Approach to Thrombocytopenia

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Differential DiagnosisIncreased DestructionImmune-mediatedImmune Thrombocytopenia PurpuraNeonatal Alloimmune ThrombocytopeniaNeonatal Autoimmune ThrombocytopeniaSystemic Lupus ErythematosusDrug-induced thrombocytopeniaEvans SyndromeMechanical DestructionDialysisECMOPlatelet ConsumptionHemolytic-Uremic SyndromeThrombotic Thrombocytopenic PurpuraDisseminated Intravascular CoagulationKasabach-Merritt SyndromeSplenic sequestrationMalariaSickle-cell diseasePortal hypertensionVon-Willebrand Subtypes
Differential DiagnosisDecreased ProductionInfectionEBVHIVHCVParvovirusVaricellaCMV (congenital or acquired)Rubella (congenital)Nutritional DeficienciesFolateVitamin B12Bone Marrow Failure/InfiltrationLeukemiaMyelodysplastic syndromesOther malignanciesAcquired aplastic anemiaGenetic CausesFanconi anemiaWiscott-Aldrich SyndromeDyskeratosis congenitaThrombocytopenia Absent RadiiCongenital amegakaryoticthrombocytopenia
Page 1 and 2: The McMasterat nightPediatricCurric
Page 3 and 4: Background• Platelets are irregul
Page 5 and 6: The Answer• The normal platelet c
Page 7 and 8: The Case
Page 9 and 10: History• Past and current bleedin
Page 11 and 12: Physical ExamWhat would you look fo
Page 13 and 14: WorkupWhat would you order?
Page 15 and 16: Workup• Peripheral Blood Smear•
Page 17: Workup• A bone marrow exam is not
Page 21 and 22: ITP• Treatment is considered if p
Page 23 and 24: Neonatal AlloimmuneThrombocytopenia
Page 25 and 26: Kasabach-Merritt• Infant thromboc
Page 27 and 28: The Answer• Wiskott-Aldrich syndr
Page 29 and 30: The Answer• Persistent ITP can be
Page 31: Summary• There is no absolute thr

Approach to Thrombocytopenia

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