Management of Snakebite and Research Management of Snakebite ...
Management of Snakebite and Research Management of Snakebite ...
Management of Snakebite and Research Management of Snakebite ...
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Table 7. Potent biological properties <strong>of</strong> venoms <strong>of</strong> young Russell’s vipers<br />
Property Lower Myanmar Upper Myanmar<br />
LD 50 µg/mouse Nyaungdon 2.87 Thaze 6.3<br />
MHD µg/rat Danuphyu/Htantabin 30.9 Taungdwingyi 41.7<br />
MND µg/rat Kungyankone 20.4 Thaze 39.8<br />
MDD µg/mouse Kungyankone 1.8 Taungdwingy 13.0<br />
MCD µg/ml Minhla 0.072 Kyauksae 0.04<br />
MCPID µg/ml Thayarwaddy 0.0007 Kyauksae 0.066<br />
Table 8. Comparison <strong>of</strong> the potent biological properties <strong>of</strong> venoms<br />
<strong>of</strong> young <strong>and</strong> adult Russell’s vipers<br />
Property Young viper Adult viper<br />
LD 50 µg/mouse Nyaungdon 2.87 Daedaye 2.86<br />
MHD µg/rat Danuphyu 30.9 Aunglan 23.7<br />
MND µg/rat Kungyankone 20.4 Pantanaw 20.42<br />
MDD µg/mouse Kungyankone 1.8 Taungdwingyi 1.0<br />
MCD mg/ml Kyauksae 0.04 Nyaungdon 0.033<br />
MCPID µg/ml Tharyarwaddy 0.0007 Tharawaddy 0.0007<br />
It could be summarised that venoms <strong>of</strong> young vipers from lower Myanmar (Nyaungdon,<br />
Danuphyu, Htantabin, Kungyankone, <strong>and</strong> Tharawaddy) possess biological properties except<br />
coagulant (Kyauksae).<br />
Venom variation among adult Russell’s vipers<br />
Venom possessing potent biological properties from each division (Table 9); lower <strong>and</strong><br />
upper Myanmar (Table 10) <strong>and</strong> five divisions (Table 8) are shown in respective tables.<br />
Property<br />
LD50 µg/mouse<br />
MHD<br />
µg/rat<br />
MND<br />
µg/rat<br />
MDD<br />
µg/mouse<br />
MCD<br />
µg/ml<br />
Ayerawaddy<br />
n=5<br />
Daedaye<br />
2.86<br />
Pyapone<br />
23.99<br />
Lower Myanmar Upper Myanmar<br />
Yangon<br />
n=5<br />
Htantabin<br />
3.26<br />
Kungyankone<br />
26.3<br />
Pantanaw 20.42 Htantabin<br />
21.6<br />
Daedaye<br />
1.78<br />
Nyaungdon<br />
0.033<br />
Htantabin<br />
1.8<br />
Kungyankone<br />
0.31<br />
Bago<br />
n=4<br />
Daike-Oo<br />
3.24<br />
Letpadan<br />
37.15<br />
Wall<br />
31.26<br />
M<strong>and</strong>alay<br />
n=3<br />
Thaze<br />
3.75<br />
Kyauksae<br />
54.3<br />
Tharawaddy 2.4 Thaze<br />
2.0<br />
Wall<br />
0.141<br />
MCPID µg/ml Daedaye 0.009 Htantabin 0.008 Tharawaddy<br />
0.0007<br />
Geographical Variation <strong>of</strong> Biological Properties <strong>of</strong> Russell’s Viper Venom<br />
Table 9. Biological properties <strong>of</strong> venoms <strong>of</strong> adult Russell’s vipers<br />
Magwe<br />
Taungdwingyi<br />
3.97<br />
Aunglan<br />
23.7<br />
Thaze 39.31 Aunglan<br />
25.1<br />
Taungdwingyi 1.0<br />
Thaze 0.630 Pakokku<br />
0.159<br />
Thaze 0.0707 Taungdwingyi<br />
0.083<br />
69
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