An Introduction to Medicinal Chemistry

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116 Pharmacodynamics Drugs
Drug design for pharmacokinetic problems 117 NH—C—CH 2CH2NEt 2 LIDOCAINE A further example of these tactics is provided in the penicillin field with methicillin (Chapter 10). 8.3.3 Metabolic blockers Some drugs
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An Introduction to Medicinal Chemis
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Preface This text is aimed at under
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Contents Classification of drugs xi
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Contents
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Contents xi 11.16.2 Structure
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Classification of drugs
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1 • Drugs and the medicinal chemi
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Whilst penicillin Drugs and the med
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Drugs
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10 The why and the wherefore Cytopl
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Where do drugs work? 13 Amphoterici
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16 Protein structure [ H O
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The tertiary structure of proteins
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The tertiary structure of proteins
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24 Protein structure H-Bond Peptide
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26 Protein structure again that ter
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Substrate binding
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Substrate binding at an active site
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Substrate binding
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R The catalytic role of enzymes Thy
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I NH 2 CHO (OH Condensation R< The
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Nerve Neurotransmitters
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Receptors
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52 Drug action at receptors Induced
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54 Drug action at receptors MESSENG
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56 Drug action at receptors RECEPTO
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60 Drug action at receptors left-ha
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62 Drug action
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64 Drug action
Page 78 and 79: 66 Drug action at receptors D Neuro
Page 81 and 82: Structure of DNA 69 NH 2 NHo NHo Ad
Page 83 and 84: Structure
Page 85 and 86: Drugs acting
Page 87: Drugs acting on DNA 75 CH3—N: MEC
Page 90 and 91: 78 Nucleic acids end AMINO «A/* Ba
Page 93: Summary 81
Page 96 and 97: 84 Drug development
Page 98 and 99: 86 Drug development | | Potential I
Page 100 and 101: 88 Drug development bonding or not,
Page 102 and 103: 90 Drug development 7.5.1 Variation
Page 104 and 105: 92 Drug development covered
Page 106 and 107: 94 Drug development avoiding patent
Page 108 and 109: 96 Drug development ,OH OH GLIPINE
Page 111: Receptor theories
Page 115 and 116: Lead compounds
Page 117 and 118: A case study—oxamniquine
Page 119 and 120: A case study—oxamniquine
Page 121 and 122: A case study—oxamniquine 109 CH 3
Page 124 and 125: 112 Pharmacodynamics stream. Thirdl
Page 127: Drug dose levels 115 can easily neg
Page 131 and 132: Drug design
Page 133 and 134: Drug design for pharmacokinetic pro
Page 139: grown Neurotransmitters as drugs? 1
Page 142 and 143: 130 Quantitative structure-activity
Page 164: 152 Quantitative structure-activity
Page 170 and 171: 158 Antibacterial agents
Page 173 and 174: others. Antibacterial agents which
Page 175 and 176: Antibacterial agents which act agai
Page 177 and 178: Antibacterial agents which
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Antibacterial agents which inhibit
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is tolerated Antibacterial agents w
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174 Antibacterial agents The proble
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176 Antibacterial agents Permeabili
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178 Antibacterial agents H0 2C—C
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180 R
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Antibacterial agents which
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Antibacterial agents which
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Antibacterial agents which impair p
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Agents which
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Drug resistance 203 10.9 Drug resis
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11- The peripheral nervous system
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Motor nerves
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Actions
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The cholinergic system 211 I j V Ac
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Agonists
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Agonists at the cholinergic recepto
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220 The peripheral nervous system
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Antagonists
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Structural analogues based Antagoni
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228 The peripheral nervous system I
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230 The peripheral nervous system p
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232 The peripheral nervous system ;
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Anticholinesterases
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238 The peripheral nervous system r
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Anticholinesterase drugs
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Anticholinesterase drugs
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Pralidoxime—an organophosphate an
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248 The opium analgesics Chinese de
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Morphine
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Development of morphine analogues 2
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258 The opium analgesics R= ——C
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260 The opium analgesics (A) BINDIN
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262 The opium analgesics morphine.
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264 The opium analgesics o N——C
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266 The opium analgesics morphine
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Receptor theory
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Receptor theory
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Agonists
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e Receptor mechanisms 277
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membrane to a second membrane-bound
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284 Cimetidine—a rational approac
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Searching
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From partial agonist
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Development of metiamide 297 the sa
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Cimetidine
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304 Cimetidine — a rational appro
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Appendix
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a The action of nerves 317
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Appendix
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322 Secondary messengers number
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Secondary messengers
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Haemophilus influenzae Bacteroides
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Glossary
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Index acetylcholine 47-8, 207, 209-
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334 Index intestinal infections
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336 Index structure-activity analys
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An Introduction to Medicinal Chemistry

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