Heparins and mechanical methods for thromboprophylaxis in ...

Characteristics of included studies (Continued )ParticipantsInterventionsOutcomesNotesAllocation concealmentElective surgical abdominal patients. 52 randomized patients. 1 patient excluded. Leaving 51 in per protocolanalysis. Subgroup of 46 colorectal patients were distributed with respectively 48% and 52% in the twotreatment arms.LMWH: 5000 anti-x-activated (medium dose) units preoperatively and x1 plus placebo x1 postoperativelyfor six days.LDH: 5000 U unfractionated heparin preoperatively and eigth o´ cloc p.m. at the day of surgery and x2postoperatively for six days.Thromboembolic events: DVTBleeding events: Not specified in colorectal patients.Diagnosis: Radiofibrinogen uptake test every day or every second day for at least 7 days.1 missing patient.Balanced distribution of colorectal patients.BStudy Rem 1975MethodsParticipantsInterventionsOutcomesNotesAllocation concealmentRCT. Sealed envelopes. Surgeon blinded. Not patient nor outcome-assessor blinded. (Control group = notreatment).No primary stratification of colorectal patients.Elective surgical abdominal- and urological patients. 212 randomized patients. 22 excluded patients in LDHarm and 12 excluded patients in no treatment arm. Leaving 178 patients in per protocol analysis. Subgroupof 31 colorectal patients were distributed with respectively 61% and 39% in the two treatment arms.LDH: 5000 units of unfractionated heparin preoperatively and x3 postoperatively for at least 7 days.Control: No treatment.Thromboembolic events: DVT.Bleeding: Not specified in colorectal patientsDiagnosis: Rradiofibrinogen uptake test, daily34 patients missing. No intention to treat analysis.Unbalanced distribution of colorectal patients.AStudy Torngren 1978MethodsParticipantsInterventionsOutcomesNotesAllocation concealmentRCT. Coded vials. Patient-, surgeon- and outcome-assessor blinded. No primary stratification of colorectalpatients.Elective surgical abdominal patients. 175 randomized patients. From the three arm were respectively excluded3, 4 and 1 patient. Leaving 167 patients in per protocol analysis. Subgroup of 107 colorectal patients weredistributed with respectively 38%, 30% and 32 % in the three arms.LDH: 5000 u unfrationated heparin preoperatively and x2 postoperatively for 6 to 8 days.HDH: 25000 u unfrationated heparin preoperatively and x2 postoperatively for 6 to 8 days.Control group: PlaceboThromboembolic events: DVTBleeding events: Not specified in colorectal patients.Diagnosis: Radiofrbinogen uptake test performed at a mean of 10.5 days.8 missing patients. No intention to treat analysis.Balanced distribution of colorectal patients.AHeparins and mechanical methods for thromboprophylaxis in colorectal surgery (Review)Copyright © 2006 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd16