An Introduction to Medicinal Chemistry

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Drug dose levels 115 can easily negotiate the fatty cell membranes get mopped up by fat tissue or are too weak to bind to their receptor sites. Consequently,
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An Introduction to Medicinal Chemis
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Preface This text is aimed at under
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Contents Classification of drugs xi
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Contents
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Contents xi 11.16.2 Structure
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Classification of drugs
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1 • Drugs and the medicinal chemi
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Whilst penicillin Drugs and the med
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Drugs
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10 The why and the wherefore Cytopl
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Where do drugs work? 13 Amphoterici
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16 Protein structure [ H O
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The tertiary structure of proteins
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The tertiary structure of proteins
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24 Protein structure H-Bond Peptide
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26 Protein structure again that ter
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Substrate binding
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Substrate binding at an active site
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Substrate binding
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R The catalytic role of enzymes Thy
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I NH 2 CHO (OH Condensation R< The
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Nerve Neurotransmitters
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Receptors
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52 Drug action at receptors Induced
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54 Drug action at receptors MESSENG
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56 Drug action at receptors RECEPTO
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60 Drug action at receptors left-ha
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62 Drug action
Page 76 and 77: 64 Drug action
Page 78 and 79: 66 Drug action at receptors D Neuro
Page 81 and 82: Structure of DNA 69 NH 2 NHo NHo Ad
Page 83 and 84: Structure
Page 85 and 86: Drugs acting
Page 87: Drugs acting on DNA 75 CH3—N: MEC
Page 90 and 91: 78 Nucleic acids end AMINO «A/* Ba
Page 93: Summary 81
Page 96 and 97: 84 Drug development
Page 98 and 99: 86 Drug development | | Potential I
Page 100 and 101: 88 Drug development bonding or not,
Page 102 and 103: 90 Drug development 7.5.1 Variation
Page 104 and 105: 92 Drug development covered
Page 106 and 107: 94 Drug development avoiding patent
Page 108 and 109: 96 Drug development ,OH OH GLIPINE
Page 111: Receptor theories
Page 115 and 116: Lead compounds
Page 117 and 118: A case study—oxamniquine
Page 119 and 120: A case study—oxamniquine
Page 121 and 122: A case study—oxamniquine 109 CH 3
Page 124 and 125: 112 Pharmacodynamics stream. Thirdl
Page 128 and 129: 116 Pharmacodynamics Drugs
Page 130 and 131: 118 Pharmacodynamics Other common m
Page 132 and 133: 120 Pharmacodynamics
Page 134 and 135: 122 Pharmacodynamics Me AZATHIOPRIN
Page 136 and 137: 124 Pharmacodynamics Many peptides
Page 138 and 139: 126 Pharmacodynamics 8.3.9 Self-des
Page 141 and 142: Graphs and equations 129 What are t
Page 143 and 144: Physicochemical properties
Page 151 and 152: Meta Hydroxyl Group Physicochemical
Page 153 and 154: Quantifying steric properties Hansc
Page 155 and 156: log [I] The Craig plot 143
Page 157 and 158: The Topliss scheme 145 and electron
Page 159 and 160: The Topliss scheme 147 with a negat
Page 161 and 162: Planning
Page 163 and 164: Case study
Page 168: 156 Antibacterial agents prontosil
Page 171: Antibacterial agents which
Page 174 and 175: 162 Antibacterial agents MeO OMe Fi
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164 Antibacterial agents Fig. 10.15
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166 Antibacterial agents drug would
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168 Antibacterial agents -CH2- R—
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170 Antibacterial agents • Ineffe
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Antibacterial agents which inhibit
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groups Antibacterial agents which i
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186 Antibacterial agents = CH 3 C0
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188 Antibacterial agents Second- an
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192 Antibacterial agents
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194 Antibacterial agents [Normal Me
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196 Antibacterial agents L-Valine M
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198 Antibacterial agents L-LEU —
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200 Antibacterial agents which was
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202 Antibacterial agents o ,CO2H HN
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204 Antibacterial agents transferre
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206 The peripheral nervous system y
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208 The peripheral nervous system S
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210 The peripheral nervous system N
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212 The peripheral nervous system 1
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Agonists at the cholinergic recepto
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Water Design of acetylcholine analo
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Design
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224 The peripheral nervous system H
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A large variety Antagonists of the
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Antagonists
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Antagonists
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drug design Other cholinergic antag
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Anticholinesterases
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Anticholinesterase drugs 239 - Pyrr
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242 The peripheral nervous system M
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244 The peripheral nervous system F
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N—CH 3 MeO. R'O* R
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Morphine 249 12.2 Morphine 12.2.1 S
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Morphine 253 To conclude, the 6-hyd
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Development
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Development of morphine analogues 2
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Development
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Development
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270 The opium analgesics analgesic
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272 The opium analgesics acts as a
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Enkephalins
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278 The opium analgesics narcotic a
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280 The opium analgesics O II N —
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Searching
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Searching for a lead—AT-guanylhis
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Developing the lead—a chelation b
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Development of metiamide 295 meanin
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Development
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Further studies—cimetidine analog
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Famotidine and nizatidine 309 • R
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Appendix
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(vesicles) containing The action of
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The action of nerves 319 x Briv "-
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Secondary messengers
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Secondary messengers 323 the proces
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Appendix 4 • Bacteria and bacteri
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Glossary ADDICTION Addiction can be
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Further reading Albert,
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drug addiction 1, 3, 5, 127, 248, 2
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penillic acids 172 pentagastrin Ind
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An Introduction to Medicinal Chemistry

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