Approach to Thrombocytopenia

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Objectives• Understand the evaluation of an infant or child presentingwith thrombocytopenia• Recognize signs and symptoms that suggest lifethreateningdiagnoses• Triage patients for appropriate treatment based onunderlying etiology and risk of bleeding
Background• Platelets are irregular cell fragments derived from bonemarrow megakaryocytes• Platelets are responsible for primary hemostasis throughthe formation of platelet plugs• The coagulation cascade participates in secondaryhemostasis by creating a firm, stable fibrin clot• Thrombocytopenia is defined as a platelet count less than150 x 10 9 /L
Page 1: The McMasterat nightPediatricCurric
Page 5 and 6: The Answer• The normal platelet c
Page 7 and 8: The Case
Page 9 and 10: History• Past and current bleedin
Page 11 and 12: Physical ExamWhat would you look fo
Page 13 and 14: WorkupWhat would you order?
Page 15 and 16: Workup• Peripheral Blood Smear•
Page 17 and 18: Workup• A bone marrow exam is not
Page 19 and 20: Differential DiagnosisDecreased Pro
Page 21 and 22: ITP• Treatment is considered if p
Page 23 and 24: Neonatal AlloimmuneThrombocytopenia
Page 25 and 26: Kasabach-Merritt• Infant thromboc
Page 27 and 28: The Answer• Wiskott-Aldrich syndr
Page 29 and 30: The Answer• Persistent ITP can be
Page 31: Summary• There is no absolute thr

Approach to Thrombocytopenia

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