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<strong>CRRT</strong> Dose: Urea-Based Versus Effluent-Based*Post-CVVH Pre-CVVH CVVHD CVVHDFUrea Dose** 38.8 29.5 38.8 34.1Effluent Dose** 38.8 38.8 38.8 38.8*: Q B = 180 mL/min; Q E = 3.1 L/hr; Patient weight loss = 100 mL/hr**: Results expressed as mL/kg/hr, based on 80 kg body weight
Patient Groups in CVVH Dose StudyRonco et al., Lancet 2000492 patients considered425 patients randomized67 excluded146 assignedultrafiltrationat 20 mL h -1 kg -1139 assignedultrafiltrationat 35 mL h -1 kg -1140 assignedultrafiltrationat 45 mL h -1 kg -1146 Patientscompleted studywith ultrafiltration of>85% of prescribed139 Patientscompleted studywith ultrafiltration of>85% of prescribed140 Patientscompleted studywith ultrafiltration of>85% of prescribed
Page 1 and 2: CRRT Dose WorkshopWilliam R. Clark,
Page 3 and 4: Dose of Treatment• The concept of
Page 5 and 6: Ultrafiltrationpositive pressureneg
Page 7 and 8: Diffusion vs. ConvectionDiffusion i
Page 9 and 10: AdsorptionMolecular adherence to th
Page 11 and 12: Modes of Renal Replacement TherapyP
Page 13 and 14: Replacement FluidsAccessM100PR I S
Page 15: Blood Flow Rate Requirementsin Post
Page 18 and 19: Clearance (mL/min)Solute Equilibrat
Page 20 and 21: Effluent-Based Clearance: Post-Dilu
Page 22 and 23: Effluent-Based Clearance: Pre-Dilut
Page 24 and 25: Effluent-Based Clearance: CVVHDQ E
Page 26 and 27: Effluent-Based Clearance: CVVHDFQ R
Page 30 and 31: Dose vs Outcome in Post-Dilution CV
Page 32 and 33: Treatment Parameters in Comparative
Page 34 and 35: ATN Trial1164 patients31 sites (24
Page 36 and 37: ATN Study: Characteristics of IHD G
Page 38 and 39: ATN Study: Primary OutcomeVA/NIH Tr
Page 40 and 41: R.E.N.A.L. Trial1508 patients35 sit
Page 42 and 43: Mortality Outcomes in RENAL
Page 44 and 45: Comparison of RENAL with ATNVariabl

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