SUNDAY, APRIL 10 Across Societies – Experimental Biology

SUNDAYB341 562.11 Novel role of the transcriptional regulator HIF-1α in the antimicrobial activity of mast cells. M. von Köckritz-Blickwede, K. Branitzki-Heinemann, C. Okumura, H. Naimand V. Nizet. Univ. of Vet. Med. Hannover, Helmholtz Ctr. forInfect. Res., Helmholtz, Germany and UCSD Sch. of Med.B342 562.12 Tetrabromobisphenol A activates mitogenactivatedprotein kinases in human natural killer cells. M.M.Whalen and E.C. Kibakaya. Tennessee State Univ.563. SIGNALING IN DISEASE AND THERAPYPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB343 563.1 Investigation of calcineurin B homolgous protein2 regulation on NHE1: a potential novel therapeutic target totreat non-small cell lung cancer. K. Anderson, A. Slusser, J.Provost and M. Wallert. Minnesota State Univ. Moorhead.B344 563.2 The effect of selective antihypertensive drugson the vascular remodeling-associated hypertension: insightsfrom a profi lin1 transgenic mouse model. M.D. H. Hassona,M.T. Elnakish, Z.A. Abouelnaga, M.A. Alhaj, A.A. Wani andH. Hassanain. Ohio State Univ.B345 563.3 Depolarization-induced slow calcium transientsstimulate neuregulin-1β expression in dystrophic skeletalmuscle cell lines. N. Juretic, G. Jorquera, E. Jaimovich andN. Riveros. Univ. of Chile.B346 563.4 Anti-platelet and anti-thrombotic effects ofselective estrogen receptor modulator tamoxifen. M.K. Nayak,S.K. Singh, A. Roy, V. Prakash, A. Kumar and D. Dash.Banaras Hindu Univ., India.B347 563.5 Molecular and biochemical characterization ofmouse Ellis Van Creveld protein. O.O. Odunuga, A. Monsivais,S.A. Bollinger, K. Choi and E.I. Polvadore. Stephen F. AustinState Univ., TX.B348 563.6 Activated Cdc42 kinase is a cell survival signalin Drosophila melanogaster. J.A. Schoenherr, J.S. Martinez,M.R. Chikka and J.C. Clemens. Purdue Univ.B349 563.7 Glucocorticoids promoteTGF-beta signaling inlung fi broblasts by upregulating ligand and receptor expression,and uncoupling negative-feedback inhibition J.T. Schwartze,N. Kneidinger, W. Seeger and R.E. Morty. Univ. of Giessen,Germany.B350 563.8 C16-ceramide analog combined with Pc4 photodynamic therapy evokes enhanced total ceramideaccumulation, promotion of DEVDase activation in the absenceof apoptosis, and augmented overall cell killing D. Separovic,Z. Saad, E. Edwin, J. Bielawski, J. Pierce, E. Van Buren andA. Bielawska. Wayne State Univ. and Med. Univ. of SouthCarolina.B351 563.9 Phosphorylation of Crk at tyrosine 251 in theRT loop of the SH3C domain downstream of EGFR: novel rolein Abl transactivation. G. Sriram, C. Reichman, K. Machida, B.Mayer, C. Kalodimos and R.B. Birge. UMDNJ, Newark, Univ.of Connecticut Hlth. Ctr. and Rutgers Univ., Piscataway.B352 563.10 The role of marinobufagenin in the causationof a cerebral vascular leak syndrome in a rat model of humanpreeclampsia. M.N. Uddin. Texas A&M Hlth. Sci. Ctr., Temple.B353 563.11 The application of an innate immune agonistin the treatment of ovarian cancer. D.N. Van, C.F. Roberts, S.Lepine and J.K. Bell. Virginia Commonwealth Univ.B354 563.12 Mesenchymal stem cells provide protection ofcardiac ventricular myocytes by paracrine mechanism. R.D.Wardlow II, S. Gaa, D. Riley, W.J. Lederer and T.B. Rogers.Univ. of Maryland Sch. of Med.B355 563.13 Survivin inhibition is critical for Bcl-2 familyinhibitor, ABT-263 to induce apoptosis in liver cancer cells X.Zhao, O. Ogunwobi, D.R. Nelson and C. Liu. Univ. of Florida.564. TRANSCRIPTIONAL REGULATIONPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMBIOCHEMISTRYB356 564.1 Alcohol-mediated decrease in Krüppel-liketranscription factor 4 and its effects on zinc levels in alveolarcells. T.V. Curry-McCoy, D.M. Guidot and P.C. Joshi. EmoryUniv. and VA Med. Ctr., Decatur.B357 564.2 A rapid assay for affi nity and kinetics of DNAproteininteractions. G.P. Donaldson and V.T. Lee. Univ. ofMaryland College Park.B358 564.3 Study of human μ-opioid receptor gene. Y.M.Esteban, L. Rasmussen and J.L. Ko. Seton Hall Univ.B359 564.4 The transcriptional regulation ofN-acetylglutamate synthase and a mutation in the enhancerof the NAGS gene. S.K. Heibel, N. AhMew, I. Nissim, M.Yudkoff, M. Tuchman and L. Caldovic. Children’s Natl. Med.Ctr., Univ. of Maryland College Park and Children’s Hosp. ofPennsylvania.B360 564.5 Expression and purifi cation of an irondependentregulator protein from Thermobifi da fusca. J.J.Hoerr, Z. Lu, J.N. Grow and W.R. P. Novak. Wabash Col.B361 564.6 Functional characterization of a novel BTB/POZ-domain protein ZBTB8A. M-K. Kim, B-N. Jeon and M-W.Hur. Yonsei Univ. Sch. of Med., South Korea.B362 564.7 Mechanism and specifi city of humanmitochondrial transcription factor A binding to the light-strandpromoter. N. Kumar and C.E. Cameron. Penn State.B363 564.8 Analysis of urea cycle gene transcriptionregulation using bioinformatic software and patient sequences.A.L. LaBella, T. Feeney, S.K. Heibel, M. Tuchman and L.Caldovic. Children’s Natl. Med. Ctr., Univ. of Maryland Med.Sch. and Univ. of Maryland College Park.B364 564.9 Differential regulation of human mitochondrialpromoters by transcription factor A. M.F. Lodeiro, T. Shutt,A. Uchida, G. Shadel and C. Cameron. Penn State and YaleUniv. Sch. of Med.B365 564.10 Rac1 attenuates macrophage MMP-9 geneexpression via inhibition of SP-1 at S586. S. Murthy, A.J. Ryanand A.B. Carter. Univ. of Iowa.B366 564.11 Varied mechanisms of estradiol mediatedregulation of dopamine beta-hydroxylase gene transcription. R.Nostramo, L.I. Serova and E.L. Sabban. New York Med. Col.B367 564.12 Evidence for the dynamic association ofproteins with RNA polymerase I. L.I. Rothblum, P. Yvonne andK. Rothblum. Univ. of Oklahoma Col. of Med.B368 564.13 Expression of PP1γ1 and PP1γ2 in testiculargerm cells and Sertoli cells, respectively, is required for normalspermatogenesis N. Sinha, P. Puri and S. Vijayaraghavan.Kent State Univ. and Univ. of Pittsburgh.SUN155