Perfusion fMRI - Center for Functional MRI

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Arterial Spin Labeling •Magnetically tag inflowing arterial blood •Wait <strong>for</strong> tagged blood to flow into imaging slice •Acquire image of tissue+tagged blood •Apply control pulse that doesn’t tag blood •Acquire control image of tissue •Control image-tag image = blood image
Methods <strong>for</strong> Tagging Arterial Blood •Spatially Selective ASL (SS-ASL) methods tag arterial blood in a region that is proximal to the imaging region of interest. • Continuous ASL (CASL) -- continuously tags blood as it passes through a thin tagging plane • Pulsed ASL (PASL) -- tags blood in a large slab proximal to imaging slice. •Velocity Selective ASL (VS-ASL) tags arterial blood based on its velocity, and takes advantage of the fact that blood decelerates as it enters the capillaries and accelerates as it enters the veins.
Page 1 and 2: Perfusion fMRI Thomas Liu Center fo
Page 3 and 4: Cerebral Blood Flow (CBF) CBF = Per
Page 5: High CBF Low CBF Time
Page 9 and 10: Arterial Spin Labeling (ASL) • wa
Page 11 and 12: Continuous ASL Imaging Plane Invers
Page 13 and 14: Multislice CASL and PICORE CASL PIC
Page 16: Major Sources of Error for ASL •
Page 19 and 20: Arterial Bolus Width CASL Baseline
Page 22 and 23: Velocity Selective ASL •Velocity
Page 24 and 25: Ideal Velocity Selective ASL 1 Cont
Page 26 and 27: Initial Implementation (2002) 90 x
Page 28 and 29: Results - VENC Dependence VENC (cm/
Page 30 and 31: Future Development of VS-ASL • Be
Page 32 and 33: Pairwise subtraction example Contro
Page 34 and 35: ASL Data Processing • BOLD = aver
Page 36 and 37: Simultaneous Flow and BOLD with PAS
Page 38 and 39: Event-related ASL • ASL time seri
Page 40 and 41: Results Direct Running Subtraction
Page 42 and 43: Non-quantitative ASL • ASL signal
Page 44 and 45: Finger Tapping PICORE Turbo PICORE
Page 46 and 47: Amplifying Transit Delays Effects i
Page 48 and 49: Close Tag CASL Subject 1 Subject 2
Page 50 and 51: CBF and BOLD with Eyes Open/Closed
Page 52 and 53: ASL Mapping of Cortical Columns in
Page 54 and 55: Overview of BOLD Mechanisms Neurona
Page 56 and 57:
Conclusions • ASL provides a non-
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Perfusion fMRI - Center for Functional MRI

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