SUNDAY, APRIL 10 Across Societies â Experimental Biology

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PHYSIOLOGYD503 665.8 Dynamical properties of the thick ascendinglimb: a modeling study. A. Nieves-Gonzalez, C. Clausen, H.E.Layton, A.T. Layton and L.C. Moore. Stony Brook Univ. andDuke Univ.D504 665.9 Exogenous L-arginine attenuates thevasoconstrictor response to angiotensin II stimulation inisolated rat aortic rings. S. Das and D.L. Mattson. Med. Col. ofWisconsin.D505 665.10 Adenosine A1-receptors enhance renalafferent arteriole contractile responses to Ang II and L-NAME.X. Gao, A. Patzak, E.G. Persson and M. Carlstrom. UppsalaUniv. and Charité Med. Univ., Berlin.D506 665.11 Renal hemodynamic responses touninephrectomy and ischemia/reperfusion injury: impact ofexercise and rat strain. N. Moningka, M.W. Cunningham, Jr.,M. Sterling and C. Baylis. Univ. of Florida.D507 665.12 Implication of CD38 gene in podocytesepithelial to mesenchymal transition and glomerular sclerosis.K.M. Boini, M. Xia and P-L. Li. Virginia Commonwealth Univ.D508 665.13 Infl uence of high-fructose feeding on functionalα 1-adrenoceptor subtypes in the rat kidney. M.H. Abdulla, E.J.Johns, M.A. Sattar, N.A. Abdullah, M.A. H. Khan and H.A.Rathore. Univ. Sains Malaysia, University Col. Cork, Fac. ofMed., Univ. of Malaya, Malaysia and Med. Col. of Wisconsin.D509 665.14 Inorganic nitrite attenuates Ang II-mediatedcontraction of renal arterioles via xanthine oxidase-dependentgeneration of nitric oxide. M. Carlstrom, X. Gao, A. Patzak, M.Sendeski, J.O. Lundberg and E.G. Persson. Uppsala Univ.,Karolinska Inst. and Charité Med. Univ. Berlin.D510 665.15 An implantable telemetry system for continuouschronic monitoring of kidney oxygenation in freely moving rats.D.M. Russell, E. Garry, R. Evans, G. Eppel, A. Abdelkader,A. Taberner, D. Budgett and S. Malpas. Univ. of Auckland,Blue Box Sensors Ltd., Dublin, Monash Univ., Australia, andTelemetry Res. Ltd., Auckland.D511 665.16 Nitric oxide-dependent modulation of themyogenic response in the renal circulation in eNOS- andnNOS-defi cient mice. M. Dautzenberg, G. Keilhoff and A.Just. Albert Ludwigs Univ. Freiburg and Otto von GuerickeUniv. Magdeburg.D512 665.17 The role of adenosine and ATP intubuloglomerular feedback and RBF autoregulation. M.Dautzenberg and A. Just. Albert Ludwigs Univ. Freiburg.D513 665.18 The SNARE protein VAMP2 but not VAMP3mediates cAMP-stimulated renin release from juxtaglomerularcells. M. Mendez. Henry Ford Hosp., Detroit.D514 665.19 Development of a renal collecting duct homingpeptide using phage display. P. Svenningsen and J. Peti-Peterdi. Univ. of Southern Denmark and Univ. of SouthernCalifornia.D515 665.20 Propagation of vasoconstrictive responses in amathematical model of the rat afferent arteriole. A.T. Layton,I. Sgouralis, H. Layton and L. Moore. Duke Univ. and StonyBrook Univ., SUNY.D516 665.21 Renomedullary blood fl ow and blood volumeare increased during vasopressin escape. F. Palm, P. Liss,A. Fasching, L-O. Magnusson, P. Quick, A. Persson and J.Verbalis. Uppsala Univ. and CMIV, Linköping, Sweden andGeorgetown Univ.D517 665.22 Abrogation by growth hormone of homocysteineinducedepithelial-to-mesenchymal transition through lipid raftredox signaling in podocytes. C-x. Li, M. Xia, W. Han, X-x. Li,C. Zhang and P-L. Li. Virginia Commonwealth Univ.D518 665.23 Norepinephrine increases the angiotensin IIresponse of interlobar arteries in a hypoxia/reperfusion model.A. Patzak, M. Fähling, M. Sendeski, P.B. Persson and J.Kaufmann. Charité Med. Univ. Berlin.D519 665.24 Sphingosine-1-phosphate evokesvasoconstriction of rat afferent artreioles via activation of S1P1and S1P2 receptors. Z. Guan, M.I. Giddens, A.K. Cook andE.W. Inscho. Med. Col. of Georgia.D520 665.25 Soluble guanylyl cyclase inhibition preventsnebivolol-induced vasodilation in renal afferent arterioles. M-G.Feng and L.G. Navar. Tulane Univ.D521 665.26 Regular oscillations in podocyte calcium in vivo.J. Burford and J. Peti-Peterdi. Univ. of Southern California.D522 665.27 Effects of SGLT-2 blockade on glomerular andtubular function in diabetes. P. Singh, J. Nizar, T. Rieg and S.C.Thomson. UCSD and Scripps Mercy Hosp.D523 665.28 Development and progression ofmicroalbuminuria in spontaneously hypertensive rats. B.H.Inoue, M. Machado, R.O. Crajoinas and A.C. C. Girardi. SãoPaolo Heart Inst.D524 665.29 Salt sensitivity of tubuloglomerular feedback insubtotal nephrectomy. P. Singh, J. Nizar, R. Blantz and S.C.Thomson. UCSD and Scripps Mercy Hosp.D525 665.30 Vasopressin treatment lowers renal outermedullary epoxyeicosatrienoic acid levels in Brattleboro rats.T. Roeschel, T. Kahl, K. Mutig, R. Mrowka, W-H. Schunk,N. Himmerkus, M. Bleich, S. Bachmann and A. Paliege.Charité-Berlin, Friedrich Schiller Univ. Jena, Max DelbrueckCtr. for Molec. Med., Berlin and Christian Albrechts Univ. Kiel,Germany.666. HORMONE, AUTOCOIDPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-3:00 PMSUNDAYD526 666.1 Renal functional responses to intrarenalarterial administration of the direct renin inhibitor aliskiren inCyp1a1-Ren2 transgenic rats with ANG II-dependent malignanthypertension. C.G. Howard and K.D. Mitchell. Tulane Univ.D527 666.2 Chronic direct renin inhibition with aliskirenprevents the development of hypertension in Cyp1a1-Ren2transgenic rats with inducible ANG II-dependent hypertension.L. Huang, C.G. Howard and K.D. Mitchell. Tulane Univ.D528 666.3 Chronic renin inhibition normalizes bloodpressure in Cyp1a1-Ren2 transgenic rats with ANG IIdependentmalignant hypertension. G.A. Shamitko, C.G.Howard and K.D. Mitchell. Tulane Univ.D529 666.4 GLP1 receptor activation and DPP-4 inhibitionincrease GFR and induce natriuresis and diuresis in mice. T.Rieg, M. Gerasimova, D.J. Drucker and V. Vallon. UCSD, VASan Diego Healthcare Syst. and Univ. of Toronto.D530 666.5 Klotho regulates ETB receptor expressionvia the PKC/c-Jun pathway. Y. Wang and Z. Sun. Univ. ofOklahoma Hlth. Sci. Ctr.D531 666.6 Glucagon-like peptide-1 induces diuresis andnatriuresis in rats by both renal hemodynamic and tubularmechanisms. B.P. M. Pacheco, R.O. Crajoinas, F.T. Oricchio,L.M. A. Lessa, G. Malnic and A.C. C. Girardi. Univ. of SãoPaulo.204
SUNDAYD532 666.7 17β-Estradiol induces Ca 2+ signaling in distalconvoluted tubules and connecting tubules through G-proteincoupled estrogen receptor 1. J. Praetorius, B. Olde, L. M.F.Leeb-Lundberg, R.A. Fenton, H.A. Praetorius and M.V.Hofmeister. Aarhus Univ., Denmark and Lund Univ., Sweden.D533 666.8 Flow-induced NO production is dependent onTRPV4 activation and ATP release in thick ascending limbs.P.D. Cabral and J.L. Garvin. Henry Ford Hosp. and WayneState Univ. Sch. of Med.D534 666.9 Angiotensin II-dependent hypertension bluntsendothelin-1-induced NO production in thick ascending limbs.V.D. Ramseyer and J.L. Garvin. Henry Ford Hlth. Syst. andWayne State Univ.D535 666.10 Endogenous renal urotensin II and its role insodium and water handling in the young rat. E. Forty and N.Ashton. Univ. of Manchester.D536 666.11 Localization and signaling of FPR2 in thekidney. S. Seidel, A. Paliege, S. Bachmann, R.J. Flower andJ. Peti-Peterdi. Univ. of Southern California, Charité Med. Univ.Berlin and Barts and The London Sch. of Med. and Dent.D537 666.12 Infl uence of hypoxia in catecholaminessynthesis in immortalized human mesangial cell. A.P. Zanini,D.Y. Arita, D.S. Aragão, Z. Palomino Jara, W. Almeida andD.E. Casarini. Fed. Univ. of São Paulo.D538 666.13 Effects of the diabetes in the metabolism of thecatecholamines in rat mesangial cells in culture. R.P. Moreira,T.S. Cunha, F.A. Ronchi, D.Y. Arita, D.S. Aragão, Z. PalominoJara and D.E. Casarini. Fed. Univ. of São Paulo.667. OXIDATIVE STRESSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-3:00 PMD539 667.1 Adaptation to reduction in renal mass inmice: effects of tempol on renal growth, hemodynamics andoxygenation E. Lai, M.L. Onozato, E.H. Rudolph, G. Solis, S.Aslam, Z. Luo, W.J. Welch and C.S. Wilcox. Georgetown Univ.D540 667.2 The Na + /H + exchange inhibitor dimethylamilorideinhibits the activity of NAD(P)H oxidase inmacrophages and renal medullary thick ascending limb: role ofHVCN1. P.M. O’Connor, C. Yang and A.W. Cowley, Jr. Med.Col. of Wisconsin.D541 667.3 Multidrug resistance-related protein 2 defi ciencydoes not enhance acute cyclosporine A nephrotoxicity. O. Grisk,N. Mähler, M. Freyer, R. Kauschke, T. Schlüter, A. Steinbachand R. Rettig. Univ. of Greifswald, Germany.D542 667.4 Regulation of endothelial function byasymmetric dimethylarginine released by vascular smoothmuscle cells during oxidative stress. Z. Luo, W.J. Welch andC.S. Wilcox. Georgetown Univ.D543 667.5 Angiotensin II stimulates superoxide productionby thick ascending limbs by activating NADPH oxidase 4.K.J. Massey, N.J. Hong and J.L. Garvin. Henry Ford Hosp.,Detroit.D544 667.6 Increased Na transport in rat medullary thickascending limb stimulates mitochondrial hydrogen peroxideproduction. Y. Ohsaki, T. Mori, Y. Lu, S. Ito, R.P. Ryan, B.C.Dickinson, C.J. Chang and A.W. Cowley. Med. Col. ofWisconsin, Tohoku Univ. Grad. Sch. of Med., Japan and Univ.of California, Berkeley.D545 667.7 DJ-1 mediates the dopamine D2 receptorregulation of renal ROS production. S. Cuevas Gonzalez,Y. Zhang, Y. Yang, L. Asico, J.E. Jones, P.A. Jose and I.Armando. Children’s Natl. Med. Ctr. and George WashingtonUniv.D546 667.8 Adenosine A1-receptor defi ciency attenuatesAng II and L-NAME-induced hypertension. M. Carlstrom, A.Patzak, X. Gao and E.G. Persson. Uppsala Univ., Swedenand Charité Med. Univ., Berlin.D547 667.9 Uncoupled NOS is a major source of renalsuperoxide in angiotensin II-induced hypertension. M.C.Gongora, W. Chen, L. Li, D. Pollock, J.S. Pollock, H. Cai, K.L.Siu and D.G. Harrison. Emory Univ., Med. Col. of Georgia andUCLA.D548 667.10 Real-time measurement of free radicals inrenal veins from exposure to extracorporeal shock wavelithotripsy treatment. E.S. Iames, K-A. Perkins, Q. Chen andL.H. Young. Philadelphia Col. of Osteo. Med.D549 667.11 Even delayed targeting of reactive oxygenspecies/oxidative stress protects the renal microcirculationduring sepsis-induced renal injury in mice. Z. Wang, K.A. Seelyand P.R. Mayeux. Univ. of Arkansas for Med. Sci.D550 667.12 Silencing of acid sphingomyelinasegene prevented glomerular oxidative stress and sclerosis inhyperhomocysteinemic mice. M. Xia, K.M. Boini, J.M. Abaisand P-L. Li. Virginia Commonwealth Univ.D551 667.13 Oxidative stress contributes to altered K +channel regulation of afferent arteriolar tone in diabetic ratkidney. C.M. Troncoso Brindeiro, R.W. Fallet and P.K.Carmines. Dartmouth Med. Sch. and Univ. of Nebraska Col. ofMed.668. GRAVITATIONAL AND SPACEPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:45 PM-3:00 PMPHYSIOLOGYD552 668.1 Effects of microgravity on the creep behaviorof murine intervertebral discs. J.F. Bailey, K.K. Cheng, A.R.Hargens, K. Masuda and J.C. Lotz. UCSF and UCSD.D553 668.2 Effects of G acceleration stress on barorefl exfunction in anesthetized rats. S. Maruyama, T. Kemuriyama,M. Tandai-Hiruma, H. Ohta, A. Tashiro and Y. Nishida. Natl.Defense Med. Col., Japan.D554 668.3 Gravity-independent fl ywheel exercise trainingimproves aerobic capacity and muscle strength in ambulatorysubjects. T. Owerkowicz, J.A. Cotter, P.A. Tesch, V.J. Caiozzoand G.R. Adams. Univ. of California, Irvine and Mid SwedenUniv., Östersund.D555 668.4 The effects of 15d head-down bed rest onvenous compliance of lower limb in women with and withoutexercise countermeasures. M. Yuan, H. Yang, J. Zhang, M.Yuan, J. Wang and L. Wang. China Astronaut Res. and Trng.Ctr., Beijing.D556 668.5 Altered gravity promotes platelet-endothelialcell interactions that precede cardiovascular diseases. D.A.Rubenstein, T. Mujib, J.H. Shaw, P.G. Lloyd and W. Yin.Oklahoma State Univ.D557 668.6 Toe blood pressure and leg muscle oxygenationwith body posture. A. Rosales-Velderrain, M. Cardo, J. Mateus,R. Kumar, T. Schlabs and A.R. Hargens. UCSD and MIT.SUN205
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SUNDAY, APRIL 10 Across Societies â Experimental Biology

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SUNDAY, APRIL 10 Across Societies â Experimental Biology