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Mcleod 2001 {published data only}∗ Mcleod RS, Geerts WH, Sniderman K, Greenwood C, GregoireRC Taylor BM, Silverman RE, Atk<strong>in</strong>son KG, Burnste<strong>in</strong> M, MarshallJC, Burul, CJ, Anderson DR, Ross T, Wilson SR, Barton P <strong>and</strong>other <strong>in</strong>vetigators of the Canadian Colorectal Surgery DVT ProphylaxisTrial. Subcutaneous Hepar<strong>in</strong> Versus Low-Molecular- WeightHepar<strong>in</strong> as Thromboprophylaxis <strong>in</strong> patients undergoung ColorectalSurgery. Results of the Canadian Colorectal DVT Prophylaxis Trial:A R<strong>and</strong>omized, Double-Bl<strong>in</strong>dTrial. Annals of Surgery 2001;233(3):438–444.Negus 1980 {published data only}∗ Negus D, Friedgood A. Ultra-low dose <strong>in</strong>travenous hepar<strong>in</strong> <strong>in</strong> theprevention of postoperative deep ve<strong>in</strong> thrombosis. Lancet 1980;1:891–894.Nicolaides 1983 {published data only}Nicolaides AN, Miles C, Hoare M, Jury P, Helmis E, Venniker R. Intermittentsequential pneumatic compression of the legs <strong>and</strong> thromboembolism-deterrentstock<strong>in</strong>gs <strong>in</strong> the prevention of postoperativedeep venous thrombosis. Surgery 1983;94(1):21–5. 83224179.Onarheim 1986 {published <strong>and</strong> unpublished data}Onarheim H, Lund T, Heimdal A, Arnesjo B. A low molecular weighthepar<strong>in</strong> (KABI 2165) <strong>for</strong> prophylaxis of postoperative deep venousthrombosis. Acta Chir Sc<strong>and</strong> 1986;152:593–596. 87123126.Rem 1975 {published data only}Rem J, Duckert F, Fridrich R, Gruber UF. Subcutaneous small hepar<strong>in</strong>doses <strong>for</strong> the prevention of thrombosis <strong>in</strong> general surgery <strong>and</strong>urology [Subcutane kle<strong>in</strong>e hepar<strong>in</strong>dosen zur thromboseprophylaxe<strong>in</strong> der allgeme<strong>in</strong>en chirurgie und urologie]. Schweiz Med Wochenschr1975;105(26):827–35. 76129481.Torngren 1978 {published data only}∗ Torngren S, Forsberg K. Concentrated or diluted hepar<strong>in</strong> prophylaxisof postoperative deep venous thrombosis. Acta-Chir-Sc<strong>and</strong> 1978;144:283–285. CN-00202745 - CCTR. MEDLINE79100149 EMBASE 79071859.Valle 1988 {published data only}∗ Valle I, Sola G, Origone A. Controlled cl<strong>in</strong>ical study of the efficacyof a new low molecular weight hepar<strong>in</strong> adm<strong>in</strong>istered subcutaneouslyto prevent post-operative deep venous thrombosis. Curr-Med-Res-Op<strong>in</strong> 1988;11:80–86. CN-00068595 - CCTR. MEDLINE89120181.Wille-Jørgensen 1986 {published <strong>and</strong> unpublished data}∗ Wille-Jorgensen P. Lavdosis-hepar<strong>in</strong> komb<strong>in</strong>eret med enten dihyroergotam<strong>in</strong>eller graderede støttestrømper [Low-dosage hepar<strong>in</strong>comb<strong>in</strong>ed with either dihydroergotam<strong>in</strong>e or graduated supportivestock<strong>in</strong>gs. Comb<strong>in</strong>ed prevention of thrombosis <strong>in</strong> colonic surgery]].Ugeskr Laeger 1986;148:501–503. 86181188.Wille-Jørgensen 1991 {published data only}∗ Wille-Jorgensen P, Hauch O, Dimo B, Christensen SW, JensenR, Hansen B. Prophylaxis of deep venous thrombosis after acuteabdom<strong>in</strong>al operation. Surg Gynecol Obstet 1991;172:44–48.References to studies excluded from this reviewBounameaux 1993Bounameaux H, Huber O, Khabiri E, Schneider PA, Didier D,Rohner A. Unexpectedly high rate of phlebographic deep venousthrombosis follow<strong>in</strong>g elective general abdom<strong>in</strong>al surgery among patientsgiven prophylaxis with low-molecular-weight hepar<strong>in</strong>. ArchSurg 1993;128:326–8.Browse 1974∗ Browse NL, Jackson BT, Mayo ME, Negus. The value of <strong>mechanical</strong><strong>methods</strong> of prevent<strong>in</strong>g postoperative calf ve<strong>in</strong> thrombosis. Br.J.Surg1974;61(3):219–23.Comerota 1986 AComerota AJ. Review of the Multicenter Trial Committee report: aprospective, r<strong>and</strong>omized study on the prophylaxis of postoperativedeep venous thrombosis. Pharmacotherapy 1986;6:18S–22S.Ellis 1982Ellis H, Scurr JH. Prophylaxis of venous thrombosis. Phlebologie1982;35:135–42.Gallus 1993Gallus A, Cade J, Ockel<strong>for</strong>d P, Hepburn S, Maas M, Magnani H,Bucknall T, Stevens J, Porteous F. Orgaran (Org 10172) or hepar<strong>in</strong><strong>for</strong> prevent<strong>in</strong>g venous thrombosis after elective surgery <strong>for</strong> malignantdisease? A double-bl<strong>in</strong>d, r<strong>and</strong>omised, multicentre comparison. ANZ-Organon Investigators’ Group. Thromb Haemost 1993;70:562–7.Kakkar 1993Kakkar VV. Multicentre r<strong>and</strong>omized double-bl<strong>in</strong>d trial of low molecularweight hepar<strong>in</strong> <strong>and</strong> st<strong>and</strong>ard hepar<strong>in</strong> <strong>for</strong> prevention of postoperativevenous thromboembolism <strong>in</strong> major abdom<strong>in</strong>al surgery. BritishJournal Of Surgery 1993;80:S112. CN-00128856.Mcleod 1995Mcleod RS, Geerts WH, Sniderman K, Greenwood C, Gregoire R,Taylor B, et al. Thromboprophylaxis <strong>in</strong> colorectal surgery - A r<strong>and</strong>omizedtrial compar<strong>in</strong>g low dose hepar<strong>in</strong> <strong>and</strong> enoxapar<strong>in</strong>. Thrombosis<strong>and</strong> Haemostasis 1995;73(6):973, no 309.No author 1984No authors listed. Prophylactic efficacy of low-dose dihydroergotam<strong>in</strong>e<strong>and</strong> hepar<strong>in</strong> <strong>in</strong> postoperative deep venous thrombosis follow<strong>in</strong>g<strong>in</strong>tra-abdom<strong>in</strong>al operations. J Vasc Surg 1984;1:608–16.85058460.Rasmussen 1988Rasmussen A, Hansen PT, L<strong>in</strong>dholt J, Poulsen, T, Toftdahl DB,Gram J, Toftgaard C, Jespersen J. Venous thrombosis after abdom<strong>in</strong>alsurgery. A comparison between subcutaneous hepar<strong>in</strong> <strong>and</strong> antithromboticstock<strong>in</strong>gs, or both. J-Med 1988;19(3 <strong>and</strong> 4):193–201.CN-00068984 - CCTR. MEDLINE 89035909.Str<strong>and</strong> 1975Str<strong>and</strong> L, Bank-Mikkelsen OK, L<strong>in</strong>dewald H. Small hepar<strong>in</strong> dosesas prophylaxis aga<strong>in</strong>st deep-ve<strong>in</strong> thrombosis <strong>in</strong> major surgery. Acta-Chir-Sc<strong>and</strong> 1975;141:624–627. CN-00195984 - CCTR. MED-LINE 76108173.Torngren 1982Torngren S, Rieger A. Prophylaxis of deep venous thrombosis <strong>in</strong>colorectal surgery. Dis Colon Rectum 1982;25(6):563–6.Törngren 1980Torngren S. Low dose hepar<strong>in</strong> <strong>and</strong> compression stock<strong>in</strong>gs <strong>in</strong> theprevention of postoperative deep venous thrombosis. Br J Surg 1980;67(7):482–4. 81022208.<strong>Hepar<strong>in</strong>s</strong> <strong>and</strong> <strong>mechanical</strong> <strong>methods</strong> <strong>for</strong> <strong>thromboprophylaxis</strong> <strong>in</strong> colorectal surgery (Review)Copyright © 2006 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd7

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