Invasion and metastasis - Experimental Oncology Graduate Study

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Does marrow micrometastasis predict relapse? Patients with MM at time of surgery have higher relapse rates. Breast cancer MM increase risk of developing metastatic disease 4 to 10 fold. Colon cancer patients 90% patients who lack MM alive at 15 months compared to 30% of those with marrow MM Cancer esophagus – 79-88% pts have MM in rib marrow at resection
Can MM remain dormant? Are MM truly dormant? Fluorescently-labeled cells lose fluorescence with each division. Breast cancer cells injected into portal vein lodge in liver were viable and had not lost fluorescence 11 weeks later. Cells could be excised, cultured and retained tumorigenicity when introduced subcutaneously. Cells were resistant to chemotherapy that killed growing cells.
Page 1 and 2: Invasion and Metastasis
Page 3 and 4: Cell 144, March 4, 2011 p 646-674 2
Page 9 and 10: Metastatic disease non Hodgkins Lym
Page 11 and 12: Metastases disrupt organ functions
Page 13 and 14: If larger tumors associated with in
Page 15 and 16: How do tumors spread? The concept o
Page 17 and 18: More typically cells invade as a po
Page 19 and 20: Step 2 Intravasation: transport thr
Page 21 and 22: Routes of circulation Tumors usuall
Page 23 and 24: Tumors attach to vessel walls thro
Page 25 and 26: How efficient is metastasis? Mice c
Page 27 and 28: Evolution of metastatic ability can
Page 29: Micrometastases (MM) detectable in
Page 33 and 34: Epithelial-mesenchymal transition (
Page 35 and 36: Embryogenesis and EMT Ectodermal-me
Page 38 and 39: β-catenin translocates to nuclei
Page 40 and 41: Confirmation by immunoblot
Page 42 and 43: HGF (stromal factor) induces scatte
Page 44 and 45: Why do 2ndary tumors resemble prima
Page 46 and 47: How do stromal cells control EMT? R
Page 49 and 50: Signals that trigger EMT
Page 51 and 52: Transient expression Slug in wound
Page 53 and 54: Similarities between EMT embryogene
Page 55 and 56: Podosomes and focal degradation of
Page 57 and 58: Rho-C and metastasis (epithelial mo
Page 59 and 60: Metastatic tropisms-seed and soil o
Page 61 and 62: Metastasis to bone (osteotropic met
Page 63: Are there metastasis genes?
Page 67 and 68: Cell 147: October 14 2011 p275-292
Page 69 and 70: Science 25 March 2011: Vol. 331 no.
Page 71 and 72: Cell 144, March 4, 2011 p 646-674 2
Page 76 and 77: Leading Edge Review Tumor Metastasi
Page 78: Hallmarks of Cancer: The Next Gener

Invasion and metastasis - Experimental Oncology Graduate Study

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