Approach to Thrombocytopenia

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Workup• The remainder of the workup is guided by clinicalpresentation• A positive direct Coombs test suggests an immunemediatedprocess• Consider ANA and auto-antibodies in patients withpersistent thrombocytopenia• Fibrin degradation products are present in DIC; uremia ispresent in HUS
Workup• A bone marrow exam is not usually necessary, but isindicated if there is pancytopenia, peripheral blasts,constitutional symptoms, or bone pain• For infants with multiple congenital anomalies, considerhead U/S, MRI, abdominal U/S, and echo• Consider genetic testing for patients with poor growth ordysmorphic features• HIV and Hepatitis C can be associated with chronicthrombocytopenia
Page 1 and 2: The McMasterat nightPediatricCurric
Page 3 and 4: Background• Platelets are irregul
Page 5 and 6: The Answer• The normal platelet c
Page 7 and 8: The Case
Page 9 and 10: History• Past and current bleedin
Page 11 and 12: Physical ExamWhat would you look fo
Page 13 and 14: WorkupWhat would you order?
Page 15: Workup• Peripheral Blood Smear•
Page 19 and 20: Differential DiagnosisDecreased Pro
Page 21 and 22: ITP• Treatment is considered if p
Page 23 and 24: Neonatal AlloimmuneThrombocytopenia
Page 25 and 26: Kasabach-Merritt• Infant thromboc
Page 27 and 28: The Answer• Wiskott-Aldrich syndr
Page 29 and 30: The Answer• Persistent ITP can be
Page 31: Summary• There is no absolute thr

Approach to Thrombocytopenia

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