SUNDAY, APRIL 10 Across Societies – Experimental Biology

SUNDAYC289 627.4 Regulation of DOR and DOR-KOR heteromersignaling in peripheral sensory neurons. B.A. McGuire, T.A.Sanchez, Y.M. Silva, M.P. Rowan, W.P. Clarke and K.A. Berg.Univ. of Texas Hlth. Sci. Ctr. at San Antonio.628. GPCR — DESENSITIZATION/TRAFFICKINGPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:30 PM-2:45 PMC290 628.1 Cell type-dependent internalization of the ADPactivatedP2Y1 receptor. A-D. Qi, D.M. Glast, T.K. Harden andR.A. Nicholas. Univ. of North Carolina at Chapel Hill.C291 628.2 Peptide inhibitors of GRK phosphorylation ofrhodopsin. F. Baameur, R.A. Hammitt, R.B. Clark and J.S.McMurray. Univ. of Texas Hlth. Sci. Ctr. at Houston and MDAnderson Cancer Ctr.C292 628.3 Retromer terminates the generation ofcAMP by internalized G protein-coupled PTH receptors. T.N.Feinstein and J-P. Vilardaga. Univ. of Pittsburgh Sch. of Med.and Massachusetts Gen. Hosp. and Harvard Med. Sch.C293 628.4 Novel insights into the role of arrestin-2 inendosomal sorting of CXCR4. R. Malik and A. Marchese.Loyola Univ. Chicago, Maywood.C294 628.5 Phosphorylated serine and threonine residuesof PAR2 C-terminus direct β-arrestin 1/2 recruitment andbinding. K. Pal and K. DeFea. Univ. of California, Riverside.C295 628.6 SAP97 controls β1-adrenergic receptortraffi cking in a PDZ-dependent manner. M.M. Nooh and S.W.Bahouth. Univ. of Tennessee Hlth. Sci. Ctr., Memphis and Fac.of Pharm., Cairo Univ.C296 628.7 Rab8 interacts with distinct motifs in α2B- andβ2-adrenergic receptors and differentially modulates theirtransport. C. Dong, L. Yang, X. Zhang, H. Gu, H. Xia, M.L. Lam,W.C. Claycomb and G. Wu. LSU Hlth. Sci. Ctr., New Orleans.C297 628.8 The human prostacyclin receptorcontains a novel Rab11 binding domain that is regulated bypalmitoylation. E.C. Turner, E.P. Mulvaney, H.M. Reid and B.T.Kinsella. University Col. Dublin Sch. of Biomolec. & Biomed.Sci.C298 628.9 N-linked glycosylation of protease-activatedreceptor-1 regulates receptor activation and internalization.A.G. Soto and J. Trejo. UCSD.C299 628.10 Palmitoylation of protease-activated receptor-1:regulation of receptor ubiquitination and intracellular traffi cking.I. Canto and J. Trejo. UCSD Sch. of Med.C300 628.11 Modulation of α- 2Cadrenergic receptorintracellular traffi cking by arginine-based motifs. C. Filipeanu.LSU Hlth. Sci. Ctr., New Orleans.C301 628.12 Comparison of the effects of proteasomalinhibitors and lysosomal inhibitors on the carbachol-induceddownregulation of M 1-M 4receptors. A. Thangaraju and G.W.Sawyer. Oklahoma State Univ. Ctr. for Hlth. Sci.C302 628.13 Ipsen 5i is a novel melanocortin-4 receptorpharmacological chaperone. Y-X. Tao. Auburn Univ.629. GPCR — ACTIVATION MECHANISMSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:30 PM-2:45 PMC303 629.1 Agonist dependent tolerance property ofD3 dopamine receptor: a role for second extracellular loopresidues. E.V. Kuzhikandathil, S. Gil-Mast and S. Kortagere.UMDNJ-New Jersey Med. Sch. and Drexel Univ. Col. of Med.C304 629.2 Analysis of dopamine D2 receptor mutantsdefi cient in arrestin binding using bioluminescence resonanceenergy transfer. C.C. Clayton and K.A. Neve. Oregon Hlth. &Sci. Univ. and Portland VA Med. Ctr.C305 629.3 Adhesion via the N-terminus shapes themasking and traffi c of the neuropeptide Y Y2 receptor. S.L.Parker and M.S. Parker. Univ. of Tennessee Hlth. Sci. Ctr. andUniv. of Memphis.C306 629.4 Regulation and signaling of the orphan GPCRbrain angiogenesis inhibitor-1. J.R. Stephenson, K.J. Paavolaand R.A. Hall. Emory Univ.C307 629.5 The GPR56 N-terminus controls receptorsignaling activity. K.J. Paavola, J.R. Stephenson and R.A.Hall. Emory Univ.C308 629.6 Comparison of the activation kinetics of the M3-ACh-receptor and a constitutive active mutant receptor in livingcells. C. Hoffmann, S. Nuber, U. Zabel, N. Ziegler, P. Hein, M.Lohse and M. Buenemann. Univ. of Wuerzburg, Germany.C309 629.7 Agonist-dependent oxidation of the β2adrenergic receptor: selective cysteine sulfenic acid formationas detected by a modifi ed biotin-switch assay. R.N. Burns andN.H. Moniri. Col. of Pharm. and Hlth. Sci., Mercer Univ.630. ENDOTHELIAL CELLS — OXIDATIVE STRESSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:30 PM-2:45 PMPHARMACOLOGYC310 630.1 The protective effects of Angelica sinesisextracts against tert-butyl hydroperoxide induced oxidativestress and apoptosi in rat vascular endothelial cells. Y-C. Yeh,J-C. Lo, L-C. Wang and H-C. Ou. Grad. Inst. of Nat. HealingSci., Chiayi Cty., Ctr. of Cardiovasc., Taichung and Grad. Inst.of Rehabil. Sci., Taichung, Taiwan.C311 630.2 Lysosomal fusion mediated super oxideproduction in hyperglycaemia-induced endothelial dysfunction.J-X. Bao, H. Chang, Y-G. Bai, J-W. Yu, Z-B. Yu and J. Ma.Fourth Military Med. Univ., People’s Republic of China.C312 630.3 Ergothioneine shows protective effect onendothelial cells in oxidative stress. A.S. M. Sit, E.Y. W. Ho,R.W. S. Li, R.Y. K. Man, Y.W. Kwan, P.M. Vanhoutte and G.P.H. Leung. Univ. of Hong Kong and Chinese Univ. of HongKong.C313 630.4 Inhibition of oxidative radical productionprevents diabetes-induced vascular dysfunction throughdecreased arginase activation. L. Yao, S. Chandra, H.A.Toque, Z. Xu, R.B. Caldwell and R.W. Caldwell. Med. Col. ofGeorgia.SUN183