Lecture Antimicrobial peptides .pdf

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Tried to develop therapeutic usefor magaininsCurrently researching human<strong>peptides</strong>Michael Zasloff: 1986Observed antibacterial resistance inXenopus laevis• Identified 1 st amphibian peptide –magainin• Magainins stored in neuroepithelial cells• Form bacteria-resistant ‘mesh’• Amphipathic α helixXenopus laevis
Page 1: ANTIMICROBIAL PEPTIDES
Page 7 and 8: ANTIMICROBIAL DATABASES ON THE WEBT
Page 9 and 10: Data from theWellcome Trust, U.K.
Page 11 and 12: A GLOBAL PROBLEM:
Page 13 and 14: Where are AMPs found ?ProcaryotesMi
Page 15 and 16: α - Defensinssignal propiece activ
Page 18 and 19: signal20-30 aaconserved prepro regi
Page 20 and 21: Antibacterial fragments of larger p
Page 22 and 23: Clustering of cationic and hydropho
Page 24 and 25: α−helicalpeptideThe Shai-Matsuza
Page 26 and 27: RegulationAMPs may be expressed con
Page 28 and 29: OTHER BIOLOGICAL FUNCTIONSOF ANTIMI
Page 30 and 31: AMPS IN OTHER ANIMALSMOLLUSCSDefens
Page 32 and 33: AMPs in crustaceansPenaeidins(shrim
Page 34 and 35: CarcininSDS-PAGERelf et al, 199911.
Page 36 and 37: Crustins(shrimps)Bartlett et al, 20
Page 38: References:Hans Boman (1981) Struct

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