An Introduction to Medicinal Chemistry

More documents

Recommendations

Info

190 Antibacterial agents Fig. 10.54 Clavulanic acid as an irreversible mechanism based inhibitor. Plays a role in 6-lactamase •< resistance Acylamino side Opposite chain ^fcsent stereochemistry OH i to penicillins H N / Carbon / H / i^^--\ H 3 C^'***', ' // ) ——— S " N-*^/^ C0 2© Carbapenam nucleus Fig. 10.55 Thienamycin. Double bond leading
Antibacterial agents which inhibit cell wall synthesis 191 Olivanic acids The olivanic acids (e.g. MM13902) (Fig. 10.56) were isolated from strains of Streptomyces olivaceus
Page 1 and 2:
An Introduction to Medicinal Chemis
Page 3 and 4:
Preface This text is aimed at under
Page 5 and 6:
Contents Classification of drugs xi
Page 7 and 8:
Contents
Page 9 and 10:
Contents xi 11.16.2 Structure
Page 11 and 12:
Classification of drugs
Page 13 and 14:
1 • Drugs and the medicinal chemi
Page 15 and 16:
Whilst penicillin Drugs and the med
Page 17:
Drugs
Page 22 and 23:
10 The why and the wherefore Cytopl
Page 25:
Where do drugs work? 13 Amphoterici
Page 28:
16 Protein structure [ H O
Page 31 and 32:
The tertiary structure of proteins
Page 33 and 34:
The tertiary structure of proteins
Page 36 and 37:
24 Protein structure H-Bond Peptide
Page 38:
26 Protein structure again that ter
Page 43 and 44:
Substrate binding
Page 45 and 46:
Substrate binding at an active site
Page 47:
Substrate binding
Page 53 and 54:
R The catalytic role of enzymes Thy
Page 55 and 56:
I NH 2 CHO (OH Condensation R< The
Page 59 and 60:
Nerve Neurotransmitters
Page 61 and 62:
Receptors
Page 64 and 65:
52 Drug action at receptors Induced
Page 66 and 67:
54 Drug action at receptors MESSENG
Page 68:
56 Drug action at receptors RECEPTO
Page 72 and 73:
60 Drug action at receptors left-ha
Page 74 and 75:
62 Drug action
Page 76 and 77:
64 Drug action
Page 78 and 79:
66 Drug action at receptors D Neuro
Page 81 and 82:
Structure of DNA 69 NH 2 NHo NHo Ad
Page 83 and 84:
Structure
Page 85 and 86:
Drugs acting
Page 87:
Drugs acting on DNA 75 CH3—N: MEC
Page 90 and 91:
78 Nucleic acids end AMINO «A/* Ba
Page 93:
Summary 81
Page 96 and 97:
84 Drug development
Page 98 and 99:
86 Drug development | | Potential I
Page 100 and 101:
88 Drug development bonding or not,
Page 102 and 103:
90 Drug development 7.5.1 Variation
Page 104 and 105:
92 Drug development covered
Page 106 and 107:
94 Drug development avoiding patent
Page 108 and 109:
96 Drug development ,OH OH GLIPINE
Page 111:
Receptor theories
Page 115 and 116:
Lead compounds
Page 117 and 118:
A case study—oxamniquine
Page 119 and 120:
A case study—oxamniquine
Page 121 and 122:
A case study—oxamniquine 109 CH 3
Page 124 and 125:
112 Pharmacodynamics stream. Thirdl
Page 127 and 128:
Drug dose levels 115 can easily neg
Page 129 and 130:
Drug design for pharmacokinetic pro
Page 131 and 132:
Drug design
Page 133 and 134:
Page 135 and 136:
Page 137 and 138:
Page 139:
grown Neurotransmitters as drugs? 1
Page 142 and 143:
130 Quantitative structure-activity
Page 144 and 145:
Page 146 and 147:
Page 148 and 149:
Page 150 and 151:
Page 152 and 153: 140 Quantitative structure-activity
Page 164: 152 Quantitative structure-activity
Page 170 and 171: 158 Antibacterial agents
Page 173 and 174: others. Antibacterial agents which
Page 175 and 176: Antibacterial agents which act agai
Page 177 and 178: Antibacterial agents which
Page 179 and 180: Antibacterial agents which inhibit
Page 183: is tolerated Antibacterial agents w
Page 186 and 187: 174 Antibacterial agents The proble
Page 188 and 189: 176 Antibacterial agents Permeabili
Page 190 and 191: 178 Antibacterial agents H0 2C—C
Page 192 and 193: 180 R
Page 201: Antibacterial agents which inhibit
Page 211 and 212: Antibacterial agents which impair p
Page 213 and 214: Agents which
Page 215 and 216: Drug resistance 203 10.9 Drug resis
Page 217 and 218: 11- The peripheral nervous system
Page 219 and 220: Motor nerves
Page 221 and 222: Actions
Page 223 and 224: The cholinergic system 211 I j V Ac
Page 225: Agonists
Page 229: Agonists at the cholinergic recepto
Page 232 and 233: 220 The peripheral nervous system
Page 235 and 236: Antagonists
Page 237: Structural analogues based Antagoni
Page 240 and 241: 228 The peripheral nervous system I
Page 242 and 243: 230 The peripheral nervous system p
Page 244 and 245: 232 The peripheral nervous system ;
Page 247: Anticholinesterases
Page 250 and 251: 238 The peripheral nervous system r
Page 253 and 254:
Anticholinesterase drugs
Page 255 and 256:
Anticholinesterase drugs
Page 257:
Pralidoxime—an organophosphate an
Page 260 and 261:
248 The opium analgesics Chinese de
Page 263:
Morphine
Page 267:
Development of morphine analogues 2
Page 270 and 271:
258 The opium analgesics R= ——C
Page 272 and 273:
260 The opium analgesics (A) BINDIN
Page 274 and 275:
262 The opium analgesics morphine.
Page 276 and 277:
264 The opium analgesics o N——C
Page 278 and 279:
266 The opium analgesics morphine
Page 281 and 282:
Receptor theory
Page 283 and 284:
Receptor theory
Page 285:
Agonists
Page 289 and 290:
e Receptor mechanisms 277
Page 291 and 292:
membrane to a second membrane-bound
Page 296 and 297:
284 Cimetidine—a rational approac
Page 299:
Searching
Page 302 and 303:
Page 305:
From partial agonist
Page 309:
Development of metiamide 297 the sa
Page 313:
Cimetidine
Page 316 and 317:
304 Cimetidine — a rational appro
Page 318 and 319:
Page 320 and 321:
Page 324 and 325:
Page 326 and 327:
Appendix
Page 329:
a The action of nerves 317
Page 332 and 333:
Appendix
Page 334 and 335:
322 Secondary messengers number
Page 337 and 338:
Secondary messengers
Page 339 and 340:
Haemophilus influenzae Bacteroides
Page 341 and 342:
Glossary
Page 343:
Index acetylcholine 47-8, 207, 209-
Page 346 and 347:
334 Index intestinal infections
Page 348:
336 Index structure-activity analys
show all

An Introduction to Medicinal Chemistry

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?