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Congress Abstracts full PDF - International Council of Medical ...

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THE EFFECTS OF BAICKBUJASAN EXTRACT ON THE SKIN DAMAGE AND PIGMENDATION INDUCED BY<br />

ULTRAVIOLET IRRADIATION<br />

Seung-Ug Hong, Ji-Hoon Kim<br />

Dongguk University, South Korea<br />

Objective: The purpose <strong>of</strong> this study is to examine the effects <strong>of</strong> Baickbujasan(BB) on depigmentation.<br />

Method: The inhibition <strong>of</strong> tyrosinase activity, melanogenesis and cell viability in cultured B16 melanoma cells were<br />

measured. In order to test effects <strong>of</strong> reduction <strong>of</strong> melanogenesis, B16 F-10 mouse melanoma stem line was employed<br />

to extract melanin from cultured cell, where BB was added or not, was dissolved in alkali for colorimetric analysis.<br />

Also, in order to test skin alteration in C57BL/6 after UV irradiation, the animals were grouped into a UV urradiation<br />

group and UV irradiation after BB application group. Dopa oxidase tissue staining was excuted to invesitage the<br />

change in the distribution <strong>of</strong> active melanin cell. The distribution <strong>of</strong> active melanin cell in inner skin <strong>of</strong> iNOS after<br />

damage from UVB irradiation and the manifestation condition <strong>of</strong> P53 which takes part in natural death <strong>of</strong> keratinocyte<br />

were examined.<br />

Result: The results indicate that BB has significant effects on tyrosinase activity, and melanogenesis in vivo test.<br />

BB seems to reduce C57BL/6, external dermatological damage, for instance, erythematous papule, eczema, loss <strong>of</strong><br />

keratinocyte, reduction in pus, and relieves dermatological damages.<br />

Conclusion: BB can be applied externally for UV protection and depigmentation.<br />

Key words: Tyrosinase, melanogenesis, UVB, iNOS, p53, Baickbujasan<br />

RISK FACTOR ANALYSIS OF NEEDLE SICKNESS<br />

Tse-Hung Huang 1 , Heng-Hong Chang 2,3, *<br />

1<br />

Division <strong>of</strong> Acupuncture-Moxibustion and Traumatology, 2 Center for Traditional Chinese Medicine, Chang Gung<br />

Memorial Hospital, 3 Graduate Institute <strong>of</strong> Traditional Chinese Medicine, Chang Gung University, *Corresponding<br />

author<br />

Acupuncture is well known worldwide since 1972. In the common understanding, acupuncture seems to be safe<br />

without any adverse effect. However, almost every clinical practitioner <strong>of</strong> acupuncture had encountered needle<br />

sickness on patients. According to the study <strong>of</strong> Edzard Emst, commonly seen adverse effects <strong>of</strong> acupuncture included<br />

pain (1-45%), fatigue (2-41%), bleeding (0.03-38%), and needle sickness(0.03-38%). In Taiwan, the adverse effects<br />

<strong>of</strong> acupuncture are increasing due to the prevalent application <strong>of</strong> acupuncture. In this study, cases <strong>of</strong> needle sickness<br />

were recorded in a 2-year-study in the acupuncture departments <strong>of</strong> a teaching hospital in Taiwan. Patients <strong>of</strong> needle<br />

sickness were reported with demographical characteristics (including sex, age, body weight, height, blood type,<br />

menstrual cycles, marriage, education, occupation, and income), previous history <strong>of</strong> acupuncture and previous<br />

adverse effects, current and previous medication history, and quality <strong>of</strong> life index. The risk factors <strong>of</strong> needle sickness<br />

were screened by mon<strong>of</strong>actor and multifactor analysis. In the result, the frequency <strong>of</strong> needle sickness was 0.001.<br />

There was no significant difference in sex. The most common age <strong>of</strong> patients with needle sickness was 20-40 years<br />

old. Statistical significances were noted in previous history <strong>of</strong> needle sickness, first ever experience <strong>of</strong> acupuncture,<br />

fear <strong>of</strong> acupuncture, current use <strong>of</strong> antihypertensive medication (including, beta-blocker, angiotensin converting<br />

enzyme inhibitor, and calcium channel blocker), medication <strong>of</strong> muscle relaxant, and medical history <strong>of</strong> vertigo. After<br />

education to the patients with history <strong>of</strong> needle sickness, patients continuously receiving acupuncture in the following<br />

year showed >50% decrease <strong>of</strong> the frequency <strong>of</strong> needle sickness. In summary, the risk factors <strong>of</strong> needle sickness<br />

based on this study were: 1. First ever experience <strong>of</strong> acupuncture, 2. History <strong>of</strong> needle sickness, 3. Cardiovascular<br />

disease with current medication <strong>of</strong> antihypertensive medication, 4. With fear <strong>of</strong> acupuncture, 5. History <strong>of</strong> vertigo.<br />

According to the listed risk factor, screening patients with high risk <strong>of</strong> needle sickness and informing and educating<br />

the high risk patients before acupuncture effectively prevent the occurring <strong>of</strong> needle sickness.<br />

Key word: Needle sickness, needle fainting, adverse effect, acupuncture, risk factor, epidemiology<br />

THE RELATIONSHIP BETWEEN HEGU (L14) AND YINGXIANG (L12)<br />

Yoh Ichimura, Ikuemon Katayama<br />

Meikai University<br />

Introduction & Aim <strong>of</strong> the study: This study we made investigation into the relationship between side to side<br />

Huge (LI4) and Yingxiang (LI2). In addition, we compared the effects <strong>of</strong> a laser needle with those <strong>of</strong> standard needles<br />

with regard to acupuncture treatment.<br />

Methods: Subjects were 5 volunteers who underwent treatment at the Hegu with the acupuncture and the carbondioxide<br />

laser needle having an energy density <strong>of</strong> 10.4 J/cm2. At 5 and 10 minutes after irradiation, we measured<br />

surface temperatures at the Yingxiang using thermograpy. At 50 minutes after laser irradiation, the volunteers<br />

80

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