Biomarkers of High Grade Dysplasia in Barrett's Esophagus

More documents

Recommendations

Info

Barrett’s Related DysplasiaInterobserver AgreementCategory%AgreementHGD+IMC vs others 85-87%Negative vs others 71-72%Negative+Ind vs others 75-77%Neg vs ind/LG vs HGD/IMC 58-61%Reid BJ et al Human Pathology 1988
Ancillary Techniques in theScreening and DX of BEFlow cytometry Aneuploidy more common in HGD and maybe a marker for progressionMolecular P53 (late)Cyclin D1 expression (early)Telomerase (early and non-dysplastic)p16 hypermethylation or mutation (early)Brush cytology and balloon cytology“Light” biopsy (fluorescence, optical coherence tomography)
Page 1: Biomarkers of High GradeDysplasia i
Page 7: Barrett’s Esophagus• 5-15% of a
Page 12 and 13: Barrett’s Esophagus SequelaeUlcer
Page 14 and 15: Histopathologic Dx of DysplasiaDysp
Page 16 and 17: Dysplasia in Barrett’s Esophagus
Page 18: LGD
Page 21: Dysplasia in BEPitfalls• Sampling
Page 25 and 26: Advantages over other microarray st
Page 27 and 28: Specimen Evaluation40 cases (1-6 bl
Page 29 and 30: Biopsy of Normal BE
Page 31 and 32: Use of Aperio ScanScope for Remote
Page 33 and 34: BioinformaticsExpression signals no
Page 35: Dysregulated Genes in HGD by Functi
Page 38 and 39: CAMK2N1MUC5ACHSD17BPGDHAMEP1AALDOBA
Page 40 and 41: Topoisomerase II alpha
Page 42 and 43: S100-A9
Page 44 and 45: Immunohistochemical stains for topo
Page 46 and 47: Thanks to…….Patricia A. Meitner

Biomarkers of High Grade Dysplasia in Barrett's Esophagus

Create successful ePaper yourself

Delete template?

Save as template?