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Infectiologic differential diagnosis of chronic Lyme disease and so ...

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In the <strong>differential</strong> <strong>diagnosis</strong> <strong>of</strong> <strong>Lyme</strong> <strong>disease</strong> <strong>and</strong> with regard to coinfection, the<br />

importance <strong>of</strong> yersiniosis is primarily based on the <strong>disease</strong> manifestation <strong>of</strong> a <strong>so</strong>-<br />

called reactive arthritis. As in Chlamydia infections <strong>and</strong> probably al<strong>so</strong> in the<br />

bartonellosis, the arthritis is very probably the consequence <strong>of</strong> a <strong>chronic</strong> persistent<br />

infection [163, 164]. Since the <strong>so</strong>-called reactive arthritis in yersiniosis occasionally<br />

al<strong>so</strong> occurs in the scope <strong>of</strong> Reiter's triad, i.e. in connection with urethritis <strong>and</strong> uveitis,<br />

the autoimmune processes are to be discussed with the pathophysiology. The<br />

thyroiditis which frequently occurs in yersiniosis <strong>and</strong> which is very probably<br />

expression <strong>of</strong> an autoimmune phenomenon as in LD is indicative <strong>of</strong> such an<br />

as<strong>so</strong>ciation.<br />

The anamnestic research subsequent to the early phase <strong>of</strong> yersiniosis makes an<br />

important contribution to the recognition <strong>of</strong> <strong>chronic</strong> yersiniosis. The early phase <strong>of</strong><br />

yersiniosis is essentially characterized by two <strong>disease</strong> manifestations:<br />

- Gradually beginning gastroenteritis<br />

- Pharyngitis<br />

The infection data <strong>and</strong> symptomatology <strong>of</strong> yersiniosis are compiled in Table 16.<br />

Table 16<br />

Yersiniosis (Y. enterocolitica)<br />

Infection data, symptomatology<br />

Pathogen:<br />

- Yersinia enterocolitica<br />

Transmission:<br />

- Fecal-oral<br />

Reservoir:<br />

- Various vertebrates<br />

Early phase:<br />

- Gradual development <strong>of</strong> gastroenteritis<br />

(for about one week)<br />

- Gastroenteritis<br />

26

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