Approach to Thrombocytopenia

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Neonatal AutoimmuneThrombocytopenia (NAT)• Isolated destruction of platelets by maternal antibodiesdirected against maternal antigens, as in the case ofantepartum maternal ITP or SLE• Clinical presentation similar to NAIT, but higher plateletlevels and lower risk of serious hemorrhage• Treated with steroids or IVIG; maternal-matched plateletinfusion is ineffective
Kasabach-Merritt• Infant thrombocytopenia caused by a large or rapidlygrowinghemangioma that traps platelets• Aside from significant bleeding, complications include DICfrom consumption of coagulation factors and high-outcardiac failure• If surgery is not an option, treatment includes steroids,vincristine, and embolization
Page 1 and 2: The McMasterat nightPediatricCurric
Page 3 and 4: Background• Platelets are irregul
Page 5 and 6: The Answer• The normal platelet c
Page 7 and 8: The Case
Page 9 and 10: History• Past and current bleedin
Page 11 and 12: Physical ExamWhat would you look fo
Page 13 and 14: WorkupWhat would you order?
Page 15 and 16: Workup• Peripheral Blood Smear•
Page 17 and 18: Workup• A bone marrow exam is not
Page 19 and 20: Differential DiagnosisDecreased Pro
Page 21 and 22: ITP• Treatment is considered if p
Page 23: Neonatal AlloimmuneThrombocytopenia
Page 27 and 28: The Answer• Wiskott-Aldrich syndr
Page 29 and 30: The Answer• Persistent ITP can be
Page 31: Summary• There is no absolute thr

Approach to Thrombocytopenia

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