Invasion and metastasis - Experimental Oncology Graduate Study

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If the metastatic phenotype arises early then most tumors will have already metastasized by the time of detection Consensus: most tumors do metastasize early <strong>and</strong> give rise to micrometastases that are too small to detect. Aggressive therapy given soon after detection of primary may therefore reduce the incidence of metastatic disease.
How do tumors spread? The concept of the invasion-<strong>metastasis</strong> cascade: 6 distinct steps Probability of an individual cancer cell completing cascade is very small
Page 1 and 2: Invasion and Metastasis
Page 3 and 4: Cell 144, March 4, 2011 p 646-674 2
Page 9 and 10: Metastatic disease non Hodgkins Lym
Page 11 and 12: Metastases disrupt organ functions
Page 13: If larger tumors associated with in
Page 17 and 18: More typically cells invade as a po
Page 19 and 20: Step 2 Intravasation: transport thr
Page 21 and 22: Routes of circulation Tumors usuall
Page 23 and 24: Tumors attach to vessel walls thro
Page 25 and 26: How efficient is metastasis? Mice c
Page 27 and 28: Evolution of metastatic ability can
Page 29 and 30: Micrometastases (MM) detectable in
Page 31 and 32: Can MM remain dormant? Are MM truly
Page 33 and 34: Epithelial-mesenchymal transition (
Page 35 and 36: Embryogenesis and EMT Ectodermal-me
Page 38 and 39: β-catenin translocates to nuclei
Page 40 and 41: Confirmation by immunoblot
Page 42 and 43: HGF (stromal factor) induces scatte
Page 44 and 45: Why do 2ndary tumors resemble prima
Page 46 and 47: How do stromal cells control EMT? R
Page 49 and 50: Signals that trigger EMT
Page 51 and 52: Transient expression Slug in wound
Page 53 and 54: Similarities between EMT embryogene
Page 55 and 56: Podosomes and focal degradation of
Page 57 and 58: Rho-C and metastasis (epithelial mo
Page 59 and 60: Metastatic tropisms-seed and soil o
Page 61 and 62: Metastasis to bone (osteotropic met
Page 63: Are there metastasis genes?
Page 67 and 68:
Cell 147: October 14 2011 p275-292
Page 69 and 70:
Science 25 March 2011: Vol. 331 no.
Page 71 and 72:
Cell 144, March 4, 2011 p 646-674 2
Page 76 and 77:
Leading Edge Review Tumor Metastasi
Page 78:
Hallmarks of Cancer: The Next Gener
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Invasion and metastasis - Experimental Oncology Graduate Study

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