Thyroid gland
Thyroid gland
Thyroid gland
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4. EXOCYTOSIS<br />
Excytosis of thyreoglobulin into the colloid<br />
5. Iodination<br />
MIT, DIT<br />
TSH<br />
6. CONJUGATION (COUPLING)<br />
DIT + DIT = T4 + ALANINE<br />
MIT + DIT = T3 + ALANINE<br />
TSH<br />
7. PINOCYTOSIS OF THE COLLOID<br />
Iodinated thyreoglobulin is the thyroid hormone store in the colloid.<br />
(sufficient for 2 weeks)<br />
1/4 MIT, 1/3 DIT, 1/3 T4, + T3<br />
TSH stimulated process<br />
8. PROTEOLYSIS<br />
TSH<br />
Proteolysis of thyreoglobulin in lysosomes - phagolysosomes<br />
release of T3 [10%] und T4 [90%].<br />
9. DEIODINATION (deiodinases)<br />
TSH<br />
10. SECRETION<br />
TSH
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