Lecture Antimicrobial peptides .pdf
Lecture Antimicrobial peptides .pdf
Lecture Antimicrobial peptides .pdf
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SYNERGISM• Mor et al., 1994 demonstrated potent synergy between the 5dermaseptins (DSs1 to s5) from Phyllomedusa sauvagii (frog)• Occurs despite similar structure and proposed mode of action?• Proposed that significance of 5 closely related <strong>peptides</strong> is toprovide potent, broad-spectrum protection from invading microorganisms• Also known that antimicrobial synergy occurs betweendifferent <strong>peptides</strong> from Xenopus laevis eg., magainins• Multi-site mode of action means lower concentrations ofindividual active <strong>peptides</strong> are required
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