Biomarkers of High Grade Dysplasia in Barrett's Esophagus
Biomarkers of High Grade Dysplasia in Barrett's Esophagus
Biomarkers of High Grade Dysplasia in Barrett's Esophagus
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Immunohistochemical sta<strong>in</strong>s for topoisomerase IIa (Topo), lipocal<strong>in</strong>-2 (Lipo),S100A9 (S-100), and TFF1. ADCA, adenocarc<strong>in</strong>omaTopoNumber <strong>of</strong> cases15105012(100%)p < 0.01 for:NDBE vs AllLGD vs HGD075 6(58%) 5 4(45%)(55%)(42%) (33%)0 0 0(8%)1NDBE LGD HGD ADCA7(58%)Number <strong>of</strong> casesLipo12108642011(92%)p < 0.02 for:NDBE vs All21(18%)(8%)05(46%) 4(36%)5(42%)5(42%)2(16%)7(58%)5(42%)NDBE LGD HGD ADCA0Number <strong>of</strong> casesS-10012108642012(100%)0 0p < 0.03 for:NDBE vs AllHGD vs ADCA7(64%)4(36%)07(58%)5(42%)01(8%)NDBE LGD HGD ADCA6(50%) 5(42%)Number <strong>of</strong> casesTFF1IHC Score = +1 IHC Score = +2 IHC Score = +31210864200 012(100%)4(36%)p < 0.03 for:NDBE vs AllLGD vs HGD9(82%)1(9%)6(55%)1 1(9%) (9%)11(92%)01(8%)NDBE LGD HGD ADCA
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