Lecture Antimicrobial peptides .pdf
Lecture Antimicrobial peptides .pdf
Lecture Antimicrobial peptides .pdf
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signal20-30 aaconserved prepro regionCATHELICIDINSpropiece100-120 aapeptide19-94 aavariable active domainFamily found only in mammals, ca. 40 membersN-terminal highly conserved, identifies cathelicidinsExpressed in bone marrow, stored in peroxidase-negativeneutrophil granules, then exocytosed from activated cellsMost are without antibacterial activity until C-terminalproteolytically removed