Relationship of Glycemia to Cardiovascular Disease ... - Lipids Online

TNT Study: Impact of Glucometabolic
Characteristics on Risk of Major
Cardiovascular Events Among All Patients
Patients with Major
Cardiovascular Event (%)
16
12
8
4
0
Low
High-Density
Lipoprotein
Characteristic Absent
Characteristic Present
HR = 1.33
HR = 1.30
Fasting
Glucose
100 mg/dL
HR = 1.24 HR = 1.18 HR = 1.48
Body-Mass
Index
28 kg/m 2
Triglycerides
250 mg/dL
Hypertension
TNT = Treating to New Targets study
Reprinted from Deedwania P, et al. Lancet. 2006;
368:919–928, with permission from Elsevier.
Slide Source
Lipids Online Slide Library
www.lipidsonline.org
TNT Study: Impact of Glucometabolic Characteristics on Risk of Major
Cardiovascular Events Among All Patients
The factors associated with residual risk are the criteria commonly used to make a
diagnosis of metabolic syndrome. According to the Treating to New Targets study,
patients who have low levels of high-density lipoprotein, a fasting glucose >100 mg/dL,
obesity, hypertriglyceridemia, and hypertension are placed at risk despite the lowering of
low-density lipoprotein with high-dose atorvastatin. These 5 factors could then represent
additional targets for intervention with the hope that some of the residual risk could be
reduced. At present, attention has been directed to the possibility that an intervention that
lowers fasting glucose could remove some of this residual risk.
Reference:
Deedwania P, Barter P, Carmena R, et al, for the Treating to New Targets Investigators.
Reduction of low-density lipoprotein cholesterol in patients with coronary heart disease
and metabolic syndrome: analysis of the Treating to New Targets study. Lancet.
2006;368:919-928.
Source: Lipids Online Slide Library (www.lipidsonline.org) Page 3 of 36
© 2009 Baylor College of Medicine, Houston, Texas