Exploring the amyloid state of proteins by micro

More documents

Recommendations

Info

Amyloid Fibril-Related ConditionsAmyloid (24) Prion (transmissible) Amyloid-likeAlzheimer’s Aβ [Psi+] Sup35Alzheimer’s Tau [Ure2] Ure3 Parkinson’s α-synucleinDiabetes IIAmylinaka IAPPLouGehrig’s(ALS)SuperoxideDismutaseTDP-43InjectionInsulinCJD, GSSPrPHIV SexualSEVIamyloidosisKurutransmissionDialysisamyloidosisβ2-microglobulinBSE, vCJD(mad cow)PrP Cancer p53SenileTrans-amyloidosisthyritin
My Scientific Dilemma in 2001Important biological problem—structure of amyloid5.4 M Alzheimer’s patients in US in 2010~19 M patients expected by 2050Economic burden:In 2010 ~$ 183B in US heath care costs~11 M people provide unpaid care of AD patientsEssentially no structural informationStructure-based design impossibleAmyloid crystals discovered but 30,000 times smallerthan crystals we had previously worked with
Page 1 and 2: The Amyloid State of Proteinsand Mi
Page 3: Amyloid• Unbranched, elongated pr
Page 7 and 8: 10-100 mM < 24 hrGNNQQNY microcryst
Page 9 and 10: Packing of GNNQQNY peptides in micr
Page 11 and 12: Microfocus is required to reducebac
Page 13 and 14: GNNQQNY, a dry steric zipperFibers
Page 15 and 16: As of April 2011, ~90 X-raycrystal
Page 17 and 18: D-TLKIVW prevents fibril formation
Page 19 and 20: GGVVIA +JugloneMeytal LandauGGVVIA
Page 21 and 22: Structure of KLVFFA with Orange GKL
Page 23 and 24: Amyloid-like crystalsof KLIMY from
Page 25 and 26: Nano-crystals oflonger (11-residue)
Page 27 and 28: 10 micron Mictigen micromesh in cry
Page 29 and 30: Drosophila crystal cellon 10 µm me
Page 31 and 32: Cell Types Containing Intracellular
Page 33 and 34: The Amyloid State of ProteinsUCLA:

Exploring the amyloid state of proteins by micro

Create successful ePaper yourself

Delete template?

Save as template?