Invasion and metastasis - Experimental Oncology Graduate Study

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Leading Edge Review Tumor Metastasis: Molecular Insights <strong>and</strong> Evolving Paradigms Scott Valastyan1,2,4,* <strong>and</strong> Robert A. Weinberg1,2,3,* Cell 147: October 14 2011 p275-292
Science 25 March 2011: Vol. 331 no. 6024 pp. 1559-1564 DOI: 10.1126/science.1203543 REVIEW: A Perspective on Cancer Cell Metastasis Christine L. Chaffer1,3,* Robert A. Weinberg1,2,3,*
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Invasion and Metastasis
Page 3 and 4:
Cell 144, March 4, 2011 p 646-674 2
Page 9 and 10:
Metastatic disease non Hodgkins Lym
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Metastases disrupt organ functions
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If larger tumors associated with in
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How do tumors spread? The concept o
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More typically cells invade as a po
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Step 2 Intravasation: transport thr
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Routes of circulation Tumors usuall
Page 23 and 24: Tumors attach to vessel walls thro
Page 25 and 26: How efficient is metastasis? Mice c
Page 27 and 28: Evolution of metastatic ability can
Page 29 and 30: Micrometastases (MM) detectable in
Page 31 and 32: Can MM remain dormant? Are MM truly
Page 33 and 34: Epithelial-mesenchymal transition (
Page 35 and 36: Embryogenesis and EMT Ectodermal-me
Page 38 and 39: β-catenin translocates to nuclei
Page 40 and 41: Confirmation by immunoblot
Page 42 and 43: HGF (stromal factor) induces scatte
Page 44 and 45: Why do 2ndary tumors resemble prima
Page 46 and 47: How do stromal cells control EMT? R
Page 49 and 50: Signals that trigger EMT
Page 51 and 52: Transient expression Slug in wound
Page 53 and 54: Similarities between EMT embryogene
Page 55 and 56: Podosomes and focal degradation of
Page 57 and 58: Rho-C and metastasis (epithelial mo
Page 59 and 60: Metastatic tropisms-seed and soil o
Page 61 and 62: Metastasis to bone (osteotropic met
Page 63: Are there metastasis genes?
Page 67 and 68: Cell 147: October 14 2011 p275-292
Page 69 and 70: Science 25 March 2011: Vol. 331 no.
Page 71 and 72: Cell 144, March 4, 2011 p 646-674 2
Page 78: Hallmarks of Cancer: The Next Gener
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Invasion and metastasis - Experimental Oncology Graduate Study

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