



D123 981.1 The role of nitric oxide in the urine concentration 

mechanism in diabetic rats. P. Cipriani, S.L. Kim, J.D. Klein, 

C.E. Denson, J.H. Sim, J.M. Sands and M.A. Blount. Emory 

Univ. 

D124 981.2 Proliferation of macula densa cells in response 

to succinate. B.E. Blebu, I. Toma, S.L. Vargas, J.J. Koo and J. 

Peti-Peterdi. Univ. of Southern California. 

D125 981.3 Modulation of PI3-K/AKT pathway by reninangiotensin 

system inhibition in obesity experimental model. 

D.S. Carvalho, E.S. Alves, A.A. Haidar, C.D. Quadros, D. 

Morgan, M.S. Rocha, A.R. Carpinelli and A.E. Hirata. Fed. 

Univ. of São Paull and Univ. of São Paulo. 

D126 981.4 Gender-specific regulation of hepatic 

aquaglyceroporin 9 and glycerol kinase expression. J. Lebeck, 

S.A. Lund and J. Praetorius. Aarhus Univ. and Hosp., 

Denmark. 

D127 981.5 Correlativity between the plasma homocysteine 

and endogenous carbon monoxide of penile corpus cavernosum 

in type 2 diabetes. W-B. Qin, H-W. Xu, Y-M. Kang, B-J. Chi, 

X-D. Wei, S-Q. Wang and J-X. Liu. Jiamusi Univ. and Shanxi 

Med. Univ., People’s Republic of China and LSU. 

D128 981.6 Retinal reactivity in type 2 diabetics. M.E.J. 

Lott, K. Bettermann, J. Slocumb, B. Smith, T. Gardner and 

R. Gabbay. Penn State Hershey Med. Ctr. 

D129 981.7 Cardiac sympathetic activity assessed by heart 

rate variability indicates myocardial ischemia on cold exposure 

in diabetes. K. Sasaki, S. Matsushita and Y. Sakakibara. Sch. 

of Med., Univ. of Tsukuba, Japan. 

D130 981.8 Aldose reductase deficiency enhances high fat 

diet-induced hyperinsulinemia and endothelial dysfunction. I. 

Mehta, D. Conklin, S. Srivastava and A. Bhatnagar. Univ. of 

Louisville. 

D131 981.9 Exacerbation of endothelial dysfunction in 

aged diabetic mice. Y-M. Yang, A. Huang, H. Wu, Z. Bagi, G. 

Kaley and D. Sun. New York Med. Col. 

D132 981.10 The isolation of the receptor for advanced 

glycation end-products from avian vasculature. E.N. Cousens 

and E.J. Braun. Univ. of Arizona. 

D133 981.11 Folic acid attenuates vascular dysfunction in 

type-2 diabetic mice. R.A. Lawal, W.E. Rodriguez-Alvarez, 

S.C. Tyagi and I.G. Joshua. Univ. of Louisville. 

982. Hypertension II 

Poster 



D134 982.1 Functional and molecular characterization 

of vascular TREK-1 channel and its role in EDHF-mediated 

vasodilation and hypertension. B.P. Kaistha, C. Busch, A. 

Kaistha, M. Kacik, R. Köhler and J. Hoyer. Philipps Univ. 

Marburg, Germany. 

D135 982.2 Endothelin-1 and the metalloproteases ECE and 

NEP in DOCA-salt hypertensive rats. J. Nelissen, P. Lemkens, 

J. Debets, H. van Essen, J. Bost, P. Schiffers, J.G.R. De Mey 

and B.J.A. Janssen. Maastricht Univ., Netherlands. 


D136 982.3 Increased decorin mRNA expression leads 

to larger collagen fibril diameter in SHR kidney cortex. T. 

Skogstrand, S. Leh, I. Moen, L.E.B. Stuhr, R. Reed, B.M. 

Iversen and M. Hultström. Univ. of Bergen and Haukeland 

Univ. Hosp., Norway. 

D137 982.4 Elevated sympathetic activity precedes the 

arterial hypertension in the Goldblatt model. E.B. Oliveira- 

Sales, A.P.L. Abdala, E. Colombari, R.R. Campos and J.F.R. 

Paton. Fed. Univ. of São Paulo and Univ. of Bristol. 

D138 982.5 Dipeptidyl peptidase IV inhibition attenuates 

blood pressure rising in young spontaneously hypertensive 

rats. B.P.M. Pacheco, R.O. Crajoinas, G.K. Couto, A.P.C. 

Davel, L.V. Rossoni and A.C.C. Girardi. Univ. of São Paulo. 

D139 982.6 Tissue angiotensin II type 1 receptor expression 

in development of hypertension in SHR/Brown Norway congenic 

rats. J.A. Collett, A. Ighodaro, E. Patterson and J.L. Osborn. 


D140 982.7 Preventive effects of exercise training on 

dexamethasone-induced hypertension, oxidative stress and 

peripheral insulin resistance. S.L. Amaral, O.A.B. Perez, 

M. Barel, L.R. Bechara, L.Y. Tanaka, T.J. Dionísio, J.C. 

Louzada, E.J. Dionísio, B.A. Viscelli, A.M. Martuscelli, J.R. 

Bosqueiro, C.F. Santos and P.R. Ramires. São Paulo State 

Univ., HCFMUSP, Bauru, Brazil and Univ. of São Paulo. 

D141 982.8 Development of auditory deficits in a rat model 

of placental insufficiency. J.S. Gilbert, E.L.B. Soldner and J.L. 

Fitzakerley. Univ. of Minnesota Med. Sch., Duluth. 

D142 982.9 Effect of intracerebroventricular and 

subcutaneous benzmail administration on AngII-salt 

hypertension. D.M. Hirsch, P.A. Guzman, M. Rodriguez, G. 

Toney and J.W. Osborn. Univ. of Minnesota, Minneapolis and 

Univ. of Texas at San Antonio. 

D143 982.10 Arterial compliance in untreated hypertensive 

elderly: implications for gender differences. M. Galbreath, 

S. Shibata, T.B. VanGundy, R.L. Meier, S.S. Jarvis, W. 

Vongpatanasin, B.D. Levine and Q. Fu. IEEM, Dallas and 

Univ. of Texas Southwestern Med. Ctr. 

D144 982.11 Synaptic transmission in the inferior mesenteric 

ganglion of hypertensive and normotensive rats. T. Houchin 

and D. Kreulen. Michigan State Univ. 

D145 982.12 Salt sensitive hypertension associated with 

stem cell defect in the renal medulla of Dahl S rats. Z. Wang, M. 

Xia, Q. Zhu, P-L. Li and N. Li. Virginia Commonwealth Univ. 

D146 982.13 Overexpression of HIF-1a transgene in the 

renal medulla attenuated salt-sensitive hypertension in Dahl S 

rats. Q. Zhu, Z. Wang, M. Xia, P-L. Li, F. Zhang and N. Li. Med. 

Col. of Virginia, VCU. 

D147 982.14 Indomethacin enhances reactivity to 

vasopressin in normotensive and hypertensive rats, while PGE 2 

receptor blockade only attenuates reactivity in normotensive 

rats. M.M. Sellers and J.N. Stallone. Texas A&M Univ. 

D148 982.15 Antenatal protein deprivation in the mouse: 

epigenetic changes and developmental origin of hypertension 

in adult. R. Goyal, A. Leitzke, D. Goyal and L.D. Longo. Loma 

Linda Univ. 

D149 982.16 Involvement of activation of Janus kinase 2 in the 

mechanisms utilized by norepinephrine to cause hypertension. 

H. Al-Azawi, D. Proctor, D. Elhout, M.W. Brands and A.K.L. 

Banes-Berceli. Oakland Univ. and Med. Col. of Georgia. 

D150 982.17 The relationship between blood pressure and 

arterial characteristics in clinically normotensive children. A.A. 

Phillips, J. Peralta-Huertas, L.K. Fitzgibbon, T. Wade, J. 

Cairney and D. O’Leary. Univ. of British Columbia, Brock Univ. 

and McMaster Univ., Canada. 

302

tuesday 

D151 982.18 Pregnancy and pseudopregnancy: physiological 

states with high endogenous ouabain, coexistent suppression 

of maternal arterial myocyte NCX and a2 Na + pumps, and 

resistance to ouabain-induced hypertension. B.E. Jacobs, Y. 

Liu, A.M. Zulian, V.A. Golovina and J.M. Hamlyn. Univ. of 

Maryland Baltimore. 

983. Wiggers Award Featured Topic 

Posters: Hypertension, Inflammation, 

and Adaptive Immunity 

Poster 



D152 983.1 Inhibition of T cell costimulation prevents 

the development of hypertension. A. Vinh, L.A. McCann, Y. 

Blinder, D. Weiss, W.R. Taylor, J.J. Goronzy, C.M. Weyand, 

T.J. Guzik and D.G. Harrison. Emory Univ. Sch. of Med. and 

Jagiellonian Univ., Poland. 

D153 983.2 Inflammatory markers in isolated endothelial 

cells of the spontaneously hypertensive rat. R. Xiu, F.A. 

DeLano, L. Hongwei, L. Ailine and G.W. Schmid-Schönbein. 

Chinese Acad. of Med. Sci., Peking Union Med. Col., Beijing 

and UCSD. 

D154 983.3 Soluble epoxide hydrolase is involved in 

angiotensin II-induced atherosclerosis. L. Wen, D. Ai, B.D. 

Hammock, J.Y-J. Shyy and Y. Zhu. Peking Univ. Hlth. Sci. Ctr., 

Univ. of California, Riverside and Univ. of California, Davis. 

D155 983.4 Induction of hypertension and peripheral 

inflammation by deletion of extracellular superoxide dismutase 

in the central nervous system. H.E. Lob, P.J. Marvar, T.J. 

Guzik, C. Weyand, F.J. Gordon and D.G. Harrison. Emory 

Univ. Sch. of Med. and Jagiellonian Univ., Poland. 

D156 983.5 The effect of renal perfusion pressure on renal 

injury in hyperglycemic AngII hypertensive rats. C. Jin, A. 

Polichnowski, Y. Ohsaki and A.W. Cowley, Jr. Med. Col. of 

Wisconsin. 

D157 983.6 The coronary endothelium as a functional 

and physical barrier for endocrine angiotensin II. D.T. Tirado, 

J.C. Hernandez, E.C. Ahumada, J.R. Diaz and R. Rubio. 

Autonomous Univ. of San Luis Potosi Fac. of Med., Mexico. 

984. Nitric Oxide/Carbon Monoxide/ 

Vasoactive Molecules 

Poster 



D158 984.1 Chronic blockade of endogenous formation of 

hydrogen sulfide caused increase in systemic blood pressure 

in rats. M.A.H. Khan, A.P. Roy, M.T. Islam and D.S.A. Majid. 

Tulane Univ. 

D159 984.2 Novel mechanisms of activation of endothelial 

nitric oxide synthase mediated by endothelial transient receptor 

potential vanilloid type 1. L-C. Ching, Y.R. Kou, C-C. Pan and 

T-S. Lee. Natl. Yang-Ming Univ., Taiwan. 

physiology 

D160 984.3 The nitric oxide (NO) donors [Ru(terpy)(bdq) 

NO + ]3 + and sodium nitroprusside have different cellular effects 

in rat basilar arteries relaxation. M. Paulo, J.A. Vercesi, J.C. 

Biazzotto, R.S. da Silva and L.M. Bendhack. Univ. of São 

Paulo, Ribeirão Preto. 

D161 984.4 Nitric oxide (NO) released from NO donors has 

hypotensive effect and it induces rat aorta relaxation due to the 

activation of K + channels, guanylyl-cyclase and SERCA. A.C. 

Pereira, J.A. Vercesi, J.C. Biazzotto, R.S. da Silva and L.M. 

Bendhack. Univ. of São Paulo, Ribeirão Preto. 

D162 984.5 The contribution of guanylyl cyclase and 

potassium channels to the relaxation induced by the NO 

donors [Ru(terpy)(bdq)NO + ]3 + and sodium nitroprusside in 

rat mesenteric resistance arteries. A.V. Araújo, J.A. Vercesi, 

J.C. Biazzotto, R.S. da Silva and L.M. Bendack. Univ. of São 

Paulo, Ribeirão Preto. 

D163 984.6 Vasodilatation induced by a new NO 

donor involve KCa channels activation and cell membrane 

hyperpolarization. C.N. Lunardi, A.C. Pereira, J.C. Biazzotto, 

R.S. da Silva and L.M. Bendhack. Univ. of Brasilia and Fac. of 

Pharmaceut. Sci. of Ribeirão Preto-Univ. of São Paulo. 

D164 984.7 Role of NO and the NADPH oxidase in 

hyperhomocysteinemia induced cardiac metabolic dysfunction 

in pregnancy. S. Song, H. Huang, B. Martin-Fernandez, C. 

Ojaimi, P. Kaminski, S. Zhang, Z. Wang, M. Wolin and T.H. 

Hintze. New York Med. Col. 

D165 984.8 Time-course effects of low salt diet on the 

regulation of cardiac NO bioactivity: role of NAD(P)H oxidase. 

Y.S. Skayian, S. Coffin, H. Huang, Z. Wang and T.H. Hintze. 

New York Med. Col. 

D166 984.9 Effect of membrane permeability and 

extracellular diffusion on NO uptake by erythrocytes. P. 

Deonikar and M. Kavdia. Univ. of Arkansas. 

D167 984.10 Role of NO in hyperuricemia induced cardiac 

metabolic dysfunction in pregnancy. B. Martin-Fernandez, S. 

Song, H-E. Huang and T.H. Hintze. New York Med. Col. 

D168 984.11 Lung arginase activity is increased in ovine 

model of acute lung injury and contributes to long-term 

pulmonary dysfunction. L.E. Sousse, Y. Yamamoto, P. 

Enkhbaatar, Y-M. Yu, S. Rehberg, L. Traber, D. Herndon and 

D. Traber. Univ. of Texas Med. Branch and Shriners Hosp. for 

Children, Boston and Galveston. 

D169 984.12 Carbon monoxide inhibits tubuloglomerular 

feedback in vivo by activation of soluble guanylyl cyclase. H. 

Wang, J.L. Garvin and O.A. Carretero. Henry Ford Hosp., 

Detroit. 

D170 984.13 Nitric oxide-mediated proteins’ S-nitrosation in 

endothelial cells under shear flow or rosuvastatin treatment. 

L.D. Wang and B. Huang. Inst. of Biomed. Sci., Acad. Sinica, 

Taipei. 

D171 984.14 The inhibition of NOS downregulates adenosine 

production in the interstitial space of rat skeletal muscle. Y. 

Zhao, A.A. Smith, S. Fabris and D.A. MacLean. Northern 

Ontario Sch. of Med. and Laurentian Univ., Canada. 

D172 984.15 Interstitial adenosine but not nitric oxide 

concentrations are elevated during systemic hypoxia in rat 

skeletal muscle. A.A. Smith, Y. Zhao, S. Fabris and D.A. 

MacLean. Northern Ontario Sch. of Med. and Laurentian Univ., 

Canada. 

D173 984.16 Caveolin-1 phosphorylation negatively 

regulates eNOS activity in endothelial cells. Z. Chen, G. Liu, F. 

Bakhshi, A.T. Place, T. Sharma, R.A. Skidgel, A.B. Malik and 

R.D. Minshall. Univ. of Illinois at Chicago. 

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D174 984.17 Molecular, biochemical characterization 

and localization of neuronal nitric oxide synthase in human 

neutrophil. A. Jyoti, R. Saluja, S. Kumar, M. Chatterjee, A. 

Verma, M.K. Barthwal, V.K. Bajpai and M. Dikshit. Central 

Drug Res. Inst., Lucknow, India. 

D175 984.18 Macrophage nitrite uptake and release. S. 

Kaimootil, C. Newell, T. Tran and J. Rodriguez. Centenary 

Col. of Louisiana. 

D176 984.19 Role of p38 MAPK in PMA-induced NETs 

release from human neutrophils. R.S. Keshari, S. Kumar, A. 

Jyoti, S. Patel, M.K. Barthwal, A. Verma, V.K. Bajpai and M. 

Dikshit. Central Drug Res. Inst., Lucknow, India. 

D177 984.20 Nitroxyl anion mediates vasorelaxation in saltloaded 

AngII hypertensive mesenteric arteries. B.M. Wynne, 

H. Labazi, R.C. Tostes and R.C. Webb. Med. Col. of Georgia 

and Univ. of São Paolo. 

D178 984.21 Nitric oxide enhances NFATc3 nuclear import 

and decreases export. L. Bettini, F. Albertoni-Borghese, M. 

Majowicz, N. Vidal and L.V. Gonzalez Bosc. Univ. of New 

Mexico and Univ. of Buenos Aires. 

D179 984.22 Kinetics of nitrosation of GSH using NO donors. 

K.J. Madrasi, M.S. Joshi and N. Tsoukias. Florida Intl. Univ. 

D180 984.23 Agmatine-mediated rat mesenteric artery 

relaxation via NO synthesis. T. Gadkari, Z. Acosta, N. Tsoukias 

and M.S. Joshi. Florida Intl. Univ. 

D181 984.24 Carbon monoxide, a heme oxygenase 

metabolite, decreases ATP release by macula densa cells 

in vitro. P. Leung, J.L. Garvin, R. Liu and O.A. Carretero. 

Henry Ford Hosp., Wayne State Univ. Sch. of Med. and Univ. of 

Mississippi Med. Ctr. 

985. Vascular Smooth Muscle II 

Poster 



D182 985.1 Vasoregulation by isoform-selective coupling 

of TRPC3 channels to IP 3 

receptors in smooth muscle cells. A. 

Adebiyi, G. Zhao, D. Narayanan, C.M. Thomas, J.P. Bannister 

and J.H. Jaggar. Univ. of Tennessee Hlth. Sci. Ctr., Memphis. 

D183 985.2 K2P-like current in freshly dissociated mouse 

thoracic aorta: the impact on thoracic aorta diameter. R. 

Bychkov, S. Hayoz, Y. Soliman, L. Cubano and H. Maldonado. 

Univ. Central del Caribe, PR and Michigan State Univ. 

D184 985.3 Atomic force microscope studies demonstrate 

increased vascular smooth muscle cell stiffness associated 

with aging. Y. Zhu, Z. Sun, H. Qiu, Z. Li, J. Trzeciakowski, W. 

Hunter, D. Vatner, S. Vatner and G. Meininger. UMDNJ-New 

Jersey Med. Sch., Univ. of Missouri-Columbia and Texas A&M 

Univ. Hlth. Sci. Ctr. 

D185 985.4 Modulation of ATP release in gastrocnemius 

muscle 1A arterioles. H.A. Kluess, A.J. Stone and K.W. 

Evanson. Univ. of Arkansas. 

D186 985.5 Augmented endothelin-1 constriction in 

pudendal arteries from ETB receptor-deficient rats: linking 

hypertension and female sexual dysfunction. K.J. Allahdadi, 

J.L. Hannan, E.I. Boesen and R.C. Webb. Med. Col. of 

Georgia. 

D187 985.6 Monoamine oxidase activity in skeletal muscle 

conduit and resistance vessels. K.W. Evanson, A.J. Stone 

and H.A. Kluess. Univ. of Arkansas. 


D188 985.7 Regulation of voltage-gated calcium channel 

expression by estrogen. J. Dalton, B.K. Joseph, N.J. Rusch 

and B.J.F. Hill. Univ. of Central Arkansas and Univ. of Arkansas 

for Med. Sci. 

D189 985.8 Impact of hypertension and hormonal status 

on relaxation of the pudendal vasculature in aging female rats. 

J.L. Hannan, K.J. Allahdadi, F. Giachini, A. Dorrance and 

R.C. Webb. Med. Col. of Georgia and Michigan State Univ. 

D190 985.9 Ca v 

1.2 N-terminal splice variants regulate 

cerebral artery diameter. J.P. Bannister, C. Thomas, A. Adebiyi, 

X. Cheng, G. Zhao and J.H. Jaggar. Univ. of Tennessee Hlth. 

Sci. Ctr., Memphis. 

D191 985.10 Age- and sex-related changes in purinergic 

metabolism in the skeletal muscle vasculature. A.J. Stone, 

K.W. Evanson and H.A. Kluess. Univ. of Arkansas. 

D192 985.11 Organ culture: effect on fetal and adult cerebral 

arterial contractility. R. Goyal, N. Chu, D. Goyal and L.D. 

Longo. Loma Linda Univ. 

D193 985.12 Smad3 inhibits myocardin expression in the 

initial stage of smooth muscle differentiation. S-Y. Chen, W. 

Xie, X. Long and J.M. Miano. Univ. of Georgia and Univ. of 

Rochester. 

D194 985.13 Second messenger communication and the 

regulation of vascular contractility. C.H. Tran, F. Plane, M. 

Taylor and D. Welsh. Univ. of Calgary, Univ. of Alberta and 

Univ. of South Alabama. 

D195 985.14 Intrinsic circadian oscillation of myosin light 

chain phosphorylation in vascular smooth muscle cells. T. 

Saito, M. Hirano, T. Ide, K. Sunagawa and K. Hirano. Kyushu 

Univ. Grad. Sch. of Med. Sci., Japan. 

D196 985.15 l-Arginine intake improves tolerance to physical 

exercise and vascular reactivity in obese trained rats. A. 

Zanesco, J. Rojas-Moscoso, R. Gómez-Campos, C. Valgas 

da Silva, E.M. Carneiro, E. Antunes and F.B.M. Priviero. 

UNESP, Rio Claro and UNICAMP, Campinas, Brazil. 

D197 985.16 Downrgulation of L-type calcium channels 

increase media thicknes and change smooth muscle phenotype 

in rat resistance arteries in vivo. C. Aalkjær, K. Møller and V. 

Matchkov. Aarhus Univ., Denmark. 

D198 985.17 Endothelin-1 induces smooth muscle cell 

plasticity in small mesenteric arteries. M. Schoorl, E.N. Bakker, 

J. de Vos and E. vanBavel. Acad. Med. Ctr., Amsterdam. 

D199 985.18 Molecular mechanisms of serotonergic 

potentiation of endothelin-1: involvement of the JAK2 and 

p42/44 MAPK pathways. D. Telraja, S. Bhaskaran, Z. Ahmad, 

J. Day and A.K.L. Banes-Berceli. Oakland Univ. 

D200 985.19 Intracellular calcium stores contribute to the 

myogenic response of rat cerebral arteries. R. Tam, P.M. Kerr 

and F. Plane. Univ. of Alberta. 

986. Smooth Muscle Physiology and 

Pharmacology 

Poster 



D201 986.1 Phosphatidylinositol 3,5-bisphosphate 

increases intracellular free Ca 2+ in VSMC and elicits vascular 

contraction. N. Silswal, N.K. Parelkar and J. Andresen. Univ. 

of Missouri-Kansas City Sch. of Med. 

304

tuesday 

D202 986.2 Bisphenol A activates Maxi-K channels in 

coronary smooth muscle. S. Asano and G.M. Dick. West 

Virginia Univ. 

D203 986.3 Hypotensive, hypolipidemic, and vascular 

protective effect of Morus alba L. in rats fed a high-fat diet. Y.J. 

Lee, D.H. Choi, S.M. Hwang, Y.M. Ahn, J.S. Kim, D.G. Kang 

and H.S. Lee. Wonkwang Univ.Republic of Korea and Korea 

Inst. of Oriental Med., Daejeon. 

D204 986.4 Vascular relaxation by ethanol extract of 

Xanthoceras sorbifolia via Akt- and SOCE-eNOS-cGMP 

signaling. S.N. Jin, J.F. Wen, X. Li, D.G. Kang, H.S. Lee and 

K.W. Cho. Taishan Med. Univ., People’s Republic of China and 

Wonkwang Univ. Professional Grad. Sch. of Oriental Med., 


D205 986.5 Alteration of guanylyl cyclase-activated 

vasorelaxation in thoracic aorta from hyperthyroid rats. J.F. 

Wen, S.N. Jin, Y.L. Wang, G.H. Zhou, X.N. Wang and K.W. 

Cho. Taishan Med. Univ., People’s Republic of China. 

D206 986.6 The effect of ethanol on tracheal smooth muscle 

of cat. M. Jakupaj, R.B. Sopi, A. Lajçi, B. Neziri, S. Devaja- 

Kumnova and A. Krasniqi. Fac. of Med., Univ. of Prishtina, 

Kosovo. 

D207 986.7 Improvement of relaxation in type II diabetic 

mice corpus cavernosum by PhTx2-6 toxin from Phoneutria 

nigriventer spider. K.P. Nunes, R.C. Tostes, M.E. de Lima 

and R.C. Webb. Med. Col. of Georgia and Fed. Univ. of Minas 

Gerais, Brazil. 

D208 986.8 MYPT1 structure mediates PKG[alpha] 

phosphorylation. S. Yuen, O. Ogut and F. Brozovich. Mayo 

Clin. 

D209 986.9 Pharmacological block of K Ca 

1.1 channel 

increases the amplitude of nerve-evoked contractions induced 

by electrical field stimulation in human detrusor smooth muscle. 

G.V. Petkov, W.F. Kellett and E.S. Rovner. Univ. of South 

Carolina Col. of Pharm. and Med. Univ. of South Carolina. 

D210 986.10 The effect of electroacupuncture on bladder 

dysfunction caused by streptozotocin-induced diabetes. J-M. 

Liao, T-B. Lin and Y-M. Liou. Sch. of Med., Chung-Shan Med. 

Univ. and Natl. Chung-Hsing Univ., Taiwan. 

D211 986.11 Metformin treatment of angiotensin II 

hypertensive rats decreased electric field stimulation-mediated 

contraction in corpus cavernosum. H. Labazi, B.M. Wynne and 

R.C. Webb. Med. Col. of Georgia. 

D212 986.12 The small GTPase RhoA stimulates the 

contraction of airway smooth muscle by regulating actin 

polymerization rather than myosin light chain phosphorylation. 

W. Zhang and S.J. Gunst. Indiana Univ. Sch. of Med. 

D213 986.13 Heterogeneity in constrictor responses among 

selected inbred mouse strains: influence of Rho-kinase. S.P. 

Didion. Med. Col. of Georgia. 

D214 986.14 Effect of betulinic acid on high glucose-induced 

vascular smooth muscle cells proliferation. J.J. Yoon, Y.J. Lee, 

J.S. Kim, D.G. Kang and H.S. Lee. Professional Grad. Sch. of 

Oriental Med., Republic of Korea and Korea Inst. of Oriental 

Med., Daejeon. 

D215 986.15 Effect of Lophatherum gracile Brongn on the 

mechanism of vasorelaxation in thoracic aorta. H.Y. Kim, X. 

Li, D.G. Kang and H.S. Lee. Wonkwang Univ., Republic of 

Korea. 

D216 986.16 Interaction of fluoxetine and paroxetine with 

muscle nicotinic acetylcholine receptors. J.D. Andersen, D. 

Feuerbach, M.O. Ortells and H. Arias. Midwestern Univ., AZ, 

Novartis Insts. for Biomed. Res., Basel and Fac. of Med. and 

CONICET, Univ. of Morón, Argentina. 

physiology 

987. PGC-1alpha in Health, Exercise and 

Disease 

Poster 



D217 987.1 Endurance exercise and systemic mitochondrial 

rejuvenescence: run for your life! A. Safdar, J.P. Little, B.P. 

Hettinga, G.C. Kujoth, T.A. Prolla and M.A. Tarnopolsky. 

McMaster Univ. and Univ. of Wisconsin-Madison. 

D218 987.2 The role of nuclear respiratory factor-1 in 

regulating GLUT4 expression. E. Mukwevho and E. Ojuka. 

Univ. of Cape Town. 

D219 987.3 Suppression of calcineurin signaling reduces 

PGC-1a expression in a chronic model of muscle atrophy. T.K. 

Roberts, S.K. Donaldson, J.L. Gooch and S.R. Price. Sch. 

of Med. and Sch. of Nursing, Emory Univ. and Atlanta VA Med. 

Ctr. 

D220 987.4 The effects of contractile activity on 

mitochondrial adaptations in PGC-1a-deficient muscle cells. G. 

Uguccioni and D.A. Hood. York Univ., Canada. 

D221 987.5 Increased PDK4 expression via PGC-1a/ 

ERRa-dependent mechanism in mouse skeletal muscle after 

high fat feeding. R. Rinnankoski-Tuikka, S. Torvinen, M.M. 

Silvennoinen, M. Lehti, R. Kivelä and H. Kainulainen. Univ. 

of Jyväskylä and LIKES Res. Ctr. for Sport and Hlth. Sci., 

Jyväskylä, Finland. 

D222 987.6 Muscle-specific disruption of Sirt1 reduces 

mitochondrial function and increases reactive oxygen species 

production. K.J. Menzies and D.A. Hood. York Univ., Canada. 

D223 987.7 Training-induced improvements in aerobic 

capacity can occur independent of PGC-1a in aging human 

skeletal muscle. A. Konopka, P. Reidy, B. Jemiolo, L. 

Kaminsky, T. Trappe, S. Trappe and M. Harber. Ball State 

Univ. 

D224 987.8 Postnatal PGC-1a gene transfer attenuates 

acute injury in mdx mice. J.T. Selsby and D. Gardan-Salmon. 


D225 987.9 Clenbuterol increases PGC1a promoter activity 

via a rapamycin-sensitive mechanism. A. Philp and K. Baar. 

Univ. of California, Davis. 

988. Comparative Biomechanics, 

Cardiovascular Physiology, Muscle 

Physiology and Behavior 

Poster 



D226 988.1 The cellular force-frequency response 

in ventricular myocytes from the varanid lizard, Varanus 

exanthematicus. D.E. Warren, G.L.J. Galli, S.M. Patrick 

and H.A. Shiels. Univ. of Manchester and Univ. of British 

Columbia. 

D227 988.2 Tensorial description of the geometrical 

arrangement of endothelin-1 in response to the changes of 

blood pressure in rat’s aorta. W. Huang and Y.W. Mak. Hong 

Kong Polytech Univ. 

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Physiology 

D228 988.3 Squid branchial hearts: boosting blood pressure 

in the periphery. T.A. Uyeno and D.L. Barbano. Northern 

Arizona Univ. 

D229 988.4 Atmospheric hypoxia increases bone robusticity 

in the American alligator. T. Owerkowicz, F. Andrade, R. Elsey 

and J.W. Hicks. Univ. of California, Irvine, Fullerton Col., CA 

and Louisiana Dept. of Fisheries & Wildlife, Grand Chenier. 

D230 988.5 Cardiac shunting does not constrain aerobic 

capacity of the American alligator. T. Owerkowicz, J. Eme, J. 

Gwalthney, J.M. Blank and J.W. Hicks. Univ. of California, 

Irvine. 

D231 988.6 Cardiovascular plasticity during hypoxic 

incubation of alligator (Alligator mississippiensis). J. Eme, D.A. 

Crossley II and J.W. Hicks. Univ. of California, Irvine and Univ. 

of North Dakota. 

D232 988.7 Evidence of sternal artery vasoconstriction in 

crayfish, Procambarus clarkii but not Pacifastacus leniusculus. 

D.W. Violi, B. McClean and N. Pelaez. Purdue Univ. 

D233 988.8 Regulation of heart rate in zebrafish embryos. 

S. Rieger and J.E. Contreras. UCLA and NINDS, NIH. 

D234 988.9 Characterization of LPA4 and LPA5 in zebrafish. 

M.S-Y. Kao, C-H. Chang and H-Y. Lee. Natl. Taiwan Univ. 

D235 988.10 Effects of hibernation-induced bradycardia on 

cardiac myosin heavy-chain and myocardial mRNA expression 

in grizzly bears. N.D. Barrows, L. Nelson, C. Robbins and B. 

Rourke. California State Univ., Long Beach and Washington 

State Univ. 

D236 988.11 Changing sexes in a complex environment— 

shifts in skeletal myosin isoforms in coastal populations of 

California sheephead fish. J.N. Bartlett, K.M. Loke, K. Young, 

C. Lowe and B.C. Rourke. California State Univ., Long 

Beach. 

D237 988.12 Altered gene expression in the heart after 

acclimation to hypoxia in goldfish: evaluation of candidate 

reference genes for qPCR studies. S. Chan, T.T.T. Ngo and 

J.S. Cameron. Wellesley Col. 

D238 988.13 Endothelial nitric oxide synthase in the 

amphibian, Xenopus tropicalis. J.A. Donald and S. 

Trajanovska. Deakin Univ., Australia. 

D239 988.14 What triggers the aerobic dive limit Patterns of 

muscle oxygen depletion during dives of Emperor penguins. C.L. 

Williams and P.J. Ponganis. Scripps Instn. of Oceanography. 

D240 988.15 Effects of fecundity on grasshopper locomotory 

performance. M.T. Santa Barbara and S.D. Kirkton. Union 

Col., NY. 

D241 988.16 Neural basis of visually evoked head and wing 

movements in dragonflies. N.M. Grome. Union Col., NY. 

989. Muscle Plasticity and Gene Regulation/ 

Expression 

Poster 



D242 989.1 Differentially expressed microRNAs in 

dystrophin-deficient muscle. D. Gardan-Salmon, E.R. Fritz, D. 

Nettleton, J.M. Reecy and J.T. Selsby. Iowa State Univ. 

D243 989.2 Analysis of dystrophic muscle by two 

dimensional differential in-gel electrophoresis. J. Dixon, D. 

Gardan-Salmon, S. Lonergan and J.T. Selsby. Iowa State 

Univ. 


D244 989.3 Enhanced transforming growth factor b 

signaling and fibrogenesis in fetal skeletal muscle of obese 

sheep at late gestation. Y. Huang, X. Yan, M.J. Zhu, S.P. Ford, 

P.W. Nathanielsz and M. Du. Univ. of Wyoming and Univ. of 

Texas Hlth. Sci. Ctr. at San Antonio. 

D245 989.4 Soleus muscle of Down syndrome mice 

exhibits elevated markers of oxidative and nitrosative stress. 

P.M. Cowley and K.C. DeRuisseau. Syracuse Univ. 

D246 989.5 The effects of exercise on skeletal muscle 

GLUT4 expression in patients with type 2 diabetes. S.E. Yeo, 

S.L. McGee, A. Garnham, G. McConell and M. Hargreaves. 

Univ. of Melbourne and Deakin Univ., Australia. 

D247 989.6 Analysis of glucocorticoid regulated gene 

expression and skeletal muscle atrophy in glucocorticoid 

receptor mutant mice. M.L. Watson, L. Baehr, J. van der 

Brandt, H. Reichardt, J. Tuckermann, S. Bodine and J.D. 

Furlow. Univ. of California, Davis, Univ. of Göttingen Med. Sch. 

and Fritz Lipmann Inst., Jena, Germany,. 

D248 989.7 The role of MuRF1 in glucocorticoid-induced 

skeletal muscle atrophy. L.M. Baehr, J.D. Furlow and S.C. 

Bodine. Univ. of California, Davis. 

D249 989.8 IL-6-induced cachexia and muscle IGF-1 

signaling. J.P. White, S. Sato, M.J. Puppa, J.W. Baynes, S.L. 

Welle and J.A. Carson. Univ. of South Carolina and Univ. of 

Rochester. 

D250 989.9 Elevated IL-1RA levels blunt exercise-induced 

increases in Hsp25 and Hsp72 in mouse muscle. K. Huey, 

B. Meador and G. Freund. Drake Univ. and Univ. of Illinois, 

Urbana. 

D251 989.10 Effects of IL-6 receptor inhibition and/or heat 

treatment on the regeneration of injured mouse skeletal muscle. 

R. Fujita, T. Ohira, K. Kami, Y. Oke, S. Nomura, F. Kawano, 

N. Nakai and Y. Ohira. Grad. Sch. of Med. and Grad. Sch. of 

Frontier Biosci., Osaka Univ. 

D252 989.11 Tyrosine phosphorylation regulates mechanical 

stretch-induced activation of protein translation initiation in 

C2C12 myoblasts. N. Nakai, F. Kawano, Y. Oke, S. Nomura, 

T. Ohira, R. Fujita and Y. Ohira. Grad. Sch. of Med. and Grad. 

Sch. of Frontier Biosci., Osaka Univ. 

D253 989.12 Electrical stimulation induces AMPK-mediated 

cell cycle arrest in C2C12 myoblasts. B. Duchene and M.K. 

Connor. York Univ., Canada. 

D254 989.13 Regulation of p53 mRNA by AMP kinase 

activation in C2C12 myoblasts. A. Saleem, M. Shuen and D.A. 

Hood. York Univ., Canada. 

D255 989.14 Regulation of Tfam mRNA stability in skeletal 

muscle fiber types. D.M. D’souza, R.Y.J. Lai and D.A. Hood. 

York Univ., Canada. 

D256 989.15 Deficiency of Bax promotes compensatory 

muscle hypertrophy as induced by denervation of agonists. 

P.M. Siu and S.E. Alway. Hong Kong Polytech Univ. and West 

Virginia Univ. 

D257 989.16 Plantaris muscle capillarity is reduced in 

pulmonary TNFa over-expressing mice. I.M. Olfert, G. Audet, 

M. Malek, K. Tang, E.C. Breen and P.D. Wagner. West Virginia 

Univ. Sch. of Med. and UCSD. 

D258 989.17 Influence of myostatin on skeletal muscle 

plasticity. S. Reisz-Porszasz, A. Abraham, M. Baker, I. 

Kovanecz, J. Porszasz and V.J. Caiozzo. Charles Drew Univ. 

of Med. and Sci., Univ. of California, Irvine and LA BioMed. Res. 

Inst., Torrance. 

306

tuesday 

D259 989.18 Force deficits of human type I, IIa, and IIa/IIx 

muscle fibers following a single in vitro eccentric contraction. 

S.J. Choi and J.J. Widrick. Oregon State Univ. and Harvard 

Med. Sch. and Spaulding Rehab. Hosp. 

D260 989.19 PLA2 activity declines during skeletal myoblast 

differentiation. T.J. Burkholder. Georgia Tech. 

D261 989.20 Intergenic bidirectional promoter of cardiac 

myosin heavy chain genes in rats. J.M. Giger, K.M. Baldwin 

and F. Haddad. Univ. of California, Irvine. 

D262 989.21 Quantification of dynamic mitochondrial 

morphologies in myoblasts. S. Iqbal and D.A. Hood. York 


D263 989.22 Discrepancy between increased mTORC1 

signaling and total muscle protein accretion after leucine 

stimulation. A. Haegens, A.M. Schols, A.L.M. van Essen, 

L.J.C. van Loon and R.C. Langen. Top Inst. Food and Nutr., 

Wageningen and NUTRIM Sch. for Nutr., Toxicol. and Metab., 

Maastricht Univ., Netherlands. 

D264 989.23 Nitric oxide synthase inhibition prevents 

activity-induced NFAT nuclear accumulation and skeletal 

muscle adaptation. K.J.B. Martins, M. St-Louis, R.N. Michel, 

G.K. Murdoch, W.T. Dixon, I.M. MacLean, P. McDonald and 

C.T. Putman. Univ. of Alberta, Concordia Univ., Canada and 

Univ. of Idaho. 

D265 989.24 Post-exercise feeding attenuates proteolytic 

gene expression in human skeletal muscle. M. Harber, A. 

Konopka, B. Jemiolo, T. Trappe, S. Trappe and P. Reidy. Ball 

State Univ. 

D266 989.25 The use of sunset as a non-radioactive method 

for measuring rates of protein synthesis in whole skeletal 

muscles and in single fibers. C.A. Goodman, D.M. Mabrey, J.W. 

Frey, H.C. Lincoln, M.H. Miu, E.K. Schmidt, P. Pierre and T.A. 

Hornberger. Univ. of Wisconsin-Madison and Immunol. Ctr. of 

Marseille-Luminy. 

D267 989.26 Specific force generation and injury 

susceptibility of permeabilized single skeletal muscle fibers 

from myostatin-deficient mice. E. Kayupov, J. Bradley, D.R. 

Claflin and C.L. Mendias. Univ. of Michigan. 

D268 989.27 Scleraxis and fibroblast specific protein-1 

identify fibroblast cells in skeletal muscle tissue. M.V. Shallal- 

Ayzin, J.P. Gumucio, K.I. Bakhurin, C.L. Mendias and S.V. 

Brooks. Univ. of Michigan. 

990. Altitude and Hypoxia 

Poster 



D269 990.1 Hypoxic exercise training affects Ox- 

LDL-stimulated thrombin generation of monocyte-derived 

microparticles. Y-L. Chang and J-S. Wang. Chang Gung Univ., 

Taiwan. 

D270 990.2 Hypoxic exercise training elicits the mobilization 

of hematopoietic progenitor cells and endothelial precursor 

cells into the peripheral blood compartment in healthy men. 

M-Y. Lee and J-S. Wang. Chang Gung Univ., Taiwan. 

D271 990.3 Effects of acute and chronic hypoxia exercise 

on erythrocyte aggregation and binding of fibrinogen to 

erythrocyte under shear flow. S-Y. Chen and J-S. Wang. Chang 

Gung Univ., Taiwan. 

physiology 

D272 990.4 Systemic hypoxia promotes the mobilization 

of senescent CD8 + T lymphocytes into the peripheral blood 

compartment during moderate-intensity exercise. T-P. Weng 

and J-S. Wang. Chang Gung Univ., Taiwan. 

D273 990.5 Hypoxic exercise training improved gardos 

channel-mediated erythrocyte deformability. T-Y. Mao, L-L. 

Fu and J-S. Wang. Natl. Taiwan Sport Univ. and Chang Gung 

Univ., Taiwan. 

D274 990.6 Chronic hypoxia increases insulin-stimulated 

glucose uptake in mouse skeletal muscle. J. Gamboa, M. 

Garcia-Cazarin and F. Andrade. Univ. of Kentucky. 

D275 990.7 Hypoxic exercise responses in lean and 

obese humans. J.K. Limberg, T. Evans, G. Blain, C. Zillner, 

L. Proctor, J. Sebranek and W. Schrage. Univ. of Wisconsin- 

Madison. 

D276 990.8 Evidence that hypoxia-induced pulmonary 

vasoconstriction in humans is primarily a postcapillary event. 

B.J. Taylor, E. Snyder, T. Olson, K. O’Malley and B. Johnson. 

Mayo Clin. and Univ. of Arizona Col. of Pharm. 

D277 990.9 Effect of acclimation to intermittent hypobaric 

hypoxia on NO homeostasis. J.S. Chang, Y.B. Sim, J.H. Lee, 

S.S. Nam, S. Sunoo and I.D. Kong. Yonsei Univ. Wonju Col. of 

Med. and Kyung Hee Univ. Col. of Phys. Educ. and Sports. Sci., 


D278 990.10 Hydration effects on vascular fluid dynamics 

during acute exposure to 3,048 m. J.W. Castellani, S.R. Muza, 

R.W. Kenefick and M.N. Sawka. U.s. Army Res. Inst. of Envrn. 

Med., Natick, MA. 

D279 990.11 Altitude threshold for sleep disturbances 

during exposure to acute hypobaric hypoxia. B.A. Beidleman, 

S.R. Muza, C.S. Fulco, J.E. Jones, J.E. Staab, R. Demes, S. 

Elliott and A. Cymerman. U.S. Army Res. Inst. of Envrn. Med., 

Natick, MA. 

D280 990.12 Increasing intensity of hypoxia augments Fos 

expression in hypothalamic paraventricular nucleus-projecting 

neurons in the nucleus of the tractus solitarius. T.L. King, 

C.M. Heesch, D.D. Kline and E.M. Hasser. Univ. of Missouri- 

Columbia. 

D281 990.13 Variability in pulmonary function changes 

in United States Antarctic Program participants following 

rapid transport to the South Pole. S. Lalande, M.L. Ceridon, 

P.J. Anderson, A.D. Miller, K.C. Beck, K.A. O’Malley, J.B. 

Johnson and B.D. Johnson. Mayo Clin. and Ctrs. for Dis. 

Control and Prevent., Anchorage. 

D282 990.14 Physical activity and the incidence of acute 

mountain sickness in United States Antarctic program 

participants following rapid transport to the South Pole: Antarctic 

study of altitude physiology. M.L. Ceridon, P.J. Anderson, 

A.D. Miller, K.C. Beck, K.A. O’Malley, J.B. Johnson and B.D. 

Johnson. Mayo Clin. and NIOSH, Anchorage. 

D283 990.15 Peripheral chemoreflex sensitivity and 

sympathetic nerve activity are normal in breath hold divers 

during training season. T. Breskovic, V. Ivancev, I. Banic, J. 

Jordan and Z. Dujic. Univ. of Split Sch. of Med., Croatia and 

Hannover Med. Sch., Germany. 

D284 990.16 Monocyte chemoattractant protein-1 released 

from alveolar macrophages mediates the systemic inflammation 

of alveolar hypoxia. J. Chao, P. Donham, J.G. Wood and N.C. 


D285 990.17 Monocyte chemoattractant protein-1 released 

from hypoxic alveolar macrophages activates systemic mast 

cells. P. Donham, J. Chao, Z. Viets, J.G. Wood and N.C. 


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Physiology 

991. Temperature Regulation and Fluid 

Balance 

Poster 



D286 991.1 Clinical measures of heat stroke recovery do 

not reflect tissue injury in a conscious rat model. B.G. Helwig 

and L.R. Leon. U.S. Army Res. Inst. of Envrn. Med., Natick, 

MA. 

D287 991.2 Submaximal exercise increases Fos expression 

in central noradrenergic A1 and A6 nuclei of rats is related to 

heat storage. G.V. Rodovalho and C.C. Coimbra. Fed. Univ. of 

Minas Gerais, Brazil. 

D288 991.3 Integrity of paraventricular nucleus is critical for 

thermoregulation adjustments during exercise. J.B. Guimarães, 

S.P. Wanner and C.C. Coimbra. Fed. Univ. of Minas Gerais, 

Brazil. 

D289 991.4 Effect of heat stress and ergopeptine alkaloids 

on the immune system of rats. D. Kishore, P.A. Eichen, M.R. 

Waldron, T.J. Evans, K.L. Fritsche and D.E. Spiers. Univ. of 

Missouri-Columbia. 

D290 991.5 Low salt intake during pregnancy and lactation 

causes changes in energy metabolism in adult female Wistar 

offspring. K.L. Lopes Jang, L.N.S. Furukawa, M.S. Dolnikoff 

and J.C. Heimann. Univ. of São Paulo. 

D291 991.6 Effects of XS® energy drink on aerobic exercise 

capacity. K.M. Sheehan and L.K. Hartzler. Wright State Univ. 

D292 991.7 Mild dehydration degrades mood and 

symptoms, not cognitive performance in females: a placebocontrolled 

study. L.E. Armstrong, M. Ganio, E. Lee, B. 

McDermott, J. Klau, L. Yamamoto, S. Marzano, R. Lopez, 

D. Casa, L. Jimenez, L. Le Bellego, E. Chevillotte and H.R. 

Lieberman. Univ. of Connecticut , Texas Hlth. Presbyterian 

Hosp.,Danone Res., Palaiseau, France and U.S. Army Res. 

Inst. of Envrn. Med., Natick, MA. 

D293 991.8 Thermoregulatory responses of cattle to 

controlled dehydration during heat challenge. B.A. Scharf, T. 

Evans and D.E. Spiers. Univ. of Missouri-Columbia. 

D294 991.9 Effects of skin temperature on hypohydration 

mediated hemodynamic responses to submaximal exercise. 

R.W. Kenefick, B.R. Ely, S.N. Cheuvront, L.J. Palombo and 

M.N. Sawka. U.S. Army Res. Inst. of Envrn. Med., Natick, MA. 

D295 991.10 High skin temperature accentuates aerobic 

performance degradation when hypohydrated. R.W. Kenefick, 

S.N. Cheuvront, B.R. Ely, L.J. Palombo and M.N. Sawka. 

U.S. Army Res. Inst. of Envrn. Med., Natick, MA. 

D296 991.11 Heat acclimation improves central cardiac 

function and performance variables in cool environments. 

S. Lorenzo, D. Miller, J.R. Halliwill, M.N. Sawka and C.T. 

Minson. Univ. of Oregon and U.S. Army Res. Inst. of Envrn. 

Med., Natick, MA. 

D297 991.12 Heat acclimation induces peripheral 

modifications in cutaneous vascular function in humans. S. 

Lorenzo, M.N. Sawka and C.T. Minson. Univ. of Oregon and 

U.S. Army Res. Inst. of Envrn. Med., Natick, MA. 

D298 991.13 Effect of passive heating for 14 days on 

thermoregulatory responses and subjective thermal sensation 

in humans. M. Sato, D. Kanikowska, Y. Shimizu, Y. Inukai, 

N. Nishimura, S. Iwase and J. Sugenoya. Aichi Med. Univ., 

Japan. 


D299 991.14 Evaluation of bioimpedance spectroscopy for 

determination of body fluid compartment volumes in rats. L. 

Hu, T. Maslanik, M. Zerebeckyj and C.F. Plato. Gilead Sci. 

Inc., Westminster, CO. 

D300 991.15 Ventilatory changes after active heat 

acclimation for multiday ultramarathon races in the Sahara 

Desert. S.D. Serna, M.E. Clegg and M.D. White. Simon Fraser 


D301 991.16 Influence of hypercapnia and skin temperature 

on pulmonary ventilation in hyperthermic humans. J.G. Greiner, 

M.L. Walsh and M.D. White. Simon Fraser Univ., Canada. 

D302 991.17 Peripheral microvascular responses to 

norepinephrine in women with orthostatic intolerance. M.M. 

Wenner, H.S. Taylor and N.S. Stachenfeld. John B. Pierce 

Lab. and Yale Univ. Sch. of Med. 

D303 991.18 Changes in central venous pressure during 

heat stress as a possible predictor of compromised blood 

pressure control during simulated hemorrhage. M.S. Ganio, 

R.M. Brothers, J.E. Wingo, D.M. Keller and C.G. Crandall. 

Texas Hlth. Presbyterian Hosp., Dallas and Univ. of Texas 

Southwestern Med. Ctr. 

D304 991.19 Acute volume infusion preserves left ventricular 

end diastolic volume during combined heat and simulated 

hemorrhage. R.M. Brothers, T. Wilson, M. Dalsgaard, M. 

Bundgaard-Nielsen, R. Pecini, N.H. Secher and C.G. 

Crandall. IEEM, Dallas, Univ. of Texas Southwestern Med. 

Ctr., Ohio Univ. Col. of Osteo. Med. and Rigshosp., Univ. of 

Copenhagen. 

D305 991.20 Global diastolic function is preserved during 

passive heat stress due to augmented left ventricular untwisting. 

M.D. Nelson, M.J. Haykowsky, S.R. Petersen, D.S. DeLorey, 

J. Cheng-Baron and R.B. Thompson. Univ. of Alberta. 

D306 991.21 TRPV-1 channels contribute to local and reflex 

cutaneous vasodilation in humans. B.J. Wong, S.M. Fieger 

and C.J. Ade. Kansas State Univ. 

D307 991.22 Differential vasodilatory responses to local 

thermal stimuli in facial, glabrous and hairy skin. T.E. Wilson, 

L. Ramos, C. Tomc, M.A. Simpson, C. Simpson and D. 

Sammons. Ohio Univ. Col. of Osteo. Med. 

D308 991.23 Impact of sex hormones on cutaneous 

neurovascular responses in humans. V.E. Brunt, J.A. Miner, 

E.R. Martini, M.M. Smith, P.F. Kaplan and C.T. Minson. Univ. 

of Oregon and Oregon Hlth. & Sci. Univ. 

D309 991.24 Effect of stratum corneum hydration on the 

composition of sweat collected by an occlusive sweat patch. 

G.W. Mack and P. Taylor. Brigham Young Univ. 

D310 991.25 Impaired sweating in multiple sclerosis leads to 

increased reliance on skin blood flow for heat dissipation. S.L. 

Davis, M.A. Korkmas, C.G. Crandall and E.M. Frohman. Univ. 

of Texas Southwestern Med. Ctr. and Texas Hlth. Presbyterian 

Hosp. Dallas. 

D311 991.26 Localized tyrosine or tetrahydrobiopterin 

supplementation augments vasoconstriction in aged human 

skin. J.A. Lang, L.A. Holowatz and W.L. Kenney. Penn State. 

D312 991.27 Is there a delay in the activation of nonnoradrenergic 

vasoconstriction during cold exposure in human 

skin G.H. Simmons, S.M. Fieger, C.T. Minson and J.R. 

Halliwill. Univ. of Oregon. 

D313 991.28 Influence of oral vitamin C on vasoconstrictor 

response to local cooling in human skin. F. Yamazaki, K. 

Takahara and R. Sone. Univ. of Occup. and Envrn. Hlth. and 

Univ. of Yamaguchi, Japan. 

308

tuesday 

D314 991.29 Altered water vapor and evaporation during 

exercise in a cold weather garment layering system. B.W. 

Wilkins, M.L. Kvernmo and L.G. Myhre. Nike Sport Res. 

Lab.,Beaverton, OR. 

D315 991.30 Investigation of sportswear properties in 

athletes performance in hot condition. L. Yao and Y. Li. Hong 

Kong Polytech Univ. 

D316 991.31 Impaired coronary artery vasodilation during 

skin surface cooling in healthy older adults. Z. Gao, T.E. Wilson, 

K.L. Hess and K.D. Monahan. Penn State Col. of Med. and 

Ohio Univ. Col. of Osteopath. Med. 

992. CNS Regulation of Body Temperature 

Poster 



D317 992.1 Central efferent pathways mediating shivering 

thermogenesis. K. Nakamura and S.F. Morrison. Kyoto Univ. 

and Oregon Hlth. & Sci. Univ., Beaverton. 

D318 992.2 Treatment with an adenosine receptor 

antagonist completely blocks fasting-induced torpor in mice. 

B.W. Iliff and S.J. Swoap. Williams Col. 

D319 992.3 Contribution of the paraventricular nucleus in 

the heat stress-induced cardiovascular adjustments. L.H.R. 

Leite, H. Zheng, C.C. Coimbra and K.P. Patel. Fed. Univ. of 

Minas Gerais, Brazil and Univ. of Nebraska Med. Ctr. 

D320 992.4 Electroencephalographic effects of RVMM 

inhibition in free-behaving rats. D. Tupone, M. Cerri, M. Luppi, 

D. Martelli, M. Mastrotto and R. Amici. Univ. of Bologna. 

D321 992.5 The application of gold nanoprobes using an in 

vitro tissue slice preparation for the phenotypical classification, 

connectivity assessment, and electrophysiological recording of 

hypothalamic thermoregulatory neurons. K.C. Mendoza, V.D. 

McLane, S. Kim and J.D. Griffin. Col. of William and Mary. 

D322 992.6 Disinhibition of neurons in paraventricular 

hypothalamic nucleus inhibits cold-evoked shivering. S.F. 

Morrison. Oregon Hlth. & Sci. Univ.,, Beaverton. 

D323 992.7 Push-pull thermoregulatory control by raphéprojecting 

preoptic neurons M. Tanaka, M.J. McKinley and 

R.M. McAllen. Howard Florey Inst., Parkville, Australia. 

993. Neuroendocrinology and 

Neuroimmunology 

Poster 



D324 993.1 Class I and II anabolic steroids produce 

opposite hedonic and rewarding effects in pubertal and adult 

mice. P. Brito, A. Huertas, B. Villafañe, K. Ramos, D. Rosa 

and J. Barreto. Univ. del Este, PR, Univ. of Puerto Rico and 

Univ. of Puerto Rico Sch. of Med. 

D325 993.2 Intrauterine maternal food restriction programs 

neuroendocrine changes that shorten the reproductive lifespan 

of female offspring. E.M. Keen-Rhinehart, M. Desai and M.G. 

Ross. Susquehanna Univ. and David Geffen Sch. of Med. at 

UCLA. 

physiology 

D326 993.3 The blockade of oxytocinergic receptors in the 

CeA modify VP plasma levels and mRNA expression induced 

by hypertonic BVE in the rat. L.O. Margatho, C.F. Elias, L.L.K. 

Elias and J. Antunes-Rodrigues. Univ. of São Paulo, Ribeirão 

Preto and Univ. of Texas Southwestern Med. Ctr. 

D327 993.4 Neurochemical alterations of sensory nerve in 

bone of osteoporosis-induced female rats. S. Poonyachoti, C. 

Deachapunya, P. Ueasilamongkol, N. Chareonpundhu and 

N. Krishnamra. Chulalongkorn Univ., Srinakharinwirot Univ. 

and Mahidol Univ., Thailand. 

D328 993.5 a1-Adrenergic receptor subtypes: involvement 

in regulation of supraoptic nucleus vasopressin and oxytocin 

neurons. C.D. Sladek, W. Stevens and Z. Song. Univ. of 

Colorado Denver Sch. of Med., Aurora. 

D329 993.6 Oxidative stress and androgens have a 

synergistic effect on dopamine cell viability. R.L. Cunningham 

and M. Singh. Univ. of North Texas Hlth. Sci. Ctr. 

D330 993.7 Hormetic effects of serum deprivation on 

androgen regulation of dopamine cell viability. R.L. Cunningham 

and M. Singh. Univ. of North Texas Hlth. Sci. Ctr. 

D331 993.8 Effects of Ganoderma lucidum spores on 

changes of both caspase-8 and nestin in epilepsy rats. S-Q. 

Wang, Y-M. Kang, X-J. Li, L. Liu, J-X. Liu, X-L. Zhao, F-F. 

Wang and L. Zhao. Jiamusi Univ. and Shanxi Med. Univ., 

People’s Republic of China and LSU. 

D332 993.9 Effects of Ganoderma lucidu spores powder 

on expression of NCAM-1 and NCAM-L1 in hippocampus of 

rats with epilepsy. S-Q. Wang, Y-M. Kang, Z-C. Qi, X-R. Ma, 

Y-F. Liang, D-G. Li and B. Zhang. Jiamusi Univ., Shanxi Med. 

Univ., People’s Republic of China and LSU. 

D333 993.10 Effects of Ganoderma lucidu spores on 

expression of PSA-NCAM and hippocampus mossy fiber 

sprouting in pentylenetetrazol-induced epileptic rats. X-J. Li, 

S-Q. Wang, S-L. Zhang and Y-M. Kang. Rehab. Med. Col. and 

Basic Med. Col., Jiamusi Univ. and Shanxi Med. Univ., People’s 


994. CNS Regulation of Food Intake and 

Body Weight 

Poster 



D334 994.1 Electrical stimulation of the subfornical organ 

induces feeding and drinking in satiated rats. P.M. Smith and 

A.V. Ferguson. Queen’s Univ., Canada. 

D335 994.2 Nesfatin-1 influences the excitability of neurons 

in the nucleus of the solitary tract. A.V. Mimee, T.D. Hoyda and 

A.V. Ferguson. Queen’s Univ., Canada. 

D336 994.3 Gastric infusion of nutritional supplement in 

fasted rats increases splanchnic sympathetic nerve activity 

and activates RVLM-projecting neurons of the paraventricular 

hypothalamus. A.L. Sharpe, M.A. Andrade, M. Herrera- 

Rosales, A.S. Calderon and G.M. Toney. Univ. of Texas Hlth. 

Sci. Ctr. at San Antonio. 

D337 994.4 Simultaneous introduction of a novel high fat 

diet and wheel running induces anorexia. E. Scarpace, M. 

Matheny, K-Y. Cheng and B. Erdos. Univ. of Florida. 

D338 994.5 Mechanisms of neuropeptide AF-induced 

anorexia in chickens. B. Newmyer, P. Siegel and M. Cline. 

Radford Univ. and VPI and State Univ. 

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Physiology 

D339 994.6 Differential effects of monoamine reuptake 

inhibitors on food intake and energy expenditure in a mouse 

model of diet-induced obesity. W.J. Martin, Y.Y. Kim, G. 

Obedencio, P.R. Tsuruda and F. Shen. Theravance, South 

San Francisco and UCSD. 

D340 994.7 Cannabinoid action on cholecystokininresponsive 

nodose ganglion cells. G.L. Edwards, A. Page, M.D. 

Harris, S. Hammond and K.G. Freeman. Univ. of Georgia. 

D341 994.8 Differences in POMC and TRPV 3 expression 

in the brainstem of obese-prone and obese-resistant rats. J. 

Hu, J. Choo and S-X. Ma. David Geffen Sch. of Med. at UCLA 

and Harbor-UCLA Med. Ctr. 

995. Insulin, Glucagon and Other 

Pancreatic Hormones 

Poster 



D342 995.1 Genotypic variation in DPP4 modulates 

sensitivity to pharmacologic DPPIV inhibition. A.V. Woodard- 

Grice, A. Marney, S. Kunchakarra and N.J. Brown. Vanderbilt 

Univ. 

D343 995.2 Loss of interleukin-6 blunts glucagon secretion 

during hypoglycemia. V.U. Chukwuma, R.T. Morris, K.X. 

Mulligan and O.P. McGuinness. Vanderbilt Univ. 

D344 995.3 Sitagliptin lowers glucagon and improves 

glucose tolerance in prediabetic obese SHROB rats. P. 

Ernsberger, B. Chen, D. Hou, L. Escobedo, A. Moore, M.S. 

Koletsky and R.J. Koletsky. Case Western Reserve Univ. 

D345 995.4 Glucagon activates the AMP-activated protein 

kinase/acetyl-CoA carboxylase pathway in adipocytes. I-C. 

Peng, Z. Chen, P-H. Hsu, M-I. Su, M-D. Tsai and J.Y-J. Shyy. 

Univ. of California, Riverside and Inst. of Biol. Chem., Acad. 

Sinica, Taipei. 

996. Obesity and Satiety 

Poster 



D346 996.1 Humor-associated laughter affects appetite 

hormones. L. Berk, M. Prowse, G. Bains, J. Batt, J. Petrofsky, 

N. Daher, H. Danner, L. Ludeman, M. Lahman, S. Tan and 

D. Berk. Loma Linda Univ., Azusa Pacific Univ. and OakCrest 

Res. Inst., Loma Linda. 

D347 996.2 Inhibition of soluble epoxide hydrolase reduces 

food intake and increases metabolic rate in mice fed high fathigh 

fructose diet. J.M. do Carmo, A.A. Silva, J. Morgan and 

J.E. Hall. Univ. of Mississippi Med Ctr. 

D348 996.3 Visfatin-induced lipid raft redox signaling 

platforms and hyperpermeability in glomerular endothelial 

cells. K.M. Boini, C. Zhang, M. Xia and P-L. Li. Virginia 

Commonwealth Univ. 

D349 996.4 Activation of inflammasomes by visfatin in 

mouse endothelial cells. M. Xia, J. Hu, Z. Wang, C. Zhang, N. 

Li and P-L. Li. Virginia Commonwealth Univ. 

D350 996.5 Effects of chronic fructose feeding on leptin 

sensitivity and obesity in mice. E.J. Tillman and S.J. Swoap. 

Williams Col. 


997. Protein, Amino Acid and Carbohydrate 

Metabolism 

Poster 



D351 997.1 Skeletal muscle protein balance in mTOR 

heterozygous mice in response to endotoxin and leucine. C.H. 

Lang, R.A. Frost, S.K. Bronson, C.J. Lynch and T.C. Vary. 

Penn State Col. of Med. 

D352 997.2 PRAS40 regulates protein synthesis, cell cycle, 

proliferation and myogenic differentiation in C2C12 myocytes. 

A.A. Kazi, L. Hong-Brown and C.H. Lang. Penn State Col. of 

Med. 

D353 997.3 Long-chain n-3 polyunsaturated fatty acid 

supplementation improves the muscle protein anabolic 

response to hyperaminoacidemia-hyperinsulinemia in healthy 

older adults. G.I. Smith, D.N. Reeds, B.S. Mohammed and B. 

Mittendorfer. Washington Univ. in St. Louis. 

D354 997.4 Role of PPARa in the regulation of glutathione 

metabolism. N. Guelzim, J-F. Huneau, D. Tomé and D. 

Hermier. INRA, Paris and AgroParisTech. 

D355 997.5 Angiotensin II increases JNK and IRS-1ser307 

activity via NAD(P)H and inhibits insulin signaling in rats with 

insulin resistance induced by low salt diet. M.S. Coelho, H.B. 

Negri, D.N. Ferreira, I.B. Oliveira, A.E. Hirata, D.E. Casarini, 

P.O. Prada, M.S. Dolnikoff, M.J.A. Saad and J.C. Heimann. 

Univ. of São Paulo Sch. of Med., Fed. Univ. of São Paulo aFed. 

Univ. of São Paulo and State Univ. of Campinas, Brazil. 

D356 997.6 D2O to determine muscle protein synthesis 

rates in response to postexercise nutrition in adults. M. 

Robinson, S. Turner, M. Hellerstein and B. Miller. Colorado 

State Univ., KineMed Inc., Emeryville, CA. 

D357 997.7 Intramuscular testosterone and trenbolone 

enanthate elevates hemoglobin concentrations. S.C. McCoy, 

J.F. Yarrow, C.F. Conover, J.A. Lipinska, C. Santillana and 

S.E. Borst. VA Med. Ctr. and Univ. of Florida. 

D358 997.8 Advancing age enhances AKT activity and 

expression in skeletal muscle without suppressing contractile 

protein degradation and atrogin-1 expression. E. Merrell, A. 

Brown, M. DiSanto-Rose and T.H. Reynolds. Skidmore Col. 

D359 997.9 Oxidative stress leads to a decline in 

mitochondrial capacity in aged fast-twitch, but not slow-twitch 

mouse muscle. D.J. Marcinek, J. Villarin and S. Kruse. Univ. 

of Washington. 

D360 997.10 Skeletal muscle protein synthesis and 

mTORC1 signaling following resistance exercise in young and 

older men and women. C.S. Fry, M.J. Drummond, E.L. Glynn, 

J.M. Dickinson, D.M. Gundermann, K.L. Timmerman, S. 

Dhanani, E. Volpi and B.B. Rasmussen. Univ. of Texas Med. 

Branch. 

D361 997.11 Aging is associated with a dysregulated human 

skeletal muscle microRNA-499 and -208b expression following 

resistance exercise. M.J. Drummond, C.S. Fry, E.L. Glynn, 

K.L. Timmerman, E. Volpi and B.B. Rasmussen. Univ. of 

Texas Med. Branch. 

D362 997.12 Changes in oxidative modifications of skeletal 

muscle proteins in old rats fed a high fat diet. H. Murakami, C. 

Guillet, N. Tardif, J. Salles, Y. Boirie and S. Walrand. INRA, 

Clermont-Ferrand, France. 

310

tuesday 

D363 997.13 Impact of activated T cells on rat skeletal 

muscle satellite cell function. B.R. Dumke and S.J. Lees. 

Colorado State Univ. 

D364 997.14 Age-related anabolic resistance after 

endurance type exercise in humans. W. Durham, S. 

Casperson, E.L. Dillon, M.A. Keske, D. Paddon-Jones, A. 

Sanford, K.M. Lakshman, R.C. Hickner, C. Hong, J. Grady 

and M. Sheffield-Moore. Univ. of Texas Med. Branch, Menzies 

Res. Inst., Hobart, Australia and East Carolina Univ. 

D365 997.15 Differential gene expression of Toll-like 

receptors in response to muscle injury in young and old 

muscles. S. Machida, Y. Kunisawa and J. Peake. Sch. of 

Phys. Educ., Tokai Univ., Japan and Sch. of Human Movement 

Studies, Univ. of Queensland. 

D366 997.16 Myostatin attenuates hyperplasia and is 

important for muscle remodeling during compensatory growth. 

M. St-Louis, M. Solecki and R.N. Michel. Concordia Univ., 

Canada. 

998. Epithelial Barrier Function in 

Inflammatory Bowel Disease 

Poster 



D367 998.1 Tricellulin in Crohn’s disease and ulcerative 

colitis. S.M. Krug, C. Bojarski, A. Fromm, J.D. Schulzke and 

M. Fromm. Charité, Berlin. 

D368 998.2 Disruption of the tight junction complex by the 

cins-mutation of NOD2. L.S. Poritz and L.R. Harris III. Milton 

S. Hershey Med. Ctr. 

D369 998.3 Signal transducer and activator of transcription 

5 in enterocytes promotes intestinal mucosal wound healing by 

regulation of epithelial tight junction assembly. X. Han and S. 

Gilbert. Cincinnati Children’s Hosp. Med. Ctr. 

D370 998.4 Expression of the Crohn’s disease candidate 

gene, PTPN2, is upregulated in active Crohn’s disease. M. 

Scharl, A. Weber, M. Hausmann, G. Rogler and D.F. McCole. 

Univ. Hosp. Zurich and UCSD. 

999. Epithelial Cell Polarity and Barrier 

Function 

Poster 



D371 999.1 Interplay between septin 2 and aquaporin 5 as 

a novel mechanism to modulate epithelial barrier function by 

regulation of microtubular stability. V. Sidhaye, E. Chau and 

L.S. King. Johns Hopkins Univ. 

D372 999.2 Cholera toxin enhances ENaC-mediated 

sodium absorption across cultured human mammary epithelial 

cells. Q. Wang, L-H. Wang and B.D. Schultz. Kansas State 

Univ. 

D373 999.3 Claudin-4 is required for EGFR-mediated 

alveolar epithelial migration. D. Rokkam, G. Ho and J.A. Frank. 

UCSF/NCIRE-The Veterans Hlth. Res. Inst. 

physiology 

D374 999.4 Impaired expression of prostaglandin E 2 

synthesis and degradation enzymes in urothelial cells from 

patients with interstitial cystitis. J. McHowat, A. Rickard and J. 

Marentette. Saint Louis Univ. 

1000. Liver Physiology and Pathophysiology 

Poster 



D375 1000.1 Suppression of extracellular signal-regulated 

kinase-1/2 causes fat accumulation in hepatocytes: a potential 

mechanism in alcoholic fatty liver disease. Z. Wang, T. Yao and 

Z. Song. Uni. of Illinois at Chicago. 

D376 1000.2 Leptin acts as a metabolic regulator of Angptl6 

expression. N.H. Kim, M.J. Kim, D.S. Kim and I.D. Kong. Col. 

of Nursing, Keimyung Univ. and Wonju Col. of Med., Yonsei 


D377 1000.3 Histamine and specific histamine receptors 

increase normal cholangiocyte growth via differential 

mechanisms. H. Francis, E. Gaudio, Y. Ueno, J. Venter, 

P. Onori, S. DeMorrow and G. Alpini. Scott & White/Texas 

A&M Hlth. Sci. Ctr. Col. of Med., Univ. of Rome, “La Sapienza”, 

Tohoku Univ. Sch. of Med., Univ. of L’Aquila, Italy and Central 

Texas Veterans Hlth. Care Syst., Temple. 

D378 1000.4 Stimulation of the hepatic Toll-like receptor 

signaling pathway after induction of equine laminitis using 

gastrointestinal models. A.M. Stokes, M. McGeachy, K. 

Carlisle, M.L. Keowen and F. Garza. Univ. of Hawaii and 

LSU. 

D379 1000.5 Mechanical stretch stimulates cholangiocyte 

proliferation and profibrotic gene expression. M.K. Munshi, C. 

Wise, F. Yang, D.E. Dostal and S.S. Glaser. Texas A&M Hlth. 

Sci. Ctr., Temple. 

D380 1000.6 Synergistic effect of hydrogen sulfide and 

endotoxin on caveolin-1 expression in liver sinusoidal 

endothelial cells. S. Larion, C. Culberson, E. Norris and M.G. 

Clemens. Univ. of North Carolina at Charlotte. 

D381 1000.7 Biophysical assessment of AQP9 as real 

membrane pathway in hepatocyte glycerol uptake. G. Calamita, 

E. Fanelli, M. Svelto and P. Gena. Univ. of Bari, Italy. 

D382 1000.8 Arimoclomol® enhances hepatic stress protein 

accumulation after an acute bout of heat stress. S.A. Bloomer, 

I. Cernak, J.L. Haak and K.C. Kregel. Univ. of Iowa and Johns 

Hopkins Univ. Applied Phys. Lab., Laurel, MD. 

D383 1000.9 Effects of polysaccharide of Polygonum 

multiflorum Thunb on mtDNA deletion mutation and the level of 

CO I and ATPase 6 mRNA expression in aging model rats’ liver. 

X-D. Wei, Y-M. Kang, Q. Ou, Z. Wang, Z-C. Qi, S-Q. Wang, Q-L. 

Ji and D-G. Li. Jiamusi Univ. and Shanxi Med. Univ., People’s 


D384 1000.10 Metabolomic profiling of the liver bearing 

human colon cancer metastasis in superimmunodeficient NOG 

mice. M. Ohmura, K. Handa, C. Nishime, T. Mizushima, K. 

Kawai, T. Hishiki, T. Yamamoto, M. Wakui, H. Suemizu, M. 

Nakamura and M. Suematsu. Keio Univ. Sch. of Med., CIEA, 

Kanagawa and Tokai Univ. Sch. of Med., Japan. 

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Physiology 

1001. Oxidative Stress Biology 

Poster 



D385 1001.1 Upregulation of heme oxygenase-1 through 

activation of Nrf2 by the phytochemicals in Protandim. D. 

Reuland, J. McCord and K. Hamilton. Colorado State Univ. 

and Univ. of Colorado Denver, Aurora. 

D386 1001.2 Modification of specific amino acid side chains 

during hydroxyl radical-dependent bovine serum albumin 

oxidation. J.F. Turrens, A. Mott, L.F. Pannell and J.C. Ruiz. 

Univ. of South Alabama, Col. of St. Scholastica, MI, Mitchell 

Cancer Inst., Mobile and Univ. of Texas Southwestern Med. 

Ctr. 

D387 1001.3 KGF induction of human peroxiredoxin 6 gene 

expression is mediated by the transcription factor Nrf2. S.I. 

Feinstein, I. Chowdhury, M. Christofidou-Solomidou and 

A.B. Fisher. Univ. of Pennsylvania. 

D388 1001.4 Endothelial cells from peroxiredoxin 6 (Prdx6) 

null mice exhibit increased sensitivity to oxidative stress and 

can be used in rescue experiments with wild type and mutant 

Prdx6 expression vectors. Y-C. Lien, C. Dodia, L. Gao, S.I. 

Feinstein and A.B. Fisher. Univ. of Pennsylvania Sch. of 

Med. 

D389 1001.5 PPARg ligands inhibit hyperglycemia-induced 

endothelial Nox-4 expression and oxidative stress. C.R. 

Williams, G. DeShazer, T. Murphy and C.M. Hart. Emory 

Univ. and Atlanta VA Med. Ctr. 

D390 1001.6 Enhanced oxidative burst activity in 

macrophages from obese African American women with 

metabolic syndrome. M. Colden. Morehouse Sch. of Med. 

D391 1001.7 Vitamin E effects on oxidative damage and cell 

morphology in age-treated SH-SY5Y cells. R. Pazdro and J.R. 

Burgess. Purdue Univ. 

D392 1001.8 Retinoic acid-induced neuroblastoma 

differentiation is dependent from NOX activation. M. Nitti, A. 

Furfaro, C. Cevasco, E. Balbis, N. Traverso, U.M. Marinari, 

M.A. Pronzato and C. Domenicotti. Univ. of Genoa. 

D393 1001.9 Regulation of NADPH oxidase mediated 

oxidative stress in macrophages. L.K. Sarna, N. Wu, Y.L. Siow, 

G. Pierce and K. O. Univ. of Manitoba and St. Boniface Hosp. 

Res. Ctr., Winnipeg. 

D394 1001.10 N-acetylcysteine attenuates ventilator-induced 

diaphragm dysfunction in rats. A. Agten, K. Maes, A.J. 

Smuder, S.K. Powers, M. Decramer and G. Gayan-Ramirez. 

KULeuven, Belgium and Univ. of Florida. 

D395 1001.11 Alteration in skeletal muscle antioxidant 

defense gene expression profile following multiple exposures 

to hyperthermia. S. Sanders, K.L. Flann, M. Yamazaki, L.H. 

Baumgard and R.P. Rhoads. Univ. of Arizona and Iowa State 

Univ. 

D396 1001.12 Decreased aconitase and cytochrome c 

oxidase activity in skeletal muscle of ATM-deficient mice. T.M. 

McDonald, A.Y. Patel and J.S. Fisher. Saint Louis Univ. 

D397 1001.13 Oxygen-induced superoxide production in 

solitary complex neurons in rat medullary slices. J.B. Dean, 

C.S. Landon and D.P. D’Agostino. Univ. of South Florida. 

D398 1001.14 Effect of bosentan on reductive stress-induced 

endothelin-1/eNOS dysfunction in cardiomyocytes. G.D. 

Khanderao, C.J. Davidson, S. Varadharaj, I.J. Benjamin and 

R. Namakkal Soorappan. Univ. of Utah and Ohio State Univ. 


D399 1001.15 Fenofibrate reduces mitochondrial oxidative 

stress and alters membrane composition in the hypertrophied rat 

heart. C.H. Le, C.M. Mulligan, M.A. Routh, T.R. Sterrenberg, 

G.J. Bouma and A.J. Chicco. Colorado State Univ. 

D400 1001.16 Downregulation of MnSOD via Sirt1/FoxO3a 

complex increase oxidative stress with cardiac overexpression 

of type 5 adenylyl cyclase. L. Lai, L. Yan, C-L. Hu, S. Gao, K. 

Iwatsubo, Y. Ishikawa, J. Sadoshima, S.F. Vatner and D.E. 

Vatner. UMDNJ-New Jersey Med. Sch. 

D401 1001.17 Deficiency in gp91phox subunit of NADPH 

oxidase protects against oxidative stress and cardiac 

dysfunction in iron-overloaded mice. C.F. Spurney, J.H. 

Kramer, M. Iantorno, I-T. Mak, J.J. Chmielinska and W.B. 

Weglicki. Children’s Natl. Med. Ctr. and George Washington 

Univ. 

D402 1001.18 Near-infrared LEDd photobiomodulation 

attenuates hypoglycemia-induced cardiotoxicity in a rodent 

model of diabetes mellitus. S. Gopalakrishnan, R. Wilson, J. 

Rakita, S. Antoniewski, B. Abroe, A. Snyder and J. Eells. 

Univ. of Wisconsin-Milwaukee and Med. Col. of Wisconsin. 

D403 

1001.19 Application of in vitro methods for studying 

oxidant stress in lung epithelium of multiple species. S.R. 

Murphy, J.K. Chan, P.C. Edwards and L.S. Van Winkle. Univ. 

of California, Davis. 

D404 

1001.20 Caenorhabditis elegans grown on Mn(II)- 

enriched diet have reduced levels of reactive oxygen species 

in vivo. K. Rakariyatham, A.P. Villarreal Ponce, K. Trinh, C. 

Bach and C. Srinivasan. California State Univ., Fullerton. 

D405 

1001.21 Oxidative metabolism studies on thermal 

regulation-protective mechanism against free radical in 

zebrafish brain. Y-C. Tseng, R--D. Chen and P-P. Hwang. Inst. 

of Cellular and Organismic Biol., Taipei. 

D406 

1001.22 The effects of allopurinol, uric acid sodium 

salt, and inosine on plasma uric acid and xanthine oxidase 

activity in broilers. T.L. Settle, M. Carro, E. Falkenstein and H. 

Klandorf. West Virginia Univ. and Univ. of Leon, Spain. 

1002. Epithelial Transporters 

Poster 



D407 1002.1 Electron microscopy and three-dimensional 

reconstruction of full-length anion exchanger 1. A. Pushkin, I. 

Atanasov, N. Magilnick, K. Tsirulnikov, P. Ge, Z.H. Zhou and 

I. Kurtz. UCLA. 

D408 1002.2 Large-scale identification of phosphorylation 

sites in renal cortical transporters. M. Feric, J.D. Hoffert, T. 

Pisitkun and M.A. Knepper. NHLBI, NIH. 

D409 1002.3 Mineralocorticoids stimulate the activity and 

expression of renal H,K-ATPases. M.M. Greenlee, I.J. Lynch, 

M.L. Gumz, B.D. Cain and C.S. Wingo. Univ. of Florida and 

North Florida/South Georgia VA Med. Ctr. 

D410 1002.4 Vasopressin-mediated signaling in the distal 

convoluted tubule regulates phosphorylation of the thiazidesensitive 

Na + -Cl - cotransporter at two conserved threonine 

residues. N.B. Pedersen, M.V. Hofmeister, J. Nielsen and 

R.A. Fenton. Fac. of Hlth. Sci., Aarhus Univ., Denmark. 

D411 1002.5 The circadian clock protein period 1: a 

candidate master regulator of renal gene expression. M.L. 

Gumz, I.J. Lynch, M.M. Greenlee, B.D. Cain and C.S. Wingo. 

Univ. of Florida and VA Med. Ctr. 

312

tuesday 

D412 1002.6 Dynamic imaging of single microvilli in 

opossum kidney cells. L. Lanzano, P. Fwu, H. Giral, M. Levi 

and E. Gratton. Univ. of California, Irvine and Univ. of Colorado 

Denver, Aurora. 

D413 1002.7 Channel inhibitory region within the STAS 

domain of human SLC26a9. A. Chen and M.F. Romero. Mayo 

Clin. 

D414 1002.8 Genistein’s mechanism(s) of action on intestinal 

chloride secretion in mice. S. Sears, R. Skinner, L. Batia and 

L. Al-Nakkash. Arizona Col. of Osteo. Med., Midwestern Univ. 

D415 1002.9 Prolactin stimulates K + secretion in isolated 

rat distal colon. C. Deachapunya, S. Poonyachoti and N. 

Krishnamra. Srinakharinwirot Univ., Chulalongkorn Univ. and 

Mahidol Univ., Thailand. 

D416 1002.10 Actin cytoskeleton remodeling by RhoA and 

ROCKII regulates vacuolar H + -ATPase (V-ATPase) recycling 

in epididymal clear cells. W.W.C. Shum, N. Da Silva, C. 

Belleannee, M. Ljubojevic, E. Hill, D. Brown and S. Breton. 

Massachusetts Gen. Hosp., Harvard Med. Sch. 

D417 1002.11 Role of AMPK and PKA in the trafficking of 

V-ATPase in kidney intercalated cells. N.M. Pastor-Soler, F. 

Gong, R. Alzamora, C. Smolak, R. Thali, H. Li, D. Neumann 

and K.R. Hallows. Univ. of Pittsburgh and ETH Zurich. 

D418 1002.12 Insulin increases the activity of NCC through a 

PI3K-dependent mechanism. J.P. Arroyo, N. Vazquez and G. 

Gamba. Natl. Autonomous Univ. of Mexico. 

D419 

1002.13 Selectivity of PKC isoforms in the regulation 

of Na + -K + -2Cl - cotransporter in secretory epithelia. J. Tang, P. 

Bouyer, A. Mykoniatis, M. Buschmann, K.S. Matlin and J.B. 

Matthews. Univ. of Chicago. 

D420 

1002.14 Gender-dependent regulation of expression of 

the KCNQ1 channel regulatory b-subunit KCNE3 throughout 

the estrous cycle in rat distal colonic crypts. F. O’Mahony, R. 

Alzamora, D. Carter, W. Thomas and B.J. Harvey. Royal Col. 

of Surgeons in Ireland. 

D421 

1002.15 Intranasal theophylline: a novel method to treat 

patients with smell loss (hyposmia). R.I. Henkin, V. Gouliouk, 

M. Schultz and L. Minnick. Taste and Smell Clin., Washington, 

DC, Fndn. Care LLC, Earth City, MO and St. Louis Col. of 

Pharm. 

D422 1002.16 Reconstitution of nanosized HDL for targeted 

delivery of bioflavonoids. P. Khumsupan, C. Manansala and 

V. Narayanaswami. California State Univ., Long Beach. 

D423 1002.17 Renal cystic proteins in the olfactory epithelium. 

J.L. Pluznick, D.J. Rodriguez-Gil, M. Hull, K. Mistry, V.H. 

Gattone II, C. Johnson, S. Weatherbee, C. Greer and M.J. 

Caplan. Yale Univ. Sch. of Med., Indiana Univ. Sch. of Med. and 

Univ. of Leeds. 

D424 1002.18 CD133 expression is modulated at a posttranslational 

level during sodium butyrate-induced differentiation 

of HT29 human colon cancer cells. A. Sgambato, F. Errico, 

M.A. Puglisi, M. Corbi, A. Boninsegna, A. Rettino, G. 

Genovese, C. Coco, A. Gasbarrini and A. Cittadini. Catholic 

Univ., Rome. 

D425 1002.19 IRBIT regulates the WNK/SPAK pathway. D. 

Yang, Q. Li and S. Muallem. Univ. of Texas Southwestern 

Med. Ctr. 

D426 

1002.20 Apical expression and activity of Na-Cl 

cotransporters (NCC) in MDCK I TetOff cells does not require 

ncc phosphorylation. M.T.X. Nguyen, A.A. McDonough and 

A.S.L. Yu. USC Keck Sch. of Med. 

physiology 

D427 1002.21 WNK4 inhibits NCC protein expression through 

MAPK ERK1/2 signaling pathway. B. Zhou, Y. Zhang, D. Wang, 

J. Zhuang, X. Zhang, D. Gu and H. Cai. Emory Univ. Sch. of 

Med., Second Affiliated Hosp., Wenzhou Med. Col. and Fudan 

Univ. Sch. of Pharm., People’s Republic of China. 

D428 1002.22 Regulation of P-gp under inflammatory 

conditions in the BME-UV in vitro model. M.M. Al-bataineh, 

B.D. Schultz, D. van der Merwe, P. Malreddy and R. Gehring. 

Kansas State Univ. 

D429 

1002.23 Epithelial membrane pumps, channels and 

transporters as phenotypic markers of equine hoof keratinocytes 

in situ: an immunohistochemical study. K. Asplin, P. Harris and 

A. Mobasheri. Univ. of Nottingham and WALTHAM Ctr. for Pet 

Nutr., Melton Mowbray, U.K. 

D430 1002.24 Pufferfish Slc26a5 (prestin) exchanges Cl - for 

oxalate, sulfate, and bicarbonate. T. Hirata, A. Kato, M-H. 

Chang, S. Hirose and M.F. Romero. Mayo Clin. and Tokyo 

Inst. of Technol. 

D431 1002.25 Characterization of Anopheles gambiae 

Slc26a5 and potential role in malaria. L.R. Brin, T. Hirata, 

E.M. Scileppi, H.L. Holmes, P.J. Linser and M.F. Romero. 

St. Catherine’s Univ., MN, Mayo Clin. Col. of Med. and Whitney 

Lab., Univ. of Florida. 

D432 

1002.26 Dopamine inhibits the Na + /H + exchanger NHE3 

via protein phosphatase 2A. I.A. Bobulescu, H. Quiñones, 

S.M. Gisler, F. Di Sole, M. Shi, M-C. Hu, J. Zhang, D.G. Fuster, 

M. Mumby and O.W. Moe. Univ. of Texas Southwestern Med. 

Ctr. 

D433 

1002.27 Fk506 binding protein (FKBP12) may contribute 

to 4-chloro-m-cresol induced adenosine in human B cells. S. 

Bina, J. Capacchione, M. Bayarsaikhan, S. Muldoon and R. 

Bunger. Uniformed Svcs. Univ. of Hlth. Sci. 

D434 1002.28 Alternative splicing of the murine Tmem16a 

transcript in heart. K.E. O’Driscoll, W.J. Hatton and F.C. 

Britton. Univ. of Nevada Sch. of Med. 

D435 1002.29 Vasomotion in rat small mesenteric arteries is 

bestrophin-3 dependent. C. Aalkjær, T. Brøgger, D.B. Bødtkjer 

and V. Matchkov. Aarhus Univ., Denmark. 

D436 1002.30 Intestinal epithelial barrier integrity requires 

desmoglein2-mediated adhesion. N. Schlegel, M. Meir, W.M. 

Heupel, C.T. Germer and J. Waschke. Univ. of Würzburg, 

Germany. 

D437 

1002.31 Nedd4-2 interacts with occludin to inhibit tight 

junction formation and enhance paracellular conductance in 

collecting duct epithelia. N. Raikwar and C.P. Thomas. Univ. of 

Iowa and VA Med. Ctr. 

1003. Alcoholic and Nonalcoholic Fatty 

Liver Diseases 

Poster 



D438 1003.1 Betaine supplementation improved adipose 

tissue function in mice fed high-fat diet: a mechanism for 

hepatoprotective effect of betaine in nonalcoholic fatty liver 

disease. Z. Wang and Z. Song. Univ. of Illinois at Chicago. 

D439 1003.2 Rosiglitazone improves characteristics of 

non-alcoholic steatohepatitis in a mouse model of metabolic 

syndrome. A.A. Gupte, J.Z. Liu, L.J. Minze, Y. Ren, J.R. Wiles, 

A.R. Collins, C.J. Lyon and W.A. Hsueh. The Methodist Hosp. 

Res. Inst., Weill Cornell Med. Col., Houston. 

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Physiology 

1004. Barrier Function and Repair 

Poster 



D440 1004.1 Luminal ATP release is impaired in intestinal 

alkaline phosphatase knockout mice duodenum. Y. Akiba, 

C. Watanabe, T. Nakano, S. Narisawa, J.L. Millan and J.D. 

Kaunitz. Greater Los Angeles VA Healthcare Syst., UCLA and 

Burnham Inst for Med. Res., La Jolla. 

D441 1004.2 TNF is a key mediator in sepsis-induced 

intestinal barrier dysfunction but is independent of enterocyte 

NFkB. A.J. Samocha, C.M. Coopersmith and J.A. Dominguez. 

Washington Univ. Sch. of Med. and Emory Univ. Sch. of Med. 

D442 1004.3 Hibernation increases gut permeability and 

occludin expression in ground squirrel intestine. A.C. Pike and 

H.V. Carey. Univ. of Wisconsin-Madison. 

D443 1004.4 Vitamin D regulates MUC17 expression in 

Caco-2 cells. S.Q. Tabikh, E.Y.K. Tang and S. Resta. UCSD. 

D444 1004.5 Tissue damage causes hyperthermia-induced 

loss of intestinal barrier function via an oxidative stress pathway. 

T.L. Clanton, S.R. Oliver and M.P. Bakos. Univ. of Florida. 

D445 1004.6 Casein kinase 2 phosphorylates occludin at 

Ser408 to increase intra-tight junction diffusion and reduce 

paracellular barrier function. D.R. Raleigh, A. Marchiando, D. 

Boe, Y. Wang, L. Shen and J.R. Turner. Univ. of Chicago. 

D446 1004.7 Regional susceptibility of the small intestine to 

hyperthermia. N.A. Phillips, V.L. Novosad and T.L. Clanton. 

Univ. of Florida. 

D447 1004.8 Protection of the intestinal barrier in 

hyperthermia: defining the role of 12/15-lipoxygenase. V.L. 

Novosad, N.A. Phillips, S.R. Oliver and T.L. Clanton. Univ. of 

Florida. 

D448 1004.9 RhoA-dependent tight junction regulation 

is associated with dysregulated Akt and ERK signaling and 

increased claudin-2 expression. M. Gluth, U-F. Pape, F. 

Theuring and A. Fischer. Charité Med. Univ. Berlin. 

D449 1004.10 C-Src directly interacts with the C-terminal 

domain of occludin by involving SH2 and SH3 domains. A. 

Seth, G. Samak, C.E. Zola and R.K. Rao. Univ. of Tennessee 

Hlth. Sci. Ctr., Memphis. 

D450 1004.11 Osmotic stress-induced tight junction disruption 

in Caco-2 cell monolayers involves calcium-mediated JNK 

activation and JNKk-mediated MLCK activation. G. Samak and 

R.K. Rao. Univ. of Tennessee Hlth. Sci. Ctr., Memphis. 

1005. Epithelial Homeostasis and 

Gastrointestinal Cancer and 

Metastasis 

Poster 



D451 1005.1 Downregulation of CFTR is required for 

epithelial-mesenchymal transition in cancer development. 

J. Zhang, H. Chung and H.C. Chan. Sch. of biomed. Sci., 

Chinese Univ. of Hong Kong. 

D452 1005.2 Role of gut barrier dysfunction and endotoxemia 

in development of colon cancer cachexia. M.J. Puppa, J.P. 

White, S. Sato, J.W. Baynes and J.A. Carson. Univ. of South 

Carolina. 

1006. Gastric Physiology and 

Pathophysiology 

Poster 




D453 1006.1 Morphometrical analysis of ultrastructural 

transformation in gastric parietal cells reverting from the active 

to the resting state processed by high-pressure freezing. A. 

Sawaguchi and F. Toyoshima. Univ. of Miyazaki Fac. of Med., 

Japan. 

D454 1006.2 Effect of ezrin knockdown on the architecture 

of gastric epithelia. S. Asano, T. Tetsui, Y. Kobayakawa, A. 

Tamura, S. Tsukita, K. Mukaisho and T. Hattori. Ritsumeikan 

Univ., Osaka Univ. Grad. Sch. of Med. and Shiga Univ. of Med. 

Sci., Japan. 

1007. Gastrointestinal Development and 

Disease 

Poster 



D455 1007.1 Ontogenetic changes of histone modifications 

and polymerase II binding in the promoter region of rat 

intestinal sugar transporter genes in vivo. T. Suzuki, V. Douard, 

K. Mochizuki, T. Goda and R.P. Ferraris. UMDNJ-New Jersey 

Med. Sch. and Univ. of Shizuoka, Japan. 

D456 1007.2 Epidermal growth factor treatment prevents 

intestinal injury in weanling mice with septic peritonitis. J.A. 

Dominguez and C.M. Coopersmith. Washington Univ. Sch. of 

Med. and Emory Univ. Sch. of Med. 

D457 1007.3 Vascular endothelial growth factor protein is 

decreased in a mouse model of necrotizing enterocolitis. R. 

Carrasco, S.X.L. Liu, R. Tian, A. Kushnir and I.G. De Plaen. 

Children’s Mem. Res. Ctr./Northwestern Univ. 

D458 1007.4 Effects of aminoguanidine in a rat pancreatic 

tumor cell line. P. Chowdhury. Univ. of Arkansas for Med. Sci. 

D459 1007.5 Hnf1a is required for proper gut epithelial 

endocrine cell specification and controls the mTOR signalling 

pathway in mice. F. Boudreau, C.R. Lussier, F. Brial, N. Rivard 

and N. Perreault. Univ. of Sherbrooke, Canada. 

D460 1007.6 The SWI/SNF chromatin remodeling complex is 

required for GI smooth muscle development and differentiation. 

M. Zhang, M. Chen, J. Zhou and B.P. Herring. Indiana Univ. 

Sch. of Med. and Albany Med. Col. 

D461 1007.7 Functional deficits in IL -10 and phosphatidyl 

inositol-3 kinase contribute to the development of severe colitis. 

J.K. Uno, K. Matsuoka, S.Z. Sheikh, H. Elloumi, F. Li and 

S.E. Plevy. Univ. of North Carolina at Chapel Hill. 

D462 1007.8 Sonic Hedgehog signaling mediates bone 

marrow-derived mesenchymal stem cell proliferation and 

recruitment. J.M. Donnelly, A. Chawla, J. Houghton and Y. 

Zavros. Univ. of Cincinnati and Univ. of Massachusettes Med. 

Sch. 

D463 1007.9 Testosterone downregulates sodium-hydrogen 

exchanger isoform 8 expression. H. Xu, B. Zhang, J. Li, W. 

Tong, H. Chen, N. King and F.K. Ghishan. Univ. of Arizona. 

314

tuesday 

D464 1007.10 Loss of Sonic Hedgehog in the adult stomach 

results in foveolar hyperplasia and delayed differentiation of 

the zymogenic cell lineage. C. Xiao, J. Roland, K.T. Nam, J.R. 

Goldenring and Y. Zavros. Univ. of Cincinnati, Vanderbilt Univ. 

Med. Ctr. and Nashville DVA Med. Ctr. 

D465 1007.11 Palmitoylation of platelet-activating factor 

receptor is required for its lipid raft targeting and signaling. J. 

Lu, M.S. Caplan and T. Jilling. NorthShore Univ. Hlth.Syst., 

Evanston, IL. 

D466 1007.12 bArrestin2/barrestin1 ratio determines cell 

death or cell proliferation in response to platelet-activating 

factor. M. Issac, M.V. Pazin, M.S. Caplan and T. Jilling. 

NorthShore Univ. Hlth.Syst., Evanston, IL. 

D467 1007.13 TGF b supports, platelet-activating factor 

inhibits intestinal epithelial cell migration in vitro via effects on 

phoshatidylinositol 3 kinase. M.V. Pazin, J. Rudnicki, Y. Yang, 

M.S. Caplan and T. Jilling. NorthShore Univ. HealthSyst., 

Evanston, IL. 

1008. Gastrointestinal Motility 

Poster 



D468 1008.1 Neck position affects the dimensions of the 

rat cervical esophagus. M. Lorber. Georgetown Univ. Sch. of 

Med. 

D469 1008.2 17b Estradiol relaxes tension in male guinea 

pig gallbladder strips. L. Kline and E. Karpinski. Univ. of 

Alberta. 

D470 1008.3 Characterization of melatonin receptors and 

signaling pathways in gastrointestinal smooth muscle. R. 

Ahmed, S. Mahavadi, J.R. Grider and K.S. Murthy. Virginia 

Commonwealth Univ. 

D471 1008.4 Expression of PDE5 and its stimulation 

by cGMP-dependent protein kinase (PKG) determine the 

magnitude of smooth muscle relaxation in different regions of 

the stomach. O. Al-Shboul, S. Mahavadi, J.R. Grider and K.S. 

Murthy. Virginia Commonwealth Univ. 

D472 1008.5 Ghrelin enhances the regenerative potential of 

stem cells. M.A. Fahim, S. Karam and B. al-Ramadi. 

D473 1008.6 Plasticity of the noradrenergic response in 

gastric vagal circuits. K.N. Browning and R.A. Travagli. 

Pennington Biomed. Res. Ctr., Baton Rouge. 

D474 1008.7 Edema-induced alterations in the regulation of 

myosin light chain phosphorylation in intestinal smooth muscle. 

K. Uray, S. Shah and C.S. Cox. Univ. of Texas Med. Sch. at 

Houston. 

D475 1008.8 Activation of proteinase activated receptor-2 

inhibits spontaneous activity in rat colon. P.M. Kerr, A. Koshka 

and F. Plane. Univ. of Alberta. 

1009. GI Hormones, Peptides and Receptors 

Poster 



D476 1009.1 Linking a newly discovered hormone with 

orphan receptor candidates: the search for a cognate ligand. 

G. Miller, A.S. Salvatori, G.L.C. Yosten and W.K. Samson. 

Wartburg Col., IA and Saint Louis Univ. 

physiology 

D477 1009.2 Partial restoration of TG secretion via bile salt 

supplementation is sufficient to fully restore GIP secretion in 

bile-diverted rats. L. Li, Q. Yang, P. Tso and S. Yoder. Univ. of 

Cincinnati. 

D478 1009.3 Effect of ezetimibe on the response of incretin 

secretion to intestine lipid ingestion. L. Yang, X. Li, Y. Ji, D.Q-H. 

Wang, P.N. Howles, D.Y. Hui and P. Tso. Univ. of Cincinnati, 

Xi’an Jiaotong Univ., People”s Republic of China and Harvard 

Med. Sch. 

D479 1009.4 Functional characterization of ghrelin secreting 

A-like cells isolated from rat gastric mucosa. E. Nakamura, M. 

Hasumura, T. Matsumoto, A. San Gabriel, H. Uneyama and 

K. Torii. Ajinomoto Co. Inc., Kawasaki, Japan. 

D480 1009.5 Functional roles of calcium-sensing receptor. 

E. Nakamura, M. Hasumura, A. San Gabriel, H. Uneyama, Y. 

Eto and K. Torii. Ajinomoto Co. Inc., Kawasaki, Japan. 

1010. Growth Factors, Proliferation, 

Differentiation and Apoptosis 

Poster 



D481 1010.1 Translational regulation of CUG-BP1 by 

polyamines through the RNA-binding protein HuR. Y. Cui, L. 

Xiao, J.N. Rao, T. Zou, L. Liu, M. Gorospe and J-Y. Wang. 

Univ. of Maryland, Baltimore and NIA, NIH, Baltimore. 

D482 1010.2 Sigma1 receptors and neuroblastoma 

differentiation. J.M. Schrock, F.J. Kim and G.W. Pasternak. 

Weill Cornell Med. Col. and Mem. Sloan-Kettering Cancer Ctr. 

D483 1010.3 The combined administration of multiple soluble 

factors in the repair of chronically infarcted rat myocardium. 

H. Hwang and R.A. Kloner. Good Samaritan Hosp., Los 

Angeles. 

D484 1010.4 PGC-1 (peroxissome-proliferator activated 

receptor gamma coactivator 1) ab and melanoma growth: a 

possible energy-mediated relation. L.A. Passos and H.P. de 

Souza. Fac. Of Med., Univ. of São Paulo. 

D485 1010.5 Amino acids regulate expression of antizyme-1 

and modulate ornithine decarboxylase activation. R.M. Ray, 

M.J. Viar and L.R. Johnson. Univ. of Tennessee Hlth. Sci. Ctr., 

Memphis. 

D486 1010.6 The biological activity of proNGF is determined 

by the relative levels of TrkA and p75NTR receptors. M. 

Fahnestock, M.S. Ioannou and R. Masoudi. McMaster Univ., 

Canada. 

D487 1010.7 Induction of cellular responses and signaling 

pathways by bioassayable growth hormone. A.C. Tracy, Y. 

Ramos, G.V. Herrera, M.N. Serrano, R.D. Cooper and K.L. 

Gosselink. Canyon Hills Middle Sch. and Univ. of Texas at El 

Paso. 

1011. Hepcidin and Iron Homeostasis 

Poster 



D488 1011.1 Minihepcidins: small peptides involved in 

disulfide exchange with ferroportin act as agonists. G.C. Preza, 

P. Ruchala, E. Nemeth and T. Ganz. UCLA. 

315 

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Physiology 

D489 1011.2 Suppression of hepatic hepcidin expression 

in response to acute iron deficiency is correlated with an 

increase of matripatase-2 protein in the liver. A-s. Zhang, S.A. 

Anderson, J. Wang, F. Yang, K. DeMaster, R.S. Eisenstein, H. 

Tsukamoto and C.A. Enns. Oregon Hlth. & Sci. Univ., Univ. of 

Wisconsin-Madison, Univ. of Southern California and Caltech. 

D490 1011.3 The regulation of intestinal iron transport in 

a rat model of chronic renal failure. S.K. Srai, P.A. Sharp, J. 

Marks, R.J. Unwin and E.S. Debnam. University Col. London 

and King’s Col. London. 

D491 1011.4 Growth factors EGF and HGF suppress 

hepcidin by direct interference with bone morphogenetic protein 

signaling. J.B. Goodnough and T. Ganz. UCLA. 

D492 1011.5 Hepcidin independent anemia of inflammation. 

S. Rivera, D. Shprung, D. Limbrick, V. Gabayan and T. Ganz. 

UCLA. 

D493 1011.6 Identification of hepcidin antagonists through 

a high throughput screening approach. E. Fung, J. Hsu, 

R. Damoiseaux, T. Ganz and E. Nemeth. UCLA. 

1012. Immunology and Microbiology of the Gut 

Poster 



D494 1012.1 Characterization of FasL expression of rat 

mesenteric lymph node dendritic cells during inflammatory 

bowel disease. E. Rivera, F. Rodriguez and C.B. Appleyard. 

Ponce Sch. of Med., PR. 

D495 1012.2 Psychological stress and changes in the 

intestinal microflora impact memory in mice. M.G. Gareau, E. 

Wine, D.M. Rodrigues, M.T. Whary, G. MacQueen and P.M. 

Sherman. Hosp. for Sick Children, Toronto, MIT and Univ. of 

Calgary. 

D496 1012.3 Triclosan may alter the composition of 

the intestinal microbiota and increase the susceptibility to 

experimental murine colitis. E. Pasch and K.L.W. Walton. 

Missouri Western State Univ. 

D497 1012.4 Comparative analysis of innate immune related 

transcriptional responses to pathogens in Caenorhabditis 

elegans. K. Balamurugan and S. Karuthapandian. Alagappa 

Univ., India. 

D498 1012.5 Intestinal microbiome in transporter null mouse 

models. M.A. Engevik and R.T. Worrell. Univ. of Cincinnati. 

1013. Intestinal Inflammation and 


Poster 



D499 1013.1 Role of non-muscle myosin light chain kinase 

in neutrophil-mediated intestinal barrier dysfunction during 

thermal injury. M. Guo, C. Sun, Q. Shen, B.J. Frederich, M.H. 

Wu and S.Y. Yuan. Univ. of California Davis Sch. of Med. 

D500 1013.2 Oxidative stress inhibits Klotho activation of 

TRPV5 and TRPV6 in intestinal epithelial cells. M. Maruggi, 

A.T. Nguyen and S. Resta. UCSD. 


D501 1013.3 Tight junction protein expression by gD 

intraepithelial lymphocytes regulates interactions between 

lymphocytes and epithelial cells. K.L. Edelblum, A.M. 

Marchiando, L. Shen, Y. Wang, A.I. Sperling and J.R. Turner. 

Univ. of Chicago. 

D502 1013.4 Effect of stress on mucin-producing cells in the 

intestinal tract of mice. B.M. Habiyambere and E.M. Onyango. 

East Tennessee State Univ. 

D503 1013.5 Downregulation of aging-related Klotho gene 

in experimental colitis. R.D. Thurston, C.B. Larmonier, P.M. 

Majewski, R. Ramalingam, M.T. Midura-Kiela, D. Laubitz, 

A. Vandewalle, M. Mühlbauer, C. Jobin, P.R. Kiela and F.K. 

Ghishan. Univ. of Arizona, INSERM U773 Univ. Paris and Univ. 

of North Carolina at Chapel Hill. 

1014. Mechanisms of Intestinal Transport 

Poster 



D504 1014.1 Role of a non-CFTR chloride channel in 

intestinal epithelial chloride secretion. M.H. Kazi, O.M. 

Woodward, S.E. Guggino and C-M. Tse. Johns Hopkins 

Univ. 

D505 1014.2 MK571-sensitive extracellular ATP release in 

intestinal epithelia. T. Nakano, Y. Akiba, E. Engel, P.H. Guth 

and J.D. Kaunitz. CURE/UCLA, Greater Los Angeles VA 

Healthcare Syst. and UCLA. 

D506 1014.3 trans effects of Na + and glucose on Na + /glucose 

co-transport. C.S. Hummel, B.A. Hirayama, D.D.F. Loo and 

E.M. Wright. UCLA. 

D507 1014.4 Isolated cells of the sheep rumen and omasum 

express maxi-anion channels permeable to acetate, propionate 

and butyrate. F. Stumpff, M.I. Georgi and H. Martens. Free 

Univ. of Berlin. 

D508 1014.5 Segmental expression of H,K-ATPase-a2, 

KCC3, KCC4, and DRA in mouse distal colon is upregulated by 

dietary Na + restriction. C. Lytle, A. Evans, J.A. Payne and C. 

Talbot. Univ. of California, Riverside, Univ. of California, Davis 

and California State Univ., San Bernardino. 

1015. Novel Gastrointestinal Nutrient 

Sensors 

Poster 



D509 1015.1 Microbiota and dietary nutrients regulate 

digestive enzyme activity in the zebrafish intestine. I. Semova 

and J.F. Rawls. Univ. of North Carolina at Chapel Hill. 

D510 1015.2 Taste receptor-mediated duodenal bicarbonate 

secretion is associated with incretin release in rats. J. Wang, 

Y. Akiba, E. Engel, P.H. Guth and J.D. Kaunitz. UCLA and 

Greater Los Angeles VA Healthcare Syst. 

D511 1015.3 Enterocyte fatty acid oxidation may influence 

eating through vagal afferent signals. W. Langhans, C. Egle, 

G. Schober and M. Arnold. ETH Zurich. 

316

tuesday 

D512 1015.4 The G-protein coupled receptor GPR40 

mediates long chain fatty acid-induced cholecystokinin 

secretion. A.P. Liou, X. Lu, X. Zhao, S. Pechhold, H. Raybould 

and S. Wank. Sch. of Vet. Med., Univ. of California, Davis and 

NIDDK, NIH. 

D513 1015.5 Regulation of ghrelin production by gastric 

mTOR signaling. W. Zhang, G. Xu, Y. Li, W. An and M. 

Mulholland. Peking Univ. and Univ. of Michigan. 

1016. Pancreatic Physiology and 


Poster 



D514 1016.1 Time-course expression of PGC-1 in acute 

inflammation. F. Llimona, T.M. Lima-Salgado and H.P. de 

Souza. Fac. of Med., Univ. of São Paulo. 

D515 1016.2 JAK/STAT activation induced by angiotensin 

II in rats isolated pancreatic islets. E.S. Alves, A.A. Haidar, 

C.D. Quadors, D.S. Carvalho, D. Morgan, M.S. Rocha, A.R. 

Carpinelli and A.E. Hirata. Fed. Univ. of São Paulo and Univ. 

of São Paulo. 

D516 1016.3 Effect of chronic alcohol consumption on 

vitamin B1 (thiamine) uptake and metabolism by rat pancreatic 

acinar cells. T.S. Veerapazham and H.M. Said. Univ. of 

California, Irvine and VA Med. Ctr., Long Beach. 

1017. Vitamin, Trace Element and Metal Ion 

Transport 

Poster 



D517 1017.1 Erythropoietin regulates intestinal metal 

transporter expression. K. Pourvali, B. Chung and P.A. Sharp. 

King’s Col. London. 

D518 1017.2 Calcium interactions with divalent metal–ion 

transporter–1. A. Shawki and B. Mackenzie. Univ. of Cincinnati 

Col. of Med. and David Geffen Sch. of Med. at UCLA. 

D519 1017.3 Functional expression in Xenopus oocytes 

reveals that human ferroportin is an iron exporter shared with 

zinc. C.J. Mitchell, A. Shawki, E. Nemeth, T. Ganz and B. 

Mackenzie. Univ. of Cincinnati Col. of Med. and David Geffen 

UCLA Sch. of Med. and. 

1018. Mitochondrial Oxidants and 

Antioxidants in Autonomic Regulation 

and Cardiovascular Function 

Poster 



D520 1018.1 Increased mitochondrial expression of copper/ 

zinc superoxide dismutase (SOD1) following adenoviralmediated 

gene transfer inhibits angiotensin II intra-neuronal 

signaling. S. Li, R-F. Yang, J-X. Yin, H.D. Schultz and M.C. 

Zimmerman. Univ. of Nebraska Med. Ctr. 

physiology 

D521 1018.2 Therapeutic targeting of mitochondrial 

superoxide in hypertension. S. Dikalov, A. Bikineyeva, K. 

Budzyn, R. Nazarewicz, W. Lewis, D.G. Harrison and A. 

Dikalova. Emory Univ. Sch. of Med. 

D522 1018.3 ACE2 inhibits angiotensin-II mediated NADPH 

oxidase activation in the central nervous system. H. Xia, S. 

Suda, P. Xu, K.H. Chhabra and E. Lazartigues. LSU Hlth. Sci. 

Ctr., New Orleans. 

D523 1018.4 Mitochondrial complex I deficiency is one of 

the major causes of mitochondrial oxidative stess in Zucker 

obese fatty rat. Y.F. Pung, J.L. Hafemeister and W.M. Chilian. 

Northeastern Ohio Univs. Col. of Med. and Pharm. 

D524 1018.5 Elevated angiotensin II attenuates activation of 

voltage-gated sodium channels in heart failure rats: involvement 

of mitochondria-derived superoxide. L. Zhang, H. Zheng, H. 

Tu, T.P. Tran, R.L. Muelleman, M.C. Zimmerman and Y-L. Li. 

Univ. of Nebraska Med. Ctr. 

D525 1018.6 Autonomic control and antioxidant status during 

early pregnancy in formerly preeclamptic women. B. Janssen, 

D. Courtar, T. Ekhart, G. Haenen and L. Peeters. Maastricht 

Univ., Netherlands. 

D526 1018.7 Oral intake of rosiglitazone promotes central 

antihypertensive effect via upregulation of mitochondrial 

uncoupling protein and alleviation of oxidative stress in rostral 

ventrolateral medulla of spontaneously hypertensive rats. 

S.H.H. Chan, A.Y.W. Chang and J.Y.H. Chan. Chang Gung 

Mem. Hosp. and Kaohsiung Veterans Gen. Hosp., Taiwan. 

D527 1018.8 Antioxidant intravenous supplementation 

improves cardiac output during dynamic exercise in college 

soccer athletes. J-M. Chun, J-J. Kwak, H-M. Choi, S. Park, 

J-H. Lee, J-K. Kim, J.W. Jung and H. Nho. Grad. Sch. of Phys. 

Educ., Kyung Hee Univ., Republic of Korea. 

1019. Neural Control and Autonomic 

Regulation: Midbrain and 

Hypothalamus 

Poster 



D528 1019.1 Sinoaortic denervation prevents traininginduced 

plasticity in preautonomic oxytocinergic and 

vasopressinergic pathways. M.T. Cavalleri, K. Burgi, M.T. 

Jordao, A. Ceroni, J.C. Cruz and L.C. Michelini. Univ. of São 

Paulo. 

D529 1019.2 Activated projection from arcuate nucleus to 

ventrolateral periaqueductal gray during electroacupuncture: 

relation to neurons containing VGLUT3. Z. Guo, Y. Liu and J.C. 

Longhurst. Univ. of California, Irvine. 

D530 1019.3 Cannabinoid receptor modulation of the 

defense response in the dorsal periqueductal gray. C. Dean 

and F. Hopp. Med. Col. of Wisconsin and Zablocki VA Med. 

Ctr. 

D531 1019.4 Increased expression of carboxy-terminal PDZ 

ligand of nNOS within the paraventricular nucleus of rats with 

heart failure. N.M. Sharma, H. Zheng, Y-F. Li and K.P. Patel. 

Univ. of Nebraska Med. Ctr. and Univ. of South Dakota. 

D532 1019.5 Altered expression of heme oxygenase-1 in the 

hypothalamic paraventricular nucleus of heart failure rats. V.C. 

Biancardi, S.J. Son and J.E. Stern. Med. Col. of Georgia. 

t 

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317

Physiology 

D533 1019.6 Altered balance of excitatory/inhibitory synaptic 

inputs in supraoptic and paraventricular neurosecretory 

neurons in heart failure rats. E. Potapenko, V.C. Biancardi 

and J.E. Stern. Med. Col. of Georgia. 

D534 1019.7 Hypothalamic corticotrophin releasing hormone 

and norepinephrine contribute to sympathoexcitation in heart 

failure. Y-M. Kang, X-J. Yu, Y-l. Guo, N. Yan, J. Qi, L-M. Yang, 

D-N. Qin, C. Elks and J. Francis. LSU and Shanxi Med. Univ. 

and Shantou Univ. Med. Col., People’s Republic of China. 

D535 1019.8 Reduced reactive oxygen species generation in 

rostral ventrolateral medulla suppresses the pressor response 

induced by the excitation of the paraventricular nucleus of 

the hypothalamus in spontaneously hypertensive rats. M. 

Nishihara, Y. Hirooka, R. Matsukawa, K. Ito, T. Kishi and K. 

Sunagawa. Kyushu Univ. Grad. Sch. of Med. Sci., Japan. 

D536 1019.9 Altered blood brain barrier integrity in 

hypertensive rats: role of angiotensin II. S.J. Son, S. Ahmadi, 

J.A. Filosa and J.E. Stern. Med. Col. of Georgia. 

D537 1019.10 Increased sympathoexcitation to angiotensin 

II and AT 1 

receptor mRNA in the paraventricular nucleus of 

pregnant rats. C.M. Heesch, L.I. Kvochina and S. Burcks. 

Univ. of Missouri-Columbia. 

D538 1019.11 Ionotropic glutamate receptors in the 

paraventricular nucleus are required for sympathoexcitation 

due to angiotensin II in the subfornical organ of nonpregnant 

and pregnant rats. L.I. Kvochina, E.M. Hasser and C.M. 

Heesch. Univ. of Missouri-Columbia. 

D539 1019.12 Expression of soluble epoxide hydrolase in 

brains of female offspring of rats fed high salt during pregnancy. 

J.P. Porter, C.L. Johnson and K. Rogers. Brigham Young 

Univ. 

D540 

1019.13 Role of CK2 and calcineurin in increased 

NMDA receptor activity of PVN presympathetic neurons in 

hypertension. Z. Ye, D-P. Li and H-L. Pan. Univ. of Texas M.D. 

Anderson Cancer Ctr. 

D541 

1019.14 Enhanced activation of the median pre-optic 

nucleus contributes to the activation of the paraventricualr 

nucleus in heart failure. H. Zheng, X. Liu and K.P. Patel. Univ. 

of Nebraska Med. Ctr. 

D542 

1019.15 The hypothalamic paraventricular nucleus 

is required for insulin’s action to increase baroreflex gain of 

lumbar sympathetic nerve activity. P.A. Cassaglia and V.L. 

Brooks. Oregon Hlth. & Sci. Univ. 

D543 

1019.16 Dorsomedial hypothalamus and medullary 

raphe mediate respiratory arousal responses in rats. E. 

Nalivaiko, M.I. Beig, C.H. Xavier and M.A.P. Fontes. Univ. of 

Newcastle, Australia and Fed. Univ. of Minas Gerais, Brazil. 

D544 1019.17 Involvement of the paraventricular nucleus of 

the hypothalamus in cardiovascular and autonomic modulation 

during LPS endotoxemia in awake rats. M.C. Martins-Pinge, 

S.B. de Abreu and P. Pinge-Filho. State Univ. of Londrina, 

Brazil. 

D545 1019.18 Chronic increases in dorsal hindbrain 

corticosterone (Cort) enhance the blood pressure response to 

restraint stress without changing peripheral Cort. D.L. Daubert, 

Y. Dong and D.A. Scheuer. Ferris State Univ. and Univ. of 

Florida. 

D546 1019.19 Hypothalamic regions activated during 

voluntary exercise and airpuff startle. R. Dampney, A. Lam, J. 

Horiuchi, L. McDowall, T. Furlong, K. Iiigaya and J. Polson. 

Univ. of Sydney. 

D547 1019.20 Cardiac chronotropic and inotropic responses 

evoked from right or left sides of dorsomedial hypothalamus. 

C.H. Xavier, M.I. Beig, D. Ianzer, M.P. Fontes and E. Nalivaiko. 

Fed. Univ. of Minas Gerais, Brazil, Sch. of Biomed. Sci., Univ. of 

Newcastle, Australia and Butantan Inst., São Paulo. 

D548 1019.21 Involvement of the cholinergic system of the 

posterior hypothalamic nucleus during the reflex compensatory 

response to hemorrhage. Z.T. Webb and J.R. Martin. A.T. Still 

Univ. Hlth. Sci., Kirksville Col. of Osteo Med. and California 

Northstate Col. of Pharm. 

1020. Neural Control in Humans 

Poster 



D549 1020.1 Effect of melatonin on the vestibulocollic reflex 

in humans. J.S. Cook, S.A. Chin-Sang, C.L. Sauder and C.A. 

Ray. Penn State Col. of Med. 

D550 1020.2 Relationship between breathing and 

cardiovascular function at rest: sex related differences. E.A. 

Wehrwein, E.C. Hart, N. Charkoudian, M.J. Joyner, R.J. 

Widmer, J.H. Eisenach and B.G. Wallin. Mayo Clin. and 

Sahlgren Acad., Gothenburg Univ., Sweden. 

D551 1020.3 Influence of progesterone and estradiol on 

cardiovagal baroreflex sensitivity in young healthy women. E.R. 

Martini, J.A. Miner, V.E. Brunt, M.M. Smith, P.F. Kaplan, J.R. 

Halliwill and C.T. Minson. Univ. of Oregon. 

D552 1020.4 Alterations in carotid baroreflex control of 

arterial blood pressure during the menstrual cycle in young 

women. A. Kim, S.H. Deo, J.P. Fisher and P.J. Fadel. Univ. of 

Missouri-Columbia and Univ. of Birmingham, U.K. 

D553 1020.5 Acute alcohol ingestion blunts arterial pressure 

but not sympathetic neural responses to orthostatic stress in 

humans. S.F. Stream, C.E. Schwartz, J.C. Klein and J.R. 

Carter. Michigan Technol. Univ. 

D554 1020.6 Autonomic control of heart rate by the muscle 

metaboreflex in humans. J.P. Fisher, T. Seifert, D. Hartwich, 

C.N. Young, N.H. Secher and P.J. Fadel. Univ. of Birmingham, 

UK, Univ. of Copenhagen and Univ. of Missouri-Columbia. 

D555 1020.7 Augmented skeletal muscle metaboreflex 

function in hypertensive adults. E.P. Delaney, D.G. Edwards, 

W.C. Rose, P.J. Fadel and W.B. Farquhar. Univ. of Delaware 

and Univ. of Missouri-Columbia. 

D556 1020.8 Prehypertension alters arterial pressure and 

forearm vascular responses to mental stress in humans. C.E. 

Schwartz, J.J. Durocher and J.R. Carter. Michigan Technol. 

Univ. and St. Francis Univ., PA. 

D557 1020.9 Combined heat and mental stress alters 

neurovascular control in humans. J.C. Klein, C.G. Crandall, 

R.M. Brothers and J.R. Carter. Michigan Technol. Univ. and 

Texas Hlth. Presbyterian Hosp., Dallas. 

D558 

1020.10 High sodium intake alters the hemodynamic 

response to mental stress in normotensive subjects after 

systemic beta adrenergic blockade. B.M. Silva, R.L. Elvebak, 

J.N. Knutson, N.D. Warner, M.J. Joyner and J.H. Eisenach. 

Rio de Janeiro State Univ. and Mayo Clin. 

D559 


1020.11 Adrenergic tone does not tonically restrain limb 

venous compliance in healthy humans. J.A. Sielatycki, S.J. 

Spilk and K.D. Monahan. Penn State Col. of Med. 

318

tuesday 

D560 1020.12 The influence of beat-to-beat changes in 

muscle sympathetic nerve activity on vascular conductance 

in humans. S.T. Fairfax, C.N. Young and P.J. Fadel. Univ. of 

Missouri-Columbia. 

D561 1020.13 Impact of increased muscle sympathetic 

nerve activity on conduit artery shear rate patterns. J. Padilla, 

C.N. Young, G.H. Simmons, S.H. Deo, S.C. Newcomer, J.P. 

Sullivan, M.H. Laughlin and P.J. Fadel. Univ. of Missouri- 

Columbia and Purdue Univ. 

D562 1020.14 Autonomic regulation in patients with diabetic 

neuropathy. S. Wang, D.C. Randall, C.F. Knapp, K.R. Nelson, 

A.R. Patwardhan, P.J. Kilfoil and J.M. Evans. Univ. of 

Kentucky. 

D563 1020.15 Nonlinear phase synchronization changes 

between SBP and R-R interval precede syncope in the young. 

A.J. Ocon, M. Medow, I. Taneja and J.M. Stewart. New York 

Med. Col., Valhalla and Hawthorne, NY. 

D564 1020.16 Aging leads to a loss of cardiac nonlinear 

dynamics during sleep stages as assessed by statistical 

irreversibility. K.R. Casali, A.U. Viola, S.L. Chellappa, E. 

Tobaldini, A.G. Casali, A. Porta and N. Montano. Inst. of 

Cardiol., Porto Alegre, Brazil, Univ. of Basel and Univ. of Milan. 

D565 1020.17 Cardiac autonomic regulation in hyperthyroid 

subjects during sleep. E. Tobaldini, M. Pecis, M. Bulgheroni, 

S. Colombo, M. Muratori, M. Bevilacqua, A. Porta and N. 

Montano. Sacco Hosp., Milan and Univ. of Milan. 

D566 1020.18 Abnormal reactivity of afferent neuronal 

pathway from the heart to the brain in heart failure patients. H. 

Suzuki, M. Hirose, Y. Wakayama, S. Watanabe, S. Miura, S. 

Fukudo and H. Shimokawa. Tohoku Univ. Grad. Sch. of Med. 

and Tohoku Univ. Hosp., Japan. 

1021. Physiological Genomics and 

Proteomics 

Poster 



D567 1021.1 Sex-dependent molecular alterations during 

development of alcoholic cardiomyopathy in rat. R.L. Fogle 

and T.C. Vary. Penn State Col. of Med. 

D568 1021.2 Toward comprehensive quantitative proteomics 

using subcellular fractionation and LC-MS/MS. K. Luginbuhl, T. 

Pisitkun, M. Rinschen, J. Hoffert and M.A. Knepper. NHLBI, 

NIH. 

D569 1021.3 Proteomic evaluation of chicken brush-border 

membrane during the early post-hatch period. E.R. Gilbert, 

P.M. Williams, W.K. Ray, H. Li, D.A. Emmerson, E.A. Wong 

and K.E. Webb, Jr. VPI and State Univ. and Aviagen, Huntsville, 

AL. 

D570 1021.4 Molecular effect pathways involved in 

crustacean molting and in its disruption. L. Tumburu, Y. Gao 

and M.G. Wheatly. Wright State Univ. 

D571 1021.5 Genetic variation of the alpha subunit of the 

epithelial Na + channel influences exhaled Na + in response to 

albuterol in humans. W.T. Foxx-Lupo, C.M. Wheatley, N.A. 

Cassuto, E.C. Wong, A.E. Patanwala, N.A. Delamere and 

E.M. Snyder. Univ. of Arizona. 

D572 1021.6 Gender dimorphism in the exercise-naïve 

murine skeletal muscle proteome. L.A. Metskas, M. Kulp and 

S.P. Scordilis. Smith Col. 

D573 1021.7 Chronic tracheal occlusion conditioning 

modulates gene expression in the medial thalamus. V. 

Bernhardt, M. Hotchkiss, N.G. Reyero Vinas, N. Denslow 

and P.W. Davenport. Univ. of Florida and Jackson State Univ. 

D574 1021.8 Survival time after hemorrhage in inbred rats 

with known blood volumes. H.G. Klemcke, R. Rose, T. Oh and 

M.L. Calderon. U.S. Army Inst. of Surg. Res., San Antonio. 

D575 1021.9 Proteasome inhibition suppresses 

injury-induced myelin ovoid formation and Schwann cell 

dedifferentiation in the peripheral nerves. H.T. Park, H.K. Lee, 

Y.K. Shin, J. Jung, D.J. Suh, D-H. Lee and S.Y. Baek. Col. of 

Med., Dong-A Univ. and Pusan Natl. Univ. Med. Sch., Republic 

of Korea. 

1022. Hypoxia as an Effector/Modulator 

Poster 



D576 1022.1 Differential regulation of HIF-1 alpha and 

VEGF in an anoxia-tolerant brain. S.L. Milton, S. Kesaraju, K. 

Ayyanathan and H. Prentice. Florida Atlantic Univ. 

D577 1022.2 The role of methionine sulfoxide reductase A in 

the anoxia-tolerant turtle (Trachemys scripta). L.E. Bruce and 

S.L. Milton. Florida Atlantic Univ. 

D578 1022.3 Intermittent hypoxia conditioning reduces 

DOR-2 receptors in the canine SA node and improves vagal 

transmission. R.T. Mallet, H.F. Downey, G.M. Denning, M.A. 

Barlow and J.L. Caffrey. Univ. of North Texas Hlth. Sci. Ctr., 

Univ. of Iowa and Penn State. 

D579 1022.4 Anti-hypertensive action of intermittent 

hypoxia in young spontaneously hypertensive rats. D. Jasti, E. 

Manukhina, A. Williams, Jr, L. Howard and F. Downey. Univ. 

of North Texas Hlth. Sci. Ctr. at Fort Worth and Inst. of Gen. 

Pathol. and Pathophysiol., Moscow. 

D580 1022.5 Reduction of Na/H exchanger-1 expression 

limits cardiac injury in mice with chronic intermittent hypoxia. L. 

Chen, J. Zhang, V. Prasad and S.M. Scharf. Univ. of Maryland 

Baltimore and Univ. of Cincinnati Col. of Med. 

D581 1022.6 Role of endothelium-derived hyperpolarizing 

factor in hypoxia-induced vasodilation in humans. U.A. 

Leuenberger, S. Spilk, J. Yoder, C. Blaha and J. Mast. Penn 

State Hershey Med. Ctr. 

D582 1022.7 Effect of AT1 receptor blockade on intermittent 

hypoxia-induced endothelial dysfunction. N.J. Marcus, N.R. 

Philippi, C.E. Bird, H.D. Schultz, Y. Li and B.J. Morgan. Univ. 

of Wisconsin-Madison and Univ. of Nebraska Med. Ctr. 

D583 1022.8 Intermittent hypoxia causes pre-diabetes like 

conditions in rats. X.A. DeLeon, L. Aguirre, K. Colleran and 

N. Kanagy. Univ. of New Mexico. 

D584 1022.9 Hypoxia induced periventricular white matter 

damage in the developing brain. C. Kaur and S.S.W. Tay. Natl. 

Univ. of Singapore. 

D585 1022.10 The time course of transcriptional regulation 

in anoxic fibroblasts: implications for carpal tunnel syndrome. 

C.W. Pierce, M.A. Tucci and H. Benghuzzi. Sch. of Hlth. 

Related Professions, Univ. of Mississippi Med. Ctr. 

D586 

physiology 

1022.11 Hyaluronic acid attenuates expression of HIF- 

1 alpha and iNOS in experimental rheumatoid arthritis. P-L. 

Chang, Y-L. Hsieh, P-W. Tu, L-W. Chou and H-C. Ou. China 

Med. Univ., Taiwan. 

t 

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319

Physiology 

1023. Pulmonary Hypertension: Mechanisms 

and Mediators 

Poster 



D587 1023.1 Reactive oxygen species-mediated activation 

of NFAT leads to pulmonary hypertension. L.V. Gonzalez 

Bosc, C. Nitta and J. Friedman. Univ. of New Mexico. 

D588 1023.2 Role of glucose-6-phosphate dehydrogenase 

in chronic hypoxia-induced pulmonary hypertension. S. 

Chettimada, M. Oka, I.F. McMurtry and S.A. Gupte. Univ. of 

South Alabama. 

D589 1023.3 Bmp2 and Bmp4 exert opposing effects in 

hypoxic pulmonary hypertension. M.P. de Caestecker, L. 

Anderson, M. Jones and J. Lowery. Vanderbilt Univ. 

D590 1023.4 Aberrant eNOS phosphorylation in idiopathic 

pulmonary arterial hypertension. S. Ghosh, L. Mavrakis, A.J. 

Janocha, S.A.A. Comhair and S.C. Erzurum. Cleveland 

Clin. 

D591 1023.5 Protein kinase G deficiency induces pulmonary 

hypertension in mice and humans. Y-Y. Zhao, M.K. Mirza, S. 

Sun, K. Wasiukanis, S.M. Vogel, F. Hofmann and Y. Zhao. 

Univ. of Illinois at Chicago and Tech Univ. Munich. 

D592 1023.6 Novel role of pre-B-cell colony enhancing 

factor in pulmonary arterial hypertension. R.F. Machado, 

L. Moreno-Vinasco, E. Chiang, S.R. Zaidi, S. Sammani, 

T. Mirzapoiazova, P.T. Toth, M. Ayetkin, R.A. Dweik, S.L. 

Archer and J.G.N. Garcia. Univ. of Chicago and Cleveland 

Clin. Fndn. 

D593 1023.7 The role and regulation of inhibitor of 

differentiation family members in hypoxic pulmonary 

hypertension. J.W. Lowery, L. Anderson, M. Jones and M.P. 

de Caestecker. Vanderbilt Univ. 

D594 1023.8 Differential changes of BNIP3 and beclin-1 

during the right ventricle response to sustained or intermittent 

hypoxia. J. Zhang, A. Joy, Q. Dai, S. Mifflin and M.L. Lindsey. 

Univ. of Texas Hlth. Sci. Ctr. at San Antonio and Univ. of North 

Texas Hlth. Sci. Ctr. 

D595 1023.9 Exercise training has protective effects in 

monocrotaline-induced pulmonary hypertension. D. Moreira- 

Gonçalves, T. Henriques-Coelho, H. Fonseca, N. Gonçalves, 

M. Ferreira-Pinto, M. Dias-Neto, F. Vasques-Novoa, A. Leite- 

Moreira and J.A. Duarte. Fac. of Sport and Fac. of Med., Univ. 

of Porto, Portugal. 

D596 1023.10 Early intervention is important for inhibiting 

pulmonary hypertension progression. J-S. Ou, Z-j. Ou, W. 

Wei, D-d. Huang, Z-p. Wang and X. Zhang. First Affiliated 

Hosp., Sun Yat-sen Univ. and First Municipal People’s Hosp., 

Guangzhou, People’s Republic of China. 

D597 1023.11 Effect of digoxin on hypoxic pulmonary 

hypertension. E. Abud, C. Undem, J.T. Sylvester, G.L. 

Semenza and L.A. Shimoda. Johns Hopkins Sch. of Med. 

D598 1023.12 The novel soluble guanylate cyclase activator 

PPCA reverses acute hypoxia-induced pulmonary hypertension 

in dogs. T. Wang, G.P. McCefferty, C.G. Schnackenberg, B.M. 

Jucker, R.N. Willette and D.J. Behm. GlaxoSmithKline. 

D599 

1023.13 Antenatal maternal hypoxic stress: epigenetic 

adaptations in fetal lung renin-angiotensin system. R. Goyal, 

A. Leitzke, D. Goyal, C.P. Gheorghe and L.D. Longo. Loma 

Linda Univ. 

D600 1023.14 Epigenetic programming of pulmonary vascular 

dysfunction in mice. E. Rexhaj, C. Sartori and U. Scherrer. 

CHUV, Lausanne. 

D601 1023.15 In utero hypoxia augments hypoxic pulmonary 

vasoconstriction in newborn lamb. S.M. Wilson, D.G. 

Papamatheakis, M.R. Terry, T. Merritt, J. Merrill-Henry, H. 

Schroeder, L.D. Longo and A.B. Blood. Loma Linda Univ. 

Sch. of Med. 

D602 1023.16 Synergism between Ca 2+ and Rho-kinase 

signaling during pulmonary arterial vasoconstriction in chronic 

hypoxic newborn lamb. D.G. Papamatheakis, S. Vemulakonda, 

T. Merritt, L.D. Longo, A.B. Blood and S.M. Wilson. Loma 

Linda Univ. Sch. of Med. 

D603 1023.17 Regulation of vascular smooth muscle 

contraction by Ca 2+ signaling and Ca 2+ sensitivity in 

intrapulmonary arteries. J.F. Perez-Zoghbi, S. Mukherjee and 

M.J. Sanderson. Texas Tech Univ. Hlth. Sci. Ctr. and Univ. of 

Massachusetts Med. Sch. 

D604 1023.18 ASIC1 mediates enhanced receptor-mediated 

vasoconstriction following chronic hypoxia-induced pulmonary 

hypertension. N.L. Jernigan, B.R. Walker and T. Resta. Univ. 

of New Mexico Hlth. Sci. Ctr. 

D605 1023.19 Role of NADPH oxidase in enhanced 

membrane depolarization-induced Ca 2+ -sensitization in 

pulmonary vascular smooth muscle following chronic hypoxia. 

C.E. Norton III, B. Broughton, B.R. Walker and T. Resta. Univ. 

of New Mexico. 

D606 1023.20 Contribution of mitochondrial reactive oxygen 

species to increased pulmonary vasoconstrictor reactivity 

following intermittent hypoxia. J. Snow, N. Kanagy, B.R. Walker 

and T. Resta. Univ. of New Mexico. 

D607 1023.21 Neprilysin peptidase-independent complex 

formation in pulmonary artery smooth muscle cells. M.J. Wick, 

Y.E. Miller and E.C. Dempsey. Univ. of Colorado Denver, 

Aurora and Denver VA Med. Ctr. 

D608 

1023.22 PDGF-BB signaling in adventitial fibroblasts 

during hypoxia-induced pulmonary hypertension. E. 

Panzhinskiy, K. Shields, M. Zawada, K. Stenmark and M. 

Das. Univ. of Wyoming and Univ. of Colorado Denver, Aurora. 

D609 

1023.23 Protein kinase A and exchange protein directly 

activated by cAMP in human pulmonary artery smooth muscle 

cells: expression, function and downstream signaling. O. Kwon, 

F. Murray and P.A. Insel. UCSD. 

D610 

1023.24 Reciprocal regulation of Na + /H + exchanger 

isoform 1 and Na + /H + exchange regulatory factor 1 in hypoxic 

pulmonary arterial smooth muscle cells. J.A. Maylor, W. Lu, S. 

Pisarcik, J. Walker, C. Undem, A.C. Myers and L.A. Shimoda. 

Johns Hopkins Univ. Sch. of Med. 

D611 1023.25 Characterization of ion channels in progenitor 

cells isolated from CTEPH patients. A.L. Firth, O. Platoshyn, 

E. Cancino and J.X-J. Yuan. UCSD. 

D612 1023.26 Role of caldesmon in hypoxia-mediated 

endothelial cell response. A.A. Desai, L. Moreno-Vinasco, 

D.S. Parikh, A. Gera and J.G.N. Garcia. Univ. of Chicago. 

D613 


1023.27 Impact of hyperthyroidism and its correlation on 

regional blood flow in rats. D.A. Gomes, C. Mostarda, L. Jorge, 

K. De Angelis, M.C. Irigoyen and M.L. Barreto-Chaves. Univ. 

of São Paulo and São Judas Tadeu Univ., Brazil. 

320

tuesday 

1024. Ion Transport, Acid Base, Organic 

Solute, Water Urea, Gender 

Poster 



D614 1024.1 The Rab-GAP, AS160, participates in the 

regulation of apical membrane epithelial sodium channel 

density and recycling. X. Liang, M. Butterworth, K.W. Peters 

and R.A. Frizzell. Univ. of Pittsburgh. 

D615 1024.2 Role of dopamine in modulating flow-dependent 

sodium and bicarbonate transport in mouse proximal tubule. 

Z. Du, Q. Yan, S. Weinbaum, A.M. Weinstein and T. Wang. 

Yale Univ., City Col. of New York and Weill Med. Col. of Cornell 

Univ. 

D616 1024.3 Pseudohyperkalaemia induced by blood 

collection and corrections for hemolysis in blood samples from 

experimental mice. Q. Yan, Z. Du, N. Gotoh, G. Giebisch and 

T. Wang. Yale Univ. 

D617 1024.4 Phospholipase A2 group VIA regulates Na- 

K-2Cl cotransporter activity in the thick ascending limb. T. 

Roeschel, S. Seidel, T. Kahl, K. Mutig, R. Mrowka, Q. Shan, 

M. Bleich, N.R. Ferreri, S. Bachmann and A. Paliege. Charité, 

Berlin, Christian Albrechts Univ. Kiel and New York Med. Col. 

D618 1024.5 Urinary proteomics analysis of a high salt diet. 

C.A. Jackson, S. Mangaroo, R.E. Ward, C.J. Robertson and 

C.A. Jackson. Tuskegee Univ. 

D619 1024.6 V-ATPase membrane accumulation and 

activity are stimulated by cAMP in A-type intercalated cells. 

T.G. Paunescu, M. Ljubojevic, L.M. Russo, C. Winter, 

M.M. McLaughlin, C.A. Wagner, S. Breton and D. Brown. 

Massachusetts Gen. Hosp., Harvard Med. Sch. and Inst. of 

Physiol and Zurich Ctr. for Integrat. Human Physiol. 

D620 1024.7 Effect of knocking out receptor protein tyrosine 

phosphatase g in the CO 2 

-induced stimulation of HCO 3 

reabsorption by mouse renal proximal tubules. Y. Zhou and 

W.F. Boron. Sch. of Med., Case Western Reserve Univ. 

D621 1024.8 Effect of knocking out receptor protein tyrosine 

phosphatase g in the HCO 3 

-induced inhibition of HCO 3 

reabsorption by mouse renal proximal tubules. Y. Zhou. Sch. of 

Med., Case Western Reserve Univ. 

D622 1024.9 Na/bicarbonate cotransporter NBCn1 is 

upregulated under acidic conditions and enhances ammonium 

transport in the kidney medullary thick ascending limb cell 

line. S. Lee, H.J. Lee, H.J. Park, H.S. Yang, D. Cucoranu, I. 

Rajbhandari, D.S. Cooper and I. Choi. Emory Univ. Sch. of 

Med. 

D623 1024.10 Altered bicarbonate-dependent intracellular pH 

regulation in a cortical collecting duct principal cell line from a 

mouse model of autosomal recessive polycystic kidney disease. 

X. Liu, L.A. Stephens, D. Olteanu and M.O. Bevensee. Univ. 

of Alabama at Birmingham. 

D624 1024.11 Influence of [H + ] on MPP efflux from CHO cells 

expressing hMATE1. Y. Dangprapai and S.H. Wright. Univ. of 

Arizona. 

D625 1024.12 Multidrug and toxin extrusion’s role in renal 

organic cation secretion. B. Astorga, L.L. Hook and S.H. 

Wright. Univ. of Arizona. 

D626 1024.13 Inhibition of AMP-activated kinase mitigates 

zinc-induced inhibition of urate secretion. A.M. Bataille, C. 

Maffeo and J.L. Renfro. Univ. of Connecticut. 

physiology 

D627 1024.14 Breast cancer resistant protein (Bcrp, Abcg2) 

contributes to active urate secretion in mouse and bird renal 

proximal tubule. A.M. Bataille and J.L. Renfro. Univ. of 

Connecticut. 

D628 1024.15 Regulation of apical choline transport in 

cultured choroid plexus by oxidative stress. A.R. Villalobos 

and R.K. Young. Texas A&M Univ. 

D629 1024.16 Sodium dicarboxylate transporters in placental 

cells. K.S. Hering-Smith, J. Coleman-Barnett, M. Yu, S. 

Abdulnour-Nakhoul and L.L. Hamm. Southeast Louisiana 

Veterans Hlth. Care Syst. and Tulane Univ. Hlth. Sci. Ctr. 

D630 1024.17 Effect of chronic alcohol feeding on vitamin B1 

(thiamine) transport in rat kidneys. V.S. Subramanian, S.B. 

Subramanya and H.M. Said. Univ. of California, Irvine and VA 

Med. Ctr., Long Beach. 

D631 1024.18 Serine 575 accounts for difference in thiazide 

affinity between mammalian and flounder NCC. M. Castañeda- 

Bueno, N. Vazquez, D. Hernandez, E. Rodriguez-Lobato, E. 

Moreno and G. Gamba. UNAM-INNSZ-INCICH, Mexico City 

and Univ. Autonoma del Estado de Hidalgo, Mexico. 

D632 1024.19 Vasopressin-regulated phosphorylation of urea 

transporter proteins, UT-A1 and UT-A3, in rat inner medullary 

collecting duct. S. Hwang, C-L. Chou, M-J. Yu, M. Rinschen, 

R. Gunaratne, T. Pisitkun, J.D. Hoffert and M.A. Knepper. 

D633 1024.20 Hypertonicity increases urea permeability 

through PKC in inner medullary collecting ducts. Y. Wang, J.D. 

Klein and J.M. Sands. Emory Univ. 

D634 1024.21 Ethnic differences in renal water handling: 

a thirsty phenotype L. Bankir, J.H. Pratt and A.B. Weder. 

INSERM U872, Paris, Indiana Univ. Sch. of Med. and Univ. of 

Michigan. 

D635 1024.22 Generation and phenotype of a transgenic 

knockout mouse lacking the urea transporters UT-A2 and UT- 

B. B. Yang, T. Lei, L. Bankir and H. Zhou. INSERM Unite 872, 

France, Peking Univ., People’s Republic of China. 

D636 1024.23 Primary cilium is required for vasopressinmediated 

aquaporin-2 trafficking. T. Saigusa, P.D. Bell and 

R.J. Kolb. Med. Univ. of South Carolina and VA Med. Ctr. 

D637 1024.24 Time course of urinary concentrating defect 

in vitamin D-induced hypercalcemic rats. S. Khositseth, S. 

Sriwong and P. Uawithya. Fac. of Med., Thammasat Univ. and 

Fac. of Med., Mahidol Univ., Thailand. 

D638 1024.25 Long-term dDAVP increases the expression of 

urea transporters and ER stress pathway genes in kidneys of 

mice with urinary concentrating defect. Q. Cai, S. Nelson and 

H.L. Brooks. Univ. of Arizona. 

D639 1024.26 Two-compartment model of rat renal inner 

medullary vasculature: relevance to countercurrent exchange 

and medullary blood flow. T.L. Pannabecker, J. Kim, J. Yuan, B. 

Hoopes, C. Laufenberg and Z. Sadideen. Univ. of Arizona. 

D640 1024.27 Hyperosmolarity stimulates heat shock protein 

40 and 70 interaction with UT-A1 urea transporter. G. Chen, X. 

Feng, O. Fröhlich, Y. Yang, J.D. Klein and J.M. Sands. Emory 

Univ. 

D641 1024.28 Urinary excretion of angiotensinogen in male 

and female Sprague Dawley rats during angiotensin II infusion 

and high salt diet. V.F. Rands, C. Byrd, D.M. Seth, H. Kobori 

and M.C. Prieto. Tulane Univ. 

D642 1024.29 Sex steroids and renal protein excretion in 

mice: the importance of testosterone. A. Rouch, N. White, J. 

Burke, N. Gadd and L. Kudo. Oklahoma State Univ. Ctr. for 

Hlth. Sci. 

t 

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321

Physiology 

D643 1024.30 In vivo determination of the renal activity of the 

epithelial sodium channel using benzamil natriuresis in male 

and female mice infused with angiotensin II. L. Li, S. Tiwari, 

S. Mulroney, K. Sandberg and C.M. Ecelbarger. Georgetown 

Univ. 

D644 1024.31 Sex and racial background influence angiotensin 

peptide metabolism in young adults. T.M. Gwathmey, H.A. 

Shaltout, P.A. Nixon, J.C. Rose, L.K. Washburn and M.C. 

Chappell. Wake Forest Univ. Sch. of Med. and Wake Forest 

Univ. 

D645 1024.32 Inhibition of estradiol synthesis attenuates 

diabetic renal disease in male streptozotocin-induced diabetic 

rats. M.B. Manigrasso, D.C. Marbury, R.T. Sawyer, E.R. Flynn 

and C. Maric. Univ. of Mississippi Med. Ctr. 

D646 1024.33 Blood pressure independent sexual dimorphism 

in proteinuric response to high salt intake in Sprague-Dawley 

rats. C.A. Byrd, V.F. Rands, M.C. Prieto and L.G. Navar. 

Tulane Univ. 

1025. Water and Electrolyte Homeostasis 

Poster 



D647 1025.1 Improved renal tubular function detected 

by magnetic resonance imaging after revascularization of 

experimental renal artery stenosis. L. Warner, J.R. Woollard, 

J.D. Glockner, J.D. Krier, X.Y. Zhu, S. Textor and L.O. Lerman. 

Mayo Clin. 

D648 1025.2 Bioimpedance spectroscopy for the estimation 

of body fluid volumes in mice. M.E. Chapman, D. Kohan, C. 

Plato and L. Hu. Univ. of Utah and Gilead, Westminster, CO. 

D649 1025.3 Enhanced oxidative and carbonyl stress 

predicts salt sensitivity in obese young adults. T. Mori, A. 

Kawamata, T. Hosoya, Y. Yoneki, E. Mitui, Y. Hasegawa, 

M. Ohta, M. Ito, H. Sato, S. Kabayama, S. Ito and W. Hida. 

Tohoku Univ., Tohoku Univ. Grad. Sch. of Med. and Trim Med. 

Inst., Sendai, Japan. 

D650 1025.4 In vivo inhibition of renal heme oxygenase-1 

with an imidazole-dioxolane inhibitor, QC-13. E. Csongradi, T. 

Vera and D.E. Stec. Univ. of Mississippi Med. Ctr. 

D651 1025.5 Salt intake sensitization and hypothalamic 

expression of genes related to the renin-angiotensin system. 

D.T.B. Pereira-Derderian, S. Chiavegatto, J.V. Menani and 

L.A. De Luca, Jr. UNESP, Araraquara, Brazil, Univ. of North 

Texas Hlth. Sci. Ctr. and USP, São Paulo. 

D652 1025.6 Hypertension in response to agonistic 

autoantibodies to the angiotensin II type I receptor: role of 

reactive oxygen species. B. LaMarca, M. Parrish, A. Weimer, 

M. Arany, K. Cockrell and R. Dechend. Univ. of Mississippi 

Med. Ctr. and HELIOS Clin., Berlin. 

D653 1025.7 The voltage-operated potassium channel Kv1.1 

as new player in renal magnesium handling. B. Glaudemans, J. 

van der Wijst, R. Scola, P. Lorenzoni, A. Heister, A. van der 

Kemp, N. Knoers, J. Hoenderop and R. Bindels. Nijmegen 

Ctr. for Molec. Life Sci., Parana Fed. Univ., Brazil and Inst. for 

Genet. and Metab. Dis., Nijmegen, Netherlands. 

D654 1025.8 Timing of placental ischemia is important in the 

development of an angiogenic imbalance during pregnancy. 

E.L.B. Soldner, B.K. Johnson and J.S. Gilbert. Univ. of 

Minnesota Med. Sch.-Duluth. 

D655 1025.9 Dahl salt-sensitive rats on a high-fat diet 

develop hypertension and enhanced constriction to angiotensin 

II without changing endothelial-dependent vasorelaxation. 

F.T. Spradley, D.M. Pollock and J.S. Pollock. Med. Col. of 

Georgia. 

D656 1025.10 Diabetic natriuresis is due to the loss of insulin 

dependent proximal tubular sodium reabsorption. M. Manhiani, 

T.A. Sheppard, A.J. Allen, M.T. Cormican and M.W. Brands. 

Med. Col. of Georgia. 

D657 1025.11 Moderate hyperbilirubinemia improves renal 

hemodynamics in angiotensin II-dependent hypertension. D.E. 

Stec and T. Vera. Univ. of Mississippi Med. Ctr. 

D658 1025.12 Activation of P2Y1 purinergic receptors 

induced calcium influx in rat supraoptic neurons through stretch 

inactivated cation channels. Z. Song. Univ of Colorado Denver 

Hlth. Sci. Ctr., Aurora. 

D659 

1025.13 Central mineralocorticoid receptor blockade 

reduces sodium appetite in rats: new evidence for an old effect. S. 

Formenti, G. Schoorlemmer, J.V. Menani and E. Colombari. 

UNIFESP, São Paulo and FOAR-UNESP, Araraquara, Brazil. 

D660 

1025.14 Peripheral versus central administration of 

NaCl differently modulates vasopressin secretion through the 

regulation of PVN Gaq sub-unit proteins. D.R. Kapusta and 

R.D. Wainford. LSU Hlth. Sci. Ctr., New Orleans. 

D661 

1025.15 Brain-derived neutrotrophic factor binding 

is required for its receptor TrkB activation in the supraoptic 

nuclei following dehydration in the rat. F.R. Carreno and J.T. 

Cunningham. Univ. of North Texas Hlth. Sci. Ctr. 

D662 

1025.16 Sham rehydration contributes to increased Fos 

staining in the hindbrain after water deprivation in the rat. J.T. 

Little, W.D. Knight, L.L. Ji, H. Gottlieb and J.T. Cunningham. 

Univ. of North Texas Hlth. Sci. Ctr. and Feik Sch. of Pharm., 

Univ. of Incarnate Word, TX. 

D663 

1025.17 Fyn kinase-TrkB receptor-NMDAR2B glutamate 

receptor subunit (NR2B) physical interaction is increased 

in the supraoptic nuclei following dehydration in the rat. A.A. 

McGovern, F.R. Carreno and J.T. Cunningham. Univ. of 

North Texas Hlth. Sci. Ctr. 

D664 

1025.18 Oropharyngeal regulation of urine output and 

cardiovascular function in rats with osmotic stimulation by 

sham ingestion. H.B. Gottlieb, D.W. Knight, L. Ji and J.T. 

Cunningham. Univ. of Incarnate Word Feik Sch. of Pharm. and 


D665 


1025.19 Blockade of T-type calcium channel with 

R(-) efonidipine ameliorates the renal ischemia induced by 

angiotensin II in Sprague-Dawley rats. T. Mori, C. Hu, Q. Guo, 

Y. Yoneki, T. Nakamichi and S. Ito. Tohoku Univ. Grad. Sch. of 

Med., Japan. 

D666 1025.20 Expression of dynamin and nitric oxide synthase 

isoforms in rat and mouse collecting ducts. K.A. Hyndman, E. 

Kim and J.S. Pollock. Med. Col. of Georgia. 

D667 1025.21 Ion translocation via the transmembrane 

domain 5 in the sodium/bicarbonate transporter NBCe1. S. Lee 

and I. Choi. Emory Univ. Sch. of Med. 

D668 1025.22 Expected hypotension in the Af17 knockout 

mouse. W. Zhang. Univ. of Texas Med. Sch. at Houston. 

322

tuesday 

1026. Control of Breathing: Chemoreception 

Poster 



D669 1026.1 Role of pH regulatory components in the 

transduction response of central CO 2 

chemoreceptors. J.M. 

Cordovez, C. Clausen, L.C. Moore and I.C. Solomon. Stony 

Brook Univ. and Univ. of los Andes, Colombia. 

D670 1026.2 Connexin 26 is responsible for ATP release 

underlying central CO 2 

chemosensitivity. R.T.R. Huckstepp, 

R.C. Eason, R. id Bihi, N. Dicke, K. Willecke, K.M. Spyer, 

A.V. Gourine and N. Dale. Warwick Univ., U.K., Univ. of Bonn 

and University Col. London. 

D671 1026.3 The bullfrog neuroventilatory response to 

hypercapnia is unaffected by cannabinergic potentiation. N.B. 

Bajada, C.M. Brundage and B.E. Taylor. Univ. of Alaska 

Fairbanks. 

D672 1026.4 Leptin deficiency impairs hypercapnic 

ventilatory responses independently of changes in body weight. 

M. Bassi, J.M. do Carmo, S. Hamza and J.E. Hall. Univ. of 

Mississippi Med. Ctr. 

D673 1026.5 Modulation of neuroventilation and central 

chemosensitivity: serotonergic and hypocretinergic effects. 

A.E. Corcoran, G.B. Richerson and M.B. Harris. Dartmouth 

Med. Sch., Yale Univ. and Univ. of Alaska Fairbanks. 

D674 1026.6 Chronic administration of fluoxetine markedly 

attenuates the hypercapnic ventilatory response in urethaneanesthetized 

female mice. T.A. Bale and I.C. Solomon. Stony 

Brook Univ. 

D675 1026.7 Raphe serotonin neurons: characteristics of 

central chemoreceptors in situ. K.E. Iceman, A.E. Corcoran 

and M.B. Harris. Univ. of Alaska Fairbanks and Dartmouth 

Med. Sch. 

D676 1026.8 The orexin receptor 1 in the rostral medullary 

raphe contributes to the hypercapnic chemoreflex in 

wakefulness, during the dark (active) period of the diurnal 

cycle. M.B. Dias, A. Li and E.E. Nattie. Dartmouth Med. Sch. 

D677 1026.9 Effects of bilateral inhibition of retrotrapezoid 

nucleus on breathing in conscious rats. A.C. Takakura, T.S. 

Moreira, P.M. De Paula, J.V. Menani and E. Colombari. São 

Paulo State Univ., Araraquara, Univ. of São Paulo and Fed. 

Univ. of São Paulo. 

D678 1026.10 Photostimulation of channelrhodopsintransfected 

rostral medullary Phox2b-expressing neurons 

activates breathing in unaesthetized rats. R. Kanbar, R.L. 

Stornetta, S.J. Lewis and P.G. Guyenet. Univ. of Virginia. 

D679 1026.11 Changes on respiratory chemosensitivity after 

vagotomy in rats. T.S. Moreira and A.C. Takakura. Univ. of São 

Paulo and São Paulo State Univ., Araraquara. 

D680 1026.12 Focal acidification of the caudal ventrolateral 

medulla (Loeschcke’s area) increases ventilation during 

wakefulness but not in sleep. G.S.F. Silva, A. Li and E. Nattie. 

Dartmouth Med. Sch. 

D681 

1026.13 NK-1 receptors expressing neurons in the locus 

coeruleus play a role in cardiorespiratory response to CO 2 

. L.H. 

Gargaglioni, D. de Carvalho, K.C. Bicego, G.S. Ferreira da 

Silva, O.W. Castro and N. Garcia-Cairasco. FCAVJ-São Paulo 

State Univ. and FMRP-Univ. of São Paulo, Ribeirão Preto. 

pHysiology 

D682 1026.14 Further evidence of redox modulation of 

neurons in a CO 2 

-chemosensitive area: normobaric hyperoxia 

(95%O 2 

) stimulates CO 2 

-chemosensitive and –insensitive 

neurons in the solitary comple. M.P. Matott, C.S. Landon, 

R.W. Putnam and J.B. Dean. Univ. of South Florida and Wright 

State Univ. 

D683 1026.15 The effect of hypoxia on the ventilatory and 

cerebral blood flow responses to CO 2 

. A. Battisti, J. Fisher 

and J. Duffin. Univ. of Toronto and Toronto Gen. Hosp. 

D684 1026.16 Oxygen transport from air to cell: the impact of 

age. M. Amann, D.W. Wray, C. Wary, A. Monnet, P.G. Carlier 

and R.S. Richardson. Univ. of Utah, Pitié-Salpêtrière Univ. 

Hosp., Paris and VA Med. Ctr., Salt Lake City. 

D685 1026.17 Baroreflex unloading blunts chemoreceptor 

sensitivity in postural tachycardia syndrome. I. Taneja, D.A. 

Clarke, M.S. Medow, A.J. Ocon and J.M. Stewart. New York 

Med. Col. 

D686 1026.18 Prolonged maintenance of cardiopulmonary 

stability in mice: strain-specific ventilatory requirements. L. 

Pichard, E. Kostuk, P. Pashai, R. Fitzgerald and M. Shirahata. 

Johns Hopkins Univ. 

D687 1026.19 Murine carotid body responses to hypoxia: 

in vivo carotid sinus nerve recordings in the DBA/2J and A/J 

strains. L. Pichard, F. Sgambati, E. Kostuk, P. Bashai, R. 

Fitzgerald and M. Shirahata. Johns Hopkins Univ. 

D688 1026.20 Global knockout of AMP-activated protein 

kinase alpha subunits attenuates the hypoxic ventilatory 

response in mice. C.N. Wyatt, H.L. Jordan, B.L. Barr, B. 

Viollet, C. Peers, D.G. Hardie and A.M. Evans. Wright State 

Univ., INSERM, Paris, Leeds Univ., Univ. of Dundee and Univ. 

of Edinburgh. 

D689 1026.21 In vivo pharmacological alterations of murine 

carotid body responses to hypoxia: the role of BK channels 

in hypoxic sensitivity. L. Pichard, F. Sgambati, E. Kostuk, 

P. Bashai, R. Fitzgerald and M. Shirahata. Johns Hopkins 

Univ. 

D690 1026.22 Hypoxia versus hydrogen sulfide acting at the 

carotid body and elsewhere systemically. R.S. Fitzgerald, M. 

Shirahata and E. Kostuk. Johns Hopkins Univ. 

D691 1026.23 Effects of HIF-1a gene deletion in respiratory 

centers on ventilatory acclimatization to hypoxia. A. Go, Z. Fu, 

R.S. Johnson and F.L. Powell. UCSD. 

D692 1026.24 The effect of chronic ibuprofen treatment on 

ventilatory acclimatization to hypoxia. D. Popa, Z. Fu and F. 

Powell. UCSD. 

D693 1026.25 Chronic sustained hypoxia reduces neuronal 

excitability in 2nd-order neurons of peripheral chemoreceptors 

in the NTS. W. Zhang and S. Mifflin. Univ. of North Texas Hlth. 

Sci. Ctr. at Fort Worth. 

D694 1026.26 Activation of adenosine A2A receptor 

on GABAergic inputs to 2nd-order neurons of peripheral 

chemoreceptors in the NTS. W. Zhang and S.W. Mifflin. Univ. 

of North Texas Hlth. Sci. Ctr. at Fort Worth. 

D695 1026.27 Developmental regulation of glucosensing in 

rat adrenomedullary chromaffin cells. S.J. Livermore, N.A. 

Piskuric, J.A. Buttigieg and C.A. Nurse. McMaster Univ., 

Canada and Toronto Western Hosp. 

D696 1026.28 Intermittent hypoxia enhances chemical 

sensitivity of pulmonary C fibers in rats: role of reactive oxygen 

species. M-Y. Shen, Y-L. Luo and C.J. Lai. Tzu Chi Univ., 

Taiwan. 

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Physiology 

D697 1026.29 Fentanyl turns pulmonary C-fiber-mediated 

rapid shallow breathing into an apnea in anesthetized rats. Z. 

Zhang, C. Zhang, M. Zhou and F. Xu. Lovelace Resp. Res. 

Inst., Albuquerque. 

D698 1026.30 Heavy metals zinc, cadmium and copper 

stimulate pulmonary C-fibers via direct activation of TRPA1. Q. 

Gu and R-L. Lin. Univ. of Kentucky Med. Ctr. 


D699 1026.31 Modulation of acute hypoxia on canonical 

transient receptor potential channel 3. Q. Yang, J-H. Huang, 

X-Q. Yao and G-W. He. Chinese Univ. of Hong Kong, Nankai 

Univ & TEDA Cardiovasc Hosp, Tianjin, People’s Republic of 

China and Providence Heart & Vasc. Inst., Oregon Hlth. & Sci. 

Univ. 

Join Us Next Year! 

Experimental Biology 2011 

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For further information: 

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