Invasion and metastasis - Experimental Oncology Graduate Study

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EMT Upper panel: Epithelial cells in monolayer culture exposed to metalloproteinase MMP-3. Cells lose cytokeratins (red) and E-cadherin and acquire vimentin (green) fibronectin and N-cadherin become motile and invasive. Become indistinguishable from mesenchyme. Lower panel: Wounding MCF10A (pre-malignant) monolayer –induction of vimentin (red) at wound site. Vimentin lost once cells revert to epithelial.
Embryogenesis and EMT Ectodermal-mesodermal transition at gastrulation Delamination neuroepithelial cells from neural tube to form melanocytes, peripheral NS
Page 1 and 2: Invasion and Metastasis
Page 3 and 4: Cell 144, March 4, 2011 p 646-674 2
Page 9 and 10: Metastatic disease non Hodgkins Lym
Page 11 and 12: Metastases disrupt organ functions
Page 13 and 14: If larger tumors associated with in
Page 15 and 16: How do tumors spread? The concept o
Page 17 and 18: More typically cells invade as a po
Page 19 and 20: Step 2 Intravasation: transport thr
Page 21 and 22: Routes of circulation Tumors usuall
Page 23 and 24: Tumors attach to vessel walls thro
Page 25 and 26: How efficient is metastasis? Mice c
Page 27 and 28: Evolution of metastatic ability can
Page 29 and 30: Micrometastases (MM) detectable in
Page 31 and 32: Can MM remain dormant? Are MM truly
Page 33: Epithelial-mesenchymal transition (
Page 38 and 39: β-catenin translocates to nuclei
Page 40 and 41: Confirmation by immunoblot
Page 42 and 43: HGF (stromal factor) induces scatte
Page 44 and 45: Why do 2ndary tumors resemble prima
Page 46 and 47: How do stromal cells control EMT? R
Page 49 and 50: Signals that trigger EMT
Page 51 and 52: Transient expression Slug in wound
Page 53 and 54: Similarities between EMT embryogene
Page 55 and 56: Podosomes and focal degradation of
Page 57 and 58: Rho-C and metastasis (epithelial mo
Page 59 and 60: Metastatic tropisms-seed and soil o
Page 61 and 62: Metastasis to bone (osteotropic met
Page 63: Are there metastasis genes?
Page 67 and 68: Cell 147: October 14 2011 p275-292
Page 69 and 70: Science 25 March 2011: Vol. 331 no.
Page 71 and 72: Cell 144, March 4, 2011 p 646-674 2
Page 76 and 77: Leading Edge Review Tumor Metastasi
Page 78: Hallmarks of Cancer: The Next Gener

Invasion and metastasis - Experimental Oncology Graduate Study

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