SUNDAY, APRIL 10 Across Societies – Experimental Biology

SUNDAYC139 614.20 Role of Th17 T-lymphocytes in advanced aidspatients with marked CD4 + T cell depletion. W.L. Singleterry,R.E. Lewis, S. Bigler and J.M. Cruse. Univ. of MississippiMed. Ctr.C140 614.21 Reversible myocardial dysfunction in HIV-Tattransgenic mouse. F. Chen, J.M. Hollander, W. Lewis, S. Xie,J. Hadfield and M.S. Finkel. West Virginia Univ., Emory Univ.and LA Johnson VA Med. Ctr., Clarksburg, WV.C141 614.22 Endocytosis of SARS coronavirus spikeprotein. A-D.N. Fowajuh and C. Machamer. Univ. of MarylandEastern Shore and Johns Hopkins Univ. Sch. of Med.C142 614.23 Comparison of the life cycle and the survivalstrategies of two sand fl y vectors of leishmanaisis. M.L. Artis,C. Meneses and D-E. Elnaiem. Univ. of Maryland EasternShore and NIAID, NIH, Rockville.C143 614.24 Cloning of Streptococcus pyogenes ackand pta genes, and purifi cation and characterization of thecorresponding recombinant proteins L.M. Rivera, S. Agarwaland V. Pancholi. Univ. of Puerto Rico-Mayaguez Campus andOhio State Univ.615. PATHOBIOLOGY OF AGINGPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCAgingMiscellaneous Organ PathobiologyPresentation time: 11:30 AM-1:30 PMC144 615.1 FoxO1 is involved in the antineoplastic effectof calorie restriction. I. Shimokawa, T. Komatsu, R. Mori, H.Hayashi and T. Chiba. Nagasaki Univ. Grad. Sch. of Biomed.Sci.C145 615.2 Antifi brotic effects of dehydroepiandrosteronein lung fi broblasts in vitro. C.M. Milla, M. Montaño, A. Lozano,R. Chavira, A. Pardo and M. Selman. Natl. Inst. of Resp. Dis.Ismael Cosío Villegas, Natl. Inst. of Med. Sci. and Nutr. SalvadorZubirán and Natl. Autonomous Univ. of Mexico, Mexico City.C146 615.3 Human astrocytes exhibit an increasedexpression of the cellular senescence biomarker p16INK4a inaged human brain and Alzheimer’s disease. R. Bhat, M. Moh, A.Bitto, C. Sell, C. Katsetos, F.U. Garcia, J.Q. Trojanowski andC. Torres. Drexel Univ. Col. of Med. and Univ. of Pennsylvania.C147 615.4 A role for p21-activated-kinase 2 in vascularsmooth muscle cell senescence. H-e. Byeon, D-k. Rhee andS. Pyo. Sungkyunkwan Univ. Sch. of Pharm., South Korea.C148 615.5 Acrylamide induces cellular senescence inmacrophage through ROS-MAPK signaling pathway. K. Kim,D-K. Rhee and S. Pyo. Sungkyunkwan Univ. Sch. of Pharm.,South Korea.C149 615.6 Inhibition of NF-κB enhances the characteristicsof aged muscle stem cells. J.D. Proto, A. Lu and J. Huard.Univ. of Pittsburgh Sch. of Med.616. VASCULAR BIOLOGY AND PATHOBIOLOGYPosterPATHOLOGYSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCVascular BiologyMolecular PathologyPresentation time: 11:30 AM-1:30 PMC150 616.1 High density lipoprotein from patients withcoronary artery disease shows reduced binding and interactionwith human arterial endothelial cells. K.D. Navab, S. Safarpour,L. Vakili, M. Memarzadeh, J.B. Kim, O. Elboudwarej, S.Y.Hama, S. Vazirian and G. Hough. UCLA Geffen Sch. of Med.C151 616.2 Histopathological effects of ortaniquepeel polymethoxylated fl avones on organ structures ofhypercholesterolemic rats. C.O. Green, A.O. Wheatley, B.Hanchard, T. Gibson, D.A. McGrowder, L.L. Dilworth andH.N. Asemota. Univ. of West Indies, Jamaica.C152 616.3 Role of Toll-like receptor 4 in early intimal foamcell accumulation in apolipoprotein E-defi cient mice. D. Beasley,M. Higashimori, J.B. Tatro, K.J. Moore, M.E. Mendelsohnand J.B. Galper. Tufts Med. Ctr. and NYU Sch. of Med.C153 616.4 Protein kinase C delta (pkcδ) contributes toaneurysm development through JNK-mediated monocytechemoattractant protein 1 expression. C.A. Harberg, S.Morgan, D. Yamanouchi and B. Liu. Univ. of Wisconsin-Madison.C154 616.5 C-reactive protein polarizes humanmacrophages to an M1 phenotype. S. Devaraj and I. Jialal.Univ. of California, Davis Med. Ctr.C155 616.6 Statins synergize dexamethasone-inducedmacrophage aP2 expression — a dual glucocorticoid receptordependentmechanism. J. Han, W. Hu and X. Zhou. NankaiUniv., People’s Republic of China.C156 616.7 Loss of TDAG51 attenuates aorta smoothmuscle to osteoblast transdifferentiation and calcifi cation. I.Al-Bondokji, J.G. Dickhout, J. Krepinsky and R.C. Austin.McMaster Univ. and St. Joseph’s Healthcare, Hamilton,Canada.C157 616.8 The anti-infl ammatory cytokine IL-19 inducesHO-1 expression and decreases reactive oxygen species inhuman vascular smooth muscle cells. K. Gabunia, S. Kelemen,S. Ellison and M. Autieri. Temple Univ. Sch. of Med.C158 616.9 The anti-infl ammatory cytokine interleukin-19inhibits smooth muscle cell migration and activation ofcytoskeletal regulators of VSMC motility. K. Gabunia, S. Jain,R. England and M. Autieri. Temple Univ. Sch. of Med.C159 616.10 Fine balance between HIF1 and HIF2 insmooth muscle is crucial for normal development and survival.L. Lei, D. Liu, W. Jiang, Y. Huang and F. Giordano. Yale Univ.C160 616.11 Compound C inhibits vascular smooth musclecell proliferation in an AMPK-independent manner. W. Durante,Y. Yu, B. Yates, A.R. Shebib, X-m. Liu, H. Wang and K.J.Peyton. Univ. of Missouri-Columbia and Temple Univ.C161 616.12 ALK1 and Endoglin regulation of EphrinB2and sprout formation: potential relevance to HHT. J-H. Kim, M.Peacock and C.C. W. Hughes. Univ. of California, Irvine.C162 616.13 PP2A-mediated dephosphorylation ofeNOS and Erk2: a new molecular mechanism of impairedangiogenesis in experimental duodenal ulcer. X. Deng, X.Xiong, B. Paunovic, Z. Sandor and S. Szabo. VA Long BeachHealthcare Syst.177SUN