Approach to Thrombocytopenia

The Answer• Wiskott-Aldrich syndrome is a rare X-linked recessiveimmunodeficiency disorder characterized by the triad ofrecurrent bacterial infections, eczema, andthrombocytopenia with variable severity• WAS is caused by a mutation in the WASprotein which regulates platelet productionand antibody function• Treatment ranges from conservative, tosymptomatic (platelet tranfusion, topicalsteroids, antibiotics), to hematopoietic stemcell transplant