Diagnostic Assessment & Treatment of Adult ADHD
Diagnostic Assessment & Treatment of Adult ADHD
Diagnostic Assessment & Treatment of Adult ADHD
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Neurobiology <strong>of</strong> <strong>ADHD</strong>• Highly heritable (80% <strong>of</strong> variance explained bygenetic factors)• Neurobiological disorder:– brain 5% smaller and less active: dACC, globuspallidus, caudatus, dLPFC, cerebellum– 8 kandidate genes, esp. dopaminergic (DRD2,4,5,DAT1)– Inhibition deficit based on dopamine deficiency– Methylphenidate: dopamine agonist; acts as inhibitor<strong>of</strong> associations, moodswings, restlessness andimpulsivityThapar 1999; Faraone 2005; Castellanos 2002; Bush 2006Kessler 2006; Kooij 2005
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