Exploring the amyloid state of proteins by micro
Exploring the amyloid state of proteins by micro
Exploring the amyloid state of proteins by micro
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Short segments <strong>of</strong> fiber-forming <strong>proteins</strong>form both <strong>amyloid</strong> fibers and <strong>micro</strong>crystalsGNNQQNYsinglefibril~80ÅBalbirnie et al. PNAS 2001singlefibril~80ÅNNQQNNQQIn both <strong>micro</strong>crystalsand fibrils,β-strands are normalto <strong>the</strong> long axis.NNQQNYGNNQQNY~280Å0.5mmGNNQQNY fibrils exhibit allproperties <strong>of</strong> <strong>amyloid</strong> fibrils:dye binding, cooperativeaggregation kinetics, stability,cross-β diffraction1μm1μmFibers seem to growfrom tips <strong>of</strong> crystals
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