Relationship of Glycemia to Cardiovascular Disease ... - Lipids Online

Controlling Postprandial Hyperglycemia Leads to Regression of
Carotid Atherosclerosis in Patients With Type 2 Diabetes Mellitus
Repaglinide Glyburide
1.4
*P = 0.01
Postprandial Postprandial 1.3
260
Peak
Peak
1.2
P 0.001 P 0.01
220
1.1
*
180
1.0
*
140
0.9
100
Before After Before After
0.8
260
0.7
220
0.6
180
0.5
140
0.4
100
P 0.001 P 0.01
0
Before After Before After
0 60 120 0 60 120
Minutes
Repaglinide Glyburide
Glucose (mg/dL)
Carotid Intima-Media Thickness
(mm)
C-IMT Regression Associated With PPG, IL-6, and CRP
C-IMT = carotid intima-media thickness; PPG = postprandial glucose; IL-6 = interleukin 6;
CRP = C-reactive protein
Reprinted from Esposito K, et al. Circulation. 2004;110:214–219,
with permission from Lippincott Williams & Wilkins.
Slide Source
Lipids Online Slide Library
www.lipidsonline.org
Controlling Postprandial Hyperglycemia Leads to Regression of Atherosclerosis in
Patients With Type 2 Diabetes Mellitus
Esposito et al. (2004) investigated repaglinide, a prandial secretagogue, as a strategy for
reducing postprandial hyperglycemia in patients with type 2 diabetes mellitus. Patients
enrolled in the study were randomized to receive either repaglinide or glyburide. Those
who received repaglinide had a reduction in the progression of carotid intima-media
thickness when compared to those who received glyburide. The data from this study
would support the findings of the STOP-NIDDM trial (previous slide).
Reference:
Esposito K, Giugliano D, Nappo F, Marfella R, for the Campanian Postprandial
Hyperglycemia Study Group. Regression of carotid atherosclerosis by control of
postprandial hyperglycemia in type 2 diabetes mellitus. Circulation. 2004;110:214-219.
Source: Lipids Online Slide Library (www.lipidsonline.org) Page 8 of 36
© 2009 Baylor College of Medicine, Houston, Texas