An Introduction to Medicinal Chemistry

More documents

Recommendations

Info

3 • Protein structure In order <strong>to</strong> understand how drugs interact with proteins, it is necessary <strong>to</strong> understand their structure. Proteins have four levels of structure—primary, secondary, tertiary, and quaternary. 3.1 The primary structure of proteins
Page 1 and 2: An Introduction to Medicinal Chemis
Page 3 and 4: Preface This text is aimed at under
Page 5 and 6: Contents Classification of drugs xi
Page 7 and 8: Contents
Page 9 and 10: Contents xi 11.16.2 Structure
Page 11 and 12: Classification of drugs
Page 13 and 14: 1 • Drugs and the medicinal chemi
Page 15 and 16: Whilst penicillin Drugs and the med
Page 17: Drugs
Page 22 and 23: 10 The why and the wherefore Cytopl
Page 25: Where do drugs work? 13 Amphoterici
Page 30 and 31: 18 Protein structure H R 0 H ^ ^ ^
Page 32 and 33: 20 Protein structure I I I 10 \\
Page 34: 22 Protein structure Fig. 3.10 Hydr
Page 37 and 38: The quaternary structure of protein
Page 40: 28 Drug action at enzymes Energy Tr
Page 44 and 45: 32 Drug action at enzymes Fig.
Page 46 and 47: 34 Drug action
Page 49: The catalytic role of enzymes 37 Fi
Page 54 and 55: 42 Drug action
Page 56: 44 Drug action at enzymes met in th
Page 60 and 61: 48 Drug action at receptors CH 2 +
Page 62: 50 Drug action at receptors Fig. 5.
Page 65 and 66: How does the message get received?
Page 67 and 68: process whereby How does a receptor
Page 70: 58 Drug action at receptors neurotr
Page 73 and 74: A thorough understanding The design
Page 75 and 76: Partial agonists 63 RECEPTOR RECEPT
Page 77 and 78:
Tolerance and dependence 65 5.9 Des
Page 79:
Tolerance and dependence 67 level.
Page 82 and 83:
70 Nucleic acids 6.1.2
Page 84 and 85:
72 Nucleic acids able to coil into
Page 86 and 87:
74 Nucleic acids Fig. 6.9 Proflavin
Page 89 and 90:
Ribonucleic acid
Page 91:
Ribonucleic acid 79 GROWING PROTEIN
Page 95 and 96:
the never-ending quest Structure de
Page 97 and 98:
Structure-activity relationships
Page 99 and 100:
Structure-activity relationships
Page 101 and 102:
Synthetic analogues
Page 103 and 104:
Synthetic analogues
Page 105 and 106:
Synthetic analogues
Page 107 and 108:
Synthetic analogues
Page 109:
Receptor theories 97 NH 2 Me BOND R
Page 114 and 115:
102 Drug development Frequently,
Page 116 and 117:
104 Drug development O IIS—NH —
Page 118 and 119:
Et 2NCH 2CH 2 CH 2NEt 2
Page 120 and 121:
108 Drug development Zero Activity
Page 122:
110 Drug development found
Page 125:
Drug distribution and 'survival' 11
Page 128 and 129:
116 Pharmacodynamics Drugs
Page 130 and 131:
118 Pharmacodynamics Other common m
Page 132 and 133:
120 Pharmacodynamics
Page 134 and 135:
122 Pharmacodynamics Me AZATHIOPRIN
Page 136 and 137:
124 Pharmacodynamics Many peptides
Page 138 and 139:
126 Pharmacodynamics 8.3.9 Self-des
Page 141 and 142:
Graphs and equations 129 What are t
Page 143 and 144:
Physicochemical properties
Page 145 and 146:
Page 147 and 148:
Page 149 and 150:
Page 151 and 152:
Meta Hydroxyl Group Physicochemical
Page 153 and 154:
Quantifying steric properties Hansc
Page 155 and 156:
log [I] The Craig plot 143
Page 157 and 158:
The Topliss scheme 145 and electron
Page 159 and 160:
The Topliss scheme 147 with a negat
Page 161 and 162:
Planning
Page 163 and 164:
Case study
Page 168:
156 Antibacterial agents prontosil
Page 171:
Antibacterial agents which
Page 174 and 175:
162 Antibacterial agents MeO OMe Fi
Page 176 and 177:
164 Antibacterial agents Fig. 10.15
Page 178 and 179:
166 Antibacterial agents drug would
Page 180 and 181:
168 Antibacterial agents -CH2- R—
Page 182 and 183:
170 Antibacterial agents • Ineffe
Page 185 and 186:
Antibacterial agents which inhibit
Page 187 and 188:
Page 189 and 190:
Page 191 and 192:
groups Antibacterial agents which i
Page 193:
Page 196 and 197:
Page 198 and 199:
186 Antibacterial agents = CH 3 C0
Page 200 and 201:
188 Antibacterial agents Second- an
Page 202 and 203:
Page 204 and 205:
192 Antibacterial agents
Page 206 and 207:
194 Antibacterial agents [Normal Me
Page 208 and 209:
196 Antibacterial agents L-Valine M
Page 210 and 211:
198 Antibacterial agents L-LEU —
Page 212 and 213:
200 Antibacterial agents which was
Page 214 and 215:
202 Antibacterial agents o ,CO2H HN
Page 216 and 217:
204 Antibacterial agents transferre
Page 218 and 219:
206 The peripheral nervous system y
Page 220 and 221:
208 The peripheral nervous system S
Page 222 and 223:
210 The peripheral nervous system N
Page 224 and 225:
212 The peripheral nervous system 1
Page 227:
Agonists at the cholinergic recepto
Page 231 and 232:
Water Design of acetylcholine analo
Page 233:
Design
Page 236 and 237:
224 The peripheral nervous system H
Page 239 and 240:
A large variety Antagonists of the
Page 241 and 242:
Antagonists
Page 243 and 244:
Antagonists
Page 245:
drug design Other cholinergic antag
Page 249 and 250:
Anticholinesterases
Page 251:
Anticholinesterase drugs 239 - Pyrr
Page 254 and 255:
242 The peripheral nervous system M
Page 256 and 257:
244 The peripheral nervous system F
Page 259 and 260:
N—CH 3 MeO. R'O* R
Page 261:
Morphine 249 12.2 Morphine 12.2.1 S
Page 265:
Morphine 253 To conclude, the 6-hyd
Page 269 and 270:
Development
Page 271 and 272:
Development of morphine analogues 2
Page 273 and 274:
Development
Page 275 and 276:
Development
Page 277 and 278:
Page 279:
Page 282 and 283:
270 The opium analgesics analgesic
Page 284 and 285:
272 The opium analgesics acts as a
Page 287:
Enkephalins
Page 290 and 291:
278 The opium analgesics narcotic a
Page 292:
280 The opium analgesics O II N —
Page 297:
Searching
Page 301 and 302:
Searching for a lead—AT-guanylhis
Page 303:
Developing the lead—a chelation b
Page 307:
Development of metiamide 295 meanin
Page 311:
Development
Page 315 and 316:
Further studies—cimetidine analog
Page 317 and 318:
Page 319 and 320:
Page 321:
Famotidine and nizatidine 309 • R
Page 325 and 326:
Appendix
Page 327:
(vesicles) containing The action of
Page 331 and 332:
The action of nerves 319 x Briv "-
Page 333 and 334:
Secondary messengers
Page 335:
Secondary messengers 323 the proces
Page 338 and 339:
Appendix 4 • Bacteria and bacteri
Page 340 and 341:
Glossary ADDICTION Addiction can be
Page 342 and 343:
Further reading Albert,
Page 345 and 346:
drug addiction 1, 3, 5, 127, 248, 2
Page 347 and 348:
penillic acids 172 pentagastrin Ind
show all

An Introduction to Medicinal Chemistry

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?