SUNDAY, APRIL 10 Across Societies – Experimental Biology

SUNDAYBIOCHEMISTRYBiochemistry and Molecular Biology498. ABERRANT DNA REPAIR, GENOMICINSTABILITY AND CANCERPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB1 498.1 Transcriptional response to loss of RNase H2activity in Saccharomyces cerevisiae. M.E. Arana, R.T. Kerns,P.R. Bushel and T.A. Kunkel. NIEHS, NIH, Research TrianglePark.B2 498.2 Inhibition of DNA helicase activity determinedby SPR. W.M. David, S.M. Kerwin and M.J. Decker. TexasState Univ., San Marcos and Univ. of Texas at Austin.B3 498.3 Polymorphic variants of human DNAglycosylase NEIL2 and lung cancer susceptibility. S. Dey, A.K.Maiti, M.L. Hegde, P.M. Hegde, B. Shen, I. Boldogh, J. Xie, V.Cardenas and T.K. Hazra. Univ. of Texas Med. Branch, City ofHope and Indiana Univ.-Purdue Univ. Indianapolis.B4 498.4 Mitotic analysis as a measure of genomicinstability during the propagation of human pluripotentstem cells. V. Fields, M.J. Riggs and R.R. Rao. VirginiaCommonwealth Univ.B5 498.5 A novel role of RGS6 in oncogenic Ras-inducedcellular transformation. J. Huang, J. Yang, J. Hagen, D. Quelleand R. Fisher. Univ. of Iowa.B6 498.6 Regulation and function of the TAZ transcriptionco-activator. Q. Lei. Sch. of Med., Fudan Univ., People’sRepublic of China.B7 498.7 The role of recombination genes duringtelomere maintenance in telomerase-defi cient tumors andprimary cells. T.A. Morrish, V. Behera, M.A. Strong and C.W.Greider. Johns Hopkins Univ.B8 498.8 Syzgium guineensis extracts display cellspecifi c anticancer properties. A. Nkembo, N.S. Lamango,H. Gokham, L. Ayuk-Takem, R. Duverna, R. Marijani and B.Abonyo. Florida A&M Univ.B9 498.9 Studies on the utilization of a thioaptamer forthe rescue of p53 and its mutants. L.P. Rangel, A. P.D. AnoBom and J.L. Silva. Fed. Univ. of Rio de Janeiro and OswaldoCruz Fndn., Rio de Janeiro.B10 498.10 Homologous recombination independent rolefor BRCA2 in blocking stalled replication fork degradation byMRE11. K. Schlacher, N. Christ and M. Jasin. Mem. Sloan-Kettering Cancer Ctr. and UCLA.B11 498.11 RNA polymerase II CTD-associated DNA repairand recombination. T. Winsor, C. Bennett and A. Greenleaf.Duke Univ.499. DNA DAMAGE SIGNALINGPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB12 499.1 In vitro studies of MutSalpha protein inmismatch excision repair and DNA damage signaling. H. Gengand P. Hsieh. NIDDK, NIH.B13 499.2 Loss of p300 induces a rapid aging phenotypeand blunts ATM-initiated DNA damage response. S. Jain, C.Rodrigues, J. Wei and N.H. Bishopric. Univ. of Miami.500. DNA REPAIR MECHANISMSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB14 500.1 Identifi cation of Escherichia coli processingactivities for covalent topoisomerase-DNA complexes. S. Aedoand Y-C. Tse-Dinh. New York Med. Col.B15 500.2 Dissecting cellular inter-strand crosslink repairpathways through the recruitment kinetics of Fanconi anemiaproteins to localized ICLs. M.A. Bellani, P. Muniandy, M.Paramasivam, A. Smogorzewska, W. Wang, J. de Winterand M.M. Seidman. NIA, NIH, Baltimore, Dana Farber Inst.,Rockefeller Univ. and Free Univ. Med. Ctr., Amsterdam.B16 500.3 Conformational explorations into DNApolymerase X from African swine fever virus in the presenceof oxoG lesions. J. Bogdanovic, Z. Barbati, T. Schlick, K.Arora and B.A. S. Benitez. Marymount Manhattan Col., Univ.of Copenhagen, NYU and Univ. of Michigan.B17 500.4 Developing reporter systems to monitor thestructural dynamics of MutS, a DNA mismatch repair protein C.Doucette, M. Hingorani and F.N. Biro. Wesleyan Univ.B18 500.5 NEIL1’s common interaction peptide acts asdominant negative inhibitor of NEIL1-initiated base excisionrepair of oxidized bases: potential for adjuvant cancer therapy.M.L. Hegde, P.M. Hegde, T.K. Hazra, I. Boldogh and S. Mitra.Univ. of Texas Med. Branch.B19 500.6 Deciphering the origin of multiple substratespecifi city of the repair enzyme, AlkB N. Jayanth, N. Ogiralaand M. Puranik. Natl. Ctr. for Biol. Sci., Bangalore.B20 500.7 A structural hinge in the eukaryotic DNA repairglycosylase, MutY homologue, mediates catalytic activity andinteractions with the Rad9-Rad1-Hus1 checkpoint complex P.J.Luncsford, D-Y. Chang, G. Shi, J. Bernstein, A. Madabushi,D.N. Patterson, A-L. Lu and E.A. Toth. Univ. of Maryland Sch.of Med.B21 500.8 Crystal structure of human thymine DNAglycosylase bound to a DNA substrate analog reveals themolecular basis of specifi city and catalysis. A. Maiti, E.Pozharski and A.C. Drohat. Univ. of Maryland Sch. of Med.and Sch. of Pharm.B22 500.9 APE1/Ref-1: a multi-functional protein thatprotects neurons against amyloid beta toxicity. A.K. Mantha,J.R. Perez-Polo and S. Mitra. Univ. of Texas Med. Branch.B23 500.10 Molecular clues to alkylating agent-induced celldeath and drug resistance. M. Fried, G-M. Li and F. Odago.Univ. of Kentucky.B24 500.11 E. coli UmuD conformational dynamics inresponse to DNA damage. J. Ollivierre, Q. Huang, D. Budiland P.J. Beuning. Northeastern Univ.B25 500.12 A novel role for the VapB-2 antitoxin ofnontypeable Haemophilus infl uenzae in genomic stabilityfollowing oxidative stress. D. Ren, S.D. Cline, C. Bell III andD.A. Daines. Mercer Univ. Sch. of Med.SUN139