Q - CRRT Online

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Current Issues in Renal ReplacementTherapy for AKI• What are the indications?• When should therapy be initiated? (and when should it be stopped?)• What are the critical elements of the RRT prescription?• Type of technique (convection vs diffusion)• Vascular access and equipment selection• Membrane and anticoagulation• Frequency of the technique (Intermittent vs continuous)• Dose of RRT (mL/kg/hr vs Kt/V vs ?)• Who will manage the practical aspects of delivering RRT?
Dose of Treatment• The concept of dose has not been clearly defined• What does it mean ?– During <strong>CRRT</strong>– During IHD– During SLED• Dose of what?– Marker molecules– Utrafiltration– Biomarkers of blood purification• Adequacy and inadequacy of treatment
Page 1: CRRT Dose WorkshopWilliam R. Clark,
Page 5 and 6: Ultrafiltrationpositive pressureneg
Page 7 and 8: Diffusion vs. ConvectionDiffusion i
Page 9 and 10: AdsorptionMolecular adherence to th
Page 11 and 12: Modes of Renal Replacement TherapyP
Page 13 and 14: Replacement FluidsAccessM100PR I S
Page 15: Blood Flow Rate Requirementsin Post
Page 18 and 19: Clearance (mL/min)Solute Equilibrat
Page 20 and 21: Effluent-Based Clearance: Post-Dilu
Page 22 and 23: Effluent-Based Clearance: Pre-Dilut
Page 24 and 25: Effluent-Based Clearance: CVVHDQ E
Page 26 and 27: Effluent-Based Clearance: CVVHDFQ R
Page 28 and 29: CRRT Dose: Urea-Based Versus Efflue
Page 30 and 31: Dose vs Outcome in Post-Dilution CV
Page 32 and 33: Treatment Parameters in Comparative
Page 34 and 35: ATN Trial1164 patients31 sites (24
Page 36 and 37: ATN Study: Characteristics of IHD G
Page 38 and 39: ATN Study: Primary OutcomeVA/NIH Tr
Page 40 and 41: R.E.N.A.L. Trial1508 patients35 sit
Page 42 and 43: Mortality Outcomes in RENAL
Page 44 and 45: Comparison of RENAL with ATNVariabl

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