Exploring the amyloid state of proteins by micro

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Eosinophile (type of white blood cell) granulesCharacterized by George Palade et al. (1965) by EMUnit cell dimensions tentatively determined byAlice Soragni, Jacques Colletier,Manfred Brunner, Christian Riekel
Cell Types Containing Intracellular Crystalline InclusionsSpecies Cell type Description of crystals Protein ReferenceDrosophila Crystal cells Intracellular inclusions [lamellar] Prophenol oxidase (Shrestha & Gateff 1982);T. M. Rizki & R. M. Rizki 1980)HumanRatGuinea pigMouseEosinophil leukocytesMembrane-bound granules [0.3-1.2 um]Granule cores [lamellar]? (Miller et al. 1966)Human B cell lymphomas ER-bound crystal rods [lamellar] Ig (Peters et al. 1984)Human Abnormal mitochondria inmuscle myopathiesCrystal rods in outer mitochondrialmembrane compartmentMitochondrial creatine kinase (Stadhouders et al. 1994)Human Kidney mitochondria Helical crystals in outer mitochondrial ? Jasmin 1978compartment; linear and flexuous crystalsin matrixHumanDogMonkeyLiver mitochondria Intramitochondrial [lamellar] ? Wills 1965Human Ad5-infected KB cells Intranuclear adenovirus-induced inclusions heteromeric capsid protein (Franqueville et al. 2008);formed of penton base and (Carstens et al. 1975)fiber subunitsFrog Oocyte mitochondria Intramatrix & intracristae inclusions[lamellar]? Spornitz 1972Armadillo Epididymus Single membrane-bound cytoplasmiccrystalline rods [lamellar]? (Edmonds et al. 1973)Earthworm Spermatazoa Intranuclear inclusions [lamellar] ? (Anderson et al. 1968)Tomato Young leaf mesophyll Intracellular inclusions [Cubic] ? Singh 1976Helicobacter pyloriCausative agent of gastricdiseasesCytoplasmic paracrystalline inclusions Pfr, bacterial ferritin (Frazier et al. 1993)Photorhabdus luminescens Entomopathogenic bacteria Intracellular inclusions cipAcipB(Bintrim et al. 1998)Bacillus thuringiensis Insecticidal bacteria parasporal crystals Cry (Hofte et al. 1989)Paenibacillus popilliae Insecticidal bacteria parasporal crystals ? Weiner 1978Brevibacillus laterosporus Mosquitocidal bacteria parasporal crystals ? (Smirnova et al. 1996); (Orlovaet al. 1998)
Page 1 and 2: The Amyloid State of Proteinsand Mi
Page 3 and 4: Amyloid• Unbranched, elongated pr
Page 5 and 6: My Scientific Dilemma in 2001Import
Page 7 and 8: 10-100 mM < 24 hrGNNQQNY microcryst
Page 9 and 10: Packing of GNNQQNY peptides in micr
Page 11 and 12: Microfocus is required to reducebac
Page 13 and 14: GNNQQNY, a dry steric zipperFibers
Page 15 and 16: As of April 2011, ~90 X-raycrystal
Page 17 and 18: D-TLKIVW prevents fibril formation
Page 19 and 20: GGVVIA +JugloneMeytal LandauGGVVIA
Page 21 and 22: Structure of KLVFFA with Orange GKL
Page 23 and 24: Amyloid-like crystalsof KLIMY from
Page 25 and 26: Nano-crystals oflonger (11-residue)
Page 27 and 28: 10 micron Mictigen micromesh in cry
Page 29: Drosophila crystal cellon 10 µm me
Page 33 and 34: The Amyloid State of ProteinsUCLA:

Exploring the amyloid state of proteins by micro

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