Q - CRRT Online

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ATN Study: Primary OutcomeVA/NIH Trial Group, NEJM 2008
Comparison of Major <strong>CRRT</strong> Dose TrialsRonco Saudan Tolwani ATNNumber of patients 425 206 200 1124Multi-center RCT No No No YesCKD (%) NA 33 42 ExclusionPredominant AKI cause Surgical Sepsis Sepsis IschemiaAPACHE II ~23 25 26 ~29Initiation BUN (mg/dL) 53 83 75 65Modality post CVVH pre CVVHDF pre CVVHDF pre CVVHDF% Convective 100 ~60 43-44 50Prescribed dose (mL/kg/h) 20/35/45 25/42 20/35 20/35Effective dose (mL/kg/h) 20/35/45 ~20/37 ~17/29 ~17/27ICU wait (days) NA NA 8 6.9
Page 1 and 2: CRRT Dose WorkshopWilliam R. Clark,
Page 3 and 4: Dose of Treatment• The concept of
Page 5 and 6: Ultrafiltrationpositive pressureneg
Page 7 and 8: Diffusion vs. ConvectionDiffusion i
Page 9 and 10: AdsorptionMolecular adherence to th
Page 11 and 12: Modes of Renal Replacement TherapyP
Page 13 and 14: Replacement FluidsAccessM100PR I S
Page 15: Blood Flow Rate Requirementsin Post
Page 18 and 19: Clearance (mL/min)Solute Equilibrat
Page 20 and 21: Effluent-Based Clearance: Post-Dilu
Page 22 and 23: Effluent-Based Clearance: Pre-Dilut
Page 24 and 25: Effluent-Based Clearance: CVVHDQ E
Page 26 and 27: Effluent-Based Clearance: CVVHDFQ R
Page 28 and 29: CRRT Dose: Urea-Based Versus Efflue
Page 30 and 31: Dose vs Outcome in Post-Dilution CV
Page 32 and 33: Treatment Parameters in Comparative
Page 34 and 35: ATN Trial1164 patients31 sites (24
Page 36 and 37: ATN Study: Characteristics of IHD G
Page 40 and 41: R.E.N.A.L. Trial1508 patients35 sit
Page 42 and 43: Mortality Outcomes in RENAL
Page 44 and 45: Comparison of RENAL with ATNVariabl

Q - CRRT Online

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