Biomarkers of High Grade Dysplasia in Barrett's Esophagus

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Laser Capture MicrodissectionBarrett’s EpitheliumHigh Grade DysplasiaABABCDCDEsophageal epithelium stained with Histogene staining solution (A), marked for capture (B),after capture (C) and captured cells after dissection (D)
BioinformaticsExpression signals normalized using the Standardization andNormalization of Microarray Data web-based softwareConcordant absent expression signals were removed from analysisStatistical comparison of HGD to ND was done using the Wilcoxonmatched-pairs signal ranks test (>2.5 fold cutoff, p
Page 1: Biomarkers of High GradeDysplasia i
Page 7: Barrett’s Esophagus• 5-15% of a
Page 12 and 13: Barrett’s Esophagus SequelaeUlcer
Page 14 and 15: Histopathologic Dx of DysplasiaDysp
Page 16 and 17: Dysplasia in Barrett’s Esophagus
Page 18: LGD
Page 21 and 22: Dysplasia in BEPitfalls• Sampling
Page 23 and 24: Ancillary Techniques in theScreenin
Page 25 and 26: Advantages over other microarray st
Page 27 and 28: Specimen Evaluation40 cases (1-6 bl
Page 29 and 30: Biopsy of Normal BE
Page 31: Use of Aperio ScanScope for Remote
Page 35: Dysregulated Genes in HGD by Functi
Page 38 and 39: CAMK2N1MUC5ACHSD17BPGDHAMEP1AALDOBA
Page 40 and 41: Topoisomerase II alpha
Page 42 and 43: S100-A9
Page 44 and 45: Immunohistochemical stains for topo
Page 46 and 47: Thanks to…….Patricia A. Meitner

Biomarkers of High Grade Dysplasia in Barrett's Esophagus

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