Infectiologic differential diagnosis of chronic Lyme disease and so ...

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Probable: IFA IgG 1:1024 and one of the following criteria: � Valvular heart disease � Known aneurysm � Prosthetic material in cardiovascular system � Detection of infection on heart valves, vessels and vascular prostheses � Suspicion of osteomyelitis � Suspicion of hepatitis � Pregnancy � Symptoms of a chronic infection (fever, weight loss, night sweats, hepatomegaly, elevated ESR, elevated CRP) � Granulomatous tissue inflammation (histologically verified) � A compromised immune system Possible: IFA IgG 1:1024 Frequent follow-up examinations are required during the disease course. On suspicion of chronic Q fever: Echocardiography PET CT scan Antibiotic treatment of chronic Q fever: Doxycycline Hydroxychloroquine Macrolides (azithromycin, clarithromycin, telithromycin) � Fluoroquinolone � Trimethoprim and sulfamethoxazole [345, 347-348] In cases of chronic Q fever, treatment with doxycycline + hydroxychloroquine as a long-term treatment, i.e. for 18 months, is recommended [350]. Human parvovirus B19 infection Pathogen: human parvovirus B19 48
Transmission: respiratory tract (droplet infection) Transmission during pregnancy Blood transfusion Reservoir: human beings The disease can exhibit a chronic course, i.e. over months and years [171]. Whether parvovirus B19 causes chronic myocarditis and cardiomyopathy is a matter of dispute [172-175]. The chronic course is verified by means of pathogen detection in articular effusion, myocardium, bone marrow, and blood [169-175]. With regard to Lyme disease, the following differential diagnostic disease manifestations are relevant: - Persistent or recurrent arthropathy - Myocarditis - Cardiomyopathy Fifth disease (erythema infectiosum) is a typical skin manifestation of a parvovirus B19 infection in children, but does not normally occur in adults. Arthralgias can last for months or years. For further information refer to the relevant medical literature. Campylobacter jejuni Campylobacter jejuni (Cj) is a small gram-negative bacterium whose pathological significance was recognized in the 1980s. Worldwide, Cj is among the most frequent pathogens causing acute diarrhea Sources of infection are game animals and domestic animals, animal products and especially poultry [299]. The pathogen can persist in a coccoid form, but also in its normal form, for months in cases of unfavorable living conditions. It penetrates into the epithelial cells of the intestine and causes their destruction, possibly by means of toxins [303, 304]. 49
Page 1 and 2: Infectiologic differential diagnosi
Page 3 and 4: 3 Anamnistically, one has to consid
Page 5 and 6: Table 2 LD coinfections (not tick-b
Page 7 and 8: Table 5 Bartonellosis’ infection
Page 9 and 10: Table 6 Main disease manifestations
Page 11 and 12: 11 Fig. 1. Erythrocytes infected wi
Page 13 and 14: 13 Bartonellae are localized in ery
Page 15 and 16: ESR und CRP elevated Hypercalcemia
Page 18 and 19: Table 9 Antibiotic treatment of bar
Page 20 and 21: antibiosis is that the antibiotic i
Page 22 and 23: The laboratory diagnostics for Chla
Page 24 and 25: The arthritis occurs in 1% of the u
Page 26 and 27: In the differential diagnosis of Ly
Page 28 and 29: Late phase: - Reactive arthritis -
Page 30 and 31: the depiction of chronic yersiniosi
Page 32 and 33: In Yersinia-PCR-positive patients,
Page 34 and 35: - Incubation period 3 weeks - Atypi
Page 36 and 37: system, of the skin and other organ
Page 38 and 39: - Ehrlichia chaffeensis [1] - Anapl
Page 40 and 41: Since seroprevalence merely express
Page 42 and 43: B. microti is the predominant patho
Page 44 and 45: epresent a major health hazard and
Page 46 and 47: The decisive diagnostic information
Page 50 and 51: The main manifestation of the Campy
Page 52 and 53: The term “reactive arthritis” i
Page 54 and 55: In the diagnosis of a “reactive a
Page 56 and 57: Table 27 Disease manifestations of
Page 58 and 59: addition, other pathogens discussed
Page 60 and 61: [8] Schouls LM, Van De Pol I, Rijpk
Page 62 and 63: [25] Hermanowska-Szpakowicz T, Skot
Page 64 and 65: [43] Bakken JS, Krueth JK, Lund T,
Page 66 and 67: [60] Fox LM, Wingerter S, Ahmed A e
Page 68 and 69: [80] Marra CM. Neurologic complicat
Page 70 and 71: [100] Pulliainen AT, Dehio C. Barto
Page 72 and 73: [118] Bass JW, Freitas BC, Freitas
Page 74 and 75: [137] Gaydos CA, Roblin PM, Hammers
Page 76 and 77: [155] Cover TL, Aber RC. Yersinia e
Page 78 and 79: multi-organ donors for the presence
Page 80 and 81: [190] Straubinger RK, Straubinger A
Page 82 and 83: [208] Bitnun A, Ford-Jones E, Blase
Page 84 and 85: patients with reactive and undiffer
Page 86 and 87: [242] Appelbaum PC, Gillespie SH, B
Page 88 and 89: pneumoniae infection associated wit
Page 90 and 91: [276] Thomas NH, Collins JE, Robb S
Page 92 and 93: [294] File TM Jr, Segreti J, Dunbar
Page 94 and 95: [310] Sorvillo FJ, Lieb LE, Waterma
Page 96 and 97: henselae Isolates Collected from Ca
Page 98 and 99:
[345] Raoult D, Levy PY, Harlé JR,
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