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ATN Trial1164 patients31 sites (24 VA, 7 other)3 yearsRandomizationStablehemodynamics(SOFA 0-2)Unstablehemodynamics(SOFA 3-4)IntensiveManagement Strategy(582 patients)• IHD 6x/week @ Kt/V of~1.2/session• CVVHDF @35 mL/kg/hr, or• SLED/EDD 6x/weekConventionalManagement Strategy(582 patients)• IHD 3x/week @ Kt/V of~1.2/session• CVVHDF @20 mL/kg/hr, or• SLED/EDD 3x/week
Modality Prescription in ATN StudyVA/NIH Trial Group, NEJM 2008Hemodynamic Status Modality Number of PercentageTreatments of TreatmentsStable* IHD 5077 100%Unstable** <strong>CRRT</strong> 5967 95.2%SLED 299 4.8%*: SOFA score: 0, 1, or 2**: SOFA score: 3 or 4
Page 1 and 2: CRRT Dose WorkshopWilliam R. Clark,
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Page 15: Blood Flow Rate Requirementsin Post
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Page 22 and 23: Effluent-Based Clearance: Pre-Dilut
Page 24 and 25: Effluent-Based Clearance: CVVHDQ E
Page 26 and 27: Effluent-Based Clearance: CVVHDFQ R
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Page 32 and 33: Treatment Parameters in Comparative
Page 36 and 37: ATN Study: Characteristics of IHD G
Page 38 and 39: ATN Study: Primary OutcomeVA/NIH Tr
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