ayout 1 - EMBL Grenoble

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Contents4 Foreword by EMBL’s Director General5 EMBL Heidelberg, Germany7 Cell Biology and Biophysics Unit22 Developmental Biology Unit31 Gene Expression Unit41 Structural and Computational Biology Unit52 Directors’ Research55 Core Facilities63 EMBL-EBI, Hinxton, UKEuropean Bioinformatics Institute87 EMBL Grenoble, FranceStructural Biology97 EMBL Hamburg, GermanyStructural Biology108 EMBL Monterotondo, ItalyMouse Biology118 Index of group leaders
EMBL Research at a Glance 2009Foreword by EMBL’s Director GeneralEMBL – Europe’s flagship laboratory for basicresearch in molecular biologyThe vision of the nations which founded the European Molecular Biology Laboratory was to create acentre of excellence where Europe’s best brains would come together to conduct basic research inmolecular biology. During the past three decades, EMBL has grown and developed substantially,and its member states now number twenty-one, including the first associate member state, Australia.Over the years, EMBL has become the flagship of European molecular biology and is ranked as oneof the top research institutes worldwide.EMBL’s missions are to perform cutting-edge research in molecular biology, to offer services to Europeanscientists, to provide advanced training to researchers at all levels, to develop new technologiesand instrumentation and to actively engage in technology transfer for the benefit of scientistsand society.In research, the five EMBL sites (a central laboratory in Heidelberg, with outstations in Grenoble,Hamburg, Hinxton and Monterotondo) put strong emphasis on interdisciplinarity and collaboration,and when the researchers leave to assume key positions in the member states, they export theirunique experience of working in a very energetic and international environment. Freedom, flexibilityand a regular turnover of staff allows EMBL to pursue the most exciting themes in molecular biologyas they arise. Our long-standing tradition of organising excellent courses, conferences andworkshops and an extensive outreach programme ensure that know-how spreads further and informsthe public about the impact modern biology has on our lives.In Research at a Glance you will find a concise overview of the work of our research groups and corefacilities. Science at EMBL covers themes ranging from studies of single molecules to an understandingof how they work together in complex systems to organise cells and organisms. Our researchis loosely structured under thematic units, giving scientists the intellectual freedom to pursuethe topics that most interest them.But what really distinguishes EMBL is the large number of inter-unit collaborations, bringing peoplewith common interests but distinct expertise together to tackle ambitious projects. Cross-unit networkingand training further support scientists working on interdisciplinary projects. Increasingly,our young scientists come with physics, chemistry, mathematics and computer science backgrounds,bringing in expertise that helps us to move into the growing field of systems biology.EMBL combines a critical mass of expertise and resources with organisational flexibility, enabling usto keep pace with today’s biology. The impact of the laboratory’s scientific work, the quality of itsservices and its continued attractiveness to world-leading young scientists are testimony to EMBL’ssuccess, and show that we are well-equipped for the future.Iain MattajEMBL Director General
Page 6: EMBL Heidelberg, GermanyA city of a
Page 9: EMBL Research at a Glance 2009Jan E
Page 14 and 15: Cell Biology and Biophysics UnitChr
Page 16 and 17: Cell Biology and Biophysics UnitDyn
Page 18 and 19: Cell Biology and Biophysics UnitCel
Page 20 and 21: Cell Biology and Biophysics UnitChe
Page 22 and 23: Cell Biology and Biophysics UnitPhy
Page 24 and 25: Developmental Biology UnitCell pola
Page 26 and 27: Developmental Biology UnitTiming of
Page 28 and 29: Developmental Biology UnitDevelopme
Page 30 and 31: Developmental Biology UnitGene regu
Page 32 and 33: Gene Expression UnitThe genome enco
Page 34 and 35: Gene Expression UnitFunctional geno
Page 36 and 37: Gene Expression UnitComputational G
Page 38 and 39: Gene Expression UnitStudying the or
Page 40 and 41: Gene Expression UnitChromatin plast
Page 42 and 43: Structural and Computational Biolog
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Structural and Computational Biolog
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Directors’ ResearchThe RanGTPase
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Core FacilitiesThe Core Facilities
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Core FacilitiesChemical Biology Cor
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Core FacilitiesFlow Cytometry Core
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Core FacilitiesProtein Expression a
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EMBL-EBI, Hinxton, UKThe European B
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EMBL-EBIDifferentiation and develop
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EMBL-EBIEvolutionary tools for sequ
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EMBL-EBIGenome-scale analysis of re
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EMBL-EBIPANDA proteins and the Apwe
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EMBL-EBIThe Microarray Informatics
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EMBL-EBIThe GO Editorial OfficePrev
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EMBL-EBIThe Proteomics Services Tea
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EMBL-EBIEnsembl GenomesPrevious and
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EMBL-EBIChemogenomics and drug disc
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EMBL-EBIThe Microarray Software Dev
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EMBL-EBILiterature resource develop
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EMBL Grenoble, FranceThe EMBL outst
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EMBL GrenobleStructural biology of
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EMBL GrenobleHigh-throughput protei
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EMBL GrenobleSynchrotron Crystallog
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EMBL GrenobleRegulation of gene exp
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EMBL Hamburg, GermanyEMBL Hamburg
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EMBL HamburgInstrumentation for syn
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EMBL HamburgMacromolecular crystall
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EMBL HamburgDisease-related protein
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EMBL HamburgSAXS studies of biologi
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EMBL HamburgX-ray crystallography o
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EMBL MonterotondoRegenerative mecha
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EMBL MonterotondoMolecular physiolo
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EMBL MonterotondoTranscription fact
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Notes115
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Notes117
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Ladurner, Andreas 39 LLamzin, Victo
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