SUNDAY, APRIL 10 Across Societies â Experimental Biology

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BIOCHEMISTRYSUNDAY528. AGING AND METABOLISMPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:25 PM-1:55 PMB160 528.1 Bidirectional vitamin transport and themechanism of calorie restriction. C. Brenner. Univ. of Iowa.B161 528.2 Dietary glycine supplementation mimicslifespan extension by dietary methionine restriction in Fisher344 rats. J. Brind, V. Malloy, I. Augie, N. Caliendo, J.H.Vogelman, J.A. Zimmerman and N. Orentreich. Baruch Col.,CUNY, Orentreich Fndn. for Adv. of Sci. Inc., Cold Spring-on-Hudson, NY and St. John’s Univ., NY.B162 528.3 Klotho protects against oxidative stress throughantioxidant and apoptotic signaling pathways. R. Brobey, K-O.Makoto and K. Rosenblatt. Univ. of Texas Hlth. Sci. Ctr. atHouston and Univ. of Texas Southwestern Med. Ctr. at Dallas.B163 528.4 TIAF1 self-aggregation precedes amyloid betaformation in vivo. N-S. Chang. Natl. Cheng Kung Univ., Taiwanand SUNY Upstate Med. Univ.B164 528.5 The role of singlet oxygen in the UVA-inducedbystander effect on dermal fi broblasts. J.G. Gao, A. Shih andM. Simon. Stony Brook Univ.B165 528.6 Long-chain glycosphingolipids mediate renalaging. M. Hernandez-Corbacho, A.R. Mather, R. Jenkins, C.Clarke, Y. Hannun, L. Obeid, A. Snider and L. Siskind. Med.Univ. of South Carolina and Ralph H. Johnson VA Med. Ctr.B166 528.7 Modulation of mosquito lifespan by resveratrol.R.D. Nunes, D.M. Moretti, C.O. Cudischevitch, P.R.Bittencourt-Cunha, J. H.M. Oliveira, R.L. S. Gonçalves, D.S.Gusmão, D.S. Alviano, F.J. A. Lemos, G.C. Atella and M.A.C. Silva-Neto. Fed. Univ. of Rio de Janeiro and Univ. of NorthFluminense Province, Brazil.B167 528.8 The infl uence of p66Shc on whole body energymetabolism in mice. J.H. Stern, K. Hagopian, G.A. Cortopassiand J.J. Ramsey. Univ. of California, Davis.B168 528.9 Shared mechanisms in adenylyl cyclase type5 knockout and caloric restriction. L. Yan, J.Y. Park, M.S. DeLorenzo, H. Ge, L. Lai, B. Tian, J. Sadoshima, D.E. Vatnerand S.F. Vatner. UMDNJ, Newark.529. GLUCOLIPOTOXICITY AND METABOLICSTRESSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:25 PM-1:55 PMB169 529.1 NADPH oxidase 4 mediates metabolic stressinducedhyper-responsiveness of monocytes to MCP-1. C.F.Lee, Q. Zhao, S.L. Ullevig, H.S. Kim and R. Asmis. Univ. ofTexas Hlth. Sci. Ctr. at San Antonio.530. METABOLISM AND DIABETES IPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:25 PM-1:55 PMSee Metabolism and Diabetes II scheduled Monday.B170 530.1 Effect of artifi cial sweeteners on insulinsecretion, ROS, and oxygen consumption in pancreatic betacells A.M. Al-Saleh, B. Corkey, J. Deeney, K. Tornheim andE. Bauer. Boston Univ. Sch. of Med. and Rivers Sch., Weston,MA.B171 530.2 Altered O-GlcNAc modifi cation andphosphorylation of mitochondrial proteins in myoblast cellsexposed to high glucose. S.R. Ande, Y. Gu and S. Mishra.Univ. of Manitoba.B172 530.3 Effects of catalase overexpression on redoxbalance and insulin resistance in skeletal muscle cells. M.R.Barbosa, I. Sampaio, V. Casagrande, L. Parreiras-E-Silva, R.Reis, L.C. Alberici, E. Carneiro, R. Curi and L.D. R. Silveira.Univ. of São Paulo, Ribeirão Preto.B173 530.4 BIGH3: a new target in diabetic complications.J.M. Castaneda-Gill, S. Hardikar, M. Navarro, E. Kotchan,H.S. Kim, Q. Zhao, C.F. Lee, A. Tsin, R. Asmis and R.LeBaron. Univ. of Texas at San Antonio and Univ. of Texas Hlth.Sci. Ctr. at San Antonio.B174 530.5 Evaluation of the effectiveness of the insulinmimetics,selenium and vanadium, in insulin-resistance inprimary hepatocytes S. Coulibaly, K. McPherson, S. Nair, D.Ruff II and S.R. Stapleton. Western Michigan Univ.B175 530.6 Hexokinase and phosphofructokinase aspossible targets of insulin-independent cardioprotective actionof metformin. D. Da Silva, P.A. De Oliveira, W.S. Coelho, P.Zancan, E.M. de Alencar and M. Sola-Penna. Fed. Univ. ofRio de Janeiro.B176 530.7 Characterization of ATP10C and multiplesignaling pathway proteins in C2C12 cells using immunoblotassays and immunofl uorescence microscopy. S.E. Hurst,S. Minkin, J. Biggerstaff and M. Dhar. Univ. of Tennessee,Knoxville.B177 530.8 Benefi cial metabolic effects of conditionalactivation of Gq signaling in pancreatic β-cells. S. Jain, J-M.Guettier and J. Wess. NIDDK, NIH.B178 530.9 Regulation of cardiac oxidative stress and lipidperoxidation in streptozotocin-induced diabetic rats treated withaqueous extract of Pimpinella tirupatiensis tuberous root. S.R.Kesireddy, R.R. Saddala, L.T. Reddy and S.N. Ganapathi.Sri Venkateswara Univ., India.B179 530.10 Lack of PanK1 improves insulin sensitivity andglucose tolerance by activating AMPK in skeletal muscle. R.Leonardi, C.O. Rock and S. Jackowski. St. Jude Children’sRes. Hosp.B180 530.11 Effect of administration of Eryngium carlinaeon lipid profi le in diabetes. R. Noriega-Cisneros, C. Cortés-Rojo, E. Calderón-Cortés, M. Clemente-Guerrero, S. Manzo-Avalos and A. Saavedra-Molina. Univ. Michoacana of SanNicolás de Hidalgo, Mexico.146
SUNDAY531. MITOCHONDRIA-DERIVED SIGNALSPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 12:25 PM-1:55 PMB181 531.1 Mitochondria as autonomous sensors oftemperature fl uctuations. M.E. Glasheen, M-C.G. Marcondes,B. Conti and S.S. Ali. UCSD and San Diego VA Hosp. and TheScripps Res. Inst.532. FRONTIERS IN OBESITY RESEARCHPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB182 532.1 Mesenteric and omental depot differences in fattissue infl ammatory markers and signaling from type 2 diabeticand normal obese humans. T. Ghansah, M. Murr, J.E. Watson,S. Yoder, D. Fleming, N. Nelson, Y. Peng, A. Apostolatos, K.Gower, N.A. Patel and D.R. Cooper. Univ. of South Florida,James A Haley Veterans Hosp. and Moffi tt Cancer Ctr.B183 532.2 The plateau principle, a model of approach tosteady state for weight and metabolic functions after bariatricsurgery J.L. Hargrove, G. Heinz, J.W. Smith, J. Frediani, T.R.Ziegler, E. Lin and N. Gletsu-Miller. Univ. of Georgia, PrivateConsultant, Carmel, CA and Emory Univ. Sch. of Med.B184 532.3 Regulation of peroxisome proliferator-activatedreceptorγ, caspase 9b, and PKCβII alternative splicing by Clk1kinase in 3T3-L1 preadipocytes P. Li, J. Romero, K. Gower,J.E. Watson, G. Carter, H. Apostolatos, S. Yoder, T. Ghansah,N.A. Patel and D.R. Cooper. Univ. of South Florida, JA HaleyVA Hosp. and Moffi tt Cancer Ctr., Tampa.B185 532.4 Myeloperoxidase and fat tissue deregulationduring obesity. D.C. Ramirez and S.E. Gomez-Mejiba.Oklahoma Med. Res. Fndn.533. DISPARITIES IN OBESITYPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMB186 533.1 Adipocyte and adipose tissue gene expressionin subjects with different body mass indexes with and withoutinsulin resistance. A. Serralde, A.R. Tovar, I. Medina-Vera, L.Gil-Zenteno and N. Torres. Natl. Inst. of Med. Sci. and Nutr.Salvador Zubirán, Mexico City.534. OBESITY AND THE METABOLIC SYNDROMEPosterSUN. 7:30 AM—WASHINGTON CONVENTION CENTER, EXHIBITHALL ABCPresentation time: 1:05 PM-2:35 PMBIOCHEMISTRYB187 534.1 Regulation of de novo lipid synthesis by smallorganic molecules, fatostatins L. Abu-Elheiga, M. Uesugi andS. Wakil. Baylor Col. of Med. and Kyoto Univ.B188 534.2 Inhibition of SCD activity in RAW264.7macrophages promotes endoplasmic reticulum stress responsebut decreases lipogenesis while enhancing cholesteroltraffi cking. Z. Akhtar, X. Liu and J. Ntambi. Univ. of Wisconsin-Madison.B189 534.3 Hypertrophic adipocytes decreased insulinsensitivity due to lipid dysregulation. J.I. Kim, J.Y. Huh andJ.B. Kim. Seoul Natl. Univ.B190 534.4 The increased expression of PPARγ isresponsible for the fatty acid transport and lipid accumulation indiet-induced hepatic steatosis. Y.J. Lee, E.H. Ko, J. Pang, S.W.Park and J-W. Kim. Yonsei Univ. Col. of Med., South Korea.B191 534.5 The effect of FXR ligands on fatty liver modelof cultured cells. T. Miyazaki, A. Honda, T. Ikegami, M. Shiraiand Y. Matsuzaki. Tokyo Med. Univ.B192 534.6 Effects of estrogen and leptin on hypothalamicagouti-related peptide/neuropeptide Y synaptic density. C.E.Okona, J. Newton and A.W. Xu. Oberlin Col. and UCSF.B193 534.7 Development of high-fat diet-induced obesityand hepatic infl ammation in NEIL1 defi cient mice. H. Sampath,A. Batra, V. Vartanian, J.R. Carmical, D. Prusak, I.B. King, B.Lowell, L.F. Earley, T.G. Wood, D.L. Marks, A.K. McCulloughand R.S. Lloyd. Oregon Hlth. & Sci. Univ., Univ. of Texas Med.Branch and Univ. of New Mexico.B194 534.8 Brown adipocyte activation is characterizedby a wave of mitochondrial fi ssion and depolarization thatis dependent on β3 receptor stimulation and Drp1, and ischaracterized by complete, but reversible, arrest of fusionS. Sereda, J. Wikstrom, Y. Si, G. Twig, M. Liesa, G. Las, B.Cannon, J. Nedergaard and O. Shirihai. Boston Univ. andStockholm Univ.B195 534.9 Increased production of the adipocyte hormoneadiponectin in mice lacking neutrophil cytosolic factor 1. M.Shtayer, M. Nunez, G. Chen, C. Stump and T-S. Tsao. Univ.of Arizona, Univ. of Arizona Hlth. Sci. Ctr. and Southern ArizonaVA Hlth. Care Syst.B196 534.10 Identifi cation of new molecular componentsin the GLUT4 clusters in the plasma membrane of adiposecells by mass spectrometry-based proteomics. J. Yang, X. Xie,D.E. Anderson, K.G. Stenkula, D. Yver, C. Meyer and S.W.Cushman. NIDDK, NIH, Univ. of South Alabama Col. of Med.and Arizona State Univ.SUN147
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SUNDAY, APRIL 10 Across Societies â Experimental Biology