SUNDAY, APRIL 10 Across Societies â Experimental Biology
SUNDAY, APRIL 10 Across Societies â Experimental Biology
SUNDAY, APRIL 10 Across Societies â Experimental Biology
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<strong>SUNDAY</strong>ANATOMY<strong>SUNDAY</strong>, <strong>APRIL</strong> <strong>10</strong><strong>Across</strong> <strong>Societies</strong> – <strong>Experimental</strong> <strong>Biology</strong>480. TEACHING, LEARNING AND TESTING IN THEBIOLOGICAL AND BIOMEDICAL SCIENCES IPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCEducationPresentation time: 12:30 PM-2:30 PMRecognizing that techniques and issues related to teachingand the use of computers in research and teaching cross allbiomedical disciplines, <strong>Experimental</strong> <strong>Biology</strong> 2011 has combinededucation posters from all participating societies. Please note:Posters are on display Sunday through Tuesday. Presentationtime is for Sunday only.T12 480.1 Engaging biochemistry majors: a semesterlong inquiry-based project on GAPDH. G. Temple, C. Wright,S. Gabriel and K. Backstrand. Viterbo Univ., WI.T13 480.2 The CReST project: connecting researchers,students and teachers through modeling T. Herman, M.Franzen, S. Colton and M. Hoelzer. Milwaukee Sch. ofEngin.T14 480.3 Detecting green fl uorescent proteindenaturation with household chemicals using a UV light pen:a pilot experiment for high school curricula. L.G. West, L.M.Sherwood, S-P. Bergeron and P. DeLaLuz. Lee Univ., TN.T15 480.4 Examination of nutritional policy as a heuristicmethod in the biochemistry course. R. Feinman and W.Pogozelski. SUNY Downstate Med. Ctr. and SUNY Geneseo.T16 480.5 Dietary carbohydrate restriction in theundergraduate and medical school biochemistry course. W.Pogozelski and R. Feinman. SUNY Geneseo and SUNYDownstate Med. Ctr.T17 480.6 Biochemistry students’ understanding ofenzyme-substrate interactions. K. Linenberger and S. LoweryBretz. Miami Univ.T18 480.7 An online graduate pharmacology course fordoctor of nurse anesthesia practice students. L.S. Dieckmann.Texas Wesleyan Univ.T19 480.8 Quantitative ion channel, receptor dynamics,and systems biology simulations for pharmacology graduateeducation R.W. MIllard, T. Kirley, R. Kasturi and H-S. Wang.Univ. of Cincinnati.T20 480.9 GRAD-PREP: new training program designedto increase entry of disadvantaged groups into graduateprograms in the biomedical sciences. M. Key, C. Shingledeckerand M. Morris. Wright State Univ. Boonshoft Sch. of Med.T21 480.<strong>10</strong> Base pair: early biomedical researchmentorship impacts health career outcomes. R.W. Rockholdand D.C. Sullivan. Univ. of Mississippi Med. Ctr.T22 480.11 Interactive learning of autonomic nervoussystem pharmacology: integration of team-based learningand simulation. A.A. Lerant, R.W. Rockhold, J. Orledge, W.J.Phillips and R. Kramer. Univ. of Mississippi Med. Ctr.481. TEACHING, LEARNING AND TESTING IN THEBIOLOGICAL AND BIOMEDICAL SCIENCES IIPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCEducationPresentation time: 1:30 PM-3:30 PMRecognizing that techniques and issues related to teachingand the use of computers in research and teaching cross allbiomedical disciplines, <strong>Experimental</strong> <strong>Biology</strong> 2011 has combinededucation posters from all participating societies. Please note:Posters are on display Sunday through Tuesday. Presentationtime is for Sunday only.T23 481.1 Using a classic research article to teach andengage students in an introductory biology course. J. Krontiris-Litowitz. Youngstown State Univ.T24 481.2 Using manipulatives to help students buildconceptual frameworks in science. J. Krontiris-Litowitz.Youngstown State Univ.T25 481.3 Neuron simulation: allowing students tovisualize the invisible during the action potential. F.J. B.Bentley, J. Casagrand, K. Perkins and N. Podolefsky. Univ.of Colorado at Boulder.T26 481.4 JSIM and CRM are synergistic for modelingbreath-dependent drift when tidal volume is derived frompulmonary airfl ow measures. N. Pelaez and T.R. Anderson.Purdue Univ. and Univ. of KwaZulu-Natal (Pietermaritzburg),South Africa.T27 481.5 Teaching physiology with the marble game.P.H. Nelson. Benedictine Univ., IL.T28 481.6 The UNSIN Project: exploring the molecularphysiology of sins. F.N. Naji, L. Salci, G. Hoit and P.K.Rangachari. McMaster Univ., Canada.T29 481.7 Mechanic hearing system model. J.E. Macías-Garza, L. Castillo-Hernández, A. Quintanar-Stephano, J.Martínez-Hernández, R. Salas-Vazquez, M. Esparza-Reyesand R. Ramírez-Ruiz. Autonomous Univ. of Aguascalientes,Mexico.T30 481.8 Using a human patient simulator with 1st yearmedical students to facilitate learning of cardiovascular functioncurves. D.M. Harris and K. Ryan. Drexel Univ. Col. of Med.T31 481.9 Demonstrating the control of ventilation via asimulation-enhanced physiology curriculum for undergraduates.J.R. Harris, R.J. Helyer, E. Lloyd and S.J. W. Lisney. Sch. ofPhysiol. and Pharmacol., Univ. of Bristol.T32 481.<strong>10</strong> Advanced physiologic simulations within themedical curriculum demand specifi c sequencing and curricularcoordination. J. Cendan and T. Johnson. Univ. of CentralFlorida Col. of Med.T33 481.11 Anatomy’s next top model for “model”physiologists. S.E. DiCarlo, D.J. Hermiz, D.J. O’Sullivan, S.Krishnan, H.R. A. Janbaih and H.L. Lujan. Wayne State Univ.Sch. of Med.SUN133
<strong>SUNDAY</strong>485. DEVELOPMENT AND GROWTH: CRANIOFACIALPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:30 PM-2:00 PMC17 485.1 Early gene interactions that discriminate amongthe four ectodermal domains in the embryonic head. M.C.Peterson, J. Xu, K.M. Neilson, S.A. Moody and C.H. Sullivan.Penn State, George Washington Univ. and Grinnell Col., IA.C18 485.2 Deciphering microarray data provides insightinto intramembranous bone induction and patterning — buthow deep is it buried!. J. Jabalee and T.A. Franz-Odendaal.Mount Saint Vincent Univ., Canada.486. DEVELOPMENT AND GROWTH: GENE ANDPROTEIN EXPRESSIONPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:30 PM-2:00 PMC19 486.1 Characterizing the nature of the Xst199mutation and the normal function of the TANGO1 protein introphoblast cells. A.C. Moore and A. Sutherland. Univ. ofVirginia.C20 486.2 Claudin expression in embryonic kidney tubules.I.R. Gupta, H. Khairallah, A. Baumholtz, M.M. Collins, J. ElAndalousi and A.K. Ryan. McGill Univ. Hlth. Ctr.C21 486.3 Zebrafi sh as a vertebrate model of ENOSF1function. S.M. Finckbeiner, P-J. Ko, K. Bishop, R. Sood, K.Gross, B. Dolnick, J. Sufrin and P. Liu. NHGRI, NIH andRoswell Park Cancer Inst.C22 486.4 Identifi cation of Pitx2c interaction partners.A.K. Ryan and D. Siontas. McGill Univ.487. DEVELOPMENT AND GROWTH: LIMBSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:30 PM-2:00 PMC23 487.1 The relationship between infl ammation andregeneration in larval Xenopus limbs. A.L. Mescher, A. Neffand M. King. Indiana Univ. Sch. of Med., Bloomington.C24 487.2 Disparate conservation of gene expression inLMX1B-directed limb dorsalization. M. Estes, J.M. Feenstra,C.U. Pira and K.C. Oberg. Loma Linda Univ.C25 487.3 Upregulation of Lef1 during Fgf2 mediatedinduction of Shh expression. G.L. Mattison, E.D. Steinman,C.U. Pira and K.C. Oberg. Loma Linda Univ.C26 487.4 Defi ning the mechanism of limb regeneration:a potential novel role for BAMBI in mediating Fgf-induced Shhupregulation. E.D. Steinman, G.L. Mattison, C.U. Pira andK.C. Oberg. Loma Linda Univ.C27 487.5 Sonic hedgehog promotes patternedregeneration in OZD mutants. D.G. Rudisaile, R.O. Woods,C.U. Pira, J.F. Fallon and K.C. Oberg. Loma Linda Univ. andUniv. of Wisconsin-Madison.488. BONES, CARTILAGE AND TEETH: EXERCISE,BIOMECHANICS, BIOENGINEERINGPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:30 PM-2:00 PMC28 488.1 The effects of manipulating the frequency andmagnitude of mastication on systemic skeletal robusticity inmice. L.E. Copes, A. Oldak, M.R. Brown and K. Whitmore.Sch. of Human Evol. and Soc. Change, Arizona State Univ.C29 488.2 The effect of exercise on the musculature andcurvature of the spine in dystrophin-defi cient mice. E. Simons,D. Brereton and J.H. Plochocki. Midwestern Univ., AZ.C30 488.3 Z joint gapping as assessed by piezoelectricaccelerometry and MRI. G. Cramer, K. Ross, P.K. Raju,J. Cambron, J. Cantu, J. Dexheimer, P. Bora, S. Selby, A.Habeck, D. Gregerson and R. McKinnis. Natl. Univ. of Hlth.Sci., IL, Canadian Mem. Chiropractic Col., Toronto and AuburnUniv.C31 488.4 Pelvic kinematics between healthy womenand women with ACL reconstruction during a drop jump. M.G.Rosario, A. Ortiz and M. Lopez. Univ. of Puerto Rico Med. Sci.Campus, Sch. of Hlth. Professions and Sch. of Med.C32 488.5 Force production during a counter movementjump in subjects with Parkinson disease. T. Haacker, K.B.Foreman, P.C. LaStayo, R.L. Marcus and L.E. Dibble. Univ.of Utah.C33 488.6 The effects of fatigue and gender on ankleligament laxity. K. Silke, J. Hertel and R. Wunderlich. JamesMadison Univ. and Univ. of Virginia.C34 488.7 Voluntary exercise, spontaneous physicalactivity, and systemic skeletal robusticity in high endurancerunningmice L.E. Copes, H. Schutz, E.M. Dlugsoz and T.Garland, Jr. Sch. of Human Evol. and Soc. Change, ArizonaState Univ., Univ. of California, Riverside and Cal Poly StateUniv., San Luis Obispo.C35 488.8 Regional variation in canal volume of the humantibial cortex. N.A. Hampson, K.J. Jepsen, S.R. Kalidindi, G.F.Duarte and H.M. Goldman. Drexel Univ., Mount Sinai Sch. ofMed. and Drexel Univ. Col. of Med.489. BONES, CARTILAGE AND TEETH: EVOLUTIONAND ANTHROPOLOGYPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:30 PM-2:00 PMANATOMYC36 489.1 Morphology of invasion: 3D cranial morphologyof Florida’s Nile monitor population. S. Macks, M.B. Meers, T.Campbell and C. McHenry. Univ. of Tampa and Monash Univ.Sch. of Biomed. Sci., Australia.C37 489.2 Ontogenetic changes in the microarchitectureof sutures in the American alligator (Alligator mississippiensis).U. Zapata, S. Liu, J. Sun, R.M. Elsey and Q. Wang. MercerUniv. Med. Sch., Eafi t Univ., Colombia, Indiana Univ. Sch. ofDent. and Louisiana Dept. of Wildlife and Fisheries, GrandChenier.135SUN
ANATOMYC38 489.3 The ontogeny of calvarial suture fusion inHominoidea and Macaca mulatta. J.J. Cray, Jr., G.M. Cooper,M.P. Mooney and M.I. Siegel. Univ. of Pittsburgh.C39 489.4 Population and sex-specifi c variation in modernhuman browridge and chin morphologies. H.M. Garvin. JohnsHopkins Univ. Sch. of Med.C40 489.5 Modeling the functional morphologic relationshipbetween orbital hypertrophy and choanal dimensions: a 3Dgeometric morphometric study of the owl monkey. D. Yang,A.S. Pagano and J.T. Laitman. Mount Sinai Sch. of Med.C41 489.6 Perinatal orbitonasal morphology of primates.T.D. Smith, A.E. Bruening, M.A. Holmes, S.J. Rehorek andV.B. DeLeon. Slippery Rock Univ. and Johns Hopkins Univ.Sch. of Med.C42 489.7 Functional integration of the bony orbits andpiriform aperture during facial growth in humans. E. Wang, A.S.Pagano and J.T. Laitman. Mount Sinai Sch. of Med.C43 489.8 Quantifying degree of mineralization in ribcortical bone of immature human archaeological remains. C.D.Eleazer. Univ. of Tennessee, Knoxville.490. BONES, CARTILAGE AND TEETH: ANATOMYAND MORPHOLOGYPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:30 PM-2:00 PMC44 490.1 The origin of the cyamella – the poplitealsesamoid. T. Ghosh. King Faisal Univ., Saudi Arabia.C45 490.2 Clinically oriented morphometric study of themedial and lateral menisci of the knee joint in South Indianadult cadavers. B. V. Murlimanju and N. Nair. Manipal Univ.,India.C46 490.3 Histomorphometric analysis of surgicallyinduced versus naturally occurring murine OA. M.A. McNulty,R.F. Loeser, C.M. Ferguson, M.F. Callahan and C.S. Carlson.Rush Univ. Med. Ctr., Univ. of Minnesota, St. Paul and WakeForest Univ. Sch. of Med.C47 490.4 Morphometrical analysis of different humerussegments of South Indian population. M. S. Somesh and S. K.Kasturba Med. Col., India.C48 490.5 Ipsilateral versus contralateral anisomeliabetween the upper and lower limbs. S. Baral, T. Adar, A.S.Pagano and S. Marquez. SUNY Downstate Med. Ctr. andMount Sinai Sch. of Med.C49 490.6 Anatomy of foramina on the zygomatic bone:its clinical signifi cance. A. Krishnamurthy, R. Sadashiv andM.S. Somesh. Kasturba Med. Col., Manipal Univ., India.C50 490.7 Morphological and morphometric study of thevermian fossa in South Indian human adult skulls. G.K. Chettiarand B.V. Muralimanju. Kasturba Med. Col., India.C51 490.8 Growth change and functional morphology ofthe osseous choanal boundaries of humans: a 3D geometricmorphometric study. A.S. Pagano, E. Wang and J.T. Laitman.Mount Sinai Sch. of Med.491. BONES, CARTILAGE AND TEETH:CRANIOFACIALPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:30 PM-2:00 PMC52 491.1 An anatomical study of the alveolar process inthe human maxilla and its relation to the maxillary sinus usingµ-CT: to facilitate successful dental implants. E. Israel, K.A.Galil and T.D. Wilson. Univ. of Western Ontario.C53 491.2 Palatal rugoscopy in Egyptian and Libyanpopulations. S.M. Tayel, A.K. Al-hrabi, A.M. Atteya and S.S.Tayel. Fac. of Med., Alexandria Univ., Egypt and Fac. of Med.Sci., Al-Jabal Al-Gharbi Univ., Libya.C54 491.3 Investigation of the impacts oftemporomandibular joint pathology and antemortem tooth losson three-dimensional craniofacial shape. L. Barket and H.F.Smith. Arizona Col. of Osteo. Med., Midwestern Univ. andArizona State Univ.C55 491.4 Expression of hypoxia inducible factor mRNAin human gingival tissue. I. Sato, Y. Miwa and K. Shimada.Nippon Dent. Univ. and Kagoshima Univ., Japan.C56 491.5 Characterization of the inner enamel epitheliumand odontoblasts during the secretory and maturation stagesin newts’ teeth development. Y. Miwa, I. Sato and K. Shimada.Nippon Dent. Univ. and Kagoshima Univ., Japan.492. BONES, CARTILAGE AND TEETH: MOLECULARMECHANISMSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:30 PM-2:00 PM<strong>SUNDAY</strong>C57 492.1 Effects of BMP signaling on osteogenicdifferentiation and tooth eruption. S.A. Hafez, S. Yao and G.E.Wise. LSU Sch. of Vet. Med.C58 492.2 BMP-2 induces VEGF expression in culturedhuman osteoblast: a possible role for reactive oxygen speciesand HIF-1α. S. Akeel, A. El-Awady, M. El-Salanty, M. Sharawyand M. Al-Shabrawey. Med. Col. of Georgia.C59 492.3 The effects of a serotonin 5-HT2b receptoragonist on bone, cartilage, and cardiac growth in heterozygousOI mice J.H. Plochocki, D. Blaty and R. Ho. Midwestern Univ.,AZ.C60 492.4 Connective tissue growth factor ablation impairsosteogenesis and bone modeling. A.G. Lambi, R.A. Pixley,F.F. Safadi and S.N. Popoff. Temple Univ. Sch. of Med.C61 492.5 The role of cannabinoid receptors in boneremodeling in a CB1/2 double knockout mouse. R.A. Pixley,F.E. Del Carpio-Cano, J.Y. Belcher, H. Hendesi, C.S. Popoff,L. Le, R. Razmpour, A. Zimmer, M.E. Abood, F.F. Safadi andS.N. Popoff. Temple Univ.C62 492.6 All nine transmembrane adenylyl cyclaseisoforms are temporally expressed in rat articular chondrocytes.I. Memon, K. Khan, S. Siddiqui, S. Perveen and M. Ishaq.Aga Khan Univ., Pakistan, Kuwait Univ. and Sir Syed Col. ofMed. Sci., Pakistan.136
<strong>SUNDAY</strong>C63 492.7 Expression of Klf5 and MMP9 is associatedwith cartilage degradation and vascular invasion in humanosteoarthritis. H. Li, S-b. Miao, F. Wang, D-c. Shao and B-c.Chen. Third Hosp., Hebei Med. Univ., People’s Republic ofChina.C64 492.8 Failed bone homeostasis in the op rat is notdue to a mutation in the coding region of the Prss34 gene. D.E.Dobbins. Uniformed Svcs. Univ. of Hlth. Sci.C65 492.9 Effect of perlecan/Hspg2 endoplasmic reticulumretention on cellular stress during cartilage development. D.A.Lowe, P.P. Srinivasan and C. Kirn-Safran. Univ. of Delaware.493. ANATOMY EDUCATIONPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:30 PM-2:00 PMC66 493.1 Medical student study skills in anatomy andphysiology: is there a difference? P.R. Husmann and J.B.Barger. Indiana Univ.C67 493.2 An education-focused PhD program in anatomy:early experiences and future challenges. J.J. Brokaw. IndianaUniv. Sch. of Med.C68 493.3 Promoting innovation in anatomical educationthrough interdisciplinary collaboration. M.D. Skinner and D.A.Morton. Univ. of Utah.C69 493.4 The Anatomy Mentor Program: a refl ection ofstudent-directed learning. A.D. Richardson, M.K. Hensley,J.F. Thomas and J.K. Brueckner-Collins. Univ. of KentuckyCol. of Med. and Univ. of Louisville.C70 493.5 The perception of stress associated withcadaveric dissection. R. Ettarh and G.F. Perry. Tulane Univ.Sch. of Med. and University Col. Dublin.C71 493.6 Anatomy of errors in anatomical illustrations. A.Sinav. Trakya Univ. Med. Sch., Turkey.C72 493.7 Art and science of anatomy: hemisection of thehead and neck. A. Koba and L. Johnson. San Francisco StateUniv.C73 493.8 MedStart: a Mount Sinai medical studentprogram to teach East Harlem middle school students anatomy.S. Zuckerman, R. Bhattacharya, E. Chu, M. Schneiderman,S. Factor and J.T. Laitman. Mount Sinai Sch. of Med.494. ANATOMY EDUCATION: CLINICAL-BASEDAPPROACHESPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:30 PM-2:00 PMC74 494.1 Clinical reasoning in early basic sciencecourses. R.E. Elizondo Omaña, J.A. Morales Gómez, O.Morquecho Espinoza, J.M. Hinojosa Amaya, E.E. VillarrealSilva and S. Guzmán López. Med. Sch., Autonomous Univ. ofNuevo Leon, Mexico.ANATOMYC75 494.2 Medical student perceptions of the value ofanatomy knowledge and instructional methodologies towardgaining confi dence in clinical skills. J. Wisco, P. Rabedeaux, S.Lerner, C. Byus and P. Wimmers. David Geffen Sch. of Med.at UCLA and UCR/UCLA Thomas Haider Prog. in Biomed. Sci.,Riverside.C76 494.3 The Tutor Guide: a hidden gem in tutorfacilitated,small group, case-based learning in a medicalschool R.W. Clough, N.S. Viscomi, E.C. Niederhoffer andS.L. Shea. SIU Sch. of Med. Carbondale.C77 494.4 Critical thinking and integration of anatomyknowledge through longitudinal patient-based virtual scenariosin a fi rst-year gross anatomy course. S. Aberle, P. Warner, N.Lachman, W. Pawlina, E. Angstman and J. Grande. MayoMed. Sch., Mayo Clin.C78 494.5 Novel teaching assistant-led approach tothe teaching of radiographic imaging in Gross Anatomy. R.E.Accordino, K.H. V. Lau, S.A. Tulin-Silver and K.M. Mak.Mount Sinai Sch. of Med.C79 494.6 Using radiological imaging to improveanatomical relationships in a gross anatomy setting. N.S.Livdahl, P. Caligiuri and D.A. Morton. Univ. of Utah.C80 494.7 Student radiology liaisons facilitate learningradiology during a fi rst year medical school anatomy course. A.Khosla, N. Lachman, J. Barlow, W. Pawlina, B. Bartholmaiand P. Eiken. Mayo Med. Sch.C81 494.8 Using lightly embalmed cadavers for trainingin emergency medicine techniques. R. Splittgerber. Univ. ofAlabama at Birmingham.C82 494.9 Delivering clinical-based anatomy to medicalstudents from a surgeon’s perspective. S. Ullah, A. Bodrogi,O. Cristea, M. Johnson and V. McAlister. Schulich Sch. ofMed., Univ. of Western Ontario.C83 494.<strong>10</strong> Development and testing of an endoscopicanatomy learning tool. M. Johnson, S. Bhattacharyya, M.Johnson, T. Wilson, F. Chan, N. Khanna and J. Gregor. Univ.of Western Ontario and St. Joseph’s Hlth. Ctr. and VictoriaHosp., London, Canada.C84 494.11 Hysterectomy with stage-4 vaginal prolapse ina medical gross anatomy lab: a valuable learning enhancementprovided by anomaly. N.S. Viscomi and R.W. Clough. SouthernIllinois Univ. Carbondale.C85 494.12 A geriatric twist on the anatomy fi rst patientexercise C. Elzie. Univ. of Alabama at Birmingham.C86 494.13 The clinical relevance of teaching the medialline theme of the upper limb to future healthcare professionals.B. Benninger. Oregon Hlth. & Sci. Univ.C87 494.14 Anatomy education for occupational therapystudents: what do they need to know? L.K. Smith, K.B.Foreman, E.M. Cardell and O.R. Addison. Univ. of Utah.C88 494.15 Interactive teaching strategies enhanceinformation retention in gross anatomy for physical therapists.K.B. Bruzzini, J. Weaver and K. Goeke. Maryville Univ., MO.SUN137
BIOCHEMISTRY495. ANATOMY EDUCATION: COMPUTER-ASSISTEDLEARNINGPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:30 PM-2:00 PMC89 495.1 Online learning program for regional anatomy:usage and monitoring through Google Analytics. L. Filgueira,P. Groscurth and L. Slomianka. Univ. of Western Australiaand Univ. of Zurich.C90 495.2 Automated system for on-demand generationof photorealistic structure-specifi c interactive anatomicalreconstructions. M.J. Pescitelli, S. Huntley, S. Landers, E.Theiss, C. Lilagan and M. Doyle. Univ of Illinois at ChicagoCol. of Med., Buonacorsi Fndn., Wheaton and Iomas Res. LLC,Wheaton, IL.C91 495.3 Dyad pedagogy and the application of videoeducation in anatomy. A.D. Blumenberg, V. Trivigno, H. Khanand S. Marquez. SUNY Downstate Med. Ctr.C92 495.4 Creation of a digital atlas for ultrasoundguided regional nerve blocks. K. Milne, M. Johnson and S.Ganapathy. Univ. of Western Ontario.C93 495.5 Interdisciplinary media study of anatomicaleducation via virtual worlds. M.J. Devlin and T.D. Wilson. Univ.of Western Ontario.C94 495.6 Use of a digital 3D brain model as anintermediate step in learning spatial anatomy. D.N. Brewer, S.de Ribaupierre and T.D. Wilson. Univ. of Western Ontario.496. ANATOMY EDUCATION: TEACHING METHODSAND INNOVATIONSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:30 PM-2:00 PMC95 496.1 Texas Tech System for student peer teaching inthe anatomy laboratory. V. Lee and B. Vidic. Texas Tech Univ.Hlth. Sci. Ctr.C96 496.2 Taking successful pilot program to scale:evolution of team-based learning in anatomy program. N.Vasan and D. DeFouw. UMDNJ-New Jersey Med. Sch.C97 496.3 Teaching the millennial generation of medicalstudents. A.R. Severson. Univ. of Minnesota Med. Sch.,Duluth.C98 496.4 Critical thinking in the cadaver lab: determiningthe cadaver’s cause of death. M.T. Bee, J.M. Montante and M.Ottenbreit. Oakland Univ. William Beaumont Sch. of Med. andUniv. of Detroit Mercy.C99 496.5 Boning up in anatomy: engaging learningapproaches. M.T. Bee and G. Grabowski. Oakland Univ.William Beaumont Sch. of Med. and Univ. of Detroit Mercy.C<strong>10</strong>0 496.6 Can virtual anatomy lab be an alternative ofcadaver-based anatomy lab? S. Chowdhury and R. Lovely.St Louis Community Col., Wildwood and Missouri State Univ.C<strong>10</strong>1 496.7 A multi-faceted approach to teachingembryology within an integrated human structure course. G.E.Harmon, W. Pawlina and N. Lachman. Mayo Med. Sch.C<strong>10</strong>2 496.8 Creating virtual fl ashcards in the anatomicalsciences using MemoryLifter technology. V. Lyons and N.McNulty. Dartmouth Med. Sch.C<strong>10</strong>3 496.9 Using podcasting to promote learning ofneuroanatomy. C.A. Webber and J. Tong. Univ. of Alberta.497. ANATOMY EDUCATION: UNDERGRADUATEPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:30 PM-2:00 PM<strong>SUNDAY</strong>C<strong>10</strong>4 497.1 Focused preparation of anatomy and physiologyinstructors for the undergraduate college and university setting.R.A. Crocker. New York Chiropractic Col.C<strong>10</strong>5 497.2 Remediation trends in an undergraduateanatomy course. A.F. Schutte. Indiana Univ.C<strong>10</strong>6 497.3 Incorporating anatomical imaging intoundergraduate anatomy labs. J. Jackson and H. Ali. Univ. ofNorth Dakota.C<strong>10</strong>7 497.4 Research as a transformative learning tool inan undergraduate histology course. M.B. Vaughan. Univ. ofCentral Oklahoma.C<strong>10</strong>8 497.5 The effect of a Clearing of the Way ceremonyon students’ attitudes to dissection. H.D. Nicholson, T. Barrettand H. Martyn. Univ. of Otago, New Zealand.138
<strong>SUNDAY</strong>BIOCHEMISTRYBiochemistry and Molecular <strong>Biology</strong>498. ABERRANT DNA REPAIR, GENOMICINSTABILITY AND CANCERPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB1 498.1 Transcriptional response to loss of RNase H2activity in Saccharomyces cerevisiae. M.E. Arana, R.T. Kerns,P.R. Bushel and T.A. Kunkel. NIEHS, NIH, Research TrianglePark.B2 498.2 Inhibition of DNA helicase activity determinedby SPR. W.M. David, S.M. Kerwin and M.J. Decker. TexasState Univ., San Marcos and Univ. of Texas at Austin.B3 498.3 Polymorphic variants of human DNAglycosylase NEIL2 and lung cancer susceptibility. S. Dey, A.K.Maiti, M.L. Hegde, P.M. Hegde, B. Shen, I. Boldogh, J. Xie, V.Cardenas and T.K. Hazra. Univ. of Texas Med. Branch, City ofHope and Indiana Univ.-Purdue Univ. Indianapolis.B4 498.4 Mitotic analysis as a measure of genomicinstability during the propagation of human pluripotentstem cells. V. Fields, M.J. Riggs and R.R. Rao. VirginiaCommonwealth Univ.B5 498.5 A novel role of RGS6 in oncogenic Ras-inducedcellular transformation. J. Huang, J. Yang, J. Hagen, D. Quelleand R. Fisher. Univ. of Iowa.B6 498.6 Regulation and function of the TAZ transcriptionco-activator. Q. Lei. Sch. of Med., Fudan Univ., People’sRepublic of China.B7 498.7 The role of recombination genes duringtelomere maintenance in telomerase-defi cient tumors andprimary cells. T.A. Morrish, V. Behera, M.A. Strong and C.W.Greider. Johns Hopkins Univ.B8 498.8 Syzgium guineensis extracts display cellspecifi c anticancer properties. A. Nkembo, N.S. Lamango,H. Gokham, L. Ayuk-Takem, R. Duverna, R. Marijani and B.Abonyo. Florida A&M Univ.B9 498.9 Studies on the utilization of a thioaptamer forthe rescue of p53 and its mutants. L.P. Rangel, A. P.D. AnoBom and J.L. Silva. Fed. Univ. of Rio de Janeiro and OswaldoCruz Fndn., Rio de Janeiro.B<strong>10</strong> 498.<strong>10</strong> Homologous recombination independent rolefor BRCA2 in blocking stalled replication fork degradation byMRE11. K. Schlacher, N. Christ and M. Jasin. Mem. Sloan-Kettering Cancer Ctr. and UCLA.B11 498.11 RNA polymerase II CTD-associated DNA repairand recombination. T. Winsor, C. Bennett and A. Greenleaf.Duke Univ.499. DNA DAMAGE SIGNALINGPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB12 499.1 In vitro studies of MutSalpha protein inmismatch excision repair and DNA damage signaling. H. Gengand P. Hsieh. NIDDK, NIH.B13 499.2 Loss of p300 induces a rapid aging phenotypeand blunts ATM-initiated DNA damage response. S. Jain, C.Rodrigues, J. Wei and N.H. Bishopric. Univ. of Miami.500. DNA REPAIR MECHANISMSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB14 500.1 Identifi cation of Escherichia coli processingactivities for covalent topoisomerase-DNA complexes. S. Aedoand Y-C. Tse-Dinh. New York Med. Col.B15 500.2 Dissecting cellular inter-strand crosslink repairpathways through the recruitment kinetics of Fanconi anemiaproteins to localized ICLs. M.A. Bellani, P. Muniandy, M.Paramasivam, A. Smogorzewska, W. Wang, J. de Winterand M.M. Seidman. NIA, NIH, Baltimore, Dana Farber Inst.,Rockefeller Univ. and Free Univ. Med. Ctr., Amsterdam.B16 500.3 Conformational explorations into DNApolymerase X from African swine fever virus in the presenceof oxoG lesions. J. Bogdanovic, Z. Barbati, T. Schlick, K.Arora and B.A. S. Benitez. Marymount Manhattan Col., Univ.of Copenhagen, NYU and Univ. of Michigan.B17 500.4 Developing reporter systems to monitor thestructural dynamics of MutS, a DNA mismatch repair protein C.Doucette, M. Hingorani and F.N. Biro. Wesleyan Univ.B18 500.5 NEIL1’s common interaction peptide acts asdominant negative inhibitor of NEIL1-initiated base excisionrepair of oxidized bases: potential for adjuvant cancer therapy.M.L. Hegde, P.M. Hegde, T.K. Hazra, I. Boldogh and S. Mitra.Univ. of Texas Med. Branch.B19 500.6 Deciphering the origin of multiple substratespecifi city of the repair enzyme, AlkB N. Jayanth, N. Ogiralaand M. Puranik. Natl. Ctr. for Biol. Sci., Bangalore.B20 500.7 A structural hinge in the eukaryotic DNA repairglycosylase, MutY homologue, mediates catalytic activity andinteractions with the Rad9-Rad1-Hus1 checkpoint complex P.J.Luncsford, D-Y. Chang, G. Shi, J. Bernstein, A. Madabushi,D.N. Patterson, A-L. Lu and E.A. Toth. Univ. of Maryland Sch.of Med.B21 500.8 Crystal structure of human thymine DNAglycosylase bound to a DNA substrate analog reveals themolecular basis of specifi city and catalysis. A. Maiti, E.Pozharski and A.C. Drohat. Univ. of Maryland Sch. of Med.and Sch. of Pharm.B22 500.9 APE1/Ref-1: a multi-functional protein thatprotects neurons against amyloid beta toxicity. A.K. Mantha,J.R. Perez-Polo and S. Mitra. Univ. of Texas Med. Branch.B23 500.<strong>10</strong> Molecular clues to alkylating agent-induced celldeath and drug resistance. M. Fried, G-M. Li and F. Odago.Univ. of Kentucky.B24 500.11 E. coli UmuD conformational dynamics inresponse to DNA damage. J. Ollivierre, Q. Huang, D. Budiland P.J. Beuning. Northeastern Univ.B25 500.12 A novel role for the VapB-2 antitoxin ofnontypeable Haemophilus infl uenzae in genomic stabilityfollowing oxidative stress. D. Ren, S.D. Cline, C. Bell III andD.A. Daines. Mercer Univ. Sch. of Med.SUN139
BIOCHEMISTRYB26 500.13 Kinetic analysis of mutant T. aquaticus DNAmismatch repair protein MutS. A. Schwartz. Wesleyan Univ.B27 500.14 Heterodimer formation in the DNA damageresponse protein UmuD. J.L. Sikora, J.N. Ollivierre, S.M.Jensen, T.J. Cipriani and P.J. Beuning. Northeastern Univ.B28 500.15 On the requirements of endowing exonucleaseIII homologs with the additional activity of a DNA uridineendonuclease. K. Tseden. Univ. of Goettingen, Germany.501. RNA POLYMERASE PAUSING ANDELONGATIONPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:25 PM-1:55 PMB29 501.1 Pyrophosphate (PPi) suppression oftranscription elongation as catalyzed by E. coli RNApolymerase is not mediated directly by product inhibition orpyrophosphorolysis. R.S. Johnson, M. Strausbauch and J.K.Carraway. Brody Sch. of Med., East Carolina Univ.B30 501.2 Roles for 19S ATPases in transcriptionalelongation. A.D. Truax and S.F. Greer. Georgia State Univ.502. NUCLEOSOME STRUCTURE AND DYNAMICSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:25 PM-1:55 PMB31 502.1 Thermodynamic stability of histone H3 is anecessary but not suffi cient driving force for its evolutionaryconservation. S. Ramachandran, L. Vogel, B.D. Strahl andN.V. Dokholyan. Univ. of North Carolina at Chapel Hill.503. RNA POLYMERASE II PAUSING AND RELEASEPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:25 PM-1:55 PMB32 503.1 Pol II CTD phosphorylation by P-TEFbinfl uences endotoxin tolerance on paused genes. J. Adamik,K.Z. Q. Wang, A. Su and P.E. Auron. Duquesne Univ.B33 503.2 Mechanism and implication of RNA polymeraseII-capping enzyme assembly. J. Fu, M-H. Suh, P. Meyer and C.Kaplan. Med. Col. of Wisconsin and Texas A&M Univ.504. RNA POLYMERASE STRUCTURE505. TRANSCRIPTIONAL ASSEMBLIES ANDMECHANISMSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:25 PM-1:55 PMB35 505.1 Role of N-terminal domain of Rpo41 in yeastmitochondrial transcription. A.P. Deshpande, S. Paratkar,G-Q. Tang and S.S. Patel. UMDNJ, Piscataway.B36 505.2 Characterization of a putative Trypanosomabrucei transcription factor. R.J. Miller, P. Ogorzalek, A. Sing,K. Whitecavage and J. Palenchar. Villanova Univ.B37 505.3 Sequence-dependent specifi c p53-responseelement interactions direct p53 organization and controltranscription selectivity. Y. Pan and R. Nussinov. SAIC, NCI-Frederick and Tel Aviv Univ.B38 505.4 Different domains of SNAPc subunits closelyinteract with U1 versus U6 snRNA gene promoter sequencesfor differential recruitment of RNA polymerases II and III. W.E.Stumph, Y.S. Kang and M.K. Kim. San Diego State Univ.506. TRANSCRIPTIONAL CONTROL OF GROWTHAND DIFFERENTIATIONPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:25 PM-1:55 PM<strong>SUNDAY</strong>B39 506.1 Changes in gene expression during IMCD3 celldifferentiation. B.N. Abbatiello and D.L. Zies. Univ. of MaryWashington.B40 506.2 Transcription-dependent AID targeting toimmunoglobulin variable regions. Z. Cao, R. Maul and P.Gearhart. NIA, NIH, Baltimore.B41 506.3 Vestigial-like 3 regulates myosin light chain andskeletal α-actin promoters. B.L. M. Cheng, E.D. Moher, A.C. T.Teng, N. Almontashiri, Y. Shi, B. Tam and A.F. R. Stewart.Univ. of Ottawa Heart Inst., Canada.B42 506.4 TAF7 is essential for early embryonic mousedevelopment. A. Gegonne, J. Zhang, G. Wu, J. Zhu, J.Hanson, C. Cultraro, T. Guinter, Z. Yang, K. Hathcock, A.Singer, J. Rodriguez-Canales, L. Tessarollo, S. Mackem, D.Meerzaman, K. Buetow and D.S. Singer. NCI, NIH, Bethesdaand Frederick.B43 506.5 The origin of cardiomyocyte stem cells in heartregeneration of Notophthalmus viridescens. B.P. Kemp, S.K.Sessions and A.J. Piefer. Hartwick Col., NY.B44 506.6 Target genes of transcription factor c-Maf. M.Sakai. Hokkaido Univ., Japan.140PosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:25 PM-1:55 PMB34 504.1 Structure-based kinetics of bacteriophage N4RNA polymerase transcription initiation by trap-freeze X-raycrystallography. K. Murakami, R. Basu and M.L. Gleghorn.Penn State and Univ. of Rochester.
<strong>SUNDAY</strong>507. TRANSCRIPTIONAL REGULATION ANDEPIGENETICSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:25 PM-1:55 PMB45 507.1 Elevated MDR gene expression is determinedby multiple mechanisms in drug-resistant rat hepatoma celllines. I.M. Boros, Á. Sike and E. Nagy. Univ. of Szeged,Hungary.B46 507.2 HDAC1 and HDAC2 control the intestinalepithelial cell infl ammatory response. J.M. Gagné, F. Duplain-Laferrière, N. Turgeon and C. Asselin. Univ. of Sherbrooke,Canada.B47 507.3 Interactive roles of histone deacetylaseinhibitor and retinoic acid to stimulate the natriuretic peptidereceptor-A gene transcription. P. Kumar, G. Raghavaraju andK.N. Pandey. Tulane Univ. Hlth. Sci. Ctr.B48 507.4 Methamphetamine (METH) preconditioningcauses subsensitivity to METH-induced acute effects on theexpression of immediate early genes. M.T. McCoy, S. Jayanthi,G. Beauvais, B. Ladenheim, I.N. Krasnova, T. Martin, A.B.Hodges and J.L. Cadet. NIDA, NIH, Baltimore and MorganState Univ.B49 507.5 Transcriptional regulation of steroidogenicrelatedgenes by SF-1 through its dependent alternationsof chromatin structure. T. Mizutani, Y. Ju, Y. Imamichi, T.Matsumura, T. Yazawa, S. Kawabe, M. Kanno, T. Osaki, N.Minamino, A. Umezawa and K. Miyamoto. Univ. of Fukui,Natl. Cerebral and Cardiovasc. Ctr. Res. Inst., Osaka and Natl.Res. Inst. for Child Hlth. and Develop., Tokyo.B50 507.6 The tissue-restricted expression of N-alphaacetyltransferasecatalytic subunit gene Arrest Defective 1B inthe mouse and human is regulated by CpG island methylation.A.L. Y. Pang, J. Clark, W-Y. Chan and O.M. Rennert. NICHD,NIH and Sch. of Biomed. Sci., Chinese Univ. of Hong Kong.B51 507.7 Analysis of transcription factor interactionswith the β-globin gene locus throughout the cell cycle. M.H.Rosenberg, S. Liang, J. Barrow, I-J. Lin, R. Amin and J.Bungert. Univ. of Florida.B52 507.8 Biomarkers for histone deacetylase inhibitorsin animal models. S. Sharma, A. Cooper, H. Plasterer, M.Belmonte, S. Jones, S. Carreiro, V. Jacques, B. Shandra,A. Marolewski, N. Purohit, D. McCauley and J. Rusche.Repligen Corp., Waltham, MA.B53 507.9 Studying the epigenetic regulations ofposttraumatic stress disorder using a social defeat mousemodel. S. Srinivasan, S. Bintu, S-A. Miller, S. Muhie, R.Hammamieh, J. Meyerhoff and M. Jett. Walter Reed ArmyInst. of Res.B54 507.<strong>10</strong> SUZ12-dependent pathways may regulatethe intestinal epithelial infl ammatory response. N. Turgeon,M. Blais, J-F. Delabre and C. Asselin. Univ. of Sherbrooke,Canada.B55 507.11 Transcriptional regulation of vascularepigenetics by metabolic and environmental factors. J.H.Wissler. ARCONS Inst. for Applied Res. & Didactics, BadNauheim, Germany.B56 507.12 Aurora B interacts with NIR-p53, leading to p53phosphorylation in its DNA-binding domain and subsequentfunctional suppression L. Wu, C.A. Ma and A. Jain. NIAID,NIH.B57 507.13 Involvement of RanBPM in the synergisticactivation of the transcription of Epstein-Barr virus lytic genesby Rta and Zta. Y.C. Yang and L.K. Chang. Natl. Taiwan Univ.B58 507.14 Regulation of cell proliferation by a novel POKfamily protein HKR3. J-H. Yoon, W-I. Choi and M-W. Hur.Yonsei Univ. Sch. of Med., South Korea.508. RNA-BASED GENE REGULATION IN BACTERIAPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB59 508.1 Competition among small RNAs in Escherichiacoli. K. Moon and S. Gottesman. NCI, NIH.509. NON-CODING RNASPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB60 509.1 Characterization of cardiac remodeling duringpregnancy in rats. P.I. Holden, C.M. McCarty and R.L. Waikel.Eastern Kentucky Univ.B61 509.2 Estrogen mediated miRNA expression profi lesduring cardiomyocyte hypertrophy. C.M. McCarty, G.T. Risnerand R.L. Waikel. Eastern Kentucky Univ.B62 509.3 Structural characterization of theglyceraldehyde-3-phosphate dehydrogenase-mediatedregulation of endothelin-1 expression. J.P. Neal and E.D.Garcin. Univ. of Maryland Baltimore County.B63 509.4 Sex specifi c gene and microRNA regulationin cardiac remodeling. D. VanDerPloeg, G.T. Risner and R.L.Waikel. Eastern Kentucky Univ.B64 509.5 Transcriptional regulation of microRNA-200cexpression by nuclear receptor small heterodimer partner andits role in adipogenesis. L. Wang. Univ. of Utah.5<strong>10</strong>. RIBONUCLEOPROTEINSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMBIOCHEMISTRYB65 5<strong>10</strong>.1 Genomewide localization of exon junctioncomplex in Drosophila. N. Haque and M. Blanchette. StowersInst. for Med. Res., Kansas City, MO and Univ. of Kansas Sch.of Med.B66 5<strong>10</strong>.2 Small nuclear ribonucleoprotein D3 regulatessmall nucleolar RNA expression during lipotoxicity. B.S.Scruggs, C.I. Michel and J.E. Schaffer. Washington Univ.Sch. of Med.B67 5<strong>10</strong>.3 Biochemical and biophysical characterization ofrecombinantly expressed polypyrimidine tract binding proteinsfrom potato. S. Shah, D.J. Hannapel and A.G. Rao. Iowa StateUniv.141SUN
BIOCHEMISTRY511. RIBOREGULATIONPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB68 511.1 A study of covalently linked Hfqs and therequirements for RNA binding. D.J. Schu and S. Gottesman.NCI, NIH.512. RNA-BASED GENE REGULATIONPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB69 512.1 Genome-wide expression of SINE B2-mediatednatural antisense transcripts. J. Fan, D.B. Martinez-Arguellesand V. Papadopoulos. McGill Univ. Hlth. Ctr.B70 512.2 RNAi-independent role for Argonaute2 inCTCF/CP190 insulator function. N. Moshkovich, P. Nisha, P.J.Boyle, B.A. Thompson, R.K. Dale and E.P. Lei. NIDDK, NIH.B71 512.3 microRNA mediated transcriptional regulationof C17orf37. S. Rajendiran and J.K. Vishwanatha. Univ. ofNorth Texas Hlth. Sci. Ctr.B72 512.4 microRNAs that repress BMP2 inhibit lungcancer cell growth. M.B. Rogers, N. Nagarajen, D.E. Garsetti,D.T. Fritz and A.T. Lee. UMDNJ-New Jersey Med. Sch. andFeinstein Inst. for Med. Res., Manhasset, NY.B73 512.5 miR-150 regulates CXCR4 expression onbone marrow stem/progenitor cells for their mobilizationand homing into the heart during acute phase of myocardialischemia. N. Tano, K.H. Haider, H.W. Kim and M. Ashraf. Univ.of Cincinnati.B74 512.6 Using a cardiac-specifi c promoter to limit shRNAexpression from adeno-associated virus. S. Ullah, L. Lund, M.O’Donnell and M. Bond. Univ. of Maryland Baltimore.B75 512.7 The effects of nordihydroguaiaretic acid andthe function of HDAC-6 in the model organism Caenorhabditiselegans. M. Wroten. Salisbury Univ., MD.513. THE RIBOSOME AND PROTEIN TRANSLATIONPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:25 PM-1:55 PMB76 513.1 Identifi cation of a novel ribosomal subcomplexin the assembly of yeast mitochondrial ribosomes. J. Kaur andR. Stuart. Marquette Univ.B77 513.2 Cloning and characterization of two EF-Gproteins from Pseudomonas aeruginosa. S. Palmer, E. Rangleand J.M. Bullard. Univ. of Texas-Pan American.B78 513.3 Deletion of a subgroup of ribosome-relatedgenes minimizes hypoxia-induced changes and confershypoxia tolerance in Saccharomyces cerevisiae. A. Shah, D.Cadinu, R.M. Henke, S. Lianoglou, X. Xin, R.G. Dastidar andC. Leslie. Univ. of Teaxs at Dallas and Mem. Sloan-KetteringCancer Ctr.B79 513.4 Mutational analysis of a conserved residue ineukaryotic translation initiation factor 4A. G.K. Shah, K.S. Pateland W-K. Low. Saint John’s Univ., NY.B80 513.5 O-GlcNAc transferase regulates nucleolarorganization. Q. Zeidan and G.W. Hart. Johns Hopkins Univ.Sch. of Med.514. ADAMS AND OTHER PROTEASESPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:25 PM-1:55 PMB81 514.1 Development of an affi nity purifi cation systemfor isolation and proteomic analysis of cysteine proteases fromTetrahymena thermophila. K.N. Fitzgerald, J.W. Straus, J.Carreon and N. Kramer. Vassar Col. and Ramapo Col., NJ.B82 514.2 Metalloprotease-disintegrin ADAM12expression is regulated by Notch signaling via microRNA-29b. H. Li, S. Duhachek Muggy, E. Solomon, D. Sun and A.Zolkiewska. Kansas State Univ.515. GENETIC STUDIES OF PROTEIN SYNTHESISPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:25 PM-1:55 PMB83 515.1 Characterization of a NarH-interacting proteinthat regulates anaerobic growth of Pseudomonas aeruginosa.L. Pulakat, K. Raja and N. Gavini. Univ. of Missouri-Columbiaand Harry S Truman VA Med. Ctr., Bowling Green State Univ.and NHLBI, NIH.516. MECHANISMS OF PROTEIN SYNTHESISPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:25 PM-1:55 PMB84 516.1 A new look on protein dynamics in yeast. M.Breker, M. Gymrek and M. Schuldiner. Weizmann Inst. ofSci., Rehovot and MIT.517. PROTEASE: STRUCTURE AND REGULATIONPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:25 PM-1:55 PM<strong>SUNDAY</strong>B85 517.1 The role of a second shell hydrophobicinteraction in trypsin-fold serine protease function. A. Batt andT. Baird, Jr. San Francisco State Univ.B86 517.2 Proline isomerization could be a potentialregulatory mechanism of rhomboid proteases. E.Y. L. Chanand G.A. McQuibban. Univ. of Toronto.142
<strong>SUNDAY</strong>B87 517.3 Comparison of two fl uorescence-based assaysto a sensitive SDS-PAGE method for detection of trace proteasesin bovine serum albumin. E. Lang, L. Harwick, S. Stamenova,K. Rupprecht and J. Fishpaugh. Abbott Diagnostics Div.B88 517.4 Hydrohpobic interactions in an engineeredthreonine protease. M. Lansang and T. Baird, Jr. San FranciscoState Univ.B89 517.5 Antitumor activity ofrapamycin in combination with ectopic expression of Beclin 1in multidrug-resistant cancer cells. M. Lee, J-H. Ahn, K-H. Eumand Y-K. Kim. Univ. of Incheon, South Korea.B90 517.6 Carboxypeptidase O is an intestinal peptidasewith unique substrate specifi city. P.J. Lyons and L.D. Fricker.Albert Einstein Col. of Med.B91 517.7 Expression of recombinant human neutrophilelastase in Kluyveromyces lactis. E.T. Smith, J. Pugh, H.Klimecki and D.A. Johnson. East Tennessee State Univ.Quillen Col. of Med.B92 517.8 Ceruloplasmin binds and inactivates matrixmetalloproteinase-2. M.W. Thompson, J.P. Johnson and H.G.Abu-Taleb. Middle Tennessee State Univ.518. PROTEIN SYNTHESIS IN ORGANELLESPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:25 PM-1:55 PMB93 518.1 Mammalian mitochondrial ribosomal proteins:revisited. B. Kumcuoglu, H. Cimen, N. Abu, M.E. Haque, L.L.Spremulli, H. Koc and E.C. Koc. Penn State and Univ. of NorthCarolina at Chapel Hill.519. PROTEIN TURNOVER IN CELL REGULATIONPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:25 PM-1:55 PMB94 519.1 Induction of autophagic fl ux by amino aciddeprivation is distinct from nitrogen starvation-inducedmacroautophagy. H. Abeliovich, N. Ecker and D. Journo.NINDS, NIH and Hebrew Univ. of Jerusalem.B95 519.2 Functional characterization of Nedd4.1 andNedd4.2 HECT domain ligases. A.C. Augustus-Wallace, J.M.Klein and A.L. Haas. LSU Hlth. Sci. Ctr., New Orleans.B96 519.3 ClpXP modulates cell division in E. coli by amechanism that involves ATP-dependent degradation. J.L.Camberg, J.R. Hoskins and S. Wickner. NCI, NIH.B97 519.4 Molecular chaperone heat shock protein 90stabilizes nucleolin to maintain mRNA level in mitosis. J-J.Hung. Natl. Cheng Kung Univ., Taiwan.B98 519.5 Inactivation of eukaryotic initiation factor 5Aby specifi c acetylation of its hypusine residue by spermidine/spermine acetyltransferase 1. E.C. Wolff, S.B. Lee, J.H. Parkand M.H. Park. NIDCR, NIH.B99 519.6 The role of a ubiquitin processing proteasein the growth-to-development transition of Dictyosteliumdevelopment. H. Yamagata, N. Will, C. Parker and D. Lindsey.Walla Walla Univ.520. PROTEOLYTIC ENZYMES AND INHIBITORSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:25 PM-1:55 PMBIOCHEMISTRYB<strong>10</strong>0 520.1 Testing the shifting specifi city model for enzymecatalysis. B.M. Britt. Texas Woman’s Univ.B<strong>10</strong>1 520.2 Novel putative intracellular substrates orproducts for neurolysin in mice brain. L.M. Castro, C.C. C.Mendes, V. Oliveira and E.S. Ferro. Fed. Univ. of São Pauloand Univ. of São Paulo.B<strong>10</strong>2 520.3 Utilizing a protein splicing side reaction togenerate a fragment for expressed protein ligation. S.L. Chin,A.C. Nadelson, D.J. York, J.N. Reitter and K.V. Mills. Col. ofthe Holy Cross, MA.B<strong>10</strong>3 520.4 Evaluating the potency of HIV-1 proteaseinhibitors in blocking the initial step of HIV Gag-Pol processing.K. Davidoff, E. Soule, S. Daniels, D. Davis and R. Yarchoan.NCI, NIH.B<strong>10</strong>4 520.5 Effects of the neuropeptidase thimetoligopeptidase on testicular development and testosteroneproduction. T. Dhawan, J.W. Qiao, D. Selen, L.A. Bruce, M.J.Tetel and A.J. Wolfson. Wellesley Col.B<strong>10</strong>5 520.6 Determining the activation barrier and pHdependenceof each step of protein splicing. C.A. Donahue,D.J. York, D.M. Dorval, J.N. Reitter and K.V. Mills. Col. of theHoly Cross, MA.B<strong>10</strong>6 520.7 Programmed cell death in the fi lamentousfungus Schizophyllum commune. K.M. Fox, A. Major, M.Richter and Z. Zeliang. Union Col., NY.B<strong>10</strong>7 520.8 Proteolytic processing of Hendra virus fusionprotein in cells of the bat reservoir host. L. Lampe and R.E.Dutch. Univ. of Kentucky Col. of Med.B<strong>10</strong>8 520.9 Conformational change analysis of thimetoligopeptidase. Z.J. Lin, J.A. Sigman and M.J. Glucksman.Saint Mary’s Col. of California and Rosalind Franklin Univ. ofMed. and Sci.B<strong>10</strong>9 520.<strong>10</strong> The infl uence of conserved catalytic residueson the mechanism of protein splicing of the Pyrococcus abyssiPolII intein. M.D. Marieni, L.R. Duffee, D.J. York, D.M. Dorval,J.N. Reitter and K.V. Mills. Col. of the Holy Cross, MA.B1<strong>10</strong> 520.11 Non-canonical inteins: alternate mechanismsfor protein splicing. K.V. Mills, T.L. Powers, M.J. Drago, K.R.Connor and J.N. Reitter. Col. of the Holy Cross, MA.B111 520.12 Triple effect of β-nitropropionic acid onhydrolases, oxidases and transferases M. Y.H. Osman andH.M. Y. Osman. Med. Res. Inst., Alexandria, Egypt.B112 520.13 The effect of calcium on conformationalchange of thimet oligopeptidase. N.R. Pratini, B. Shaw, J.A.Sigman and M.J. Glucksman. Saint Mary’s Col. of Californiaand Rosalind Franklin Univ. of Med. and Sci.B113 520.14 Cloning and expression of putativemetacaspases from Schizophyllum commune. M. Richter.Union Col., NY.B114 520.15 Expression of a putative metacaspase genefrom Schizophyllum commune. Z. Zheng and K. Fox. UnionCol., NY.SUN143
BIOCHEMISTRY521. RIBOSOME AND TRANSLATIONPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:25 PM-1:55 PMB115 521.1 Bacterial elongation factor P: in vivo evidencefor its posttranslational modifi cation by YjeA and YjeK. J.H. Park,H.E. Johansson and M.H. Park. NIDCR, NIH and BioSearch,Novato, CA.B116 521.2 Ribopuromycylation method: a new techniquefor visualizing active cellular translation sites and exploringtranslation compartmentalization. A. David, H. Hickman, M.B.Strader, M.C. Monaco, J.R. Bennink and J.W. Yewdell. NIAID,NIMH and NINDS, NIH.B117 521.3 Investigating nonfunctional rRNA decay as astress response in Saccharomyces cerevisiae. B.M. Donovan,K.L. Jarrell and F.J. LaRiviere. Washington and Lee Univ.B118 521.4 The RNA binding domain of SBP2 is the Secspecific elongation factor binding site and the central regulatorof the Sec incorporation mechanism. J.N. Gonzalez-Floresand P.R. Copeland. UMDNJ-Robert Wood Johnson Med.Sch.B119 521.5 Monitoring changes in global gene expressionin response to nonfunctional rRNA decay in Saccharomycescerevisiae. D. Lee and F.J. LaRiviere. Washington and LeeUniv.522. KINASES, PHOSPHATASES AND PHOSPHORUSIN BIOLOGICAL REACTIONSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:25 PM-1:55 PMB120 522.1 Structural and kinetic characterization ofFrancisella tularensis acetate kinase. A.K. Drake, R.S. Isaac,M.J. Schenkel, N. Wolfson, B.G. Stancu, D. Liu and W.R. P.Novak. Wabash Col., Brandeis Unv. and Loyola Univ. Chicago.B121 522.2 Water structure of the central hydrophobiccavity of mammalian fructose 1,6-bisphosphatase: a potentialthermodynamic determinant of allowed quaternary states Y.Gao, N.D. Ginder and R.B. Honzatko. Iowa State Univ.B122 522.3 Biochemical identifi cation of PKA and PKGphosphorylation sites of the myosin phosphatase targetingsubunit support the validation of phospho-specifi c antibodies.M. Grassie, S. Brown, A. Ulke-Lemee, M. Chappellaz and J.MacDonald. Univ. of Calgary.B123 522.4 Phosphatidylserine is a critical modulator forAkt activation. H-Y. Kim, B. Huang, M. Akbar and K. Kevala.NIAAA, NIH.B124 522.5 Structural basis of activity for plant glucanphosphatases. D.A. Meekins, C.W. Vander Kooi and M.S.Gentry. Univ. of Kentucky Col. of Med.B125 522.6 Substrate inhibition of A. thaliana adenosine 5’phosphosulfate kinase by APS occurs via multiple modes. G.E.Ravilious and J. Jez. Washington Univ. in St. Louis.B126 522.7 Effect of cinnamon on plasma glucoseconcentration and the regulation of 6-phosphofructo-1-kinaseactivity from the liver and small intestine of streptozotocin-induceddiabetic rats. S.S. Yaghmoor. King Abdulaziz Univ., Saudi Arabia.B127 522.8 Characterization of the novel catalyticand regulatory properties of the alpha-kinase domain ofDictyostelium myosin heavy chain kinase A. Y. Yang, S.W.Crawley, Q. Ye, M.S. Gharaei, Z. Jia and G.P. Côté. Queen’sUniv., Canada.523. BIOSYNTHESIS OF SULFUR-CONTAININGCOFACTORS AND METABOLITESPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:25 PM-1:55 PMB128 523.1 Function of aspartate 458 in human glutathionesynthetase. T. Brown, K. Slavens, M. De Jesus, M. Drummond,A. Crutchfield, B. Shrestha, S. Barelier, A. Dinescu, T.R.Cundari and M. Anderson. Texas Woman’s Univ., Univ. ofNorth Texas and Wilkes Univ., PA.B129 523.2 Insights into the inhibition of E. coli gammaglutamylcysteineligase by sulfoximines. B. Johnson-Teschand B.S. Kelly. Gustavus Adolphus Col., MN.B130 523.3 Identifi cation and monitoring of gammaglutamylcysteineligase inhibition in cells. J. Li and B.S. Kelly.Gustavus Adolphus Col., MN.B131 523.4 Hydrophobic interactions at the dimer interfaceof glutathione synthetase. K. Slavens, M. De Jesus, T. Brown,A. Graves, K. Barakat, T.R. Cundari and M.E. Anderson.Texas Woman’s Univ. and Univ. of North Texas.524. DESIGN OF PHOSPHATASE AND KINASEINHIBITORS AS DRUG TARGETSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:25 PM-1:55 PMB132 524.1 Profi ling the kinome of drug resistant chronicmyelogenous leukemia. N.J. Cox, E.I. Zimmerman, B.J.Dewar, J. Duncan, M. Whittle, J. Jin, S.V. Frye, G.L. Johnsonand L.M. Graves. Univ. of North Carolina Sch. of Med., Sch. ofPharm. and Lineberger Comprehen. Cancer Ctr.525. ENZYMOLOGY OF PHOSPHORYL TRANSFERPoster<strong>SUNDAY</strong>SUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCStructure, Mechanism and Regulation in EnzymeCatalysisChemical <strong>Biology</strong> and Drug DiscoveryPresentation time: 12:25 PM-1:55 PMB133 525.1 Investigations of the determinants of ATPbinding in the active site of 5,<strong>10</strong>-methenyltetrahydrofolatesynthetase form Mycoplasma pneumonia T.W. Johann, L.S.Bickford, M.R. Tolley and K. Clare. Roanoke Col., VA.B134 525.2 Identifying residues involved in active sitecommunication in creatine kinase. S.F. Wanner and P.L.Edmiston. Col. of Wooster, OH.144
<strong>SUNDAY</strong>526. SULFUR-DEPENDENT REDOX REGULATIONPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:25 PM-1:55 PMB135 526.1 Effects of electrophilic modifi cation on theactivity of thioredoxin peroxidase 1 from Saccharomycescerevisiae. H.A. Brown, C.E. Stamm and J.D. West. Col. ofWooster, OH.B136 526.2 Redox regulation of JNK2 activity throughcysteine sulfenic acid formation in chondrocytes. E.A. Erickson,R.R. Yammani, A.W. Tsang, J.S. Fetrow, L.B. Poole, C.M.Furdui and R.F. Loeser. Wake Forest Univ. Sch. of Med. andWake Forest Univ.B137 526.3 Probing disulfi de bonding in vivo usingimmobilized PAO-affi nity chromatography. T.D. Foley, A.E.Healey, E.J. Lucas, A.R. Clark, N.E. Benfante, J.A. Wagner,T.L. Salmon and M.A. Gubbiotti. Univ. of Scranton.B138 526.4 Identifi cation of genes that provide cellularprotection against a thiol cross-linking agent in Saccharomycescerevisiae. C.E. Stamm, S.L. Justice and J.D. West. Col. ofWooster, OH.B139 526.5 Structure-activity comparison of the cytotoxicproperties of diethylmaleate and related molecules: identifi cationof diethyl acetylenedicarboxylate as a thiol cross-linking agent.J.D. West, C.E. Stamm and P.J. Kingsley. Col. of Wooster andVanderbilt Univ.527. MITOCHONDRIAL FUNCTION AND DISEASEPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:25 PM-1:55 PMB140 527.1 Mutation of ribonucleotide reductase smallsubunit p53R2 affects deoxynucleotide metabolism in quiescentbut not in cycling human fi broblasts. V. Bianchi, G. Pontarin, P.Ferraro, C. Rampazzo and P. Reichard. Univ. of Padua, Italy.B141 527.2 HCV induced oxidative stress, mitochondrialdamage, and autophagy in human hepatoma cells V. Chu, S.Bhattacharya, J. Lin, A. Nomoto, S. Azhar, S.A. Weinmanand T-T. Huang. Stanford Univ., VA Palo Alto Hlth. Care Syst.and Univ. of Kansas Med. Ctr.B142 527.3 Nutrient-sensitized screening for drugs thatshift energy metabolism from mitochondrial respiration toglycolysis. V.M. Gohil, S.A. Sheth, R. Nilsson, J-H. Lee, A.P.Wojtovich, F. Perocchi, W. Chen, C. Clish, C. Ayata, P.S.Brookes and V. Mootha. Massachusetts Gen. Hosp., Bostonand Charlestown, Univ. of Rochester Med. Ctr. and Broad Inst.of MIT and Harvard.B143 527.4 Direct inhibitory effects of phospholipaseA2 enzymatic product lysophosphatidylcholine on hepaticmitochondria. N.I. Hollie, M.A. Matlib and D.Y. Hui. Univ. ofCincinnati.B144 527.5 Effect of ionizing radiation on mitochondria inhuman cells. S. Kaufer and W. Pogozelski. SUNY Geneseo.B145 527.6 Fatty acid oxidation in the aged heart. J. Kernerand C. Hoppel. Case Western Reserve Univ.BIOCHEMISTRYB146 527.7 Heart mitochondrial fatty acid oxidation is notaffected by deletion of the fatty acid transporter CD36/FAT. J.Kerner, M. Febbraio and C. Hoppel. Case Western ReserveUniv. and Cleveland Clin. Fndn.B147 527.8 PGC-1α protects dopaminergic neurons in theMPTP mouse model of Parkinson’s disease. D. Lindholm, G.Mudò, J. Mäkelä, T. Tselykh, L. Korhonen and N. Belluardo.Inst. of Biomed., Helsinki and Div. of Human Physiol., Palermo.B148 527.9 Warburg in reverse: the autophagic tumorstroma model of cancer metabolism. M.P. Lisanti, F. Sotgiaand U.E. Martinez-Outschoorn. Thomas Jefferson Univ.B149 527.<strong>10</strong> Boosting mitochondrial function to minimizeischemia-reperfusion injury. S. Liu, Y. Soong, Z. Zhao, S.Seshan and H. Szeto. Weill Cornell Med. Col.B150 527.11 SIRT3-dependent protein deacetylationmodulates susceptibility to acetaminophen-induced liver injury.Z. Lu, M. Bourdi, A. Aponte, D.B. Lombard, M. Gucek, L.R.Pohl and M.N. Sack. NHLBI, NIH and Univ. of Michigan.B151 527.12 Imaging intracellular and intramitochondrialzinc concentrations following hypoxia/hypoglycemia withan expressible fl uorescence biosensor. B.J. McCranor, L.Bambrick, B.M. Polster, R.A. Bozym, M. Vitolo, G. Fiskum,C.A. Fierke and R.B. Thompson. Univ. of Maryland Sch. ofMed. and Univ. of Michigan.B152 527.13 Investigation of the role of mitochondrial onecarbonmetabolism in developing and adult mammals. J. Momb,J. Bryant, J. Lewandowski, S. Vokes and D.R. Appling. Univ.of Texas at Austin.B153 527.14 Functional properties of isolated mitochondriadiffer from those of permeabilized myofi bers. M. Picard,T. Taivassalo, D. Ritchie, K.J. Wright, M.M. Thomas, C.Romestaing and R.T. Hepple. McGill Univ., Univ. of Calgaryand Univ. of Lyon.B154 527.15 Effect of oxidative stress on mitochondria inhuman cells bearing elevated levels of a large-scale deletionin mitochondrial DNA. M. Siegenthaler and W. Pogozelski.SUNY Geneseo.B155 527.16 Detection and quantifi cation assays forlarge-scale mitochondrial DNA deletions in human cells. M.Siegenthaler and W. Pogozelski. SUNY Geneseo.B156 527.17 Regulation of mitochondrial folate-mediatedone-carbon metabolism through lysine acetylation. A.Solmonson, J. Bryant, J. Momb and D. Appling. Univ. ofTexas at Austin.B157 527.18 Mechanism of cytochrome oxidase dysfunctionin hypoxia and myocardial ischemia. S. Srinivasan, D. Galati,M. Hardy, K. Chandran, J. Spear and B. Kalyanaraman. Univ.of Pennsylvania and Med. Col. of Wisconsin.B158 527.19 The development of a therapeutic peptide formitochondrial protection—from bench to bedside. H.H. Szeto.Weill Cornell Med. Col.B159 527.20 A novel anti-aging compound extends longevityby altering the age-related dynamics of reactive oxygen species.V. Titorenko, A. Goldberg, P. Kyryakov, S. Bourque, A. Beach,M. Burstein and V. Richard. Concordia Univ., Canada.SUN145
BIOCHEMISTRY<strong>SUNDAY</strong>528. AGING AND METABOLISMPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:25 PM-1:55 PMB160 528.1 Bidirectional vitamin transport and themechanism of calorie restriction. C. Brenner. Univ. of Iowa.B161 528.2 Dietary glycine supplementation mimicslifespan extension by dietary methionine restriction in Fisher344 rats. J. Brind, V. Malloy, I. Augie, N. Caliendo, J.H.Vogelman, J.A. Zimmerman and N. Orentreich. Baruch Col.,CUNY, Orentreich Fndn. for Adv. of Sci. Inc., Cold Spring-on-Hudson, NY and St. John’s Univ., NY.B162 528.3 Klotho protects against oxidative stress throughantioxidant and apoptotic signaling pathways. R. Brobey, K-O.Makoto and K. Rosenblatt. Univ. of Texas Hlth. Sci. Ctr. atHouston and Univ. of Texas Southwestern Med. Ctr. at Dallas.B163 528.4 TIAF1 self-aggregation precedes amyloid betaformation in vivo. N-S. Chang. Natl. Cheng Kung Univ., Taiwanand SUNY Upstate Med. Univ.B164 528.5 The role of singlet oxygen in the UVA-inducedbystander effect on dermal fi broblasts. J.G. Gao, A. Shih andM. Simon. Stony Brook Univ.B165 528.6 Long-chain glycosphingolipids mediate renalaging. M. Hernandez-Corbacho, A.R. Mather, R. Jenkins, C.Clarke, Y. Hannun, L. Obeid, A. Snider and L. Siskind. Med.Univ. of South Carolina and Ralph H. Johnson VA Med. Ctr.B166 528.7 Modulation of mosquito lifespan by resveratrol.R.D. Nunes, D.M. Moretti, C.O. Cudischevitch, P.R.Bittencourt-Cunha, J. H.M. Oliveira, R.L. S. Gonçalves, D.S.Gusmão, D.S. Alviano, F.J. A. Lemos, G.C. Atella and M.A.C. Silva-Neto. Fed. Univ. of Rio de Janeiro and Univ. of NorthFluminense Province, Brazil.B167 528.8 The infl uence of p66Shc on whole body energymetabolism in mice. J.H. Stern, K. Hagopian, G.A. Cortopassiand J.J. Ramsey. Univ. of California, Davis.B168 528.9 Shared mechanisms in adenylyl cyclase type5 knockout and caloric restriction. L. Yan, J.Y. Park, M.S. DeLorenzo, H. Ge, L. Lai, B. Tian, J. Sadoshima, D.E. Vatnerand S.F. Vatner. UMDNJ, Newark.529. GLUCOLIPOTOXICITY AND METABOLICSTRESSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:25 PM-1:55 PMB169 529.1 NADPH oxidase 4 mediates metabolic stressinducedhyper-responsiveness of monocytes to MCP-1. C.F.Lee, Q. Zhao, S.L. Ullevig, H.S. Kim and R. Asmis. Univ. ofTexas Hlth. Sci. Ctr. at San Antonio.530. METABOLISM AND DIABETES IPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:25 PM-1:55 PMSee Metabolism and Diabetes II scheduled Monday.B170 530.1 Effect of artifi cial sweeteners on insulinsecretion, ROS, and oxygen consumption in pancreatic betacells A.M. Al-Saleh, B. Corkey, J. Deeney, K. Tornheim andE. Bauer. Boston Univ. Sch. of Med. and Rivers Sch., Weston,MA.B171 530.2 Altered O-GlcNAc modifi cation andphosphorylation of mitochondrial proteins in myoblast cellsexposed to high glucose. S.R. Ande, Y. Gu and S. Mishra.Univ. of Manitoba.B172 530.3 Effects of catalase overexpression on redoxbalance and insulin resistance in skeletal muscle cells. M.R.Barbosa, I. Sampaio, V. Casagrande, L. Parreiras-E-Silva, R.Reis, L.C. Alberici, E. Carneiro, R. Curi and L.D. R. Silveira.Univ. of São Paulo, Ribeirão Preto.B173 530.4 BIGH3: a new target in diabetic complications.J.M. Castaneda-Gill, S. Hardikar, M. Navarro, E. Kotchan,H.S. Kim, Q. Zhao, C.F. Lee, A. Tsin, R. Asmis and R.LeBaron. Univ. of Texas at San Antonio and Univ. of Texas Hlth.Sci. Ctr. at San Antonio.B174 530.5 Evaluation of the effectiveness of the insulinmimetics,selenium and vanadium, in insulin-resistance inprimary hepatocytes S. Coulibaly, K. McPherson, S. Nair, D.Ruff II and S.R. Stapleton. Western Michigan Univ.B175 530.6 Hexokinase and phosphofructokinase aspossible targets of insulin-independent cardioprotective actionof metformin. D. Da Silva, P.A. De Oliveira, W.S. Coelho, P.Zancan, E.M. de Alencar and M. Sola-Penna. Fed. Univ. ofRio de Janeiro.B176 530.7 Characterization of ATP<strong>10</strong>C and multiplesignaling pathway proteins in C2C12 cells using immunoblotassays and immunofl uorescence microscopy. S.E. Hurst,S. Minkin, J. Biggerstaff and M. Dhar. Univ. of Tennessee,Knoxville.B177 530.8 Benefi cial metabolic effects of conditionalactivation of Gq signaling in pancreatic β-cells. S. Jain, J-M.Guettier and J. Wess. NIDDK, NIH.B178 530.9 Regulation of cardiac oxidative stress and lipidperoxidation in streptozotocin-induced diabetic rats treated withaqueous extract of Pimpinella tirupatiensis tuberous root. S.R.Kesireddy, R.R. Saddala, L.T. Reddy and S.N. Ganapathi.Sri Venkateswara Univ., India.B179 530.<strong>10</strong> Lack of PanK1 improves insulin sensitivity andglucose tolerance by activating AMPK in skeletal muscle. R.Leonardi, C.O. Rock and S. Jackowski. St. Jude Children’sRes. Hosp.B180 530.11 Effect of administration of Eryngium carlinaeon lipid profi le in diabetes. R. Noriega-Cisneros, C. Cortés-Rojo, E. Calderón-Cortés, M. Clemente-Guerrero, S. Manzo-Avalos and A. Saavedra-Molina. Univ. Michoacana of SanNicolás de Hidalgo, Mexico.146
<strong>SUNDAY</strong>531. MITOCHONDRIA-DERIVED SIGNALSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:25 PM-1:55 PMB181 531.1 Mitochondria as autonomous sensors oftemperature fl uctuations. M.E. Glasheen, M-C.G. Marcondes,B. Conti and S.S. Ali. UCSD and San Diego VA Hosp. and TheScripps Res. Inst.532. FRONTIERS IN OBESITY RESEARCHPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB182 532.1 Mesenteric and omental depot differences in fattissue infl ammatory markers and signaling from type 2 diabeticand normal obese humans. T. Ghansah, M. Murr, J.E. Watson,S. Yoder, D. Fleming, N. Nelson, Y. Peng, A. Apostolatos, K.Gower, N.A. Patel and D.R. Cooper. Univ. of South Florida,James A Haley Veterans Hosp. and Moffi tt Cancer Ctr.B183 532.2 The plateau principle, a model of approach tosteady state for weight and metabolic functions after bariatricsurgery J.L. Hargrove, G. Heinz, J.W. Smith, J. Frediani, T.R.Ziegler, E. Lin and N. Gletsu-Miller. Univ. of Georgia, PrivateConsultant, Carmel, CA and Emory Univ. Sch. of Med.B184 532.3 Regulation of peroxisome proliferator-activatedreceptorγ, caspase 9b, and PKCβII alternative splicing by Clk1kinase in 3T3-L1 preadipocytes P. Li, J. Romero, K. Gower,J.E. Watson, G. Carter, H. Apostolatos, S. Yoder, T. Ghansah,N.A. Patel and D.R. Cooper. Univ. of South Florida, JA HaleyVA Hosp. and Moffi tt Cancer Ctr., Tampa.B185 532.4 Myeloperoxidase and fat tissue deregulationduring obesity. D.C. Ramirez and S.E. Gomez-Mejiba.Oklahoma Med. Res. Fndn.533. DISPARITIES IN OBESITYPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB186 533.1 Adipocyte and adipose tissue gene expressionin subjects with different body mass indexes with and withoutinsulin resistance. A. Serralde, A.R. Tovar, I. Medina-Vera, L.Gil-Zenteno and N. Torres. Natl. Inst. of Med. Sci. and Nutr.Salvador Zubirán, Mexico City.534. OBESITY AND THE METABOLIC SYNDROMEPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMBIOCHEMISTRYB187 534.1 Regulation of de novo lipid synthesis by smallorganic molecules, fatostatins L. Abu-Elheiga, M. Uesugi andS. Wakil. Baylor Col. of Med. and Kyoto Univ.B188 534.2 Inhibition of SCD activity in RAW264.7macrophages promotes endoplasmic reticulum stress responsebut decreases lipogenesis while enhancing cholesteroltraffi cking. Z. Akhtar, X. Liu and J. Ntambi. Univ. of Wisconsin-Madison.B189 534.3 Hypertrophic adipocytes decreased insulinsensitivity due to lipid dysregulation. J.I. Kim, J.Y. Huh andJ.B. Kim. Seoul Natl. Univ.B190 534.4 The increased expression of PPARγ isresponsible for the fatty acid transport and lipid accumulation indiet-induced hepatic steatosis. Y.J. Lee, E.H. Ko, J. Pang, S.W.Park and J-W. Kim. Yonsei Univ. Col. of Med., South Korea.B191 534.5 The effect of FXR ligands on fatty liver modelof cultured cells. T. Miyazaki, A. Honda, T. Ikegami, M. Shiraiand Y. Matsuzaki. Tokyo Med. Univ.B192 534.6 Effects of estrogen and leptin on hypothalamicagouti-related peptide/neuropeptide Y synaptic density. C.E.Okona, J. Newton and A.W. Xu. Oberlin Col. and UCSF.B193 534.7 Development of high-fat diet-induced obesityand hepatic infl ammation in NEIL1 defi cient mice. H. Sampath,A. Batra, V. Vartanian, J.R. Carmical, D. Prusak, I.B. King, B.Lowell, L.F. Earley, T.G. Wood, D.L. Marks, A.K. McCulloughand R.S. Lloyd. Oregon Hlth. & Sci. Univ., Univ. of Texas Med.Branch and Univ. of New Mexico.B194 534.8 Brown adipocyte activation is characterizedby a wave of mitochondrial fi ssion and depolarization thatis dependent on β3 receptor stimulation and Drp1, and ischaracterized by complete, but reversible, arrest of fusionS. Sereda, J. Wikstrom, Y. Si, G. Twig, M. Liesa, G. Las, B.Cannon, J. Nedergaard and O. Shirihai. Boston Univ. andStockholm Univ.B195 534.9 Increased production of the adipocyte hormoneadiponectin in mice lacking neutrophil cytosolic factor 1. M.Shtayer, M. Nunez, G. Chen, C. Stump and T-S. Tsao. Univ.of Arizona, Univ. of Arizona Hlth. Sci. Ctr. and Southern ArizonaVA Hlth. Care Syst.B196 534.<strong>10</strong> Identifi cation of new molecular componentsin the GLUT4 clusters in the plasma membrane of adiposecells by mass spectrometry-based proteomics. J. Yang, X. Xie,D.E. Anderson, K.G. Stenkula, D. Yver, C. Meyer and S.W.Cushman. NIDDK, NIH, Univ. of South Alabama Col. of Med.and Arizona State Univ.SUN147
BIOCHEMISTRY<strong>SUNDAY</strong>535. SYSTEMS BIOLOGYPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCChemical <strong>Biology</strong> and Drug DiscoveryStructure, Mechanism and Regulation in EnzymeCatalysisPresentation time: 1:05 PM-2:35 PMB197 535.1 Bacterial stress response to hydrogen peroxide.K. Cade. Rutgers Univ., Camden.B198 535.2 Transcriptomic and histopathologiccharacterization of mouse model(s) simulating features ofpost-traumatic stress disorder. S. Muhie, R. Hammamieh, S-A.Miller, J. Meyerhoff, E. Carroll and M. Jett. Walter Reed ArmyInst. of Res. and Naval Med. Res. Ctr.B199 535.3 Comparative developmental and evolutionarystudies of new Caenorhabditis species in Virginia. B.A. Wang,E.A. Haynes and T.M. Grana. Univ. of Mary Washington.B200 535.4 Phosphoproteome profi ling of HEK 293 cellsunder osmotic stress using SILAC. R. Wang, J.D. Ferraris, G.Wang, M. Gucek and M.B. Burg. NHLBI, NIH.536. EXPERIMENTAL AND COMPUTATIONALAPPROACHES TO SYSTEMSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB201 536.1 Minimizing model output uncertainty using aglobal, parallel model-based design of experiments approachJ.N. Bazil, G.T. Buzzard and A.E. Rundell. Med. Col. ofWisconsin and Purdue Univ. Weldon Sch. of Biomed. Engin.B202 536.2 Combining computational and experimentalapproaches to investigate the catalytic mechanism ofglyoxysomal malate dehydrogenase. H. Guterres, S. Hedrickand E. Bell. Univ. of Richmond.B203 536.3 Systematic computational and experimentalidentifi cation of trans-factors that modulate posttranscriptionalgene expression of the hypoxia inducible factor 1 alpha. R.Mrowka, A. Bondke Persson, A. Steege, A. Patzak, P.B.Persson and M. Fähling. Friedrich Schiller Univ. Jena andCharité, Med. Univ. Berlin.B204 536.4 NIGMS PSI:<strong>Biology</strong> Initiative – enabling highthroughputstructural biology and structural genomics. W.Smith, A. Ainsztein, R. Basavappa, J. Chin, C. Edmonds, P.Flicker, P. Preusch, J. Wehrle, C. Lewis and J. Berg. NIGMS,NIH.537. GENOMICS AND TOXICOGENOMICSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB205 537.1 The effect of atrazine on the thyroid axis inzebrafi sh. J.L. Sine, G.T. Ayers and D.M. Baker. Univ. of MaryWashington.538. MATHEMATICAL BIOLOGYPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB206 538.1 A matrix model of fasting metabolism innorthern elephant seal pups. E.O. Keith. Nova SoutheasternUniv., FL.539. MICROARRAYSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB207 539.1 Lysophosphatidic acid regulates a complexarray of genes in human gingival fi broblasts. D.R. Cerutis, M.D.Weston, A. Ogunleye, T.P. McVaney, K.V. Headen and L.C.Parrish. Creighton Univ.B208 539.2 E3 and DUB substrate identifi cation, andchain linkage profi ling using microarrays C.M. Loch and J.E.Strickler. LifeSensors Inc., Malvern, PA.540. METHODSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB209 540.1 A one-solution, one-tube plasmid DNA miniprepL. Brunelli, M.R. Kuehn and G. Lezin. Univ. of Utah and NCI-Frederick.B2<strong>10</strong> 540.2 Hofmeister series salts enhance purifi cation ofplasmid DNA by non-ionic detergents. L. Brunelli, M.R. Kuehnand G. Lezin. Univ. of Utah and NCI-Frederick.B211 540.3 Identifi cation of Akt-interacting proteinsusing on-beads cross-linking, co-immunoprecipitation andmass spectrometry B.X. Huang and H-Y. Kim. NIAAA, NIH,Rockville.B212 540.4 Universal phosphatase-coupled glycosyltransferaseassay. W. Jiang, C. Ethen, B. Prather, M. Machacekand Z. Wu. R&D Systems Inc., Minneapolis.B213 540.5 Detection of specifi c glycosaminoglycansand glycan epitopes by in vitro sulfation using recombinantsulfotransferases. W. Jiang, B. Prather, C. Ethen, A. Kalyuzhnyand Z. Wu. R&D Systems Inc., Minneapolis.148
<strong>SUNDAY</strong>B214 540.6 A hight throughput protocol for using soilmolecular biology as trace evidence. S.A. Larson, N. Petal,J. Hustedt, R.A. Drijber, D.O. Carter and C.P. Bailey. Univ. ofNebraska-Lincoln.B215 540.7 Direct, rapid, and effi cient transesterifi cation oftotal lipids in human serum by microwave irradiation Y.H. Lin,S. Strandjord, J.D. Loewke, D.Y. Hyun, J. Leazer and J.R.Hibbeln. NIAAA, NIH and CEM Corp., Matthews, NC.B216 540.8 Characterization of a real-time PCR assayfor the detection and quantitation of Plasmodium malariaeparasites. E. Parsons, J. Koros, C. Obuya, D. Aching andA. Stewart. Kalamazoo Col., U.S. Army Med. Res.-Kenya andWalter Reed Army Inst. of Res.B217 540.9 Synthesis of 1, 13-dichloro 5, 6, 8, 9-tetraazadibenzo anthracene, helical considerations Y.A. Puplampu-Dove and G. Mandouma. Univ. of Maryland Eastern Shoreand Furman Univ.B218 540.<strong>10</strong> Chromatin immunoprecipitation: revisiting theeffi cacy of sample preparation and sonication, and of shearedDNA extraction, quantifi cation, and analysis via polymerasechain reaction P.D. S. Bortz and B.R. Wamhoff. Univ. ofVirginia.B219 540.11 The multiple solvent crystal structures ofP22TSP. M.D. Smith, C. Mattos and S. Barbiz. North CarolinaState Univ. and Univ. Potsdam, Germany.B220 540.12 Increase of BCR-ABL/ABL ratio thatcorresponds to BCR-ABL mutation detection in chronic myeloidleukemia patients treated by imatinib. G. Tsaur, A. Popov, A.Ivanova, Y. Yakovleva, T. Riger, O. Plekhanova, Y. Ivanets, E.Shorikov, L. Saveliev and L. Fechina. Reg. Children’s Hosp.#1 and Novartis Pharma, Yekaterinburg, Russia.B221 540.13 Development of a multiplex immunoassay forphosphothreonine protein analysis. R. Wiese, S. Harbison andD. Hayes. EMD Millipore, St. Charles, MO.541. MASS SPECTROSCOPYPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB222 541.1 Quantifi cation of eicosanoid pathway proteinsin human cerebrospinal fl uid using a dual pressure linear iontrap mass spectrometer. R.G. Biringer, J.A. Horner, A.N.Fonteh, S. Kauffman, A.F. R. Hühmer and M.G. Harrington.Thermo Fisher Scientifi c, San Jose and Huntington Med. Res.Insts., Pasadena.B223 541.2 Characterization of specifi c lysophosphatidicacid subspecies produced by autotaxin using a novel LC/MS/MS method. E. Mayton, D.S. Wijesinghe, J. Mietla, X. Fangand C.E. Chalfant. Virginia Commonweatlh Univ. and HunterHolmes McGuire VA Med. Ctr.B224 541.3 An approach to standardize Lepidium meyenii(Maca) extracts by evaluating macamide content with an LC-MS/MS method. A.J. Pino-Figueroa, M. Bohlke, H. Wu, C.Kelley, D.A. Williams and T.J. Maher. Massachusetts Col. ofPharm. and Hlth. Sci.B225 541.4 Optimized MS quantitation of knockdown,transcription factor profi les and isoform modulation during stemcell differentiation. J. Swift, T. Harada, J-W. Shin, M. Tewari,H-Y. Tang, D.W. Speicher and D.E. Discher. The Wistar Inst.and Univ. of Pennsylvania.542. CELL CYCLEPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB226 542.1 Biochemical and immunocytochemical analysisof proteins transiently associated with the chromosomalpassenger complex during mitosis. S.L. Faitar, J. Vokes, K.Pundt and Z. Wintrob. D’Youville Col., NY.B227 542.2 Nucleoporin Nup88 orchestrates properchromosomal segregation through its interaction with Cdc20during mitosis. C. Hashizume. Kanazawa Univ., Japan.543. CELL CYCLE AND GROWTH CONTROLPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMBIOCHEMISTRYB228 543.1 Overexpression of HDAC1 modulates cervicalcancer cells proliferation by raised expression of PP2Ac. J-Y.Chuang, W-C. Chang and J-J. Hung. Natl. Cheng Kung Univ.,Taiwan.B229 543.2 Serine-threonine kinase receptor-associatedprotein activates B-myb function through direct interaction. H.Ha, H-A. Seong and R. Manoharan. Chungbuk Natl. Univ.,South Korea.B230 543.3 The activation of P2Y11 inhibits cell proliferationby induction of cell cycle arrest and cell autophagy in endothelialcells. J. Hu, Z. Xiao, M. Yang, Q. Lv, M. Deng, X. Liu, X. Chen,M. Chen, L. Fang and X. Xie. Renmin Hosp., Wuhan Univ.and Xiangya Hosp., Central South Univ., People’s Republic ofChina.B231 543.4 Natural oils as cancer suppressors. S.J.Majeno, C.A. Ibarra and N.S. Parmar. California State Univ.Channel Islands.B232 543.5 Interferon-induced growth suppression: aGRIM path. S.C. Nallar, S. Kalakonda and D.V. Kalvakolanu.Univ. of Maryland Sch. of Med.B233 543.6 Reduction of CTGF/CCN2 induces cell cyclearrest in primary human adult skin fi broblasts. C.M. Ruth, G.Fisher, J. Chrivia, J. Baldassare, T. Quan and T. He. SaintLouis Univ. and Univ. of Michigan Med. Sch.B234 543.7 The role of hydrogen peroxide as anendogenous growth factor in human breast cancer cells. S.Sen, B. Kawahara and G. Chaudhuri. UCLA.B235 543.8 Molecular mechanisms by which ciclopiroxinhibits proliferation and induces apoptosis of tumor cells. T.Shen, H. Zhou and S. Huang. LSU Hlth. Sci. Ctr., Shreveport.SUN149
BIOCHEMISTRY<strong>SUNDAY</strong>544. CYCLINS AND CYCLIN-DEPENDENT KINASESPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB236 544.1 Are chemical inhibitors an effective way to studythe role of cyclin-dependent kinase 5 in neuronal and pancreaticdevelopment? Comparative kinase assays provide the answer.D.E. Khost and A. Aguanno. Marymount Manhattan Col.B237 544.2 Characterization of a genetic interactionbetween SBP1 and WHI3 in Saccharyomyces cerevisiae. K.M.Theede and S.P. Segal. Winona State Univ., MN.545. CHROMOSOME SEGREGATION ANDANEUPLOIDYPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB238 545.1 Human SMARCAL1, a member of the SWI2/SNF2 family, is required for cell division D.T. Haokip, R. Kumariand R. Muthuswami. Sch. of Life Sci., Jawaharlal Nehru Univ.,India.546. MITOTIC SPINDLEPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB239 546.1 RNA export factor Rae1 interacts with cohesinsubunit SMC1 at the mitotic spindle pole. T. Funasaka and R.Wong. Kanazawa Univ., Japan.547. CURRENT TOPICS IN PHOSPHOINOSITIDEBIOLOGY AND SIGNALINGPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:25 PM-1:55 PMB240 547.1 Studying the distribution of phosphatidylinositoland its roles in maintaining organelle structure and signaling.Y.J. Kim and T. Balla. NICHD, NIH.548. LIPID SECOND MESSENGERSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:25 PM-1:55 PMB241 548.1 The PLD2 product cyclic phosphatidic acid is anovel lipid second messenger that inhibits the nuclear hormonereceptor PPARγ. R. Tsukahara, T. Tsukahara, Y. Fujiwara, J.Yue, Y. Cheng, H. Guo, A. Bolen, C. Zhang, L. Balazs, F. Re,G. Du, M.A. Frohman, D.L. Baker, A.L. Parrill, K. Murakami-Murofushi and G. Tigyi. Univ. of Tennessee Hlth. Sci. Ctr.,Memphis, Univ. of Texas Hlth. Sci. Ctr. at Houston, Stony BrookUniv. and Univ. of Memphis.549. LIPID SIGNALINGPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:25 PM-1:55 PMB242 549.1 There is more to a lipid than just being a fat:sphingolipid-guided differentiation of oligodendroglial lineagefrom embryonic stem cells. E. Bieberich. Med. Col. of Georgia/Georgia Hlth. Sci. Univ.B243 549.2 Regulation of ERM cytoskeletal proteins bysphingolipids. D. Canals, A. Orr, P. Roddy, L.M. Obeid andY.A. Hannun. Med. Univ. of South Carolina.B244 549.3 Role of class I myosin in phagocytosis throughPtdIns(3,4,5)p3 signaling C-L. Chen and M. Iijima. JohnsHopkins Univ.B245 549.4 Nuclear SphK2 and S1P regulate STAT3acetylation and transcriptional activity. N.C. Hait, J. Allegood,T. Kordula, S. Milstien and S. Spiegel.B246 549.5 Sphingosine-1-phosphate: a missing cofactorfor lysine 63-linked polyubiquitinations in signaling by proinflammatory cytokines. K.B. Harikumar, N.C. Hait, J.Allegood, E.Y. Kim, M. Maceyka, S. Milstien, S. Spiegel andT. Kordula. Virginia Commonwealth Univ.B247 549.6 Docosapentaenoic acid also inducesneurogenesis in cultured neural stem cells. M. Katakura andH-Y. Kim. NIAAA, NIH.B248 549.7 Sustained treatment of PMA affects traffi ckingand signaling of EGFR. M. Liu, J. Idkowiak-Baldys, P. Roddy,A. Baldys, J. Raymond and Y.A. Hannun. Med. Univ. of SouthCarolina.550. LIPIDS AND CONTROL OF GENE EXPRESSIONPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:25 PM-1:55 PMB249 550.1 Overexpression of catalase negates thebenefi cial effects of dietary lipids on plasma triglyceride andAPOA1/C3/A5 pathway. J. Fei, A. Wheaton, C. Ennis, C. Cook,S. Parthasarathy and N. Santanam. Marshall Univ., EmoryUniv. Sch. of Med. and Ohio State Univ.150
<strong>SUNDAY</strong>B250 550.2 Temperature-induced changes in theexpression of genes for membrane lipid metabolism in Chinooksalmon cells. S.E. Kunciw, H.K. Desai and E.E. Williams.Salisbury Univ., MD.B251 550.3 Role of PAH1-encoded PA phosphatase intriacylglycerol synthesis in yeast. F. Pascual, A. Soto and G.M.Carman. Rutgers Univ.B252 550.4 Protein kinase A phosphorylates and regulatesyeast phosphatidate phosphatase. W-M. Su, J. Casciano andG.M. Carman. Rutgers Univ.551. LIPIDS AND INFLAMMATIONPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:25 PM-1:55 PMB253 551.1 The phospholipase A1 activity of acyl-proteinthioesterase links platelet activation to LPA production duringblood clotting. A.L. Bolen, A.P. Naren, D.L. Baker, S. Beranova-Giorgianni, M.D. Best, M.M. Rowland, D.D. Norman, L. Chen,S. Yarlagadda, T. Sano, T. Tsukahara, Y. Igarashi, G. Tigyi andK. Liliom. Univ. of Tennessee Hlth. Sci. Ctr., Univ. of Memphis,Univ. of Tennessee, Knoxville and Hokkaido Univ., Japan.B254 551.2 Cerebrospinal fl uid phospholipase A2 isoformschange in migraine. A.N. Fonteh, R. Biringer, A. Huhmer andM. Harrington. Huntington Med. Res. Insts., Pasadena andThermo Fisher Sci., San Jose.B255 551.3 Gamma-ketoaldehydes modifi edphosphatidylethanolamine induces infl ammatory response viaendoplasmic reticulum stress pathway. L. Guo, Z. Chen, B.Cox, V. Amarnath, R. Epand and S. Davies. Vanderbilt Univ.and McMaster Univ., Canada.B256 551.4 Saturated fatty acid-induced activation ofproinfl ammatory pathways is fatty acid-specifi c effects not dueto the contaminants in BSA. S. Huang, R. Snodgrass, K. Ono-Moore, J. Rutkowsky, S. Adams and D. Hwang. USDA, Davisand Univ. of California, Davis.B257 551.5 Prevention of HIV protease inhibitor-inducedER stress and infl ammatory response by pitavastatin inmacrophages. Y. Huang, F. Wang, X. Li, E. Studer, P.B.Hylemon, W.M. Pandak and H. Zhou. Virginia CommonwealthUniv., Sch. of Pharm., Wenzhou Med. Col. and Shandong Univ.,People’s Republic of China and Hunter Holmes McGuire VAMed. Ctr., Richmond.B258 551.6 The novel function of SREBP-1a in pathogenicdefense mechanism of macrophages. S-S. Im, L. Yousef, C.Blaschitz, J.Z. Liu, R.A. Edwards, D. Fraser, S.G. Young, A.Tenner, M. Raffatellu and T.F. Osborne. Sanford-BurnhamMed. Res.Inst., Orlando, Univ. of California, Irvine and UCLA.B259 551.7 Crucial role of the leukotriene B4 receptorBLT2 in epidermal wound healing. M. Liu, K. Saeki, Y. Abe andT. Yokomizo. Kyushu Univ., Japan.B260 551.8 Utilizing a lipidomic approach forcharacterization of eicosanoids in ceramide kinase ablationmodels. J. Mietla, D.S. Wijesinghe, E.K. Mayton, N.F. Lamourand C.E. Chalfant. Virginia Commonwealth Univ. and HunterHolmes McGuire VA Med. Ctr.B261 551.9 Roles of 12-HHT/LTB4 receptor, BLT2 inmurine infl ammatory colitis T. Okuno, Y. Iizuka, K. Saeki andT. Yokomizo. Kyushu Univ. and Univ. of Tokyo.B262 551.<strong>10</strong> Comparative effect of eicosapentaenoic anddocosahexaenoic acids on neutrophil function. V.A. Paschoal,M.A. R. Vinolo and R. Curi. Univ. of São Paulo.B263 551.11 Via calcium-independent phospholipaseA 2expression after proinfl ammatory lipopolysaccharide treatmentof astrocytes results in augmented Ca 2+ signaling. G. Reiser andM. Strokin. Otto von Guericke Univ. Magdeburg, Germany.B264 551.12 Generation of monoclonal antibodies specifi cfor mouse leukotriene B4 receptor 1 and N-terminal fl agsequence. F. Sasaki, K. Saeki, T. Okuno and T. Yokomizo.Kyushu Univ., Japan.B265 551.13 Substrates bound to the cyclooxygenase-2homodimer exhibit alternate conformations per monomer. A.J.Vecchio and M.G. Malkowski. Univ. at Buffalo, SUNY andHauptman-Woodward Med. Res. Inst., Buffalo.B266 551.14 The role of C/EBP homologous protein in HIVprotease inhibitor-induced dyslipidemia. Y. Wang, L. Zhang,E. Studer, P.B. Hylemon, W.M. Pandak and H. Zhou. VirginiaCommonwealth Univ., China Pharmaceut. Univ. and HunterHolmes McGuire VA Med. Ctr., Richmond, VA.B267 551.15 A lipidomics approach towards understandingeicosanoid signaling events and the role of ceramidekinase during the wound healing process. D.S. Wijesinghe,M. Brentnall, L.H. Boise and C.E. Chalfant. VirginiaCommonwealth Univ., Hunter Holmes McGuire VA Med. Ctr.,Richmond, Emory Univ. Sch. of Med. and Univ. of Miami MillerSch. of Med.B268 551.16 The potential for a soy phosphatidylglycerolbasedtopical treatment for psoriasis. D. Xie, R. Podolsky,M. Seremwe, J.G. Edwards and W.B. Bollag. Med. Col. ofGeorgia and Charlie Norwood VA Med. Ctr. and ApeliotusTechnol. Inc., Atlanta.B269 551.17 The dietary isothiocyanate, sulforaphane,suppresses microsomal prostaglandin E synthase 1 byregulating hypoxia-inducible factor 1 alpha J. Zhou, J.V. Crossand D.J. Templeton. Univ. of Virginia Sch. of Med.552. NON-ANIMAL GENETIC MODELS OF LIPIDMETABOLISMPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:25 PM-1:55 PMBIOCHEMISTRYB270 552.1 Characterization of glycerophosphodiestertransport in the pathogenic yeast, Candida albicans. A.C.Bishop, T. Sun, M.E. Johnson and J. Patton Vogt. DuquesneUniv.B271 552.2 Neurofi bromin homologs IRA1 and IRA2impinge upon phospholipid metabolism in Saccharomycescerevisiae. K. Rosiek, B. Surlow, A. Bishop and J. Patton-Vogt. Duquesne Univ.B272 552.3 The role of the B-type phospholipases incellular stress events in S. cerevisiae. B.A. Surlow, T. Sun andJ. Patton-Vogt. Duquesne Univ.SUN151
BIOCHEMISTRY553. NUCLEAR LIPID SIGNALINGPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:25 PM-1:55 PMB273 553.1 The transcriptional activation of melanocortin2 receptor accessory protein by PPARγ2 in murine adipocyte.S.H. Kim and N.S. Kim. Kyung Hee Univ., South Korea.554. PHARMACOLOGICAL TARGETS IN LIPIDMETABOLISMPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:25 PM-1:55 PMB274 554.1 The transmembrane domain region of the betasubunit of the organic solute transporter alpha-beta is essentialfor heterodimerization with the alpha subunit. W.V. Christian,N. Li and N. Ballatori. Univ. of Rochester.B275 554.2 Phosphatidylcholine biosynthesis in plants andnematodes: biochemical and thermodynamic characterizationof phosphoethanolamine methyltransferases. S-G. Lee andJ.M. Jez. Washington Univ. in St. Louis.B276 554.3 A proteomic approach to analysis of functionaleffects of fatty acids on NIH3T3 fi broblasts. J. Magdalon, E.Hatanaka, T. Romanatto, C. Scaife, P. Newsholme and R.Curi. Univ. of São Paulo, Univ. Cruzeiro do Sul, Brazil andUniversity Col. Dublin.B277 554.4 Is valproate’s brain target in treating bipolardisorder an arachidonic acid selective acyl-CoA synthetase?H.R. Modi, J.A. Shimshoni, M. Basselin, L.O. Li, R.A.Coleman and S.I. Rapoport. NIA, NIH, Univ. of Washingtonand Univ. of North Carolina at Chapel Hill.B278 554.5 Susceptibility of two Gram-positive pathogensto fatty acid synthesis inhibitors. J. Parsons, M. Frank, C.Subramanian and C.O. Rock. St. Jude Children’s Res. Hosp.B279 554.6 Skin antibacterial defense by fatty acidintoxication. J. Yao, M. Frank, J.B. Parsons and C.O. Rock.St. Jude Children’s Res. Hosp.555. GLYCOBIOLOGY AND EXTRACELLULARMATRIXPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:25 PM-1:55 PMB280 555.1 Microvesicles from various sources displaya common glycomic signature. B.S. Batista, W. Eng, M.Abramczuk and L.K. Mahal. Univ. of Texas at Austin andNYU.B281 555.2 Changes in extracellular macromoleculesand oxidative stress biomarkers during degradation of pyreneand phenanthrene by Micrococcus sp. and Pseudomonasputida. M.N. Igwo-Ezikpe, G.O. Gbenle, J. Okpuzor and A.A.Osuntoki. Univ. of Lagos, Nigeria.B282 555.3 Trypanosoma cruzi regulates the extracellularmatrix interactome network to gain cellular entry. C.A.Johnson, P.N. Nde, T.C. Cardenas, S. Pratap, V. Furtak, Y.Kleshchenko, M.F. Lima and F. Villalta. Meharry Med. Col.B283 555.4 Fibronectin in the ocularlens. M. King, Y. Wang and M.K. Duncan. Univ. of Delaware.B284 555.5 Preparation of a meningococcal group cpolysialic acid-tetanus Hc fragment glycoconjugate vaccinecandidate by chemoenzymatic synthesis. P. McCarthy, R.Saksena, D.C. Peterson, J. Vionnet and W.F. Vann. FDA,Bethesda.B285 555.6 Infl uence of copper in the pattern of genesinvolved in the interaction of Paracoccidioides brasiliensiswith the extracellular matrix component. H.C. Oliveira, M.T.Matsumoto, J.F. Silva, C.M. Marcos, A. C.A. Silva, A.M.Fusco-Almeida, C.M. Soares and M. J.S. Mendes-Giannini.Fed. Univ. of São Paulo, Araquara and Fed. Univ. of Goiás,Brazil.B286 555.7 The core-1 O-glycans of Microbacteriumnematophilum-resistant Caenorhabditis elegans bus-4 mutantsare altered. M. Rahman, E. Jankowska, J. Hodgkin, D.O’Rourke and D. Stroud. FDA, Bethesda and Univ. of Oxford.B287 555.8 Antithetic glypican control of cancer growthand dissemination. S. Rossi, E. Garusi, A. D’Angelo, C. Alias,P.A. Nicolosi, L. Borsi, E. Balza, R. Gatti, G. Gobbi, M. Vitaleand R. Perris. Univ. of Parma, Natl. Tumor Inst., Aviano andNatl. Cancer Res. Inst., Genoa.B288 555.9 A fully automated workfl ow for glycopeptideanalysis. J. Saba, R. Viner, P. Shan, L. Xin, C. Wigmore and B.Delanghe. Thermo Fisher Scientifi c, San Jose, BioinformaticsSolutions Inc., Waterloo, Canada and Thermo Fisher Scientifi c,Bremen, Germany.B289 555.<strong>10</strong> Differentially expressed proteins inParacoccidioides brasiliensis involved in extracellular matrixadhesion. J.F. Silva, H.C. Oliveira, C.M. Marcos and M. J.S.Mendes-Giannini. Fed. Univ. of São Paulo, Araraquara.556. GLYCANS IN DEVELOPMENT AND DISEASEPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:25 PM-1:55 PM<strong>SUNDAY</strong>B290 556.1 Is DPMS a contributing factor in tunicamycininducedunfolded protein response and shuts down tumorangiogenesis? K. Baksi, A. Banerjee, L.A. Espinoza, M.D.Suleiman, M. Torres, D.V. Rodriguez, A. Aboukheir, J.S.Placido, Z. Zhang and D.K. Banerjee. Univ. Central del Caribe,PR, Univ. of Puerto Rico and Inst. of Funct. Nanomaterials, RioPiedras, PR.B291 556.2 Hyaluronan-mixed esters of butyric and retinoicacid act transcriptionally on cardiac fi broblasts decreasingmyocardial scarring in infarcted hearts. C. Cavallini, R.Tassinari, F. Bonavita, V. Lionetti and C. Ventura. Univ. ofBologna and Scuola Superiore S. Anna, Pisa.B292 556.3 Sugar effects on microdissected cellularinteractions. H. Davoudi, C. Coyle-Thompson and S.B.Oppenheimer. California State Univ., Northridge.B293 556.4 Lectin effects on microdissected cellularinteractions. H. Davoudi, C. Coyle-Thompson and S.B.Oppenheimer. California State Univ., Northridge.152
<strong>SUNDAY</strong>B294 556.5 Characterization of binding specifi city antiglycanmonoclonal antibody, L6B8, generated from splenocytesof Schistosoma mansoni-infected mice C. Demalo, M.Mandalasi, C. Marrero-Reviera, R.D. Cummings and A.K.Nyame. Univ. of Maryland Eastern Shore and Emory Univ.B295 556.6 Hyaluronan/Hyal2 signaling activates tumorsuppressors WOX1 and Smad4. F-J. Lai, L-J. Hsu, Q. Hongand N-S. Chang. Chi-Mei Med. Ctr., Tainan Cty., Natl. ChengKung Univ., Taiwan, Zhongshan Hosp., Fudan Univ., People’sRepublic of China and SUNY Upstate Med. Univ.557. PROTEIN-GLYCAN FUNCTIONALINTERACTIONSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:25 PM-1:55 PMB296 557.1 Bioactive compounds to prevent galectinmediatedmetastasis of prostate cancer. P. Guha, E. Kaptanand H. Ahmed. Univ. of Maryland Sch. of Med.558. STATUS OF JAKS AND STATS IN JAK/STATSIGNALINGPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB297 558.1 Phosphorylation of Y372 is critical for ligandmediatedJak2 tyrosine kinase activation. K. Gnanasambandan,J. Sayyah, S. Kamarajugudda, S. Tsuda, J. Caldwell-Busbyand P.P. Sayeski. Univ. of Florida and The Scripps Res. Inst.,Jupiter, FL.B298 558.2 The importance of STAT5 activation in thymicstromal lymphopoietin mediated signaling in mouse and humanT cells. Y. Rochman and W.J. Leonard. NHLBI, NIH.B299 558.3 Antiviral protection mechanisms mediated byIFNγ isoforms through 2 distinct IFNγ receptor-STAT1 signalingpathways in fi sh. T. Yabu, M. Yamashita, N. Mano, Y. Masuhiro,S. Hanazawa, H. Shiba, T. Moritomo and T. Nakanishi. NihonUniv. and Natl. Res. Inst. of Fisheries Sci., Yokohama.559. CELL DIFFERENTIATIONPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB300 559.1 Expression and functional roles of pannexin 3in odontoblast proliferation and differentiation. T. Iwamoto, M.Ono, T. Nakamura, A. Yamada, Y. Yamada and S. Fukumoto.Tohoku Univ. Grad. Sch. of Dent., Japan and NIDCR, NIH.B301 559.2 PPARγ/STAT5A pathway plays a key factor inadipogenesis of hBMSCs and 3T3-L1 preadipocytes. H. Jung,J. Kim and J. Lee. Yonsei Univ. Col. of Med. and Brain Korea21 Proj. for Med. Sci., Seoul.B302 559.3 Effects of lithium chloride and valproic acidon phospholipid composition of Tetrahymena patula. A.L.Lawrence and P.E. Ryals. Univ. of West Florida.B303 559.4 Diverse functions of Epiprofi n in ectodermalorganogenesis. T. Nakamura, S. Fukumoto and Y. Yamada.Tohoku Univ. Grad. Sch. of Dent., Japan and NIDCR, NIH.B304 559.5 Red yeast rice-garlic extract inhibitsadipogenesis by downregulating adipogenic transcriptionfactors and gene. H.J. Park, D.K. Park, S.G. Hwang, O.D.Abanto and I.S. Kim. Konkuk Univ. and Hankyong Natl. Univ.,South Korea and Univ. of Philippines Los Baños.B305 559.6 The expression of pluripotent genes in normalhuman endometrium. K.Y. Pérez, J. Hyun-Park, P.S. Tanwarand J. Teixeira. Interamerican Univ. of Puerto Rico in SanGermán and Massachusetts Gen. Hosp.B306 559.7 miR-9 regulates cell survival by targetingprotogenin during chondrogenesis. J. Song, D. Kim, J-B. Raand E-J. Jin. Wonkwang Univ. and Kyeongnam Natl. Univ. ofSci. and Technol., South Korea.B307 559.8 The effects of lithium and valproic acid onprotein phosphorylation in Tetrahymena patula. K.C. Sprinkeland P.E. Ryals. Univ. of West Florida.B308 559.9 Characterization of rabbit mesenchymal stemcells. A. Yaszemski, G.E. Rooney and A.J. Windebank. Univ.of Colorado at Colorado Springs and Mayo Clin.560. CELL PROLIFERATIONPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMBIOCHEMISTRYB309 560.1 Interaction between the Xenopus morphogeneticfactor tumorhead and its putative binding protein X-FBXO30. N.Flores and E.E. Traverso. Univ. of Puerto Rico at Humacao.B3<strong>10</strong> 560.2 Mechanism of 1,25(OH) 2-vitamin D 3-inducedgrowth inhibition of transformed endothelial cells V. GonzalezPardo, R. Boland and A.R. de Boland. Natl. Southern Univ.,Argentina.B311 560.3 Infl uence of pH and Src-family tyrosine kinaseson pulmonary fi broblasts after exposure to world trade centerparticulate matter. M.N. Hernandez, S. Choi, F. Rouf and A.M.DiLorenzo. Montclair State Univ., NJ.B312 560.4 The endocrine disruptors cadmium chloride andsodium arsenate activate estrogen receptor-mediated signalingand induce human lung adenocarcinoma cell proliferation. M.O.Huff, S.L. Todd, A.L. Smith, K.A. Riggs and C.M. Klinge.Bellarmine Univ. and Univ. of Louisville Sch. of Med.B313 560.5 Effects of distilled water exposed to spaceenergy device on various cell proliferation activity. S.G. Hwang,E.S. Shin, J.C. An, M.R. Heo and E.J. Lee. Hankyong Natl.Univ., South Korea.SUN153
BIOCHEMISTRY561. CYTOKINE AND GROWTH FACTOR SIGNALINGPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB314 561.1 Identifi cation of DNA topoisomerases inducedby interleukin-2 in HuT 78 cells. P.D. Foglesong, J. Ma, T.Jaiswal and T.A. Singh. Univ. of Incarnate Word, TX.B315 561.2 Interferon induced non-STAT dependentpathway and tumor suppression. P. Gade, U.B. Machani andD.V. Kalvakolanu. Univ. of Maryland Baltimore.B316 561.3 Structure-activity studies of competitive ligandbinding to neuropilin in angiogenesis. H-F. Guo, P. Xu, M.W.Parker and C.W. Vander Kooi. Univ. of Kentucky Col. of Med.B317 561.4 IL-1β induces FGF-2 production via PI 3-kinase/p38/NF-κB pathways in corneal endothelial cells. J.G. Lee andE.P. Kay. Doheny Eye Inst. and Keck Sch. of Med., Univ. ofSouthern California.B318 561.5 The potential of HGF and 2xInlB to activate theMet receptor and attenuate chondroitin sulfate proteoglycanexpression in astrocytes. T.T. Logan, P. Yu, H.M. Geller, O.Mungunsukh, R.M. Day and A.J. Symes. Uniformed Svcs.Univ. of Hlth. Sci., and NHLBI, NIH.B319 561.6 BDNF receptor TrkB modulates voltage-gatedK + (Kv) 1.5 channel protein expression. T.K. Makar, N.P.Nooli, V. Nimmagadda, G.K. Patibandla, R. Chakravarty,S.I. V. Judge, A. Maiti and C.T. Bever, Jr. Univ. of MarylandBaltimore.B320 561.7 Regulatory effect of CCL26 on cancer relatedgenes during infl ammation. R. Marijani, T. Mathews, H.McGann and B. Abonyo. Florida A&M Univ.B321 561.8 Organophosphates inhibit expression of growthfactors in neuroblastoma cells. T. Mathews, H. McGann, R.Marijani, N. Lamango and B. Abonyo. Florida A&M Univ.B322 561.9 Organophosphates induced A549 cell toxicityis accompanied by enhanced gene expression of infl ammatorycytokines. H. McGann, T. Mathews, R. Marijani, N. Lamangoand A. Barack. Florida A&M Univ.B323 561.<strong>10</strong> Spontaneous autoactivation of the EGFreceptor induced by mutations in its C-terminal negativelycharged residues. H. Miyagi, A.S. Adenan, Z. Taoufiq and I.N.Maruyama. Okinawa Inst. of Sci. and Technol.B324 561.11 Exogenous and autocrine growth hormoneaffect LNCaP prostate cancer cell proliferation, survival andmotility A.O. Nakonechnaya, X. Chen, R.F. Overcash, H.S.Jefferson and B.M. Shewchuk. East Carolina Univ.B325 561.12 Transforming growth factor beta in inducedsputum and whole blood in cystic fi brosis. S. Schmitt-Grohé,L. van den Boom, D. Ngampolo, O. Eickmeier, R. Schubert,S. Zielen and M.J. Lentze. Univ. Hosp. Bonn and Univ. Hosp.Frankfurt.B326 561.13 Role of fi sh IFNγ-related gene in immunesystem. Y. Shibasaki, T. Yabu, T. Moritomo and T. Nakanishi.Nihon Univ. Col. of Bioresource Sci., Japan.B327 561.14 The functional association between fi lamin Band histone deacetylase 7 in endothelial cells. Y-T. Su, C. Gao,Y. Liu, P. Tempst, H. Erdjument-Bromage and H-Y. Kao. CaseWestern Reserve Univ. and Mem. Sloan-Kettering Cancer Ctr.B328 561.15 PAPP-A and IGFBP-4 in abmormal pregnancysera. O.A. Vanderpuye. Albany State Univ.B329 561.16 Interleukin-13 (IL-13)/IL-13 receptor α1signaling regulates intestinal epithelial cystic fi brosistransmembrane conductance regulator channel-dependent Cl -secretion. D.X. Y. Wu, R. Ahrens, H. Osterfeld, K. Groschwitz,P. Foster, M.E. Rothenberg, K.I. Matthaei, F.D. Finkelmanand S.P. Hogan. Cincinnati Children’s Hosp. Med. Ctr., Univ.of Newcastle, Australia and John Curtin Sch. of Med. Res.,Canberra.B330 561.17 Transforming growth factor β signaling inducescysteine-rich protein 2 expression in vascular smooth musclecells. S-F. Yet, M-L. Wu and Y-J. Jheng. Natl. Hlth. Res. Inst.,Zhuman, Taiwan.562. IMMUNE CELL SIGNALINGPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PM<strong>SUNDAY</strong>B331 562.1 Enhanced T cell signaling in cells bearingLAT molecules resistant to ubiquitylation. L. Balagopalan, B.Ashwell, K. Bernot, I. Akpan, N. Quasba, V. Barr and L.E.Samelson. NCI, NIH.B332 562.2 Mitogen-activated protein kinase kinase kinase(MAP3K) and GTPase activity in human natural killer cellsexposed to dibutyltin. L. Celada and M.M. Whalen. TennesseeState Univ.B333 562.3 Expression of P2X7 receptor splice variants isdifferentially regulated in macrophages versus T lymphocytesand is modulated by infl ammatory cytokines. D.M. Chopyk, J.Robinson, K. Trueblood and G.R. Dubyak. Case WesternReserve Univ.B334 562.4 mAb BGD6, a mast cell lineage marker, bindsto a 1<strong>10</strong>kDa protein unrelated to FcεRI E.Z. M. Da Silva, M.C.Jamur and C. Oliver. Fac. of Med. of Ribeirão Preto, Univ. ofSão Paulo.B335 562.5 Conditional deletion reveals a role for Sos1 inpre-TCR signaling and thymocyte development. R.L. Kortum,C.L. Sommers, C.P. Alexander, J.M. Pinski, N.N. Nath, A.Grinberg, P.E. Love and L.E. Samelson. NCI and NICHD,NIH.B336 562.6 TAK1 signaling is essential for macrophagesurvival. S.R. Mihaly and J. Ninomiya-Tsuji. North CarolinaState Univ.B337 562.7 A novel role for hydrogen sulfi de: enhancementof T-cell activation/proliferation and its regulation bythrombospondin-1/CD47. T.W. Miller, E.A. Wang, S. Gould,E.V. Stein and D.D. Roberts. NCI, NIH and George WashingtonUniv.B338 562.8 Activation of protein kinase D is part of the NKcell signaling pathway activated in the tumor-cell destroyingprocess. K. Rana and M.M. Whalen. Tennessee State Univ.B339 562.9 The brominated fl ame retardantshexabromcylododecane and tetrabromobisphenol a decreasesecretion of interferon gamma from human natural killer cells.J. Reid and M.M. Whalen. Tennessee State Univ.B340 562.<strong>10</strong> Complex nano-scale organization and role ofLAT signaling complexes resolved at the single molecule level.E. Sherman, V. Barr, S. Manley, G. Patterson, L. Balagopalan,I. Akpan, C.K. Regan, J. Lippincott-Schwartz and L.E.Samelson. NCI and NICHD, NIH.154
<strong>SUNDAY</strong>B341 562.11 Novel role of the transcriptional regulator HIF-1α in the antimicrobial activity of mast cells. M. von Köckritz-Blickwede, K. Branitzki-Heinemann, C. Okumura, H. Naimand V. Nizet. Univ. of Vet. Med. Hannover, Helmholtz Ctr. forInfect. Res., Helmholtz, Germany and UCSD Sch. of Med.B342 562.12 Tetrabromobisphenol A activates mitogenactivatedprotein kinases in human natural killer cells. M.M.Whalen and E.C. Kibakaya. Tennessee State Univ.563. SIGNALING IN DISEASE AND THERAPYPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB343 563.1 Investigation of calcineurin B homolgous protein2 regulation on NHE1: a potential novel therapeutic target totreat non-small cell lung cancer. K. Anderson, A. Slusser, J.Provost and M. Wallert. Minnesota State Univ. Moorhead.B344 563.2 The effect of selective antihypertensive drugson the vascular remodeling-associated hypertension: insightsfrom a profi lin1 transgenic mouse model. M.D. H. Hassona,M.T. Elnakish, Z.A. Abouelnaga, M.A. Alhaj, A.A. Wani andH. Hassanain. Ohio State Univ.B345 563.3 Depolarization-induced slow calcium transientsstimulate neuregulin-1β expression in dystrophic skeletalmuscle cell lines. N. Juretic, G. Jorquera, E. Jaimovich andN. Riveros. Univ. of Chile.B346 563.4 Anti-platelet and anti-thrombotic effects ofselective estrogen receptor modulator tamoxifen. M.K. Nayak,S.K. Singh, A. Roy, V. Prakash, A. Kumar and D. Dash.Banaras Hindu Univ., India.B347 563.5 Molecular and biochemical characterization ofmouse Ellis Van Creveld protein. O.O. Odunuga, A. Monsivais,S.A. Bollinger, K. Choi and E.I. Polvadore. Stephen F. AustinState Univ., TX.B348 563.6 Activated Cdc42 kinase is a cell survival signalin Drosophila melanogaster. J.A. Schoenherr, J.S. Martinez,M.R. Chikka and J.C. Clemens. Purdue Univ.B349 563.7 Glucocorticoids promoteTGF-beta signaling inlung fi broblasts by upregulating ligand and receptor expression,and uncoupling negative-feedback inhibition J.T. Schwartze,N. Kneidinger, W. Seeger and R.E. Morty. Univ. of Giessen,Germany.B350 563.8 C16-ceramide analog combined with Pc4 photodynamic therapy evokes enhanced total ceramideaccumulation, promotion of DEVDase activation in the absenceof apoptosis, and augmented overall cell killing D. Separovic,Z. Saad, E. Edwin, J. Bielawski, J. Pierce, E. Van Buren andA. Bielawska. Wayne State Univ. and Med. Univ. of SouthCarolina.B351 563.9 Phosphorylation of Crk at tyrosine 251 in theRT loop of the SH3C domain downstream of EGFR: novel rolein Abl transactivation. G. Sriram, C. Reichman, K. Machida, B.Mayer, C. Kalodimos and R.B. Birge. UMDNJ, Newark, Univ.of Connecticut Hlth. Ctr. and Rutgers Univ., Piscataway.B352 563.<strong>10</strong> The role of marinobufagenin in the causationof a cerebral vascular leak syndrome in a rat model of humanpreeclampsia. M.N. Uddin. Texas A&M Hlth. Sci. Ctr., Temple.B353 563.11 The application of an innate immune agonistin the treatment of ovarian cancer. D.N. Van, C.F. Roberts, S.Lepine and J.K. Bell. Virginia Commonwealth Univ.B354 563.12 Mesenchymal stem cells provide protection ofcardiac ventricular myocytes by paracrine mechanism. R.D.Wardlow II, S. Gaa, D. Riley, W.J. Lederer and T.B. Rogers.Univ. of Maryland Sch. of Med.B355 563.13 Survivin inhibition is critical for Bcl-2 familyinhibitor, ABT-263 to induce apoptosis in liver cancer cells X.Zhao, O. Ogunwobi, D.R. Nelson and C. Liu. Univ. of Florida.564. TRANSCRIPTIONAL REGULATIONPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMBIOCHEMISTRYB356 564.1 Alcohol-mediated decrease in Krüppel-liketranscription factor 4 and its effects on zinc levels in alveolarcells. T.V. Curry-McCoy, D.M. Guidot and P.C. Joshi. EmoryUniv. and VA Med. Ctr., Decatur.B357 564.2 A rapid assay for affi nity and kinetics of DNAproteininteractions. G.P. Donaldson and V.T. Lee. Univ. ofMaryland College Park.B358 564.3 Study of human μ-opioid receptor gene. Y.M.Esteban, L. Rasmussen and J.L. Ko. Seton Hall Univ.B359 564.4 The transcriptional regulation ofN-acetylglutamate synthase and a mutation in the enhancerof the NAGS gene. S.K. Heibel, N. AhMew, I. Nissim, M.Yudkoff, M. Tuchman and L. Caldovic. Children’s Natl. Med.Ctr., Univ. of Maryland College Park and Children’s Hosp. ofPennsylvania.B360 564.5 Expression and purifi cation of an irondependentregulator protein from Thermobifi da fusca. J.J.Hoerr, Z. Lu, J.N. Grow and W.R. P. Novak. Wabash Col.B361 564.6 Functional characterization of a novel BTB/POZ-domain protein ZBTB8A. M-K. Kim, B-N. Jeon and M-W.Hur. Yonsei Univ. Sch. of Med., South Korea.B362 564.7 Mechanism and specifi city of humanmitochondrial transcription factor A binding to the light-strandpromoter. N. Kumar and C.E. Cameron. Penn State.B363 564.8 Analysis of urea cycle gene transcriptionregulation using bioinformatic software and patient sequences.A.L. LaBella, T. Feeney, S.K. Heibel, M. Tuchman and L.Caldovic. Children’s Natl. Med. Ctr., Univ. of Maryland Med.Sch. and Univ. of Maryland College Park.B364 564.9 Differential regulation of human mitochondrialpromoters by transcription factor A. M.F. Lodeiro, T. Shutt,A. Uchida, G. Shadel and C. Cameron. Penn State and YaleUniv. Sch. of Med.B365 564.<strong>10</strong> Rac1 attenuates macrophage MMP-9 geneexpression via inhibition of SP-1 at S586. S. Murthy, A.J. Ryanand A.B. Carter. Univ. of Iowa.B366 564.11 Varied mechanisms of estradiol mediatedregulation of dopamine beta-hydroxylase gene transcription. R.Nostramo, L.I. Serova and E.L. Sabban. New York Med. Col.B367 564.12 Evidence for the dynamic association ofproteins with RNA polymerase I. L.I. Rothblum, P. Yvonne andK. Rothblum. Univ. of Oklahoma Col. of Med.B368 564.13 Expression of PP1γ1 and PP1γ2 in testiculargerm cells and Sertoli cells, respectively, is required for normalspermatogenesis N. Sinha, P. Puri and S. Vijayaraghavan.Kent State Univ. and Univ. of Pittsburgh.SUN155
BIOCHEMISTRY565. MAP KINASESPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB369 565.1 Role of p44/42 activation in DBT-induced lossof cytotoxic function of human natural killer cells. A.B. Abrahaand M. Whalen. Tennessee State Univ.B370 565.2 Atypical MAPK ERK3 is required for thedevelopment of interstitial fi brosis during pressure overloadinducedhypertrophy. D. Dingar, Y. Shi, M-A. Gillis, M. Gaestel,S. Meloche, J-C. Tardif and B.G. Allen. Montral Heart Inst.,Univ. of Montreal and Med. Sch Hannover.B371 565.3 Cloning and expression of parasitic mitogenactivatedprotein kinase. J.H. Dyer, K. Gaskill and J. Siekierka.Montclair State Univ., NJ.B372 565.4 Expression, phosphorylation, and localizationof the novel B-RAF target FAM129b/MINERVA in humanmelanoma and breast epithelial cells J.C. Riedinger, M. Pytlik,J. Brule, T. Anderson and J.B. Shabb. Univ. of North Dakotaand Concordia Col., MN.B373 565.5 Role of Bam32 in TCR-induced Erk activation.A.K. Rouquette-Jazdanian, I. Akpan, V. Barr, C.L. Sommersand L.E. Samelson. NCI, NIH.B374 565.6 Cytokine gene expression and ERK activationis modulated by PP2A in THP1 cells exposed to asbestos. A.J.Ryan and A.B. Carter. Univ. of Iowa.B375 565.7 Oxidative inhibition of MAPKAP kinase 2 ispredominately mediated through the activation loop cysteine.E.A. Rye, B. Forsberg, A. Johansen, R. Patel, C. Schumacherand C.A. Chrestensen. Kennesaw State Univ.B376 565.8 ATP-dependent crosstalk between c-JunN-terminal kinase and ERK/Akt determines survival of cardiacmyocytes subjected to hypoxia-reoxygenation. W. Wang, H. Liand K. Webster. Univ. of Miami.566. SERINE/THREONINE KINASEPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB377 566.1 Mechanisms regulating the nuclear localizationof p90 ribosomal S6 kinase1. X. Gao and T. Patel. Loyola Univ.Chicago, Maywood.B378 566.2 Saccharomyces cerevisiae Env7p is a vacuolarintegral membrane protein and an orthologue of human ser/thrkinase STK16. E. Gharakhanian, S. Manandhar, S. Cocca,F. Ricarte and M. Serranilla. California State Univ., LongBeach.B379 566.3 Development of synthetic biologics to probe therole of D-AKAP2 in breast cancer. E.J. Kennedy, G.N. Sarma,C.T. Eggers and S.S. Taylor. Col. of Pharm., Univ. of Georgia,UCSD and HHMI, La Jolla.B380 566.4 Investigation of a potential tyrosinephosphorylation site in the activation loop of a yeast caseinkinase 1 protein kinase. L.C. Larkin, L.C. Robinson and C.Brame. Centenary Col. of Louisiana and LSU Hlth. Sci. Ctr.,Shreveport.B381 566.5 Phosphorylation site mapping and mutationalstudies of the ACR4 intracellular domain. M.R. Meyer and A.G.Rao. Iowa State Univ.B382 566.6 Ser243 in the activation loop of the Yck2 CK1protein kinase may be an inhibitory phosphorylation site. J.Phillips, L. Larkin, L. Robinson and C. Brame. CentenaryCol. of Louisiana and LSU Hlth. Sci. Ctr., Shreveport.567. TYROSINE KINASESPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB383 567.1 Characterization of kinase inhibitors using akinase binding assay on active/inactive TrkA/TrkB and a TrkBassay in neurons. L. De Vries, F. Finana, I. Rauly-Lestienne,F. Lestienne, M-C. Ailhaud and D. Cussac. Pierre Fabre Res.Ctr., Castres, France.B384 567.2 Combining chemical rescue and proteomics togain a better understanding of the cellular role of the c-Src protooncogene.M.I. Martinez Ferrando, H. Molina, R. Chaerkady,J. Zhong, H.K. C. Jacob, A. Pandey and P.A. Cole. JohnsHopkins Sch. of Med. and Ctr. for Genomic Regul., Barcelona.B385 567.3 Regulation of growth factor receptor degradationby ADP-ribosylation factor-domain protein 1. V. Meza-Carmen,G. Pacheco-Rodriguez, J. Kato, G.S. Kang, C. Donati, A.Vichi, C. Zhang, M. Payne, S. El-Chemaly, J. Moss and M.Vaughan. NHLBI, NIH.B386 567.4 Diversity in the control of individual Src-familykinases by their SH3 domains. J.A. Moroco, J.J. Alvarado, J.I.Yeh and T.E. Smithgall. Univ. of Pittsburgh.B387 567.5 Implication of c-Src tyrosine kinase inangiotensin II and endothelin-1-induced MAPK activation andearly growth-response factor-1 expression in vascular smoothmuscle cells. G. Vardatsikos and A.K. Srivastava. Univ. ofMontreal and Univ. of Montreal Hosp. Ctr.568. THE CHEMICAL BIOLOGIST’S TOOLBOXPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PM<strong>SUNDAY</strong>B388 568.1 Chemical site-selective modifi cation of proteins:tools for synthetic biology. G.J. L. Bernardes. Univ. of Oxford.B389 568.2 How streptavidin’s utility in bionanotechnologywas increased: pushing the limits of a non-covalent interaction.C.E. Chivers, E. Lowe and M. Howarth. Univ. of Oxford.B390 568.3 Mitochondria-targeted probes and functionalmolecules. R.C. Hartley. Sch. of Chem., Univ. of Glasgow.B391 568.4 Orthogonal dual wavelength photoactivation ofcAMP and cGMP-dependent protein kinase signaling pathways.M.A. Priestman, L. Sun and D.S. Lawrence. Univ. of NorthCarolina at Chapel Hill Eshelman Sch. of Pharm.B392 568.5 H NMR spectra of substituted phenyl succinamicacids: a case study of deceptive simplicity. J.M. Risley, A.M.Young, J.P. Kastanis, J.A. Stanziale and R. Zohby. Univ. ofNorth Carolina at Charlotte.156
<strong>SUNDAY</strong>569. CHEMICAL PROBES AND THEIR USE INIDENTIFYING NEW THERAPEUTIC TARGETSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB393 569.1 Development of bifunctional small moleculesas chemical tools and potential therapeutics for Alzheimer’sdisease. J-S. Choi and M.H. Lim. Univ. of Michigan.B394 569.2 Sterol-hydrazone derivatives as inhibitorsof the fungal Δ24-sterol methyl transferase. G. San-Blas, G.Visbal, J. Murgich and G. Niño-Vega. IVIC, Caracas.B395 569.3 Mechanistic studies of the antiproliferative andimmunosuppressive natural product triptolide. D.V. Titov, B.Gilman, Q-L. He, S. Bhat, W-K. Low, M. Smeaton, A. Demain,P. Miller, J. Kugel, J. Goodrich and J.O. Liu. Johns HopkinsUniv. Sch. of Med., Univ. of Colorado at Boulder, Johns HopkinsUniv. Bloomberg Sch. of Publ. Hlth. and Drew Univ., NJ.570. HIGH-CONTENT APPROACHESPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB396 570.1 Engineered heart tissues in high-throughputtoxic compound screening. V. Rufanova, W. Baehr, M. Gerger,A. Badic and T. Wakatsuki. InvivoSci. LLC, Wauwatosa, WIand Med. Col. of Wisconsin.571. NEW SPECTROSCOPIC TECHNIQUES FORCHEMICAL BIOLOGISTSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB397 571.1 Pathways to natural organochlorine formationin decaying plant material: a novel assay. L. Herren and A.Leri. Marymount Manhattan Col.572. PROTEIN-SMALL MOLECULE INTERACTIONSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB398 572.1 Structure activity relationships of para- andmeta-hydroxyl derivatives of the Jak2 inhibitor G6: signifi canceof the para-hydroxyl conformation. R. Baskin, A. Majumder,C. Fuhrman, M. Gali, K.S. Bisht and P.P. Sayeski. Univ. ofFlorida and Univ. of South Florida.B399 572.2 Molecular dynamics study of furanose bindingprotein. B. Dow and J. Rhoad. Missouri Western State Univ.B400 572.3 Aminoglycoside phosphotransferasescatalyze the formation of an inhibitor of the DWI/SNF familyof DNA-dependent ATPases. P. Dutta, S.S. Komath and R.Muthuswami. Sch. of Life Sci., Jawaharlal Nehru Univ., India.B401 572.4 Identifi cation of residues involved in ligandbinding specifi city in the dihydrofolate reductase family. S.M.Hall, N. Goodey, K. Herbert and H. Obeidallah. MontclairState Univ., NJ.B402 572.5 Structural insights for aminoglycoside-inducednephrotoxicity: molecular modeling studies of the calreticulingentamicincomplex. G. Hariprasad, U. Das, M. Kumar, P.Kaur, T.P. Singh and A. Srinivasan. All India Inst. of Med. Sci.,New Delhi.B403 572.6 Carnosine promotes GAPDH dimer formation:proposed role in preventing neurodegeneration. J.Y. Kim andN.W. Seidler. Kansas City Univ. of Med. and Biosci.B404 572.7 A mutant of platelet-activating factoracetylhydrolase hydrolyzes the nerve agent soman. S. Kirby,J. Norris, D.M. Cerasoli and B. Bahnson. U.S. Army Med.Res. Inst. of Chem. Def., Aberdeen Proving Ground, MD andUniv. of Delaware.B405 572.8 Structure-based insight into the mechanism oftype I dehydroquinate dehydratases. S.H. Light, G. Minasov,M-E. Duban, L. Shuvalova, M. Caffrey, A. Lavie and W.F.Anderson. Northwestern Univ., Chicago and Univ. of Illinois atChicago.B406 572.9 NMR studies reveal unexpected binding sitefor APE1 redox inhibitor. B. Manvilla, O. Wauchope, K. Seley-Radtke and A.C. Drohat. Univ. of Maryland Baltimore andUniv. of Maryland Baltimore County.B407 572.<strong>10</strong> Construction and validation of a random 21-mer phage-peptide library. Y. Yamamoto, S. Shah, E. Yoderand A.G. Rao. Iowa State Univ. and Maple Valley Anthon OtoH.S., Mapleton, IA.B408 572.11 Selection and characterization of peptidesbinding with high affi nity to metal ions using a 21-mer randomphage-displayed peptide library. Y. Yamamoto and A.G. Rao.Iowa State Univ.573. SMALL MOLECULE TOOLS FOR BIOLOGYPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMBIOCHEMISTRYB409 573.1 Effects of polynitrogen compounds on theactivity of recombinant human hypoxia inducible factor -1αprolylhydroxylase 3 in Escherichia coli. Z. Geng, J. Cao, X. Ma, C. Liand Z. Wang. Sch. of Chem. and Chem. Engin., Nanjing Univ.,People’s Republic of China.B4<strong>10</strong> 573.2 Exploring the effi cacy of small moleculeinhibitors of AKAP-PKA interactions. M.C. Moutty, K. Zühlke,J. Milic, V. Tabor, A. Goncalves, C. Noack, F. Christian, S.Grossmann, J.P. von Kries, W. Rosenthal and E. Klussmann.Leibniz Inst. for Molec. Pharmacol., Max-Delbrück-Ctr. forMolec. Med. and Charité Univ. Med. Berlin.SUN157
BIOCHEMISTRY574. TARGET IDENTIFICATION AND PATHWAYMININGPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB411 574.1 Fortilin accelerates atherosclerosis in LDLR-Apobec1 double knockout mice. K. Fujise, D. Pinkaew, R. Le,E. Vu, Y. Chen and B. Teng. Univ. of Texas Med. Branch andUniv. of Texas Hlth. Sci. Ctr. at Houston.B412 574.2 Endoreduplication induced by a novel family ofDNA topoisomerase II inhibitors. C.P. Rios-Luci, L.G. León, E.Pérez-Roth and J.M. Padrón. Univ. of La Laguna, Spain.575. CLASSROOM OF THE FUTURE I: CLASSROOMMANAGEMENT SKILLSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCCareer Development and EducationPresentation time: 1:05 PM-2:35 PMB413 575.1 Educational uses of molecular visualization:a survey of the community. P.A. Craig, L.V. Michel and R.C.Bateman. Rochester Inst. of Technol. and Univ. of SouthernMississippi.B414 575.2 Using pre-postassessment data to investigateincorrect ideas that students bring to undergraduate biochemistrycourses. J. Loertscher, V. Minderhout, S. Villafane and J.Lewis. Seattle Univ. and Univ. of South Florida.B415 575.3 Comparison kinetics of Escherichia coliβ-galactosidase using a microplate reader and a Genosys 5spectrophotometer. M. Soundararajan and R. Bundy. Univ. ofNebraska-Lincoln.576. CLASSROOM OF THE FUTURE II: MENTORINGSTUDENTS IN THE RESEARCH LABORATORYPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB416 576.1 Finding LUCA, Buffalo high school studentstrace the origin of the genetic code W.L. Duax, R. Huether andD. Dziak. Hauptman-Woodward Inst., Buffalo.B417 576.2 Graduate science mentoring practices, andaspects of mentor-mentee interaction: learning from Japan,Singapore, and Taiwan C. Garza-Gongora, R. Ynalvez, M.A.Ynalvez, J. Kilburn and N. Hara. Texas A&M Intl. and IndianaUniv.B418 576.3 Undergraduate research in the genomicseducation partnership: a comparative genomics projectexploring genome organization and chromatin structure inDrosophila. A.T. Hark, C.P. Bailey, S. Parrish, W. Leung,C.D. Shaffer and S.C. R. Elgin. Muhlenberg Col., PA, Univ. ofNebraska-Lincoln, McDaniel Col., MD and Washington Univ.577. FOSTERING STUDENT ENGAGEMENT IN THECLASSROOMPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB419 577.1 Foundational concepts for the molecular lifesciences. M.M. Cox. Univ. of Wisconsin-Madison.B420 577.2 Teaching biochemistry to medical professionalstudents through engaging exercises. D.M. Dean, E.G.Anderson and M. Sweezy. Saint Joseph Col., CT.B421 577.3 When reduction leads to expansion part 2: ongoingundergraduate laboratory investigations on the roles ofdisulfi de bonds within E. coli alkaline phosphatase. J.T. Hazzard,M.A. Koussa and M.J. Cornelison. Univ. of Arizona.B422 577.4 Enhanced understanding of biofuels throughproject-based and service learning in an undergraduatemolecular biology course. V.P. Miller, J.B. Jones and R.L.Waikel. Eastern Kentucky Univ.B423 577.5 Rethinking the undergraduate introductoryneurobiology course: a path to student-centered learning. M.Rosenberg and M.C. Staples. Univ. of New Mexico.B424 577.6 Analogies for enhancing understanding ofallele dominance. R. Seipelt. Middle Tennessee State Univ.B425 577.7 Lessons learned through literary classics: thebiochemistry found in Alice in Wonderland. V. Shende andM.A. Benore. Univ. of Michigan Dearborn.B426 577.8 Teaching lipids and membranes in theclassroom and laboratory. R.V. Stahelin. Indiana Univ. Sch. ofMed.-South Bend and Univ. of Notre Dame.B427 577.9 Another day at the beach and bench: education,outreach and biochemistry in the summer — the role of RhoAkinase in NHE1 activation. V. Welke, S. Richter, K. Melgaard,D. Jonason, K. Engel, D. Hammes, J. Provost and M. Wallert.Detroit Lakes H.S., MN and Minnesota State Univ. Moorhead.578. MENTORINGPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PM<strong>SUNDAY</strong>B428 578.1 Characterization of microRNA-<strong>10</strong>b in humanglioblastoma. M. Alvarado-Velez, F. Guessous and R.Abounader. Univ. of Puerto Rico and Univ. of Virginia.B429 578.2 The importance of mentoring in balancingwork/family responsibilities. S.L. Planey, D.J. Dean, E. Bowersand C. Simpson. The Commonwealth Med. Col., PA, Assn. forWomen in Sci., Alexandria, VA and Johns Hopkins Univ. Sch.of Med.158
BIOCHEMISTRY/NUTRITION579. NOVEL APPROACHES TO EXPERIMENTALLEARNINGPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB430 579.1 An introductory exercise in molecularepidemiology: investigating human rhinovirus prevalence andgenetics in a university population. C. Albright and D.J. Hall.Lawrence Univ., WI.B431 579.2 Developing and sustaining scientifi c softwareapplications for biochemistry education. A. Fisher, K. Deweyand P. Craig. Rochester Inst. of Technol.B432 579.3 Examining albumin’s esterase activity for usein the biochemistry teaching laboratory. M. King, H. Turner andB.D. Caldwell. Missouri Western State Univ.B433 579.4 Pancreatic lipase: enzyme biochemistry fromthe health food store. W.A. Patton, C.L. Delaney and R. Carr.Lebanon Valley Col., PA.B434 579.5 Protein origami: modeling secondary structurehydrogen bonding by paper folding. M. Pikaart. Hope Col., MI.580. OUTREACH AND SERVICE LEARNINGPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PM<strong>SUNDAY</strong>B435 580.1 Symbiotic methodologies in career developmentusing K-12 outreach for science education. C.J. McCormick.Tennessee Technol. Univ.B436 580.2 Dual credit general chemistry: a modeluniversity-high school collaborative effort. J.L. Torres y Torres,M.W. Ducey and B.D. Caldwell. Missouri Western State Univ.Nutrition581. DIETARY BIOACTIVE COMPONENTSINCLUDING BOTANICALSPoster(Sponsored by: Dietary Bioactive Components RIS)SUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-1:45 PM (I); 1:45 PM-2:45 PM (II)A1 I 581.1 Spectral fi ngerprints for chemicaldifferentiation of botanical materials. J. Harnly, P. Chen and D.Luthria. USDA, Beltsville.A2 II 581.2 Metabolomics analysis of grainsamples. S.S. Jonnalagadda, D.P. Lee and R. Menon. GeneralMills Bell Inst., Golden Valley, MN and Metabolon, Durham,NC.A3 I 581.3 Infl uence of grinding methodology,particle size, and on the assay of phenolic phytochemicals fromfi ve different wheat cultivars D. Luthria, A. Memon, P. Fuerstand C.F. Morris. USDA, Beltsville, Natl. Ctr. of Excellence inAnalyt. Chem., Jamshoro, Pakistan, Washington State Univ.and USDA, Pullman.A4 II 581.4 Laboratory-scale production oftomato carotenoids using bioengineered Escherichia coli. C-H.Lu, J-H. Choi, Y-S. Jin and J.W. Erdman, Jr. Univ. of Illinois atUrbana-Champaign.A5 I 581.5 Improving the functionality andbioactivity in wheat bran. M. Guo, K. Petrofsky, L. Zhang, P.Chen, A. Hohn, M. Youn, D. Gallaher, R. Liu, J. Faubion, M.Bunzel, L. Marquart and R. Ruan. Univ. of Minnesota, St.Paul, Cornell Univ. and Kansas State Univ.A6 II 581.6 Will rising atmospheric CO 2affectsoybean seed phytochemical composition? S. Britz. USDA,Beltsville.A7 I 581.7 Phenolic phytochemicals and seedoil characterization of Ziziphus mauritiana L. fruit grown inPakistan. A. Memon, D. Luthria, N. Memon and M. Bhanger.Natl. Ctr. of Excellence in Analyt. Chem., Jamshoro, Pakistanand USDA, Beltsville.A8 II 581.8 Dietary herbs and spices: beyondantimicrobials. N. Swift, D. Townsend, L. McMillin, B. Jamison,V. Maitin, T. Chesnut and D. Vattem. Texas State Univ., SanMarcos and VRDÜR Res. Intl., Odessa, TX.A9 I 581.9 Consumption of Sutherlandiafruescens, a South African botanical, alters in vivo bacterialclearance following an E. coli challenge in healthy mice K.Fritsche, J. Browning, Jr., C. Merle and W. Folk. Univ. ofMissouri-Columbia.A<strong>10</strong> II 581.<strong>10</strong> Reproductive and developmentaleffects of certain fl avonoids. M.N. Henderson, C.L. Keen andL. Lanoue. Univ. of California, Davis.A11 I 581.11 Dietary sources of caffeine intakeby U.S. adults in the 2001-2008 NHANES. D.R. Keast, V.L.Fulgoni III and H.R. Lieberman. Food & Nutr. Database Res.Inc., Okemos, MI, Nutr. Impact LL, Battle Creek and U.S. ArmyRes. Inst. of Envrn. Med., Natick, MA.A12 II 581.12 Feasibility of nutrient photoprotectionstudies in a three-dimensional human skin tissue model: usingalpha tocopherol. J.A. Evans, C-Y.O. Chen, J. Garlick, X-D.Wang and E.J. Johnson. USDA at Tufts Univ. and Tufts Univ.A13 I 581.13 ProstaCaid suppresses growth andinvasiveness of human prostate cancer cells. D. Sliva and J.Jiang. Methodist Res. Inst., Indianapolis and Indiana Univ.Sch. of Med.A14 II 581.14 Plasma lipid response to LPSchallenge in rats fed vitamin D2 enriched white buttonmushrooms. A.J. Weigand, D.W. Gaines, U.S. Babu, L.H.Garthoff and M.S. Calvo. FDA, Laurel, MD.159SUN
NUTRITIONA15 I 581.15 3,3’-Diindolylmethane inhibitsadipogenesis of 3T3-L1 preadipocytes by proteosomaldegradation of cyclin D1 S.G. Seo, S.H. Shin, S. Min, J.Y.Kwon, K-H. Kim, K.W. Lee and H.J. Lee. Seoul Natl. Univ.,Konkuk Univ., South Korea and Purdue Univ.A16 II 581.16 Serum 25(OH)D response to soyisofl avone supplementation in postmenopausal women.R.D. Lewis, W.W. Wong, D.B. Hausman, J.G. Fischer,F.M. Steinberg, M.J. Murray, M.A. Cramer, P. Amato, R.L.Young, S. Barnes, K.J. Ellis, R.J. Shypailo, J.K. Fraley, K.L.Konzelmann and E.O. B. Smith. Univ. of Georgia, Baylor Col.of Med., Univ. of California, Davis, No. California Fertility Med.Ctr., Roseville, Oregon Hlth. & Sci. Univ. and Univ. of Alabamaat Birmingham.A17 I 581.17 Examining the bone forming abilityof ferutinin, an extract of giant fennel, on the function ofMC3T3-E1 osteoblast-like cells M.L. Elam, Z. Ezzat Zadeh, S.Hooshmand and B.H. Arjmandi. Florida State Univ.A18 II 581.18 Comparative study of dried fruits andtheir ability to restore bone microarchitecture in osteopenicC57BL/6 mice. B.J. Smith, K. Hembree, E. Rendina, Y.Wang, D. Marlow, S.L. Clarke, B.P. Halloran and E.A. Lucas.Oklahoma State Univ. and VA Med. Ctr., UCSD.582. DIETARY BIOACTIVE COMPONENTS II:MECHANISMS OF ACTION AND MOLECULARTARGETS IPoster(Sponsored by: Dietary Bioactive Components RIS)SUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-1:45 PM (I); 1:45 PM-2:45 PM (II)A19 I 582.1 Mechanism of Keap1 cysteinesmutated in cancer. R. Calderon, A.L. Eg gler and A.D.Mesecar. Univ. of Illinois at Chicago Col. of Pharm. and PurdueUniv.A20 II 582.2 Capsaicin: a novel therapy for humansmall cell lung cancer. A.M. Dom, J.K. Lau, K.C. Brown, B.S.Shiflett, T.R. Witte, W.E. Hardman and P. Dasgupta. Joan C.Edwards Sch. of Med., Marshall Univ.A21 I 582.3 Allyl isothiocyanate infl uences in vitroinvasion, adhesion and gene expression in SK-Hep1 cells E-S.Hwang. Jeonju Univ., South Korea.A22 II 582.4 Resveratrol modulates MED28(Magicin) expression and inhibits migration in MDA-MB-231human breast cancer cells. M-F. Lee, M-H. Pan, Y-S. Chiou, H.Huang and W.-H. Hong. Chang Jung Christian Univ. and Natl.Kaohsiung Marine Univ., Taiwan.A23 I 582.5 Quercetin induces cell apoptosis viaactivation of AMP-activated protein kinase and inhibition ofprotein elongation in leukemia Jurkat cells. J. Han, Y. Jiang,L. Tang, E. Ortiz, D. Medeiros and D. Lin. Kansas State Univ.and Da Lian Univ., People’s Republic of China.A24 II 582.6 Polyphenolics from pomegranateprevent infl ammation in breast cancer cells in vitro and in vivoand target miRNA 155. N. Banerjee and S.M. Talcott. TexasA&M Univ.A25 I 582.7 Resveratrol inhibits 3T3-L1 adipogenesisthrough direct regulation of insulin receptor. J.Y. Kwon,S.G. Seo, K.W. Lee, S. Yue, J-X. Cheng and K-H. Kim. WeldonSch. of Biomed. Engin., Purdue Univ. and Seoul Natl. Univ.A26 II 582.8 Reduced weight gain and adiposity inC57BL/6 mice provided anthocyanin-rich purple corn extract isdependent on the composition of the high fat diet. M. Lefevre,N. Hergert and A. Zuberi. Utah State Univ. and PenningtonBiomed. Res. Ctr., Baton Rouge.A27 I 582.9 Nutrigenomic effects of hesperidin,the major polyphenol of orange, related to its cardiovascularprotective effects C. Morand, D. Milenkovic, A. Chanet, C.Deval and A. Mazur. INRA, St Genes Champanelle, France.A28 II 582.<strong>10</strong> Effects of pine nuts oil supplementationon serum cholesterol concentration. J. Baek, T.W. Kim, J. Kim,T.H. Kim and M. Choe. Kangwon Natl. Univ., South Korea.A29 I 582.11 Dietary phytosterol esters must behydrolyzed for optimal reduction in cholesterol absorption. T.J.Carden, A.W. Brown, M. Mielke, J. Hang, P.H. Dussault, B.H.Lee, V.L. Schlegel and T.P. Carr. Univ. of Nebraska-Lincoln.A30 II 582.12 A Mediterranean-stylelow-glycemic-load diet reduces the expression of HMG-CoAreductase in mononuclear cells and correlates with decreasesin insulin and LDL oxidation in women with metabolicsyndrome. J.L. Jones, Y-K. Park, J-Y. Lee, R.H. Lerman andM.L. Fernandez. Univ. of Connecticut and Metagenics Inc., GigHarbor, WA.A31 I 582.13 The effects of isofl avones on serumlipids in C57BL/6J mice. E. Mullen and D. Coyle. NorthernKentucky Univ.A32 II 582.14 Correlation of iNOS, eNOS, PPARγ,TNFα and HNF4α gene expressions in subcutaneous adiposetissue of obese women in response to 12-week calorierestricteddiet with or without exercise E.S. A. Barrera, J.I. A.Avendaño, A.D. López, M.M. Godinez, M.G. López, G.D. I.García, N. Perez-Vielma, E.L. Padilla and A.M. García. Natl.Polytech. Inst. and Salvador Zubirán Natl. Inst. of Med. Sci. andNutr., Mexico City.A33 I 582.15 Gelidium amansii, an edible redseaweed, inhibits adipocyte differentiation and ROS productionin 3T3-L1 cells O-H. Lee and B-Y. Lee. Kangwon Natl. Univ.and CHA Univ., South Korea,.A34 II 582.16 Epigallocatechin-3-gallate increasesthe expression and secretion of adiponectin protein in 3T3-L1adipocytes, but not through the insulin signaling pathway C.Montero, S.C. Frost and S.S. Percival. Univ. of Florida.A35 I 582.17 All-trans-retinoic acid attenuatescell swelling and mitochondrial dysfunction following oxygenglucosedeprivation in glial cells. K.S. Panickar and H.D.Dawson. USDA, Beltsville.583. DIETARY BIOACTIVE COMPONENTS III:CHRONIC DISEASE RISK REDUCTION IPoster(Sponsored by: Dietary Bioactive Components RIS)<strong>SUNDAY</strong>SUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-1:45 PM (I); 1:45 PM-2:45 PM (II)A36 I 583.1 Infl uence of garlic and ginger ondiabetic indicators in STZ-induced diabetic rats. M.J. Al-Houli,M. Thomson, K. Al-Qattan, D. J. S. and M. Ali. Kuwait Univ.A37 II 583.2 A fl axseed diet high in SDGameliorates the diabetic phenotype in the male Zucker diabeticrat. W.J. Banz, J.E. Davis, J.L. Cheatwood, M.J. Iqbal andR.W. Clough. Southern Illinois Univ.160
<strong>SUNDAY</strong>A38 I 583.3 High-fat diet with grape seed extractand delta-tocotrienol ameliorate hepatic histopathologicalchanges in a murine model for nonalcoholic steatohepatitis.S.S. Sodhani, D. Dutta, O. Kelly, S. Juma, P. Vijayagopal, N.Mills and V. Imrhan. Texas Woman’s Univ.A39 II 583.4 Preventive effects of betainesupplementation on the development of non-alcoholic fatty liverin rats. C.W. Ahn, D.Y. Kwon and Y.C. Kim. Col. of Pharm.,Seoul Natl. Univ.A40 I 583.5 Effect of dietary portfolio onbiochemical abnormalities of metabolic syndrome. M. Guevara-Cruz, A.R. Tovar, I. Medina-Vera, L. Gil-Zenteno, P. Lopez-Romero, I. Hernandez-Viveros and N. Torres. Natl. Inst. ofMed. Sci. and Nutr. Salvador Zubirán, Mexico City.A41 II 583.6 Effects of sorghum (Sorghumbicolor) extract on glucose and lipid metabolism in high-fat fedC57BL/6N mice. Y. Park and J.H. Park. Hanyang Univ., SouthKorea.A42 I 583.7 Effect of blueberry polyphenols on3T3-F442A preadipocyte differentiation. S. Moghe, S. Jumaand P. Vijayagopal. Texas Woman’s Univ.A43 II 583.8 The dose-dependent effects ofblackberries and their anthocyanins in preventing morbiditiesrelated to diet-induced obesity in ovariectomized rats. W.Gilbert, J.A. Teeple, L. Kaume, S. Graves, L. Howard and L.Devareddy. Univ. of Arkansas.A44 I 583.9 Dietary sterculic oil improves themetabolic state of obese, leptin defi cient ob/ob mice R.T.Pickering, L. Ortinau, K. Nickelson, K. Stromsdorfer, C. Naik,J. Browning, D.E. Bauman, K. Fritsche and J.W. Perfield II.Univ. of Missouri-Columbia and Cornell Univ.A45 II 583.<strong>10</strong> Time course effect of cruciferousand apiaceous vegetable intake on rat CYP1A1 and CYP1A2.N. Strapazzon, C.M. Gallaher, J.K. Kim, W. Thomas, D.D.Gallaher and S. Peterson. Univ. of Minnesota, St. Paul andSch. of Publ. Hlth., Univ. of Minnesota, Minneapolis.A46 I 583.11 In utero exposure to methyl diet andepigenetic modifi cation of breast cancer risk in offspring. S.Bae, K. Cho, L. Mabasa, D.M. Walsh and C.S. Park. NorthDakota State Univ.A47 II 583.12 Effect of calcium and conjugatedlinoleic acid co-supplementation on morphometriccharacteristics of mouse femur. Y. Park, A.G. Scrimgeour, L.J.Marchitelli and Y. Park. Univ. of Massachusetts aAmherst ndU.S. Army Res. Inst. of Envrn. Med., Natick, MA.A48 I 583.13 Consumption of various beans andbone metabolism in ovariectomized rats. Y. Park and S-H. Lee.Hanyang Univ., South Korea.A49 II 583.14 Protein profi le in low-glycinin soymilkdoes not alter bone density or intestinal microbiota in overweightmen. D. Fernandez, N.A. Bringe, J. Lotton, J. Hoeflinger, M.J.Miller and E. Gonzalez de Mejia. Univ. of Illinois, Urbana.A50 I 583.15 Naturally occurring regulators formetal-induced amyloid aggregation and neurotoxicity. J-S.Choi and M.H. Lim. Univ. of Michigan.A51 II 583.16 Fermented Korean red ginsenginhibits the development of oxazolone-induced atopic dermatitisconditions in hairless mice. M-J. Kim, G-E. Ji and M-K. Sung.Sookmyung Women’s Univ., Seoul Natl. Univ. and Bifi do Inc.,Kangwondo, South Korea.584. DIETARY BIOACTIVE COMPONENTS V:MEDICINAL AND FUNCTIONAL FOODSNUTRITIONPoster(Sponsored by: Dietary Bioactive Components RIS)SUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-1:45 PM (I); 1:45 PM-2:45 PM (II)A52 I 584.1 Fiber intervention lowers BUN andserum creatinine in chronic kidney disease patients. Y.A.Salmean, M.S. Segal, B. Langkamp-Henken, M. Canales,G.A. Zello and W.J. Dahl. Univ. of Florida and Univ. ofSaskatchewan Col. of Pharm. and Nutr.A53 II 584.2 Effects of herbal tea or extract onuric acid parameters in humans and rats. X. Yang, M. Rott, A.Cooper and M. Maher. Univ. of Wisconsin-La Crosse.A54 I 584.3 Effect of calcium supplementationcombined with fucoidan and chitooligosaccharide on cecalshort-chain fatty acid formation and calcium absorption inovariectomized rats. M-H. Kim, S. Yun, C. Lee and J. Surh.Kangwon Natl. Univ., South Korea.A55 II 584.4 Effects of fucoidan supplementationon antioxidant capacities in ovariectomized rats. M-H. Kimand M-H. Kang. Kangwon Natl. Univ. and Hoseo Univ., SouthKorea.A56 I 584.5 Comparative nutrition composition ofripe versus unripe California pomegranate fruit. R. Wildman,R.S. Bruno and T. Jalili. Texas State Univ., Sam Marcos, Univ.of Connecticut and Univ. of Utah.A57 II 584.6 Development of function foods usingpsyllium husk and wheat bran fractions: phytic acid contents.J. Sidhu, M. Bhatti, S. Al-Hooti, J. Al-Saqer, H. Al-Amiri andE. Al-Salem. Kuwait Univ., Kuwait Inst. for Sci. Res. and KuwaitFlour Mills, Kuwait City.A58 I 584.7 Health functional effect of raspberrybamboo salt. K-Y. Park, X. Zhao, J. Song, J-H. Lee and S-Y.Kim. Pusan Natl. Univ. and Rural Develop. Admin, Suwon,South Korea.A59 II 584.8 Anti-obesity and anti-infl ammatoryeffects of cheonggukjang. K-Y. Park, J-Y. Kim and S-H. Moon.Pusan Natl. Univ. and Kyungnam Col. of Info. and Technol.,South Korea,.A60 I 584.9 Mango modulates body compositionof ovariectomized mice and mice fed high fat diet. E. Vitale, S.Peterson, W. Li, Y. Wang, S. Clarke, B. Smith and E.A. Lucas.Oklahoma State Univ.A61 II 584.<strong>10</strong> Sorghum extract lowers the lymphaticabsorption of cholesterol in rats. J. Kim, Y. Lee, M.C. Seo, K.S.Woo and S.K. Noh. Changwon Natl. Univ., South Korea andRural Develop. Admin., Miryang, South Korea.A62 I 584.11 Feeding resistant starch to Goto-Kakizaki diabetic rats improves pancreatic beta cell mass ofdams and fasting glucose of offspring. L. Shen, M.J. Keenan,A.M. Raggio, J. Zhou, C.C. Williams and R.J. Martin. LSUAgCtr. and VA Med. Ctr.A63 II 584.12 Effects of short-term and long-termconsumption of soy germ and/or tomato powder on expressionand activity of hepatic phase I and phase II enzymes in rats.K.E. Zuniga and J.W. Erdman, Jr. Univ. of Illinois at Urbana-Champaign.SUN161
NUTRITIONA64 I 584.13 Enzyme activities and physiologicalfunctionalities of lactic acid bacteria isolated from Korean meju(fermented soybean block). K-Y. Park, J-K. Jeong, Y. Zheng,S-H. Kim, H-S. Choi and G-J. Han. Pusan Natl. Univ., DongjuCol. Sch. of Culinary Art and Baking Technol. and NIAST, RDA,Suwon, South Korea.A65 II 584.14 Lactobacillus GG treatmentameliorates alcohol-induced intestinal epithelial cell dysfunction.Y. Wang, Y. Liu, I. Kirpich, C. McClain and W. Feng. Univ. ofLouisville.A66 I 584.15 Persistence of Lactobacillus reuteriDSM17938 in the human intestinal tract in response to differentstorage conditions. T.J. Smith, D.J. Anderson, A. Sikes, L.M.Margolis and A.J. Young. U.S. Army Res. Inst. of Envrn. Med.,Natick, MA and Natick Soldier Res., Develop. and Engin. Ctr.A67 II 584.16 Safety of novel Bifi dobacterium strainsdemonstrated in a human infant surrogate, the neonatal pig.T.M. Herfel, S. Jacobi, X. Lin, C. Walker, M. Russell, C. Stahland J. Odle. North Carolina State Univ. and Mead JohnsonNutritionals, Evansville, IN.A68 I 584.17 Secreted bioactive factors fromBifi dobacterium longum increase the levels of intestinal fastinginducedadipocyte factor in vitro. R. Cotten, P. Pham, S. Parker,D. Vattem, B.J. Friedman and V. Maitin. Texas State Univ.,San Marcos.A69 II 584.18 Effect of human milk oligosaccharideson rotavirus infectivity in MA<strong>10</strong>4 cells. X. Chen, M. Li, T.B.Kuhlenschmidt, M.S. Kuhlenschmidt and S.M. Donovan.Univ. of Illinois, Urbana.A70 I 584.19 Expression and secretion of IL-8by intestinal HT-29 cells after incubation with supernatantsof viable and heat-inactivated Escherichia coli. S. Kuntz, M.Schild, S. Rudloff and C. Kunz. Justus Liebig Univ. Giessen,Germany.A71 II 584.20 Effect of dietary synbiotics onweightlessness-induced bone loss. C. Blanton and A.Gabaldon. Idaho State Univ. and Colorado State Univ.,Pueblo.585. LIPID AND FATTY ACID METABOLISM ANDTRANSPORTPoster(Sponsored by: Energy and Macronutrient MetabolismRIS)SUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-1:45 PM (I); 1:45 PM-2:45 PM (II)A72 I 585.1 The diacylglycerol kinase inhibitorR59022 attenuates trans-<strong>10</strong>, cis-12 conjugated linoleic acidmediatedinfl ammatory signaling and insulin resistance inprimary human adipocytes K.B. Martinez, S. Shyamasundar,C.C. Chuang, A. Overman, A. Kennedy and M. McIntosh.Univ. of North Carolina at Greensboro and Vanderbilt Univ.A73 II 585.2 The phospholipase C inhibitor U73122inhibits trans-<strong>10</strong>, cis-12 conjugated linoleic acid-mediatedinfl ammatory signaling and insulin resistance in humanadipocytes W. Shen, K. Martinez, C.C. Chuang, A. Overmanand M. Mcintosh. Univ. of North Carolina at Greensboro.A74 I 585.3 Serum and liver lipids in rats fed 20%fat diets containing corn oil or cottonseed oil. J. Radcliffe.Texas Woman’s Univ.-Houston Ctr.A75 II 585.4 Reduced docosahexaenoic acidmetabolism and concentration in brain phospholipids ofcalcium-independent phospholipase A2 VIA (iPLA2β-knockoutmice. Y. Cheon, H-W. Kim, M. Igarashi, H.R. Modi, L. Chang,K. Ma, D. Greenstein, M. Wohltmann, J. Turk, S.I. Rapoportand A. Taha. NIA and NIMH, NIH and Washington Univ. Sch. ofMed.A76 I 585.5 Acyl-CoA synthetase-1 is necessaryfor high fat diet-induced triacylglycerol accumulation in theheart. T.J. Grevengoed, J.M. Ellis and R.A. Coleman. Univ. ofNorth Carolina at Chapel Hill.A77 II 585.6 Effects of 9-cis-retinoic acid onfatty acid oxidation induced by clofi brate in primary culturedheptocytes from newborn pigs. Y. Liu, L. Xi, T.M. Herfel, S.K.Jacobi and J. Odle. North Carolina State Univ.A78 I 585.7 Hydrolysis of phytosterol esters in theintestine is required for their cholesterol-lowering effects. A.W.Brown, T.J. Carden, J. Hang, P.H. Dussault and T.P. Carr.Univ. of Nebraska-Lincoln.A79 II 585.8 The role of SREBP-1 in lipogenesisin bovine mammary epithelial cells. L. Ma and B. Corl. VirginiaTech.A80 I 585.9 1, 25-Dihydroxyvitamin D3 modulateslipid metabolism in 3T3-L1 and HepG2 cell lines P. B.T. Pichiahand Y-S. Cha. Chonbuk Natl. Univ., South Korea.A81 II 585.<strong>10</strong> Incorporation of essential and nonessentialfatty acids into distinct lipid classes in cultured bovineand porcine liver and small intestine explants. C. Caldari-Torres, A.J. Lengi, D.M. Shepherd, J.A. Stamey and B.A.Corl. VPI and State Univ. and Ohio State Univ.A82 I 585.11 ABCD2 is abundant in adipose tissueand opposes disruptions in lipid metabolism by dietary erucicacid (C22:1). J. Liu, S. Liang, X. Li, A. Pujol and G. Graf.Univ. of Kentucky and Molec. Genet. and Inst. of Neuropathol.,Barcelona.A83 II 585.12 Dietary fatty acid compositioninfl uences levels of fatty acid ethanolamides but not energeticsin Syrian golden hamsters. L. Lin, T.C. Rideout, S.V. Harding,H. Yang and P.J. H. Jones. Univ. of Manitoba.A84 I 585.13 Single nucleotide polymorphismsaffecting phosphatidylcholine transport are associated withobesity. K.D. Corbin, K-A. da Costa, W. Sha, M.F. Abdelmalek,A.M. Diehl and S.H. Zeisel. Univ. of North Carolina at ChapelHill, Kannapolis, Univ. of North Carolina at Charlotte and DukeUniv. Med. Ctr.A85 II 585.14 The obese intestine: mucosaltriacylglycerol accumulation in mouse models of obesity. N.Malik, S. Chon, A. Choi, Y.X. Zhou and J. Storch. RutgersUniv.586. DIETARY FACTORS AFFECTING LIPIDMETABOLISM<strong>SUNDAY</strong>Poster(Sponsored by: Energy and Macronutrient MetabolismRIS)SUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-1:45 PM (I); 1:45 PM-2:45 PM (II)A86 I 586.1 Effects of high-fat dietary intakeon lipid profi les in rat brain and liver. S. Zhang, L. Austin, E.Vazquez and M. Puchowicz. Case Western Reserve Univ.162
<strong>SUNDAY</strong>A87 II 586.2 Unrefi ned and refi ned black raspberryseed oils signifi cantly lower triglycerides and moderately affectcholesterol metabolism in male Syrian hamsters. M.M. Ash,K.A. Wolford, T.J. Carden, K.T. Hwang and T.P. Carr. Univ. ofNebraska-Lincoln and Seoul Natl. Univ.A88 I 586.3 Marginal vitamin B6 defi ciency affectsfatty acid profi les in healthy men and women. M. Zhao, Y.Lamers, M.A. Ralat, B.S. Coats, P.W. Stacpoole, Y-Y. Chi,K.E. Muller, J.R. Bain, C.B. Newgard and J.F. Gregory III.Univ. of Florida and Duke Univ. Med. Ctr.A89 II 586.4 The role of gut microbiota in the lowdensitylipoprotein cholesterol-lowering effects of plant sterolesters. M.C. Dubenetzky, H. Rasmussen, T.P. Carr and J.Walter. Rush Univ. Med. Ctr. and Univ. of Nebraska-Lincoln.A90 I 586.5 Effect of high docosahexaenoic acidalgaloil on body fat and serum lipids in mice. A.G. Shelton, R.Pietrofesa and K.M. Barnes. West Virginia Univ.A91 II 586.6 Effects of different trans-fatty acids onlipid and lipoprotein metabolism in male F1B hamsters. J. Kraftand A.L. Lock. Univ. of Vermont and Michigan State Univ.A92 I 586.7 In vitro assessment of thephytochemicals resveratrol, quercetin, mangiferin andepigallocatechin gallate on lipid accumulation in the 3T3-L1 cellline M-W. Taing, P.N. Shaw, S. Roberts-Thomson, M. Gidley,R. Dietzgen and G. Monteith. Univ. of Queensland and Dept.of Employment, Econ. Develop. and Innovation, QueenslandGovt., Brisbane.A93 II 586.8 Effect of a sphingolipid-enriched dieton serum lipid profi le and cholesterol metabolism in humans.R. Vanu Ramkumar, P.J. H. Jones, D.D. Buckley and J.E.Heubi. Univ. of Manitoba and Children’s Hosp. Med. Ctr., Univ.of Cincinnati.A94 I 586.9 High HDL improves the response toa Mediterranean style low glycemic load diet in women withmetabolic syndrome. J. Barona, J.J. Jones, M. McIntosh, W.Najm, R.H. Lerman and M.L. Fernandez. Univ. of Connecticutand Univ. of Florida, Jacksonville, Univ. of California, Irvine andMetagenics Inc., Gig Harbor, WA.587. CARBOHYDRATE DIGESTION: ENERGYBOUNDARY BETWEEN PLANT AND ANIMALKINGDOMSPoster(Sponsored by: Energy and Macronutrient MetabolismRIS)SUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-1:45 PM (I); 1:45 PM-2:45 PM (II)A95 I 587.1 Adding resistant starch in breakfastdrink on glycemia and satiety in humans. C.G. Weber, J. Louk,A. Schrage, B. Craemer, J. Lattimer and M. Haub. KansasState Univ.A96 II 587.2 Assessing the long-term effects ofdietary starch, glucose and fructose in pigs: effects on glucosetolerance and growth. P.M. Cline, C.R. Dove, T. Tsai and M.J.Azain. Univ. of Georgia.A97 I 587.3 Polydextrose and soluble corn fi bersignifi cantly increase stool weight, but do not infl uence wholegut transit time in healthy adults D. Timm, W. Thomas, L.Sanders, T. Boileau and J.L. Slavin. Univ. of Minnesota, St.Paul and Minneapolis, Tate & Lyle Hlth. & Nutr. Sci., Decaturand General Mills, Minneapolis.A98 II 587.4 Glycemic and insulin response toraisins, grapes and bananas in college aged students. J.A.Anderson, H.A. Huth, M.M. Larson, A.J. Colby, E.J. Krieg,L.P. Golbach, K.A. Simon, S.L. Wasmundt, C.J. Malone andT. Wilson. Winona State Univ., MN.A99 I 587.5 Glycemic response of type 2 diabeticsto raisins. J.A. Anderson, K.F. Andersen, R.A. Heimerman,M.M. Larson, S.E. Baker, M.R. Freeman, A. Carughi and T.Wilson. Winona State Univ., MN and Sun-Maid Growers ofCalifornia, Kingburg.A<strong>10</strong>0 II 587.6 Validation of insulin sensitivity andsecretion indices derived from the liquid meal tolerance test.K.C. Maki, K.M. Kelley, A.L. Lawless, R.L. Hubacher andT.M. Rains. Provident Clin. Res., Glen Ellyn, IL.A<strong>10</strong>1 I 587.7 Reliability characteristics ofcontinuous glucose monitoring in overweight and obese menand women with type 2 diabetes mellitus. K.C. Maki, K.H.Rubin, N.V. Matusheski, M.R. Rubin, M.S. Reeves, A.L.Lawless, V.N. Kaden and R.M. Black. Provident Clin. Res.,Glen Ellyn, IL and Kraft Foods Inc.A<strong>10</strong>2 II 587.8 A double-blind, randomized, controlledcrossover trial to assess the prebiotic effects of arabinoxylanoligosaccharidesin healthy men and women K.C. Maki,G. Gibson, R. Dickman, C.W. C. Kendall, C-Y.O. Chen, N.Almeida and J. Blumberg. Provident Clin. Res., Glen Ellyn,IL, Univ. of Reading, U.K., Kellogg Co., Univ. of Toronto andTufts Univ.A<strong>10</strong>3 I 587.9 Effects of type 2 resistant starchconsumption on insulin sensitivity in men and women. K.C.Maki, C.L. Pelkman, K.M. Kelley, A.L. Lawless, A. Schildand T.M. Rains. Provident Clin. Res., Glen Ellyn, IL and Natl.Starch LLC, Bridgewater, NJ.A<strong>10</strong>4 II 587.<strong>10</strong> D-Lactate disturbed mitochondrialenergy production in rat brain and heart but not liver. B.Ling, F. Peng, J. Alcorn, B. Bandy and G. Zello. Univ. ofSaskatchewan.A<strong>10</strong>5 I 587.11 Effects of Gatorade® on performanceof moderately strenuous aerobic exercise lasting under anhour. R.A. DiSilvestro, E. Joseph, T. Marshall, S. Hart andC.B. Swain. Ohio State Univ.588. REGULATION OF FOOD INTAKENUTRITIONPoster(Sponsored by: Energy and Macronutrient MetabolismRIS)SUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-1:45 PM (I); 1:45 PM-2:45 PM (II)A<strong>10</strong>6 I 588.1 Rapid onset of peripheral and centralleptin resistance in rats offered chow, lard, and 30% sucrosesolution J.W. Apolzan and R.B. S. Harris. Med. Col. ofGeorgia.SUN163
NUTRITIONA<strong>10</strong>7 II 588.2 A pilot study of eating behaviors inwomen with and without self-reported eating disorders, asassessed by a universal eating monitor S. Choi. Univ. of RhodeIsland.A<strong>10</strong>8 I 588.3 Long-term effects of a health-atevery-sizeintervention on eating patterns in premenopausaloverweight women. V. Leblanc, V. Provencher, C. Bégin, L.Corneau, A. Tremblay and S. Lemieux. Laval Univ.A<strong>10</strong>9 II 588.4 Using puréed vegetables to reduceenergy intake and increase vegetable intake in adults. A.D.Blatt, L.S. Roe and B.J. Rolls. Penn State.A1<strong>10</strong> I 588.5 Effect of sugars-containing beverageson satiety and short-term food intake in normal weight andoverweight/obese boys. N. Bellissimo, K.L. Poirier, L.J.Bennett and N. Lynch. Mount Saint Vincent Univ., Canada.A111 II 588.6 The satiating effect of egg is higherthan fresh cheese when given as isocaloric solid preloads inhumans. A. Marsset-Baglieri, A. Diouani, G. Fromentin, G.Airinei, R. Benamouzig, F. Nau, D. Tomé and C. Gaudichon.AgroParisTech-INRA, CRNH Ile de France, Bobigny andAgrocampus-INRA, Rennes.A112 I 588.7 High-tailing it to fast food restaurants:how analysis of fast food consumption may be skewed by thoseat both extremes of the BMI distribution. B. Wansink, D.R. Justand R.W. Patterson. Cornell Univ.A113 II 588.8 Pulses as a functional food to controlsatiation, satiety, food intake and glycaemia B.L. Luhovyy,R.C. Mollard, C.E. Smith, M.F. Nunez, Y. Liu, A. Zykus andG.H. Anderson. Univ. of Toronto.A114 I 588.9 Effects of food form on subjective andphysiological markers of appetite. Y. Zhu and J. Hollis. IowaState Univ.A115 II 588.<strong>10</strong> Effects of food-deprivation on calorieestimation. A. Tal, M. Shimizu and B.C. Wansink. CornellUniv.A116 I 588.11 Effect of fi bre-lipid-protein mixtures onsatiety in mice. R. Rasoamanana, C. Chaumontet, D. Tomé,G. Fromentin and N. Darcel. AgroParisTech.A117 II 588.12 The effect of fi ber ingredients onsatiety and food intake: a systematic review. M.J. Diedrick,K. Greaves and J.L. Slavin. Univ. of Minnesota, St. Paul andKellogg Co.A118 I 588.13 Bitter compounds decrease gastricemptying and infl uence intestinal nutrient transport. V. Mani,N.K. Gabler and J. Hollis. Iowa State Univ.A119 II 588.14 Fiber and gut hormones: inconsistenteffect or imperfect research? A. Klosterbuer, H.J. Willis, K.Greaves and J.L. Slavin. Univ. of Minnesota, St. Paul andKellogg Co.A120 I 588.15 Addition of fi ber to a meal does notconsistently alter gut hormone levels in humans. A. Klosterbuer,L.M. Sanders, W. Thomas and J.L. Slavin. Univ. of Minnesota,St. Paul, Tate & Lyle Hlth. and Nutr. Sci., Decatur and Univ. ofMinnesota, Minneapolis.A121 II 588.16 The role of post-ingestive cues infeeding preferences by mice that lack taste capabilities. J.M.Stratford and T.E. Finger. Univ. of Colorado Denver AnschutzMed. Campus.A122 I 588.17 Sex differences in the acute effect ofan estrogen metabolite on binge eating in rats. R.K. Babbs,F.H. Wojnicki and R.L. Corwin. Penn State.A123 II 588.18 Portable breakfast foods, breakfastconsumption, and protein intakes among collegiate breakfastskippers C. Lahr, T. Reichert, D. Memmer and L. Lowery.Sodexo, Holy Spirit Hosp., Camp Hill, PA, Univ. of Akron andWinona State Univ., MN.A124 I 588.19 A daily popcorn snack improvesdietary quality. V. Nguyen, D. Kawiecki, S. Pardo, L. Cooper,A. Kuchnia, T. Papadopoulos, J. Lowndes and J. Rippe.Rippe Lifestyle Inst., Celebration, FL.589. BREASTFEEDING: DETERMINANTS AND THEEFFECTS ON HEALTH OUTCOMESPoster(Sponsored by: Lactation RIS)<strong>SUNDAY</strong>SUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-1:45 PM (I); 1:45 PM-2:45 PM (II)A125 I 589.1 Nutritive and non-nutritive suck,swallow, breathe coordination during breastfeeding P.Hartmann, H. McClellan, T. Williams, J. Kent, A. Hepworth,C. Garbin and D. Geddes. Univ. of Western Australia.A126 II 589.2 Supplementation of human milkwith calcium, phosphorus, and post-discharge formula A.D.Fogleman, P. Sakamoto, R.S. Cohen and J.C. Allen. NorthCarolina State Univ., Mothers’ Milk Bank, San Jose andStanford Univ. Sch. of Med.A127 I 589.3 Growth and safety of preterm infantsfed a new liquid human milk fortifi er. C.L. Berseth, S.H.Mitmesser, S. Stolz, C. Harris, F. Moya and P. Sisk. MeadJohnson Nutr., South East Area Hlth. Educ. Ctr., Wilmington,NC and Forsyth Med. Ctr., Winston-Salem.A128 II 589.4 Adherence to a Mediterranean-stylediet and change in infl ammatory biomarkers and fatty acidprofi les in lactating women. N. Stendell-Hollis, P. Thompson,J. Winzerling, M. Daines and C. Thomson. Univ. of Arizona,Arizona Cancer Ctr. and Univ. Med. Ctr., Tucson.A129 I 589.5 Vitamin D status in breastfeedingwomen in Oklahoma. L. Park, T. Kennedy, S. Grant, N.Aubuchon-Endsley, D. Traore, B.J. Stoecker and D. Thomas.Oklahoma State Univ.A130 II 589.6 The relation of parenting stress onwhite blood cells and lymphocytes in breastfeeding women. T.Henard, T. Kennedy, J. Byrd-Craven, N. Aubuchon-Endsley,S. Grant, D. Traore, L. Hubbs-Tait and D. Thomas. OklahomaState Univ.A131 I 589.7 Relations between diets ofbreastfeeding women and stress. M.D. Gilchrist, T. Kennedy,N. Aubuchon-Endsley, C. Sterling, E. Senossi and D.Thomas. Oklahoma State Univ.A132 II 589.8 Diet quality is higher amongoverweight and obese women who breastfeed as comparedto those who formula feed. G.A. Moening, C.A. Lovelady, D.West, R. Brouwer, K. Krause and T. Ostbye. Univ. of NorthCarolina at Greensboro and Duke Univ.A133 I 589.9 Effect of low dose estrogen/progesterone versus progesterone-only oral contraceptiveson lactation-induced bone loss. K.D. Little and D. Schubeck.Cleveland State Univ. and MetroHlth. Med. Ctr.A134 II 589.<strong>10</strong> Voices of women of lowSES:overcoming breastfeeding barriers. L.M. Raburn, J.J. Helveyand K.F. Kavanagh. Univ. of Tennessee, Knoxville.164
<strong>SUNDAY</strong>A135 I 589.11 Early termination of breastfeeding. H.Schwager, T. Kennedy, N. Aubuchon-Endsley, D. Thomas, T.Valtr and A. Aston. Oklahoma State Univ.A136 II 589.12 Larger infant size at birth reduces thenegative association between prepregnancy body mass indexand the duration of breastfeeding. K.M. Rasmussen and S.A.Leonard. Cornell Univ.A137 I 589.13 Dietetic interns and internshipdirectors have positive attitudes toward breastfeeding andinterns intend to support and promote breastfeeding in theirfuture practice. C.L. Mitchell, R.S. Pobocik, N.S. Boudreauand Y. Kim. Sch. of Family and Consumer Sci., Bowling GreenState Univ.A138 II 589.14 The implication of training inbreastfeeding peer counselor support. E.M. Sullivan, W.E.Bignell, A. Andrianos and A.K. Anderson. Univ. of Georgiaand Intl. Board of Lactation Consult. Examiners, Falls Church,VA.A139 I 589.15 Breastfeeding knowledge and beliefsamong undergraduate students in the southeastern UnitedStates: what is baseline? Z. Lou, J.C. Nicklas, M. Habibi, L.T.Murphy and K.F. Kavanagh. Univ. of Tennessee, Knoxville.590. HUMAN MILK BIOLOGYPoster(Sponsored by: Lactation RIS)SUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-1:45 PM (I); 1:45 PM-2:45 PM (II)A140 I 590.1 Randomized controlled trial ofdocosahexaenoic acid in women to improve donor milk. C.J.Valentine, G. Morrow, A.E. Hodge, M. Augustine, M. Pennel,A. Haban-Bartz, K. Collins and L.K. Rogers. NationwideChildren’s Hosp. and Ohio State Univ.A141 II 590.2 The production and composition ofmilk from <strong>10</strong>–60 days of lactation in mothers who deliveredprematurely in Western Australia. P. Hartmann and C.T. Lai.Univ. of Western Australia.A142 I 590.3 Free amino acid content in breastmilk in adolescent and adult nursing mothers. N.J. Flores, E.Villegas, D. Villacis, M. Fornassini, A.M. San Gabriel andM. Baldeon. San Francisco de Quito Univ., Ecuador and Publ.Relations Sci. Affairs, Ajinomoto, Japan.A143 II 590.4 Longitudinal changes in lactoferrinconcentrations in human and bovine milk – a global systematicreview. D. Rai, W. Zhuang and A. Adelman. Mead JohnsonNutr., Evansville, IN.A144 I 590.5 The apparent role of ATP7A inplacenta and mammary epithelial cells before and after birth,as determined in transgenic mice overexpressing the humantransporter J. Wadwa, N. Nguyen, H. Fullriede, G. Brennan, T.Henson, A. Figueroa, R. Llanos, J.F. B. Mercer, D. Freestone,A. Michalczyk, L. Ackland and M.C. Linder. California StateUniv., Fullerton and Deakin Univ., Australia.A145 II 590.6 Mammary infl ammation and hypoxiaduring lactogenesis in the obese viable yellow agouti (Avy)mouse. D.L. Hadsell, J. Tong and W. Olea. Baylor Col. ofMed.A146 I 590.7 Milk fat globule mRNA elucidatesmammary gland gene expression during initiation of lactationin humans. M.A. Mohammad, P. Sen, D.L. Hadsell, A.L.Sunehag and M.W. Haymond. Baylor Col. of Med.591. SOCIOCULTURAL AND DIETARYDETERMINANTS OF OBESITY IN LOW ANDMIDDLE INCOME COUNTIESPoster(Sponsored by: International Nutrition Council)NUTRITIONSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-1:45 PM (I); 1:45 PM-2:45 PM (II)A147 I 591.1 Number and type of meals consumedon weekdays and weekend days by normal weight andoverweight Puerto Rican children at three different schoollevels. A.M. Preston, H. Venegas, R.M. Velez-Rodriguez andC.A. Rodriguez. Univ Puerto Rico-Med Sci. and Univ PuertoRico Sch of Publ. Hlth.A148 II 591.2 Socioeconomic profi le of obeseschool children from Guadalajara, Mexico E.M. Vasquez-Garibay, J.L. Gonzalez-Rico, C. Cabrera-Pivaral and G.J.González-Pérez. Univ. of Guadalajara and Specialty Hosp.,Mexican Inst. of Social Security, Guadalajara.A149 I 591.3 Associated factors to family dysfunctionin obese and nonobese school children. E.M. Vasquez-Garibay,J.L. Gonzalez-Rico, C. Cabrera-Pivaral, G. González-Pérezand R. Troyo-Sanroman. Univ. of Guadalajara and SpecialtyHosp., Mexican Inst. of Social Security, Guadalajara.A150 II 591.4 Differences in the score of areasof family dynamic between obese versus nonobese schoolchildren. E.M. Vasquez-Garibay, J.L. Gonzalez-Rico, C.Cabrera-Pivaral, G. González-Pérez and R. Troyo-Sanroman.Univ. of Guadalajara and Specialty Hosp., Guadalara.A151 I 591.5 Overweight, obesity, diet and physicalactivity in the United Arab Emirates S.W. Ng, S. Zaghloul, H.I.Ali, G. Harrison, K. Yeatts, M. El-Sadig and B.M. Popkin. Univ.of North Carolina at Chapel Hill, Kuwait Inst. for Sci. Res., Univ.of Hawaii at Manoa, United Arab Emirates Univ. and UCLA.A152 II 591.6 Use of population-specifi c body massindex and waist circumference cut points across countries.Y. Wang, H. Lim, X. Chen and T.T. Nguyen. Johns HopkinsBloomberg Sch. of Publ. Hlth.A153 I 591.7 Transitioning out of the nutritiontransition: using a socio-political lens for understanding dietarychanges in the developing world. E.C. Monterrosa and C.M.Porter. Univ. of South Carolina, Cornell Univ. and Univ. ofWyoming.A154 II 591.8 Trends in Chinese snacking behaviorand socio-economic role from 1991 to 2009. Z. Wang, F. Zhai,B. Zhang and B.M. Popkin. Univ. of North Carolina at ChapelHill and Natl. Inst. of Nutr. and Food Safety, Beijing.A155 I 591.9 The status and trends of physicalactivity among Chinese adults, 1991 to 2009 B. Zhang, H.Wang, C. Su, J. Zhang, W. Du and F. Zhai. Chinese Ctr. forDis. Control and Prevent., Beijing.A156 II 591.<strong>10</strong> Trend of distribution of body massindex among adults in Liaoning provinces from 1989 to 2006.S-j. Li, X. Li, D-c. Luan, Z-m. Liu and X-w. Jin. Liaoning Ctr.for Dis. Control and Prevent., People’s Republic of China.SUN165
NUTRITIONA157 I 591.11 Trends and patterns of energy intakeamong adults in Shandong Province, 2000–2009 J. Zhang, S.Li and D. Liu. Shandong Ctr. for Dis. Control and Prevent.,People’s Republic of China.A158 II 591.12 Dynamic changes of dietarycomposition among adults in Henan Province, China S. Zhang,X. Zhan, D. Zhang, F. Chao, B. Ye and P. Fu. Henan Ctr. forDis. Control and Prevent., People’s Republic of China.A159 I 591.13 Study on the trends of dietary intakeand body mass index among adults in Hunan Province, China,1991–2009 J-w. Liu, Z-w. Fu and G-c. Li. Hunan Ctr. for Dis.Control and Prevent., People’s Republic of China.A160 II 591.14 Age-specifi c trends in prevalence ofoverweight in China: 1991–2009. L.M. Jaacks, P. Gordon-Larsen, E.J. Mayer-Davis, L.S. Adair and B.M. Popkin. Univ.of North Carolina at Chapel Hill.592. DIETARY AND NUTRITIONAL ASSESSMENTPoster(Sponsored by: International Nutrition Council )SUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-1:45 PM (I); 1:45 PM-2:45 PM (II)A161 I 592.1 Assessing dietary intake in populationsat differing stages of economic development. E. Brown, S.McLemore, R.A. Durazo-Arvizu, L.R. Dugas, N. Steyn andA. Luke. Loyola Univ. Chicago, Maywood and Human Sci. Res.Council, Cape Town.A162 II 592.2 Food choices, body mass index,C-reactive protein and blood lipids in foreign-born AfroCaribbeans and their United States-born counterparts in SouthFlorida E. Davis and F. Huffman. Duplin County Hlth. Dept.,NC and Florida Intl. Univ. Stempel Sch. of Publ. Hlth.A163 I 592.3 What are African women eatingduring pregnancy? S.E. Lee, S. Talegawkar, M. Merialdi andL.E. Caulfield. Johns Hopkins Bloomberg Sch. of Publ. Hlth.and World Hlth. Org., Geneva.A164 II 592.4 Content and bioavailability ofmicronutrients in street foods of low income groups, Nairobi,Kenya M.A. Oyunga, J. Waudo and A. Makokha. Kenya Agr.Res. Inst., Kisumu, Kenyatta Univ. and Jomo Kenyatta Univ. ofAgr. & Technol., Kenya.A165 I 592.5 Knowledge and interest in nutritionand related aspects among fi rst-year Kuwait Universitystudents. F. El-Sabban and H.E. Badr. Col. for Women, KuwaitUniv. and Ministry of Hlth., Kuwait.A166 II 592.6 Analysis of dietary intake patterns ofcomplementary foods in Bangladeshi children 6-23 months ofage and simulated intervention options. H. Pachon, N. Hassan,R. Haider, S. Rasheed, C.S. B. Jalal and T. Sanghvi. CIAT,Cali, Colombia, Univ. of Dhaka, THAN Fndn., ICDDR,B, BRACand AED-ARTS, Dhaka, Bangladesh.A167 I 592.7 “Mommy, what are you eating?”—examining the links between the maternal and child diet in thecontext of the household food environment E.C. Monterrosa,G. Pelto and K.M. Rasmussen. Cornell Univ. and Univ. ofSouth Carolina.<strong>SUNDAY</strong>A168 II 592.8 Cortisol response to a meal challengein 15-22 month old infants in rural Ghana. C.P. Stewart, K.D.Laugero, E.R. York, L.H. Allen, S. Adu-Afarwuah, A. Larteyand K.G. Dewey. Univ. of California, Davis, USDA, Davis andUniv. of Ghana.A169 I 592.9 Increasing dietary diversity reduceslikelihood of growth faltering among infants receiving a lipidbasednutrient supplement in Malawi. B.N. Hopping, L.S.Adair, M.E. Bentley, V.L. Flax, M. Parker, P. Chitsulo, C.S.Chasela, D. Kayira, C.M. van der Horst, D.J. Jamieson, Z.Kacheche, A. Soko, R.J. Knight and B. Tohill. Univ. of NorthCarolina at Chapel Hill, Intl. Food Policy Res. Inst., Washington,DC, UNC Project, Lilongwe, Malawi, Ctrs. for Dis. Control andPrevent. and Principia, Chapel Hill.A170 II 592.<strong>10</strong> Modeling linoleic acid and alphalinolenicacid requirements for infants and young children indeveloping countries. Z. Yang and S.L. Huffman. GlobalAlliance for Improved Nutr., Geneva and Univ. of California,Davis.A171 I 592.11 Household dietary diversity and lowhunger score positively predict child dietary diversity and Ferich food consumption but not feeding frequency in indigenousrural Guatemalan children. J.L. Leroy, D. Olney, S. Richterand M. Ruel. Intl. Food Policy Res. Inst., Washington, DC.A172 II 592.12 The effect of portion size on foodintake of 3 to 6 year old children in Kunming, China L.P. Smith,H. Wen, L. Rui and D. Humphries. Yale Sch. of Publ. Hlth. andKunming Med. Univ., People’s Republic of China.A173 I 592.13 The cultural recipe: Mexican mothers’conceptualizations and complementary feeding practices. E.C.Monterrosa, G. Pelto and K.M. Rasmussen. Cornell Univ.and Univ. of South Carolina.A174 II 592.14 Participation in a nutrition educationprogram is associated with improved caregiver knowledge ofhealthful child feeding practices and improved dietary adequacyamong underweight Ugandan children. S.B. Ickes, S.B. Jilcott,J. Myhre, B. Charles, L.S. Adair, H. Thirumurthy, S. Handa,M.E. Bentley and A. Ammerman. Cornell Univ., East CarolinaUniv. Brody Sch. of Med., World Harvest Mission, Uganda andUniv. of of North Carolina at Chapel Hill.A175 I 592.15 Infant and young child feedingpractices and child undernutrition in Bangladesh: insights fromnationally representative data. A.A. Zongrone, K. Winskelland P. Menon. Cornell Univ., Rollins Sch. of Publ. Hlth., EmoryUniv. and Intl. Food Policy Res. Inst., New Delhi.A176 II 592.16 Maternal prepregnancy BMI is notassociated with breastfeeding duration, dietary diversity, orchild feeding practices in low-income Mexican children 1–24months old E.C. Monterrosa, L. Neufeld, U. Ramakrishnan,K. Egan, E.A. Frongillo and K.M. Rasmussen. CornellUniv., Micronutrient Initiative, Ottawa, Natl. Inst. of Publ. Hlth.,Cuernavaca, Emory Univ. and Univ. of South Carolina.A177 I 592.17 Association of caregiver and childbehaviors during feeding with child acceptance of food inMalawi. B.A. Keane, V.L. Flax, M.E. Bentley, L.S. Adair, J.C.Phuka and P. Ashorn. Univ. of North Carolina at Chapel Hill,Col. of Med., Univ. of Malawi and Univ. of Tampere Med. Sch.,Finland.A178 II 592.18 Unpacking behavior changecommunication pathways to strengthen program evaluationin rural Bangladesh. R. Avula, A.S. Chowdhury, K.S. Saha,M.I. Bhuiyan, C.S. B. Jalal, R. Haque, S. Siraj, E.A. Frongillo,Jr. and P. Menon. Univ. of South Carolina, BRAC, Dhada,Bangladesh and Intl. Food Policy Res. Inst., Washington, DC.166
<strong>SUNDAY</strong>A179 I 592.19 Determining the relationship of infantand young child feeding practices and nutritional status amongchildren 6 to 23 months in Uganda. S.B. Ickes, V. Flax and R.J.Stoltzfus. Cornell Univ. and Univ. of North Carolina at ChapelHill.A180 II 592.20 Supplementation of lactating motherswith lipid-based nutrient supplement does not infl uence infanthemoglobin levels during exclusive breastfeeding. E.M. Widen,L.S. Adair, M. Bentley, C. Chasela, D. Kayira, Z. Kacheche, G.Tegha, R.J. Knight, D.J. Jamieson and C.M. van der Horst.Univ. of North Carolina at Chapel Hill, Univ. of North CarolinaProject-Malawi, Principa, Chapel Hill and Ctrs. for Dis. Controland Prevent.A181 I 592.21 Associations of family cattle ownership,mother and father education, maternal depression, and socialsupport with anthropometric measures of breastfeeding infantsin rural Ethiopia T. Woltamo, L. Hubbs-Tait, D. Thomas, B.J.Stoecker and M. Hambidge. Oklahoma State Univ. and Univ.of Colorado Hlth. Sci. Ctr.A182 II 592.22 Maternal breastfeeding beliefs,appraisals, practices, and food insecurity infl uence qualityof breastfeeding interaction in Bangladesh A.L. Frith, E.A.Frongillo, R.T. Naved and M. Byrne. Ithaca Col., Univ. ofSouth Carolina, ICDDRB, Dhaka, Bangladesh and ColumbiaUniv. Sch. of Nursing.A183 I 592.23 Infant, maternal and sociodemographicrisk factors of prelacteal feeding in Nepal M.E. Henry, S.C.LeClerq, S.K. Khatry and P. Christian. Johns Hopkins Univ.Bloomberg Sch. of Publ. Hlth. and Nepal Nutr. Intervent. Project,Kathmandu.A184 II 592.24 Household and individual factorsassociated with undernutrition of children < 3 years from India.P. Chakraborty and A.K. Anderson. Univ. of Georgia.A185 I 592.25 Change in body composition of youngMalian children with moderate acute malnutrition over a 12-week dietary intervention. C. McDonald, R. Ackatia-Armah,R. Kupka, C. Duggan and K.H. Brown. Harvard Sch. of Publ.Hlth., Boston Univ. Sch. of Med., Helen Keller Intl., Bamako,Mali, UNICEF Reg. Ofc., Dakar, Senegal and Univ. of California,Davis.A186 II 592.26 A child feeding index is associatedwith child height-for-age in Bolivia and mothers’ index scoresshow improvement following an agriculture-centered nutritionintervention. A.D. Jones, P.R. Berti, Y. Cruz, P. Pinstrup-Andersen and J.D. Haas. Cornell Univ., HealthBridge, Ottawaand World Neighbors-Bolivia, Cochabamba.A187 I 592.27 Gender differences in childhoodstunting in southwestern Tanzania. C. McAuliffe, H. Zwickeyand E. Connelly. Rollins Sch. of Publ. Hlth., Emory Univ. andNatl. Col. of Nat. Med., OR.A188 II 592.28 Nutritional status of North Koreanchildren receiving long-term food aid. J-Y. Hwang, J. Lee, H.K.Chung and N. Chang. Ewha Womans Univ. and Hoseo Univ.,South Korea.A189 I 592.29 Comparison of new WHO criteriaversus former WHO and NCHSs criteria for screening anddiagnosis of moderate acute malnutrition among young childrenin rural Mali. R. Ackatia-Armah, C. McDonald, S. Doumbiaand K.H. Brown. Boston Univ. Sch. of Med., Helen Keller Intl.,Bamako, Harvard Sch. of Publ. Hlth., Univ. of Bamako, Mali andUniv. of California, Davis.A190 II 592.30 Development and growth in ruralVietnamese children: using the WHO motor milestone windowsof achievement and child growth standards. S. Kulkarni, U.Ramakrishnan, K.A. Dearden, D.R. Marsh and H. Pachon.Rollins Sch. of Publ. Hlth., Emory Univ., Boston Univ. Sch. ofPubl. Hlth., Save the Children Fed., Westport, CT and Intl. Ctr.of Trop. Agr., Cali, Colombia.A191 I 592.31 Anthropometry and body compositionamong highland and lowland children in Ecuador. F. Castillo,S.D. Katuli, L. Beeson and Z. Cordero-MacIntyre. LomaLinda Univ.A192 II 592.32 Understanding the factors, strategies,and processes conducive to the establishment of an effectiveglobal health partnership W. Gonzalez, E.A. Frongillo andJ.A. Rivera. Univ. of South Carolina and Natl. Inst. of Publ.Hlth., Cuernavaca, Mexico.A193 I 592.33 Happy is healthy: mothers’ perceptionsof a community nutrition intervention in Ecuador. M.L. Roche,J. Sarsoza, G.S. Marquis and H.V. Kuhnlein. McGill Univ.,Ste. Anne de Bellevue and World Vision Ecuador, Quito.593. COMPREHENSIVE WEIGHT MANAGEMENTPoster(Sponsored by: Medical Nutrition Council)NUTRITIONSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-1:45 PM (I); 1:45 PM-2:45 PM (II)A194 I 593.1 Differences in the psychopathologyof women with bulimia nervosa with or without a history ofoverweight or obesity. C. Cháirez-Jiménez, M. Kaufer-Horwitz,V. Vázquez-Velázquez, D. Gilbert-Acosta, I. Rocha-Velis, V.Soto-Fuentes and E. García-García. Salvador Zubiran Natl.Inst. of Med. Sci. and Nutr., Mexico City.A195 II 593.2 The effect of the family environmenton weight loss in early postpartum women. Y. Zhu, J. Lee,J.M. Cahill, B.V. Sanghani, D.M. Klohe-Lehman and J.H.Freeland-Graves. Univ. of Texas at Austin.A196 I 593.3 Including non-fat dairy in an energyrestricted,moderate-protein diet plan: two-week changes inbody weight and composition measurements in premenopausalwomen with overweight and obesity J.D. Shlisky, C.M.Durward, M.K. Zack, J.K. Campbell, S.S. Jonnalagadda andS.M. Nickols-Richardson. Penn State and Bell Inst. of Hlth.and Nutr., Minneapolis.A197 II 593.4 Effect of portion controlled frozenmeals on quality of life and diet quality during a communityintervention. K.J. Reimers and J. Rippe. ConAgra Foods,Omaha and Rippe Lifestyle Inst., Celebration, FL.A198 I 593.5 Central obesity depth: a promisingtool to assess abdominal adiposity. J.H. Freeland-Graves, Y.Zhu, J. Lee, M.R. Pepper, M. Yao and B. Xu. Univ. of Texas atAustin.A199 II 593.6 Multiple-pass 24-hours recallsignifi cantly predicts energetic restriction associated to weightloss. A. Suverza-Fernandez, K. Haua-Navarro, M.I. Gómez-Simón, T. Velasco-Canales and A.B. Pérez-Lizaur. Univ.Iberoamericana, Mexico.A200 I 593.7 The hamburger diet? Why hamburgersand apples lower total calorie intake. R.W. Patterson, B.Wansink and D.R. Just. Cornell Niv.SUN167
NUTRITIONA201 II 593.8 Secondary prevention of obesityamong children age 5 and under. C.M. Lenders, J.R. Heinricks,M.A. Debiasse and K. Gorman. Boston Univ. Sch. of Med.A202 I 593.9 Laparoscopic sleeve gastrectomy andnutritional status: a review. K. Rogoski, D. Anderson, P. Lalorand S. Houston. Bowling Green State Univ. and Wood CountyHosp.594. NUTRITION INTERVENTIONS FOR HEALTHPROMOTIONPoster(Sponsored by: Medical Nutrition Council)SUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-1:45 PM (I); 1:45 PM-2:45 PM (II)A203 I 594.1 Combination plant sterol/ezetimbetherapy in modulation of plasma lipids in Syrian goldenhamsters. T.C. Rideout, V.R. Ramprasath, V. Senanayakeand P.J. H. Jones. Univ. of Manitoba.A204 II 594.2 Algal extract and its sub-fractionsincrease plasma HDL-cholesterol via upregulation of ApoA1, ABCA1, and SRB1 and inhibition of CETB in hamsters A.Geamanu, A. Goja, N. Sadaat, M. Wadehra and X. Ji. WayneState Univ.A205 I 594.3 Effect of green tea polyphenols andTai Chi exercise on bone health in postmenopausal womenwith low bone mass: a 24-week placebo-controlled randomizedtrial. C-L. Shen, M-C. Chyu, J.K. Yeh, Y. Zhang, B.C. Pence,C.K. Felton, J-M. Brismee, R.Y. Dagda, S. Doctolero, M.J.Flores and J-S. Wang. Texas Tech Univ. Hlth. Sci. Ctr., TexasTech Univ., Winthrop-Univ. Hosp., Mineola, NY and Univ. ofGeorgia.A206 II 594.4 Effect of diets containing soy proteinisolate on bone formation are mediated through non-classicalestrogenic signaling in pre-pubertal rats. J. Zhang, O.P.Lazarenko, K. Shankar, T.M. Badger, M.J. Ronis and J-R.Chen. Univ. of Arkansas for Med. Sci.A207 I 594.5 A pilot study on vitamin D andtuberculin skin test conversion. D. Ganmaa, E. Giovannucci,M. Holick and W. Willett. Harvard Sch. of Publ. Hlth., Brighamand Women’s Hosp., Harvard Med. Sch. and Boston Univ. Med.Ctr.A208 II 594.6 Effects of seafood on fatty acid andmercury status. E.M. Janle, T.E. Petersen, W.W. Campbell,G.P. McCabe, J.W. Choi, R. Mobley, H.H. Freiser and C.R.Santerre. Purdue Univ. and Florida A&M Univ.A209 I 594.7 Impact of change in sugar-sweetenedbeverage intake on the 2005 Healthy Eating Index score inlower Mississippi Delta adults. J.L. Thomson, C. Connell,L.M. Tussing-Humphreys, S.J. Onufrak, J.M. Zoellner,H. Federico and K. Yadrick. USDA, Baton Rouge, Univ. ofSouthern Mississippi, USDA, Stoneville, MS and Virginia Tech.A2<strong>10</strong> II 594.8 Women with excess adiposity caninclude a daily sweet snack in a reduced-calorie diet to facilitateweight loss and improvements in blood pressure withoutadversely affecting lipid concentrations. K.E. Piehowski, S.M.Nickols-Richardson, A.G. Preston and D. Miller. Penn Stateand Hershey Ctr. for Hlth. and Nutr.A211 I 594.9 The effi cacy of ruby red grapefruitconsumption on weight, blood pressure, and lipid control inoverweight and obese adults C.A. Dow, B. Patil, J. Ravia andC. Thomson. Univ. of Arizona and Texas A&M Univ.A212 II 594.<strong>10</strong> Reduction of sodium in bakedproducts over the last decade. B. Showell and P. Pehrsson.USDA, Beltsville.A213 I 594.11 Relationship between perceivedstress and blood lipid levels among Haitian Americans with andwithout type 2 diabetes. N. Pinzon, J.M. Negron, G.G. Zariniand F.G. Huffman. Florida Intl. Univ.A214 II 594.12 Effi cacy of a strategy of schoolchildren’s feeding and physical activity behaviors relatedto overweight and obesity in Mexico. T. Shamah Levy, E.I.Escalante Izeta, C. Morales Ruan, C. Amaya Castellanosand A. Salazar Coronel. Natl. Publ. Hlth. Inst., Cuernavaca.A215 I 594.13 Overcoming nutritional neophobiawith strategies to introduce strange foods. S.V. Luna. CornellUniv.A216 II 594.14 Dietary nutrient intake affects calciumand magnesium metabolism. A. Fordyce, V. Gouliouk and R.I.Henkin. The Taste and Smell Clin., Washington, DC.595. NUTRITION AND INFLAMMATIONPoster(Sponsored by: Medical Nutrition Council)<strong>SUNDAY</strong>SUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-1:45 PM (I); 1:45 PM-2:45 PM (II)A217 I 595.1 Moderate zinc defi ciency increasesinfl ammation following traumatic brain injury in the rat. A.Scrimgeour, M.L. Condlin, E.C. Cope, A.J. Young and C.W.Levenson. U.S. Army Res. Inst. of Envrn. Med., Natick, MAand Florida State Univ. Col. of Med.A218 II 595.2 Circulating 25-hydroxyvitamin-D andinfl ammation in older community-dwelling adults. M.K. Shea,D.K. Houston, B.J. Nicklas, C.C. Davis, F-C. Hsu, J.A. Tooze,T.S. Church and S.B. Kritchevsky. Wake Forest Univ. andPennington Biomed. Res. Ctr., Baton Rouge.A219 I 595.3 Deglycosylation of fl avones enhancesanti-infl ammatory activity of food extracts in vitro and absorptionof dietary fl avones from celery in mice. G.L. Hostetler, K.M.Riedl, H. Cardenas, M. Diosa Toro, S.J. Schwartz and A.I.Doseff. Ohio State Univ.A220 II 595.4 A dietary pattern characterized byhigher intake of fruits and vegetables is inversely associatedwith infl ammatory markers in Latinos diagnosed with type 2diabetes. M.C. Calle, S. Vega-López, S. Segura-Pérez, J.S.Volek, R. Pérez-Escamilla and M.L. Fernandez. Univ. ofConnecticut, Arizona State Univ., Mesa, Hispanic Hlth. Council,Hartford and Sch. of Publ. Hlth., Yale Univ.A221 I 595.5 Serum carotenoids, but not fruit andvegetable intake, are inversely associated with serum hsCRPin Mexican-American adults G. Pereira-Pignotti, K.J. Farr,S. Neupane and S. Vega-López. Col. of Nursing and Hlth.Innovation, Arizona State Univ., Mesa.A222 II 595.6 PTX 3 concentration in relationto malnutrition—infl ammation syndrome in HD patients. W.Lysiak-Szydlowska and S. Malgorzewicz. Gdansk Med.Univ., Poland.168
<strong>SUNDAY</strong>A223 I 595.7 Low serum levels of glutathione,homocysteine and total antioxidant capacity are associatedwith increased risk of autism in Oman M.I. Waly, Y.M. Al-Farsi,M.M. Al-Sharbati, A. Ali, M.M. Al-Khalili, M.M. Essa, O.A. Al-Farsi and M.S. Al-Shafaee. Sultan Qaboos Univ., Oman.A224 II 595.8 Ferritin concentrations correlate withinfl ammatory makers and insulin resistance in type 2 diabetes.H-F. Chung, H-R. Jhang, K. Long, C-C. Hsu and M-C. Huang.Sch. of Popul. Hlth., Univ. of Queensland, Kaohsiung Med. Univ.Hosp., Natl. Hlth. Res. Inst., Zunan and Kaohsiung Med. Univ.,Taiwan.A225 I 595.9 Changes of interleukin 6 and n-3polyunsaturates and kidney function decline in type 2 diabetes.P-S. Chen, C-C. Hsu, H-R. Jhang, S-J. Hwang and M-C.Huang. Kaohsiung Med. Univ., Natl. Hlth. Res. Inst., Zunan andKaohsiung Med. Univ. Hosp., Taiwan.A226 II 595.<strong>10</strong> Diet effects the composition of themicrobial fl ora and infl ammation in the gut. J.H. Ooi, L.T. Rust,V. Holden, M. Wilke, G.K. Innes and M.T. Cantorna. PennState.A227 I 595.11 Diets high in saturated fat increaserisk for IBD in genetically susceptible hosts via induction ofimmunogenic microfl ora. S. Devkota, Y. Wang, D. Antonopoulosand E.B. Chang. Univ. of Chicago and Argonne Natl. Lab.A228 II 595.12 Plasma micronutrient concentrationsare associated with infl ammatory cytokine levels amongMexican women with greater abdominal fat and higher leptinlevels. K.Z. Long, O.P. Garcia, G. Zavala, M.C. Caamano, L.M.Salgado and J.L. Rosado. Univ. of Queensland Sch. of Popul.Hlth., Australia, Autonomous Univ. of Queretaro Sch. of Nat.Sci. and CICATA-IPN, Querataro, Mexico.A229 I 595.13 TOP 1 and 2, Taraxacum offi cinalepolysaccharide, inhibit LPS-stimulated infl ammatory mediatorsvia the NF-κB and Akt inactivation in RAW 264.7 cells C.M.Park, J.H. Shin, K.H. Min and Y.S. Song. Inje Univ., SouthKorea.A230 II 595.14 Tumeric extracts ameliorateinfl ammatory mediators through MAPKs and Akt inactivationsin LPS-stimulated RAW 264.7 cell line. J.H. Shin, C.M. Park,K.H. Min, K.H. Noh and Y.S. Song. Inje Univ., South Korea.A231 I 595.15 Percentage of weight loss andnutritional risk index in surgical patients: infl uence ofinfl ammation and usual weight. L. Zago, E. Danguise, C.González Infantino, M.E. Río and M. Callegari. Fac. of Pharm.and Biochem. And Hosp. Clins., Univ of Buenos Aires.A232 II 595.16 Treatment with ascorbic acid reducesadiponection levels in 3T3L1 adipocytes. V. Narayanan. FloridaIntl. Univ.A233 I 595.17 Effect of fructose on adiponectinlevels in 3T3-L1 adipocytes. V. Narayanan and D. Kumar.Florida Intl. Univ.A234 II 595.18 Mechanical ventilation inducesmyokine expression and catabolism in peripheral skeletalmuscle in pigs. R. Orellana, N. Srivastava, A. Suryawan, L.A.Center, H.V. Nguyen, R. Almonaci, S.J. Koo, M.C. Gazzaneo,R. Murgas Torraza, T.A. Davis and S.W. El-Kadi. Baylor Col.of Med.A235 I 595.19 Effects of chronic infl ammation onbone in mice. A. Girma, H. Nekatebeb, S. Peterson, Y. Wang,B.J. Smith and B.J. Stoecker. Oklahoma State Univ.A236 II 595.20 Effect of defatted green tea seedsupplementation on endotoxin-induced oxidative. J-H. Shin,B-Y. Seo, Y-S. Song and K-H. Noh. Inje Univ., South Korea.A237 I 595.21 Antioxidative and antiinfl ammatoryeffects of green tea seed coat extract in BALB/c mice injectedwith LPS. K-H. Noh, J-H. Shin, K-H. Min and Y-S. Song. InjeUniv., South Korea.A238 II 595.22 Soy protein diet inhibits zymosaninducedmonocyte migration. S. Nagarajan, J. Jordan, J.I.Warden and R.L. Burris. Univ. of Arkansas for Med. Sci. andArkansas Children’s Nutr. Ctr.596. ALIGNING NUTRITION EDUCATION PROGRAMSAND RESEARCH TO EFFECT CHANGEPoster(Sponsored by: Nutrition Education RIS)SUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-1:45 PM (I); 1:45 PM-2:45 PM (II)A239 I 596.1 Eating-competent, low-incomeparents model eating behaviors associated with reducing riskof child obesity B.A. Lohse and L. Cunningham-Sabo. PennState and Colorado State Univ.A240 II 596.2 A comparison of disturbed eatingbehaviors in young adults: implications for nutrition educationand counseling interventions. V. Quick and C. Byrd-Bredbenner. Rutgers Univ.A241 I 596.3 College-aged attitudes andperceptions toward nutrition: survey development. A.M. Readle,L. Kedem and K. Chapman-Novakofski. Univ. of Illinois,Urbana.A242 II 596.4 Impact of a dietary educationintervention on heart disease risk in college students. S.E.Hirshberg and I. Lofgren. Univ. of Rhode Island.597. EPIGENETICS AND NUTRITIONPoster(Sponsored by: Nutrient Gene Interactions RIS)NUTRITIONSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-1:45 PM (I); 1:45 PM-2:45 PM (II)A243 I 597.1 Evaluation of attitudes and knowledgeof fruit and vegetable consumption among second graders: thePick a Better Snack and Act Program. K. Inebnit, D. Gonzales,R. Rodibaugh and R. Hakkak. Univ. of Arkansas for Med.Sci.A244 II 597.2 Exercise preventshyperhomocysteinemia in a folate-restricted mouse model.J.C. Neuman, K.A. Albright and K.L. Schalinske. Iowa StateUniv.A245 I 597.3 Hepatic lipid accumulation inducesalterations of histone H3 lysine 4 and 9 trimethylation thatmodulate hepatic triglyceride synthesis in mouse primaryhepatocytes. H-j. Jun, J. Kim, J.H. Lee, Y. Jia and S-J. Lee.Korea Univ.A246 II 597.4 Adiposity, genetic and environmentalinfl uences on the association between sexual maturation andinsulin resistance in youth: a twin study in China J. Li, H. Liu, H.Chen and Y. Wang. Johns Hopkins Univ. and Jiaxing Maternityand Child Hlth. Care Hosp., People’s Republic of China.SUN169
NUTRITIONA247 I 597.5 CD36 polymorphisms are associatedwith fat discrimination, reported fat ingestive behaviors, andobesity in African Americans K.L. Keller, L.C. H. Liang, J.McLean, D. May, C. Breen, E. Driggin, B.J. Tepper, P.C.Lanzano, L. Deng and W.K. Chung. St. Luke’s RooseveltHosp., NY, Rutgers Univ. and Columbia Univ. Col. of P&S.A248 II 597.6 Folate modulation of adipocytepromoter methylation and lipolysis. J.S. Gouffon, M. Johnstoneand M.B. Zemel. Univ. of Tennessee, Knoxville.A249 I 597.7 Epigenetic synergies betweenmethylation of cytosines and biotinylation of histones in generepression. J. Xue and J. Zempleni. Univ. of Nebraksa-Lincoln.A250 II 597.8 Resveratrol prevents epigeneticsilencing of BRCA-1 by the activated AhR in breast cancercells. A.J. Papoutsis, J. Borg, O. Selmin and D. Romganolo.Univ. of Arizona.598. DIET AND DNA METHYLATIONPoster(Sponsored by: Nutrient Gene Interactions RIS)SUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-1:45 PM (I); 1:45 PM-2:45 PM (II)A251 I 598.1 Sulforaphane modulates DNAmethylation of gene promoters. J.M. Cramer, P.L. Jones andE.H. Jeffery. Univ. of Illinois at Urbana-Champaign and BostonBiomed. Res. Inst.A252 II 598.2 Effects of arsenic exposure andfolate defi ciency on methyl metabolism in human fi broblastcell lines. A. Chango, S. Bousserouel, E.Z. Gnimpieba, A.M.Abdel Nour and L. Abdennebi-Najar. Polytech Inst. LasalleBeauvais, France.A253 I 598.3 A western style diet reduces genomicDNA methylation and aging increases p16 promoter DNAmethylation in mouse colon. S. Tammen, E. Zimmerly, S.Ledbetter, L.K. Park and S-W. Choi. USDA at Tufts Univ.599. DIETARY BIOACTIVES AND GENE EXPRESSIONPoster(Sponsored by: Nutrient Gene Interactions RIS)SUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-1:45 PM (I); 1:45 PM-2:45 PM (II)A254 I 599.1 The lifespan-extending effect ofCordyceps sinensis Cs-4 in normal mice and its molecularmechanisms. N-Z. Tan, J.L. Barger, Y. Zhang, S.B. Ferguson,Z-M. Wu, T.A. Prolla, M. Bartlett and J-S. Zhu. PharmanexBeijing Pharmacol. Ctr., LifeGen Technol., Madison, WI and NuSkin Ctr. for Anti-aging Res., Provo, UT.A255 II 599.2 Cross-talk between AMPK and GSK3βor CSK in selenium- or EGCG-treated hepatocarcinoma cells.S.Y. Park, Y-K. Lee, Y.M. Kim and O.J. Park. Hannam Univ.,South Korea and SUNY Downstate Med. Ctr.A256 I 599.3 Rational gene targeting with healthydietary supplements to clinically immunosuppress and treatDown syndrome. S.F. Hushmendy, T. Renna, D. Bhoiwala, A.Mathew, P. Zmijewski and D. Crawford. Albany Med. Col.A257 II 599.4 Gene expression and pathwaychanges after n-3 PUFA supplementation in healthy subjects. I.Rudkowska, A-M. Paradis, E. Thifault, P. Julien, P. Couture,S. Lemieux and M-C. Vohl. Laval Univ. Med. Ctr., Canada.A258 I 599.5 A higher maternal choline intakefavorably alters placental gene expression of biologicalpathways related to disease risk. X. Jiang, J. Yan, A. West,C. Perry, O. Malysheva, H. Bar, M. Wells, S. Devapatla, E.Pressman and M. Caudill. Cornell Univ., Cayuga Med. Ctr.,Ithaca and Univ. of Rochester Med. Ctr.A259 II 599.6 Alleviation of bowel infl ammation bydietary phenethylisothiocyanate in a mouse ulcerative colitismodel. M. Dey, Y. Liu, K. Reuhl, I. Raskin, D. Ribnicky and P.Kuhn. South Dakota State Univ. and Rutgers Univ., Piscatawayand New Brunswick.A260 I 599.7 Effect of fi sh oil supplementation onlipogenic gene expression in mammary gland and liver in mice.M. Hussein, K.J. Harvatine, Y.R. Boisclair and D.E. Bauman.Cornell Univ. and Penn State.A261 II 599.8 A high fat/high fructose diet hasnegative effects on brain insulin signaling that are improved bycinnamon. B. Qin, F. Canini, A.M. Roussel and R.A. Anderson.USDA, Beltsville, CRASSA Army Res.Ctr., Grenoble andINSERM 884, Joseph Fourier Univ., Grenoble.A262 I 599.9 LXRα activity on lipogenic andreverse cholesterol tansport genes is differentially regulated bysoy protein isofl avones. O. Granados, V. Ortiz, N. Torres andA.R. Tovar. Salvador Zubirán Natl. Inst. of Med. Sci. and Nutr.,Mexico City.A263 II 599.<strong>10</strong> Effect of hesperidin and naringinon plasma lipid and insulin sensitivity in rats fed high-fat or/and high-fructose diet. M-Q. Zaman, V. Leray, J. Lebloc’h, K.Ouguerram and P. Nguyen. Oniris, Vet Nantes and INSERMUMR 915, Nantes.600. INNOVATIVE DIETARY ASSESSMENTTOOLS (INCLUDING USE OF IMAGE ANDVISUALIZATION METHODS)Poster(Sponsored by: Nutritional Epidemiology RIS)<strong>SUNDAY</strong>SUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-1:45 PM (I); 1:45 PM-2:45 PM (II)A264 I 600.1 Assessing adults’ dietary intake,utilizing the National Cancer Institute’s automated selfadministered24-hour dietary recall, in virtual learningenvironments K.S. Stote, P. Carrico and R. Cole. SUNYEmpire State Col. and Army Med. Dept. Ctr. & Sch., Fort SamHouston.A265 II 600.2 Antioxidant food frequencyquestionnaire in healthy young adults: validity and reproducibility.M. Yang, Y. Wang, C.G. Davis, S-G. Lee, W.O. Song and O.K.Chun. Univ. of Connecticut and Michigan State Univ.A266 I 600.3 Using urinary nitrogen and urea topredict dietary protein intake: a controlled clinical trial. J.D.Bihuniak, C.A. Simpson, R.R. Sullivan, J.E. Kerstetter andK.L. Insogna. Univ. of Connecticut and Yale Univ.170
<strong>SUNDAY</strong>A267 II 600.4 Number of households andassessments required for accurate measurement of selectednutrients in foods in the home. J. Stevens, J. Cai, L. Wang, M.Bryant and M.E. Bentley. Univ. of North Carolina at ChapelHill and Univ. of Leeds.A268 I 600.5 Validation and application ofantioxidant food frequency questionnaire in overweightpostmenopausal women. M. Yang, Y. Wang, C.G. Davis, S-G.Lee, A. Kenny, W.O. Song and O.K. Chun. Univ. of Connecticut,Univ. of Connecticut Hlth. Ctr. and Michigan State Univ.A269 II 600.6 Web-based 24-hour recalls are asvalid for African Americans as for Caucasians. L. Arab, P.Jardack, K. Wesseling-Perry, A. Ang and C-h. Tseng. UCLADavid Geffen Sch. of Med.601. RESEARCH WITH DIETARY SUPPLEMENTATIONPoster(Sponsored by: Nutritional Epidemiology RIS)SUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-1:45 PM (I); 1:45 PM-2:45 PM (II)A270 I 601.1 Chromium is not an essential elementfor mammals: effects of a low-chromium diet. J.B. Vincent, K.R.Di Bona, S. Love, N.R. Rhodes, D. McAdory, S.H. Sinha, J.Ramage and J.F. Rasco. Univ. of Alabama.A271 II 601.2 ReishiMax extends the lifespan ofmice: a preliminary report. Z. Wu, Y. Zhang, N-Z. Tan, C. Zhao,J. Yang and J-S. Zhu. Pharmanex Beijing Pharmacol. Ctr. andNu Skin Ctr. for Anti-Aging Res., Provo, UT.A272 I 601.3 Emerging health-promoting effects ofsilicates: results from in vivo experiments. S. Neely, N. Swift,D. Townsend, G. Agbley, L. McMillin, B. Jamison, W. Agee,V. Maitin, S. Deusler, I. Cisneros, C.R. Richardson and D.Vattem. Texas State Univ., San Marcos and Cisne EnterprisesInc., Odessa, TX.A273 II 601.4 Determination of cyanocobalamin inmultivitamin dietary supplement tablets and infant formulas. P.Chen, J. Sun and W. Wolf. USDA, Beltsville.A274 I 601.5 Preliminary evaluation of omega-3dietary supplement label information for products in the DietarySupplement Ingredient Database. A. Middleton, K. Andrews,J. Roseland, C. Zhao, J. Holden, J. Dwyer and L.G. Saldanha.USDA, Beltsville and ODS, NIH.A275 II 601.6 The Dietary Supplement IngredientDatabase: labeled nutrient distribution in children’s multivitamin/mineral products. C. Zhao, J. Roseland, K. Andrews, J.Holden, A. Middleton, J. Dwyer, R. Bailey and L. Saldanha.USDA, Beltsville and ODS, NIH.A276 I 601.7 Safety assessment of edible bluegreen algae, Nostoc commune var. sphaeroides Kützingand Spirulina plantensis Y. Yang and J-Y. Lee. Univ. ofConnecticut.A277 II 601.8 Evaluation of creatine as potentialtherapy for treating manganese neurotoxicity. S. Farah,S.C. Fordahl and K.M. Erikson. Univ. of North Carolina atGreensboro.A278 I 601.9 Efficacy and tolerability of Merastin —a novel herbal formulation for weight management: a randomizeddouble blind placebo controlled clinical study. D. Bagchi, F.C.Lau, T. Golakoti, A.V. Krishnaraju and K. Sengupta. InterHlth.Nutraceut., Benicia, CA Univ. of Houston Col. of Pharm. andLaila Nutraceut., Vijayawada, India.A279 II 601.<strong>10</strong> Effi cacy of LOWAT — a natural weightmanagement herbal formulation in obese human subjects.D. Bagchi, F.C. Lau, T. Golakoti, A.V. Krishnaraju and K.Sengupta. InterHlth. Nutraceut., Benicia, CA, Univ. of HoustonCol. of Pharm. and Laila Nutraceut., Vijayawada, India.A280 I 601.11 Effects of different types of fator carbohydrate sources on hyperlipidemia and obesity inlaboratory animals. W.S. Lee, J.C. An, M.R. Heo and S.G.Hwang. Hankyong Natl. Univ., South Korea.602. APPLICATIONS AND CHALLENGES OF PUBLICUSE DATA SETS FOR SECONDARY DATAANALYSIS NUTRITION RESEARCHPoster(Sponsored by: Nutritional Epidemiology RIS)SUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-1:45 PM (I); 1:45 PM-2:45 PM (II)A281 I 602.1 Nutritional contributions of lean pork tothe diets of adults in the U.S. M.M. Murphy, X. Bi, C. Scrafford,J.S. Douglass and L.M. Barraj. Exponent Inc., Washington,DC.A282 II 602.2 Association of dietary pattern andCVD risk factors in Korean adults. Y-H. Park, J-Y. Lee, M-S.Kang and J-S. Choi. Natl. Acad. of Agr. Sci., Suwon, SouthKorea.603. ASSESSMENT OF CHILD AND ADOLESCENTNUTRITIONAL STATUS, GROWTH AND OBESITYPoster(Sponsored by: Nutritional Epidemiology RIS)NUTRITIONSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-1:45 PM (I); 1:45 PM-2:45 PM (II)A283 I 603.1 Children’s body mass index andschool meal participation during the 4th-grade school year. A.Paxton, S.D. Baxter, J.A. Royer, C.H. Guinn and C.M. Delvin.Univ. of South Carolina.A284 II 603.2 Nutritional status of children andadolescents with diabetes mellitus and associated factors.E. Romero-Velarde, L. Valadez-Alvarez, E.M. Vasquez-Garibay, M.E. Milke-Najar and L.M. Aguirre-Salas. Univ. ofGuadalajara.A285 I 603.3 Are different infant feeding patternsassociated with later health outcomes in early childhood?—NHANES (2001–2006). B.P. Marriott, C. Williams, L. Haddenand J. Wallingford. Samueli Inst., Alexandria, VA, Univ. ofNorth Carolina at Chapel Hill, Abt Assocs., Durham, NC andPfi zer Nutr., Collegeville, PA.SUN171
NUTRITIONA286 II 603.4 Overweight Hispanic infants in anurban area: saturated fat as a contributing factor. C. Espinosa,I. Ramos, J. Collado and J. Worobey. Rutgers Univ.A287 I 603.5 Nutritional assessment of children withdevelopmental disorders over a <strong>10</strong> year period. S.M. Ekvall, P.Fugazzi, F. Stevens and V. Ekvall. Cincinnati Children’s Hosp.Med. Ctr. and Univ. of Cincinnati.A288 II 603.6 Between-population differences inlinear growth among adolescents. Y. Choi, X. Chen and Y.Wang. Johns Hopkins Bloomberg Sch. of Publ. Hlth.A289 I 603.7 Secular trends since the 1970s andracial/ethnic and SES disparities in linear (height) growth inU.S. children and adolescents. Y. Wang and T.T. Nguyen.Johns Hopkins Bloomberg Sch. of Publ. Hlth.A290 II 603.8 Waist circumference, but waist-heightratio, underestimates cardiometabolic risk in stunted childrenM. Kroker, K. Schlosser and M. Ramírez-Zea. INCAP,Guatemala City.A291 I 603.9 Measurements and predictors ofphysical activity among toddlers. L.W. Latta, E.R. Hager, E.Kim, L.E. Caulfield and M.M. Black. Univ. of Maryland Sch. ofMed. and Johns Hopkins Bloomberg Sch. of Publ. Hlth.A292 II 603.<strong>10</strong> Assessing dietary intake amonginfants and toddlers 0–24 months of age in Baltimore,Maryland S. Sharma, J.L. Butler, N. Budd, Y.T. Chinyanga, B.Rushovich, G.L. Mukhina, J. Gittelsohn and B. Caballero.Univ. of Alberta, Johns Hopkins Univ. Bloomberg Sch. of Publ.Hlth. and Sch. of Med. and Univ. of Maryland Sch. of SocialWork.A293 I 603.11 Nutrient intake of WIC infants by childcare and parent care. R.A. Mathai and J. Kim. Univ. of Illinoisat Urbana-Champaign.A294 II 603.12 Differences in diet quality betweenweekdays and weekends: utility of a random effects model.T.R. Nansel, A. Liu, L. Lipsky, D.L. Haynie, S.N. Mehta andL.M. B. Laffel. Eunice Kennedy Shriver NICHD, NIH and JoslinDiabetes Ctr., Boston.A295 I 603.13 Prevalence of nutrient adequacy forU.S. infants and toddlers, NHANES 2003-2006 C.S. Chung, W.Juan, S. Yamini and P. Trumbo. FDA, College Park, MD.A296 II 603.14 Increased fruit and vegetableconsumption is related to reduced dietary energy density andimproved weight status in U.S. children. J.A. Vernarelli, D.C.Mitchell, T.J. Hartman and B.J. Rolls. Penns State.A297 I 603.15 Vitamin D insuffi ciency limits bonemineral adequacy in Brazilian adolescent boys. B.F. Moura, P.Normando, A.C. Costa and F.F. Bezerra. Univ. do Estado ofRio de Janeiro.A298 II 603.16 Impaired vitamin D synthesis andintestinal Ca transport compromise growth in fructose-fedyoung rats. V. Douard, J. Lee, Y. Sabbagh, S.A. Shapses, S.S.Lin and R.P. Ferraris. UMDNJ, Newark, Genzyme Corp. andRutgers Univ.A299 I 603.17 Accuracy of anthropometricparameters as indicators of abdominal adipose tissue:comparisons of the areas under receiver operating characteristiccurves using a nonparametric approach. J. Liu, W.D. May, C.S.Fox, A. Penman, P.M. Dubbert, J.G. Wilson and H.A. Taylor.Univ. of Mississippi Med. Ctr., NHLBI-Framingham Heart Studyand South Central VA Mental Illness Res. and Educ. and Clin.Ctr., North Little Rock.A300 II 603.18 Relationship between life style, bodymass index and body image in a group of university students A.Suverza-Fernandez, M. Ruiz-Muñoz and K. Haua-Navarro.Ibero-American Univ., Mexico.A301 I 603.19 Maternal vitamin D status ofadolescent mothers at mid-pregnancy infl uence bone mineralcontent of their newborns. M. E.L. Diogenes, F.F. Bezerra, E.P.Rezende, M.F. Taveira, I. Pinhal and C.M. Donangelo. Fed.Univ. of Rio de Janeiro, Univ. do Estado of Rio de Janeiro andUniv. of the Republic, Uruguay.604. BEVERAGE CONSUMPTION IN NATIONALLYREPRESENTATIVE U.S. SAMPLESPoster(Sponsored by: Nutrition Epidemiology RIS)SUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-1:45 PM (I); 1:45 PM-2:45 PM (II)A302 I 604.1 <strong>10</strong>0% Fruit juice and humanhealth: a critical review. D.A. Hyson. California State Univ.,Sacramento.A303 II 604.2 The impact of beverage type intakeon energy intake and weight in 12-month-old Hispanic infants.C. Espinosa, I. Ramos, P. Barrios, J. Pena and J. Worobey.Rutgers Univ.605. GENE ENVIRONMENT INTERACTIONS INOBESITYPoster(Sponsored by: Obesity RIS)<strong>SUNDAY</strong>SUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-1:45 PM (I); 1:45 PM-2:45 PM (II)A304 I 605.1 Sugar solutions alter liver andhypothalamic appetite regulation. T.W. Castonguay, E.London, J. Khural and B. Jiang. Univ. of Maryland CollegePark.A305 II 605.2 Eating competence is related toPPARβ/δ and PCG-1α genotypes. B.A. Lohse, J. VandenHeuvel, J.S. Krall, J. Patterson, K. Kattelmann, A.A. Whiteand G. Greene. Penn State, Univ. of Pittsburgh Med. Ctr.,South Dakota State Univ., Univ. of Maine and Univ. of RhodeIsland.A306 I 605.3 Stress and obesity — Bardet Biedlsyndrome model. R. Birk and N. Bozer. Ariel Univ. Ctr. andBen-Gurion Univ., Beer Sheva, Israel.A307 II 605.4 Effect of maternal obesity on fetal bonedevelopment in the rat. J-R. Chen, J. Zhang, O.P. Lazarenko,R.A. Wynne, M.L. Blackburn, M.J. Ronis, K. Shankar andT.M. Badger. Univ. of Arkansas for Med. Sci.A308 I 605.5 Cardiac lipotoxicity is greater incystathionine-β-synthase defi cient mice with diet-inducedobesity. M.B. Glier, D.C. Sulistyoningrum, E. Wang, S. Ghoshand A.M. Devlin. Univ. of British Columbia and Univ. of BritishColumbia Okanagon.172
<strong>SUNDAY</strong>606. MUSCLE METABOLISM, EXERCISE ANDOBESITYPoster(Sponsored by: Obesity RIS)SUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-1:45 PM (I); 1:45 PM-2:45 PM (II)A309 I 606.1 Role of mTOR and β-hydroxy-βmethylbutyratein leucine stimulation of muscle mitochondrialbiogenesis and fatty acid oxidation. R.A. Stancliffe, M. Eades,K. Smart and M.B. Zemel. Univ. of Tennessee, Knoxville.A3<strong>10</strong> II 606.2 Step counts from two new systemsduring treadmill walking in children and adults. L. Lanningham-Foster, R. Foster, M. Barnes, E. Kracke, S. Kling and M. Vik.Iowa State Univ.607. IRONPoster(Sponsored by: Vitamins and Minerals RIS)SUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-1:45 PM (I); 1:45 PM-2:45 PM (II)A311 I 607.1 Oral NaFeEDTA or iron polymaltosesupplements mitigate exposure to post-dose nontransferrinbondiron, independent of iron status/gender M.N. Orozco, M.E.Romero-Abal, N.W. Solomons, G. Weiss and K. Schümann.CeSSIAM, Guatemala City, Med. Univ. of Innsbruck and Tech.Univ. of Munich, Freising-Weihenstephan.A312 II 607.2 The circulating nontransferrin-bondiron response to <strong>10</strong>0 mg of ferrous sulfate iron is unrelatedto iron status or gender. M.N. Orozco, N.W. Solomons, K.Schümann, M.E. Romero-Abal and G. Weiss. CeSSIAM,Guatemala City, Tech. Univ. of Munich, Freising-Weihenstephanand Med. Univ. of Innsbruck.A313 I 607.3 Iron status declines in male soldiersduring military training despite increased dietary iron intake.J.P. McClung, J.P. Karl, L.J. Bass, J.C. Rood, B.C. Wiley, S.J.Cable, K.W. Williams and A.J. Young. U.S. Army Res. Inst. ofEnvrn. Med., Natick, MA, Pennington Biomed. Res. Ctr., BatonRouge and Directorate of Basic Combat Training, Fort Jackson,SC.A314 II 607.4 Moderate endurance exercise affectshepcidin and IL-6 levels in healthy young men. N.E. Andersen,H.L. McClung, R.A. Fielding, J.P. McClung, A.J. Young andS.M. Pasiakos. U.S. Army Res. Inst. of Envrn. Med., Natick, MAand USDA at Tufts Univ.A315 I 607.5 Association between maternal ironintake on fetal growth: Mothers and Children’s EnvironmentalHealth study. J. Lee, J-Y. Hwang, J. Hur, Y.A. Lee, E-H. Ha, H.Park, M. Ha, Y. Kim, Y-C. Hong and N. Chang. Ewha WomansUniv., Ewha Womans Univ. Col. of Med., Dankook Univ. Col. ofMed., Ulsan Univ. Hosp., Univ. of Ulsan Col. of Med., and SeoulNatl. Univ. Col. of Med., South Korea.A316 II 607.6 Iron increases the uptake of ascorbateand the expression of its transporter SVCT1. N.M. Scheersand A-S. Sandberg. Chalmers Univ. of Technol., Sweden.NUTRITIONA317 I 607.7 Characteristics of the diet and ironoverload risk in a group of healthy adult males from Argentina.M. Castro, J.A. Rey, M.M. Lardo, M.F. Ceballo, A. Lazarowskiand S.H. Langini. Univ. of Buenos Aires.A318 II 607.8 Iron bioavailability in lentil-baseddiets: studies in poultry and in vitro digestion/Caco-2 model.E. Tako, A. Vandenberg, D. Thavarajah, P. Thavarajah andR.P. Glahn. USDA, Ithaca, Univ. of Saskatchewan and NorthDakota State Univ.A319 I 607.9 A high protein diet does not enhancethe anemia mitigating effect of resistance exercise in rats. T.Fujii, T. Asai, T. Matsuo and K. Okamura. Osaka Univ. of Hlth.and Sport Sci. and Kagawa Univ., Japan.A320 II 607.<strong>10</strong> Adjusting plasma ferritinconcentrations in the presence of subclinical infl ammation toimprove the estimate of response to an iron intervention. E.Bielecki, J.D. Haas, S. Villalpando and E. Boy. Cornell Univ.,Natl. Inst. of Publ. Hlth., Cuernavaca and HarvestPlus/Intl. FoodPolicy Res. Inst., Ottawa.A321 I 607.11 Serum haptoglobin: a marker ofmaternal obesity and neonatal iron status. C. Cao, M. Young, T.Kent, E. Cooper, E. Pressman, A.W. McIntyre, T. McNanley,M. Westerman, R. Guillet and K. O’Brien. Cornell Univ., Univ.of Rochester Sch. of Med. and Intrinsic LifeSci., La Jolla.A322 II 607.12 Transcriptional regulation of theMenkes copper ATPase (Atp7a) gene by perturbations of ironand copper in intestinal epithelial cells. L. Xie and J. Collins.Univ. of Florida.A323 I 607.13 Placental heme oxygenase-2expression in pregnant adolescents is related to placentaliron content and FLVCR expression. T. Bemis, M. Foehr, L.Jaacks, T.J. McNanley, E.M. Cooper, E.K. Pressman, A.W.McIntrye, J.L. Abkowitz, R. Guillet and K.O. O’Brien. CornellUniv., Univ of Rochester Sch. of Med.and Univ. of Washington.A324 II 607.14 Coordination of iron and oxygensensing through posttranscriptional regulation of EPAS1. M.R.Davis, E. Rendina, E.A. Lucas, B.J. Smith and S.L. Clarke.Oklahoma State Univ.A325 I 607.15 Identifi cation of residues required foriron transport activity of the transmembrane protein Zip14. S.Jenkitkasemwong and M.D. Knutson. Univ. of Florida.A326 II 607.16 Effect of dietary iron defi ciency andoverload on Zip14 levels in rats. H. Nam and M.D. Knutson.Univ. of Florida.A327 I 607.17 Heme boosts non-heme ironabsorption in human intestinal Caco-2 cells. Q. Ma, E-Y. Kimand O. Han. Penn State.A328 II 607.18 Mathematical model of iron absorptionbased on biochemistry of absorption. L. Miller, N.F. Krebs andK.M. Hambidge. Univ. of Colorado Denver, Aurora.A329 I 607.19 Neurophysiological consequences ofiron defi ciency. L.E. Murray-Kolb, M.J. Wenger and Q. Yang.Penn State, Univ. of Oklahoma and Penn State Hershey.A330 II 607.20 Analytic measures of perceptual andcognitive performance in measuring effects of dietary ironrepletion. M.J. Wenger, L.E. Murray-Kolb, J.E. Hammons,S. Venkatramanan and J.D. Haas. Univ. of Oklahoma, PennState, Cornell Univ. and McGill Univ. Sch. of Dietetics andHuman Nutr.A331 I 607.21 Identifi cation of novel Menkes copperAtpase (Atp7a) splice and immunoreactive protein variants. C.Kim, Y. Lu, L. Jiang, L. Xie and J.F. Collins. Univ. of Florida.SUN173
NUTRITIONA332 II 607.22 Estimation of serum ferritin levelsaccounting for C-reactive protein concentrations in Mexicanpopulation. V.V. De la Cruz, S. Villalpando, A. Salinas, E.Gutiérrez and B. Trejo. Natl. Inst. of Publ. Hlth., Cuernavaca,Mexico.A333 I 607.23 Iron bioavailability of the diets ofCanadians. M.R. L’Abbe, Y. Qi, M. Cooper and W. Lou. DallaLana Sch. of Publ. Hlth., Univ. of Toronto and Hlth. Canada,Ottawa.608. MICRONUTRIENT INTERVENTIONSPoster(Sponsored by: Vitamins and Minerals RIS)SUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-1:45 PM (I); 1:45 PM-2:45 PM (II)A334 I 608.1 Effect of calcium supplementation oncycling performance in <strong>10</strong> mile time trials. R. Jawadwala, S.Atkins, N. Lowe and P. Robinson. Univ. of Chester and Sch.of Psychol., Univ. of Central Lancashire, U.K.A335 II 608.2 A potential new role for the B vitamin5-methyl-tetrahydrofolate in human skin. L.Z. Hasoun, S.W.Bailey, K.K. Outlaw and J.E. Ayling. Univ. of South Alabamaand Mobile Infi rmary.A336 I 608.3 Metabolic studies of pyridoxamine(vitamin B6) metabolism in rats. K.L. Ericson, S.P. Coburn,M.A. Gallant, S. Reinwald and D.B. Burr. Indiana Univ.-Purdue Univ. Fort Wayne and Indiana Univ. Sch. of Med.A337 II 608.4 Vitamin D sub-set analysis fromthe FLASH study — a longitudinal college student cohort. M.Bishop, A.Y. McDermott, A. Nazmi, C. Stephensen and L.Hall. Cal Poly State Univ., San Luis Obispo and USDA, Univ. ofCalifornia, Davis.609. NUTRIENT DATA METHODS AND QUALITYPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-1:45 PM (I); 1:45 PM-2:45 PM (II)A338 I 609.1 Microbiological assay of folate infoods containing a high level of fats. T. Hyun, J. Song, H-B.Jang, Y-H. Han and T. Tamura. Chungbuk Natl. Univ., SouthKorea and Univ. of Alabama at Birmingham.A339 II 609.2 The effect of bleaching treatments onpistachio lipid peroxidation, phytosterol content, and cytotoxicityof Hepa1c1c7 cells K. Racicot, A. Craven and C-Y.O. Chen.USDA at Tufts Univ. and Ridgeline Svcs., Atascadero, CA.A340 I 609.3 Effect of draining and rinsing on thesodium and water soluble vitamin content of canned vegetables.D.B. Haytowitz. USDA, Beltsville.A341 II 609.4 Nutrient data for whole, large eggsfrom a USDA nationwide sampling J. Exler, K.Y. Pattersonand J.M. Holden. USDA, Beltsville.A342 I 609.5 Carotenoids and folate vitamers inindigenous plants consumed by Northern Plains Americanindians. P. Pehrsson, A. Scheett, K. Phillips, K. Pattersonand H. Lukaski. USDA, Beltsville and Grand Forks and VirginiaTech.<strong>SUNDAY</strong>A343 II 609.6 Challenges and results of samplingChinese restaurant menu items for the USDA National NutrientDatabase for Standard Reference. R.G. Thomas and S.E.Gebhardt. USDA, Beltsville.A344 I 609.7 Extension of a LC-UV/fl uorescence/mass spectrometry method for vitamin b6 in dietary supplementsto additional formulations. R.J. Goldschmidt, W.R. Wolf and R.Atkinson. USDA, Beltsville.A345 II 609.8 Physical characteristics, dietaryhabits and nutrient intake of male college students according totheir majors K.O. Shin, T.H. Jung, K.S. Choi and K.H. Chung.Sahmyook Univ., South Korea.A346 I 609.9 Evaluation of the smoking anddrinking habits of male college students according their majors.K.O. Shin, T.H. Jung, H.J. Hwang, K.S. Choi and K.H. Chung.Sahmyook Univ., South Korea.A347 II 609.<strong>10</strong> Study on differences in dietary habitsand nutrient intake between lacto-ovo vegetarian and nonvegetarianelementary school children. K.O. Shin, T.H. Jung,K.H. Chung and K.S. Choi. Sahmyook Univ., South Korea.A348 I 609.11 Comparison of two feeding regimenson peripheral vascular function and biomarker variability. Y. Liu,D.L. Daleke and A.D. Fly. Indiana Univ.A349 II 609.12 Withdrawn.A350 I 609.13 Development of a clinical nutritionsupport system for chronic kidney disease. S-T. Wang, C-Y.Hsu, L-F. Chen and A. Kumar. Col. of Med. Sci. and Technol.,Taipei Med. Univ. and Ctr. of Excellence for Cancer Res.,Taipei.A351 II 609.14 Characterization of self-reportedasthma in morbidly obese women. A.R. Johnson, M. Proctor,A. Bilderback, C.S. Rand and E.M. Clerisme-Beaty. BarryUniv., FL and Johns Hopkins Univ.A352 I 609.15 The effect that the fractions reachesto the antiobesity biomarker in 3T3-L1 cells when partitioningthe green pepper water extracts according to a solvent. J.M.Baek, T.W. Kim, T.H. Kim and M. Choe. Kangwon Natl. Univ.,South Korea.A353 II 609.16 Distinctive effects of plant proteins onrenal disease progression and associated cardiac hypertrophyin experimental polycystic kidney disease. H. Aukema,J. Gauther, M. Roy, Y. Jia, H. Li and R. Aluko. Univ. ofManitoba.A354 I 609.17 Total antioxidant capacity ofcommonly consumed kids’ beverages in the U.S. M.Y. Hongand L. Mansour. Sch. of Exercise and Nutr. Sci., San DiegoState Univ.A355 II 609.18 Permeability of Echinacea alkylamidesand ketones across Caco-2 cell monolayers. Z. Qiang, C.Hauck, P. Murphy, L. Qu, M.P. Widrlechner, M.B. Reddy andS. Hendrich. Iowa State Univ.A356 I 609.19 Associations between plasmamicronutrients concentrations with overweight and obesity inchildren from rural Mexico. O.P. García, D. Ronquillo, L.V.López, M.C. Caamaño and J.L. Rosado. Autonomous Univ.of Queretaro and Cindetec A.C., Queretaro, Mexico.174
NUTRITION/PATHOLOGY6<strong>10</strong>. UNDERSTANDING AND COMMUNICATINGBENEFITS/RISKS OF NATURAL-STATE FOODS[E.G. MINIMALLY PROCESSED, NATURAL,ORGANIC]Poster(Sponsored by: Nutrition Translation from Bench toConsumer RIS)SUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-1:45 PM (I); 1:45 PM-2:45 PM (II)A357 I 6<strong>10</strong>.1 Traditional bean and rice mealsreduce postprandial glycemia in adults with type 2 diabetes.S.V. Thompson, D.M. Winham and A. Hutchins. ArizonaState Univ., Mesa and Univ. of Colorado at Colorado Springs.A358 II 6<strong>10</strong>.2 You taste what you see: organic labelsfavorably bias taste perceptions. J.W-c. Lee, M. Shimizu andB. Wansink. Cornell Univ.611. ZINCPoster(Sponsored by: Vitamins and Minerals RIS)SUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-1:45 PM (I); 1:45 PM-2:45 PM (II)A359 I 611.1 Zinc-defi ciency enhances sensitivityto carbon tetrachloride-induced hepatotoxicity in rats. A.Kojima-Yuasa, K. Kamatani, M. Tabuchi, Y. Akahoshi and I.Matsui-Yuasa. Grad. Sch. of Human Life Sci., Osaka City Univ.,Kinki Univ. Life Sci. Res. Inst. and Sch. of Med. and WakayamaUniv., Japan.<strong>SUNDAY</strong>A360 II 611.2 Effect of plasma zinc levels onmorbidity in HIV-infected persons in Miami. L. Garces, A.Campa, S.S. Martinez, S. Lai, Y. Li, J.B. Page and M.K. Baum.Florida Intl. Univ., Johns Hopkins Univ. and Univ. of Miami.A361 I 611.3 ZnT4 is localized to the trans-Golgiapparatus and contributes to zinc secretion from mammaryepithelial cells. N.H. McCormick and S.L. Kelleher. PennState.A362 II 611.4 Proteomic analysis of serum fromearly pubertal females supplemented with zinc. A. Grider, L.L.Atwell, R.D. Lewis, E.M. Laing and K. Wickwire. Univ. ofGeorgia and Oregon State Univ.A363 I 611.5 Effects of iron and/or zincdefi ciency on plasma mineral concentrations in rats. A. Konomiand K. Yokoi. Aichi Gakusen Univ. and Seitoku Univ., Japan.A364 II 611.6 The molar ratio of phytate:zinc isnegatively associated with birth weight: MOCEH study. Y.A.Lee, J-Y. Hwang, J. Hur, E-H. Ha, H. Park, M. Ha, Y. Kim, Y-C.Hong and N. Chang. Ewha Womans Univ., Dankook Univ. Col.of Med., Ulsan Univ. Hosp., Univ. of Ulsan and Seoul Natl. Univ.Col. of Med., South Korea.A365 I 611.7 Zn defi ciency induces calcifi cationby regulating apoptosis rather than osteogenesis in vascularsmooth muscle cells. E.H. Alcantara, M-Y. Shin, J.H. Beattieand I-S. Kwun. Andong Natl. Univ., South Korea and Univ. ofAberdeen.A366 II 611.8 Effects of bioactive dietary polyphenolson zinc transport across the intestinal Caco-2 cell monolayers.E-Y. Kim, T-K. Pai and O. Han. Penn State and Anyang Univ.,South Korea.A367 I 611.9 Measures of zinc status are weaklyassociated in healthy school children in Guatemala. V.Q.Bui, J.A. Marcinkevage, A.D. Stein, A.M. DiGirolamo, U.Ramakrishnan, R.C. Flores-Ayala, M. Ramirez-Zea, S.Villalpando and R. Martorell. Emory Univ., INCAP, GuatemalaCity and Natl. Inst. of Publ. Hlth., Cuernavaca, Mexico.SUNPathology612. APOPTOSIS AND AUTOPHAGYPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCCell and Tissue InjuryPresentation time: 11:30 AM-1:30 PMC<strong>10</strong>9 612.1 Subcutaneous tissue response of isogenicmice to a triantibiotic paste used as intracanal medication. G.Faria, M.S. S. Pereira, L.A. B. Silva, M. Tanomaru-Filho, J.M.Guerreiro-Tanomaru, M.C. Kuga and M.A. Rossi. UNESP,Araraquara, Brazil and Univ. of São Paulo, Ribeirão Preto.C1<strong>10</strong> 612.2 Ethanol-induced cell cycle arrest and apoptosisis mediated by sp1-dependent expression of p75NTR inneuroblastoma cells. H-J. Park, H. Do, E-H. Sohn, D-K. Rheeand S. Pyo. Sch. of Pharm., Sungkyunkwan Univ. and KangwonNatl. Univ., South Korea.C111 612.3 Differential apoptotic response of humanbreast cancer cells to allicin. K. Kim, D-K. Rhee and S. Pyo.Sungkyunkwan Univ. Sch. of Pharm., South Korea.C112 612.4 Reduced vasoconstriction to diadenosinepentaphosphate after ischemia-reperfusion in isolated ratkidney. A.L. Garcia-Villalon, M. Luis, N. Fernandez and G.Dieguez. Fac. of Med., Autonomous Univ. of Madrid.C113 612.5 Deltorphin-D and nerve growth factor inducecell protection in PC12 cells subjected to ischemia. P.R.Oeltgen, P.D. Bishop and S.A. Brown. VA Med. Ctr. and Univ.of Kentucky and ZymoGenetics Inc., Seattle.C114 612.6 Interferon-β enhances autophagy of vascularsmooth muscle cells. H-e. Byeon, D-k. Rhee and S. Pyo.Sungkyunkwan Univ. Sch. of Pharm., South Korea.175
PATHOLOGY613. HOST-MICROBIAL INTERACTIONS ANDINFLAMMATIONPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCMucosal PathobiologyCell and Tissue AdaptationsPresentation time: 11:30 AM-1:30 PMC115 613.1 Adhesion properties of commensal bacteriamediate ROS stimulation in intestinal epithelial cells. Y.M.Kwon, J.W. Mercante and A.S. Neish. Emory Univ. Sch. ofMed.C116 613.2 Intestinal microbiota modulate ROS-dependentepithelial cytoprotection through Nrf2. J.W. Mercante, R.M.Jones, L. Luo, K. Moberg and A.S. Neish. Emory Univ.C117 613.3 Mechanisms utilized by Francisella tularensisto invade hepatocytes. C.A. Thomas-Charles and M.B. Furie.Stony Brook Univ.C118 613.4 Evidence of a New World origin for caninedistemper. E.W. Uhl, C. Kelderhouse, J. Blick and R.J. Hogan.Univ. of Georgia and Georgia Col. and State Univ.C119 613.5 Taurine treatment reduces oxidative stress andpulmonary infl ammation by taurine, a murine asthma modelasthma induced by house dust and diesel particulate matter J.Kim, C. Cory, J.C. Bouchard, D.R. Beal, L. Vaickus and D.G.Remick. Boston Univ. Sch. of Med.614. INFLAMMATION AND IMMUNOPATHOLOGYPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCInflammationVascular <strong>Biology</strong>Presentation time: 11:30 AM-1:30 PMC120 614.1 Therapeutic effi cacy of L-kynurenine oncollagen-induced arthritis in mice. P.K. Javaregowda, Y. Hong,J-c. Jeon, J-H. Kim and Y. Hong. Inje Univ. and GyeongsangNatl. Univ., South Korea.C121 614.2 Skeletal muscle regeneration is dependentupon CCR2 expression on bone marrow-derived cells. J.T.Wells, L.M. McManus and P.K. Shireman. Univ. of Texas Hlth.Sci. Ctr. at San Antonio.C122 614.3 Mucosal infl ammation and risk of colorectaladenomas. J.M. Johnson, A. McCoy, F. Araujo-Perez, B.Jovov and T. Keku. Univ. of Maryland Eastern Shore and Univ.of North Carolina at Chapel Hill.C123 614.4 The role of Toll-like receptor 6 in collagenprocessing mechanism for intestinal fi brosis. J.A. Savage, D.P.Lebel and T.A. Reaves. Med. Univ. of South Carolina.C124 614.5 Effect of verapamil on experimental septiccardiomyopathy induced by cecal ligation and puncture. M.R.Celes, C.M. Prado, E.C. Campos, V. Blefari, L.M. Malvestio,F.Q. Cunha, H.B. Tanowitz and M.A. Rossi. Fac. of Med. ofRibeirão Preto, Univ. of São Paulo and Albert Einstein Col. ofMed., Yeshiva Univ.<strong>SUNDAY</strong>C125 614.6 Effect of tryptophan metabolites on collageninducedarthritis in mice. Y. Hong, P.K. Javaregowda, J-c.Jeon, J-H. Kim and Y. Hong. Inje Univ. and Gyeongsang Natl.Univ., South Korea.C126 614.7 Altered heat stroke infl ammatory responses inTNF double receptor knockout mice. L.R. Leon, M.D. Blahaand B.G. Helwig. U.S. Army Res. Inst. of Envrn. Med., Natick,MA.C127 614.8 CCR-3 ligands, CCL-5, 7, 11 and 26, areinduced in human retinal cells by infl ammatory cytokines:potential role in age-related macular degeneration C. Nagineni,V.K. Kommineni, N. Ganjbaksh, J.J. Hooks and B. Detrick.NEI, NIH and Johns Hopkins Univ.C128 614.9 Binge drinking rapidly triggers asthma-likepulmonary infl ammation in cockroach-allergen sensitized mice.J.C. Bouchard, J. Kim, D.R. Beal and D.G. Remick. BostonUniv. Sch. of Med.C129 614.<strong>10</strong> Effect of CCR4 antagonist on T cell-mediatedallergic airway infl ammation in mice. O. Kaminuma, A. Mori, T.Ohtomo, S. Sekizawa, D. Nagakubo, K. Hieshima, O. Yoshieand T. Hiroi. Tokyo Metro. Inst. of Med. Sci., Sagamihara Natl.Hosp., Kanagawa, Univ. of California, Davis and Kinki Univ.Sch. of Med., Japan.C130 614.11 Macrophage polarization in C57BL/6 and Ccl2 -/-/Cx3cr1 -/- mice. M. Liu, X. Cao, R. Villasmil, J. Tuo, D. Shenand C-C. Chan. NEI, NIH.C131 614.12 Wound macrophages express MHC class Iand II, express costimulatory molecules, and induce antigenspecific T cell proliferation J.M. Daley, J.R. Rotenberg, S.K.Brancato and J.E. Albina. Rhode Island Hosp. and AlpertMed. Sch. of Brown Univ.C132 614.13 The spleen as a potential source of IL-1 familycytokines following heat stroke. B.G. Helwig, M.D. Blaha, N.M.Majkut, L.D. Jones and L.R. Leon. U.S. Army Res. Inst. ofEnvrn. Med., Natick, MA.C133 614.14 Angiotensin converting enzyme overexpressionin mouse macrophages upregulates iNOS andmarkedly increases resistance to Listeria and MRSA. D.Okwan-Duodu, V. Datta, X. Shen, S. Fuchs, E. Bernstein, G.Liu and K. Bernstein. cedars-sinai medical center and EmoryUniv.C134 614.15 Identifi cation of cell types producing interferongammain the brain and periphery of simian immunodefi ciencyvirus-infected macaques. G. Guillaume, K. Witwer and C.Zink. Barry Univ., FL and Johns Hopkins Univ.C135 614.16 Substrate stiffness affects the response andphenotype of infl ammatory cells in vivo. N. Elisseou, E. Flores,D. Patel and J. Reichner. Brown Univ.C136 614.17 Macrophage ablation in CD11b-diphtheria toxinreceptor transgenic mice impairs skeletal muscle regeneration.H. Wang, L. Porter, Z.U. Sarwar, J.T. Wells, L.M. McManusand P.K. Shireman. Univ. of Texas Hlth. Sci. Ctr. at San Antonioand South Texas Veterans Hlth. Care Syst.C137 614.18 HLA-DQβ*0202 allele downregulates humoralantibody episodes of acute renal allograft rejection. V.K. R.Mannam, M. Santos, T. Green, M. Cowan, J. Goodin, R.E.Lewis, S.A. Bigler and J.M. Cruse. Univ. of Mississippi Med.Ctr.C138 614.19 HIV/AIDS knowledge and attitudes, amonguniversities’ students in Qatar A.A. Al-Thani, A. H.A. Al-Khenjiand A.A. Al-Saadi. Qatar Univ. and Hamad Med. Coop., Doha,Qatar.176
<strong>SUNDAY</strong>C139 614.20 Role of Th17 T-lymphocytes in advanced aidspatients with marked CD4 + T cell depletion. W.L. Singleterry,R.E. Lewis, S. Bigler and J.M. Cruse. Univ. of MississippiMed. Ctr.C140 614.21 Reversible myocardial dysfunction in HIV-Tattransgenic mouse. F. Chen, J.M. Hollander, W. Lewis, S. Xie,J. Hadfield and M.S. Finkel. West Virginia Univ., Emory Univ.and LA Johnson VA Med. Ctr., Clarksburg, WV.C141 614.22 Endocytosis of SARS coronavirus spikeprotein. A-D.N. Fowajuh and C. Machamer. Univ. of MarylandEastern Shore and Johns Hopkins Univ. Sch. of Med.C142 614.23 Comparison of the life cycle and the survivalstrategies of two sand fl y vectors of leishmanaisis. M.L. Artis,C. Meneses and D-E. Elnaiem. Univ. of Maryland EasternShore and NIAID, NIH, Rockville.C143 614.24 Cloning of Streptococcus pyogenes ackand pta genes, and purifi cation and characterization of thecorresponding recombinant proteins L.M. Rivera, S. Agarwaland V. Pancholi. Univ. of Puerto Rico-Mayaguez Campus andOhio State Univ.615. PATHOBIOLOGY OF AGINGPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCAgingMiscellaneous Organ PathobiologyPresentation time: 11:30 AM-1:30 PMC144 615.1 FoxO1 is involved in the antineoplastic effectof calorie restriction. I. Shimokawa, T. Komatsu, R. Mori, H.Hayashi and T. Chiba. Nagasaki Univ. Grad. Sch. of Biomed.Sci.C145 615.2 Antifi brotic effects of dehydroepiandrosteronein lung fi broblasts in vitro. C.M. Milla, M. Montaño, A. Lozano,R. Chavira, A. Pardo and M. Selman. Natl. Inst. of Resp. Dis.Ismael Cosío Villegas, Natl. Inst. of Med. Sci. and Nutr. SalvadorZubirán and Natl. Autonomous Univ. of Mexico, Mexico City.C146 615.3 Human astrocytes exhibit an increasedexpression of the cellular senescence biomarker p16INK4a inaged human brain and Alzheimer’s disease. R. Bhat, M. Moh, A.Bitto, C. Sell, C. Katsetos, F.U. Garcia, J.Q. Trojanowski andC. Torres. Drexel Univ. Col. of Med. and Univ. of Pennsylvania.C147 615.4 A role for p21-activated-kinase 2 in vascularsmooth muscle cell senescence. H-e. Byeon, D-k. Rhee andS. Pyo. Sungkyunkwan Univ. Sch. of Pharm., South Korea.C148 615.5 Acrylamide induces cellular senescence inmacrophage through ROS-MAPK signaling pathway. K. Kim,D-K. Rhee and S. Pyo. Sungkyunkwan Univ. Sch. of Pharm.,South Korea.C149 615.6 Inhibition of NF-κB enhances the characteristicsof aged muscle stem cells. J.D. Proto, A. Lu and J. Huard.Univ. of Pittsburgh Sch. of Med.616. VASCULAR BIOLOGY AND PATHOBIOLOGYPosterPATHOLOGYSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCVascular <strong>Biology</strong>Molecular PathologyPresentation time: 11:30 AM-1:30 PMC150 616.1 High density lipoprotein from patients withcoronary artery disease shows reduced binding and interactionwith human arterial endothelial cells. K.D. Navab, S. Safarpour,L. Vakili, M. Memarzadeh, J.B. Kim, O. Elboudwarej, S.Y.Hama, S. Vazirian and G. Hough. UCLA Geffen Sch. of Med.C151 616.2 Histopathological effects of ortaniquepeel polymethoxylated fl avones on organ structures ofhypercholesterolemic rats. C.O. Green, A.O. Wheatley, B.Hanchard, T. Gibson, D.A. McGrowder, L.L. Dilworth andH.N. Asemota. Univ. of West Indies, Jamaica.C152 616.3 Role of Toll-like receptor 4 in early intimal foamcell accumulation in apolipoprotein E-defi cient mice. D. Beasley,M. Higashimori, J.B. Tatro, K.J. Moore, M.E. Mendelsohnand J.B. Galper. Tufts Med. Ctr. and NYU Sch. of Med.C153 616.4 Protein kinase C delta (pkcδ) contributes toaneurysm development through JNK-mediated monocytechemoattractant protein 1 expression. C.A. Harberg, S.Morgan, D. Yamanouchi and B. Liu. Univ. of Wisconsin-Madison.C154 616.5 C-reactive protein polarizes humanmacrophages to an M1 phenotype. S. Devaraj and I. Jialal.Univ. of California, Davis Med. Ctr.C155 616.6 Statins synergize dexamethasone-inducedmacrophage aP2 expression — a dual glucocorticoid receptordependentmechanism. J. Han, W. Hu and X. Zhou. NankaiUniv., People’s Republic of China.C156 616.7 Loss of TDAG51 attenuates aorta smoothmuscle to osteoblast transdifferentiation and calcifi cation. I.Al-Bondokji, J.G. Dickhout, J. Krepinsky and R.C. Austin.McMaster Univ. and St. Joseph’s Healthcare, Hamilton,Canada.C157 616.8 The anti-infl ammatory cytokine IL-19 inducesHO-1 expression and decreases reactive oxygen species inhuman vascular smooth muscle cells. K. Gabunia, S. Kelemen,S. Ellison and M. Autieri. Temple Univ. Sch. of Med.C158 616.9 The anti-infl ammatory cytokine interleukin-19inhibits smooth muscle cell migration and activation ofcytoskeletal regulators of VSMC motility. K. Gabunia, S. Jain,R. England and M. Autieri. Temple Univ. Sch. of Med.C159 616.<strong>10</strong> Fine balance between HIF1 and HIF2 insmooth muscle is crucial for normal development and survival.L. Lei, D. Liu, W. Jiang, Y. Huang and F. Giordano. Yale Univ.C160 616.11 Compound C inhibits vascular smooth musclecell proliferation in an AMPK-independent manner. W. Durante,Y. Yu, B. Yates, A.R. Shebib, X-m. Liu, H. Wang and K.J.Peyton. Univ. of Missouri-Columbia and Temple Univ.C161 616.12 ALK1 and Endoglin regulation of EphrinB2and sprout formation: potential relevance to HHT. J-H. Kim, M.Peacock and C.C. W. Hughes. Univ. of California, Irvine.C162 616.13 PP2A-mediated dephosphorylation ofeNOS and Erk2: a new molecular mechanism of impairedangiogenesis in experimental duodenal ulcer. X. Deng, X.Xiong, B. Paunovic, Z. Sandor and S. Szabo. VA Long BeachHealthcare Syst.177SUN
<strong>SUNDAY</strong>C163 616.14 An antisense oligodeoxyribonucleotidedownregulating uPAR expression inhibits retinalneoangiogenesis both in vitro and in vivo. F. Di Gesualdo,M. Lulli, S. Bono, A. Lupia, E. Witort, M. Dal Monte and S.Capaccioli. Univ. of Florence, Phoenix Stem Cell Fndn. forHuman Life, Florence and Univ. of Pisa.C164 616.15 Cleaved high molecular weight kininogeninduces endothelial progenitor cell senescence in a ROSp38MAPK-p16INK4a signaling pathway and inhibits their vascularrepair capacity. J. Dai and Y. Wu. Soochow Univ., People’sRepublic of China and Temple Univ.C165 616.16 Protective effect of EUK-207 on irradiatiedhuman intestinal microvascular endothelial cells. M.F. Otterson,L. Nie, B.J. Link, J.L. Schmidt and P. Rafiee. Med. Col. ofWisconsin.C166 616.17 Matrix metalloproteinase (MMP)-1 and MMP-3 induced macrophage MMP-9: evidence for the role ofmicrosomal prostaglandin synthase-1. K. M.F. Khan, P. Kothari,B. Du, A.J. Dannenberg and D.J. Falcone. Weill Cornell Med.Col.C167 616.18 Hyaluronan fragmentation and MMP-12expression during pulmonary ischemia. L.M. Eldridge, A.Moldobaeva, C.G. Tankersley and E. Wagner. Sch. of Med.and Sch. of Publ. Hlth., Johns Hopkins Univ.C168 616.19 Proinfl ammatory phenotype in the 2-kidney,1-clip model of renovascular hypertension J. Grande, J. Cheng,G. Warner, C. Gray, B. Knudsen, K. Lien and J. Juskewitch.Mayo Clin.C169 616.20 Development of an in vitro model of the acutecoagulopathy of trauma. M.A. Meledeo, J.E. Campbell and P.D.Bowman. U.S. Army Inst. of Surg. Res., Fort Sam Houston.PATHOLOGY/PHARMACOLOGYC170 616.21 Immunologic differentiation of generic lowmolecular weight heparins. J.M. Walenga, M. Prechel, V.Escalante, W. Jeske and M. Bakhos. Loyola Univ. Chicago,Maywood.C171 616.22 Biological activities of two ultra-low molecularweight heparins, semuloparin and bemiparin, reveal that acommon potency standard is inappropriate W. Jeske, D.Hoppensteadt, A. Gray, J.M. Walenga, J. Cunanan, L. Myers,J. Fareed, A. Bayol, H. Rigal and C. Viskov. Loyola Univ. Med.Ctr. and Sanofi -Aventis, Vitry-sur-Seine.C172 616.23 α(1,3)-Fucosyltransferase-IV defi ciency contributesto a prothrombotic phenotype in mice H. Wang, J.Rose and J.W. Homeister. Univ. of North Carolina at ChapelHill.C173 616.24 Withdrawn.C174 616.25 Studies on the pathogenesis of systemiccapillary leak syndrome. R.A. Patel, Z. Xie and D. Kirk. NIAID,NIH.C175 616.26 Role of HMBG1/TLR4/IL-33 axis in cardiacmyocyte-fi broblast interaction in the development of diabeticcardiomyopathy. X. Xu, H. Xu, J. Zhang, R. Kao, C.M. Martinand T. Rui. Lawson Hlth. Res. Inst., Univ. of Western Ontarioand London Hlth. Sci. Ctr., Canada.C176 616.27 On the effects of vitamin K supplementation onhuman dermal fi broblasts. D. Quaglino, F. Boraldi, G. Annovi,D. Guerra, R. Tiozzo and L.J. Schurgers. Univ. of Modenaand Reggio Emilia, Italy and Univ. of Maastricht, Netherlands.C177 616.28 NAD-evoked responses in porcine isolatedmesenteric arteries. E. Alefishat, S. Alexander and V. Ralevic.Univ. of Nottingham.Pharmacology and <strong>Experimental</strong> Therapeutics617. BEHAVIORAL PHARMACOLOGY — GENERAL IPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:30 PM-2:45 PMC187 617.1 Time course, safety, and effi cacy of reversibleacetylcholinesterase inhibitors in cynomolgus macaques L.Hamilton, A. Bonvillain and T. Myers. U.S. Army Med. Res.Inst. of Chem. Def., Aberdeen Proving Ground, MD.C188 617.2 Neurobehavioral effects of lead and manganesein developmentally exposed rats: a comparative study betweenindividual and combined exposures. S. Betharia, M. Bohlkeand T. Maher. Massachusetts Col. of Pharm. and Hlth. Sci.C189 617.3 Morphine-induced motor stimulation andataxia: age-related differences in mice. W. Koek, C.P. Franceand M.A. Javors. Univ. of Texas Hlth. Sci. Ctr. at San Antonio.C190 617.4 Glial modulatory drugs, AV411 (ibudilast) andAV<strong>10</strong>13, blunt methamphetamine-induced locomotor activationand sensitization in mice S.E. Snider, S.A. Vunck, E.J. C. G.van den Oord, D.E. Adkins, J.L. McClay and P.M. Beardsley.Virginia Commonwealth Univ. Sch. of Pharm.C191 617.5 Cannabidiol prevents the development ofallodynia in paclitaxel-treated female C57BL6 mice. M.D.Ramirez, H. Neelakantan, E.A. Walker and S.J. Ward. Sch. ofSci. and Technol. and Sch. of Pharm., Temple Univ.C192 617.6 Cannabinoid-mediated diuresis in mice. G.R.Chopda, R. Sharma, G. Thakur, K. Vemuri, A. Makriyannisand C.A. Paronis. Northeastern Univ.C193 617.7 Effects of delta 9-tetrahydrocannabinol inassays of pain-stimulated and pain-depressed behavior in rats.A.J. Kwilasz and S. Negus. Virginia Commonwealth Univ.C194 617.8 Antinociceptive activity of carvacrol in formalin-,capsaicin- and glutamate-induced orofacial nociception inrodents L.J. Quintans, Jr., A.G. Guimarães, M.G. B. Oliveira,R.S. Barreto, S.C. H. Cavalcanti, A.A. S. Araújo, M.R. V.Santos, J.S. S. Quintans and L.R. Bonjardim. Fed. Univ. ofSergipe, Brazil.C195 617.9 Effects of the serotonin uptake inhibitorclomipramine in assays of pain-depressed and pain-stimulatedbehavior in rats. M.B. Rosenberg and S.S. Negus. VirginiaCommonwealth Univ.C196 617.<strong>10</strong> Remifentanil exposure produces hyperalgesiabut not morphine tolerance in rats. E.M. Jutkiewicz, Y. Sun,J.S. Schimmel and J.R. Traynor. Univ. of Michigan.C197 617.11 Role of beta-arrestin2 in the developmentof opiate-induced antinociceptive tolerance and physicaldependence. K. Raehal and L.M. Bohn. The Scripps Res.Inst.C198 617.12 Sex difference in the nociceptin/orphanin FQsystem in rat spinal cord following chronic morphine treatment.Y. Zhang and K.M. Standifer. Col. of Pharm., Univ. of OklahomaHlth. Sci. Ctr.178
PHARMACOLOGYC224 619.8 High cocaine locomotor responding rats havegreater hippocampal norepinephrine transporter function thanlow cocaine locomotor responding rats after acute cocaineexposure. T.L. Richards and N.R. Zahniser. Univ. of ColoradoDenver Sch. of Med.C225 619.9 Effects of monoamine releasers varying inselectivity to release dopamine/norepinephrine versus serotoninon choice between cocaine and food in rhesus monkeys. M.L.Banks, B.E. Blough and S.S. Negus. Virginia CommonwealthUniv. and Res. Triangle Inst., NC.C226 619.<strong>10</strong> Multiple cocaine unit doses are redundantwhen measuring the magnitude of effect of dopamine receptorantagonists on self-administration. A.B. Norman, M.R. Tabet,M.K. Norman and V.L. Tsibulsky. Univ. of Cincinnati.C227 619.11 Effect of injection duration on the acquisitionof cocaine self-administration in rats: the role of paired stimuli.C.W. Schindler, E.S. Cogan, E.B. Thorndike and L.V. Panlilio.NIDA, NIH, Baltimore.C228 619.12 Involvement of striatal and hippocampalsigma receptors in methamphetamine-induced maladaptation.A.M. Fennell, J. Swant, T. Ansah, J.S. Goodwin and H.Khoshbouei. Meharry Med. Col.C229 619.13 Adult and adolescent sensitivity to amphetaminefollowing early treatment with methotrexate in mice. A.M.Myers, E.B. Bisen-Hersh and E.A. Walker. Temple Univ.620. CHEMOTHERAPY — TARGET-BASEDDIAGNOSTICS AND THERAPEUTICSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:30 PM-2:45 PMC230 620.1 Repurposing old drugs to discover novelmultidrug resistance modulators for anti-cancer therapy. S.Arora, C. Garcia and A. Gonzalez. Kean Univ., NJ.C231 620.2 MS-based tissue and drug imaging tomonitor 4EBP1 phosphorylation status and drug-induceddephosphorylation in prostate cancer. N.J. Mastrandrea,C. Hattan, J. Gard, R. Nagle, T. Monks and S. Lau. Univ. ofArizona.C232 620.3 The comparative effectiveness of PARP1inhibitors alone or in combination against sporadic cancer. J.De Soto. Appalachain Col. of Pharm., VA.C233 620.4 Insulin resistance-associated hyperinsulinemiaactivates MEK/ERK signaling and promotes prostatic growth:reversal of effect with the intervention of PPARγ agonistpioglitazone. A. Vikram, P. Ramarao and G. Jena. Natl. Inst. ofPharmaceut. Educ. and Res., Mohali, India and Central Univ. ofPunjab.C234 620.5 The C-terminal transmembrane domain andloop region of Bcl-XS are important for its antiapoptotic activities.C.O. Eno, K.E. Olberding and C. Li. Univ. of Louisville.C235 620.6 Tyrosine phosphorylation of HSC70 mayregulate its methotrexate binding properties and multidrugresistance in L12<strong>10</strong> murine leukemia cell lines. T. Liu, P.P.Sheridan, A. Bhushan, J.C. K. Lai and C.K. Daniels. IdahoState Univ.C236 620.7 Post-formulation of peptide-nanostructuresfor metered control of NF-κB signaling. H. Pan, O. Ivashyna,B. Sinha, G. Lanza, L. Ratner, P.H. Schlesinger and S.A.Wickline. Washington Univ. Sch. of Med.C237 620.8 Impact of mitochondrial superoxide dismutaseon cytotoxic activity of resveratrol and its hydroxylatedanalogues in HeLa and C33A cancer cell lines. H. Piotrowska,J. Budna, M. Wierzchowski, U. Kazimierczak-Majchrzak, M.Kucinska and M. Murias. Poznan Univ. of Med. Sci., Poland.C238 620.9 Calpain and caspase orchestrated death signalto accomplish apoptosis induced by resveratrol and its novelanalog HST-1 in cancer cells. S.K. Bandyopadhyay, P. Guhaand A. Dey. Dr. BC Roy Post Grad. Inst. of Basic Med. Sci. andIPGME&R, Kolkata, Univ. of Maryland Sch. of Med. and Univ. ofFlorida Col. of Med.C239 620.<strong>10</strong> Cancer caveolin status: the dependence ofanesthetic exposure to postoperative cancer chemotherapy ininduction of cell death and survival. S. Okada, Y. Kawaraguchi,P.M. Patel, D.M. Roth and H.H. Patel. UCSD.C240 620.11 Biochemical analysis of a novel dual claudinbinder. Y. Kakamu, K. Matsushita, Y. Saito, A. Takahashi, K.Matsuhisa, A. Watari, M. Kondoh and K. Yagi. Osaka Univ.C241 620.12 A simple screening system for claudin bindersusing an scFv library derived from claudin-immunized mice. M.Kodaka, A. Takahashi, T. Yamaura, Y. Kakamu, K. Matsuhisa,K. Matsushita, A. Watari, M. Kondoh and K. Yagi. Grad. Sch.of Pharmaceut. Sci., Osaka Univ.C242 620.13 Phenol/hydroquinone reduces lymphocytecounts and produces quinol-thioether- and 4-hydroxy-2-nonenal-modifi ed proteins: implications for benzene-mediatedhematotoxicity. C.L. Kuhlman, D.R. Petersen, T.J. Monks andS.S. Lau. Univ. of Arizona and Univ. of Colorado Denver.C243 620.14 Lipid phosphate phosphatase-3 knockdownreduces glioblastoma tumor growth and metastasis bydampening β-catenin signaling. I. Chatterjee and K.K. Wary.Univ. of Illinois at Chicago.621. CHEMOTHERAPY — NATURAL PRODUCTSAND DERIVATIVESPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:30 PM-2:45 PM<strong>SUNDAY</strong>C244 621.1 Enhanced tumor cures after Foscanphotodynamic therapy combined with the ceramide analogLCL29: evidence from mouse squamous cell carcinomasfor sphingolipids as biomarkers of treatment response. D.Separovic, J. Bielawski, J. Pierce, S. Merchant, A. Tarca,G. Bhatti, B. Ogretmen and M. Korbelik. Wayne State Univ.,Med. Univ. of South Carolina and British Columbia CancerAgcy., Vancouver.C245 621.2 Antimitogenic and chemosensitizing activitiesof syringic acid in human colorectal cancer cells: potentialmolecular mechanisms of action. M.S. I. Abaza, M. Afzal, R.Al-Attiyah, R. Bhardwaj, G. Abbadi and M. Koyippally. Col.of Med., Kuwait Univ.C246 621.3 Antitumorous activity of alpha-bisabololagainst pancreatic cancer. T. Seki, T. Kokuryo, Y. Yokoyama,H. Suzuki, A. Nakagawa and M. Nagino. Nagoya Univ. Grad.Sch. of Med. and Univ. of Verona.180
<strong>SUNDAY</strong>C247 621.4 A synthetic polyphenol compound, 3-geranyl-2,4,6-trihydroxy-acetophenone, induces apoptosis andchemosensitization of adriamycin-resistant MCF-7 breastcancer cells Y-R. Kang, M-Y. Cho, S-Y. Park, Y.R. Lee, K.W.Kang, J-A. Kim and S.S. Han. Sch. of Pharm., Sch. of ChemEngin. and Technol. and Sch. of Textiles, Yeungnam Univ. andChosun Univ. Col. of Pharm., South Korea.C248 621.5 The effect of Momordica charantiaextract oncolorectal cancer precancerous lesions (aberrant crypt foci).T.S. Wynter, P. Singh, N. Williams and W. Mclaughlin. Univ.of West Indies, Jamaica.C249 621.6 The inhibitory effect of 5-hydroxyhexamethoxyflavone on human colon cancer cells. P. Qiu,H. Guan, J. Zheng, S. Guo, M. Song and H. Xiao. Univ. ofMassachusetts Amherst and Ocean Univ. of China.C250 621.7 Aciculatin, a C-glycosidic fl avonoid, inducesp53-dependent cell cycle arrest and apoptosis in HCT116colorectal cancer cells C-y. Lai, S-L. Pan, C-C. Chen and C-M.Teng. Col. of Med.. Natl. Taiwan Univ. and Hungkuang Univ.,Taiwan.C251 621.8 Anticancer activity of trilinolein from Panaxnotoginseng in human nonsmall cell lung cancer cells A549.P-Y. Chou. Natl. Chung Hsing Univ., Taiwan.622. CHEMOTHERAPY — NUCLEIC ACID-BASEDAPPROACHES TO THERAPYPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:30 PM-2:45 PMC252 622.1 Identifi cation of novel chemosensitivity nodesfor vinblastine using siRNA synthetic lethal screens. C.A.Kitchens, P.R. McDonald, T.Y. Shun, I.F. Pollack and J.S.Lazo. Univ. of Pittsburgh.C253 622.2 The effi ciency of Nek2 siRNA for livermetastasis of pancreatic cancer. T. Kokuryo, Y. Yokoyama, T.Seki, A. Nakagawa and M. Nagino. Nagoya Univ. Grad. Sch.of Med.C254 622.3 microRNA signaling in stem-like ABCG2 +retinoblastoma cells. Y. Pan, G.M. Seigel, Z. Hu and A. Yu.SUNY at Buffalo, Amherst.C255 622.4 Aptamer-mediated complement system killingof MCF-7 and MEAR cancer cells. J.R. Stecker, J.G. Brunoand J.R. Koke. Texas State Univ., San Marcos and OTCBiotechnol. LLC, San Antonio.C256 622.5 Internalization of the DNA TLS-11a aptamer inMEAR liver hepatoma cells. J.R. Stecker, J.G. Bruno and J.R.Koke. Texas State Univ., San Marcos and OTC Biotech. LLC,San Antonio.623. DRUG DISCOVERY, DEVELOPMENT ANDREGULATORY AFFAIRSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:30 PM-2:45 PMPHARMACOLOGYC257 623.1 Marine pharmacology and the 2011pharmaceuticals pipeline. A.M. Mayer and K.B. Glaser.Midwestern Univ., IL and Abbott Labs.C258 623.2 Current drug scheduling reviews reported bythe DEA. M.D. Walker, C. Prioleau, S. Ghozland, T. Boos, S.Tella and C. Sannerud. Drug Enforcement Admin., Arlington,VA.C259 623.3 Preparation of a dual claudin binder using afragment of Clostridium perfringens enterotoxin. A. Takahashi,Y. Saito, K. Matsuhisa, Y. Kakamu, M. Kodaka, A. Watari, M.Kondoh and K. Yagi. Grad. Sch. of Pharmaceut. Sci., OsakaUniv.C260 623.4 A substrate-based approach to convertserpinB1 into a specifi c inhibitor of proteinase 3, the Wegenergranulomatosis autoantigen B. Korkmaz, G. Jégot, C.Derache, E. Remold-O’Donnell, C. Kellenberger and F.Gauthier. INSERM, Tours and CNRS Orléans and Marseille.C261 623.5 Pharmacological assessment of a hialuronanjelly to wound healing. biochemical evaluation of dermalreconstitution. L. Oruña and G.M. Coto. State Quality Cntrl.Drug Ctr. and Placental Histotherapy Ctr., Havanna.C262 623.6 Bioassay-guided evaluation of wound healingeffect of atranorin in rodents. R.S. Barreto, B. E.S. Araújo, J.S.Siqueira, J.M. DeSantana, A. Araújo, A.S. Barreto, M.R. V.Santos, R. L.C. Albuquerque, Jr. and L.J. Quintans, Jr. Fed.Univ. of Sergipe and Tiradentes Univ., Brazil.C263 623.7 Comparisons of intranasal delivery offl uorescent probe Cy5.5 and i.v. injection of Cy5.5. H. Chen,C. Sheng, N. Liu, B. Wang, J. Peng, W. Xia and W. Ying.Shanghai Jiao Tong Univ., People’s Republic of China.C264 623.8 Progress toward developing an intranasal genetherapy approach for CNS disorders. B. Harmon, M. Cooper,M. Migliore, R. Loring and B. Waszczak. Northeastern Univ.,Copernicus Therapeut. Inc., Cleveland and Massachusetts Col.of Pharm. and Hlth. Sci.C265 623.9 Generation and in vitro characterization oftherapeutic anti-methamphetamine antibody-nanoparticleconjugates. N.G. Nanaware, G.A. Gonzalez III and E.C.Peterson. Univ. of Arkansas for Med. Sci.C266 623.<strong>10</strong> High throughput identifi cation of mitochondrialtoxicophores. R.E. Trager, L. Wills, C. Lindsey, G. Beeson,C. Beeson, R. Schnellmann and Y. Peterson. Med. Univ. ofSouth Carolina and Ralph H. Johnson VA Med. Ctr.C267 623.11 Developing novel fatty acid amide hydrolaseinhibitors for the treatment of pain. J. Faloon, C. Ezzili, D.Giuvelis, J.J. Lowery, N. McGlinchey, D. Boger and E.J.Bilsky. Univ. of New England and The Scripps Res. Inst.C268 623.12 The fl uid from the immature fl ower bud ofSpathodea campanulata reduces intraocular pressure in dogs.C.L. S. Golding, M.E. West, M-L.G. McKoy and E.A. Thomas.Univ. of West Indies, Jamaica.SUN181
PHARMACOLOGY624. NUCLEAR HORMONE RECEPTOR SIGNALINGPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:30 PM-2:45 PMC269 624.1 Estrogen receptor antagonist fulvestrant (ICI182,780) inhibits the anti-infl ammatory effect of glucocorticoidsE. Esposito, S. Bruscoli, E. Mazzon, E. Vegeto, A. Maggi andS. Cuzzocrea. Sch. of Med., Univ. of Messina, Univ. of Perugia,IRCCS Ctr. Neurolesi Bonino Pulejo, Messina and Univ. ofMilan.C270 624.2 Study of hormonal receptors in dystrophicmice muscles. E.Y. Fukuda, R.D. Chiovatto, D. Feder, M.L. G.Pereira, I.R. B. Godoy, C.S. Silva, D.N. Silvestre, V.B. Palou,A.A. Carvalho, R.A. Santos, M.H. de Carvalho, C.Z. Nassisand C. Carrico. ABC Sch. of Med., Brazil, São Paulo Univ. andASPET, Bethesda.C271 624.3 Parturition alters estrogen signaling inmicrovascular arteries: impaired nNOS. C. Royal, R. Walker,H. Ma and R. White. Med. Col. of Georgia.C272 624.4 Toxicometabolomics of heated vegetable oilsinduced adverse effects. C. Chen, D. Schwinkendorf, D. Yaoand A.S. Csallany. Univ. of Minnesota, St. Paul.C273 624.5 Role of B1 adrenergic receptor in cardiacresponsiveness during thyrotoxicosis. B.M. L. Bocco, R.J.Nassif and M.O. Ribeiro. Mackenzie Presbyterian Univ.,Brazil.C274 624.6 Thyoid hormone receptor alpha activation playsan important role inBAT adaptative thermogenesis. L.X. S.Farah, R.J. Nassif, T. Scanlan and M.O. Ribeiro. MackenziePresbyterian Univ., Brazil and Sch. of Med., Oregon Hlth. & Sci.Univ.625. CELL SURFACE RECEPTORSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:30 PM-2:45 PMC275 625.1 The role of the Na + /H + exchange regulatoryfactor (NHERF) in EGF receptor (EGRF) transactivation andEGF-induced extracellular signal regulated kinase in NHERFdeficient and -replete OKH clones. M.M. Miller and J.A. Cole.Univ. of Memphis.C276 625.2 Epidermal growth factor,2,3,7,8-tetrachlorodibenzo-p-dioxin and calcium (Ca 2+ ) induceloss of whole cell [ 125 ]-EGF binding in a temporally distinctmanner. C.M. Campion, S. Bodreddigari, C.H. Sutter, T.R.Sutter and J.A. Cole. Univ. of Memphis and W. Harry FeinstoneCtr. for Genomic Res.C277 625.3 SR-A ligand and M-CSF dynamically regulateSR-A expression and function in primary macrophages via p38MAPK activation. D. Nikolic, L. Calderon, L. Du and S. Post.Univ. of Arkansas for Med. Sci., Univ. of Kentucky and Univ. ofTexas Southwestern Med. Ctr.626. GPCR — LIGAND BINDING PHARMACOLOGYPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:30 PM-2:45 PM7:30 AMC278 626.1 Photolabeling, purifi cation andidentifi cation of the non-AT 1, non-AT 2angiotensin binding siteN.J. Wangler, E. Escher, F.K. Hagen, R.C. Speth and V.T.Karamyan. Sch. of Pharm., Texas Tech Univ. Hlth. Sci. Ctr.,Amarillo, Univ. of Sherbrooke, Canada, Univ. of Rochester Med.Ctr. and Col. of Pharm., Nova Southeastern Univ., FL.7:31 AMC279 626.2 6’-Guanidinonaltrindole is a potentand functionally unique kappa opioid agonist that displays biasagainst beta-arrestin recruitment and receptor internalization.J.M. Streicher, C.E. Groer, T. Munro, C. Beguin, B.M. Cohenand L.M. Bohn. The Scripps Res. Inst., Jupiter, FL, McLeanHosp., Belmont, MA and Harvard Med. Sch.7:32 AMC280 626.3 Dynorphin A is a competitive, partialagonist at the bradykinin receptors J. Lai, D.R. Rankin, A.T.Cai, Y-S. Lee, V.J. Hruby and F. Porreca. Univ. of Arizona.7:33 AMC281 626.4 Evaluation of a novel radioligandfor the labeling of β 3-adrenoceptors, [ 3 H]-L 748,337 J-P. vanWieringen, M.B. Michel-Reher and M.C. Michel. Acad. Med.Ctr., Amsterdam.7:34 AMC282 626.5 Is nebivolol, which is classifi ed as aβ1-adrenegic receptor antagonist, a biased agonist?. R. Gul,C.E. Erickson, J.R. Sowers, L. Pulakat and B.T. Andresen.Univ. of Missouri-Columbia and Harry S Truman VA Med. Ctr.7:37 AMC283 626.6 Characterization of fl uorescentGPCR-ligand dendrimer conjugates in binding to the A 3adenosine receptors. R. Balasubramanian, D.K. Tosh, J.R.Lloyd, Z-G. Gao and K.A. Jacobson. NIDDK, NIH.7:35 AMC284 626.7 Molecular bar coding and cell specifi csignaling with multivalent tethered ligands. C. Weber, J. Vagner,V. Hruby, R. Gillies and R. Lynch. Univ. of Arizona and Moffi ttCancer Ctr., Tampa.7:36 AMC285 626.8 Pharmacological characterization ofhuman, monkey and rat MT1 and MT2 receptors L.L. Lopresti-Morrow, R. Beveridge, P.A. Carpino, K.O. Cameron, E.Chorabik, P. Lingala, P.M. Loria, C. Petras, L. Rogers andJ.E. Chin. Pfi zer Inc.627. GPCR — DIMERIZATIONPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:30 PM-2:45 PM<strong>SUNDAY</strong>C286 627.1 Pick your partner carefully: GPCRheteromerization selectively alters agonist potency. H. Yano, E.Urizar and J.A. Javitch. Columbia Univ.C287 627.2 Identifi cation of an intracellular surface involvedin M3 muscarinic receptor dimerization. J. Hu, Y. Zhou, D. Thor,Y. Wang, S.M. McMillin, S. Costanzi and J. Wess. NIDDK,NIH.C288 627.3 Multiple transmembrane segments are involvedin M3 muscarinic receptor dimerization/oligomerization. S.M.McMillin, M. Heusel, S. Costanzi and J. Wess. NIDDK, NIH.182
<strong>SUNDAY</strong>C289 627.4 Regulation of DOR and DOR-KOR heteromersignaling in peripheral sensory neurons. B.A. McGuire, T.A.Sanchez, Y.M. Silva, M.P. Rowan, W.P. Clarke and K.A. Berg.Univ. of Texas Hlth. Sci. Ctr. at San Antonio.628. GPCR — DESENSITIZATION/TRAFFICKINGPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:30 PM-2:45 PMC290 628.1 Cell type-dependent internalization of the ADPactivatedP2Y1 receptor. A-D. Qi, D.M. Glast, T.K. Harden andR.A. Nicholas. Univ. of North Carolina at Chapel Hill.C291 628.2 Peptide inhibitors of GRK phosphorylation ofrhodopsin. F. Baameur, R.A. Hammitt, R.B. Clark and J.S.McMurray. Univ. of Texas Hlth. Sci. Ctr. at Houston and MDAnderson Cancer Ctr.C292 628.3 Retromer terminates the generation ofcAMP by internalized G protein-coupled PTH receptors. T.N.Feinstein and J-P. Vilardaga. Univ. of Pittsburgh Sch. of Med.and Massachusetts Gen. Hosp. and Harvard Med. Sch.C293 628.4 Novel insights into the role of arrestin-2 inendosomal sorting of CXCR4. R. Malik and A. Marchese.Loyola Univ. Chicago, Maywood.C294 628.5 Phosphorylated serine and threonine residuesof PAR2 C-terminus direct β-arrestin 1/2 recruitment andbinding. K. Pal and K. DeFea. Univ. of California, Riverside.C295 628.6 SAP97 controls β1-adrenergic receptortraffi cking in a PDZ-dependent manner. M.M. Nooh and S.W.Bahouth. Univ. of Tennessee Hlth. Sci. Ctr., Memphis and Fac.of Pharm., Cairo Univ.C296 628.7 Rab8 interacts with distinct motifs in α2B- andβ2-adrenergic receptors and differentially modulates theirtransport. C. Dong, L. Yang, X. Zhang, H. Gu, H. Xia, M.L. Lam,W.C. Claycomb and G. Wu. LSU Hlth. Sci. Ctr., New Orleans.C297 628.8 The human prostacyclin receptorcontains a novel Rab11 binding domain that is regulated bypalmitoylation. E.C. Turner, E.P. Mulvaney, H.M. Reid and B.T.Kinsella. University Col. Dublin Sch. of Biomolec. & Biomed.Sci.C298 628.9 N-linked glycosylation of protease-activatedreceptor-1 regulates receptor activation and internalization.A.G. Soto and J. Trejo. UCSD.C299 628.<strong>10</strong> Palmitoylation of protease-activated receptor-1:regulation of receptor ubiquitination and intracellular traffi cking.I. Canto and J. Trejo. UCSD Sch. of Med.C300 628.11 Modulation of α- 2Cadrenergic receptorintracellular traffi cking by arginine-based motifs. C. Filipeanu.LSU Hlth. Sci. Ctr., New Orleans.C301 628.12 Comparison of the effects of proteasomalinhibitors and lysosomal inhibitors on the carbachol-induceddownregulation of M 1-M 4receptors. A. Thangaraju and G.W.Sawyer. Oklahoma State Univ. Ctr. for Hlth. Sci.C302 628.13 Ipsen 5i is a novel melanocortin-4 receptorpharmacological chaperone. Y-X. Tao. Auburn Univ.629. GPCR — ACTIVATION MECHANISMSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:30 PM-2:45 PMC303 629.1 Agonist dependent tolerance property ofD3 dopamine receptor: a role for second extracellular loopresidues. E.V. Kuzhikandathil, S. Gil-Mast and S. Kortagere.UMDNJ-New Jersey Med. Sch. and Drexel Univ. Col. of Med.C304 629.2 Analysis of dopamine D2 receptor mutantsdefi cient in arrestin binding using bioluminescence resonanceenergy transfer. C.C. Clayton and K.A. Neve. Oregon Hlth. &Sci. Univ. and Portland VA Med. Ctr.C305 629.3 Adhesion via the N-terminus shapes themasking and traffi c of the neuropeptide Y Y2 receptor. S.L.Parker and M.S. Parker. Univ. of Tennessee Hlth. Sci. Ctr. andUniv. of Memphis.C306 629.4 Regulation and signaling of the orphan GPCRbrain angiogenesis inhibitor-1. J.R. Stephenson, K.J. Paavolaand R.A. Hall. Emory Univ.C307 629.5 The GPR56 N-terminus controls receptorsignaling activity. K.J. Paavola, J.R. Stephenson and R.A.Hall. Emory Univ.C308 629.6 Comparison of the activation kinetics of the M3-ACh-receptor and a constitutive active mutant receptor in livingcells. C. Hoffmann, S. Nuber, U. Zabel, N. Ziegler, P. Hein, M.Lohse and M. Buenemann. Univ. of Wuerzburg, Germany.C309 629.7 Agonist-dependent oxidation of the β2adrenergic receptor: selective cysteine sulfenic acid formationas detected by a modifi ed biotin-switch assay. R.N. Burns andN.H. Moniri. Col. of Pharm. and Hlth. Sci., Mercer Univ.630. ENDOTHELIAL CELLS — OXIDATIVE STRESSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:30 PM-2:45 PMPHARMACOLOGYC3<strong>10</strong> 630.1 The protective effects of Angelica sinesisextracts against tert-butyl hydroperoxide induced oxidativestress and apoptosi in rat vascular endothelial cells. Y-C. Yeh,J-C. Lo, L-C. Wang and H-C. Ou. Grad. Inst. of Nat. HealingSci., Chiayi Cty., Ctr. of Cardiovasc., Taichung and Grad. Inst.of Rehabil. Sci., Taichung, Taiwan.C311 630.2 Lysosomal fusion mediated super oxideproduction in hyperglycaemia-induced endothelial dysfunction.J-X. Bao, H. Chang, Y-G. Bai, J-W. Yu, Z-B. Yu and J. Ma.Fourth Military Med. Univ., People’s Republic of China.C312 630.3 Ergothioneine shows protective effect onendothelial cells in oxidative stress. A.S. M. Sit, E.Y. W. Ho,R.W. S. Li, R.Y. K. Man, Y.W. Kwan, P.M. Vanhoutte and G.P.H. Leung. Univ. of Hong Kong and Chinese Univ. of HongKong.C313 630.4 Inhibition of oxidative radical productionprevents diabetes-induced vascular dysfunction throughdecreased arginase activation. L. Yao, S. Chandra, H.A.Toque, Z. Xu, R.B. Caldwell and R.W. Caldwell. Med. Col. ofGeorgia.SUN183
<strong>SUNDAY</strong>C314 630.5 Glucosamine protects against TNFα-inducedendothelial dysfunction in cultured rat aortic rings. R. Hilgersand S. Oparil. Univ. of Alabama at Birmingham.C315 630.6 Upregulation of heme oxygenase-1 impairsendothelium-dependent contractions. Z. Li and P.M. Vanhoutte.Univ. of Hong Kong.631. ENDOTHELIAL CELLS — REGULATIONPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:30 PM-2:45 PMC316 631.1 Prenatal hypoxia programs vascularendothelin-1 activity in adult offspring. S. Bourque and S.Davidge. Univ. of Alberta.C317 631.2 Dual ECE/NEP inhibition and ETA/B receptorantagonists: two ways of inhibiting endogenous ET-1 effectsin resistance arteries. P. Lemkens, J. Nelissen, M.J. P. M. T.Meens, J.G. P. Bost, B.J. A. Janssen, P.M. H. Schiffers andJ.G. R. De Mey. Maastricht Univ., Netherlands.C318 631.3 Characterization of gender related differencesin vascular reactivity of mesenteric veins and arteries toendothelin-1 in gonadally intact and nurtured rats. A.S. Al-Najeer and R. Johnson. Univ. of Guelph, Canada.PHARMACOLOGY/PHYSIOLOGYC319 631.4 Gender-specifi c relaxation effects of luteolin inrat mesenteric arteries. Y. Zhang, S.W. S. Leung and R.Y. K.Man. Univ. of Hong Kong.C320 631.5 Gender differences in mesenteric endothelialfunction of streptozotocin-induced diabetic rats: role ofendothelium-derived relaxing factors. R. Zhang, L. Andersonand R. Rahimian. Sch. of Pharm. & Hlth. Sci., Univ. of Pacifi c,Stockton and Sch. of Dent., Univ. of Pacifi c, San Francisco.C321 631.6 Endothelium-derived hyperpolarizing factordependentrelaxation diminishes with age in murine saphenousarteries. R. Chennupati, E. Koehler, W. Lamers, B. Janssenand J. De Mey. Maastricht Univ., Netherlands.C322 631.7 Activation of nicotinic receptors contributes toacetylcholine-induced endothelium-denpendent relaxations inrat aorta. Q. Zou and P.M. Vanhoutte. Univ. of Hong Kong.C323 631.8 Vascular protective action of GLP-1 in vivo. R.Scalia, D. Feather and G. Mishra. Sch. of Med., Temple Univ.C324 631.9 A non-GPCR dependent role for P-Rex1 inendothelial cells. R.P. Naikawadi, N. Cheng, D. Wu and R. Ye.Univ. of Illinois at Chicago and Yale Univ. Sch. of Med.C325 631.<strong>10</strong> Paracrine dysfunction in diabetic endothelialprogenitor cells. Y.P. R. Jarajapu, M.K. Raizada, S.H.Bartelmez and M.B. Grant. Univ. of Florida and BetaStemTherapeut. Inc., San Francisco.Physiology632. LYMPHATICS AND VENULAR FUNCTIONPoster(Sponsored by: The Microcirculatory Society)SUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-3:00 PMD1 632.1 Rho kinase enhances tone in contractilelymphatics. K.M. Kurtz, F. Souza-Smith and J.W. Breslin.LSU Hlth. and Sci. Ctr., New Orleans.D2 632.2 Rat mesenteric lymphatics undergo remodelingand have altered contractility and calcium sensitivity in amodel of metabolic syndrome. S.D. Zawieja, W. Wang, Z.Nepiyushchikh, X. Wu, D.C. Zawieja and M. Muthuchamy.Texas A&M Hlth. Sci. Ctr. Col. of Med.D3 632.3 Short-term functional adaptation of bovinemesenteric lymphatic vessels to partial occlusion. T.L. Nguyen,R.M. Dongaonkar, J. Hardy, R.H. Stewart and E. Wilson.Texas A&M Univ. and Texas A&M Hlth. Sci. Ctr.D4 632.4 Acute alcohol intoxication increases themagnitude of phasic Ca 2+ transients in rat mesenteric collectinglymphatics. F.M. Souza, K. Kurtz, P. Molina and J. Breslin.LSU Hlth. Sci. Ctr., New Orleans.D5 632.5 A resident population of APC within themuscularized vessel walls of the rat lymphatic network. W.Wang and D.C. Zawieja. Texas A&M Hlth. Sci. Ctr., Temple.D6 632.6 Contractility and fl ow in aged mesentericlymphatic vessels. A.A. Gashev, T.J. Akl, T. Nagai and G.L.Cote. Texas A&M Hlth. Sci. Ctr., Col. of Med. and Texas A&MUniv.D7 632.7 Rapid myogenic constriction of isolatedcollecting lymphatic vessels to abrupt increases in outputpressure. J.H. Wolpers and M.J. Davis. Univ. of Missouri Sch.of Med.D8 632.8 Heterogeneous production and infl uencesof NO along the lymphatic endothelium. H.G. Bohlen, O.Y.Gasheva and D.C. Zawieja. Indiana Univ. Med. Sch. and TexasA&M Hlth. Sci. Ctr. Col. of Med., Temple.D9 632.9 Nitric oxide-dependent cellular signaling incultured lymphatic smooth muscle cells. M.N. Uddin, O.Y.Gasheva and D.C. Zawieja. Texas A&M Hlth. Sci. Ctr. Col. ofMed., Temple.D<strong>10</strong> 632.<strong>10</strong> Adenylate cyclase: role in regulation ofcontractility of mesenteric lymphatic vessels in adult and agedrats. T. Nagai and A.A. Gashev. Texas A&M Hlth. Sci. Ctr. Col.of Med.D11 632.11 Class III β-tubulin identifi cation of angiogenicpericytes and lymphatic sprouts during microvascularremodeling. P.C. Stapor and W.L. Murfee. Tulane Univ.184
<strong>SUNDAY</strong>633. PERMEABILITY/FLUID AND SOLUTEEXCHANGE/GLYCOCALYXPoster(Sponsored by: The Microcirculatory Society)SUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-3:00 PMD12 633.1 microRNA-147b and -650 modulate ADAM15expression in the regulation of endothelial cell permeability. M.Guo, M.H. Wu, C. Sun and S.Y. Yuan. Univ. of California DavisSch. of Med.D13 633.2 Epac1/Rap1 activation ameliorates alcoholinducedbarrier dysfunction. T.M. Doggett and J.W. Breslin.LSU Hlth. Sci. Ctr., New Orleans.D14 633.3 Inhibiting the production of hyaluronan disruptsthe endothelial glycocalyx and impairs arteriogenesis. D. Potter,B. van den Berg and H. Vink. Maastricht Univ., Netherlands.D15 633.4 Caveolin-1 scaffolding domain inducesleukocyte adhesion without increasing permeability in intact ratmesenteric venules. S. Xu, X. Zhou, D. Yuan, Y. Xu and P. He.West Virginia Univ. Sch. of Med.D16 633.5 Streptozotocin-induced diabetes enhancesmicrovessel permeability responses to acutely appliedinfl ammatory mediator in rat mesenteric venules. D. Yuan, X.Zhou, S. Xu and P. He. West Virginia Univ. Sch. of Med.D17 633.6 Assessment of transcapillary transport offl uorescently labeled insulin in mouse cremaster muscle. J.VanTeeffelen, M. Dane, T. Rademakers, M. van Zandvoort,H. Vink and B. Eskens. Maastricht Univ., Netherlands.D18 633.7 Effect of malignant mammary MDA-MB-231cell adhesion on microvessel permeability. B.M. Fu, B. Cai andM. Zeng. City Col. of New York, CUNY.D19 633.8 Small batch preparation of dye-labeled albuminfor assessment of in vivo microvascular barrier function. S.BIngaman and V.H. Huxley. Univ. of Missouri-Columbia.D20 633.9 Phosphodiesterase 4 inhibitor rolipramattenuates vascular permeability during volume expansion.Y-c. Lin, J.F. Clark, R.H. Adamson and F-R.E. Curry. Univ. ofCalifornia, Davis.D21 633.<strong>10</strong> Inhibitory effect of sphingosine-1-phosphate onmicrovessel acute permeability response is rapidly reversible.R.H. Adamson, A. Altangerel, R.K. Sarai, J.F. Clark andF-R.E. Curry. Univ. of California, Davis.D22 633.11 Blood-brain barrier leakage and cerebraledema in an impact-acceleration model of traumatic braininjury in mice. R.R. Rigor, C.D. Pivetti, M.H. Wu and S.Y. Yuan.Univ. of California Davis Sch. of Med.634. TISSUE-MICROVESSEL INTERACTIONS/EXTRACELLULAR MATRIXPoster(Sponsored by: The Microcirculatory Society)SUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-3:00 PMD23 634.1 Continuous interstitial fl uid pressure-volume(compliance) measurement. R.M. Dongaonkar, J.C. Vo, C.M.Quick, R.H. Stewart and G.A. Laine. Texas A&M Univ.D24 634.2 Attenuation in acetylcholine, nitroprusside, andphenylephrine-dependent change in blood fl ow contributes tobone microvascular remodeling in hyperhomocysteinemia A.B.Dankowski. Univ. of Louisville.D25 634.3 Integrin beta4 signaling on mammary tumorcell adhesion to brain microvascular endothelium. B.M. Fu, J.Fan, B. Cai, M. Zeng, Y. Hao and F.G. Giancotti. City Col. ofNew York, CUNY and Mem. Sloan-Kettering Cancer Ctr.D26 634.4 Regional heterogeneity in the mechanicalenvironment of the arteriolar wall due to differences inadventitial matrix. A. Stupica, P.S. Clifford, S.R. Ella, Z.Nourian, Y. Yang, K.A. Dora, L. Martinez-Lemus, M.J. Davis,G.A. Meininger and M.A. Hill. Univ. of Missouri-Columbia,Med. Col. of Wisconsin and Univ. of Oxford.D27 634.5 Arteriolar myogenic response during clampingof intracellular vascular smooth muscle calcium using BAPTA.Z. Sun, Z. Li and G.A. Meininger. Univ. of Missouri-Columbia.635. MICROVASCULAR DEVELOPMENT AND AGINGPoster(Sponsored by: The Microcirculatory Society)SUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-3:00 PMPHYSIOLOGYD28 635.1 Shear stress-dependent modulation of mTORsignaling in the endothelium of aged vessels. D. Sun, A. Huangand G. Kaley. New York Med. Col.D29 635.2 Functional availability of vascular angiotensintype 1 receptors is altered by aging. Z. Vamos, P. Cseplo, H.Koller, P. Degrell, J. Hamar, P. Toth and A. Koller. Med. Sch.,Univ. of Pecs, Hungary and New York Med. Col.D30 635.3 Microarray analysis of strain and age-specifi cgene expression associated with age-dependent intimalthickening of rat thoracic aorta. G. Gruionu and S.J. Miller.Indiana Univ. Sch. of Med. and Indiana Univ.D31 635.4 Microarray analysis of strain and age-specifi cgene expression associated with strain-dependent impairmentof fl ow-induced collateralization in rat mesenteric arteries. G.Gruionu and S.J. Miller. Indiana Univ. Sch. of Med.D32 635.5 VDAC is a conduit for ATP released from humanred blood cells in response to prostacyclin (PGI2) receptor(IPR) activation. M. Sridharan, M. Krantic, J. Richards, K.Dietrich, E. Bowles, A.H. Stephenson, M.L. Ellsworth andR.S. Sprague. Saint Louis Univ.SUN185
PHYSIOLOGYD33 635.6 The 400 year old heart: association of increasedresistance to oxidative stress with extreme longevity. Z. Ungvari,I. Ridgway, E. Phillips, D. Sosnowska, W.E. Sonntag, S.N.Austad and A. Csiszar. Univ. of Oklahoma Hlth. Sci. Ctr., Sch.of Ocean Sci., Bangor Univ., U.K., Christian Albrechts Univ.Kiel and Univ. of Texas Hlth. Sci. Ctr. at San Antonio.D34 635.7 Effects of aging on purinergic vasoconstrictionin skeletal muscle arterioles. B.J. Behnke, R.T. Davis III, X. Ma,D.J. McCullough, J.M. Dominguez II and M.D. Delp. Univ. ofFlorida.D35 635.8 Juvenile growth reduces the infl uence ofepithelial sodium channels on arteriolar tone. L. Kang, S.Masilamani, T. Nurkiewicz and M. Boegehold. West VirginiaUniv. and Virginia Commonwealth Univ. Med. Ctr.636. ANGIOGENESIS/REMODELING/INJURY ANDREPAIRPoster(Sponsored by: The Microcirculatory Society)SUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-3:00 PMD36 636.1 Homocysteine activates mGluR5- and PKCdependentCx43 phosphorylation at S368 and impairsproliferation of brain microvascular endothelial cells. C-H.Chen, R.S. Beard and S.E. Bearden. Idaho State Univ.D37 636.2 Arteriolar and venular remodeling aredifferentially regulated by bone marrow-derived cell-specifi cCX3CR1 and CCR2 expression. J. Meisner, M.M. Nickersonand R.J. Price. Univ. of Virginia.D38 636.3 Intravascular pillars and microvascular pruningin the extraembryonic vessels of chick embryos. G.S. Lee, N.Filipovic, Z. Milosevic, M. Lin, B.C. Gibney, D.C. Simpson,M.A. Konerding, A. Tsuda and S.J. Mentzer. Brigham andWomen’s Hosp., Harvard Med. Sch., Harvard Sch. of Publ.Hlth., Univ. of Kragujevac, Serbia and Johannes GutenbergUniv. Mainz.D39 636.4 The structure of giraffe resistance arteriesfrom muscular beds correlates with the transmural pressure.C. Aalkjaer, J. Andresen, T. Broegger, E. Broendum, N.Skovgaard and N. Telinius. Aarhus Univ., Denmark.D40 636.5 A potential role for angiotensin II in skeletalmuscle overload-induced angiogenesis. J.L. Doyle and T.Haas. York Univ., Canada.D41 636.6 Monocyte differentiation in the ischemic lung.A. Moldobaeva, L.M. Eldridge, E. Kim and E.M. Wagner.Johns Hopkins Univ.D42 636.7 Mesenchymal stem cells decreasetubulointerstitial injury and improve renal function afterrevascularization in swine atherosclerotic renal artery stenosis.A. Eirin, X. Zhu, V. Urbieta Caceres, J.D. Krier, S.C. Textor, A.Lerman and L.O. Lerman. Mayo Clin.D43 636.8 Vasodilation responses to matricryptic plasmafi bronectin fragments attenuated by growth factors. A.M. Dewar,R.A. Clark and M.D. Frame. Stony Brook Univ.D44 636.9 Vasodilation responses to matricryptic plasmafi bronectin peptides depend on beta adrenergic receptorpathways. A.M. Dewar, R.A. Clark and M.D. Frame. StonyBrook Univ.D45 636.<strong>10</strong> AvB3 integrin and airway angiogenesis. M.G.Perino, J. Jenkins, G.M. Lanza and E.M. Wagner. JohnsHopkins Univ. and Washington Univ.D46 636.11 Renal microvascular proliferation andremodeling in swine with metabolic syndrome. Z. Li, J.R.Woollard, X. Zhu, S.C. Textor, A. Lerman and L.O. Lerman.Mayo Clin.D47 636.12 Adaptation of microvascular networks to localoxygenation: functional roles of tissue, vessel wall and RBCsignalling B.E. Reglin, T.W. Secomb and A.R. Pries. Charité-Berlin and Univ. of Arizona.D48 636.13 Mitochondrial respiration is required for theadipogenic differentiation of human mesenchymal stem cells.Y. Zhang, P.T. Toth, G. Marsboom, J.D. Paul and J. Rehman.Univ. of Chicago.D49 636.14 Integration of donor bone marrow cells into thecochlea at one year. X. Shi and A.L. Nuttall. Oregon Hlth. &Sci. Univ.D50 636.15 Systemic hypoxia reverses whole brainradiation-induced microvascular rarefaction. J.P. Warrington,A. Csiszar, D.A. Johnson, T.S. Herman, S. Ahmad, Y.W.Lee and W.E. Sonntag. Univ. of Oklahoma Hlth. Sci. Ctr. andVirginia Tech.D51 636.16 Tumor necrosis factor alpha contributes tovascular dysfunction and skeletal muscle microvascularrarefaction in the obese Zucker rat. A.G. Goodwill, J.T. Butcherand J.C. Frisbee. West Virginia Univ.D52 636.17 Temporal progression of microvascularrarefaction in the metabolic syndrome. A.G. Goodwill and J.C.Frisbee. West Virginia Univ.637. ATHEROSCLEROSIS/THROMBOSIS/PLATELETSPoster(Sponsored by: The Microcirculatory Society)SUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-3:00 PM<strong>SUNDAY</strong>D53 637.1 Tamoxifen activates calcium infl ux inhuman platelets via NADPH oxidase/PI3 kinase pathway. Y.Dobrydneva, V. Shah and P. Blackmore. Eastern VirginiaMed. Sch.D54 637.2 Transglutaminases affect plaque compositionand size in regions exposed to oscillatory shear stress. E.N.T. P. Bakker, H.L. Matlung, H.C. Groen, K. van Gaalen, J.D.van Buul, J.J. Wentzel and E. VanBavel. Acad. Med. Ctr.,Amsterdam, Erasmus Med. Ctr., Rotterdam and Sanquin Res.and Landsteiner Lab., Amsterdam.D55 637.3 Fibrinogen gamma’ carboxyl terminus inhibitsthrombin cleavage of protein C. J.P. Ramsey, A.S. Ashtekar,D.H. Farrell and R.S. Lovely. Missouri State Univ. and OregonHlth. & Sci. Univ.D56 637.4 Similarity in responses seen in atherogenicrabbits treated with soy fl our or superoxide dismutase. A.L.Van Blaricom, R.J. Acosta and E.L. Beard. Loyola Univ. NewOrleans.D57 637.5 Angiopoietin like-2 increases with aging andatherosclerosis. N. Farhat, N. Thorin-Trescases, B.G. Allenand E. Thorin. Montreal Heart Inst.186
<strong>SUNDAY</strong>D58 637.6 Tetrahydrobiopterin defi ciency and nitric oxidesynthase uncoupling contribute to atherosclerosis inducedby disturbed fl ow. L. Li, W. Chen, A. Rezvan, H. Jo and D.G.Harrison. Emory Univ.D59 637.7 Activated endothelial cells enhance plateletresponses to dynamic shear stress conditions. W. Yin, F. Roufand D.A. Rubenstein. Oklahoma State Univ.D60 637.8 The binding site for fi brin-derived peptideγ 370-383 (P3) in the α IIbβ-propeller of integrin α IIbβ 3. N.P.Podolnikova, V.P. Yakubenko and T.P. Ugarova. Arizona StateUniv. and Cleveland Clin.D61 637.9 Antioxidants aleviate nicotine-induced plateletaggregation in cerebral arterioles of mice in vivo. M.A. Fahim,A. Nemmar and M.Y. Hassan. United Arab Emirates Univ.D62 637.<strong>10</strong> Platelet-derived TLR4 mediates LPS-enhancedmicrovascular thrombosis. R.J. Stark and R.E. Rumbaut.Baylor Col. of Med.638. INFLAMMATION/LEUKOCYTE-ENDOTHELIALINTERACTIONSPoster(Sponsored by: The Microcirculatory Society)SUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-3:00 PMD63 638.1 Mechanisms of leukocyte and plateletrecruitment in the microvasculature during chronic angiotensinII administration. A. Yildirim and D.N. Granger. LSU Hlth. Sci.Ctr., Shreveport.D64 638.2 Mechanical ventilator-induced pulmonaryinjury in the obese Zucker rats. L. Xiang, J.S. Naik, S. Lu andR.L. Hester. Univ. of Mississippi Med. Ctr. and Lovelace Resp.Res. Inst., Albuquerque.D65 638.3 Anti-infl ammatory effect of statins in anatherosclerosis-related coculture model. H. Loppnow, M.Buerke, A. Schlitt, U. Müller-Werdan and K. Werdan. MartinLuther Univ. Halle-Wittenberg, Germany.D66 638.4 The role of endothelial nitric oxide synthaseuncoupling on leukocyte-endothelial interactions in ratmesenteric postcapillary venules. M.A. Kern, L.H. Young, B.Rueter, E.S. Iames and Q. Chen. Philadelphia Col. of Osteo.Med.D67 638.5 Protease activity increases in plasma afterhemorrhagic shock. A.H. Penn and G.W. Schmid-Schönbein.UCSD.D68 638.6 Shear-induced cleavage of CD18 integrins onhuman granulocytes, monocytes and lymphocytes D. Zhanand H.Y. Shin. Univ. of Kentucky.D69 638.7 The in vitro effects of different concentrationsof glucose on innate immune cell activation. P.J. Horvath, G.Ganesan, S. Oliver, F. Zaldivar, Jr., S. Radom-Aizik and P.Galassetti. Univ. of California, Irvine.D70 638.8 Membrane cholesterol enrichment altersleukocyte shear responses via an effect on membrane fl uidity.X. Zhang, J. Hurng, D.L. Rateri, A. Daugherty, G.W. Schmid-Schönbein and H.Y. Shin. Univ. of Kentucky and UCSD.D71 638.9 CAM-mediated endocytosis contributes toleukocyte transcellular transmigration. D. Serrano, M. Meng, R.Chadha, C. Garnacho and S. Muro. Univ. of Maryland CollegePark and Univ. of Pennsylvania Med. Sch.D72 638.<strong>10</strong> Increased platelet activating factor productionin T. cruzi infected endothelial cells. J. Sharma, D.F. Hoft andJ. McHowat. Saint Louis Univ.D73 638.11 The effect of second hand smoke and inhibitoryrole of low dose aspirin on shear stress-stimulated endothelialcells. S.K. Shanmugavelayudam, D.A. Rubenstein and W.Yin. Oklahoma State Univ.D74 638.12 Endothelial pro-coagulant responses in acidinducedlung injury. S. Bhattacharya and M.T. Emin. ColumbiaUniv. Med. Ctr. and St. Lule’s-Roosevelt Hosp. Ctr.D75 638.13 Computational model for oxidative andnitrosative stress for endothelial dysfunction related leukocyteadhesion and transmigration. S. Kar and M. Kavdia. WayneState Univ.D76 638.14 Blood viscosity and the expression ofinfl ammatory and adhesion markers in homozygous S sicklecell disease with chronic leg ulcers. A. Bowers, J. Knight-Madden, D. Pepple, H. Reid and M. Reid. Univ. of West Indies,Jamaica.D77 638.15 Modulation of intestinal infl ammation in a modelof infl ammatory bowel disease by manipulation of dendriticcells. E. Rivera, H. Marty, M.L. Cruz and C.B. Appleyard.Ponce Sch. of Med., PR.D78 638.16 Phospholipase C epsilon is a critical mediatorof NF-κB activation and vascular cell adhesion molecule-1expression in endothelial cells. K.M. Bijli, W.B. Alexander, F.Fazal and A.V. Smrcka. Univ. of Rochester.D79 638.17 Prolyl hydroxylase inhibition attenuates mastcell degranulation during systemic hypoxia via upregulationof inducible nitric oxide synthase. J.G. Wood, N.B. Holloway,M. Moncure, J.H. Thomas, A.J. Casillan and N.C. Gonzalez.Univ. of Kansas Med. Ctr.D80 638.18 Persistent cytomegalovirus infection acceleratesnon-complicated obesity-induced venular infl ammation in amouse model. M. Khoretonenko and K. Stokes. LSU Hlth.Sci. Ctr., Shreveport.D81 638.19 Attenuation of fl uid shear response by proteolyticcleavage of the formyl peptide receptor on neutrophils of thespontaneously hypertensive rat. A.Y. Chen, F.A. DeLano, S.R.Valdez, J.N. Ha, H.Y. Shin and G.W. Schmid-Schönbein.UCSD and Univ. of Kentucky.D82 638.20 FPR2/ALX as an anti-infl ammatory target inthe treatment of sepsis. E.L. Hughes, J.C. Buckingham andF.N. Gavins. Imperial Col. London.D83 638.21 Intravenous injection of keratose resuscitationfl uid restores arteriolar diameter in striated muscle ofhemorrhaged rats. F.A. Nunez, J. Villa, M. Callahan, T. Smithand M. Van Dyke. Wake Forest Univ. and Univ. of MassachusettsAmherst.639. ISCHEMIA-REPERFUSION/FREE RADICALS/PATHOBIOLOGYPoster(Sponsored by: The Microcirculatory Society)SUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-3:00 PMPHYSIOLOGYD84 639.1 Simulating vascular remodeling and transportin tumors. L. Munn, C. Kunert, W. Kamoun and J.A. Tyrrell.Massachusetts Gen. Hosp., Charlestown and ThomsonReuters, NY.187SUN
PHYSIOLOGYD85 639.2 Alterations in hepatic tumor cell colonizationduring obesity. H.A. O’Leary, A. Kothur, A.G. Goodwill, J.C.Frisbee and R.W. Brock. West Virginia Univ.D86 639.3 Ischemia-reperfusion decreases hydrogensulfi de production in the kidney. K. O, G. Prathapasinghe, N.Wu and Y.L. Siow. Univ. of Manitoba and Agr. and Agri-FoodCanada, Winnipeg.D87 639.4 Effects of protein kinase C broad spectruminhibitor Gö 6983 on real-time blood nitric oxide and hydrogenperoxide release in femoral artery/vein ischemia andreperfusion. K.D. Bartol, K-A. Perkins, Q. Chen and L.H.Young. Philadelphia Col. of Osteo. Med.D88 639.5 Soluble guanylate cyclase activation preventspostischemic infl ammation in wild type and heme oxygenase-1KO mice. W.Z. Wang, A.W. Jones, M. Wang, M.Y. Zuidema, W.Durante and R.J. Korthuis. Univ. of Missouri-Columbia.D89 639.6 Excess Ca 2+ enhances ROS generation frominhibited complex III with FADH 2-linked substrate but notNADH-linked substrate. M. Aldakkak, D.F. Stowe, R.K. Dash,M.L. Riess and A.K. S. Camara. Med. Col. of Wisconsin.D90 639.7 Role of reactive oxygen species in postischemicleukocyte rolling and adhesion in male and female plasminogenactivator inhibitor type-1 knockout mice. M. Wang, W. Fay andR.J. Korthuis. Univ. of Missouri-Columbia.D91 639.8 Neuroprotective mechanisms of cerium oxidenanoparticles. W. Mosenthal, M.D. Nieves, A. Beideck, J.S.Erlichman and A.Y. Estevez. St. Lawrence Univ., NY.D92 639.9 Pharmacological postconditioning byintracoronary adenosine in a porcine model of acute myocardialinfarction. M. te Lintel Hekkert, S. Tel, D. Merkus, P.W. Serruys,W.J. van der Giessen and D.J. Duncker. Erasmus Med. Ctr.,Rotterdam.D93 639.<strong>10</strong> Antioxidant diet is not effective in kidneyischemia/reperfusion injury. S.R. Inman, T. Hayes, Y. Slyvkaand F.V. Nowak. Ohio Univ.D94 639.11 Chronic resveratrol treatment alleviatesmyocardial ischemia injury in a hypertensive model. K.K.Durham, C.S. Smith and J.W. E. Rush. Univ. of Waterloo,Canada.D95 639.12 Cannabidiol protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, infl ammatoryresponse, and cell death. S. Batkai, P. Mukhopadhyay, B.Horvath, M. Rajesh, G. Hasko, D.A. Wink and R. Mechoulam.NIAAA and NCI, NIH, UMDNJ, Newark and Hebrew Univ. ofJerusalem.D96 639.13 Effect of hyponatremia in isolated rat hearts. D.Lee, R. Quarrie, J.L. Zweier and J.A. Crestanello. Ohio StateUniv.D97 639.14 Peroxynitrite produced during cardiacischemia-reperfusion injury induces nitration of mitochondrialvoltage-dependent anion channel. M. Yang, A.K. S. Camara,W-M. Kwok, B.T. Wakim, A.K. Gadicherla, M. Aldakkak, A.D.Boelens, J.S. Heisner and D.F. Stowe. Med. Col. of Wisconsinand VA Med. Ctr.D98 639.15 Catecholamines and high calcium increasethe susceptibility of the isolated rabbit heart to ischemia- andreperfusion-induced ventricular tachyarrhythmias. H. Clements-Jewery and C. Tanga. West Virginia Sch. of Osteo. Med.D99 639.16 Enhancing complement control on theendothelial barrier protects kidney allografts by modulatingimmune response. S. Pushpakumar, G. Perez-Abadia, C.Soni, T. Fensterer and C. Maldonado. Univ. of Louisville.D<strong>10</strong>0 639.17 Cardiolipin degradation during cardiacischemia reperfusion injury: partial restoration by ranolazine.A.K. Gadicherla, A.K. S. Camara, M. Yang and D.F. Stowe.Med. Col. of Wisconsin.D<strong>10</strong>1 639.18 Membrane enhanced complement controlreduces endothelial cell activation and injury. T.M. Fensterer,P. Patibandla, S. Pushpakumar, G. Perez-Abadia, C. Soni, P.Bauer and C. Maldonado. Univ. of Louisville and EndoProtechInc., Louisville.D<strong>10</strong>2 639.19 ECHDC2, a novel mitochondria proteinis abundantly expressed in SS rat hearts: implications forischemia/reperfusion injury J. Du, T. Guan, Q. Yang, H. Xu, S.Welak, K.A. Prichard, Jr., A.K. S. Camara and Y. Shi. Med.Col. of Wisconsin.D<strong>10</strong>3 639.20 Resveratrol improves renal blood fl ow andmicrocirculation in the kidney during experimental septic shockin mice. J.H. Holthoff, Z. Wang, K.A. Seely and P.R. Mayeux.Univ. of Arkansas for Med. Sci.D<strong>10</strong>4 639.21 Role of CD4 + T cells in reperfusion-inducedvascular injury. M.Y. Zuidema, Y. Park, Y. Zhang, J. Wu and C.Zhang. Univ. of Missouri Columbia Sch. of Med.D<strong>10</strong>5 639.22 Effect of topical application of cyanide andnitroglycerin on local oxygen consumption at rest and following1 minute of ischemia in the rat spinotrapezius muscle. W.H.Nugent, A.S. Golub, B.K. Song and R.N. Pittman. VirginiaCommonwealth Univ.640. HYPERTENSIONPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-3:00 PM<strong>SUNDAY</strong>D<strong>10</strong>6 640.1 Skeletal muscle metaborefl ex overactivity ismediated by the TRPv1 receptor in spontaneously hypertensiverats. M. Mizuno, M.N. Murphy, J.H. Mitchell and S.A. Smith.Univ. of Texas Southwestern Med. Ctr.D<strong>10</strong>7 640.2 Reactive oxygen species mediate agonistinducedTRPC6 activation in vascular smooth muscle cells.Y. Ding, M. Ding, S.M. Graham, I. Akopova, S. Muallem, L.Birnbaumer and R. Ma. Univ. of North Texas Hlth. Sci. Ctr.,NIDCR, NIH and NIEHS, NIH, Research Triangle Park.D<strong>10</strong>8 640.3 Endothelin B receptor-mediated activation ofNADPH oxidase alters norepinephrine-related gene expressionin PC-12 cells. C.L. Henley, X. Cao and D.L. Kreulen. MichiganState Univ. and Weill Cornell Med. Col.D<strong>10</strong>9 640.4 Augmented angiotensin II signalling inresistance vessels from smooth muscle specifi c dominantnegative PPARG transgenic mice. M. A.C. Sepulveda, P.Ketsawatsomkron and C.D. Sigmund. Univ. of Iowa.D1<strong>10</strong> 640.5 Exercise pressor refl ex induced FOS expressionis co-localized with neurons containing neuronal nitric oxidesynthase in the nucleus tractus solitarius. M.N. Murphy, M.Mizuno and S.A. Smith. Univ. of Texas Southwestern Med.Ctr.D111 640.6 Intrathecal kynurenate decreases arterialpressure in conscious DOCA-salt hypertensive rats.B. Veitenheimer and J. Osborn. Univ. of Minnesota,Minneapolis.188
<strong>SUNDAY</strong>D112 640.7 Contribution of oxidant stress to endothelialdysfunction in middle cerebral arteries of fawn-hoodedhypertensive rats. B.D. Weinberg and J.H. Lombard. Med.Col. of Wisconsin.D113 640.8 Cardiac sympathetic nerves do not contributeto AngII-salt hypertension. D.M. Hirsch and J. Osborn. Univ.of Minnesota Med. Sch.D114 640.9 Protein phosphatase 1(PP1) binds to WNK4and regulates WNK4 interaction with SGK1 and c-Src. P. Yue,D. Lin and W. Wang. New York Med. Col.D115 640.<strong>10</strong> Peripheral chemoreceptor inputs contributeto the development of high blood pressure in spontaneouslyhypertensive rats. A.P. L. Abdala, J.F. R. Paton and A.Gourine. Univ. of Bristol and University Col. London.D116 640.11 Augmented S-nitrosylation contributes toimpaired relaxation in angiotensin II hypertensive mouse aorta:role of thioredoxin reductase. H. Choi and R.C. Webb. Med.Col. of Georgia.D117 640.12 Treatment with tumor necrosis factor-? blocker,etanercept, attenuates the angiotensin II-induced hypertensiveresponse in eNOS knockout mice C. Whiting, A. Castillo, D.Agarwall, J. Francis and D. Majid. Tulane Sch. of Med. andLSU Sch. of Vet. Med.D118 640.13 Urinary renin excretion is increased in chronicangiotensin II-infused hypertensive rats. L. Liu, D.M. Seth,L.G. Navar and M.C. Prieto. Tulane Univ. Sch. of Med. andHyperten. and Renal Ctr. of Excellence, New Orleans.D119 640.14 Mechanisms of aortic stiffness in salt-sensitivehypertension. W.E. Rodriguez-Alvarez, P. Kumar, R. Lawal,C. Harris, B. Williams, A. S. O. Adeagbo, S.C. Tyagi and I.G.Joshua. Univ. of Louisville and Commonwealth Med. Col., PA.D120 640.15 The effects of an herbal extract SPOO2P onvascular relaxation responses. W.E. Rodriguez-Alvarez, R.Lawal, N. Perumal, C. Harris, B. Williams, A. Adeagbo andI.G. Joshua. Univ. of Louisville and Commonwealth Med. Col.D121 640.16 Endothelial damage refl ected by circulatingendothelial cells in young patients with latent or manifesthypertension. N.P. Lyamina, S.V. Lyamina, V.N. Senchikhin,K.A. Dodina, E.B. Manukhina and H.F. Downey. Res. Inst. ofCardiol., Saratov, Moscow State Univ. of Med. and Dent., Inst.of Gen. Pathol. and Pathophysiol., Moscow and Univ. of NorthTexas Hlth. Sci. Ctr.D122 640.17 Evidence that cell-free hemoglobin induces ratpulmonary artery smooth muscle cell proliferation by decreasingnuclear cyclic AMP response element binding protein by amechanism(s) other then oxidative stress. D. Irwin, C. Lisk, I.Connor, E. Forchielli, C. Garat-Carter and D. Klemm. Univ. ofColorado Denver, Aurora.D123 640.18 Cortisol and dexamethasone-induced hypertensionincreased intramuscular nitric oxide levels in fetalprogrammed hypertensive rats. S. Fabris, T.C. Tai and D.MacLean. Northern Ontario Sch. of Med. and Laurentian Univ.,Canada.D124 640.19 Orchidectomy reduced abdominal aortarelaxation response to androgens in Sprague-Dawley rats feda high-salt diet. A.K. Oloyo, O.A. Sofola, C.N. Anigbogu, R.R.Nair and V. Harikrishnan. Univ. of Lagos, Nigeria, Sree ChitraTirunal Inst. for Med. Sci. and Technol., India.D125 640.20 Inhibition of nitric oxide-GABA pathway byreactive oxygen species in the rostral ventrolateral medullacauses sympathoexcitation in SHRSP. K. Shinohara, Y.Hirooka, T. Kishi and K. Sunagawa. Kyushu Univ. Grad. Sch.of Med. Sci., Japan.PHYSIOLOGYD126 640.21 Inhibition of reactive oxygen species in rostralventrolateral medulla augments sympathoexcitatory effectsfrom the paraventricular nucleus of the hypothalamus inspontaneously hypertensive rats. M. Nishihara, Y. Hirooka, T.Kishi and K. Sunagawa. Kyushu Univ. Grad. Sch. of Med. Sci.,Japan.D127 640.22 A pancreatic source of protease activity in thespontaneously hypertensive rat and its reduction during shorttermfood reduction. A. Chan and G.W. Schmid-Schönbein.UCSD.D128 640.23 2-Kidney 1-clip hypertension restores impairedvascular relaxation in Dahl salt-sensitve rats. A.M. Beyer andJ.H. Lombard. Med. Col. of Wisconsin.D129 640.24 Gastrin stimulates Na, K-ATPase phosphorylationand endocytosis via PI3 kinase-mTOR-S6 kinase andPKC pathways in immortalized renal proximal tubule cells T.Liu and P.A. Jose. Children’s Natl. Med. Ctr.D130 640.25 Increased blood pressure after acuteadministration of low lead concentration depends on the SRAactivation. D.V. Vassallo, M.R. Simões, R.F. Ribeiro Júnior,M.V. A. Vescovi, H.C. de Jesus, A.S. Padilha, I. Stefanon, M.Salaices and M. Fioresi. Fed. Univ. of Espírito Santo, Braziland Autonomous Univ. of Madrid.D131 640.26 In vitro ascorbic acid treatment decreasesresistance-sized mesenteric artery myogenic reactivity inpregnant rats with reduced uterine perfusion pressure. R.J.Ramirez, J.J. Reho, J. Peck and J. Novak. Univ. of Akron andWalsh Univ., OH.D132 640.27 Injection of AMP-activated protein kinaseactivator AICAR acutely reduces blood pressure inspontaneously hypertensive rats. R.J. Ford, S. Teschke andJ.W. E. Rush. Univ. of Waterloo, Canada.D133 640.28 Altered uterine artery reactivity from pregnantrats with reduced uterine perfusion pressure. J.J. Reho, J.Novak and R.J. Ramirez. Univ. of Akron and Walsh Univ.,OH.D134 640.29 TNF alpha does not mediate functional changesin corpora cavernosa from DOCA-salt rats. F. Carneiro, Z.N.Carneiro, F. Giachini, V.V. Lima, R.C. Webb and R.C. Tostes.Med. Col. of Georgia and Univ. of São Paulo, Ribeirão Preto.D135 640.30 Altered phenylephrine-induced vascularcontractility and reduced endothelial function during the onsetof renal wrap hypertension. H. Al-Azawi, S. Gordon, C.A.Northcott and A.K. L. Banes-Berceli. Oakland Univ., MI andMichigan State Univ.D136 640.31 Increasing pressure pulse wave velocitydoes not increase aortic pulse pressure in the elderly. M.W.Mohiuddin, G.A. Laine, W.I. Douglas and C.M. Quick. TexasA&M Univ. and Univ. of Texas Hlth. Sci. Ctr. at Houston.D137 640.32 Scavenging peroxinitrite attenuatesangiotension II-induced hypertension in rats. M.C-W. Chavisand A. Yasir. Tulane Univ.D138 640.33 Higher central and brachial artery systolic andpulse pressure in black overweight/obese adolescents: relationwith aortic stiffness and pressure wave refl ection. G.L. Pierce,H. Zhu, I. Stallmann-Jorgensen, Y. Huang, D. Guo, I. Edet, K.Darracott and Y. Dong. Med. Col. of Georgia.D139 640.34 Abnormal autonomic regulation of the immunesystem in genetic hypertension. S.C. Harwani, M.W. Chapleauand F.M. Abboud. Univ. of Iowa.D140 640.35 Fetal programming of vascular dysfunction.J.A. Thompson, R. Gros, B.S. Richardson and T.R. H.Regnault. Univ. of Western Ontario and Robarts Res. Inst.,London, Canada.SUN189
PHYSIOLOGYD141 640.36 Effect of hypertension on myocardialcannabinoid CB1 receptor expression. M.S. Gole, K.T. Nagallaand D.B. Murray. Univ. of Mississippi.D142 640.37 The role of CD8 + T lymphocytes, IP-<strong>10</strong> andMMP12 in hypertension S.R. Thabet, J. Wu, Y. Blinder, W.Chen, M.S. Madhur, M.C. Gongora, C. Weyand and D.G.Harrison. Emory Univ. and Stanford Univ.D143 640.38 Sleep pattern and serotonin 5HT-1A receptorcleavage in the brain of the spontaneously hypertensive rat.S.R. Valdez, J-Y. Li, R. Mazor, T.B. J. Kuo and G.W. Schmid-Schönbein. UCSD and Natl. Yang-Ming Univ., Taiwan.D144 640.39 Arterial-derived relaxin inhibits myogenicbehavior in small renal arteries isolated from relaxin knockoutmice. J.P. Van Beusecum, J. Fox, R.J. Ramirez, L. Parry, J.Novak and K.P. Conrad. Walsh Univ., OH, Univ. of Akron, Univ.of Melbourne and Univ. of Florida.D145 640.40 Effect of OVLT lesion on AngII-salt hypertensionin the rat. J.P. Collister, A.A. Vieira, D.B. Nahey and J.W.Osborn. Univ. of Minnesota, St. Paul and Minneapolis.D146 640.41 PPAR-α activation decreases pro-infl ammatorycytokines in the plasma, while increasing renal expression ofCYP4A and decreasing COX2 D.L. Lee, J.L. Wilson, R. Duan,T. Hudson and A.A. Elmarakby. Howard Univ. and Med. Col.of Georgia.D147 640.42 Functional role of the neuropeptide Y receptor 2gene in predisposition to hypertension. E. Albino, K. Sugimoto,T. Katsuya, A. Deng and J. Dutil. Ponce Sch. of Med., PR,Osaka Univ. Grad. Sch. of Med. and Univ. of Montreal Hosp.Ctr.641. VASCULAR PATHOBIOLOGYPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-3:00 PMD148 641.1 Aldose reductase mediates VCAM1expression in endothelial cells via Egr1. S. Vedantham, R.Ananthakrishnan, R. Rosario, I. Goldberg, A. M. Schmidtand R. Ramasamy. NYU and Columbia Univ.D149 641.2 Biomechanical stretch triggers varicose veinremodeling in mice through activation of the transcription factorAP-1. T. Korff, A. Feldner, H. Otto and M. Hecker. Univ. ofHeidelberg.D150 641.3 Deletion of vascular smooth muscle Jak2prevents angiotensin II-induced neointima formation followingvascular injury in mice. A. Kirabo, S.P. Oh, H. Kasahara, K-U.Wagner and P.P. Sayeski. Univ. of Florida Gainsville and Univ.of Nebraska Med. Ctr.D151 641.4 Role of oxidative stress in arterial dysfunctionin type 2 diabetes mellitus. W.E. Rodriguez-Alvarez, R. Lawal,C. Harris, B. Williams, A. S. O. Adeagbo, I.G. Joshua andS.C. Tyagi. Univ. of Louisville and Commonwealth Med. Col.D152 641.5 A new approach to clearly identify collagenfi bers/fi brils and infl ammatory cells from H&E stained murinelung sections using fl uorescent microscopy. P.M. Wang andW.J. Martin II. NICHD, NIH.D153 641.6 Atherosclerosis-upregulated infl ammatorygene mRNAs have signifi cant structural features for beingregulated by microRNAs. A.T. Virtue, J. Mai, Y. Yin, X. Jiang,H. Wang and X-F. Yang. Temple Univ.<strong>SUNDAY</strong>D154 641.7 microRNAs and other mechanisms regulatethe expressions and structures of interleukin-17 cytokines andreceptors. J. Mai, A.T. Virtue, E. Maley, T. Tran, Y. Yin, X. Jiang,H. Wang and X-F. Yang. Temple Univ.D155 641.8 TLR4-induced upregulation of NALP3 isassociated with increased caspase-1 activity in human aorticendothelial cells. Y. Yin, J. Mai, A.T. Virtue, X. Jiang, H. Wangand X-F. Yang. Temple Univ. Sch. of Med.D156 641.9 Sodium nitrite treatment de-stiffens large elasticarteries in old mice: modulation of advanced glycation endproducts.B.S. Fleenor, A.L. Sindler, N.K. Marvi, N. Claassen,J.W. Calvert, D.J. Lefer and D.R. Seals. Univ. of Colorado atBoulder and Emory Univ.D157 641.<strong>10</strong> Acetylbritannilactone suppresses growth viaupregulating KLF4 expression in HT29 colorectal cancer cells.X.M. Fang, B. Liu, Y.B. Liu, J.J. Wang and B.H. Li. Hebei Med.Univ., and Fourth Affi liated Hosp., People’s Republic of China.D158 641.11 Differential endothelin ETA and ETB receptoractivity in the cephalothoracic and abdominal blood vessels ofmale rat. O.M. Reslan and R.A. Khalil. Brigham and Women’sHosp.D159 641.12 Hypercholesterolemia and angiotensin-mediatedhypertension act synergistically to produce aortic stenosis inmiddle-aged mice. R.M. Weiss, R. Sabharwal, K.A. Zimmermanand M.W. Chapleau. Univ. of Iowa and VA Med. Ctr.D160 641.13 Role of protease-activated receptor-4 in thephosphorylation of extracellular regulated kinase in vascularsmooth muscle cells. T. Epperson, L. Tillery, J. Mantey, A.Austin and E. Motley. Meharry Med. Col.D161 641.14 ATRA activates and PDGF-BB represses theSM22α promoter through KLF4 binding to or dissociating fromits cis-DNA elements. K. Yu, M. Han, B. Zheng and J. Wen.Hebei Med. Univ., People’s Republic of China.D162 641.15 Cutaneous vasodilation in response to localheating is impaired in chronic kidney disease. J. DuPont, W.Farquhar, R. Townsend and D.G. Edwards. Univ. of Delawareand Univ. of Pennsylvania.D163 641.16 Arginase inhibition does not improve aorticendothelial-dependent relaxation in rats with chronic kidneydisease. C.R. Martens, T. Schellhardt, S.L. Lennon-Edwardsand D.G. Edwards. Univ. of Delaware.D164 641.17 Perivascular adipose tissue function in a modelof metabolic syndrome. T. Szasz, S. Goulopoulou and R.C.Webb. Med. Col. of Georgia.D165 641.18 Effects of voluntary exercise on epigeneticregulation and vascular properties in a model of dyslipidemia.A.Q. Nguyen, S. Geoffroy, N. Duquette, M-A. Gillis, M. Lebel,D. Bachvarov, M. Phillips and E. Thorin. Montreal Heart Inst.,Univ. of Montreal, Laval Univ. and Hotel-Dieu de Québec.D166 641.19 Abdominal aortic aneurysm formation requiresprotein kinase C-delta-mediated apoptosis and MCP-1production. S. Morgan, C. Harberg, D. Yamanouchi and B.Liu. Univ. of Wisconsin-Madison.D167 641.20 The role of Smad3 in TGF beta signaling inmouse aorta and smooth muscle cells. R.P. Metz, N. Popovic,D.W. Howell and E. Wilson. Texas A&M Hlth. Sci. Ctr.D168 641.21 Activation of nuclear factor of activated T cellsin retinal vessels of diabetic Ins2 Akita mice. O. Kotova, A.V.Zetterqvist, L.M. Berglund, R. Al-Naemi, P.G. McGuire, L.V.Gonzalez Bosc and M.F. Gomez. Lund Univ., Sweden andUniv. of New Mexico Hlth. Sci. Ctr.D169 641.22 Transforming growth factor beta signaling inMarfan syndrome. D.W. Howell, R. Metz, N. Popovic and E.Wilson. Texas A&M Hlth. Sci. Ctr.190
<strong>SUNDAY</strong>D170 641.23 Altered protein expression of coronaryperivascular adipose tissue in metabolic syndrome. M. Kohr,G.A. Payne, X. Lai, F.A. Witzmann and J.D. Tune. IndianaUniv. Purdue Univ. Indinapolis.D171 641.24 Endothelial Ca 2+ signals and vasodilatoryfunction following traumatic brain injury. B. Larson, R.M.Hannah, S.K. Sonkusare, G.C. Wellman, M.T. Nelson and K.Freeman. Univ. of Vermont.D172 641.25 A novel phosphorylation-deacetylation cascademediates Am80 induced p21 expression in VSMCs. B. Zheng,M. Han, Y-n. Shu, Y-j. Li, S-b. Miao, X-h. Zhang, H-j. Shi, T.Zhang and J-k. Wen. Hebei Med. Univ., People’s Republic ofChina.D173 641.26 Royal jelly recovers erectile function viaimproved endothelial-mediated pudendal artery relaxationin aged spontaneously hypertensive rats. J.L. Hannan, C.S.Rigsby and R.C. Webb. Med. Col. of Georgia.642. SHOCKPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-3:00 PMD174 642.1 Enhanced voltage-dependent Ca 2+ signalingcontributes to the increase in catecholamine release frompostganglionic sympathetic neurons and adrenal chromaffi ncells during sepsis. M.K. Lukewich and A.E. Lomax. Queen’sUniv., Canada.D175 642.2 Effects of high protein feeding and insulin onliver antioxidant status in rats subjected to burn injury andhindlimb unloading. M.A. Dubick, J.L. Barr, L.A. Baer, X. Wuand C.E. Wade. U.S. Army Inst. of Surg. Res., San Antonio.D176 642.3 Increased plasma arginase activity contributesto acute lung injury following resuscitation with stored packedred blood cells in a rat model of trauma/hemorrhage. F.K.Johnson, W. Durante, R.A. Johnson, T. Craig, J.G. Myersand R.M. Stewart. Univ. of Texas Hlth. Sci. Ctr. at Sam Antonioand Univ. of Missouri-Columbia.D177 642.4 Hemoperitoneum: abdominal blood,endogenous carbon monoxide and hemostasis R.A. Johnson,S.L. Crandall, B.M. Irle, T. Craig, F.K. Johnson and R.M.Stewart. Univ. of Texas Hlth. Sci. Ctr. at San Antonio.D178 642.5 Therapeutic targeting of the venous circulationto increase blood pressure in a rat model of septic shock. K.M.Thakali, P.R. Mayeux and N.J. Rusch. Univ. of Arkansas forMed. Sci.D179 642.6 Toll-like receptor-4 defi ciency rescues anthraxlethal toxin-elicited cardiac contractile dysfunction: role ofautophagy. M.R. Kandadi, A.E. Frankel and J. Ren. Univ. ofWyoming and Scott & White Mem. Hosp., Temple, TX.D180 642.7 Phase relationships between mean arterialpressure and intraosseous pressure. J.A. Ward, R.A.DeLorenzo, B.J. Rubal, B.S. Jordan, J.S. Medina, V.L.Holbrook-Emmons and C.E. Hanson. Brooke Army Med. Ctr.and U.S. Army Inst. of Surg. Res., Fort Sam Houston.D181 642.8 Paradoxical bradycardic response to murinehemorrhagic shock onset predicts cardiovascular functionand survival after resuscitation. A. Desai, D.G. Beiser, N.R.Prabhakar and T.L. Vanden Hoek. Univ. of Chicago.D182 642.9 Digestive degradation of intestinal mucinduring splanchnic ischemia. M. Chang, E.B. Kistler and G.W.Schmid-Schönbein. UCSD, La Jolla and San Diego.D183 642.<strong>10</strong> Blockade of pancreatic proteases—possibletherapeutic utility. F.A. DeLano and G.W. Schmid-Schönbein.UCSD.643. NITRIC OXIDE/CARBON MONOXIDE/VASOACTIVE MOLECULESPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-3:00 PMPHYSIOLOGYD184 643.1 Effects of nitric oxide-active botanicals onbiomarkers of cardiovascular risks: a proof of concept inhumans. N. Bryan. Univ. of Texas-Houston Hlth. Sci. Ctr.D185 643.2 Dynamics of intrahepatic nitric oxide (NO)using selective NO sensor during hepatic ischemia-reperfusionin rat liver. A. Nakagawa, Y. Yokoyama, T. Kokuryo, T. Seki, H.Suzuki, K. Shoji, Y. Watanabe and M. Nagino. Nagoya Univ.Grad. Sch. of Med.D186 643.3 CYP2C7 is an EET synthase in arteriolarendothelium of NO-defi cient female rats. A. Huang, D. Sunand G. Kaley. New York Med. Col.D187 643.4 BAY 41-2272 inhibits PDE activity in rat primaryVSMCs. S. Adderley, C. Joshi, D. Martin and D. Tulis. EastCarolina Univ.D188 643.5 Activation of nitric oxide (NO)-insensitivesoluble guanylate cyclase does not provide greater benefi tthan NO-sensitive stimulation in acute and chronic modelsof cardiovascular disease associated with oxidative stress.M.H. Costell, R.E. Bernard, H. Alsaid, J.J. Upson, A.R.Olzinski, L.A. Morgan, P.O. Grondin, N. Ancellin, N. Dodic,F. Gellibert, B.M. Jucker, L.J. Jolivette, R.N. Willette, C.G.Schnackenberg and D.J. Behm. GlaxoSmithKline, King ofPrussia, PA and GlaxoSmithKline, Les Ulis, France.D189 643.6 Chronic high salt intake: effect on bloodpressure, myocardial structure and local renin-angiotensinsystem I.A. Katayama, E.P. B. Dopona, D.N. Ferreira and J.C.Heimann. Univ. of São Paulo.D190 643.7 Differential regulation of NOS in kidney andheart of SHR fed high-salt diet. J. Varagic, S. Ahmad, J. Habibi,J.R. Sowers and C.M. Ferrario. Wake Forest Univ. and Univ. ofMissouri -Columbia.D191 643.8 Chronic mild and unpredictable stressdecreases nitric oxide in the rat thoracic aorta. F.K. Marcondes,B.S. Almeida, A. Sanches, R. Costa, M.C. P. Franco, B.F.Ponzio, Z.B. Fortes, M. J.C. S. Moura, M.D. Nogueira andD.E. Casarini. Piracicaba Dent. Sch., Univ. of Campinas, Fed.Univ. of São Paulo, Univ. of Campinas and Pontifi cal CatholicUniv. of Campinas, Brazil.D192 643.9 BPPs from Bothrops jararaca venom changerenal function of SHR. D.A. Ianzer, K.D. Silveira, M.M. Teixeira,A. Simões e Silva and A.C. M. Camargo. Butantan Inst., SãoPaulo and Fed. Univ. of Minas Gerais, Brazil.D193 643.<strong>10</strong> Antihypertensive effect of BPP-5a isindependent of bradykinin potentiation or ACE inhibition. D.A.Ianzer, C.H. Xavier, F.C. Fraga, R.Q. Lautner, L.T. Machado,E.P. Mendes, A. C.M. Camargo and R.A. S. Santos. Inst.Butantan, São Paulo and Fed. Univ. of Fed. Univ. of MinasGerais, Brazil.SUN191
PHYSIOLOGYD194 643.11 Leptin improves vascular function by increasingNO formation by an eNOS-independent pathway. K. Schröder,S.B. Benkhoff and R.P. Brandes. Goethe Univ., Frankfurt amMain.D195 643.12 The role of ANG II — NAD(P)H oxidase andcardiac NO bioavailability in response to a low salt diet. Y.Skayian-Ervolina, H. Huang and T.H. Hintze. New York Med.Col.D196 643.13 Intermittent hypoxia in rats reduces hydrogensulfi de activation of large-conductance Ca 2+ -activatedpotassium channels in mesenteric arteries. O. Jackson-Weaver, M.A. Riddle, L. Gonzalez Bosc, D.A. Paredes, B.R.Walker and N.L. Kanagy. Univ. of New Mexico.D197 643.14 Nitroxyl anion reverses endothelin-1-mediatedvascular dysfunction through a reduction in peroxynitritegeneration. B.M. Wynne, H. Labazi, H. Choi, R.C. Tostesand R.C. Webb. Med. Col. of Georgia and Univ. of São Paulo,Ribeirão Preto.D198 643.15 Fructose consumption impairs oxygenutilization in skeletal muscle: involvement of NO and superoxide.E. Kertowidjojo, S. Song and T. Hintze. New York Med. Col.D199 643.16 Mild hyperhomocysteinemia impairs energyproduction effi ciency but not exercise capacity in pregnant rats:role of superoxide, NO and the NADPH oxidase S. Song, E.Kertowidjojo and T. Hintze. New York Med. Col.D200 643.17 Soluble guanylate cyclase catalyzes nitritereduction to nitric oxide in rat aortic smooth muscle cells. K.Madrasi, N. Tsoukias and M. Joshi. Florida Intl. Univ.D201 643.18 Agmatine produced by arginine decarboxylaseactivity causes NO dependent rat mesenteric artery relaxation.T. Gadkari, N. Tsoukias and M. Joshi. Florida Intl. Univ.D202 643.19 Effect of free hemoglobin on NO bioavailabilityin microcirculation: a computational model. P. Deonikar and M.Kavdia. Wayne State Univ.D203 643.20 Thromboxane (TxA 2) attenuates prostacyclin(PGI 2) production in male rat aorta via TxA 2receptor (TP)and protein kinase C. S.C. Birdwell, M.M. Sellers and J.N.Stallone. Texas A&M Univ.D204 643.21 Increased salt concentration in the culturemedia induces redox imbalance in macrophage cells. M.T.Islam, D. Agarwal, J. Francis and D.S. A. Majid. Tulane Univ.Hlth. Sci. Ctr. and LSU Sch. of Vet. Med.D205 643.22 Carbon monoxide attenuates Ang II-inducedvascular hypertrophy via inhibition of NOX1. A.I. Rodriguezand P.M. Bauer. Univ. of Pittsburgh.D206 643.23 Hypoxia-induced upregulation of arginase IIand argininosuccinate synthetase I in human lung microvascularendothelial cells. K. Krotova, S. Zharikov, E. Block and J.Patel. Univ. of Florida and Malcom Randall VA Med. Ctr.D207 643.24 Ischemia-reperfusion injury targets endothelialspecifi c NADPH, resulting in endothelial dysfunction in theisolated heart L.A. Reyes, C. Dumitrescu, T-Y. Wang, L.Druhan and J.L. Zweier. Ohio State Univ.D208 643.25 Hydrogen sulfi de mitigates homocysteinemediatedmitophagy. U. Sen, N. Qipshidze, S. Givvimani,P.K. Mishra, C. Munjal, N. Tyagi and S.C. Tyagi. Univ. ofLouisville.D209 643.26 Inhibition of cystathionine beta-synthasedecreases acetylcholine-mediated relaxation in murine aortaand mesenteric arteries. H. Labazi, B.M. Wynne and R.C.Webb. Med. Col. of Georgia.644. CARDIAC FUNCTION AND DYNAMICSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-3:00 PM<strong>SUNDAY</strong>D2<strong>10</strong> 644.1 Chronic spinal cord injury causes vascularstiffness with depressing cardiac hemodynamics. S-C. Huangand J-S. Wang. Chan Gung Mem. Hosp. and Chan Gung Univ.,Taiwan.D211 644.2 Adenosine prevention of the dense microtubulenetwork during decompensated cardiac hypertrophy involvesp21-activated kinase 1 inhibition. J.G. Wallenborn, G. Cheng,D. Kuppuswamy and G. Cooper. Med. Univ. of SouthCarolina.D212 644.3 Effect of the order of postural change oncirculatory dynamics in healthy adults. M. Haga, M. Nagai, H.Chiba, K. Sasaki and R. Maruyama. Tohoku Univ. Grad. Sch.of Med. and Tohoku Univ. Hosp., Japan.D213 644.4 Quantifi cation of hemodynamics in murinemyocardium following manganese infusion. C. Constantinides,S. Angeli and R. Mean. Univ. of Cyprus.D214 644.5 CD36 and interacting stresses in cardiomyopathy.L.K. M. Steinbusch, J. Luiken, R. Vlasblom, A. Chabowski,N. Hoebers, W. Coumans, I. Vroegrijk, P. Voshol, M. Ouwens,J. Glatz and M. Diamant. Cardiovasc. Res. Inst. Maastricht,Netherlands, Free Univ. Med. Ctr., Amsterdam, Med. Univ. ofBialystock, Poland, Leiden Univ. Med. Ctr., Netherlands, Univ.of Cambridge and German Diabetes Ctr., Düsseldorf.D215 644.6 The effect of COX inhibition on augmentationindex and peripheral wave refl ection. C. Hines, J-R.A.Shepherd, W.T. Nicholson, D.P. Casey, J.E. Schmidt, M.J.Joyner and J.N. Barnes. Mayo Clin.D216 644.7 Dual recordings of left ventricular and arterialpressure in conscious rats via telemetry. D. McCormick, S-J.Guild, M. Lim, B. Pauly, R. Kirton, D. Budgett, C.J. Barrett,M. Kondo, E. Stehlin and S.C. Malpas. Telemetry Res.Ltd., Auckland, Univ. of Auckland and Millar Instruments Inc.,Houston.D217 644.8 End systolic pressure change following acuteisometric exercise. P. Sun, A.D. Lane, S. Ranadive, H. Yan,R.M. Kappus, M.D. Cook, G.V. Mendonça and B. Fernhall.Univ. of Illinois at Urbana-Champaign, East China NormalUniv., Shanghai and Tech. Univ. of Lisbon.D218 644.9 Effects of dysbacteriosis on gastrointestinalhormones of rats. L. Yang, X. Hao, X. Hu, Y. Kang and G.Zhang. Jiamusi Univ. and Xinan Jiaotong Univ., People’sRepublic of China.D219 644.<strong>10</strong> A novel approach to noninvasive measurementof cardiac output. M. Klein, M. Machina, A. Battisti, O. Pucci,L. Minkovich, J. Duffin and J. Fisher. Univ. of Toronto andThornhill Res. Inc., Toronto.D220 644.11 Gender affects blood pressure, but not wastedleft ventricular effort following maximal exercise A.D. Lane, H.Yan, S.M. Ranadive, R.M. Kappus, G. Hall, I.S. Harvey, K.Wilund, J. Woods and B. Fernhall. Univ. of Illinois at Urbana-Champaign.D221 644.12 Parallel stiffening and remodeling of the agingheart and aorta. L.L. Cooper, K.E. Odening, O. Ziv, L. Chaves,L. Schofield, A. Gemignani, G.F. Mitchell and G. Koren.Brown Univ., Rhode Island Hosp., Warren Alpert Med. Sch. ofBrown Univ. and Cardiovasc. Engin. Inc., Norwood, MA.192
<strong>SUNDAY</strong>D222 644.13 Effect of blood volume change on circulationand heart rate variability during autologous blood donation. M.Kamakura, M. Haga, M. Nagai and H. Chiba. Tohoku Univ.Grad. Sch. of Med., Japan.D223 644.14 Intracellular Na + homeostasis in diabeticmammalian cardiomyocytes. B. Turan, A. Bilginoglu and H.B.Kandilci. Ankara Univ.D224 644.15 Chronic exposure to diesel exhaust particulatesinduces cardiac remodeling and dysfunction. J.M. Bradley andJ. Gardner. LSU Hlth. Sci. Ctr., New Orleans.D225 644.16 Beta-adrenergic stimulation causes rapidNOS1-dependent S-nitrosylation of cardiac proteins, associatedwith increased contractility M.P. Boric, A. Vielma and D.R.González. Pontifi cal Catholic Univ. of Chile and Univ. de Talca,Chile.D226 644.17 Continuous and less invasive cardiac outputmonitoring by long time interval analysis of a peripheral arterialblood pressure waveform with pulse transit time correction. G.Zhang, M. Moslehpour and R. Mukkamala. Michigan StateUniv.D227 644.18 Altered mitochondrial protein levels afterchronic ethanol consumption in the aged estrogen defi cientrat heart. J.L. Miller-Lee, D.R. Sharda, G.M. Kanski, N.J.Tomicek, J.C. Hunter and D.H. Korzick. Penn State.D228 644.19 Cardiovascular effects of levosimendan duringrewarming from severe hypothermia in vivo. B. Haaheim, E.S.Dietrichs, T. Tveita and G. Sieck. Univ. of Tromsø, Norway andMayo Clin.D229 644.20 Evaluation of cardiac function in hypertensioninduced by salt intake. V. Farah, P. Fiorino, L. Souza-Teodoro,R. Sirvente, C. Mostarda, I.C. Araujo, M.C. Fonteles andM.C. Irigoyen. Mackenzie Presbyterian Univ., Brazil and Med.Sch., Heart Inst., Univ. of São Paulo.D230 644.21 Perinatal infl ammation causes adult cardiacdiseases: a novel model for fetal origins of adult diseases. M.Velten, K.R. Hutchinson, M.W. Gorr, C. Velten, L.E. Wold, P.A.Lucchesi and L.K. Rogers. Res. Inst. at Nationwide Children’sHosp.D231 644.22 Body weight loss as an independent markerof acute heart failure after myocardial infarction in rats. I.Stefanon, T. Faria, M. Baldo, M.R. Simões, R. Pereira andD.V. Vassallo. Fed. Univ. of Espírito Santo, Brazil.D232 644.23 Akt2 knockout alleviates high-fat diet-inducedcardiac dysfunction. X. Xu, Y. Hua, Y. Zhang and J. Ren.Univ. of Wyoming and Xijing Hosp., Fourth Military Med. Univ.,People’s Republic of China.D233 644.24 iNOS inhibition causes myocardial abnormalitiesthrough an AKT-dependent pathway. N. Roe and J. Ren. Univ.of Wyoming.D234 644.25 Cardiac hypertrophy adaptations to irondefi ciency transition from adaptive to pathological and correlatewith sympathetic nervous system activation. H.G. Chew, B.Almaw, A. Boynton, K. Dockter, M. Arcadia, A. Grasmick, S.Slaugh and A. Robinson. Western Wyoming Col.D235 644.26 Pathologic cardiac hypertrophy, but notphysiologic cardiac growth, induces O-GlcNAc signaling R.E.Brainard, G.A. Ngoh, H.T. Facundo, P.M. Stoller and S.P.Jones. Univ. of Louisville.D236 644.27 Cardiovascular responses to deep inhibitory ribraising osteopathic manipulation in healthy young individuals.M. Ioudina and E. Toder. Touro Univ. Nevada Col. of Osteo.Med.D237 644.28 Cardiac function is diminished in diet-inducedobese mice. A.K. Reddy, C.J. Hartley and G.E. Taffet. BaylorCol. of Med.D238 644.29 EGFR tyrosine kinase inhibitor tyrphostinAG-1478 causes moderate hypomagnesemia and cardiacdysfunction. I.T. Mak, J.H. Kramer, J.J. Chmielinska, C.F.Spurney and W.B. Weglicki. George Washington Univ. andChildren’s Natl. Med. Ctr.645. NEURAL CONTROL OF CARDIOVASCULARFUNCTIONPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-3:00 PMPHYSIOLOGYD239 645.1 Enhanced nitric oxide-mediated blunting ofsympathetic vasoconstriction following 4 weeks of exercisetraining. N.G. Jendzjowsky and D.S. DeLorey. Univ. ofAlberta.D240 645.2 Artifi cial barorefl ex system restores volumebuffering function in the barorefl ex failure irrespective of leftventricular systolic function. K. Hosokawa, K. Funakoshi, A.Tanaka, T. Sakamoto, K. Onitsuka, K. Sakamoto, T. Tobushi,T. Fujino, T. Ide and K. Sunagawa. Kyushu Univ. Grad. Sch. ofMed. Sci., Japan.D241 645.3 Serotonin-induced hypotension is not due toa reduction in preganglionic splanchnic sympathetic nerveactivity in the Sprague Dawley rat. R.P. Davis, H.S. Orer, S.M.Barman and S.W. Watts. Michigan State Univ. and HacettepeUniv., Turkey.D242 645.4 Blockade of parasympathetic regulation of theheart induces depressive behaviors. M.L. Scotti, S.L. Bates,J. Wardwell, N. McNeal, D.L. Chandler and A.J. Grippo.Northern Illinois Univ.D243 645.5 Hypocretin-1 (orexin A) enhances theGABAergic pathway from the lateral paragigantocellularnucleus to cardiac vagal neurons in the nucleus ambiguus. O.Dergacheva and D. Mendelowitz. George Washington Univ.D244 645.6 Postsynaptic integration in rat sympatheticneurons follows three cellular profi les. M.G. Springer and J.P.Horn. Univ. of Pittsburgh.D245 645.7 Chronotropic effect of stimulation of α1adrenergic receptors in mouse atria. Y-F. Li, M. Grandi and J.Freeling. Univ. of South Dakota.D246 645.8 Activation of NMDA receptors in the medialprefrontal cortex attenuates the cardiovascular responseto acute stress. F.C. Müller-Ribeiro, D.V. Zaretsky, M.V.Zaretskaia, J.A. DiMicco and M.P. Fontes. Fed. Univ. of MinasGerais, Brazil and Indiana Univ. Sch. of Med.D247 645.9 Intracerebroventricular microinjection ofliposome-entrapped GABA reduces cardiac reactivity to acutestress and anxiety-like behaviour. G.C. Vaz, A.C. Carvalho, C.H.Xavier, A.P. Bahia, R.A. S. Santos, F.A. Moreira, F.J. Frezardand M.A. P. Fontes. Fed. Univ. of Minas Gerais, Brazil.D248 645.<strong>10</strong> Pilot investigation of the cardiopulmonarybarorefl ex control of ventricular contractility. R. Mukkamala,J.A. Sala-Mercado, X. Chen, R.L. Hammond, M. Ichinoseand D.S. O’Leary. Michigan State Univ. and Wayne State Univ.Sch. of Med.SUN193
PHYSIOLOGYD249 645.11 Effects of aging on cardiac autonomic controlin female rats – role of physical training. G. C.S. V. Tezini, J.M.Porto and H. C.D. Souza. Sch. of Med. of Ribeirão Preto, Univ.of São Paulo.D250 645.12 Regulation of store operated calcium channelsby μ-opioid receptor activation in mammalian intracardiacneurons. T. Bonds and J. Cuevas. Univ. of South Florida.D251 645.13 Postsynaptic crosstalk between excitatory(NMDA) and inhibitory (GABAA) receptors in neurosecretoryneurons of the hypothalamic supraoptic nucleus. E. Potapenko,V.C. Biancardi, R.M. Florschutz and J.E. Stern. Med. Col. ofGeorgia.D252 645.14 Nucleus ambiguus neurons are activated byacupuncture: relation to acetylcholine and enkephalin. Z-L.Guo and J.C. Longhurst. Univ. of California, Irvine.D253 645.15 Age-related decreases in barorefl ex sensitivityand circadian variation of blood pressure and heart rate aremediated by centrally produced hydrogen peroxide. B. Erdos,H. Frimpong, M.A. Whidden, N. Kirichenko and N. Tumer. VAMed. Ctr. and Univ. of Florida.D254 645.16 Effects of Bacillus anthracis lethal and edematoxins on functional indices of sympathetic nerve dischargeregulation. A.A. Garcia, R.J. Fels and M.J. Kenney. KansasState Univ.D255 645.17 Parasymapthetic and sympathetic contributionsto enhanced cardiac barorefl ex gain after exposure to chronicintermittent hypoxia in rats. A.Q. Silva and A.M. Schreihofer.Univ. of North Texas Hlth. Sci. Ctr.646. NEURAL MECHANISMS IN CARDIOVASCULARDISEASEPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-3:00 PMD256 646.1 Brain-derived neurotrophic factor directlymodulates cardiac ventricular myocyte function. N. Feng, S.Huke, S. Shi, A. Takeshi, N. Kaludercic, G. Tomaselli, D.Bers and N. Paolocci. Johns Hopkins Sch. of Med., VanderbiltUniv. and Univ. of California, Davis.D257 646.2 Substance P receptor blockade attenuatesoxidative stress, endotoxemia and cardiac dysfunction in Mgdeficient rats. J.H. Kramer, C.F. Spurney, I-T. Mak, M. Iantorno,A. Komarov and W.B. Weglicki. George Washington Univ. andChildren’s Natl. Med. Ctr.D258 646.3 After myocardial infarction, rats displayneophobia and altered forebrain metabolic activation inresponse to locus coeruleus stimulation J. Glasgow, A.Samarel, Y. Koshman, D. Klein and K. Scrogin. Loyola Univ.Chicago, Maywood.D259 646.4 Effect of statin therapy on resting sympatheticnerve activity and oxidative stress in patients with heart failure.S.H. Deo, L.C. Vianna, A. Kim, A. Chockalingam, M.C.Zimmerman, I.H. Zucker and P.J. Fadel. Univ. of Missouri-Columbia and Univ. of Nebraska Med. Ctr.D260 646.5 Cardiac spinal deafferentation reduces thesusceptibility to sustained ventricular tachycardia in consciousrats by reducing cardiac metabolic demand. H.L. Lujan, S.Krishnan and S.E. DiCarlo. Wayne State Univ. Sch. of Med.D261 646.6 Role for the medial amygdala in mediatinghypertenion in a neurogenic mouse model. P. Davern, K.Jackson, T-P. Nguyen-Huu and G. Head. Baker IDI Heart &Diabetes Inst., Melbourne.D262 646.7 Involvement of the autonomic nervous systemin cardiovascular function of monosodium glutamate-inducedobese rats. M. Karlen-Amarante, N.V. Cunha, O. Andradeand M.C. Martins-Pinge. State Univ. of Londrina, Brazil.D263 646.8 Hindlimb unloading results in an increasedpredisposition to cardiac arrhythmias and changes in leftventricular connexin43 expression. J.A. Moffitt, K.C. Welliver,A.J. Jepson and M.K. Henry. Des Moines Univ.D264 646.9 Epithelial sodium channels contribute to theblunted sensitivity of aortic baroreceptors in chronic heartfailure rats. H. Tu, T. Thai, R. Muelleman and Y-L. Li. Univ. ofNebraska Med. Ctr.D265 646.<strong>10</strong> Effect of pyridostigmine on both cardiac functionand remodeling in heart failure rats. R.M. Lataro, C.A. A. Silva,C.M. Prado, M.A. Rossi, R. Fazan, Jr. and H.C. Salgado. Sch.of Med. of Ribeirão Preto, Univ. of São Paulo.D266 646.11 Increased acetylcholine availability in the earlystages of heart failure in rats: effects on cardiac autonomic toneand left ventricular function. D.P. M. Dias, R. Fazan, Jr., H.C.Salgado, T. Beltz and A.K. Johnson. Sch. of Med. of RibeirãoPreto, Univ. of São Paulo and Univ. of Iowa.D267 646.12 Chronic electrical stimulation of the ventrallateral periaqueductal grey evokes a persistent and substantialhypotensive response in spontaneously hypertensive but notnormotensive rats. F.D. McBryde, N. Patel and J.F. R. Paton.Univ. of Bristol and Frenchay Hosp., Bristol.D268 646.13 Distribution and morphology of CGRP- andSP-IR (immunoreactive) axons in the whole-mount atria of FVBmice. L. Li, J. Hatcher, H. Gu and Z. Cheng. Univ. of CentralFlorida Col. of Med. and Univ. of Iowa Col. of Med.D269 646.14 Control of cardiac chronotropy by the nucleusambiguus and dorsal motor nucleus of the vagus: a lighthand on the cardiac tiller. L. Salo, R. McAllen, M. Ambler, S.Kasparov, J.F. R. Paton and T. Pickering. Univ. of Bristol andHoward Florey Inst., Melbourne.647. NEURAL CONTROL IN HUMANSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-3:00 PM<strong>SUNDAY</strong>D270 647.1 Pressor responses following a spontaneousburst of muscle sympathetic nerve activity: infl uence of ageand sex. L.C. Vianna, E.C. Hart, S.T. Fairfax, N. Charkoudian,M.J. Joyner and P.J. Fadel. Univ. of Missouri-Columbia andMayo Clin.D271 647.2 Sex-related differences in fi ring patterns ofintegrated muscle sympathetic nerve activity in humans. H.Yang, W.H. Cooke, K.S. Reed and J.R. Carter. MichiganTechnol. Univ. and Univ. of Texas at San Antonio.D272 647.3 Estrogen enhances barorefl ex sensitivityin women with low orthostatic tolerance. M.M. Wenner, H.S.Taylor, A.S. Haddadin and N.S. Stachenfeld. John B. PierceLab., New Haven and Yale Univ. Sch. of Med.194
<strong>SUNDAY</strong>D273 647.4 Infl uence of sex on carotid barorefl ex controlof muscle sympathetic nerve activity during hypo- andhypertensive stimuli in humans. A. Kim, J.P. Fisher and P.J.Fadel. Univ. of Missouri-Columbia andSch. Of Sport & Exer.Sci., Univ. of Birmingham.D274 647.5 Muscle sympathetic nerve activity atpresyncope: infl uence of tolerance to central hypovolemia.K.L. Ryan, C.A. Rickards, C. Hinojosa-Laborde, W.H. Cookeand V.A. Convertino. U.S. Army Inst. of Surg. Res., Fort SamHouston and Univ. of Texas at San Antonio.D275 647.6 Heart period variability responses duringsimulated hemorrhage in high and low tolerant subjects.C. Hinojosa-Laborde, C.A. Rickards, K.L. Ryan and V.A.Convertino. U.S. Army Inst. of Surg. Res., Fort Sam Houstonand Univ. of Texas at San Antonio.D276 647.7 Is barorefl ex function an adequate predictor oforthostatic tolerance? D. Leone, S. Jarvis and J. Pawelczyk.Penn State.D277 647.8 Carotid barorefl ex mediated reductions in heartrate and resting heart rate variability in African Americans. D.Keller and S. Holwerda. Univ. of Texas at Arlington.D278 647.9 Infl uence of omega-3 fatty acids onneurovascular responses to mental stress in normotensivehumans. C.E. Schwartz, M.J. Joyner, J.J. Durocher and J.R.Carter. Michigan Technol. Univ. and Mayo Clin.D279 647.<strong>10</strong> Chronic stress impairs cardiac autonomicmodulation in patients with metabolic syndrome. E. Toschi-Dias, I.C. Trombetta, V.J. Dias da Silva, C. Maki-Nunes,M. J.N. Alves, R.F. Fraga, L.F. Angelo, D.G. Martinez, C.E.Negrao and M. U.P. B. Rondon. Univ. of São Paulo Med. Sch.,Sch. of Med., Fed. Univ. of Triangulo Mineiro, Brazil and Sch. ofPhys. Educ. and Sport, Univ. of São Paulo.D280 647.11 Long-range correlation of muscle sympatheticnerve activity and arterial blood pressure in older humans.J.P. Fisher, J.H. Coote, P.J. Fadel and T. Zhang. Univ. ofBirmingham, U.K., Univ. of Missouri-Columbia and NankaiUniv., People’s Republic of China.D281 647.12 Assessing sympathetic vascular transduction inhumans: beat-to-beat considerations. S.T. Fairfax, L.C. Vianna,M.J. Davis and P.J. Fadel. Univ. of Missouri-Columbia.D282 647.13 Effects of volume and rate of saline infusion intoan occluded limb on sympathetic activation. J. Cui, C. Blaha, J.Pollock, J. Mast, U.A. Leuenberger and L.I. Sinoway. PennState Col. of Med.D283 647.14 Acute alcohol ingestion lengthens sympatheticburst latency in humans. J.J. Durocher, R.A. Larson and J.R.Carter. Michigan Technol. Univ.D284 647.15 Exercise training restores cardiac andperipheral sympathetic activity and barorefl ex sensitivity afteracute myocardial infarction. D.G. Martinez, E. Toschi-Dias,J.C. Nicolau, R. Lage, I.C. Trombetta, L. Matos, M.J. N. Alves,V.J. Dias da Silva, C.E. Negrao and M.U. P. B. Rondon. Univ.of São Paulo Med. Sch., Sch. of Med., Fed. Univ. of TrianguloMineiro, Brazil and Sch. of Phys. Educ. and Sport, Univ. of SãoPaulo.D285 647.16 Acupuncture attenuates exercise-inducedincreases in skin sympathetic nerve activity. K. Toma, S.Walkowski, K. Metzler-Wilson and T.E. Wilson. Ohio Univ.Col. of Osteo. Med.D286 647.17 Cerebral blood fl ow regulation: role of otolithinputs. M.J. Falvo, M. Blatt, J. Jaisen, R. Miller, S.J. Wood andJ.M. Serrador. VA New Jersey Hlth. Care Syst., East Orange,NASA Johnson Space Ctr. and Harvard Med. Sch.D287 647.18 Noninvasive assessment of cardiovascularautonomic neuropathy. S. Wang, D.C. Randall, C.F. Knapp,K.R. Nelson, A.R. Patwardhan and J.M. Evans. Univ. ofKentucky.D288 647.19 Facial skin blood fl ow response to pleasant andunpleasant taste stimuli. H. Kashima and N. Hayashi. KyushuUniv., Japan.648. NEURAL CONTROL OF VISCERAL ANDMETABOLIC FUNCTIONPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-3:00 PMPHYSIOLOGYD289 648.1 Role of catecholaminergic neurons in theregulation of thermogenesis in brown adipose tissue. C.Madden. Oregon Hlth. & Sci. Univ.D290 648.2 Neuropeptide Y in rostral raphe pallidusactivates brown adipose thermogenesis. S.F. Morrison, J.M.Igoe, D. Cleary and M. Heinricher. Oregon Hlth. & Sci. Univ.D291 648.3 Inhibition of median preoptic area neuronsinhibits brown adipose tissue sympathetic outfl ow. D. Tuponeand S.F. Morrison. Oregon Hlth. & Sci. Univ.D292 648.4 Organization of metabotropic glutamatereceptors on pancreas-projecting DMV neurons. T. Babic, K.Browning and R.A. Travagli. Penn State Col. of Med.D293 648.5 Streptozotocin-induced activation of group IImetabotropic glutamate receptors in the dorsal motor nucleusof the vagus. T. Babic, R.A. Travagli and K. Browning. PennState Col. of Med.D294 648.6 Metabolic effects of deoxycorticosterone-saltrequire the brain renin-angiotensin system. J.L. Grobe, B.A.Buehrer, A.M. Hilzendeger, X. Liu, D.R. Davis and C.D.Sigmund. Univ. of Iowa.D295 648.7 Extensive glucagon-like peptide 1 innervationof autonomic control regions in the brain. I.J. Llewellyn-Smith,F. Reimann, F. Gribble and S. Trapp. Flinders Univ., Australia,Cambridge Univ. and Imperial Col. London.D296 648.8 Signaling pathways regulating BDNFexpression in lumbosacral dorsal root ganglia during bladderinfl ammation. S.J. Yu and L-Y. Qiao. Virginia CommonwealthUniv.D297 648.9 Involvement of metabotropic glutamatereceptor mGlu5 in pudendal inhibition of bladder overactivity incats. J. Larson, B. Shen, J. Wang, J. Roppolo, W.C. Degroatand C. Tai. Univ. of Pittsburgh.D298 648.<strong>10</strong> Neural control of bladder in the decerebrate,arterially-perfused whole rat preparation P. Sadananda, M.Drake, J.F. R. Paton and T. Pickering. Univ. of Bristol andBristol. Urol. Inst.D299 648.11 Decreased sensitivity to the excitatory effect ofphenylephrine, an α1 adrenergic receptor agonist, in the raturinary bladder during postnatal development. S.L. Daugherty,K. Koronowski, J. Volpe, A. Hohenadel, A. King and W.C. deGroat. Univ. of Pittsburgh.D300 648.12 Sex differences of neonatal bladder phasiccontractile activity. S.L. Daugherty, W.C. de Groat, K.Koronowski, J. Volpe, A. Hohenadel, D.E. Artim and H-Y.Wu. Univ. of Pittsburgh and Stanford Univ.SUN195
PHYSIOLOGY649. FORWARD GENETIC ANALYSIS OF NEURONSSYSTEM DEVELOPMENT AND FUNCTION(POSTERS)PosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-3:00 PMD301 649.1 miR-223 regulates immature neuronsexcitability and dendritic development. M. Harraz, S. Eacker, T.Dawson and V. Dawson. Johns Hopkins Univ. Sch. of Med.D302 649.2 Lack of heterotrimeric G protein beta 5 impairsbrain development and neurologic function in mice. J. Zhang,M. Pandey, L.M. Panicker, E.M. Seigneur, L. Koo, O.M.Schwartz, C-K.J. Chen and W.F. Simonds. NIDDK and NIAID,NIH and Virginia Commonwealth Univ.D303 649.3 The effects of maternal infl ammation on thesex-typical development of social and motor behaviors and thearchitecture of prefrontal and striatal neurons in peri-pupertalrats. C. Mitchell, E.F. Field, A.A. Kentner, S.A. McLeod, B.Kolb and Q.J. Pittman. Mount Royal Univ., Univ. of Calgary,Univ. of Alberta and Univ. of Lethbridge, Canada.650. CNS BLOOD BRAIN BARRIER, ISCHEMIA,NEUROINFLAMMATION, NEUROPROTECTIONPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-3:00 PMD304 650.1 Injury severity profi le of penetrating ballisticlikebrain injury in rats on neurofunctional outcome, blood-brainbarrier permeability, and brain edema formation D.A. Shear, R.Pedersen, A. Davis, G. Wei, Z. Chen, C. Yao, J. Dave, X-C.M.Lu and F.C. Tortella. Walter Reed Army Inst. of Res.D305 650.2 Hyperglycemia stimulates blood-brain barrierendothelial cell Na-K-Cl cotransporter and Na/H exchangeactivities and induces cerebral edema in the rat. N.Y-y. Yuen,B.K. Wallace, A. Trifu, N. Glaser, S.E. Anderson and M.E.O’Donnell. Univ. of California, Davis and Sacramento.D306 650.3 Activating blood-brain barrier PKCβ1 reversesin vitro and in vivo induction of P-glycoprotein by dioxin. D.S.Miller, B.T. Hawkins and X. Wang. NIEHS, NIH, ResearchTriangle Park.D307 650.4 Inorganic phosphate (Pi) transport by rat Z3<strong>10</strong>choroid plexus epithelial cells suggests involvement of type IIINa + - Pi cotransporters (PiT1/2, slc20A1/2). A.M. Bataille, S.L.Parker and J.L. Renfro. Univ. of Connecticut.D308 650.5 Nesfatin-1 does not infl uence intracellularconcentrations in subfornical organ neurons. C. DeVille and A.Ferguson. Queens Univ., Canada.D309 650.6 Effect of a CXCR2 antagonist on CXCL1,CXCL2 and CXCR2 brain expression and infarct volume afterstroke in C57BL6 mice C. Sobey, V. Brait, J. Rivera, S. Lee, B.Broughton and G. Drummond. Monash Univ., Australia.D3<strong>10</strong> 650.7 Hydrogen sulfi de ameliorates mitochondrialMMP-9 mediated mitochondria remodeling in cerebralischemia. N. Tyagi, N. Qipshidze, C. Munjal, N. Metreveli, A.Dankowski, P.K. Mishra, U. Sen, D. Lominadze, S. Givvimaniand S.C. Tyagi. Univ. of Louisville.<strong>SUNDAY</strong>D311 650.8 Dipropionylcysteine ethyl ester treatmentimproved recovery after transient focal cerebral ischemia in rat.K. Xu, Y. Kuang, P. Huang, J.C. LaManna and M.A. Puchwicz.Case Western Reserve Univ.D312 650.9 Dynamics of mitochondrial fi ssion and fusionin neuronal cell culture following oxygen-glucose deprivation.E.A. Wappler, S.A. James, P.V. G. Katakam and D.W. Busija.Wake Forest Univ. Hlth. Sci.D313 650.<strong>10</strong> Angiotensin(1-7) increases survival of strokepronespontaneously hypertensive rats. R.W. Regenhardt, P.Ritucci-Chinni, F. Desland, A.P. Mecca and C. Sumners.Univ. of Florida.D314 650.11 Cold enhances neuroprotection in hippocampalslices from hibernating Syrian hamsters. C.J. Lewis, A.D.Manis, G.H. Liepart, J.S. Hamilton, J.M. Horowitz and B.Horwitz. Univ. of California, Davis.D315 650.12 MiR-223 is neuroprotective by targeting theglutamate receptor. M. Harraz, S. Eacker, T. Dawson and V.Dawson. Johns Hopkins Univ. Sch. of Med.D316 650.13 High doses of pyruvate and lactate protectcultured cortical neural cells against ionizing radiation-inducedcellular damage. G. Xing and R. Bunger. Uniformed Svcs.Univ. of Hlth. Sci.D317 650.14 The angiotensin II AT 1receptor blockadeinhibits the lipopolysaccharide-induced infl ammatory responsein the nucleus tractus solitarii. E. Sanchez-Lemus, J. Benickyand J.M. Saavedra. NIMH, NIH.D318 650.15 Increased neuroinfl ammatory and arachidonicacid cascade markers with synaptic marker loss inlipopolysaccharide infused rats. M. Kellom, M. Basselin, M.Chen, S.I. Rapoport and J.S. Rao. NIA, NIH.D319 650.16 Angiotensin II AT1 receptor blockadeameliorates the response of brain to the systemic immunechallenge. J. Benicky, E. Sanchez-Lemus, M. Honda, J.Wang, M. Orecna and J.M. Saavedra. NIMH, NIH.D320 650.17 The melanocortin receptor system: an antiinflammatory therapeutic target for stroke. F.N. Gavins,P.M. Holloway and S. Getting. Imperial Col. London andWestminster Univ., U.K.D321 650.18 Stretch-induced ATP release from optic nerveastrocytes. A.J. Argall, J.M. Beckel, J.C. Lim, M. Shahidullah,E.J. Macarak, A.M. Laties, N.A. Delamere and C.H. Mitchell.Univ. of Pennsylvania and Univ. of Arizona.D322 650.19 Methodology for automated stereotacticdelivery of viral vectors to brain-specifi c regions in mice. J.A.Bonds, Y. Hu, H. Hosalkar, H.H. Patel, P.M. Patel and B.P.Head. UCSD.D323 650.20 Cannabinoids prevent TLR2-inducedinfl ammation in human glioma cells. R. Echigo, N. Sugimoto,A. Yachie and T. Ohono-Shosaku. Kanazawa Univ., Japan.D324 650.21 Secondary mechanical hyperalgesia isreduced by interferential current stimulation in arthritic rats. V.J.Santana-Filho, A.M. Araújo, A. C.S. Santos, L.J. Quintans,Jr., L.R. Bonjardim and J.M. DeSantana. Fed. Univ. of Sergipe,Brazil.196
<strong>SUNDAY</strong>651. CNS NEURONAL EXCITABILITY, SYNAPTICTRANSMISSION AND NEUROPLASTICITYPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-3:00 PMD325 651.1 TNFα enhances TASK3 potassium channelcurrent in a model of infl ammation. M.F. El Hachmane, V.V.Sumbayev and A. Mathie. Medway Sch. of Pharm., Univ. ofKent, U.K.D326 651.2 Regulation of NBCe1-A and NBCe1-B in mousehippocampal neurons in vitro. O.O. Oehlke, H.W. Martin andE. Roussa. Univ. of Freiburg, Germany.D327 651.3 GLT-1 over-expression attenuates bladdernociception and cross-organ sensitization. K. Roman, M. Yangand R.L. Stephens. Ohio State Univ. and Third Military Med.Univ., People’s Republic of China.D328 651.4 C2 hemisection shifts the balance of KCC2 andNKCC1 expression in phrenic motoneurons. F. Ben Mabrouk,S. Vinit and G. Mitchell. Univ. of Wisconsin-MAdison Sch. ofVet. Med.D329 651.5 Neuron-targeted caveolin-1 enhances prosurvivalsignaling, dendritic growth and axonal sprouting B.P.Head, Y. Hu, D.M. Roth, H.H. Patel and P.M. Patel. VA Med.Ctr. and UCSD.D330 651.6 G-protein coupled receptors shape neuronalactivity and synaptic transmission of olfactory bulb interneurons.H. Du, Z-J. Wang and T. Heinbockel. Howard Univ. Col. ofMed.D331 651.7 Chronic α 1Aadrenergic receptor stimulationincreases lifespan in mice. K.M. Collette, C. Hurtt, D. Perezand V. Doze. Univ. of North Dakota Sch. of Med. and Hlth. Sci.and Cleveland Clin. Fndn.D332 651.8 Neuronal uptake of nanoformulated copper/zinc superoxide dismutase via clathrin-mediated endocytosis.E.G. Rosenbaugh, D.S. Manickam, E.V. Batrakova, A.V.Kabanov and M.C. Zimmerman. Univ. of Nebraksa Med. Ctr.D333 651.9 Phosphoinositide 3-kinase and mitogenactivated protein kinase signaling in the paraventricularnucleus in renal wrap hypertension. M.E. MacDonald and C.A.Northcott. Michigan State Univ.D334 651.<strong>10</strong> Exposure to intermittent hypoxia for 7 daysincreases dissolved oxygen in the hypothalamic paraventricularnucleus. G.M. Toney, M. Herrera-Rosales and M.A. Andrade.Univ. of Texas Hlth. Sci. Ctr. at San Antonio.D335 651.11 Activation of central angiotensin type 2receptors by compound 21 suppresses sympathetic outfl ow inrats with chronic heart failure. J. Gao, L. Xiao, J. Chao, I.H.Zucker and L. Gao. Univ. of Nebraska Med. Ctr.D336 651.12 Median preoptic nucleus and subfornical organdrive renal sympathetic nerve activity via a glutamatergicmechanism within the PVN. T.L. Llewellyn, H. Zheng, X. Liu,B. Xu and K.P. Patel. Univ. of Nebraska Med. Ctr.D337 651.13 Neuronal (pro)renin receptor stimulation ofproinfl ammatory cytokines involves NF-κB signaling. Z. Shan,G. Lamont, P. Shi, F. Lin, C. Sumners and M.K. Raizada. theUniv. of Florida.D338 651.14 Role of the raphe pallidus in mediation of thecardiovascular response to stress. C. Cockburn, K. Nowell,N.P. Le and J. Brown. James Madison Univ.D339 651.15 Benefi cial effects of endogenous andexogenous melatonin in spinal cord injured animal model. K.Park, S. Park, I. Park and Y. Hong. Inje Univ., South Korea.D340 651.16 The effects of melatonin combined withexercise on proliferation and differentiation of endogenousneural stem/progenitor cells after spinal cord injury. Y. Lee, K.Park, Y. Hong, S. Kim, S-R. Lee, E. Kim, K-T. Chang and Y.Hong. Inje Univ., South Korea and Korea Res. Inst. of Biosci.and Biotechnol., Ochang.D341 651.17 Effect of ghrelin on the regulation of dendriticspines in the rat hippocampus. J.N. Cuellar, L. Berrout and M.Isokawa. Univ. of Texas at Brownsville.D342 651.18 Insulin/IGF signaling induces distinctivepatterns of histone H3 phosphorylation in hippocampal slicecultures. X. Sun, H. Sun, H. Yao, X.Q. Gu and G.G. Haddad.UCSD and Rady Children’s Hosp. San Diego.D343 651.19 Zebrafi sh express CaMKII isoforms that areinvolved in the modulation of AMPA currents in Mauthnerneurons. D. Ali and B. Roy. Univ. of Alberta.652. CONTROL OF BREATHING: CENTRALCONNECTIVITY AND NEUROTRANSMISSIONPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-3:00 PMPHYSIOLOGYD344 652.1 Projections of the retrotrapezoid nucleus inrats. G. Bochorishvili, M. Coates, R.L. Stornetta and P.G.Guyenet. Univ. of Virginia.D345 652.2 Computational modeling of serotonin-evokedreorganization of the brain stem respiratory network. N.A.Shevtsova, A. Bischoff, Y.I. Molkov, T. Manzke, I.A. Rybakand D.W. Richter. Drexel Univ. Col. of Med., Univ. of Göttingenand DFG Res. Ctr. of Molec. Physiol. of the Brain, Göttingen.D346 652.3 Noradrenergic inputs to inspiratory hypoglossalmotoneurons in decerebrate dogs. E.A. Stuth, T. Radocaj, S.Mustapic, A.G. Stucke, F.A. Hopp and E.J. Zuperku. Med.Col. of Wisconsin, Children’s Hosp. of Wisconsin and ZablockiVA Med. Ctr.D347 652.4 Morphine-induced suppression of sighing:examining the role of endogenous opioids and general sedation.H.J. Bell, E. Azubike and V. Kehoe. Penn State Col. of Med.D348 652.5 Activating mNTS 5HT receptors eliminates theimmediate apneic response to intravenous injection of fentanylin anesthetized rats. J. Zhuang, Z. Zhang, C. Zhang and F. Xu.Lovelace Resp. Res. Inst., Albuquerque.D349 652.6 Alterations in basal respiratory timing inresponse to different durations of chronic serotonin andnorepinephrine reuptake inhibition in urethane-anesthetizedadult C57BL/6 mouse in vivo. K.A. Warren, J.M. Fu and I.C.Solomon. Stony Brook Univ.SUN197
PHYSIOLOGY653. CONTROL OF BREATHING: RESPIRATORYMOTONEURONS AND MUSCLESPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-3:00 PMD350 653.1 Neuromuscular control of the tongue duringexercise. C. Walls, C. Laine, I. Kidder, G. Berger and E.F.Bailey. Univ. of Arizona.D351 653.2 Investigating hypoglossal motor nucleusbehavior using a computational network model. H. Memelli,K.G. Horn, L.D. Wittie and I.C. Solomon. Stony Brook Univ.D352 653.3 Exploring hypoglossal motoneuron behaviorusing dynamical systems analysis. K.G. Horn, J.M. Cordovezand I.C. Solomon. Stony Brook Univ. and Univ. de los Andes,Colombia.D353 653.4 Parasternal muscle adaptation to mechanicaladvantage changes during chronic sternal torsion. A. Legrandand A. Bonaert. Univ. of Mons, Belgium.D354 653.5 Respiratory muscle conditioning intensity is agreater factor than trial duration for eliciting diaphragm fi berhypertrophy. B.K. Smith, D. Martin and P.W. Davenport. Univ.of Florida.D355 653.6 Duration of intermittent total tracheal occlusionsessions infl uences fi ber CSA in parasternal muscle fi bers.B.K. Smith, D. Martin and P.W. Davenport. Univ. of Florida.D356 653.7 Targeting phrenic motoneurons using adenoassociatedviral vectors. H.M. Argadine, L.G. Clark, Jr., W-Z.Zhan, G.C. Sieck and C.B. Mantilla. Mayo Clin.D357 653.8 Neurotrophins improve neuromusculartransmission in adult but not early postnatal diaphragm. C.B.Mantilla, L.G. Ermilov, W-Z. Zhan and G.C. Sieck. MayoClin.D358 653.9 Neuregulin 1 modulates neuromusculartransmission in diaphragm muscle during early postnataldevelopment. L.G. Ermilov, C.B. Mantilla, W-Z. Zhan andG.C. Sieck. Mayo Clin.D359 653.<strong>10</strong> Inactivity induced by cervical spinal cord injurydoes not affect diaphragm muscle fi ber size. W-Z. Zhan, C.B.Mantilla, J.N. Hurtado, Y.B. Seven and G.C. Sieck. MayoClin.D360 653.11 Ipsilateral hemidiaphragm atrophy followingunilateral cervical spinal cord injury. L.C. Gill, E.J. Gonzalez-Rothi, K-Z. Lee, K. Vandenborne, P. Reier and D. Fuller. Univ.of Florida.D361 653.12 Local spinal GABAergic mechanisms regulateexpiratory phrenic nerve activity. V. Marchenko and R.F.Rogers. Drexel Univ. Med. Col.D362 653.13 Hypocapnia increases cough motor drive anddecreases sample entropy of inspiratory and expiratory muscleelectromyograms. A. Vovk, H. Deoghare, M.J. Rose, K.F.Morris, B.G. Lindsey and D.C. Bolser. Univ. of Florida andUniv. of South Florida.654. ATPASE-DRIVEN ION PUMPSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-3:00 PMD363 654.1 Regulation of V-ATPase traffi cking in neuronsby Rab GTPases. O. Oehlke, H.W. Martin and E. Roussa.Univ. of Freiburg, Germany.D364 654.2 A novel investigation of potassium transportin breast cancer cells. S. Salyer, T. Distler, K.B. Gagnon, E.Lederer and S. Khundmiri. Univ. of Louisville and VanderbiltUniv.D365 6654.3 Proteomic analysis of ouabain-interactingproteins in human kidney cells. S. Salyer, M. Merchant, D.Wilkey, E. Lederer and S. Khundmiri. Univ. of Louisville.D366 654.4 Expression of Na,K-ATPase α1 and α2 isoformsin the skeletal muscle tissues J.A. Heiny and T. Radzyukevich.Univ. of Cincinnati.D367 654.5 Ouabain preconditioning protects rat myocardialNa/K-ATPase from ischemia/reperfusion injury. A. Belliard, Y.Sottejeau, E. Morgan and S.V. Pierre. Univ. of Toledo Col. ofMed.D368 654.6 Modulation of Na/K-ATPase surface abundanceduring ischemia/reperfusion injury in rat cardiac myocytes. Y.Sottejeau, A. Belliard and S.V. Pierre. Univ. of Toledo Hlth.Sci. Campus.655. CELL VOLUME, OSMOREGULATION ANDWATER TRANSPORTPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-3:00 PM<strong>SUNDAY</strong>D369 655.1 Inhibition of P2 receptors or phospholipaseA 2blocked regulatory volume decrease in American alligatorerythrocytes. D.B. Light, C. Wormser, S. Pore and A. Elperin.Lake Forest Col., IL.D370 655.2 Red blood cells from Python regius areinsensitive to α-hemolysin from Escherichia coli. C.K. Larsen,M. Skals, J. Leipziger, T. Wang and H.A. Praetorius. AarhusUniv., Denmark.D371 655.3 α-Haemolysin from Escherichia coli inducesshrinkage and phagocytosis of erythrocytes by THP-1monocytes. S.K. Fagerberg, M. Skals, J. Leipziger and H.A.Praetorius. Aarhus Univ., Denmark.D372 655.4 Desensitization of erythrocyte P2 receptorsreduces lysis induced by alpha-hemolysin. S.K. Fagerberg,M. Skals, J. Leipziger and H.A. Praetorius. Aarhus Univ.,Denmark.D373 655.5 Alpha-hemolysin from E. coli induces P2receptor activation, shrinkage and phosphatidyl serine exposurein human erythrocytes M. Skals, U.B. Jensen, J. Ousingsawat,K. Kunzelmann, J. Leipziger and H.A. Praetorius. AarhusUniv., Denmark and Univ. of Regensburg, Germany.D374 655.6 Complement-induced hemolysis and purinergicsignaling. J.L. Hejl, M. Skals, J. Leipziger and H.A. Praetorius.Aarhus Univ., Denmark.198
<strong>SUNDAY</strong>D375 655.7 Mechanism of high NaCl- and urea-inducedinhibition of GDPD5, an enzyme whose phosphodiesteraseactivity breaks down the osmoprotective organic osmolyteglycerophosphocholine S. Topanurak, J.D. Ferraris, J. Li, C.K.Williams and M.B. Burg. NHLBI, NIH.D376 655.8 Rac1/OSM and PLC-gamma1 contributein combination to high NaCl-induced activation of theosmoprotective transcription factor TonEBP/OREBP. X. Zhou,M.B. Burg and J.D. Ferraris. Uniformed Svcs. Univ. of Hlth.Sci. and NHLBI, NIH.D377 655.9 Evidence for participation of aquaporins duringcell volume regulation in nematocytes from acontia of Aiptasiamutabilis (Cnidaria, anthozoa) A. Marino, R. Morabito, G. LaSpada, N.C. Adragna and P.K. Lauf. Univ. of Messina, Italyand Wright State Univ.D378 655.<strong>10</strong> NFAT5 chromatin immunoprecipitation assayusing NFAT5 knockdown cells as control. Y. Izumi, N.I.Dmitrieva, J. Ferraris and M.B. Burg. NHLBI, NIH.656. INTRACELLULAR PH AND ACID-BASETRANSPORTPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-3:00 PMD379 656.1 Roles of NHE1 and NBCn1 in pH-regulationand chemotherapy resistance in MCF-7 breast cancer cellsexpressing constitutively active ErbB2. G. Lauritzen, R.Dybboe, E. Boedtkjer, C. Aalkjaer, J. Nylandsted and S.F.Pedersen. Univ. of Copenhagen, Univ. of Aarhus and DanishCancer Soc., Copenhagen.D380 656.2 Novel roles of NHE1 in motility of serumstarvedMCF7 breast cancer cells expressing constitutivelyactive ErbB2. S.F. Pedersen, G. Lauritzen, A. Gorbatenko,S.F. Lund, R. Dybboe, A. Schwab and C-M. Stock. Univ. ofCopenhagen and Univ. of Muenster.D381 656.3 Unusual transport modes of the Na + -coupledHCO 3-transporters NDCBE (SLC4A8) and NBCN2 (SLC4A<strong>10</strong>)in the absence of extracellular Cl - . M.D. Parker and W.F. Boron.Case Western Reserve Univ. Sch. of Med.D382 656.4 Role of Na-coupled HCO3 transporters inregulation of intracellular pH in rat hippocampal neuronsunder normoxic and chronic hypoxic conditions. V.A. Ruffin,P. Bouyer and W.F. Boron. Case Western Reserve Univ. andUniv. of Chicago.D383 656.5 Structural characterization of the kidney-specifi cform of the electrogenic sodium bicarbonate cotransporterNBCe1-A. N. Abuladze, I. Atanasov, K. Tsirulnikov, J. Jiang,N. Magilnick, D. Newman, Z. Zhou, A. Pushkin and I. Kurtz.UCLA.D384 656.6 Role of Ca 2+ in phosphatidylinositol4,5-bisphosphate (PIP 2)/IP 3-induced stimulation of theelectrogenic Na/bicarbonate cotransporter NBCe1-Cheterologously expressed in Xenopus laevis oocytesI.M. Thornell and M.O. Bevensee. Univ. of Alabama atBirmingham.D385 656.7 The role of carbonic anhydrase II on HCO 3--initiated transport through the SLC4A4 transporter NBCe1. F.J.Moss and W.F. Boron. Case Western Reserve Univ.D386 656.8 NBCe1 (SLC4A4) functions as a dimer andN-termini are required for unifying the transporter. M-H. Chang,H.L. Holmes and M.F. Romero. Mayo Clin. Col. of Med.D387 656.9 Distinguishing hco 3-from co 32-transport bynbce1-a. S-K. Lee, I.I. Grichtchenko and W.F. Boron. CaseWestern Reserve Univ. and Univ. of Colorado Denver, Aurora.D388 656.<strong>10</strong> Transport stoichiometry of the electrogenicsodium bicarbonate cotransporter NBCe2 estimated with anovel delta current method. X.M. Shao, L. Kao and I. Kurtz.UCLA.D389 656.11 Regulation of acidosis-induced V-ATPasetraffi cking in salivary ducts by protein phosphorylation. O.Oehlke, C. Schlosshardt and E. Roussa. Univ. of Freiburg,Germany.657. TRANSPORTERS: TRANSMITTERS,NUTRIENTS, METABOLITES AND DRUGSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-3:00 PMPHYSIOLOGYD390 657.1 PDZ-containing protein PDZD11 is associatedwith the human sodium-dependent multivitamin transporter,hSMVT in intestinal epithelial cells S.M. Nabokina, V.S.Subramanian and H.M. Said. Univ. of California, Irvine VAMed. Prog., Long Beach.D391 657.2 Roles of the putative N-glycosylation (Asn138and asn489) and PKC-phosphorylation (Ser283 and Thr286)sites of the human sodium-dependent multivitamin transporterin functionality and regulation. A. Ghosal, V.S. Subramanianand H.M. Said. Univ. of California, Irvine and VA Med. Ctr.,Long Beach.D392 657.3 Structure-function activity of the humansodium-dependent multivitamin transporter: role of histidineresidues. A. Ghosal and H.M. Said. Univ. of California, Irvine/VA Med. Ctr., Long Beach.D393 657.4 Does the HK2 cell line represent a suitablemodel for the study of drug transporter expression by renalepithelial cells? S.E. Jenkinson, E. van Loon, A. Dalzell andC. Brown. Newcastle Univ., U.K.D394 657.5 Effect of chronic alcohol consumption on biotintransport in rat kidneys. V. Subramanian, S.B. Subramanyaand H.M. Said. Univ. of California, Irvine and VA Med. Ctr.,Long Beach.D395 657.6 Characterization of serotonin transporterfunction in immortalized human lymphoblastoid cell lines. N.Hill-Kapturczak, D.M. Dougherty, D. Galindo and M. Javors.Univ. of Texas Hlth. Sci. Ctr. at San Antonio.D396 657.7 Screen of human Na+/dicarboxylatecotransporter 1 interacting proteins using the split-ubiquitinmembrane yeast two-hybrid method. J. Chung and A.M. Pajor.Skaggs Sch. of Pharm. and Pharmaceut. Sci., UCSD.D397 657.8 KCC2a expression in a primary fetal humallens epithelial cell line. V. Srivastava, P.K. Lauf, M. Di Fulvio,N.C. Adragna and N. Sharma. Wright State Univ.D398 657.9 The role of N-glycosylation in the intestinal Cl - /HCO 3-exchanger SLC26A3. H. Hayashi, Y. Yamashita and Y.Suzuki. Univ. of Shizuoka, Japan.D399 657.<strong>10</strong> Verapamil and dantrolene inhibit creatinetransport in skeletal and cardiac myocytes. J.G. Mantilla, D.O.Jacobs and L. Santacruz. Duke Univ. Med. Ctr.SUN199
PHYSIOLOGYD400 657.11 Electrogenic characteristics of the facilitativeglucose transporter GLUT12. M.P. Lostao, A. Perez, A. Reyesand J. Pujol. Univ. of Navarra, Spain and Austral Univ. ofChile.D401 657.12 Kinetics of hyperosmotically-stimulated Na-K-2Cl cotransporter in Xenopus laevis oocytes. E. Delpire andK.B. Gagnon. Vanderbilt Univ. Sch. of Med.D402 657.13 Chronic exposure of mice to genistein: sexdependenteffects. L. Al-Nakkash, J. Martin, C. Hamrick, D.Petty, S. Lynch, D. Lucy, L. Batia, A. Peterson, L. Rubin andT.L. Broderick. Midwestern Univ., AZ and Univ. of Missouri-Columbia.D403 657.14 Characteristics of uptake systems for copperdelivered to cells as copper-histidine and on plasma proteins.R. Farhad, T.Z. Kidane, E. Russo and M.C. Linder. CaliforniaState Univ., Fullerton.658. APOPTOSIS AND CELL DEATHPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-3:00 PMD404 658.1 Effects of HIV-1 gp120 and protease inhibitorson apoptotic susceptibility of CD34 + hematopoietic progenitorcells. O.J. MacEneaney, E. Connick and C.A. DeSouza. Univ.of Colorado at Boulder and Univ. of Colorado Denver, Aurora.D405 658.2 Effect of various concentrations of resveratrolon pancreatic beta-cell. C-Y. Lin, Y-T. Shen and C-c. Ni. AsiaUniv., Taiwan.D406 658.3 Chlorella protects pancreatic beta-cell fromhydrogen peroxide-induced cellular damage. C-Y. Lin, Y-Y.Lee, S-L. Chen, P-J. Huang and P-C. Chen. Asia Univ. andNatl. Chung Hsing Univ., Taiwan.D407 658.4 CB1 receptor activation induces ROSdependentand independent MAPK activation and cell deathin human endothelial cells and cardiomyocytes. R. Mohanraj,P. Mukhopadhyay, S. Bátkai, V. Patel, B. Horvath, G. Haskó,L. Liaudet, K. Mackie and P. Pacher. NIAAA, NIH, UMDNJ,Newark, Univ. of Lausanne and Indiana Univ.D408 658.5 Increased apoptosis in fi brotic lung fi broblastsunder the effects of histone deacetylase inhibitor SAHA. Y.Sanders, W. Zhang, N. Ambalavanan and J. Hagood. Univ.of Alabama at Birmingham and UCSD.D409 658.6 The effect of curcumin in transforming growthfactorβ1-induced rat lung fi brosis. Y. Cui, J. Robertson, S.Maharaj, J. Niu, J. Wang, M. Kolb and J. Gauldie. BeijingUniv. of Chinese Med. and McMaster Univ., Canada.D4<strong>10</strong> 658.7 Inhibition of MP1 expression induces apoptosisof MCF-7 breast cancer cells. M. Marina and S.E. Conrad.Michigan State Univ.D411 658.8 IRF1 promotes antiestrogen sensitivity byregulating Bik expression in breast cancer cells. R. Hu, J.Schwartz, R. Riggins and R. Clarke. Georgetown Univ.D412 658.9 Role of FLIP and CD95 in sildenafi l-inducedincreased chemosensitivity of doxorubicin in prostate cancercells. A. Das, D. Durrant, C. Mitchell, N.N. Hoke, P. Dent andR.C. Kukreja. Virginia Commonwealth Univ.D413 658.<strong>10</strong> Spatiotemporal patterning of mitosis andapoptosis during cyclic blastogenesis in a colonial protochordate.C.J. Brown and R.J. Lauzon. Union Col., NY.D414 658.11 Aging reduces in vitro thick ascending limbviability. J.X. Masjoan-Juncos, P. Dibo and G.B. Silva. J.Robert Cade Fndn. and Msgr. Carlos V. Cruvellier Fndn.,Cordoba, Argentina.D415 658.12 Surface-charge induced cellular uptake andcytotoxicity of gold nanoparticles. S. Choi, J.H. Park, S.H.Jang, H. Lee, K. Lee, P.D. Ryu, S.I. Yang, S-W. Joo and S.Y.Lee. Seoul Natl. Univ., Soongsil Univ., Yonsei Univ. and KyungHee Univ., South Korea.659. LUNG PHYSIOLOGY: AIRWAY EPITHELIALCELL BIOLOGYPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-3:00 PM<strong>SUNDAY</strong>D416 659.1 Studies on the activity of the δ-ENaCc in humanrespiratory epithelial cell lines. E. Schwagerus, S.T. Buckleyand C. Ehrhardt. Sch. of Pharm. and Pharmaceut. Sci., TrinityCol. Dublin.D417 659.2 The roles of K + channels in bronchial epithelialcells. K.M. MacLeod and E. Cowley. Dalhousie Univ.,Canada.D418 659.3 Calcium entry is restricted to basolateralmembrane SOC channels in activated human bronchialepithelial cells. C.M. Wolber, C.T. Poll and C.W. Davis. Univ.of North Carolina at Chapel Hill and Novartis Inst. for Biomed.Res., Horsham, U.K.D419 659.4 Arsenic alters P2 receptor Ca 2+ signalingassociated with innate immunity in human airway epithelialcells. C.L. Sherwood, R.C. Lantz, J.L. Burgess and S.Boitano. Univ. of Arizona.D420 659.5 A potential role of tyrosine phosphorylation inthe function of the cystic fi brosis transmembrane conductanceregulator. A.K. England, R. Muimo and L. Robson. Univ. ofSheffi eld and Royal Hallamshire Hosp., Sheffi eld.D421 659.6 Bicarbonate secretion is an essentialphysiological component of electrolyte transport in the smallairways. A.K. M. Shamsuddin and P.M. Quinton. UCSD andUniv. of California, Riverside.D422 659.7 Regulation of copper ion transporter expressionby copper and silver in A549 cells. K. Woo and C.L. Cannon.Univ. of Texas Southwestern Med. Ctr.D423 659.8 Evidence for GABA signaling in the pulmonaryneuroepithelial body microenvironment. K. Schnorbusch, R.Lembrechts, I. Pintelon, J-P. Timmermans, D. Adriaensenand I. Brouns. Univ. of Antwerp.D424 659.9 Molecular and physiological evidencefor neuroepithelial bodies as mechanotransducers in theintrapulmonary airway epithelium. R. Lembrechts, I. Brouns,K. Schnorbusch, I. Pintelon, J-P. Timmermans and D.Adriaensen. Univ. of Antwerp.D425 659.<strong>10</strong> PTEN signaling modulates lung epithelialcells migration and wound repair through changes in cellularmechanics. C. Mihai, R. Zielinski, S. Bao, D. Knoell and S.Ghadiali. Ohio State Univ.D426 659.11 Podosome formation in human bronchialepithelial cells and its signaling mechanism. M. Liu and H.Xiao. Univ. of Toronto.200
<strong>SUNDAY</strong>D427 659.12 Cigarette smoke induces macrophageinhibitory cytokine 1 to dampen innate immunity in humanairway epithelial cells. Q. Wu, D. Jiang and H.W. Chu. Natl.Jewish Hlth.D428 659.13 Interaction between cigarette smoke andcyclic AMP signaling in human bronchial epithelial function.A. Oldenburger, W. Rijks, W. Poppinga, S.S. Roscioni, I.Heijink, H. Maarsingh and M. Schmidt. Univ. of Groningenand Univ. Med. Ctr. Groningen, Netherlands.D429 659.14 Thin layer mucus dynamics in ciliated cultures.P.R. Sears, C.W. Davis, M. Chua and J.K. Sheehan. Univ. ofNorth Carolina at Chapel Hill.D430 659.15 Presence of biomolecules in airway mucusimpedes absorption of liquid across porcine tracheal epithelium.S.T. Ballard and J.L. Cooper. Univ. of South Alabama.D431 659.16 Functional effects of carbon nanotubes onairway epithelial cells. A. Banga, F.A. Witzmann and B.L.Blazer-Yost. Indiana Univ. Purdue Univ. Indianapolis andIndiana Univ. Sch. of Med.660. LUNG PHYSIOLOGY: DEVELOPMENT ANDPLASTICITYPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-3:00 PMD432 660.1 Temporal-spatial expression of alpha5nicotinic acetylcholine receptor subunits during mouse lungorganogenesis. J.L. Porter, B.R. Bukey, A.J. Geyer and P.R.Reynolds. Brigham Young Univ.D433 660.2 Vitamin D receptor deletion leads to an asthmaphenotype. V.K. Rehan, Y. Li, C. Kovacs and J. Torday. LABioMed, Torrance and Mem. Hosp. of Newfoundland, Canada.D434 660.3 VEGF family growth factor ratio is abnormal inbronchopulmonary dysplasia. S.J. Bilko, L. Xiang, L. Liu andP.G. Lloyd. Oklahoma State Univ.D435 660.4 Aspirin therapy enhances lung alveolarizationin newborn pups exposed to neonatal hyperoxia. R.D. Britt,M. Velten, L.D. Nelin and L.K. Rogers. Nationwide Children’sHosp., Columbus.D436 660.5 Newborn ovine pulmonary vascular smoothmuscle cell proliferation occurs independent of plateletactivating factor receptor activation. L.S. Renteria, J.U. Rajand B.O. Ibe. LA BioMed at Harbor-UCLA Med. Ctr. and Univ.of Illinois at Chicago.D437 660.6 Embryonic over-expression of rage in mouselung causes an imbalance between apoptosis and proliferationleading to severe lung hypoplasia. J.A. Stogsdill, M.P. Stogsdilland P.R. Reynolds. Brigham Young Univ.D438 660.7 rhCC<strong>10</strong> treatment modulates the pro- and antiinflammatory profi le in the immature lung. T. Hubert, J. Wu, Y.Park, K. Kato, K. Kimura, T. Shaffer, S. Eguchi, K.C. Kim andM.R. Wolfson. Temple Univ, and A.I. duPont Hosp. for Children,Wilmington, DE.D439 660.8 Dynamic interplay between serum responsefactor and Purβ modulates human pulmonary myofi broblastdifferentiation. S. Hariharan and A.R. Strauch. Davis Heart &Lung Res. Inst., Columbus.D440 660.9 Intrapulmonary shunt pathways are recruitedby hypoxia and beta agonists in juvenile swine. M.L. Bates, J.E.Jacobson, A.S. Sobakin, T.A. Hacker and M.W. Eldridge.Univ. of Wisconsin-Madison.D441 660.<strong>10</strong> Limit of compensatory lung growth was reachedfollowing 70% resection in adult canine lung. P. Ravikumar,D.J. Bellotto, A.S. Estrera, R.L. Johnson, Jr. and C.C. W.Hsia. Univ. of Texas Southwestern Med. Ctr.D442 660.11 Quantifying in vivo stimuli for postpneumonectomyalveolar growth: contributions from increasedperfusion and delayed lung expansion. P. Ravikumar, D.Bellotto, A.S. Estrera, R.L. Johnson, Jr. and C.C. W. Hsia.Univ. of Texas Southwestern Med. Ctr.D443 660.12 Modeling tissue changes in the aging lung usingtwo mouse strains. J. Fallica, W. Mitzner and C. Tankersley.Johns Hopkins Bloomberg Sch. of Publ. Hlth.661. MOLECULAR MECHANISMS AND GENETICSOF HYPERTENSION (POSTERS)PosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-3:00 PMPHYSIOLOGYD444 661.1 In vivo bioluminescence imaging reveals a prehypertensivesurge of nuclear factor-κB activity in the subfornicalorgan during slow-pressor angiotensin-II hypertension. C.N.Young, S.D. Butler, R.V. Sharma and R.L. Davisson. CornellUniv. and Weill Cornell Med. Col.D445 661.2 Microglial activation by the brain reninangiotensinsystem. P. Shi, J.L. Grobe, F.A. Desland, M.K.Raizada and C. Sumners. Univ. of Florida and Univ. of Iowa.D446 661.3 Transgenic expression of CGRP receptorsubunit RAMP1 in nervous system improves autonomicregulation and prevents angiotensin II hypertension. R.Sabharwal, F.M. Abboud, A.F. Russo and M.W. Chapleau.Univ. of Iowa and VA Med. Ctr.D447 661.4 Long-term induction of heme oxygenaseameliorates angiotensin II-dependent hypertension in SpragueDawley rats transduced with HO1-lentiviral construct. N. Puri,L. Vanella, K. Sodhi, J. Cao, D.H. Kim, K. Inoue, J. Quilleyand N.G. Abraham. Univ. of Toledo, Chinese PLA Gen. Hosp.,Beijing and New York Med. Col.D448 661.5 Epoxides attenuate adipogenesis in humanmesenchymal stem cells via activation of heme oxygenaseadiponectinpathways. D.H. Kim, L. Vanella, N. Puri, J.R. Falck,M.L. Schwartzman and N.G. Abraham. Univ. of Toledo, Univ.of Texas Southwestern Med. Ctr. and New York Med. Col.D449 661.6 HO-1 induction preserves ferritin functionimproving insulin sensitivity via AKT/AMPK signaling indiabetic mice. E. Foglio, K. Sodhi, N. Puri, D. Kim, L. Vanella,R. Rezzani, L.F. Rodella and N.G. Abraham. Univ. of Brescia,Italy and Univ. of Toledo.D450 661.7 HO-1 involvement in iron homeostasis in liverof obese mice. G. Favero, K. Sodhi, N. Puri, D. Kim, L. Vanella,R. Rezzani, L.F. Rodella and N.G. Abraham. Univ. of Brescia,Italy and Univ. of Toledo.D451 661.8 Delivery of endothelial progenitor cells derivedfrom consomic SS-13BN/Mcwi donor rats reduces diastolicdysfunction in hypertensive SS/MCWi recipients. S.J. Parkerand A.S. Greene. Med. Col. of Wisconsin.SUN201
PHYSIOLOGYD452 661.9 Suppression of NF-κB activity improves renalinfl ammation and renal morphology in Npr1 gene-disruptednull mutant mice. S. Das, R. Periyasamy and K.N. Pandey.Tulane Univ. Hlth. Sci. Ctr. Sch. of Med.D453 661.<strong>10</strong> Implication of cGMP cyclic nucleotidephosphodiesterases PDE1, PDE2 and PDE5 in earlyangiotensin II-induced cardiac hypertrophy in rat W. Mokni, T.Keravis, V. Schini-Kerth and C. Lugnier. Fac. of Pharm., Univ.of Strasbourg.D454 661.11 AGT is a susceptibility gene for coronary arterydisease. P.N. Muiya, S. ElHawari, E. Andres, B.F. Meyer, F.Al-Mohanna, M. Alshahid and N. Dzimiri. King Faisal Spec.Hosp. and Res. Ctr., Riyadh.D455 661.12 Cold exposure causes pulmonary hypertensionvia upregulation of phosphodiesterase 1C. P. Crosswhite andZ. Sun. Univ. of Oklahoma Hlth. Sci. Ctr.D456 661.13 Klotho gene defi ciency causes hypertensionand kidney damage. L. Bailey-Downs, X. Wang and Z. Sun.Univ. of Oklahoma Hlth. Sci. Ctr.D457 661.14 Mice lacking the circadian clock protein Per1are hypotensive. M.L. Gumz, L.R. Stow, K-Y. Cheng, I.J.Lynch, M.M. Greenlee, B.D. Cain and C.S. Wingo. Univ. ofFlorida and VA Med. Ctr.D458 661.15 Characterization of Nap5 KO rat for bloodpressure and associated phenotypes. C.P. Moreno Quinn,D.L. Mattson, A.M. Geurts, M. Dwinell, J. Lazar, R. Schilling,M. Hoffman, M. Skelton, R.J. Roman, A.W. Cowley and H.J.Jacob. Med. Col. of Wisconsin and Univ. of Mississipi Med.Ctr.662. PHYSIOLOGICAL GENOMICS OF THECARDIOVASCULAR AND RENAL SYSTEMSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-3:00 PMD459 662.1 Investigation of genes mediating the responseof human endothelial cells to steady-state laminar fl ow. M.A.Meledeo, J.A. Bynum, J.L. Sondeen, M.D. Prince and P.D.Bowman. U.S. Army Inst. of Surg. Res., Fort Sam Houston.D460 662.2 Restoration of angiogenesis phenotype innew congenic lines helps identify candidate genes for reninregulation in Dahl salt-sensitve rats. T.J. Stodola, M. Hoffman,C. Moreno-Quinn and A.S. Greene. Med. Col. of Wisconsin.D461 662.3 Rank product analysis of gene expressionin the medullary thick ascending limb of Henle of Dahl saltsensitiverats compared to salt-resistant SS.13BN consomicrats during the development of salt-sensitive hypertension. C.Yang, P. O’Connor, M. Liang and A.W. Cowley, Jr. Med. Col.of Wisconsin.D462 662.4 Narrowing of candidate region on ratchromosome 18 responsible for attenuating the developmentof hypertension in the Dahl S hypertensive rat. M. Hoffman, N.Barreto, P. Graf, J. Lazar, H.J. Jacob and C. Moreno. Med.Col. of Wisconsin.D463 662.5 Expression control of the ADAMTS16 gene bythe Wilms’ tumor transcription factor WT1. C.L. J. Jacobi, K.M.Kirschner and H. Scholz. Charité Med. Univ. Berlin.D464 662.6 Genetic analysis of mice strains with variableserum sodium concentrations identifi es the Nalcn sodiumchannel as a novel player in osmoregulation. A.P. Sinke, C.Caputo, S. Tsaih, R. Yuan, D. Ren, P. Deen and R. Korstanje.Radboud Univ. Nijmegen Med. Ctr., Netherlands, The JacksonLab., Bar Harbor, ME and Univ. of Pennsylvania.D465 662.7 Candidate genes for thrombosis susceptibilityon mouse chromosome 5. J. Hoover-Plow and R. Chao.Cleveland Clin. and Univ. of Illinois Col. of Med., Urbana.D466 662.8 Gene expression of calcium channelcomponents in Dahl salt-resistant rat mesenteric arteries byRT-PCR. A. Pena, M. Joshi and N. Tsoukias. Florida Intl.Univ.663. MICRORNAS, SIRNAS AND OTHERREGULATORY RNAPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-3:00 PM<strong>SUNDAY</strong>D467 663.1 Nebivolol alters the expression of pro-fi brosismicroRNAs in Dahl salt-sensitive rats. Y. Birnbaum, J. Qian,J.R. Perez-Polo and Y. Ye. Baylor Col. of Med., Texas HeartInst. and Univ. of Texas Med. Branch.D468 663.2 Role of microRNA-146a in regulatingmechanically induced infl ammation in human lung epithelialcells. S. Ghadiali, Y. Huang, M. Crawford and P. Nana-Sinkam. Ohio State Univ. and Ohio State Univ. Med. Ctr.D469 663.3 Slow-pressor angiotensin-II infusion increasesexpression of miR34c in subfornical organ and miR7b inparaventricular nucleus of the mouse brain. M.R. Guruju, D.J.Ho, C.L. Gorzko, Y. Zhou, R. Sharma and R.L. Davisson.Weill Cornell Med. Col. and Cornell Univ.D470 663.4 Glial cell missing 1 is reduced due toupregulation of miR30b-30d cluster in the placenta of theBPHh/5 mouse model of preeclampsia. Y. Zhou, A.K. Woods,S. Chiang, M.R. Guruju, R.V. Sharma and R.L. Davisson.Cornell Univ. and Weill Cornell Med. Col.D471 663.5 miRNA-155 regulates the human induciblenitric oxide synthase gene expression. Z. Guo, L. Shao andD.A. Geller. Univ. of Pittsburgh.D472 663.6 Role of oxidative stress via miR-199a invascular dysfunction of thoracic aorta from diabetic rats. S.S.Yildirim and B. Turan. Ankara Univ. Fac. of Med.D473 663.7 Integromic approaches to defi ne networks andbiomarkers to pathogens. R. Hammamieh, S. Muhie, S-A.Miller and M. Jett. Walter Reed Army Inst. of Res.D474 663.8 Use of the genomic library of short interferingRNA to block vascular collapse from the exposure to diversepathogenic agents. A. Gautam, R. Hammamieh, A. Filippovand M. Jett. Walter Reed Army Inst. of Res.D475 663.9 Impact of fructose consumption on geneexpression: role of miRNAs. E. Kertowidjojo, S. Krishnan, T.Hintze and C. Ojaimi. New York Med. Col.D476 663.<strong>10</strong> The RNA binding protein KSRP negativelyregulates utrophin A expression in skeletal muscle. A.Amirouche, H. Tadesse, G. Bèlanger, P. Miura, A. Coriati,J.A. Lunde, J. Côté and B.J. Jasmin. Univ. of Ottawa andSloan-Kettering Inst.202
<strong>SUNDAY</strong>D477 663.11 microRNA-301a-induced NF-κB-p50 activationmediates microRNA-130b upregulation in the failing heart. T.Hamid and S.D. Prabhu. Univ. of Louisville and Louisville VAMed. Ctr.D478 663.12 Interstitial fi brosis in the renal inner medullain humans is associated with upregulation of miR-382 anddownregulation of kallikrein 5. A.J. Kriegel, D. Mladinov, H.Kelly, P. Langenstroer, W. See and M. Liang. Med. Col. ofWisconsin.664. DIABETES (PHYSIOLOGY)PosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-3:00 PMD479 664.1 Diabetes downregulates TRPC6 proteinexpression in glomerular mesangial cells via a ROS and PKCpathway. S.M. Graham, Y. Gorin, H. Abboud, M. Ding, D.Y.Lee, Y. Ding, M. Pulse and R. Ma. Univ. of North Texas Hlth.Sci. Ctr. and Univ. of Texas Hlth. Sci. Ctr. at San Antonio.D480 664.2 Treatment with C-peptide slows the progressionof diabetic renal disease in the streptozotocin-induced diabeticrat. C. Maric, E.R. Flynn and A.R. Chade. Univ. of MississippiMed. Ctr.D481 664.3 Molecular imaging using mass spectrometryto localize renal angiotensin converting enzyme 2 activity. N.Grobe, D.R. Cool, W.C. Grunwald, Jr., K.M. Elased and M.Morris. Wright State Univ.D482 664.4 Increased mitochondrial uncoupling resultsin renal tissue hypoxia and proteinuria. M. Friederich, M.Nangaku, A. Fasching, P. Hansell and F. Palm. UppsalaUniv., Sweden and Univ. of Tokyo.D483 664.5 NADPH oxidase inhibition reduces tubular Na +transport and improves kidney oxygenation in diabetic rats. P.Persson, P. Hansell and F. Palm. Uppsala Univ., Sweden andGeorgetown Univ.D484 664.6 Time dependent regulation of nitric oxidesynthase isoforms mRNA expression in early and establishedstreptozotocin diabetes. N.G. A. Mitrou, A. Dau, N. Veldhoen,C. Helbing and W. Cupples. Simon Fraser Univ. and Univ. ofVictoria, Canada.D485 664.7 The progression of diabetes-induced renalinjury in Dahl salt-sensitive rats. J.M. Williams, A. Wells, D.Spires and R.J. Roman. Univ. of Mississippi Med. Ctr. andMurrah H.S.D486 664.8 HIF activation fails to restore renal oxygenationin already established diabetic nephropathy. F. Palm, M.Nangaku, A. Fasching, L. Nordquist and P. Hansell. UppsalaUniv., Sweden and Tokyo Univ.D487 664.9 Diabetes accelerates cystogenesis in the adultconditional ift88 knockout mouse. K.M. Sas, M.Y. Amria andP.D. Bell. Med. Univ. of South Carolina and Ralph H. JohnsonVA Med. Ctr.D488 664.<strong>10</strong> Deletion of soluble epoxide hydrolase geneimproves renal endothelial function and reduces renalinfl ammation and injury in streptozotocin-induced type 1diabetes. A.A. Elmarakby, J. Faulkner, M. Al-Shabrawey,M-H. Wang and J.D. Imig. Med. Col. of Georgia and Med. Col.of Wisconsin.D489 664.11 Proinsulin C-peptide protects against renalischemia-reperfusion injury in diabetic rats. L. Pihl, F. Palmand L. Nordquist. Uppsala Univ., Sweden.D490 664.12 Mitochondrial PKC, NAD(P)H oxidase andsuperoxide anion in the renal medullary thick ascending limbduring type 1 diabetes. J. Yang, P.H. Lane, J.S. Pollock andP.K. Carmines. Univ. of Nebraska Med. Ctr. and Med. Col. ofGeorgia.D491 664.13 Inhibition of 12-lipoxygenase reduces renalinfl ammation and damage in steptozotocin-induced diabeticmice. A.A. Elmarakby, J. Faulkner and M. Al-Shabrawey.Med. Col. of Georgia.D492 664.14 Urinary renin activity as a novel biomarkerfor diabetic nephropathy. H.A. Gevorgyan, A. Prokai, K.Villanueva and J. Peti-Peterdi. Univ. of Southern California.D493 664.15 Succinate activates the collecting duct reninangiotensinsystem. A. Prokai, J. Burford, H.A. Gevorgyan,Z. Peterfi, S.L. Vargas and J. Peti-Peterdi. Univ. of SouthernCalifornia.D494 664.16 L-Citrulline prevents progression of diabeticnephropathy by reducing arginase activity. M.J. Romero, L.Yao, A. Batta, R. Lucas, R. Caldwell, D.M. Pollock, M. Brandsand R.W. Caldwell. Med. Col. of Georgia.D495 664.17 Glomerular fi ltration at the early stage ofdiabetes. H. Nakamoto, T. Yada, Y. Ogasawara and F. Kajiya.Kawasaki Med. Sch., Japan.665. HEMODYNAMICS, GFRPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-3:00 PMPHYSIOLOGYD496 665.1 Reduced renal vascular ACE activity indiabetes. S. Xu, B.J. Bivona, D. Jin, S. Takai and L.M.Harrison-Bernard. LSU Hlth. Sci. Ctr., New Orleans, TulaneUniv. and Osaka Med. Col.D497 665.2 Mediation of renal vasoconstriction by K +channel inhibition. C.M. Sorensen, I. Giese, T.H. Braunstein,N-H. Holstein-Rathlou and M. Salomonsson. Univ. ofCopenhagen.D498 665.3 Superoxide modulates myogenic contractionsof mouse afferent arterioles. E. Lai, W.J. Welch and C.S.Wilcox. Georgetown Univ.D499 665.4 Renal microcirculatory perfusion in a pediatricmodel of sepsis-induced acute kidney injury in the rat. K.A.Seely, S.T. Burns, J.H. Holthoff, Z. Wang and P.R. Mayeux.Univ. of Arkansas for Med. Sci.D500 665.5 Increased proximal tubular uptake preventsalbuminuria in chronic endothelin-1-infused rats as determinedby intravital 2-photon microscopy. M.A. Saleh, R.M. Sandoval,G.J. Rhodes, S.B. Campos, B.A. Molitoris and D.M. Pollock.Med. Col. of Georgia and Indiana Univ., Indianapolis.D501 665.6 Inhibition of adenosine type 2 receptorsincreases fl uid uptake in the proximal tubule. C. Panico, Z. Luoand W.J. Welch. Georgetown Univ.D502 665.7 Genetic basis of altered myogenic responseand renal injury in FHH rats. M.F. Burke, M.R. Pabbidi, J.M.Williams, R. Liu, J. Lazar, H. Jacob and R.J. Roman. Univ. ofMississippi Med. Ctr. and Med. Col. of Wisconsin.SUN203
PHYSIOLOGYD503 665.8 Dynamical properties of the thick ascendinglimb: a modeling study. A. Nieves-Gonzalez, C. Clausen, H.E.Layton, A.T. Layton and L.C. Moore. Stony Brook Univ. andDuke Univ.D504 665.9 Exogenous L-arginine attenuates thevasoconstrictor response to angiotensin II stimulation inisolated rat aortic rings. S. Das and D.L. Mattson. Med. Col. ofWisconsin.D505 665.<strong>10</strong> Adenosine A1-receptors enhance renalafferent arteriole contractile responses to Ang II and L-NAME.X. Gao, A. Patzak, E.G. Persson and M. Carlstrom. UppsalaUniv. and Charité Med. Univ., Berlin.D506 665.11 Renal hemodynamic responses touninephrectomy and ischemia/reperfusion injury: impact ofexercise and rat strain. N. Moningka, M.W. Cunningham, Jr.,M. Sterling and C. Baylis. Univ. of Florida.D507 665.12 Implication of CD38 gene in podocytesepithelial to mesenchymal transition and glomerular sclerosis.K.M. Boini, M. Xia and P-L. Li. Virginia Commonwealth Univ.D508 665.13 Infl uence of high-fructose feeding on functionalα 1-adrenoceptor subtypes in the rat kidney. M.H. Abdulla, E.J.Johns, M.A. Sattar, N.A. Abdullah, M.A. H. Khan and H.A.Rathore. Univ. Sains Malaysia, University Col. Cork, Fac. ofMed., Univ. of Malaya, Malaysia and Med. Col. of Wisconsin.D509 665.14 Inorganic nitrite attenuates Ang II-mediatedcontraction of renal arterioles via xanthine oxidase-dependentgeneration of nitric oxide. M. Carlstrom, X. Gao, A. Patzak, M.Sendeski, J.O. Lundberg and E.G. Persson. Uppsala Univ.,Karolinska Inst. and Charité Med. Univ. Berlin.D5<strong>10</strong> 665.15 An implantable telemetry system for continuouschronic monitoring of kidney oxygenation in freely moving rats.D.M. Russell, E. Garry, R. Evans, G. Eppel, A. Abdelkader,A. Taberner, D. Budgett and S. Malpas. Univ. of Auckland,Blue Box Sensors Ltd., Dublin, Monash Univ., Australia, andTelemetry Res. Ltd., Auckland.D511 665.16 Nitric oxide-dependent modulation of themyogenic response in the renal circulation in eNOS- andnNOS-defi cient mice. M. Dautzenberg, G. Keilhoff and A.Just. Albert Ludwigs Univ. Freiburg and Otto von GuerickeUniv. Magdeburg.D512 665.17 The role of adenosine and ATP intubuloglomerular feedback and RBF autoregulation. M.Dautzenberg and A. Just. Albert Ludwigs Univ. Freiburg.D513 665.18 The SNARE protein VAMP2 but not VAMP3mediates cAMP-stimulated renin release from juxtaglomerularcells. M. Mendez. Henry Ford Hosp., Detroit.D514 665.19 Development of a renal collecting duct homingpeptide using phage display. P. Svenningsen and J. Peti-Peterdi. Univ. of Southern Denmark and Univ. of SouthernCalifornia.D515 665.20 Propagation of vasoconstrictive responses in amathematical model of the rat afferent arteriole. A.T. Layton,I. Sgouralis, H. Layton and L. Moore. Duke Univ. and StonyBrook Univ., SUNY.D516 665.21 Renomedullary blood fl ow and blood volumeare increased during vasopressin escape. F. Palm, P. Liss,A. Fasching, L-O. Magnusson, P. Quick, A. Persson and J.Verbalis. Uppsala Univ. and CMIV, Linköping, Sweden andGeorgetown Univ.D517 665.22 Abrogation by growth hormone of homocysteineinducedepithelial-to-mesenchymal transition through lipid raftredox signaling in podocytes. C-x. Li, M. Xia, W. Han, X-x. Li,C. Zhang and P-L. Li. Virginia Commonwealth Univ.D518 665.23 Norepinephrine increases the angiotensin IIresponse of interlobar arteries in a hypoxia/reperfusion model.A. Patzak, M. Fähling, M. Sendeski, P.B. Persson and J.Kaufmann. Charité Med. Univ. Berlin.D519 665.24 Sphingosine-1-phosphate evokesvasoconstriction of rat afferent artreioles via activation of S1P1and S1P2 receptors. Z. Guan, M.I. Giddens, A.K. Cook andE.W. Inscho. Med. Col. of Georgia.D520 665.25 Soluble guanylyl cyclase inhibition preventsnebivolol-induced vasodilation in renal afferent arterioles. M-G.Feng and L.G. Navar. Tulane Univ.D521 665.26 Regular oscillations in podocyte calcium in vivo.J. Burford and J. Peti-Peterdi. Univ. of Southern California.D522 665.27 Effects of SGLT-2 blockade on glomerular andtubular function in diabetes. P. Singh, J. Nizar, T. Rieg and S.C.Thomson. UCSD and Scripps Mercy Hosp.D523 665.28 Development and progression ofmicroalbuminuria in spontaneously hypertensive rats. B.H.Inoue, M. Machado, R.O. Crajoinas and A.C. C. Girardi. SãoPaolo Heart Inst.D524 665.29 Salt sensitivity of tubuloglomerular feedback insubtotal nephrectomy. P. Singh, J. Nizar, R. Blantz and S.C.Thomson. UCSD and Scripps Mercy Hosp.D525 665.30 Vasopressin treatment lowers renal outermedullary epoxyeicosatrienoic acid levels in Brattleboro rats.T. Roeschel, T. Kahl, K. Mutig, R. Mrowka, W-H. Schunk,N. Himmerkus, M. Bleich, S. Bachmann and A. Paliege.Charité-Berlin, Friedrich Schiller Univ. Jena, Max DelbrueckCtr. for Molec. Med., Berlin and Christian Albrechts Univ. Kiel,Germany.666. HORMONE, AUTOCOIDPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-3:00 PM<strong>SUNDAY</strong>D526 666.1 Renal functional responses to intrarenalarterial administration of the direct renin inhibitor aliskiren inCyp1a1-Ren2 transgenic rats with ANG II-dependent malignanthypertension. C.G. Howard and K.D. Mitchell. Tulane Univ.D527 666.2 Chronic direct renin inhibition with aliskirenprevents the development of hypertension in Cyp1a1-Ren2transgenic rats with inducible ANG II-dependent hypertension.L. Huang, C.G. Howard and K.D. Mitchell. Tulane Univ.D528 666.3 Chronic renin inhibition normalizes bloodpressure in Cyp1a1-Ren2 transgenic rats with ANG IIdependentmalignant hypertension. G.A. Shamitko, C.G.Howard and K.D. Mitchell. Tulane Univ.D529 666.4 GLP1 receptor activation and DPP-4 inhibitionincrease GFR and induce natriuresis and diuresis in mice. T.Rieg, M. Gerasimova, D.J. Drucker and V. Vallon. UCSD, VASan Diego Healthcare Syst. and Univ. of Toronto.D530 666.5 Klotho regulates ETB receptor expressionvia the PKC/c-Jun pathway. Y. Wang and Z. Sun. Univ. ofOklahoma Hlth. Sci. Ctr.D531 666.6 Glucagon-like peptide-1 induces diuresis andnatriuresis in rats by both renal hemodynamic and tubularmechanisms. B.P. M. Pacheco, R.O. Crajoinas, F.T. Oricchio,L.M. A. Lessa, G. Malnic and A.C. C. Girardi. Univ. of SãoPaulo.204
<strong>SUNDAY</strong>D532 666.7 17β-Estradiol induces Ca 2+ signaling in distalconvoluted tubules and connecting tubules through G-proteincoupled estrogen receptor 1. J. Praetorius, B. Olde, L. M.F.Leeb-Lundberg, R.A. Fenton, H.A. Praetorius and M.V.Hofmeister. Aarhus Univ., Denmark and Lund Univ., Sweden.D533 666.8 Flow-induced NO production is dependent onTRPV4 activation and ATP release in thick ascending limbs.P.D. Cabral and J.L. Garvin. Henry Ford Hosp. and WayneState Univ. Sch. of Med.D534 666.9 Angiotensin II-dependent hypertension bluntsendothelin-1-induced NO production in thick ascending limbs.V.D. Ramseyer and J.L. Garvin. Henry Ford Hlth. Syst. andWayne State Univ.D535 666.<strong>10</strong> Endogenous renal urotensin II and its role insodium and water handling in the young rat. E. Forty and N.Ashton. Univ. of Manchester.D536 666.11 Localization and signaling of FPR2 in thekidney. S. Seidel, A. Paliege, S. Bachmann, R.J. Flower andJ. Peti-Peterdi. Univ. of Southern California, Charité Med. Univ.Berlin and Barts and The London Sch. of Med. and Dent.D537 666.12 Infl uence of hypoxia in catecholaminessynthesis in immortalized human mesangial cell. A.P. Zanini,D.Y. Arita, D.S. Aragão, Z. Palomino Jara, W. Almeida andD.E. Casarini. Fed. Univ. of São Paulo.D538 666.13 Effects of the diabetes in the metabolism of thecatecholamines in rat mesangial cells in culture. R.P. Moreira,T.S. Cunha, F.A. Ronchi, D.Y. Arita, D.S. Aragão, Z. PalominoJara and D.E. Casarini. Fed. Univ. of São Paulo.667. OXIDATIVE STRESSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-3:00 PMD539 667.1 Adaptation to reduction in renal mass inmice: effects of tempol on renal growth, hemodynamics andoxygenation E. Lai, M.L. Onozato, E.H. Rudolph, G. Solis, S.Aslam, Z. Luo, W.J. Welch and C.S. Wilcox. Georgetown Univ.D540 667.2 The Na + /H + exchange inhibitor dimethylamilorideinhibits the activity of NAD(P)H oxidase inmacrophages and renal medullary thick ascending limb: role ofHVCN1. P.M. O’Connor, C. Yang and A.W. Cowley, Jr. Med.Col. of Wisconsin.D541 667.3 Multidrug resistance-related protein 2 defi ciencydoes not enhance acute cyclosporine A nephrotoxicity. O. Grisk,N. Mähler, M. Freyer, R. Kauschke, T. Schlüter, A. Steinbachand R. Rettig. Univ. of Greifswald, Germany.D542 667.4 Regulation of endothelial function byasymmetric dimethylarginine released by vascular smoothmuscle cells during oxidative stress. Z. Luo, W.J. Welch andC.S. Wilcox. Georgetown Univ.D543 667.5 Angiotensin II stimulates superoxide productionby thick ascending limbs by activating NADPH oxidase 4.K.J. Massey, N.J. Hong and J.L. Garvin. Henry Ford Hosp.,Detroit.D544 667.6 Increased Na transport in rat medullary thickascending limb stimulates mitochondrial hydrogen peroxideproduction. Y. Ohsaki, T. Mori, Y. Lu, S. Ito, R.P. Ryan, B.C.Dickinson, C.J. Chang and A.W. Cowley. Med. Col. ofWisconsin, Tohoku Univ. Grad. Sch. of Med., Japan and Univ.of California, Berkeley.D545 667.7 DJ-1 mediates the dopamine D2 receptorregulation of renal ROS production. S. Cuevas Gonzalez,Y. Zhang, Y. Yang, L. Asico, J.E. Jones, P.A. Jose and I.Armando. Children’s Natl. Med. Ctr. and George WashingtonUniv.D546 667.8 Adenosine A1-receptor defi ciency attenuatesAng II and L-NAME-induced hypertension. M. Carlstrom, A.Patzak, X. Gao and E.G. Persson. Uppsala Univ., Swedenand Charité Med. Univ., Berlin.D547 667.9 Uncoupled NOS is a major source of renalsuperoxide in angiotensin II-induced hypertension. M.C.Gongora, W. Chen, L. Li, D. Pollock, J.S. Pollock, H. Cai, K.L.Siu and D.G. Harrison. Emory Univ., Med. Col. of Georgia andUCLA.D548 667.<strong>10</strong> Real-time measurement of free radicals inrenal veins from exposure to extracorporeal shock wavelithotripsy treatment. E.S. Iames, K-A. Perkins, Q. Chen andL.H. Young. Philadelphia Col. of Osteo. Med.D549 667.11 Even delayed targeting of reactive oxygenspecies/oxidative stress protects the renal microcirculationduring sepsis-induced renal injury in mice. Z. Wang, K.A. Seelyand P.R. Mayeux. Univ. of Arkansas for Med. Sci.D550 667.12 Silencing of acid sphingomyelinasegene prevented glomerular oxidative stress and sclerosis inhyperhomocysteinemic mice. M. Xia, K.M. Boini, J.M. Abaisand P-L. Li. Virginia Commonwealth Univ.D551 667.13 Oxidative stress contributes to altered K +channel regulation of afferent arteriolar tone in diabetic ratkidney. C.M. Troncoso Brindeiro, R.W. Fallet and P.K.Carmines. Dartmouth Med. Sch. and Univ. of Nebraska Col. ofMed.668. GRAVITATIONAL AND SPACEPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-3:00 PMPHYSIOLOGYD552 668.1 Effects of microgravity on the creep behaviorof murine intervertebral discs. J.F. Bailey, K.K. Cheng, A.R.Hargens, K. Masuda and J.C. Lotz. UCSF and UCSD.D553 668.2 Effects of G acceleration stress on barorefl exfunction in anesthetized rats. S. Maruyama, T. Kemuriyama,M. Tandai-Hiruma, H. Ohta, A. Tashiro and Y. Nishida. Natl.Defense Med. Col., Japan.D554 668.3 Gravity-independent fl ywheel exercise trainingimproves aerobic capacity and muscle strength in ambulatorysubjects. T. Owerkowicz, J.A. Cotter, P.A. Tesch, V.J. Caiozzoand G.R. Adams. Univ. of California, Irvine and Mid SwedenUniv., Östersund.D555 668.4 The effects of 15d head-down bed rest onvenous compliance of lower limb in women with and withoutexercise countermeasures. M. Yuan, H. Yang, J. Zhang, M.Yuan, J. Wang and L. Wang. China Astronaut Res. and Trng.Ctr., Beijing.D556 668.5 Altered gravity promotes platelet-endothelialcell interactions that precede cardiovascular diseases. D.A.Rubenstein, T. Mujib, J.H. Shaw, P.G. Lloyd and W. Yin.Oklahoma State Univ.D557 668.6 Toe blood pressure and leg muscle oxygenationwith body posture. A. Rosales-Velderrain, M. Cardo, J. Mateus,R. Kumar, T. Schlabs and A.R. Hargens. UCSD and MIT.SUN205
PHYSIOLOGYD558 668.7 Simulated microgravity does not altermyogenesis gene expression in C2C12 cells. K.L. Shimkus,S.B. Zanello, K. Emami and H. Wu. Texas A&M Univ., Univs.Space Res. Assn., Houston, Johnson Space Ctr., NASA andWyle Labs., Houston.D559 668.8 Novel analog for muscle deconditioning. L.Ploutz-Snyder, J. Ryder, R. Buxton, E. Redd, M. Scott-Pandorf, K. Hackney, J. Fiedler, R. Ploutz-Snyder and J.Bloomberg. Univs. Space Res. Assn., Univ. of Houston, WyleIntegrated Sci. and Engin. Gp., Syracuse Univ. and NASA,Houston.D560 668.9 Leucine attenuates muscle loss and facilitatesrecovery following bed rest in middle-aged adults. K.L. English,J.A. Mettler, M.M. Mamerow, M. Sheffield-Moore and D.Paddon-Jones. Univ. of Texas Med. Branch.669. INTERMITTENT HYPOXIA/OXIDATIVE STRESSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-3:00 PMD561 669.1 Acute intermittent hypoxia in rat in vivo elicitslong-term facilitation of recurrent laryngeal nerve activity andmodulates multiple hypoxic chemorefl ex response. T. Xing,T.G. Bautista, A.Y. Fong, M.S. Y. Lung and P.M. Pilowsky.Australian Sch. of Adv. Med., Macquarie Univ.D562 669.2 Technique for in vitro intermittent hypoxiaexposure. J. Polak, K. Studer-Rabeler, M.A. Hussain, N.M.Punjabi and L.A. Shimoda. Johns Hopkins Med. Instns. andCoy Labs., Grass Lake, MI.D563 669.3 Adaptation to intermittent hypoxia preventsrarefaction of the brain vascular net in rats with experimentalAlzheimer’s disease. A.V. Goryacheva, I.V. Barskov, I.V.Viktorov, H.F. Downey and E.B. Manukhina. Inst. of Gen.Pathol. and Pathophysiol. and Sci. Ctr. of Neurol., Moscow andUniv. of North Texas Hlth. Sci. Ctr.D564 669.4 Intermittent hypoxia impairs pancreatic betacellresponse to glucose. N. Wang, J. Jonson, B. Kinsman,N.R. Prabhakar and J. Nanduri. Univ. of Chicago.D565 669.5 Exposure to intermittent hypoxia for 7 daysdoes not alter the intracellular pH response of NTS neuronsto hypercapnic acidosis. Z. Luo and S. Mifflin. Univ. of NorthTexas Hlth. Sci. Ctr.D566 669.6 Exposure to chronic intermittent hypoxia isnot associated with the sympathetic barorefl ex dysfunction. K.Yamamoto, W. Eubank and S. Mifflin. Univ. of North TexasHlth. Sci. Ctr.D567 669.7 Intermittent hypoxia reduces endothelialfunction. B. Williams, J.M. Dorn, A.A. El Solh, R.W. Browneand A.D. Ray. Univ. at Buffalo.D568 669.8 Intermittent hypoxia conditioning attenuatesvascular contractile response to angiotensin-II in spontaneouslyhypertensive rats. D. Jasti, S. Mifflin, E.B. Manukhina andH.F. Downey. Univ. of North Texas Hlth. Sci. Ctr. and Inst. ofGen. Pathol. and Pathophysiol., Moscow.D569 669.9 Angiotensin II evokes sensory long-termfacilitation of the carotid body. Y-J. Peng, G.K. Kumar and N.R.Prabhakar. Univ. of Chicago.D570 669.<strong>10</strong> Intermittent hypoxia attenuates carotid baroreceptoractivity via endothelin-1. Y-J. Peng, J. Nanduri, G.K.Kumar and N.R. Prabhakar. Univ. of Chicago.<strong>SUNDAY</strong>D571 669.11 Role of NFATc3 in vasoconstrictor sensitivity ina mouse model of sleep apnea. J.K. Friedman, C.H. Nitta, K.M.Henderson, S.J. Codianni, N.L. Kanagy and L.V. GonzalezBosc. Univ. of New Mexico Hlth. Sci. Ctr.D572 669.12 Chronic intermittent hypoxia exposure reducesNOS isoforms in internal pudendal artery: linking sleep apneaand erectile dysfunction. K.J. Allahdadi, F.R. Carreno, S.Mifflin and A.M. Schreihofer. Univ. of North Texas Hlth. Sci.Ctr.D573 669.13 Intermittent hypoxia conditioning preventsNO overproduction and accumulation of 3-nitrotyrosine inthe myocardium of rats during ischemia and reperfusion.E.B. Manukhina, A.V. Goryacheva, D.A. Chepurnova, L.M.Belkina, O.L. Terekhina, R.T. Mallet and H.F. Downey. Inst.of Gen. Pathol. and Pathophysiol., Moscow and Univ. of NorthTexas Hlth. Sci. Ctr.D574 669.14 Deltorphin-D decreases H 20 2-inducedmyocardial cell necrosis in rat myoblast cell line. P.R. Oeltgen,P.D. Bishop and S.A. Brown. VA Med. Ctr., Lexington, KY andZymoGenetics Inc., Seattle.D575 669.15 The role of superoxide in muscle vasodilationin chronically hypoxic rats. C.J. Ray and J.M. Marshall. Univ.of Birmingham Sch. of Clin. & Exptl. Med.D576 669.16 Contrasting effects of sustained and intermittenthypoxia on HERG K + channel traffi cking. J. Nanduri, G.Ahmmed, N. Wang and N.R. Prabhakar. Univ. of Chicago.D577 669.17 Intermittent hypoxia enhances neuropeptideY synthesis in adrenal medulla via reactive oxygen speciesdependentalterations in precursor peptide processing. G.Raghuraman, N.R. Prabhakar and G.K. Kumar. Univ. ofChicago.D578 669.18 Mechanisms underlying augmented exocytosiselicited by intermittent hypoxia. D. Souvannakitti, G. Yuan, J.Nanduri, G.K. Kumar and N.R. Prabhakar. Univ. of Chicago.D579 669.19 Neonatal intermittent hypoxia impairs neuronalnicotinic receptor expression and function in adrenal chromaffi ncells. D. Souvannakitti, B. Kuri, G. Yuan, A. Pawar, G.K.Kumar, C. Smith, A.P. Fox and N.R. Prabhakar. Univ. ofChicago and Case Western Reserve Univ.D580 669.20 H2S generated by cystathionine γ-lyasemediates hypoxia-evoked catecholamine secretion fromneonatal adrenal medullary chromaffi n cells. D. Souvannakitti,J. Nanduri, A.P. Fox, M.M. Gadalla, G.K. Kumar, S. Snyderand N.R. Prabhakar. Univ. of Chicago and Johns HopkinsUniv. Sch. of Med.D581 669.21 Hydrogen sulfi de mediates carotid bodyresponse to hypoxia. Y-J. Peng, J. Nanduri, G. Raghuraman,M.M. Gadalla, G.K. Kumar, S. Snyder and N.R. Prabhakar.Univ. of Chicago amd Johns Hopkins Univ.D582 669.22 Hypoxia-inducible factor 1 mediates increasedexpression of NADPH oxidase-2 in response to intermittenthypoxia. G. Yuan, S.A. Khan, W. Luo, G.L. Semenza and N.R.Prabhakar. Univ. of Chicago and Johns Hopkins Univ.D583 669.23 Calcium signaling mediates intermittenthypoxia-induced HIF-2α degradation. J. Nanduri, N. Wangand N.R. Prabhakar. Univ. of Chicago.D584 669.24 Ca 2+ -dependent S-glutathionylation mediatesintermittent hypoxia–induced mitochondrial complex I inhibition.S.A. Khan, G. Yuan, G.K. Kumar and N.R. Prabhakar. Univ. ofChicago.D585 669.25 Cross talk between NADPH oxidase andmitochondrial complex I during intermittent hypoxia. S.A. Khan,J. Nanduri, B. Kinsman, J. Joseph, B. Kalyanaraman andN.R. Prabhakar. Univ. of Chicago and Med. Col. of Wisconsin.206
<strong>SUNDAY</strong>D586 669.26 Dopamine D1 receptor activation mediatesGAD 67 inhibition by intermittent hypoxia. G. Raghuraman,N.R. Prabhakar and G.K. Kumar. Univ. of Chicago.670. HYPOXIA/OXYGEN SENSING, SIGNALTRANSDUCTION, SECOND MESSENGERS, ANDTRANSMITTERSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-3:00 PMD587 670.1 Hypoxia elicits widespread changes in thecellular landscape of protein translocation. L. Zhang, R.M.Henke, R. Ghosh Dastidar, A. Shah, S. Lianoglou, D. Cadinu,J. Hooda and C. Leslie. Univ. of Texas at Dallas and Mem.Sloan-Kettering Cancer Ctr.D588 670.2 Soluble and transmembrane adenylate cyclasesignaling in carotid body type 1 cells using FRET-basedsensors. R. Nunes, V. Sample, E.B. Gauda, Y. Xiang and J.Zhang. Johns Hopkins Med. Instns., Fac. of Med. Sci., Lisbonand Univ. of Illinois at Urbana-Champaign.D589 670.3 Investigating the role of phosphodiesterases 3and 4 in the activation of protein kinase A in superior cervicalganglia using FRET. A.R. Nunes, V. Sample, E. Gauda, Y.Xiang and J. Zhang. Johns Hopkins Med. Instns., Fac. of Med.Sci., Lisbon and Univ. of Illinois at Urbana-Champaign.D590 670.4 Oxygen-glucose deprivation increasesintracellular calcium in NTS neurons. J. Zhang and S. Mifflin.Univ. of North Texas Hlth. Sci. Ctr.PHYSIOLOGYD591 670.5 Hypoxia reduces arylsulfatase B activity inhuman bronchial and colonic epithelial cells and arylsulfataseB expression modifi es HIF-1alpha. J.K. Tobacman and S.Bhattacharyya. Univ. of Illinois at Chicago and Jesse BrownVA Med. Ctr.D592 670.6 Hydrogen sulfi de and oxygen sensing in bovinepulmonary arteries. K.R. Olson and Y. Gao. Indiana Univ. Sch.of Med.-South Bend.D593 670.7 Hypoxic sensitivity in the developing mousecarotid body. E.W. Kostuk, A. Balbir, L. Pichard and M.Shirahata. Johns Hopkins Univ. Bloomberg Sch. of Publ. Hlth.D594 670.8 Oxygen-sensitive properties of serotonergiccells of the skin in developing zebrafi sh. M. Coccimiglio andM. Jonz. Univ. of Ottawa, Canada.D595 670.9 Anti-infl ammatory treatment did not preventthe enhanced rat carotid chemosensory responses to acutehypoxia induced by intermittent hypoxia. R. Iturriaga, E. Moyaand R. Del Rio. Pontifi cal Catholic Univ. of Chile.D596 670.<strong>10</strong> SIRT3 deacetylates FOXO3 to mediatemitochondrial biogenesis during hypoxia. A.H-H. Tseng andD.L. Wang. Inst. of Biomed. Sci., Acad. Sinica, Taipei.D597 670.11 Catalysis of blood sulfi de oxidation bymethemoglobin does not alter the arterial chemorefl ex. P.A.Haouzi and M. Philmon. Penn State Col. of Med.D598 670.12 The effect of hypoxia on ATP release fromhuman umbilical endothelial cells. W.K. L. To, Y. Gu, P. Kumarand J.M. Marshall. Sch. of Clin. and Exptl. Med., Univ. ofBirmingham, U.K.D599 670.13 Measuring the release of ATP from the mousecarotid body. P. Pashai, E.W. Kostuk and M. Shirahata. JohnsHopkins Univ. Bloomberg Sch. of Publ. Hlth.SUNPOSTER PRESENTERS:UPLOAD YOUR POSTERWhere: E-Poster Counter, Hall C LobbyDeadline: Wed., April 13, 3:30 PMUploaded posters will be available online to allregistered attendees following the meeting atwww. experimentalbiology.org207
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