SUNDAY, APRIL 10 Across Societies – Experimental Biology

SUNDAY569. CHEMICAL PROBES AND THEIR USE INIDENTIFYING NEW THERAPEUTIC TARGETSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB393 569.1 Development of bifunctional small moleculesas chemical tools and potential therapeutics for Alzheimer’sdisease. J-S. Choi and M.H. Lim. Univ. of Michigan.B394 569.2 Sterol-hydrazone derivatives as inhibitorsof the fungal Δ24-sterol methyl transferase. G. San-Blas, G.Visbal, J. Murgich and G. Niño-Vega. IVIC, Caracas.B395 569.3 Mechanistic studies of the antiproliferative andimmunosuppressive natural product triptolide. D.V. Titov, B.Gilman, Q-L. He, S. Bhat, W-K. Low, M. Smeaton, A. Demain,P. Miller, J. Kugel, J. Goodrich and J.O. Liu. Johns HopkinsUniv. Sch. of Med., Univ. of Colorado at Boulder, Johns HopkinsUniv. Bloomberg Sch. of Publ. Hlth. and Drew Univ., NJ.570. HIGH-CONTENT APPROACHESPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB396 570.1 Engineered heart tissues in high-throughputtoxic compound screening. V. Rufanova, W. Baehr, M. Gerger,A. Badic and T. Wakatsuki. InvivoSci. LLC, Wauwatosa, WIand Med. Col. of Wisconsin.571. NEW SPECTROSCOPIC TECHNIQUES FORCHEMICAL BIOLOGISTSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB397 571.1 Pathways to natural organochlorine formationin decaying plant material: a novel assay. L. Herren and A.Leri. Marymount Manhattan Col.572. PROTEIN-SMALL MOLECULE INTERACTIONSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB398 572.1 Structure activity relationships of para- andmeta-hydroxyl derivatives of the Jak2 inhibitor G6: signifi canceof the para-hydroxyl conformation. R. Baskin, A. Majumder,C. Fuhrman, M. Gali, K.S. Bisht and P.P. Sayeski. Univ. ofFlorida and Univ. of South Florida.B399 572.2 Molecular dynamics study of furanose bindingprotein. B. Dow and J. Rhoad. Missouri Western State Univ.B400 572.3 Aminoglycoside phosphotransferasescatalyze the formation of an inhibitor of the DWI/SNF familyof DNA-dependent ATPases. P. Dutta, S.S. Komath and R.Muthuswami. Sch. of Life Sci., Jawaharlal Nehru Univ., India.B401 572.4 Identifi cation of residues involved in ligandbinding specifi city in the dihydrofolate reductase family. S.M.Hall, N. Goodey, K. Herbert and H. Obeidallah. MontclairState Univ., NJ.B402 572.5 Structural insights for aminoglycoside-inducednephrotoxicity: molecular modeling studies of the calreticulingentamicincomplex. G. Hariprasad, U. Das, M. Kumar, P.Kaur, T.P. Singh and A. Srinivasan. All India Inst. of Med. Sci.,New Delhi.B403 572.6 Carnosine promotes GAPDH dimer formation:proposed role in preventing neurodegeneration. J.Y. Kim andN.W. Seidler. Kansas City Univ. of Med. and Biosci.B404 572.7 A mutant of platelet-activating factoracetylhydrolase hydrolyzes the nerve agent soman. S. Kirby,J. Norris, D.M. Cerasoli and B. Bahnson. U.S. Army Med.Res. Inst. of Chem. Def., Aberdeen Proving Ground, MD andUniv. of Delaware.B405 572.8 Structure-based insight into the mechanism oftype I dehydroquinate dehydratases. S.H. Light, G. Minasov,M-E. Duban, L. Shuvalova, M. Caffrey, A. Lavie and W.F.Anderson. Northwestern Univ., Chicago and Univ. of Illinois atChicago.B406 572.9 NMR studies reveal unexpected binding sitefor APE1 redox inhibitor. B. Manvilla, O. Wauchope, K. Seley-Radtke and A.C. Drohat. Univ. of Maryland Baltimore andUniv. of Maryland Baltimore County.B407 572.10 Construction and validation of a random 21-mer phage-peptide library. Y. Yamamoto, S. Shah, E. Yoderand A.G. Rao. Iowa State Univ. and Maple Valley Anthon OtoH.S., Mapleton, IA.B408 572.11 Selection and characterization of peptidesbinding with high affi nity to metal ions using a 21-mer randomphage-displayed peptide library. Y. Yamamoto and A.G. Rao.Iowa State Univ.573. SMALL MOLECULE TOOLS FOR BIOLOGYPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMBIOCHEMISTRYB409 573.1 Effects of polynitrogen compounds on theactivity of recombinant human hypoxia inducible factor -1αprolylhydroxylase 3 in Escherichia coli. Z. Geng, J. Cao, X. Ma, C. Liand Z. Wang. Sch. of Chem. and Chem. Engin., Nanjing Univ.,People’s Republic of China.B410 573.2 Exploring the effi cacy of small moleculeinhibitors of AKAP-PKA interactions. M.C. Moutty, K. Zühlke,J. Milic, V. Tabor, A. Goncalves, C. Noack, F. Christian, S.Grossmann, J.P. von Kries, W. Rosenthal and E. Klussmann.Leibniz Inst. for Molec. Pharmacol., Max-Delbrück-Ctr. forMolec. Med. and Charité Univ. Med. Berlin.SUN157