Biomarkers of High Grade Dysplasia in Barrett's Esophagus

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Dysplasia in Barrett’s Esophagus•Negative for dysplasia•Positive for dysplasiaLow grade dysplasiaHigh grade dysplasia•Indefinite for dysplasia
Grading Dysplasia in BEFeature Negative IND LGD HGDSurface + + - -maturationArchitecture Normal Normal or mild Mild alteration Marked alterationalterationCytology Normal or Mild alterations or Mild alterations (D) Marked alteration;reactive focal marked with or marked (F); loss of polarityinflammation maintained polarity(Montgomery et al Human Pathology 2001)
Page 1: Biomarkers of High GradeDysplasia i
Page 7: Barrett’s Esophagus• 5-15% of a
Page 12 and 13: Barrett’s Esophagus SequelaeUlcer
Page 14 and 15: Histopathologic Dx of DysplasiaDysp
Page 18: LGD
Page 21 and 22: Dysplasia in BEPitfalls• Sampling
Page 23 and 24: Ancillary Techniques in theScreenin
Page 25 and 26: Advantages over other microarray st
Page 27 and 28: Specimen Evaluation40 cases (1-6 bl
Page 29 and 30: Biopsy of Normal BE
Page 31 and 32: Use of Aperio ScanScope for Remote
Page 33 and 34: BioinformaticsExpression signals no
Page 35: Dysregulated Genes in HGD by Functi
Page 38 and 39: CAMK2N1MUC5ACHSD17BPGDHAMEP1AALDOBA
Page 40 and 41: Topoisomerase II alpha
Page 42 and 43: S100-A9
Page 44 and 45: Immunohistochemical stains for topo
Page 46 and 47: Thanks to…….Patricia A. Meitner

Biomarkers of High Grade Dysplasia in Barrett's Esophagus

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