SUNDAY, APRIL 10 Across Societies – Experimental Biology

SUNDAYC247 621.4 A synthetic polyphenol compound, 3-geranyl-2,4,6-trihydroxy-acetophenone, induces apoptosis andchemosensitization of adriamycin-resistant MCF-7 breastcancer cells Y-R. Kang, M-Y. Cho, S-Y. Park, Y.R. Lee, K.W.Kang, J-A. Kim and S.S. Han. Sch. of Pharm., Sch. of ChemEngin. and Technol. and Sch. of Textiles, Yeungnam Univ. andChosun Univ. Col. of Pharm., South Korea.C248 621.5 The effect of Momordica charantiaextract oncolorectal cancer precancerous lesions (aberrant crypt foci).T.S. Wynter, P. Singh, N. Williams and W. Mclaughlin. Univ.of West Indies, Jamaica.C249 621.6 The inhibitory effect of 5-hydroxyhexamethoxyflavone on human colon cancer cells. P. Qiu,H. Guan, J. Zheng, S. Guo, M. Song and H. Xiao. Univ. ofMassachusetts Amherst and Ocean Univ. of China.C250 621.7 Aciculatin, a C-glycosidic fl avonoid, inducesp53-dependent cell cycle arrest and apoptosis in HCT116colorectal cancer cells C-y. Lai, S-L. Pan, C-C. Chen and C-M.Teng. Col. of Med.. Natl. Taiwan Univ. and Hungkuang Univ.,Taiwan.C251 621.8 Anticancer activity of trilinolein from Panaxnotoginseng in human nonsmall cell lung cancer cells A549.P-Y. Chou. Natl. Chung Hsing Univ., Taiwan.622. CHEMOTHERAPY — NUCLEIC ACID-BASEDAPPROACHES TO THERAPYPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:30 PM-2:45 PMC252 622.1 Identifi cation of novel chemosensitivity nodesfor vinblastine using siRNA synthetic lethal screens. C.A.Kitchens, P.R. McDonald, T.Y. Shun, I.F. Pollack and J.S.Lazo. Univ. of Pittsburgh.C253 622.2 The effi ciency of Nek2 siRNA for livermetastasis of pancreatic cancer. T. Kokuryo, Y. Yokoyama, T.Seki, A. Nakagawa and M. Nagino. Nagoya Univ. Grad. Sch.of Med.C254 622.3 microRNA signaling in stem-like ABCG2 +retinoblastoma cells. Y. Pan, G.M. Seigel, Z. Hu and A. Yu.SUNY at Buffalo, Amherst.C255 622.4 Aptamer-mediated complement system killingof MCF-7 and MEAR cancer cells. J.R. Stecker, J.G. Brunoand J.R. Koke. Texas State Univ., San Marcos and OTCBiotechnol. LLC, San Antonio.C256 622.5 Internalization of the DNA TLS-11a aptamer inMEAR liver hepatoma cells. J.R. Stecker, J.G. Bruno and J.R.Koke. Texas State Univ., San Marcos and OTC Biotech. LLC,San Antonio.623. DRUG DISCOVERY, DEVELOPMENT ANDREGULATORY AFFAIRSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:30 PM-2:45 PMPHARMACOLOGYC257 623.1 Marine pharmacology and the 2011pharmaceuticals pipeline. A.M. Mayer and K.B. Glaser.Midwestern Univ., IL and Abbott Labs.C258 623.2 Current drug scheduling reviews reported bythe DEA. M.D. Walker, C. Prioleau, S. Ghozland, T. Boos, S.Tella and C. Sannerud. Drug Enforcement Admin., Arlington,VA.C259 623.3 Preparation of a dual claudin binder using afragment of Clostridium perfringens enterotoxin. A. Takahashi,Y. Saito, K. Matsuhisa, Y. Kakamu, M. Kodaka, A. Watari, M.Kondoh and K. Yagi. Grad. Sch. of Pharmaceut. Sci., OsakaUniv.C260 623.4 A substrate-based approach to convertserpinB1 into a specifi c inhibitor of proteinase 3, the Wegenergranulomatosis autoantigen B. Korkmaz, G. Jégot, C.Derache, E. Remold-O’Donnell, C. Kellenberger and F.Gauthier. INSERM, Tours and CNRS Orléans and Marseille.C261 623.5 Pharmacological assessment of a hialuronanjelly to wound healing. biochemical evaluation of dermalreconstitution. L. Oruña and G.M. Coto. State Quality Cntrl.Drug Ctr. and Placental Histotherapy Ctr., Havanna.C262 623.6 Bioassay-guided evaluation of wound healingeffect of atranorin in rodents. R.S. Barreto, B. E.S. Araújo, J.S.Siqueira, J.M. DeSantana, A. Araújo, A.S. Barreto, M.R. V.Santos, R. L.C. Albuquerque, Jr. and L.J. Quintans, Jr. Fed.Univ. of Sergipe and Tiradentes Univ., Brazil.C263 623.7 Comparisons of intranasal delivery offl uorescent probe Cy5.5 and i.v. injection of Cy5.5. H. Chen,C. Sheng, N. Liu, B. Wang, J. Peng, W. Xia and W. Ying.Shanghai Jiao Tong Univ., People’s Republic of China.C264 623.8 Progress toward developing an intranasal genetherapy approach for CNS disorders. B. Harmon, M. Cooper,M. Migliore, R. Loring and B. Waszczak. Northeastern Univ.,Copernicus Therapeut. Inc., Cleveland and Massachusetts Col.of Pharm. and Hlth. Sci.C265 623.9 Generation and in vitro characterization oftherapeutic anti-methamphetamine antibody-nanoparticleconjugates. N.G. Nanaware, G.A. Gonzalez III and E.C.Peterson. Univ. of Arkansas for Med. Sci.C266 623.10 High throughput identifi cation of mitochondrialtoxicophores. R.E. Trager, L. Wills, C. Lindsey, G. Beeson,C. Beeson, R. Schnellmann and Y. Peterson. Med. Univ. ofSouth Carolina and Ralph H. Johnson VA Med. Ctr.C267 623.11 Developing novel fatty acid amide hydrolaseinhibitors for the treatment of pain. J. Faloon, C. Ezzili, D.Giuvelis, J.J. Lowery, N. McGlinchey, D. Boger and E.J.Bilsky. Univ. of New England and The Scripps Res. Inst.C268 623.12 The fl uid from the immature fl ower bud ofSpathodea campanulata reduces intraocular pressure in dogs.C.L. S. Golding, M.E. West, M-L.G. McKoy and E.A. Thomas.Univ. of West Indies, Jamaica.SUN181